Christopher V. Wright, D.Phil.


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Faculty Appointments
Professor of Cell and Developmental Biology Louise B. McGavock Chair
D.Phil., Biochemistry, University of Oxford, Oxford, United KingdomB.Sc., Biological Sciences, University of Warwick, Coventry, United Kingdom
Office Address
465 21st Avenue South
Nashville, TN 37232-8240
Research Description
Vertebrate embryos form from initially symmetric fertilized eggs as a result of progressively more complex interactions between differently programmed groups of daughter cells that arise from the cleavage of the zygote. We are studying secreted intercellular signaling molecules or transcription factors that dictate cell fates in different parts of the embryo. These include the TGF -superfamily members nodal and BMP4 (and their transmembrane kinase receptors), and homeodomain-containing transcription factors, which are expressed according to the type of extracellular signals received by a cell. Our main model systems are the frog and mouse. Frog embryos can be microinjected with plasmids, mRNA, proteins and antibodies, and the large number of embryos available allows biochemical studies. In contrast, the mouse allows genetic analysis of function. We can transgenically misexpress proteins, or genes can be inactivated or mutated by gene recombination in ES cells. The latter can be done globally, or tissue-specifically, by inactivation techniques that can be targeted to chosen tissues and switched on/off as required.

Proof of the power of these strategies comes from our finding that inactivating the pdx-1 homeobox gene completely prevents the formation of the pancreas; similar defects have been found in newborn humans with pdx-1 mutations.

Furthermore, PDX-1 is probably an essential transcriptional regulator of the insulin gene, and/or other genes involved in cell function in the Islets of Langerhans of the adult pancreas. We are determining the cis-elements activating pdx-1 in the embryonic pancreas and adult endocrine cells, studying endocrine/exocrine lineage pathways, and determining the precise role of pdx-1 and other transcriptional regulators such as the bHLH factor Ptf1a in pancreas formation, function and insulin expression. We are specifically interested in identifying pancreatic stem cells and finding ways to convert embryonic or adult stem cells (which may come from the bone marrow, nervous system, or from within the pancreas itself) into pancreatic tissue, ultimately for transplantation therapy of diabetes. We have recently found evidence that the expression of Ptf1a dictates an organ choice of endodermal stem cells between duodenal and pancreatic fates. These studies involved nactivating Ptf1a in mouse, together with lineage tracing techniques for following cells after inactivation.

Different vertebrates have variable numbers of nodal-related genes, which encode intercellular signaling molecules that induce profound alterations in cell fate or behaviours such as migration. A particularly exciting discovery made a few years ago was that a frog nodal-related gene, Xnr-1, is expressed only on the embryo's left side, where it acts to specify a "left-right" asymmetry involved in the formation of the stereotypical and required internal asymmetric anatomy of the heart, vascular system, and viscera. We are mapping the cis-acting sequences controlling Xnr-1 expression to characterize the factors activating its expression in these fascinating patterns, and investigating the extracellular regulation of this cell-cell signaling molecule. In addition, our finding that the classical zebrafish mutant, cyclops, corresponds to a lesion in a nodal-related gene has introduced new concepts regarding the timing and players involved in establishing precursors of the floor plate, an organizing tissue located ventrally in the neural tube that is required for normal CNS patterning.

Our long-term goal is to provide insight into the molecular mechanisms responsible for the coordinated development of complex organ systems, with deep relevance to human congenital birth defects.
Research Keywords
We are studying secreted intercellular signaling molecules or transcription factors that dictate cell fates in different parts of the embryo.
Blum M, Schweickert A, Vick P, Wright CV, Danilchik MV. Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?. Dev. Biol [print-electronic]. 2014 Sep 9/1/2014; 393(1): 109-23. PMID: 24972089, PMCID: PMC4481729, PII: S0012-1606(14)00310-8, DOI: 10.1016/j.ydbio.2014.06.014, ISSN: 1095-564X.

Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H. Partial duct ligation: ß-cell proliferation and beyond. Diabetes. 2014 Aug; 63(8): 2567-77. PMID: 25060885, PII: 63/8/2567, DOI: 10.2337/db13-0831, ISSN: 1939-327X.

Halpern ME, Hobert O, Wright CV. Left-right asymmetry: advances and enigmas. Genesis. 2014 Jun; 52(6): 451-4. PMID: 24943067, DOI: 10.1002/dvg.22791, ISSN: 1526-968X.

Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CV, Brissova M, Powers AC. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development [print-electronic]. 2014 Apr; 141(7): 1480-91. PMID: 24574008, PMCID: PMC3957372, PII: dev.098657, DOI: 10.1242/dev.098657, ISSN: 1477-9129.

von Figura G, Morris JP, Wright CV, Hebrok M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut [print-electronic]. 2014 Apr; 63(4): 656-64. PMID: 23645620, PMCID: PMC3883808, PII: gutjnl-2012-304287, DOI: 10.1136/gutjnl-2012-304287, ISSN: 1468-3288.

Rieck S, Wright C. PIQ-ing into chromatin architecture. Nat. Biotechnol. 2014 Feb; 32(2): 138-40. PMID: 24509760, PII: nbt.2824, DOI: 10.1038/nbt.2824, ISSN: 1546-1696.

Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nat Commun. 2014; 5: 3337. PMID: 24535035, PII: ncomms4337, DOI: 10.1038/ncomms4337, ISSN: 2041-1723.

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat. Biotechnol [print-electronic]. 2014 Jan; 32(1): 76-83. PMID: 24240391, PMCID: PMC4096987, PII: nbt.2747, DOI: 10.1038/nbt.2747, ISSN: 1546-1696.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology [print-electronic]. 2014 Jan; 146(1): 233-44.e5. PMID: 23999170, PMCID: PMC3870045, PII: S0016-5085(13)01273-0, DOI: 10.1053/j.gastro.2013.08.053, ISSN: 1528-0012.

Fleming JT, He W, Hao C, Ketova T, Pan FC, Wright CC, Litingtung Y, Chiang C. The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Dev. Cell. 2013 Nov 11/11/2013; 27(3): 278-92. PMID: 24229643, PMCID: PMC3860749, PII: S1534-5807(13)00605-9, DOI: 10.1016/j.devcel.2013.10.008, ISSN: 1878-1551.

Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes [print-electronic]. 2013 Oct; 62(10): 3459-68. PMID: 23775765, PMCID: PMC3781453, PII: db12-1833, DOI: 10.2337/db12-1833, ISSN: 1939-327X.

Lawson AK, Wright CV, Fitzgerald LF. The evaluation of sexual harassment litigants: reducing discrepancies in the diagnosis of posttraumatic stress disorder. Law Hum Behav [print-electronic]. 2013 Oct; 37(5): 337-47. PMID: 23544390, PII: 2013-11405-001, DOI: 10.1037/lhb0000024, ISSN: 1573-661X.

Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CV, Gu G, Kim SK. Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 Jul 7/30/2013; 110(31): 12691-6. PMID: 23852729, PMCID: PMC3732989, PII: 1304507110, DOI: 10.1073/pnas.1304507110, ISSN: 1091-6490.

Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD. Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development [print-electronic]. 2013 Jul; 140(13): 2669-79. PMID: 23720049, PMCID: PMC3678338, PII: dev.090993, DOI: 10.1242/dev.090993, ISSN: 1477-9129.

Liu J, Willet SG, Bankaitis ED, Xu Y, Wright CV, Gu G. Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis [print-electronic]. 2013 Jun; 51(6): 436-42. PMID: 23441020, PMCID: PMC3696028, DOI: 10.1002/dvg.22384, ISSN: 1526-968X.

Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development [print-electronic]. 2013 Feb; 140(4): 751-64. PMID: 23325761, PMCID: PMC3557774, PII: dev.090159, DOI: 10.1242/dev.090159, ISSN: 1477-9129.

Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell [print-electronic]. 2012 Dec 12/11/2012; 22(6): 737-50. PMID: 23201164, PMCID: PMC3568632, PII: S1535-6108(12)00449-7, DOI: 10.1016/j.ccr.2012.10.025, ISSN: 1878-3686.

Rieck S, Bankaitis ED, Wright CV. Lineage determinants in early endocrine development. Semin. Cell Dev. Biol [print-electronic]. 2012 Aug; 23(6): 673-84. PMID: 22728667, PMCID: PMC3922538, PII: S1084-9521(12)00115-2, DOI: 10.1016/j.semcdb.2012.06.005, ISSN: 1096-3634.

Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis [print-electronic]. 2012 Apr; 50(4): 384-92. PMID: 21913313, PMCID: PMC3870909, DOI: 10.1002/dvg.20804, ISSN: 1526-968X.

Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev. Biol [print-electronic]. 2012 Feb 2/1/2012; 362(1): 57-64. PMID: 22146645, PMCID: PMC3254730, PII: S0012-1606(11)01392-3, DOI: 10.1016/j.ydbio.2011.11.010, ISSN: 1095-564X.

Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV. Context-specific a- to-ß-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011 Aug 8/15/2011; 25(16): 1680-5. PMID: 21852533, PMCID: PMC3165933, PII: 25/16/1680, DOI: 10.1101/gad.16875711, ISSN: 1549-5477.

Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol. Cell. Endocrinol [print-electronic]. 2011 Jun 6/6/2011; 339(1-2): 144-50. PMID: 21539888, PMCID: PMC3112273, PII: S0303-7207(11)00206-1, DOI: 10.1016/j.mce.2011.04.008, ISSN: 1872-8057.

Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev. Dyn. 2011 Mar; 240(3): 530-65. PMID: 21337462, DOI: 10.1002/dvdy.22584, ISSN: 1097-0177.

Marjoram L, Wright C. Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus. Development. 2011 Feb; 138(3): 475-85. PMID: 21205792, PMCID: PMC3014634, PII: 138/3/475, DOI: 10.1242/dev.056010, ISSN: 1477-9129.

Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G. Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev. Biol [print-electronic]. 2010 Mar 3/1/2010; 339(1): 26-37. PMID: 20025861, PMCID: PMC2824035, PII: S0012-1606(09)01398-0, DOI: 10.1016/j.ydbio.2009.12.009, ISSN: 1095-564X.

Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J. Biol. Chem [print-electronic]. 2009 Nov 11/6/2009; 284(45): 31236-48. PMID: 19759004, PMCID: PMC2781522, PII: M109.048694, DOI: 10.1074/jbc.M109.048694, ISSN: 1083-351X.

Betley JN, Wright CV, Kawaguchi Y, Erdélyi F, Szabó G, Jessell TM, Kaltschmidt JA. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell. 2009 Oct 10/2/2009; 139(1): 161-74. PMID: 19804761, PMCID: PMC2812434, PII: S0092-8674(09)01048-4, DOI: 10.1016/j.cell.2009.08.027, ISSN: 1097-4172.

Skuntz S, Mankoo B, Nguyen MT, Hustert E, Nakayama A, Tournier-Lasserve E, Wright CV, Pachnis V, Bharti K, Arnheiter H. Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev. Biol [print-electronic]. 2009 Aug 8/15/2009; 332(2): 383-95. PMID: 19520072, PMCID: PMC2898144, PII: S0012-1606(09)00917-8, DOI: 10.1016/j.ydbio.2009.06.006, ISSN: 1095-564X.

Yang YP, Wright C. Chemicals turn human embryonic stem cells towards beta cells. Nature chemical biology. 2009 Apr; 5(4) Sect. 195,6.

Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S. Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice. Diabetes [print-electronic]. 2008 Sep; 57(9): 2421-31. PMID: 18591390, PMCID: PMC2518493, PII: db07-1558, DOI: 10.2337/db07-1558, ISSN: 1939-327X.

Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev. Biol [print-electronic]. 2008 Apr 4/1/2008; 316(1): 74-86. PMID: 18294628, PMCID: PMC2425677, PII: S0012-1606(08)00034-1, DOI: 10.1016/j.ydbio.2008.01.011, ISSN: 1095-564X.

Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev. Biol [print-electronic]. 2008 Feb 2/15/2008; 314(2): 406-17. PMID: 18155690, PMCID: PMC2269701, PII: S0012-1606(07)01464-9, DOI: 10.1016/j.ydbio.2007.10.038, ISSN: 1095-564X.

Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B, Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK, Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008; 4(7): e1000137. PMID: 18654634, PMCID: PMC2464733, DOI: 10.1371/journal.pgen.1000137, ISSN: 1553-7404.

Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J. Biol. Chem [print-electronic]. 2007 Nov 11/2/2007; 282(44): 32084-92. PMID: 17761679, PII: M700899200, DOI: 10.1074/jbc.M700899200, ISSN: 0021-9258.

Westmoreland JJ, Takahashi S, Wright CV. Xenopus Lefty requires proprotein cleavage but not N-linked glycosylation to inhibit nodal signaling. Dev. Dyn. 2007 Aug; 236(8): 2050-61. PMID: 17584861, DOI: 10.1002/dvdy.21210, ISSN: 1058-8388.

Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol. Cell. Biol [print-electronic]. 2007 Jun; 27(11): 4093-104. PMID: 17403901, PMCID: PMC1900007, PII: MCB.01978-06, DOI: 10.1128/MCB.01978-06, ISSN: 0270-7306.

Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME. Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev. Biol [print-electronic]. 2007 Apr 4/15/2007; 304(2): 786-99. PMID: 17320068, PII: S0012-1606(07)00063-2, DOI: 10.1016/j.ydbio.2007.01.027, ISSN: 0012-1606.

Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok M, Lewis BC. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Mar 3/20/2007; 104(12): 5103-8. PMID: 17372229, PMCID: PMC1828712, PII: 0701158104, DOI: 10.1073/pnas.0701158104, ISSN: 0027-8424.

Pascual M, Abasolo I, Mingorance-Le Meur A, Martínez A, Del Rio JA, Wright CV, Real FX, Soriano E. Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Mar 3/20/2007; 104(12): 5193-8. PMID: 17360405, PMCID: PMC1829285, PII: 0605699104, DOI: 10.1073/pnas.0605699104, ISSN: 0027-8424.

Ohi Y, Wright CV. Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. Dev. Biol [print-electronic]. 2007 Jan 1/15/2007; 301(2): 447-63. PMID: 16959238, PMCID: PMC2567117, PII: S0012-1606(06)01091-8, DOI: 10.1016/j.ydbio.2006.08.021, ISSN: 0012-1606.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev. 2006 Nov 11/15/2006; 20(22): 3147-60. PMID: 17114585, PMCID: PMC1635149, PII: 20/22/3147, DOI: 10.1101/gad.1475506, ISSN: 0890-9369.

Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006 Nov; 133(22): 4439-50. PMID: 17075007, PII: 133/22/4439, DOI: 10.1242/dev.02598, ISSN: 0950-1991.

Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev. Biol [print-electronic]. 2006 Oct 10/15/2006; 298(2): 616-31. PMID: 16962573, PII: S0012-1606(06)01026-8, DOI: 10.1016/j.ydbio.2006.07.020, ISSN: 0012-1606.

Takahashi S, Onuma Y, Yokota C, Westmoreland JJ, Asashima M, Wright CV. Nodal-related gene Xnr5 is amplified in the Xenopus genome. Genesis. 2006 Jul; 44(7): 309-21. PMID: 16791846, DOI: 10.1002/dvg.20217, ISSN: 1526-954X.

Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV, Fujitani Y. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 2006 Jun 6/1/2006; 20(11): 1435-40. PMID: 16751181, PMCID: PMC1475756, PII: 20/11/1435, DOI: 10.1101/gad.1412806, ISSN: 0890-9369.

Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T. Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J. Clin. Invest [print-electronic]. 2006 Jun; 116(6): 1484-93. PMID: 16710472, PMCID: PMC1462947, DOI: 10.1172/JCI27704, ISSN: 0021-9738.

Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Kuhara T, Horiguchi M, Koizumi M, Fujimoto K, Doi R, Wright CV, Chiba T. Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Gastroenterology. 2006 Mar; 130(3): 855-67. PMID: 16530524, PII: S0016-5085(05)02316-4, DOI: 10.1053/j.gastro.2005.11.031, ISSN: 0016-5085.

Cha YR, Takahashi S, Wright CV. Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. Dev. Biol [print-electronic]. 2006 Feb 2/15/2006; 290(2): 246-64. PMID: 16405884, PII: S0012-1606(05)00774-8, DOI: 10.1016/j.ydbio.2005.10.043, ISSN: 0012-1606.

Ripley AN, Osler ME, Wright CV, Bader D. Xbves is a regulator of epithelial movement during early Xenopus laevis development. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Jan 1/17/2006; 103(3): 614-9. PMID: 16407138, PMCID: PMC1334639, PII: 0506095103, DOI: 10.1073/pnas.0506095103, ISSN: 0027-8424.

Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006 Jan 1/15/2006; 20(2): 253-66. PMID: 16418487, PMCID: PMC1356115, PII: 20/2/253, DOI: 10.1101/gad.1360106, ISSN: 0890-9369.

Hruban RH, Rustgi AK, Brentnall TA, Tempero MA, Wright CV, Tuveson DA. Pancreatic cancer in mice and man: the Penn Workshop 2004. Cancer Res. 2006 Jan 1/1/2006; 66(1): 14-7. PMID: 16397208, PII: 66/1/14, DOI: 10.1158/0008-5472.CAN-05-3914, ISSN: 0008-5472.

Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P, . Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev. Biol [print-electronic]. 2005 Dec 12/15/2005; 288(2): 487-501. PMID: 16297379, PII: S0012-1606(05)00707-4, DOI: 10.1016/j.ydbio.2005.10.001, ISSN: 0012-1606.

Glasgow SM, Henke RM, Macdonald RJ, Wright CV, Johnson JE. Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn. Development [print-electronic]. 2005 Dec; 132(24): 5461-9. PMID: 16291784, PII: dev.02167, DOI: 10.1242/dev.02167, ISSN: 0950-1991.

Chea HK, Wright CV, Swalla BJ. Nodal signaling and the evolution of deuterostome gastrulation. Dev. Dyn. 2005 Oct; 234(2): 269-78. PMID: 16127715, DOI: 10.1002/dvdy.20549, ISSN: 1058-8388.

Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ, Wright CV, Stoffers DA, Leach SD. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development [print-electronic]. 2005 Aug; 132(16): 3767-76. PMID: 16020518, PII: dev.01925, DOI: 10.1242/dev.01925, ISSN: 0950-1991.

Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CV, Kawaguchi Y, Nakao K, Nabeshima Y. Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron. 2005 Jul 7/21/2005; 47(2): 201-13. PMID: 16039563, PII: S0896-6273(05)00485-X, DOI: 10.1016/j.neuron.2005.06.007, ISSN: 0896-6273.

Zhang H, Fujitani Y, Wright CV, Gannon M. Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase. Genesis. 2005 Jul; 42(3): 210-7. PMID: 15986486, DOI: 10.1002/gene.20137, ISSN: 1526-954X.

Mead PE, Parganas E, Ohtsuka S, Morishita K, Gamer L, Kuliyev E, Wright CV, Ihle JN. Evi-1 expression in Xenopus. Gene Expr. Patterns. 2005 Jun; 5(5): 601-8. PMID: 15905132, PII: S1567-133X(05)00030-X, DOI: 10.1016/j.modgep.2005.03.007, ISSN: 1567-133X.

Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ, Goldenring JR. Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology. 2005 May; 128(5): 1292-305. PMID: 15887112, PII: S0016508505004038, ISSN: 0016-5085.

Means AL, Chytil A, Moses HL, Coffey RJ, Wright CV, Taketo MM, Grady WM. Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis. 2005 May; 42(1): 23-7. PMID: 15828001, DOI: 10.1002/gene.20119, ISSN: 1526-954X.

Brissova M, Blaha M, Spear C, Nicholson W, Radhika A, Shiota M, Charron MJ, Wright CV, Powers AC. Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2005 Apr; 288(4): E707-14. PMID: 15562255, PII: 00252.2004, DOI: 10.1152/ajpendo.00252.2004, ISSN: 0193-1849.

Jepeal LI, Fujitani Y, Boylan MO, Wilson CN, Wright CV, Wolfe MM. Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology [print-electronic]. 2005 Jan; 146(1): 383-91. PMID: 15486225, PII: en.2004-0223, DOI: 10.1210/en.2004-0223, ISSN: 0013-7227.

Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec; 4(6): 437-50. PMID: 14706336, PII: S153561080300309X, ISSN: 1535-6108.

Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R, Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T. Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J. Biol. Chem [print-electronic]. 2003 Oct 10/31/2003; 278(44): 43691-8. PMID: 12869553, PII: M307004200, DOI: 10.1074/jbc.M307004200, ISSN: 0021-9258.

Mankoo BS, Skuntz S, Harrigan I, Grigorieva E, Candia A, Wright CV, Arnheiter H, Pachnis V. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development. 2003 Oct; 130(19): 4655-64. PMID: 12925591, PII: 130/19/4655, DOI: 10.1242/dev.00687, ISSN: 0950-1991.

Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology. 2003 Apr; 124(4): 1020-36. PMID: 12671899, PII: S0016508503000647, DOI: 10.1053/gast.2003.50150, ISSN: 0016-5085.

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 2002 Dec; 110(12): 1839-47. PMID: 12488434, PMCID: PMC151657, DOI: 10.1172/JCI16857, ISSN: 0021-9738.

Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet [print-electronic]. 2002 Oct; 32(2): 245-53. PMID: 12219087, PII: ng890, DOI: 10.1038/ng890, ISSN: 1061-4036.

Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet [print-electronic]. 2002 Sep; 32(1): 128-34. PMID: 12185368, PII: ng959, DOI: 10.1038/ng959, ISSN: 1061-4036.

Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol. Cell. Biol. 2002 Jul; 22(13): 4702-13. PMID: 12052878, PMCID: PMC133887, ISSN: 0270-7306.

Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. J. Clin. Invest. 2002 May; 109(9): 1193-201. PMID: 11994408, PMCID: PMC150960, DOI: 10.1172/JCI14439, ISSN: 0021-9738.

Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J. Biol. Chem [print-electronic]. 2002 Mar 3/29/2002; 277(13): 11225-32. PMID: 11781323, PII: M111272200, DOI: 10.1074/jbc.M111272200, ISSN: 0021-9258.

Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc. Natl. Acad. Sci. U.S.A. 2002 Mar 3/19/2002; 99(6): 3818-23. PMID: 11904435, PMCID: PMC122607, PII: 99/6/3818, DOI: 10.1073/pnas.062605899, ISSN: 0027-8424.

Chytil A, Magnuson MA, Wright CV, Moses HL. Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb; 32(2): 73-5. PMID: 11857781, PII: 10.1002/gene.10046, ISSN: 1526-954X.

Wright CV, Halpern ME. Specification of left-right asymmetry. Results Probl Cell Differ. 2002; 40: 96-116. PMID: 12353488, ISSN: 0080-1844.

Gannon M, Gamer LW, Wright CV. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev. Biol. 2001 Oct 10/1/2001; 238(1): 185-201. PMID: 11784003, PII: S0012-1606(01)90359-8, DOI: 10.1006/dbio.2001.0359, ISSN: 0012-1606.

Erter CE, Wilm TP, Basler N, Wright CV, Solnica-Krezel L. Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development. 2001 Sep; 128(18): 3571-83. PMID: 11566861, ISSN: 0950-1991.

Wright CV. Mechanisms of left-right asymmetry: what's right and what's left?. Dev. Cell. 2001 Aug; 1(2): 179-86. PMID: 11702778, PII: S1534-5807(01)00036-3, ISSN: 1534-5807.

Dutta S, Gannon MA, Peers B, Wright CVE, Bonner-Weir S, Montminy M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. PNAS. 2001; 98((3)): 1065-70.

Hui, H., Wright, C.V.E. and Perfetti, R. GLP-1 induces differentiation of IDX-1 positive pancreatic ductal cells into insulin secreting cell. Diabetes. 2001; 50: 785-96.

Wright CVE, Cheng AMS, Osada S, Hamada H. Negative feedback inhibiting Nodal signalling during asymmetrical morphogenesis. HFSP Workshop 10 Report. 2001.

Gonzalez EM, Fekany-Lee K, Carmany-Rampey A, Erter C, Topczewski J, Wright CV, Solnica-Krezel L. Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino. Genes Dev. 2000 Dec 12/15/2000; 14(24): 3087-92. PMID: 11124801, PMCID: PMC317122, ISSN: 0890-9369.

Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development. 2000 Jul; 127(13): 2883-95. PMID: 10851133, ISSN: 0950-1991.

Osada SI, Saijoh Y, Frisch A, Yeo CY, Adachi H, Watanabe M, Whitman M, Hamada H, Wright CV. Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1. Development. 2000 Jun; 127(11): 2503-14. PMID: 10804190, ISSN: 0950-1991.

Cheng AM, Thisse B, Thisse C, Wright CV. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Development. 2000 Mar; 127(5): 1049-61. PMID: 10662644, ISSN: 0950-1991.

Gerrish K, Gannon M, Shih D, Henderson E, Stoffel M, Wright CV, Stein R. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. J. Biol. Chem. 2000 Feb 2/4/2000; 275(5): 3485-92. PMID: 10652343, ISSN: 0021-9258.

Gannon M, Herrera PL, Wright CV. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis. 2000 Feb; 26(2): 143-4. PMID: 10686611, PII: 10.1002/(SICI)1526-968X(200002)26:2<143::AID-GENE13>3.0.CO;2-L, ISSN: 1526-954X.

Gannon M, Shiota C, Postic C, Wright CV, Magnuson M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis. 2000 Feb; 26(2): 139-42. PMID: 10686610, PII: 10.1002/(SICI)1526-968X(200002)26:2<139::AID-GENE12>3.0.CO;2-7, ISSN: 1526-954X.

Thisse B, Wright CV, Thisse C. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature. 2000 Jan 1/27/2000; 403(6768): 425-8. PMID: 10667793, DOI: 10.1038/35000200, ISSN: 0028-0836.

Ishimaru Y, Yoshioka H, Tao H, Thisse B, Thisse C, Wright CVE, Hamada H, Ohuchi H, Noji S. Asymmetric expression of antivin/lefty-1 in the early chick embryo. Mechanisms of Development. 2000; 90((1)): 115-8.

Schumpert B, Keefer A, Wright CVE, Swalla BJ. Evolution of Left-Right Asymmetry: Expression of Ascidian Nodal. Amer. Zool. 2000; 39: 77A#456.

Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology. 1999 Dec; 117(6): 1416-26. PMID: 10579983, PII: S0016508599005648, ISSN: 0016-5085.

Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V. Mox2 is a component of the genetic hierarchy controlling limb muscle development. Nature. 1999 Jul 7/1/1999; 400(6739): 69-73. PMID: 10403250, DOI: 10.1038/21892, ISSN: 0028-0836.

Osada SI, Wright CV. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development. 1999 Jun; 126(14): 3229-40. PMID: 10375512, ISSN: 0950-1991.

Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL. Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Genes Dev. 1999 Feb 2/15/1999; 13(4): 424-36. PMID: 10049358, PMCID: PMC316469, ISSN: 0890-9369.

Gannon, M., K. Gerrish, R. Stein and C.V.E. Wright. Pdx-1 in pancreas development and glucose homeostasis. American Diabetes Association, Proceedings of the Scottsdale meeting on MODY genes. Pub. Karger Press. Eds. F. Matschinsky and M. Magnuson. 1999.

Kritzik, M.R., Jones, E., Chen, Z., Krakowski, M., Krahl, T., Good, A., Wright, C.V.E., Fox, H., and Sarvetnick, N. PDX-1 and msx-2 expression in the regenerating and developing pancreas. J. Endocrinology. 1999; 163((3)): 523-30.

Koffron M, Demel T, Xanthos J, Lohr J, Sive H, Osada S-I, Wright CVE, Wylie C, Heasman J. Medoserm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors. Development. 1999; 126((24)): 5759-70.

Erter CE, Solnica-Krezel L, Wright CV. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Dev. Biol. 1998 Dec 12/15/1998; 204(2): 361-72. PMID: 9882476, PII: S0012-1606(98)99097-2, DOI: 10.1006/dbio.1998.9097, ISSN: 0012-1606.

Sampath K, Rubinstein AL, Cheng AM, Liang JO, Fekany K, Solnica-Krezel L, Korzh V, Halpern ME, Wright CV. Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature. 1998 Sep 9/10/1998; 395(6698): 185-9. PMID: 9744278, DOI: 10.1038/26020, ISSN: 0028-0836.

Swift GH, Liu Y, Rose SD, Bischof LJ, Steelman S, Buchberg AM, Wright CV, MacDonald RJ. An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2). Mol. Cell. Biol. 1998 Sep; 18(9): 5109-20. PMID: 9710595, PMCID: PMC109096, ISSN: 0270-7306.

Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA. Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 1998 Jul 7/21/1998; 95(15): 8654-9. PMID: 9671733, PMCID: PMC21131, ISSN: 0027-8424.

Wright CV. Lateral asymmetry in multicellular organisms. Semin. Cell Dev. Biol. 1998 Feb; 9(1): 31-3. PMID: 9572111, PII: S1084952197901981, ISSN: 1084-9521.

Frisch A, Wright CV. XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues. Development. 1998 Feb; 125(3): 431-42. PMID: 9425138, ISSN: 0950-1991.

Dutta, S., Bonner-Weir, S., Montminy, M. and Wright, C.V.E. Regulatory factor linked to late-onset diabetes?. Nature. 1998; 392: 560.

Gannon M, Wright CVE. Endodermal patterning and organogenesis. Cell Lineage and Fate Determination. 1998; S. Moody Ed.((San Diego: Academic Press)): 583-615.

Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol. Cell. Biol. 1997 Oct; 17(10): 6002-13. PMID: 9315659, PMCID: PMC232449, ISSN: 0270-7306.

Sampath K, Cheng AM, Frisch A, Wright CV. Functional differences among Xenopus nodal-related genes in left-right axis determination. Development. 1997 Sep; 124(17): 3293-302. PMID: 9310324, ISSN: 0950-1991.

Peshavaria M, Henderson E, Sharma A, Wright CV, Stein R. Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol. Cell. Biol. 1997 Jul; 17(7): 3987-96. PMID: 9199333, PMCID: PMC232251, ISSN: 0270-7306.

Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology. 1997 Apr; 138(4): 1750-62. PMID: 9075740, DOI: 10.1210/endo.138.4.5049, ISSN: 0013-7227.

Woychik R, Hogan B, Bryant S, Eichele G, Kimelman D, Noden D, Schoenwolf G, Wright C. Pattern formation. Reproductive Toxicology. 1997; 11((2-3)): 339-44.

Candia AF, Wright CV. Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. Int. J. Dev. Biol. 1996 Dec; 40(6): 1179-84. PMID: 9032023, ISSN: 0214-6282.

Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn MR. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature. 1996 May 5/9/1996; 381(6578): 158-61. PMID: 8610013, DOI: 10.1038/381158a0, ISSN: 0028-0836.

Jones CM, Dale L, Hogan BL, Wright CV, Smith JC. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Development. 1996 May; 122(5): 1545-54. PMID: 8625841, ISSN: 0950-1991.

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar; 122(3): 983-95. PMID: 8631275, ISSN: 0950-1991.

Jones CM, Kuehn MR, Hogan BL, Smith JC, Wright CV. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development. 1995 Nov; 121(11): 3651-62. PMID: 8582278, ISSN: 0950-1991.

Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, Stein R. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc. Natl. Acad. Sci. U.S.A. 1995 Sep 9/26/1995; 92(20): 9127-31. PMID: 7568086, PMCID: PMC40937, ISSN: 0027-8424.

Gamer LW, Wright CV. Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8. Dev. Biol. 1995 Sep; 171(1): 240-51. PMID: 7556900, PII: S0012-1606(85)71275-4, DOI: 10.1006/dbio.1995.1275, ISSN: 0012-1606.

Zhang X, Wright CV, Hanks SK. Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development. Gene. 1995 Jul 7/28/1995; 160(2): 219-22. PMID: 7642098, PII: 037811199500153W, ISSN: 0378-1119.

Candia AF, Wright CV. The expression pattern of Xenopus Mox-2 implies a role in initial mesodermal differentiation. Mech. Dev. 1995 Jul; 52(1): 27-36. PMID: 7577672, PII: 092547739500384D, ISSN: 0925-4773.

Stoffel M, Stein R, Wright CV, Espinosa R, Le Beau MM, Bell GI. Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1. Genomics. 1995 Jul 7/1/1995; 28(1): 125-6. PMID: 7590740, PII: S0888754385711202, ISSN: 0888-7543.

Toyama R, O'Connell ML, Wright CV, Kuehn MR, Dawid IB. Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development. 1995 Feb; 121(2): 383-91. PMID: 7768180, ISSN: 0950-1991.

Conlon FL, Wright CV, Robertson EJ. Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech. Dev. 1995 Feb; 49(3): 201-9. PMID: 7734393, PII: 092547739400318H, ISSN: 0925-4773.

Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development. 1995 Jan; 121(1): 11-8. PMID: 7867492, ISSN: 0950-1991.

Pierceall WE, Reale MA, Candia AF, Wright CV, Cho KR, Fearon ER. Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Dev. Biol. 1994 Dec; 166(2): 654-65. PMID: 7813784, PII: S0012-1606(84)71345-5, DOI: 10.1006/dbio.1994.1345, ISSN: 0012-1606.

Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CV, Stein R. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol. Endocrinol. 1994 Jun; 8(6): 806-16. PMID: 7935494, DOI: 10.1210/mend.8.6.7935494, ISSN: 0888-8809.

Barnes JD, Crosby JL, Jones CM, Wright CV, Hogan BL. Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol. 1994 Jan; 161(1): 168-78. PMID: 7904966, PII: S0012-1606(84)71018-9, DOI: 10.1006/dbio.1994.1018, ISSN: 0012-1606.

Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R. The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. Development. 1994 Jan; 120(1): 165-75. PMID: 8119124, ISSN: 0950-1991.

Candia AF, Kovalik JP, Wright CV. Amino acid sequence of Mox-2 and comparison to its Xenopus and rat homologs. Nucleic Acids Res. 1993 Oct 10/25/1993; 21(21): 4982. PMID: 7909944, PMCID: PMC311417, ISSN: 0305-1048.

Gamer LW, Wright CV. Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech. Dev. 1993 Sep; 43(1): 71-81. PMID: 7902125, PII: 0925-4773(93)90024-R, ISSN: 0925-4773.

Wright CV. Hox genes and the hindbrain. Curr. Biol. 1993 Sep 9/1/1993; 3(9): 618-21. PMID: 15335681, PII: 0960-9822(93)90013-E, ISSN: 0960-9822.

Wall NA, Blessing M, Wright CV, Hogan BL. Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J. Cell Biol. 1993 Jan; 120(2): 493-502. PMID: 8421061, PMCID: PMC2119526, ISSN: 0021-9525.

Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau JH, Wright CV. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec; 116(4): 1123-36. PMID: 1363541, ISSN: 0950-1991.

Jegalian BG, Miller RW, Wright CV, Blum M, De Robertis EM. A Hox 3.3-lacZ transgene expressed in developing limbs. Mech. Dev. 1992 Dec; 39(3): 171-80. PMID: 1292571, ISSN: 0925-4773.

Jones CM, Lyons KM, Lapan PM, Wright CV, Hogan BL. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development. 1992 Jun; 115(2): 639-47. PMID: 1425343, ISSN: 0950-1991.

Wall NA, Jones CM, Hogan BL, Wright CV. Expression and modification of Hox 2.1 protein in mouse embryos. Mech. Dev. 1992 May; 37(3): 111-20. PMID: 1353982, ISSN: 0925-4773.

Hogan B, Wright C. The making of the ear. Nature. 1992; 355((Feb 06)): 494-5.

Wright PF, Kim-Farley RJ, de Quadros CA, Robertson SE, Scott RM, Ward NA, Henderson RH. Strategies for the global eradication of poliomyelitis by the year 2000. N. Engl. J. Med. 1991 Dec 12/19/1991; 325(25): 1774-9. PMID: 1719418, DOI: 10.1056/NEJM199112193252504, ISSN: 0028-4793.

Wright CV. Vertebrate homeobox genes. Curr. Opin. Cell Biol. 1991 Dec; 3(6): 976-82. PMID: 1687652, ISSN: 0955-0674.

Blumberg B, Wright CV, De Robertis EM, Cho KW. Organizer-specific homeobox genes in Xenopus laevis embryos. Science. 1991 Jul 7/12/1991; 253(5016): 194-6. PMID: 1677215, ISSN: 0036-8075.

Cho KW, Morita EA, Wright CV, De Robertis EM. Overexpression of a homeodomain protein confers axis-forming activity to uncommitted Xenopus embryonic cells. Cell. 1991 Apr 4/5/1991; 65(1): 55-64. PMID: 1672833, PII: 0092-8674(91)90407-P, ISSN: 0092-8674.

Wright C, Hogan B. Another hit for gene targeting. Nature. 1991; 350((11 April)): 458-9.

De Robertis EM, Oliver G, Wright CV. Homeobox genes and the vertebrate body plan. Sci. Am. 1990 Jul; 263(1): 46-52. PMID: 1973846, ISSN: 0036-8733.

Cridland NA, Wright CV, McKenzie EA, Knowland J. Selective photochemical treatment of oestrogen receptor in a Xenopus liver extract destroys hormone binding and transcriptional activation but not DNA binding. EMBO J. 1990 Jun; 9(6): 1859-66. PMID: 2347307, PMCID: PMC551891, ISSN: 0261-4189.

Molven A, Wright CV, Bremiller R, De Robertis EM, Kimmel CB. Expression of a homeobox gene product in normal and mutant zebrafish embryos: evolution of the tetrapod body plan. Development. 1990 Jun; 109(2): 279-88. PMID: 1976086, ISSN: 0950-1991.

Wright CV, Morita EA, Wilkin DJ, De Robertis EM. The Xenopus XIHbox 6 homeo protein, a marker of posterior neural induction, is expressed in proliferating neurons. Development. 1990 May; 109(1): 225-34. PMID: 1976504, ISSN: 0950-1991.

Wright CV, Cho KW, Hardwicke J, Collins RH, De Robertis EM. Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord. Cell. 1989 Oct 10/6/1989; 59(1): 81-93. PMID: 2477158, PII: 0092-8674(89)90871-4, ISSN: 0092-8674.

De Robertis EM, Oliver G, Wright CV. Determination of axial polarity in the vertebrate embryo: homeodomain proteins and homeogenetic induction. Cell. 1989 Apr 4/21/1989; 57(2): 189-91. PMID: 2564812, PII: 0092-8674(89)90954-9, ISSN: 0092-8674.

Wright CV, Schnegelsberg P, De Robertis EM. XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm. Development. 1989 Apr; 105(4): 787-94. PMID: 2574662, ISSN: 0950-1991.

Wright CV, Cho KW, Oliver G, De Robertis EM. Vertebrate homeodomain proteins: families of region-specific transcription factors. Trends Biochem. Sci. 1989 Feb; 14(2): 52-6. PMID: 2565051, ISSN: 0968-0004.

Fritz AF, Cho KW, Wright CV, Jegalian BG, De Robertis EM. Duplicated homeobox genes in Xenopus. Dev. Biol. 1989 Feb; 131(2): 584-8. PMID: 2563247, ISSN: 0012-1606.

Oliver G, Wright CV, Hardwicke J, De Robertis EM. A gradient of homeodomain protein in developing forelimbs of Xenopus and mouse embryos. Cell. 1988 Dec 12/23/1988; 55(6): 1017-24. PMID: 2904837, PII: 0092-8674(88)90246-2, ISSN: 0092-8674.

De Robertis EM, Burglin TR, Fritz A, Oliver G, Cho K, Wright CV. Sequence conservations in vertebrate homeo-box mRNAs. Arch. Biol. Med. Exp. 1988 Dec; 21(3-4): 443-7. PMID: 2908262, ISSN: 0004-0533.

Oliver G, Wright CV, Hardwicke J, De Robertis EM. Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos. EMBO J. 1988 Oct; 7(10): 3199-209. PMID: 2460338, PMCID: PMC454715, ISSN: 0261-4189.

Fritz AF, Martin G, Wright CV, De Robertis EM. Site-specific inversions in repeated Xenopus laevis homeobox gene 2 sequences. Nucleic Acids Res. 1988 Sep 9/26/1988; 16(18): 9058. PMID: 2902559, PMCID: PMC338668, ISSN: 0305-1048.

Cho KW, Goetz J, Wright CV, Fritz A, Hardwicke J, De Robertis EM. Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. EMBO J. 1988 Jul; 7(7): 2139-49. PMID: 2901347, PMCID: PMC454519, ISSN: 0261-4189.

De Robertis EM, Buerglin TR, Fritz A, Wright CVE, Jegalian B, Schnegelsberg P, Bittner D, Morita E, Oliver G, Cho KWY. Families of vertebrate homeodomain proteins. UCLA Symposia "DNA-Protein Interactions in Transcription" Ed. J. Gralla. 1988; 95: 107-16.

Oliver G, Wright CVE, Cho KWY, De Robertis E. Characterization and distributional analysis of a homeobox-containing gene in Xenopus and mouse embryos. NATO ASI Series. 1988; ((Cell to Cell Signals in Development)).

Bürglin TR, Wright CV, De Robertis EM. Translational control in homoeobox mRNAs? [letter]. Nature. 1987 Dec 12/24/1987; 330(6150): 701-2. PMID: 2892138, DOI: 10.1038/330701c0, ISSN: 0028-0836.

Wright CV, Cho KW, Fritz A, Bürglin TR, De Robertis EM. A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts. EMBO J. 1987 Dec 12/20/1987; 6(13): 4083-94. PMID: 2894983, PMCID: PMC553891, ISSN: 0261-4189.

De Robertis EM, Fritz A, Goetz J, Matin G, Mattaj IW, Salo E, Smith GD, Wright C, Zeller R. The Xenopus homeo boxes. Cold Spring Harbor Symposia Quantitative Biology. 1985; ((L)): 271-5.

Knowland J, Theulaz I, Wright CV, Wahli W. Injection of partially purified estrogen receptor protein from Xenopus liver nuclei into oocytes activates the silent vitellogenin locus. Proc. Natl. Acad. Sci. U.S.A. 1984 Sep; 81(18): 5777-81. PMID: 6592586, PMCID: PMC391794, ISSN: 0027-8424.

Wright CV, Wright SC, Knowland J. Partial purification of estradiol receptor from Xenopus laevis liver and levels of receptor in relation to estradiol concentration. EMBO J. 1983; 2(6): 973-7. PMID: 6641722, PMCID: PMC555217, ISSN: 0261-4189.

Pancreatic plasticity and reprogramming ¿¿¿ novel directions towards disease therapy.

Available Postdoctoral Position Details
Posted: 7/28/2014
to study pancreas formation and function using state of the art genome manipulation techniques in vivo in mouse (knockout, knockin, transgenic) and in vitro cell culture models.