Jonathan H. Sheehan, Ph.D.

Research Associate Professor

jonathan.sheehan@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Biochemistry
Education
Ph.D., Biochemistry, Vanderbilt University, Nashville, TennesseeA.B., Harvard University, Cambridge, Massachusetts
Office Address
Vanderbilt Univ. Ctr. for Struct. Biol.
465 21st Avenue S.
Nashville, TN 37232-8755
Research Keywords
Computational structural biology, protein and DNA modeling and simulation.
Publications
Hanker AB, Brewer MR, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, Lovly CM, Meiler J, Arteaga CL. An Acquired HER2(T798I) Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Cancer Discov [print-electronic]. 2017 Jun; 7(6): 575-85. PMID: 28274957, PMCID: PMC5457707, PII: 2159-8290.CD-16-1431, DOI: 10.1158/2159-8290.CD-16-1431, ISSN: 2159-8290.

Bender BJ, Cisneros A, Duran AM, Finn JA, Fu D, Lokits AD, Mueller BK, Sangha AK, Sauer MF, Sevy AM, Sliwoski G, Sheehan JH, DiMaio F, Meiler J, Moretti R. Protocols for Molecular Modeling with Rosetta3 and RosettaScripts. Biochemistry [print-electronic]. 2016 Aug 8/30/2016; 55(34): 4748-63. PMID: 27490953, PMCID: PMC5007558, DOI: 10.1021/acs.biochem.6b00444, ISSN: 1520-4995.

Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL. The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy. Expert Rev Clin Immunol [print-electronic]. 2016 Jul; 12(7): 763-73. PMID: 26864273, PMCID: PMC5070917, DOI: 10.1586/1744666X.2016.1152888, ISSN: 1744-8409.

Konduri K, Gallant JN, Chae YK, Giles FJ, Gitlitz BJ, Gowen K, Ichihara E, Owonikoko TK, Peddareddigari V, Ramalingam SS, Reddy SK, Eaby-Sandy B, Vavalà T, Whiteley A, Chen H, Yan Y, Sheehan JH, Meiler J, Morosini D, Ross JS, Stephens PJ, Miller VA, Ali SM, Lovly CM. EGFR Fusions as Novel Therapeutic Targets in Lung Cancer. Cancer Discov [print-electronic]. 2016 Jun; 6(6): 601-11. PMID: 27102076, PMCID: PMC4893907, PII: 2159-8290.CD-16-0075, DOI: 10.1158/2159-8290.CD-16-0075, ISSN: 2159-8290.

Gallant JN, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, Red Brewer M, York SJ, Kris MG, Pietenpol JA, Ladanyi M, Miller VA, Ali SM, Meiler J, Lovly CM. EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib. Cancer Discov [print-electronic]. 2015 Nov; 5(11): 1155-63. PMID: 26286086, PMCID: PMC4631701, PII: 2159-8290.CD-15-0654, DOI: 10.1158/2159-8290.CD-15-0654, ISSN: 2159-8290.

Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS. Computational and functional analyses of a small-molecule binding site in ROMK. Biophys. J. 2015 Mar 3/10/2015; 108(5): 1094-103. PMID: 25762321, PMCID: PMC4375722, PII: S0006-3495(15)00116-2, DOI: 10.1016/j.bpj.2015.01.022, ISSN: 1542-0086.

Donahue JP, Levinson RT, Sheehan JH, Sutton L, Taylor HE, Meiler J, D'Aquila RT, Song C. Genetic analysis of the localization of APOBEC3F to human immunodeficiency virus type 1 virion cores. J. Virol [print-electronic]. 2015 Feb; 89(4): 2415-24. PMID: 25505075, PMCID: PMC4338907, PII: JVI.01981-14, DOI: 10.1128/JVI.01981-14, ISSN: 1098-5514.

Akram ON, DeGraff DJ, Sheehan JH, Tilley WD, Matusik RJ, Ahn JM, Raj GV. Tailoring peptidomimetics for targeting protein-protein interactions. Mol. Cancer Res [print-electronic]. 2014 Jul; 12(7): 967-78. PMID: 24642350, PII: 1541-7786.MCR-13-0611, DOI: 10.1158/1541-7786.MCR-13-0611, ISSN: 1557-3125.

Grabowska MM, Elliott AD, DeGraff DJ, Anderson PD, Anumanthan G, Yamashita H, Sun Q, Friedman DB, Hachey DL, Yu X, Sheehan JH, Ahn JM, Raj GV, Piston DW, Gronostajski RM, Matusik RJ. NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression. Mol. Endocrinol [print-electronic]. 2014 Jun; 28(6): 949-64. PMID: 24801505, PMCID: PMC4042066, DOI: 10.1210/me.2013-1213, ISSN: 1944-9917.

Egli M, Pattanayek R, Sheehan JH, Xu Y, Mori T, Smith JA, Johnson CH. Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock. Biochemistry [print-electronic]. 2013 Feb 2/19/2013; 52(7): 1208-20. PMID: 23351065, PMCID: PMC3587310, DOI: 10.1021/bi301691a, ISSN: 1520-4995.

Combs SA, Deluca SL, Deluca SH, Lemmon GH, Nannemann DP, Nguyen ED, Willis JR, Sheehan JH, Meiler J. Small-molecule ligand docking into comparative models with Rosetta. Nat Protoc [print-electronic]. 2013; 8(7): 1277-98. PMID: 23744289, PII: nprot.2013.074, DOI: 10.1038/nprot.2013.074, ISSN: 1750-2799.

Yang R, Shi J, Byeon IJ, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C. Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects. Retrovirology. 2012; 9: 30. PMID: 22515365, PMCID: PMC3351742, PII: 1742-4690-9-30, DOI: 10.1186/1742-4690-9-30, ISSN: 1742-4690.

Olmsted IR, Xiao Y, Cho M, Csordas AT, Sheehan JH, Meiler J, Soh HT, Bornhop DJ. Measurement of aptamer­-protein interactions with back-­scattering interferometry. Analytical Chemistry. 2011; 23((83)): 8867­70.

Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. J. Biol. Chem [print-electronic]. 2010 Oct 10/8/2010; 285(41): 31348-61. PMID: 20639197, PMCID: PMC2951209, PII: M110.151449, DOI: 10.1074/jbc.M110.151449, ISSN: 1083-351X.

Dave S, Sheehan JH, Meiler J, Strange K. Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker. Channels (Austin) [print-electronic]. 2010 Jul; 4(4): 289-301. PMID: 20581474, PMCID: PMC3230521, PII: 12445, ISSN: 1933-6969.

Kaufmann KW, Lemmon GH, Deluca SL, Sheehan JH, Meiler J. Practically useful: what the Rosetta protein modeling suite can do for you. Biochemistry. 2010 Apr 4/13/2010; 49(14): 2987-98. PMID: 20235548, PMCID: PMC2850155, DOI: 10.1021/bi902153g, ISSN: 1520-4995.

Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS. The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating. Channels (Austin) [print-electronic]. 2009 Jan; 3(1): 57-68. PMID: 19221509, PII: 7817, ISSN: 1933-6969.

Sheehan JH, Bunick CG, Hu H, Fagan PA, Meyn SM, Chazin WJ. Structure of the N-terminal calcium sensor domain of centrin reveals the biochemical basis for domain-specific function. J. Biol. Chem [print-electronic]. 2006 Feb 2/3/2006; 281(5): 2876-81. PMID: 16317001, PII: M509886200, DOI: 10.1074/jbc.M509886200, ISSN: 0021-9258.

Hu H, Sheehan JH, Chazin WJ. The mode of action of centrin. Binding of Ca2+ and a peptide fragment of Kar1p to the C-terminal domain. J. Biol. Chem [print-electronic]. 2004 Dec 12/3/2004; 279(49): 50895-903. PMID: 15452116, PII: M404233200, DOI: 10.1074/jbc.M404233200, ISSN: 0021-9258.

Bunick CG, Nelson MR, Mangahas S, Hunter MJ, Sheehan JH, Mizoue LS, Bunick GJ, Chazin WJ. Designing sequence to control protein function in an EF-hand protein. J. Am. Chem. Soc. 2004 May 5/19/2004; 126(19): 5990-8. PMID: 15137763, DOI: 10.1021/ja0397456, ISSN: 0002-7863.