James R. Sheller, M.D.


Faculty Appointments
Professor of Medicine
M.D., Medicine , Vanderbilt University, Nashville, TennesseeM.A., Physiololgy, University of Oxford, Oxford, United KingdomB.A., University of the South, Sewanee, Tennessee
Office Address
T-1219 MCN
Vanderbilt University
Nashville, KY 2650
Research Keywords
Free radical mechanisms of allergic airway inflammation in mouse and man.
Majeski E, Hoskins A, Dworski R, Sheller JR. Iloprost inhalation in mild asthma. J Asthma [print-electronic]. 2012 Nov; 49(9): 961-5. PMID: 23033807, DOI: 10.3109/02770903.2012.724130, ISSN: 1532-4303.

Arnold DH, Gebretsadik T, Abramo TJ, Sheller JR, Resha DJ, Hartert TV. The Acute Asthma Severity Assessment Protocol (AASAP) study: objectives and methods of a study to develop an acute asthma clinical prediction rule. Emerg Med J [print-electronic]. 2012 Jun; 29(6): 444-50. PMID: 21586757, PMCID: PMC3813951, PII: emj.2010.110957, DOI: 10.1136/emj.2010.110957, ISSN: 1472-0213.

King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. N. Engl. J. Med. 2011 Jul 7/21/2011; 365(3): 222-30. PMID: 21774710, PMCID: PMC3296566, DOI: 10.1056/NEJMoa1101388, ISSN: 1533-4406.

Arnold DH, Gebretsadik T, Abramo TJ, Moons KG, Sheller JR, Hartert TV. The RAD score: a simple acute asthma severity score compares favorably to more complex scores. Ann. Allergy Asthma Immunol [print-electronic]. 2011 Jul; 107(1): 22-8. PMID: 21704881, PMCID: PMC3760486, PII: S1081-1206(11)00227-4, DOI: 10.1016/j.anai.2011.03.011, ISSN: 1534-4436.

Arnold DH, Gebretsadik T, Sheller JR, Abramo TJ, Hartert TV. Accessory muscle use in pediatric patients with acute asthma exacerbations [letter]. Ann. Allergy Asthma Immunol [print-electronic]. 2011 Apr; 106(4): 344-6. PMID: 21457886, PMCID: PMC3074618, PII: S1081-1206(11)00006-8, DOI: 10.1016/j.anai.2011.01.005, ISSN: 1534-4436.

Sheller JR, Polosukhin VV, Mitchell D, Cheng DS, Peebles RS, Blackwell TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp. Lung Res. 2009 Dec; 35(10): 883-95. PMID: 19995280, PMCID: PMC3419942, DOI: 10.3109/01902140903019710, ISSN: 1521-0499.

Moore PE, Ryckman KK, Williams SM, Patel N, Summar ML, Sheller JR. Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma. Pediatr. Pulmonol. 2009 Jul; 44(7): 649-54. PMID: 19514054, DOI: 10.1002/ppul.21033, ISSN: 1099-0496.

Rock M, Yoder S, Hoskins A, Ajayi WU, Sheller JR, Dworski R. Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma. Ann. Allergy Asthma Immunol. 2009 May; 102(5): 432-7. PMID: 19492667, ISSN: 1081-1206.

Hartert TV, Deng X, Hartman TJ, Wen W, Yang G, Gao YT, Jin M, Bai C, Gross M, Roberts LJ, Sheller JR, Christman J, Dupont W, Griffin M, Shu XO. The Shanghai Women's Asthma and Allergy Study: objectives, design, and recruitment results. Am. J. Epidemiol [print-electronic]. 2008 Jun 6/1/2008; 167(11): 1387-96. PMID: 18397914, PMCID: PMC2430736, PII: kwn057, DOI: 10.1093/aje/kwn057, ISSN: 1476-6256.

Wu P, Roberts LJ, Shintani AK, Sheller JR, Minton PA, Higgins SB, Hartert TV. Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations. Free Radic. Res. 2007 Sep; 41(9): 956-62. PMID: 17729112, PII: 781560664, DOI: 10.1080/10715760701444600, ISSN: 1071-5762.

Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, Park GY, Sheller JR, Polosukhin VV, Christman JW, Yull FE, Blackwell TS. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J. Immunol. 2007 May 5/15/2007; 178(10): 6504-13. PMID: 17475880, PII: 178/10/6504, ISSN: 0022-1767.

Talati M, Meyrick B, Peebles RS, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ, Sheller JR. Oxidant stress modulates murine allergic airway responses. Free Radic. Biol. Med [print-electronic]. 2006 Apr 4/1/2006; 40(7): 1210-9. PMID: 16545689, PII: S0891-5849(05)00710-0, DOI: 10.1016/j.freeradbiomed.2005.11.012, ISSN: 0891-5849.

Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE, McIntyre TM, Bonventre JV, Prescott SM, Roberts LJ. Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J. Biol. Chem [print-electronic]. 2006 Feb 2/24/2006; 281(8): 4616-23. PMID: 16371369, PII: M507340200, DOI: 10.1074/jbc.M507340200, ISSN: 0021-9258.

Peebles RS, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J. Immunol. 2005 Dec 12/15/2005; 175(12): 8253-9. PMID: 16339565, PII: 175/12/8253, ISSN: 0022-1767.

Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK, Dubin PJ, Sheller JR, Goleniewska K, O'Neal JF, Olson SJ, Mitchell D, Graham BS, Peebles RS. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J. Allergy Clin. Immunol. 2005 Sep; 116(3): 550-7. PMID: 16159623, PII: S0091-6749(05)01278-9, DOI: 10.1016/j.jaci.2005.03.051, ISSN: 0091-6749.

Amrol DJ, Hagaman DD, Sheller JR, Murray JJ. Soluble CD23 and interleukin-1 receptor antagonist in human asthmatics following antigen challenge. J Asthma. 2005 Feb; 42(1): 73-6. PMID: 15801332, ISSN: 0277-0903.

Hashimoto K, Sheller JR, Morrow JD, Collins RD, Goleniewska K, O'Neal J, Zhou W, Ji S, Mitchell DB, Graham BS, Peebles RS. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J. Immunol. 2005 Jan 1/1/2005; 174(1): 525-32. PMID: 15611279, PII: 174/1/525, ISSN: 0022-1767.

Aronica MA, Swaidani S, Zhang YH, Mitchell D, Mora AL, McCarthy S, O'Neal J, Topham D, Sheller JR, Boothby M. Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells. J. Allergy Clin. Immunol. 2004 Dec; 114(6): 1441-8. PMID: 15577850, PII: S0091674904022353, DOI: 10.1016/j.jaci.2004.08.025, ISSN: 0091-6749.

Aronica MA, McCarthy S, Swaidani S, Mitchell D, Goral M, Sheller JR, Boothby M. Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells. Am. J. Respir. Crit. Care Med [print-electronic]. 2004 Mar 3/1/2004; 169(5): 587-95. PMID: 14617509, PII: 200301-100OC, DOI: 10.1164/rccm.200301-100OC, ISSN: 1073-449X.

Wudel LJ, Allos TM, Washington MK, Sheller JR, Chapman WC. Multi-organ inflammation after hepatic cryoablation in BALB/c mice. J. Surg. Res. 2003 Jun 6/15/2003; 112(2): 131-7. PMID: 12888329, PII: S002248040300088X, ISSN: 0022-4804.

Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts LJ. Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2002 Dec 12/24/2002; 99(26): 16713-8. PMID: 12482927, PMCID: PMC139209, PII: 252649099, DOI: 10.1073/pnas.252649099, ISSN: 0027-8424.

Hashimoto K, Peebles RS, Sheller JR, Jarzecka K, Furlong J, Mitchell DB, Hartert TV, Graham BS. Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor. Thorax. 2002 Jun; 57(6): 524-7. PMID: 12037228, PMCID: PMC1746359, ISSN: 0040-6376.

Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD, Hashimoto Y, Christman JW, Kang KH, Jarzecka K, Furlong J, Mitchell DB, Talati M, Graham BS, Sheller JR. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 2002 Apr 4/15/2002; 165(8): 1154-60. PMID: 11956061, DOI: 10.1164/ajrccm.165.8.2106025, ISSN: 1073-449X.

Peebles RS, Hashimoto K, Collins RD, Jarzecka K, Furlong J, Mitchell DB, Sheller JR, Graham BS. Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges. J. Infect. Dis [print-electronic]. 2001 Dec 12/1/2001; 184(11): 1374-9. PMID: 11709778, PII: JID010747, DOI: 10.1086/324429, ISSN: 0022-1899.

Dworski R, Roberts LJ, Murray JJ, Morrow JD, Hartert TV, Sheller JR. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin. Exp. Allergy. 2001 Mar; 31(3): 387-90. PMID: 11260149, PII: cea1055, ISSN: 0954-7894.

Peebles RS, Sheller JR, Collins RD, Jarzecka AK, Mitchell DB, Parker RA, Graham BS. Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in mice. J. Med. Virol. 2001 Feb; 63(2): 178-88. PMID: 11170055, PII: 10.1002/1096-9071(20000201)63:2<178::AID-JMV1013>3.0.CO;2-O, ISSN: 0146-6615.

Boothby M, Mora AL, Aronica MA, Youn J, Sheller JR, Goenka S, Stephenson L. IL-4 signaling, gene transcription regulation, and the control of effector T cells. Immunol. Res. 2001; 23(2-3): 179-91. PMID: 11444383, PII: IR:23:2-3:179, DOI: 10.1385/IR:23:2-3:179, ISSN: 0257-277X.

Dworski R, Christman BW, Sheller JR. Quantitative analysis of f(2) isoprostanes. Methods Mol. Med. 2001; 56: 423-30. PMID: 21336919, DOI: 10.1385/1-59259-151-5:423, ISSN: 1543-1894.

Dworski R, Sheller JR, Christman BW. Quantitative analysis of cyclooxygenase metabolites of arachidonic Acid. Methods Mol. Med. 2001; 56: 411-22. PMID: 21336918, DOI: 10.1385/1-59259-151-5:411, ISSN: 1543-1894.

Brightling CE, Ward R, Woltmann G, Bradding P, Sheller JR, Dworski R, Pavord ID. Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am. J. Respir. Crit. Care Med. 2000 Sep; 162(3 Pt 1): 878-82. PMID: 10988099, DOI: 10.1164/ajrccm.162.3.9909064, ISSN: 1073-449X.

Peebles RS, Sheller JR, Collins RD, Jarzecka K, Mitchell DB, Graham BS. Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV. J. Infect. Dis [print-electronic]. 2000 Sep; 182(3): 671-7. PMID: 10950758, PII: JID000415, DOI: 10.1086/315783, ISSN: 0022-1899.

Peebles RS, Dworski R, Collins RD, Jarzecka K, Mitchell DB, Graham BS, Sheller JR. Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am. J. Respir. Crit. Care Med. 2000 Aug; 162(2 Pt 1): 676-81. PMID: 10934105, DOI: 10.1164/ajrccm.162.2.9911063, ISSN: 1073-449X.

Hartert TV, Dworski RT, Mellen BG, Oates JA, Murray JJ, Sheller JR. Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. Am. J. Respir. Crit. Care Med. 2000 Aug; 162(2 Pt 1): 637-40. PMID: 10934099, DOI: 10.1164/ajrccm.162.2.9904038, ISSN: 1073-449X.

Sheller JR, Mitchell D, Meyrick B, Oates J, Breyer R. EP(2) receptor mediates bronchodilation by PGE(2) in mice. J. Appl. Physiol. 2000 Jun; 88(6): 2214-8. PMID: 10846038, ISSN: 8750-7587.

Dworski R, Murray JJ, Roberts LJ, Oates JA, Morrow JD, Fisher L, Sheller JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am. J. Respir. Crit. Care Med. 1999 Dec; 160(6): 1947-51. PMID: 10588611, DOI: 10.1164/ajrccm.160.6.9903064, ISSN: 1073-449X.

Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, Boothby MR. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J. Immunol. 1999 Nov 11/1/1999; 163(9): 5116-24. PMID: 10528218, PII: ji_v163n9p5116, ISSN: 0022-1767.

Hartert TV, Wheeler AP, Sheller JR. Use of pulse oximetry to recognize severity of airflow obstruction in obstructive airway disease: correlation with pulsus paradoxus. Chest. 1999 Feb; 115(2): 475-81. PMID: 10027449, ISSN: 0012-3692.

Peebles RS, Sheller JR, Johnson JE, Mitchell DB, Graham BS. Respiratory syncytial virus infection prolongs methacholine-induced airway hyperresponsiveness in ovalbumin-sensitized mice. J. Med. Virol. 1999 Feb; 57(2): 186-92. PMID: 9892406, PII: 10.1002/(SICI)1096-9071(199902)57:2<186::AID-JMV17>3.0.CO;2-Q, ISSN: 0146-6615.

Youn J, Chen J, Goenka S, Aronica MA, Mora AL, Correa V, Sheller JR, Boothby M. In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease. J. Exp. Med. 1998 Nov 11/16/1998; 188(10): 1803-16. PMID: 9815258, PMCID: PMC2212401, ISSN: 0022-1007.

Peebles RS, Hartert TV, Sheller JR. Viral infections in asthma. Compr Ther. 1998 Oct; 24(10): 511-8. PMID: 9801850, ISSN: 0098-8243.

Aronica M, Sheller JR. Inhaled steroids in asthma. Compr Ther. 1998 Aug; 24(8): 378-82. PMID: 9740983, ISSN: 0098-8243.

Dworski R, Sheller JR. Differential sensitivities of human blood monocytes and alveolar macrophages to the inhibition of prostaglandin endoperoxide synthase-2 by interleukin-4. Prostaglandins. 1997 Apr; 53(4): 237-51. PMID: 9167211, PII: S0090698097895986, ISSN: 0090-6980.

Dworski RT, Funk CD, Oates JA, Sheller JR. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Am. J. Respir. Crit. Care Med. 1997 Jan; 155(1): 351-7. PMID: 9001335, DOI: 10.1164/ajrccm.155.1.9001335, ISSN: 1073-449X.

Lunn WW, Sheller JR. Flow volume loops in the evaluation of upper airway obstruction. Otolaryngol. Clin. North Am. 1995 Aug; 28(4): 721-9. PMID: 7478633, ISSN: 0030-6665.

Chen XS, Sheller JR, Johnson EN, Funk CD. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature. 1994 Nov 11/10/1994; 372(6502): 179-82. PMID: 7969451, DOI: 10.1038/372179a0, ISSN: 0028-0836.

Dworski R, Sheller JR. New therapies for asthma. Compr Ther. 1994; 20(11): 611-5. PMID: 7851091, ISSN: 0098-8243.

Zhou HH, Sheller JR, Nu H, Wood M, Wood AJ. Ethnic differences in response to morphine. Clin. Pharmacol. Ther. 1993 Nov; 54(5): 507-13. PMID: 8222493, ISSN: 0009-9236.

Dworski R, FitzGerald GA, Sheller JR. Thromboxane synthase inhibition in allergen challenged sheep lung: effect on eicosanoid synthesis. Eicosanoids. 1992; 5(1): 35-7. PMID: 1419078, ISSN: 0934-9820.

Sladek K, Sheller JR, FitzGerald GA, Morrow JD, Roberts LJ. Formation of PGD2 after allergen inhalation in atopic asthmatics. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21A: 433-6. PMID: 1847781, ISSN: 0732-8141.

Sheller JR. Childhood pulmonary function following hyaline membrane disease. Compr Ther. 1990 Oct; 16(10): 54-8. PMID: 2249401, ISSN: 0098-8243.

Sebaldt RJ, Sheller JR, Oates JA, Roberts LJ, FitzGerald GA. Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proc. Natl. Acad. Sci. U.S.A. 1990 Sep; 87(18): 6974-8. PMID: 2169616, PMCID: PMC54664, ISSN: 0027-8424.

Sladek K, Dworski R, Fitzgerald GA, Buitkus KL, Block FJ, Marney SR, Sheller JR. Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin. Am. Rev. Respir. Dis. 1990 Jun; 141(6): 1441-5. PMID: 2161626, DOI: 10.1164/ajrccm/141.6.1441, ISSN: 0003-0805.

Shields GW, Sheller JR, Newman JH, Duke SS, Gillette AW, Malcom AW, Meyrick BO, Brigham KL. Airway responsiveness in isolated perfused rat lungs: effect of thoracic irradiation. Respir Physiol. 1989 Nov; 78(2): 135-44. PMID: 2609024, ISSN: 0034-5687.

Lupinetti MD, Sheller JR, Catella F, Fitzgerald GA. Thromboxane biosynthesis in allergen-induced bronchospasm. Evidence for platelet activation. Am. Rev. Respir. Dis. 1989 Oct; 140(4): 932-5. PMID: 2508524, DOI: 10.1164/ajrccm/140.4.932, ISSN: 0003-0805.

Hoff SJ, Neblett WW, Heller RM, Pietsch JB, Holcomb GW, Sheller JR, Harmon TW. Postpneumonic empyema in childhood: selecting appropriate therapy. J. Pediatr. Surg. 1989 Jul; 24(7): 659-63; discussion 663. PMID: 2754582, PII: S0022346889002538, ISSN: 0022-3468.

Gald├Ęs-Sebaldt M, Sheller JR, Grogaard J, Stahlman M. Prematurity is associated with abnormal airway function in childhood. Pediatr. Pulmonol. 1989; 7(4): 259-64. PMID: 2616250, ISSN: 8755-6863.

Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ, Fitzgerald GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am. Rev. Respir. Dis. 1989 Jan; 139(1): 46-51. PMID: 2492175, DOI: 10.1164/ajrccm/139.1.46, ISSN: 0003-0805.

Sheller JR, Lucht WD, Goel AK, Snell JD, Stahlman MT. Pulmonary function in long-term survivors of hyaline membrane disease. Chest. 1988 Apr; 93(4): 734-8. PMID: 3280259, ISSN: 0012-3692.

Forman MB, Wilson BH, Sheller JR, Kopelman HA, Vaughn WK, Virmani R, Friesinger GC. Right ventricular hypertrophy is an important determinant of right ventricular infarction complicating acute inferior left ventricular infarction. J. Am. Coll. Cardiol. 1987 Dec; 10(6): 1180-7. PMID: 2960725, ISSN: 0735-1097.

Seibert K, Sheller JR, Roberts LJ. 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 189-91. PMID: 2959045, ISSN: 0732-8141.