John H. Newman, M.D.

Professor

john.newman@vanderbilt.edu
Faculty Appointments
Professor of Medicine Elsa S. Hanigan Chair in Pulmonary Medicine
Education
M.D., Columbia University, New York, New YorkA.B., Harvard University, Cambridge, Massachusetts
Office Address
T 1218 Medical Center North
Nashville, TN 37232-2650
Publications
Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Apr 4/14/2016; PMID: 27077479, DOI: 10.1164/rccm.201507-1444OC, ISSN: 1535-4970.

Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Apr 4/14/2016; PMID: 27077479, DOI: 10.1164/rccm.201507-1444OC, ISSN: 1535-4970.

Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West J, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 Mar 3/22/2016; PMID: 27006481, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.

Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West J, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 Mar 3/22/2016; PMID: 27006481, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.

Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Feb 2/29/2016; PMID: 26926454, DOI: 10.1164/rccm.201508-1678OC, ISSN: 1535-4970.

Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Feb 2/29/2016; PMID: 26926454, DOI: 10.1164/rccm.201508-1678OC, ISSN: 1535-4970.

Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E. Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. Hum. Mutat [print-electronic]. 2015 Dec; 36(12): 1113-27. PMID: 26387786, PMCID: PMC4822159, DOI: 10.1002/humu.22904, ISSN: 1098-1004.

Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E. Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. Hum. Mutat [print-electronic]. 2015 Dec; 36(12): 1113-27. PMID: 26387786, PMCID: PMC4822159, DOI: 10.1002/humu.22904, ISSN: 1098-1004.

Mishra A, Mohammad G, Norboo T, Newman JH, Pasha MA. Lungs at high-altitude: genomic insights into hypoxic responses. J. Appl. Physiol [print-electronic]. 2015 Jul 7/1/2015; 119(1): 1-15. PMID: 25911686, PII: japplphysiol.00513.2014, DOI: 10.1152/japplphysiol.00513.2014, ISSN: 1522-1601.

Mishra A, Mohammad G, Norboo T, Newman JH, Pasha MA. Lungs at high-altitude: genomic insights into hypoxic responses. J. Appl. Physiol [print-electronic]. 2015 Jul 7/1/2015; 119(1): 1-15. PMID: 25911686, PII: japplphysiol.00513.2014, DOI: 10.1152/japplphysiol.00513.2014, ISSN: 1522-1601.

Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers. Pulm Circ. 2015 Jun; 5(2): 356-63. PMID: 26064462, PMCID: PMC4449248, PII: PC2013183, DOI: 10.1086/681264, ISSN: 2045-8932.

Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers. Pulm Circ. 2015 Jun; 5(2): 356-63. PMID: 26064462, PMCID: PMC4449248, PII: PC2013183, DOI: 10.1086/681264, ISSN: 2045-8932.

Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation [print-electronic]. 2015 Jan 1/27/2015; 131(4): 401-9; discussion 409. PMID: 25361553, PMCID: PMC4308423, PII: CIRCULATIONAHA.114.013317, DOI: 10.1161/CIRCULATIONAHA.114.013317, ISSN: 1524-4539.

Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation [print-electronic]. 2015 Jan 1/27/2015; 131(4): 401-9; discussion 409. PMID: 25361553, PMCID: PMC4308423, PII: CIRCULATIONAHA.114.013317, DOI: 10.1161/CIRCULATIONAHA.114.013317, ISSN: 1524-4539.

Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015; 6: 6863. PMID: 25873470, PMCID: PMC4399003, PII: ncomms7863, DOI: 10.1038/ncomms7863, ISSN: 2041-1723.

Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015; 6: 6863. PMID: 25873470, PMCID: PMC4399003, PII: ncomms7863, DOI: 10.1038/ncomms7863, ISSN: 2041-1723.

Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec; 4(4): 679-84. PMID: 25610603, PMCID: PMC4278627, PII: PC2013117, DOI: 10.1086/678514, ISSN: 2045-8932.

Newman JH. The first annual Drug Discovery and Development Symposium for Pulmonary Hypertension. Pulm Circ. 2014 Dec; 4(4): 533-4. PMID: 25610591, PMCID: PMC4278615, PII: PC2013198, DOI: 10.1086/679063, ISSN: 2045-8932.

Newman JH. The first annual Drug Discovery and Development Symposium for Pulmonary Hypertension. Pulm Circ. 2014 Dec; 4(4): 533-4. PMID: 25610591, PMCID: PMC4278615, PII: PC2013198, DOI: 10.1086/679063, ISSN: 2045-8932.

Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec; 4(4): 679-84. PMID: 25610603, PMCID: PMC4278627, PII: PC2013117, DOI: 10.1086/678514, ISSN: 2045-8932.

Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana RN, Fong PP, Newman JH. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail [print-electronic]. 2014 Jan; 7(1): 116-22. PMID: 24297689, PMCID: PMC3934572, PII: CIRCHEARTFAILURE.113.000468, DOI: 10.1161/CIRCHEARTFAILURE.113.000468, ISSN: 1941-3297.

Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana RN, Fong PP, Newman JH. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail [print-electronic]. 2014 Jan; 7(1): 116-22. PMID: 24297689, PMCID: PMC3934572, PII: CIRCHEARTFAILURE.113.000468, DOI: 10.1161/CIRCHEARTFAILURE.113.000468, ISSN: 1941-3297.

Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2013 Dec 12/24/2013; 62(25 Suppl): D13-21. PMID: 24355637, PII: S0735-1097(13)05878-6, DOI: 10.1016/j.jacc.2013.10.035, ISSN: 1558-3597.

Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2013 Dec 12/24/2013; 62(25 Suppl): D13-21. PMID: 24355637, PII: S0735-1097(13)05878-6, DOI: 10.1016/j.jacc.2013.10.035, ISSN: 1558-3597.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.

Bates MG, Hollingsworth KG, Newman JH, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. Eur Heart J Cardiovasc Imaging [print-electronic]. 2013 Jul; 14(7): 650-8. PMID: 23129433, PMCID: PMC3681541, PII: jes226, DOI: 10.1093/ehjci/jes226, ISSN: 2047-2412.

Bryant AJ, Newman JH. Alcohol intolerance associated with Hodgkin lymphoma. CMAJ [print-electronic]. 2013 May 5/14/2013; 185(8): E353. PMID: 23091182, PMCID: PMC3652965, PII: cmaj.120974, DOI: 10.1503/cmaj.120974, ISSN: 1488-2329.

Pugh ME, Newman JH, Williams DB, Brittain E, Robbins IM, Hemnes AR. Hemodynamic improvement of pulmonary arterial hypertension after bariatric surgery: potential role for metabolic regulation. Diabetes Care. 2013 Mar; 36(3): e32-3. PMID: 23431096, PMCID: PMC3579352, PII: 36/3/e32, DOI: 10.2337/dc12-1650, ISSN: 1935-5548.

Brittain EL, Pugh ME, Wang L, Newman AL, Robbins IM, Newman JH, Hemnes AR. Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension. PLoS ONE. 2013; 8(10): e76461. PMID: 24124561, PMCID: PMC3790694, PII: PONE-D-13-27489, DOI: 10.1371/journal.pone.0076461, ISSN: 1932-6203.

Newman JH, Elliott GC, Haworth GS, Zampaglione E, Brar S, Gibbs SJ, Sandoval J. Clinical trials in pulmonary hypertension: Time for a consortium. Pulm Circ. 2013 Jan; 3(1): 245-51. PMID: 23662202, PMCID: PMC3641735, PII: PC-3-245, DOI: 10.4103/2045-8932.109922, ISSN: 2045-8932.

Brittain EL, Pugh ME, Wang L, Newman AL, Robbins IM, Newman JH, Hemnes AR. Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension. PLoS ONE. 2013; 8(10): e76461. PMID: 24124561, PMCID: PMC3790694, PII: PONE-D-13-27489, DOI: 10.1371/journal.pone.0076461, ISSN: 1932-6203.

Newman JH, Elliott GC, Haworth GS, Zampaglione E, Brar S, Gibbs SJ, Sandoval J. Clinical trials in pulmonary hypertension: Time for a consortium. Pulm Circ. 2013 Jan; 3(1): 245-51. PMID: 23662202, PMCID: PMC3641735, PII: PC-3-245, DOI: 10.4103/2045-8932.109922, ISSN: 2045-8932.

Pugh ME, Buchowski MS, Robbins IM, Newman JH, Hemnes AR. Physical activity limitation as measured by accelerometry in pulmonary arterial hypertension. Chest. 2012 Dec; 142(6): 1391-8. PMID: 22576635, PMCID: PMC3515022, PII: chest.12-0150, DOI: 10.1378/chest.12-0150, ISSN: 1931-3543.

Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/1/2012; 186(9): 892-6. PMID: 22923661, PMCID: PMC3530218, PII: rccm.201205-0886OC, DOI: 10.1164/rccm.201205-0886OC, ISSN: 1535-4970.

Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH. Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ. 2012 Jul; 2(3): 352-8. PMID: 23130103, PMCID: PMC3487303, PII: PC-2-352, DOI: 10.4103/2045-8932.101647, ISSN: 2045-8940.

Hemnes AR, Pugh ME, Newman AL, Robbins IM, Tolle J, Austin ED, Newman JH. End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment. Chest [print-electronic]. 2011 Nov; 140(5): 1267-73. PMID: 21622547, PII: chest.11-0155, DOI: 10.1378/chest.11-0155, ISSN: 1931-3543.

Newman JH, Holt TN, Hedges LK, Womack B, Memon SS, Willers ED, Wheeler L, Phillips JA, Hamid R. High-altitude pulmonary hypertension in cattle (brisket disease): Candidate genes and gene expression profiling of peripheral blood mononuclear cells. Pulm Circ. 2011 Oct; 1(4): 462-9. PMID: 22530101, PMCID: PMC3329076, PII: PC-1-462, DOI: 10.4103/2045-8932.93545, ISSN: 2045-8940.

Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J. Heart Lung Transplant [print-electronic]. 2011 Aug; 30(8): 904-11. PMID: 21493097, PMCID: PMC3129440, PII: S1053-2498(11)00831-X, DOI: 10.1016/j.healun.2011.02.016, ISSN: 1557-3117.

King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. N. Engl. J. Med. 2011 Jul 7/21/2011; 365(3): 222-30. PMID: 21774710, PMCID: PMC3296566, DOI: 10.1056/NEJMoa1101388, ISSN: 1533-4406.

Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul; 1(3): 389-98. PMID: 22140629, PMCID: PMC3224431, PII: PC-1-389, DOI: 10.4103/2045-8932.87308, ISSN: 2045-8940.

Pasha MA, Newman JH. High-altitude disorders: pulmonary hypertension: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl): 13S-19S. PMID: 20522576, PII: 137/6_suppl/13S, DOI: 10.1378/chest.09-2445, ISSN: 1931-3543.

Hemnes AR, Newman AL, Rosenbaum B, Barrett TW, Zhou C, Rice TW, Newman JH. Bedside end-tidal CO2 tension as a screening tool to exclude pulmonary embolism. Eur. Respir. J [print-electronic]. 2010 Apr; 35(4): 735-41. PMID: 19717480, PII: 09031936.00084709, DOI: 10.1183/09031936.00084709, ISSN: 1399-3003.

Arastu MH, Vijayaraghavan J, Chissell H, Hull JB, Newman JH, Robinson JR. Early failure of a mobile-bearing unicompartmental knee replacement. Knee Surg Sports Traumatol Arthrosc [print-electronic]. 2009 Oct; 17(10): 1178-83. PMID: 19333578, DOI: 10.1007/s00167-009-0779-z, ISSN: 1433-7347.

Robbins IM, Newman JH, Johnson RF, Hemnes AR, Fremont RD, Piana RN, Zhao DX, Byrne DW. Association of the metabolic syndrome with pulmonary venous hypertension. Chest [print-electronic]. 2009 Jul; 136(1): 31-6. PMID: 19188551, PMCID: PMC2716716, PII: chest.08-2008, DOI: 10.1378/chest.08-2008, ISSN: 1931-3543.

Machado RD, Eickelberg O, Elliott CG, Geraci MW, Hanaoka M, Loyd JE, Newman JH, Phillips JA, Soubrier F, Trembath RC, Chung WK. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2009 Jun 6/30/2009; 54(1 Suppl): S32-42. PMID: 19555857, PMCID: PMC3725550, PII: S0735-1097(09)01220-0, DOI: 10.1016/j.jacc.2009.04.015, ISSN: 1558-3597.

Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M. Inflammation, growth factors, and pulmonary vascular remodeling. J. Am. Coll. Cardiol. 2009 Jun 6/30/2009; 54(1 Suppl): S10-9. PMID: 19555853, PII: S0735-1097(09)01208-X, DOI: 10.1016/j.jacc.2009.04.006, ISSN: 1558-3597.

Hamid R, Newman JH. Evidence for inflammatory signaling in idiopathic pulmonary artery hypertension: TRPC6 and nuclear factor-kappaB [editorial]. Circulation. 2009 May 5/5/2009; 119(17): 2297-8. PMID: 19414653, PII: 119/17/2297, DOI: 10.1161/CIRCULATIONAHA.109.855197, ISSN: 1524-4539.

Hamid R, Cogan JD, Hedges LK, Austin E, Phillips JA, Newman JH, Loyd JE. Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele. Hum. Mutat. 2009 Apr; 30(4): 649-54. PMID: 19206171, PMCID: PMC2663001, DOI: 10.1002/humu.20922, ISSN: 1098-1004.

Austin ED, Phillips JA, Cogan JD, Hamid R, Yu C, Stanton KC, Phillips CA, Wheeler LA, Robbins IM, Newman JH, Loyd JE. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Respir. Res. 2009; 10: 87. PMID: 19785764, PMCID: PMC2762975, PII: 1465-9921-10-87, DOI: 10.1186/1465-9921-10-87, ISSN: 1465-993X.

Phillips JA, Poling JS, Phillips CA, Stanton KC, Austin ED, Cogan JD, Wheeler L, Yu C, Newman JH, Dietz HC, Loyd JE. Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension. Genet. Med. 2008 May; 10(5): 359-65. PMID: 18496036, PII: 00125817-200805000-00010, DOI: 10.1097/GIM.0b013e318172dcdf, ISSN: 1530-0366.

Newman JH, Phillips JA, Loyd JE. Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Ann. Intern. Med. 2008 Feb 2/19/2008; 148(4): 278-83. PMID: 18283205, PII: 148/4/278, ISSN: 1539-3704.

Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Prince MA, Stanton KC, Cogan JA, Runo JR, Byrne D, Humbert M, Simonneau G, Sztrymf B, Morse JA, Knowles JA, Roberts KE, McElroy JJ, Barst RJ, Phillips JA. Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2006 Apr 4/1/2006; 173(7): 798-802. PMID: 16339917, PMCID: PMC2662954, PII: 200509-1361OC, DOI: 10.1164/rccm.200509-1361OC, ISSN: 1073-449X.

Newman JH. Pulmonary hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Nov 11/1/2005; 172(9): 1072-7. PMID: 15994464, PMCID: PMC2718396, PII: 200505-684OE, DOI: 10.1164/rccm.200505-684OE, ISSN: 1073-449X.

Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB, . Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation. 2004 Jun 6/22/2004; 109(24): 2947-52. PMID: 15210611, PII: 109/24/2947, DOI: 10.1161/01.CIR.0000132476.87231.6F, ISSN: 1524-4539.

Newman JH, Trembath RC, Morse JA, Grunig E, Loyd JE, Adnot S, Coccolo F, Ventura C, Phillips JA, Knowles JA, Janssen B, Eickelberg O, Eddahibi S, Herve P, Nichols WC, Elliott G. Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J. Am. Coll. Cardiol. 2004 Jun 6/16/2004; 43(12 Suppl S): 33S-39S. PMID: 15194176, PII: S0735109704004371, DOI: 10.1016/j.jacc.2004.02.028, ISSN: 0735-1097.

Runo JR, Vnencak-Jones CL, Prince M, Loyd JE, Wheeler L, Robbins IM, Lane KB, Newman JH, Johnson J, Nichols WC, Phillips JA. Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II. Am. J. Respir. Crit. Care Med [print-electronic]. 2003 Mar 3/15/2003; 167(6): 889-94. PMID: 12446270, PII: 200208-861OC, DOI: 10.1164/rccm.200208-861OC, ISSN: 1073-449X.

Koizumi T, Johnston D, Bjertnaes LJ, Banerjee MR, Newman JH. Inhibition of endogenous nitric oxide during endotoxemia in awake sheep - effects of Nomega-nitro-l-arginine on the distribution of pulmonary vascular resistance and prostanoid products. Exp. Lung Res. 2002 Sep; 28(6): 473-84. PMID: 12217213, DOI: 10.1080/01902140290096737, ISSN: 0190-2148.

Thomas AQ, Gaddipati R, Newman JH, Loyd JE. Genetics of primary pulmonary hypertension. Clin. Chest Med. 2001 Sep; 22(3): 477-91, ix. PMID: 11590842, ISSN: 0272-5231.

Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA, Loyd JE. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N. Engl. J. Med. 2001 Aug 8/2/2001; 345(5): 319-24. PMID: 11484688, DOI: 10.1056/NEJM200108023450502, ISSN: 0028-4793.

Koizumi T, Roselli RJ, Parker RE, Hermo-Weiler CI, Banerjee M, Newman JH. Clearance of filtered fluid from the lung during exercise: role of hyperpnea. Am. J. Respir. Crit. Care Med. 2001 Mar; 163(3 Pt 1): 614-8. PMID: 11254513, DOI: 10.1164/ajrccm.163.3.2004205, ISSN: 1073-449X.

Robbins IM, Christman BW, Newman JH, Matlock R, Loyd JE. A survey of diagnostic practices and the use of epoprostenol in patients with primary pulmonary hypertension. Chest. 1998 Nov; 114(5): 1269-75. PMID: 9824000, ISSN: 0012-3692.

Bjertnaes LJ, Koizumi T, Newman JH. Inhaled nitric oxide reduces lung fluid filtration after endotoxin in awake sheep. Am. J. Respir. Crit. Care Med. 1998 Nov; 158(5 Pt 1): 1416-23. PMID: 9817688, DOI: 10.1164/ajrccm.158.5.9607020, ISSN: 1073-449X.

Hermo-Weiler CI, Koizumi T, Parker R, Newman JH. Pulmonary vasoconstriction induced by mitral valve obstruction in sheep. J. Appl. Physiol. 1998 Nov; 85(5): 1655-60. PMID: 9804566, ISSN: 8750-7587.

Loyd JE, Slovis B, Phillips JA, Butler MG, Foroud TM, Conneally PM, Newman JH. The presence of genetic anticipation suggests that the molecular basis of familial primary pulmonary hypertension may be trinucleotide repeat expansion. Chest. 1997 Jun; 111(6 Suppl): 82S-83S. PMID: 9184540, ISSN: 0012-3692.

Newman JH. Recent trends in venous thrombosis and pulmonary embolism. Trans. Am. Clin. Climatol. Assoc. 1997; 108: 173-82; discussion 183. PMID: 9108676, PMCID: PMC2376588, ISSN: 0065-7778.

Carmichael LC, Newman JH. Lymphocytic pleural exudate in a patient receiving amiodarone. Br J Clin Pract. 1996 Jun; 50(4): 228-30. PMID: 8759573, ISSN: 0007-0947.

Koizumi T, Hermo CI, Bjertnaes LJ, Banerjee M, Newman JH, Kubo K. Nitric oxide and nitroglycerin reversal of pulmonary vasoconstriction induced by alpha-activation during exercise. Am. J. Physiol. 1996 Mar; 270(3 Pt 2): H875-80. PMID: 8780181, ISSN: 0002-9513.

Loyd JE, Butler MG, Foroud TM, Conneally PM, Phillips JA, Newman JH. Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1995 Jul; 152(1): 93-7. PMID: 7599869, DOI: 10.1164/ajrccm.152.1.7599869, ISSN: 1073-449X.

Koizumi T, Gupta R, Banerjee M, Newman JH. Changes in pulmonary vascular tone during exercise. Effects of nitric oxide (NO) synthase inhibition, L-arginine infusion, and NO inhalation. J. Clin. Invest. 1994 Dec; 94(6): 2275-82. PMID: 7527429, PMCID: PMC330054, DOI: 10.1172/JCI117590, ISSN: 0021-9738.

Kane DW, Tesauro T, Koizumi T, Gupta R, Newman JH. Exercise-induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta adrenergic receptors. J. Clin. Invest. 1994 Feb; 93(2): 677-83. PMID: 7509345, PMCID: PMC293899, DOI: 10.1172/JCI117020, ISSN: 0021-9738.

Kane DW, Tesauro T, Newman JH. Adrenergic modulation of the pulmonary circulation during strenuous exercise in sheep. Am. Rev. Respir. Dis. 1993 May; 147(5): 1233-8. PMID: 8484636, DOI: 10.1164/ajrccm/147.5.1233, ISSN: 0003-0805.

Newman JH, Cochran CP, Roselli RJ, Parker RE, King LS. Pressure and flow changes in the pulmonary circulation in exercising sheep: evidence for elevated microvascular pressure. Am. Rev. Respir. Dis. 1993 Apr; 147(4): 921-6. PMID: 8466128, DOI: 10.1164/ajrccm/147.4.921, ISSN: 0003-0805.

Kang KH, Morrow JD, Roberts LJ, Newman JH, Banerjee M. Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung. J. Appl. Physiol. 1993 Jan; 74(1): 460-5. PMID: 8444728, ISSN: 8750-7587.

Banerjee M, Kang KH, Morrow JD, Roberts LJ, Newman JH. Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ. Am. J. Physiol. 1992 Sep; 263(3 Pt 2): H660-3. PMID: 1415588, ISSN: 0002-9513.

Christman BW, McPherson CD, Newman JH, King GA, Bernard GR, Groves BM, Loyd JE. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 1992 Jul 7/9/1992; 327(2): 70-5. PMID: 1603138, DOI: 10.1056/NEJM199207093270202, ISSN: 0028-4793.

Kubo K, King LS, Kobayashi T, Newman JH. Differing effects of nitrogen mustard and hydroxyurea on lung O2 toxicity in adult sheep. Am. Rev. Respir. Dis. 1992 Jan; 145(1): 13-8. PMID: 1731575, DOI: 10.1164/ajrccm/145.1.13, ISSN: 0003-0805.

Kobayashi T, Shiki Y, Meyrick B, Burr IM, Newman JH. Simultaneous exposure of sheep to endotoxin and 100% oxygen. Am. Rev. Respir. Dis. 1991 Sep; 144(3 Pt 1): 600-5. PMID: 1892300, DOI: 10.1164/ajrccm/144.3_Pt_1.600, ISSN: 0003-0805.

Beard JT, Newman JH, Loyd JE, Byrd BF. Doppler estimation of changes in pulmonary artery pressure during hypoxic breathing. J Am Soc Echocardiogr. 1991 Mar; 4(2): 121-30. PMID: 2036224, ISSN: 0894-7317.

King LS, Fukushima M, Banerjee M, Kang KH, Newman JH, Biaggioni I. Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. Circ. Res. 1991 Feb; 68(2): 352-8. PMID: 1825033, ISSN: 0009-7330.

Fukushima M, King LS, Kang KH, Banerjee M, Newman JH. Lung mechanics and airway reactivity in sheep during development of oxygen toxicity. J. Appl. Physiol. 1990 Nov; 69(5): 1779-85. PMID: 2272971, ISSN: 8750-7587.

Biaggioni I, King LS, Enayat N, Robertson D, Newman JH. Adenosine produces pulmonary vasoconstriction in sheep. Evidence for thromboxane A2/prostaglandin endoperoxide-receptor activation. Circ. Res. 1989 Dec; 65(6): 1516-25. PMID: 2582587, ISSN: 0009-7330.

Shields GW, Sheller JR, Newman JH, Duke SS, Gillette AW, Malcom AW, Meyrick BO, Brigham KL. Airway responsiveness in isolated perfused rat lungs: effect of thoracic irradiation. Respir Physiol. 1989 Nov; 78(2): 135-44. PMID: 2609024, ISSN: 0034-5687.

Newman JH, Ross JC. Primary pulmonary hypertension: a look at the future. J. Am. Coll. Cardiol. 1989 Sep; 14(3): 551-5. PMID: 2671094, PII: 0735-1097(89)90091-0, ISSN: 0735-1097.

Duke SS, King LS, Jones MR, Newman JH, Brigham KL, Forbes JT. Human recombinant interleukin 2-activated sheep lymphocytes lyse sheep pulmonary microvascular endothelial cells. Cell. Immunol. 1989 Aug; 122(1): 188-99. PMID: 2787699, ISSN: 0008-8749.

Loyd JE, Atkinson JB, Pietra GG, Virmani R, Newman JH. Heterogeneity of pathologic lesions in familial primary pulmonary hypertension. Am. Rev. Respir. Dis. 1988 Oct; 138(4): 952-7. PMID: 3202470, DOI: 10.1164/ajrccm/138.4.952, ISSN: 0003-0805.

Wheeler AP, Jaquiss RD, Newman JH. Physician practices in the treatment of pulmonary embolism and deep venous thrombosis. Arch. Intern. Med. 1988 Jun; 148(6): 1321-5. PMID: 3377615, ISSN: 0003-9926.

Newman JH, Butka BJ, Parker RE, Roselli RJ. Effect of progressive exercise on lung fluid balance in sheep. J. Appl. Physiol. 1988 May; 64(5): 2125-31. PMID: 3391911, ISSN: 8750-7587.

Johnson MD, Newman JH, Baxter JW. Neuroleptic malignant syndrome presenting as adult respiratory distress syndrome and disseminated intravascular coagulation. South. Med. J. 1988 Apr; 81(4): 543-5. PMID: 3358184, ISSN: 0038-4348.

Newman JH. Lung vascular injury. Chest. 1988 Mar; 93(3 Suppl): 139S-146S. PMID: 2830084, ISSN: 0012-3692.

Newman JH, Wilkins JK. Fabrication of a customized cuirass for patients with severe thoracic asymmetry. Am. Rev. Respir. Dis. 1988 Jan; 137(1): 202-3. PMID: 3337464, DOI: 10.1164/ajrccm/137.1.202, ISSN: 0003-0805.