Megha H. Talati, Ph.D.

Research Assistant Professor

megha.talati@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Life Sciences, University of Mumbai, Mumbai, IndiaM.S., Microbiology, Maharaja Sayajirao University , Baroda, IndiaB.S., Microbiology, University of Mumbai, Mumbai, India
Office Address
T-1218 MCN
Allergy, Pulmonary and Critical Care Medicine
TN 37232-2650
Publications
Suzuki T, Carrier EJ, Talati MH, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West J. Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2018 Jan 1/1/2018; 314(1): L118-L126. PMID: 28935639, PMCID: PMC5866427, PII: ajplung.00296.2017, DOI: 10.1152/ajplung.00296.2017, ISSN: 1522-1504.

Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 May 5/17/2016; 133(20): 1936-44. PMID: 27006481, PMCID: PMC4870107, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.

Yan L, Chen X, Talati M, Nunley BW, Gladson S, Blackwell T, Cogan J, Austin E, Wheeler F, Loyd J, West J, Hamid R. Bone Marrow-derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2016 Apr 4/15/2016; 193(8): 898-909. PMID: 26651104, PMCID: PMC4849178, DOI: 10.1164/rccm.201502-0407OC, ISSN: 1535-4970.

Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Apr 4/14/2016; PMID: 27077479, DOI: 10.1164/rccm.201507-1444OC, ISSN: 1535-4970.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PMCID: PMC4838140, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.

Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED. Estrogen Metabolite 16a-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism. Circulation [print-electronic]. 2016 Jan 1/5/2016; 133(1): 82-97. PMID: 26487756, PMCID: PMC4698046, PII: CIRCULATIONAHA.115.016133, DOI: 10.1161/CIRCULATIONAHA.115.016133, ISSN: 1524-4539.

Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD. Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Pulm Circ. 2015 Dec; 5(4): 681-90. PMID: 26697175, PMCID: PMC4671742, PII: PC2013257, DOI: 10.1086/683811, ISSN: 2045-8932.

Talati M, Hemnes A. Fatty acid metabolism in pulmonary arterial hypertension: role in right ventricular dysfunction and hypertrophy. Pulm Circ. 2015 Jun; 5(2): 269-78. PMID: 26064451, PMCID: PMC4449237, PII: PC2013149, DOI: 10.1086/681227, ISSN: 2045-8932.

Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am. J. Physiol., Cell Physiol. 2014 Oct 10/15/2014; 307(8): C684-98. PMID: 25122876, PMCID: PMC4200000, PII: ajpcell.00114.2014, DOI: 10.1152/ajpcell.00114.2014, ISSN: 1522-1563.

Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J. Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 2014 Feb 2/1/2014; 189(3): 325-34. PMID: 24274756, PMCID: PMC3977729, DOI: 10.1164/rccm.201306-1086OC, ISSN: 1535-4970.

Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K. BMP pathway regulation of and by macrophages. PLoS ONE. 2014; 9(4): e94119. PMID: 24713633, PMCID: PMC3979749, PII: PONE-D-12-05427, DOI: 10.1371/journal.pone.0094119, ISSN: 1932-6203.

Talati M, Seeley E, Ihida-Stansbury K, Delisser H, McDonald H, Ye F, Zhang X, Shyr Y, Caprioli R, Meyrick B. Altered expression of nuclear and cytoplasmic histone H1 in pulmonary artery and pulmonary artery smooth muscle cells in patients with IPAH. Pulm Circ. 2012 Jul; 2(3): 340-51. PMID: 23130102, PMCID: PMC3487302, PII: PC-2-340, DOI: 10.4103/2045-8932.101645, ISSN: 2045-8940.

Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet [print-electronic]. 2012 Jun; 5(3): 336-43. PMID: 22474227, PMCID: PMC3380156, PII: CIRCGENETICS.111.961888, DOI: 10.1161/CIRCGENETICS.111.961888, ISSN: 1942-3268.

Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): L474-84. PMID: 22180660, PMCID: PMC3311512, PII: ajplung.00202.2011, DOI: 10.1152/ajplung.00202.2011, ISSN: 1522-1504.

Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul; 1(3): 389-98. PMID: 22140629, PMCID: PMC3224431, PII: PC-1-389, DOI: 10.4103/2045-8932.87308, ISSN: 2045-8940.

Lane KL, Talati M, Austin E, Hemnes AR, Johnson JA, Fessel JP, Blackwell T, Mernaugh RL, Robinson L, Fike C, Roberts LJ, West J. Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ. 2011; 1(1): 72-83. PMID: 21904662, PMCID: PMC3167174, DOI: 10.4103/2045-8932.78107, ISSN: 2045-8932.

Talati M, West J, Blackwell TR, Loyd JE, Meyrick B. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2010 Sep; 299(3): L363-73. PMID: 20562228, PMCID: PMC2951074, PII: ajplung.00295.2009, DOI: 10.1152/ajplung.00295.2009, ISSN: 1522-1504.

Talati M, Meyrick B, Peebles RS, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ, Sheller JR. Oxidant stress modulates murine allergic airway responses. Free Radic. Biol. Med [print-electronic]. 2006 Apr 4/1/2006; 40(7): 1210-9. PMID: 16545689, PII: S0891-5849(05)00710-0, DOI: 10.1016/j.freeradbiomed.2005.11.012, ISSN: 0891-5849.

Davies SS, Talati M, Wang X, Mernaugh RL, Amarnath V, Fessel J, Meyrick BO, Sheller J, Roberts LJ. Localization of isoketal adducts in vivo using a single-chain antibody. Free Radic. Biol. Med. 2004 May 5/1/2004; 36(9): 1163-74. PMID: 15082070, PII: S0891584904001315, DOI: 10.1016/j.freeradbiomed.2004.02.014, ISSN: 0891-5849.

Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD, Hashimoto Y, Christman JW, Kang KH, Jarzecka K, Furlong J, Mitchell DB, Talati M, Graham BS, Sheller JR. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 2002 Apr 4/15/2002; 165(8): 1154-60. PMID: 11956061, DOI: 10.1164/ajrccm.165.8.2106025, ISSN: 1073-449X.