Faculty Appointments
Research Associate Professor of Medicine
Education
Ph.D., University of Alabama, Birmingham, AlabamaB.S., University of Alabama, Birmingham, Alabama
Office Address
1030C MRB IV
Nashville, TN 37232-2279
Nashville, TN 37232-2279
Research Keywords
Helicobacter pylori
pathogenesis
Publications
Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene [print-electronic]. 2015 Jun; 34(26): 3429-40. PMID: 25174398, PMCID: PMC4345146, PII: onc2014273, DOI: 10.1038/onc.2014.273, ISSN: 1476-5594.
Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene [print-electronic]. 2015 Jun; 34(26): 3429-40. PMID: 25174398, PMCID: PMC4345146, PII: onc2014273, DOI: 10.1038/onc.2014.273, ISSN: 1476-5594.
Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288.
Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288.
Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287.
Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287.
Sitaraman R, Israel DA, Romero-Gallo J, Peek RM. Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties. J. Clin. Microbiol [print-electronic]. 2012 Mar; 50(3): 1014-8. PMID: 22205825, PMCID: PMC3295145, PII: JCM.05252-11, DOI: 10.1128/JCM.05252-11, ISSN: 1098-660X.
Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): G504-14. PMID: 22173918, PMCID: PMC3311435, PII: ajpgi.00312.2011, DOI: 10.1152/ajpgi.00312.2011, ISSN: 1522-1547.
Takeuchi H, Zhang YN, Israel DA, Peek RM, Kamioka M, Yanai H, Morimoto N, Sugiura T. Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation. World J. Gastroenterol. 2012 Feb 2/7/2012; 18(5): 425-34. PMID: 22346248, PMCID: PMC3270507, DOI: 10.3748/wjg.v18.i5.425, ISSN: 2219-2840.
Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology [print-electronic]. 2011 Nov; 141(5): 1696-708.e1. PMID: 21839041, PMCID: PMC3202654, PII: S0016-5085(11)01080-8, DOI: 10.1053/j.gastro.2011.07.045, ISSN: 1528-0012.
de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut [print-electronic]. 2011 Sep; 60(9): 1189-95. PMID: 21357593, PMCID: PMC3133872, PII: gut.2010.234468, DOI: 10.1136/gut.2010.234468, ISSN: 1468-3288.
Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM. ß-Catenin and p120 mediate PPARd-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology [print-electronic]. 2011 Aug; 141(2): 553-64. PMID: 21704622, PMCID: PMC3152603, PII: S0016-5085(11)00621-4, DOI: 10.1053/j.gastro.2011.05.004, ISSN: 1528-0012.
Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM. Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am. J. Pathol [print-electronic]. 2011 Apr; 178(4): 1448-52. PMID: 21406172, PMCID: PMC3078468, PII: S0002-9440(10)00281-6, DOI: 10.1016/j.ajpath.2010.12.018, ISSN: 1525-2191.
Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445.
Franco AT, Friedman DB, Nagy TA, Romero-Gallo J, Krishna U, Kendall A, Israel DA, Tegtmeyer N, Washington MK, Peek RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol. Cell Proteomics [print-electronic]. 2009 Aug; 8(8): 1947-58. PMID: 19470446, PMCID: PMC2722763, PII: M900139-MCP200, DOI: 10.1074/mcp.M900139-MCP200, ISSN: 1535-9484.
Schneider N, Krishna U, Romero-Gallo J, Israel DA, Piazuelo MB, Camargo MC, Sicinschi LA, Schneider BG, Correa P, Peek RM. Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential. J. Infect. Dis. 2009 Apr 4/15/2009; 199(8): 1218-21. PMID: 19278338, PMCID: PMC2828761, DOI: 10.1086/597416, ISSN: 0022-1899.
Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J. Infect. Dis. 2009 Mar 3/1/2009; 199(5): 641-51. PMID: 19199544, PMCID: PMC2830010, PII: 10.1086/596660, DOI: 10.1086/596660, ISSN: 0022-1899.
McClain MS, Shaffer CL, Israel DA, Peek RM, Cover TL. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics. 2009; 10: 3. PMID: 19123947, PMCID: PMC2627912, PII: 1471-2164-10-3, DOI: 10.1186/1471-2164-10-3, ISSN: 1471-2164.
Gaus K, Huang Y, Israel DA, Pendland SL, Adeniyi BA, Mahady GB. Standardized ginger (Zingiber officinale) extract reduces bacterial load and suppresses acute and chronic inflammation in Mongolian gerbils infected with cagAHelicobacter pylori. Pharm Biol. 2009; 47(1): 92-8. PMID: 20376296, PMCID: PMC2849670, DOI: 10.1080/13880200802448690, ISSN: 1744-5116.
Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology [print-electronic]. 2009 Jan; 136(1): 236-46. PMID: 18996125, PMCID: PMC2678540, PII: S0016-5085(08)01804-0, DOI: 10.1053/j.gastro.2008.10.011, ISSN: 1528-0012.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM. P120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol. Biol. Cell [print-electronic]. 2008 Oct; 19(10): 4110-21. PMID: 18653469, PMCID: PMC2555941, PII: E08-03-0283, DOI: 10.1091/mbc.E08-03-0283, ISSN: 1939-4586.
O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J. Biol. Chem [print-electronic]. 2008 Aug 8/29/2008; 283(35): 23922-30. PMID: 18579524, PMCID: PMC2527108, PII: M801144200, DOI: 10.1074/jbc.M801144200, ISSN: 0021-9258.
Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM. Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res. 2008 Jan 1/15/2008; 68(2): 379-87. PMID: 18199531, PMCID: PMC3114460, PII: 68/2/379, DOI: 10.1158/0008-5472.CAN-07-0824, ISSN: 1538-7445.
O'Brien DP, Israel DA, Krishna U, Romero-Gallo J, Nedrud J, Medof ME, Lin F, Redline R, Lublin DM, Nowicki BJ, Franco AT, Ogden S, Williams AD, Polk DB, Peek RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J. Biol. Chem [print-electronic]. 2006 May 5/12/2006; 281(19): 13317-23. PMID: 16543227, PII: M601805200, DOI: 10.1074/jbc.M601805200, ISSN: 0021-9258.
Israel DA, Peek RM. The role of persistence in Helicobacter pylori pathogenesis. Curr. Opin. Gastroenterol. 2006 Jan; 22(1): 3-7. PMID: 16319669, PII: 00001574-200601000-00003, ISSN: 0267-1379.
Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O'Brien DP, Romero-Gallo J, Peek RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Jul 7/26/2005; 102(30): 10646-51. PMID: 16027366, PMCID: PMC1180811, PII: 0504927102, DOI: 10.1073/pnas.0504927102, ISSN: 0027-8424.
Popescu A, Karpay A, Israel DA, Peek RM, Krezel AM. Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators. Proteins. 2005 May 5/1/2005; 59(2): 303-11. PMID: 15723352, DOI: 10.1002/prot.20406, ISSN: 1097-0134.
Minami M, Ando T, Hashikawa SN, Torii K, Hasegawa T, Israel DA, Ina K, Kusugami K, Goto H, Ohta M. Effect of glycine on Helicobacter pylori in vitro. Antimicrob. Agents Chemother. 2004 Oct; 48(10): 3782-8. PMID: 15388434, PMCID: PMC521915, PII: 48/10/3782, DOI: 10.1128/AAC.48.10.3782-3788.2004, ISSN: 0066-4804.
Gewirtz AT, Yu Y, Krishna US, Israel DA, Lyons SL, Peek RM. Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J. Infect. Dis [print-electronic]. 2004 May 5/15/2004; 189(10): 1914-20. PMID: 15122529, PII: JID31638, DOI: 10.1086/386289, ISSN: 0022-1899.
Crawford HC, Krishna US, Israel DA, Matrisian LM, Washington MK, Peek RM. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology. 2003 Oct; 125(4): 1125-36. PMID: 14517796, PII: S001650850301206X, ISSN: 0016-5085.
Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, Dangler CA, Israel DA, Krishna U, Gaus K, Peek RM. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology. 2003 Jun; 124(7): 1879-90. PMID: 12806621, PII: S0016508503004062, ISSN: 0016-5085.
Cover TL, Krishna US, Israel DA, Peek RM. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res. 2003 Mar 3/1/2003; 63(5): 951-7. PMID: 12615708, ISSN: 0008-5472.
Takeuchi H, Israel DA, Miller GG, Donahue JP, Krishna U, Gaus K, Peek RM. Characterization of expression of a functionally conserved Helicobacter pylori methyltransferase-encoding gene within inflamed mucosa and during in vitro growth. J. Infect. Dis [print-electronic]. 2002 Oct 10/15/2002; 186(8): 1186-9. PMID: 12355374, PII: JID020491, DOI: 10.1086/343810, ISSN: 0022-1899.
Donahue JP, Israel DA, Torres VJ, Necheva AS, Miller GG. Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherence. FEMS Microbiol. Lett. 2002 Mar 3/5/2002; 208(2): 295-301. PMID: 11959452, PII: S0378109702004792, ISSN: 0378-1097.
Israel DA, Salama N, Krishna U, Rieger UM, Atherton JC, Falkow S, Peek RM. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Dec 12/4/2001; 98(25): 14625-30. PMID: 11724955, PMCID: PMC64732, PII: 251551698, DOI: 10.1073/pnas.251551698, ISSN: 0027-8424.
Kidd M, Peek RM, Lastovica AJ, Israel DA, Kummer AF, Louw JA. Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Gut. 2001 Nov; 49(5): 629-35. PMID: 11600464, PMCID: PMC1728508, ISSN: 0017-5749.
Israel DA, Peek RM. Pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment. Pharmacol. Ther. 2001 Sep; 15(9): 1271-90. PMID: 11552897, PII: apt1052, ISSN: 0269-2813.
Gupta RA, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, Peek RM. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J. Biol. Chem [print-electronic]. 2001 Aug 8/17/2001; 276(33): 31059-66. PMID: 11397815, PII: M104141200, DOI: 10.1074/jbc.M104141200, ISSN: 0021-9258.
Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, Tham KT, Camorlinga M, Blaser MJ, Falkow S, Peek RM. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest. 2001 Mar; 107(5): 611-20. PMID: 11238562, PMCID: PMC199426, DOI: 10.1172/JCI11450, ISSN: 0021-9738.
Pérez-Pérez GI, Israel DA. Role of iron in Helicobacter pylori: its influence in outer membrane protein expression and in pathogenicity. Eur J Gastroenterol Hepatol. 2000 Dec; 12(12): 1263-5. PMID: 11192313, ISSN: 0954-691X.
Donahue JP, Israel DA, Peek RM, Blaser MJ, Miller GG. Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori. Mol. Microbiol. 2000 Sep; 37(5): 1066-74. PMID: 10972825, PII: mmi2036, ISSN: 0950-382X.
Ando T, Xu Q, Torres M, Kusugami K, Israel DA, Blaser MJ. Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer. Mol. Microbiol. 2000 Sep; 37(5): 1052-65. PMID: 10972824, PII: mmi2049, ISSN: 0950-382X.
Israel DA, Lou AS, Blaser MJ. Characteristics of Helicobacter pylori natural transformation. FEMS Microbiol. Lett. 2000 May 5/15/2000; 186(2): 275-80. PMID: 10802184, PII: S0378-1097(00)00156-7, ISSN: 0378-1097.
Kuipers EJ, Israel DA, Kusters JG, Gerrits MM, Weel J, van Der Ende A, van Der Hulst RW, Wirth HP, Höök-Nikanne J, Thompson SA, Blaser MJ. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host. J. Infect. Dis. 2000 Jan; 181(1): 273-82. PMID: 10608776, PMCID: PMC2766531, PII: JID990318, DOI: 10.1086/315173, ISSN: 0022-1899.
Ando T, Israel DA, Kusugami K, Blaser MJ. HP0333, a member of the dprA family, is involved in natural transformation in Helicobacter pylori. J. Bacteriol. 1999 Sep; 181(18): 5572-80. PMID: 10482496, PMCID: PMC94075, ISSN: 0021-9193.
Kuipers EJ, Israel DA, Kusters JG, Blaser MJ. Evidence for a conjugation-like mechanism of DNA transfer in Helicobacter pylori. J. Bacteriol. 1998 Jun; 180(11): 2901-5. PMID: 9603879, PMCID: PMC107256, ISSN: 0021-9193.
Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene [print-electronic]. 2015 Jun; 34(26): 3429-40. PMID: 25174398, PMCID: PMC4345146, PII: onc2014273, DOI: 10.1038/onc.2014.273, ISSN: 1476-5594.
Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288.
Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut [print-electronic]. 2015 May; 64(5): 720-30. PMID: 25123931, PMCID: PMC4329117, PII: gutjnl-2014-307650, DOI: 10.1136/gutjnl-2014-307650, ISSN: 1468-3288.
Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287.
Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Genome Announc. 2015; 3(3): PMID: 26067974, PMCID: PMC4463538, PII: 3/3/e00641-15, DOI: 10.1128/genomeA.00641-15, ISSN: 2169-8287.
Sitaraman R, Israel DA, Romero-Gallo J, Peek RM. Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties. J. Clin. Microbiol [print-electronic]. 2012 Mar; 50(3): 1014-8. PMID: 22205825, PMCID: PMC3295145, PII: JCM.05252-11, DOI: 10.1128/JCM.05252-11, ISSN: 1098-660X.
Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): G504-14. PMID: 22173918, PMCID: PMC3311435, PII: ajpgi.00312.2011, DOI: 10.1152/ajpgi.00312.2011, ISSN: 1522-1547.
Takeuchi H, Zhang YN, Israel DA, Peek RM, Kamioka M, Yanai H, Morimoto N, Sugiura T. Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation. World J. Gastroenterol. 2012 Feb 2/7/2012; 18(5): 425-34. PMID: 22346248, PMCID: PMC3270507, DOI: 10.3748/wjg.v18.i5.425, ISSN: 2219-2840.
Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology [print-electronic]. 2011 Nov; 141(5): 1696-708.e1. PMID: 21839041, PMCID: PMC3202654, PII: S0016-5085(11)01080-8, DOI: 10.1053/j.gastro.2011.07.045, ISSN: 1528-0012.
de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut [print-electronic]. 2011 Sep; 60(9): 1189-95. PMID: 21357593, PMCID: PMC3133872, PII: gut.2010.234468, DOI: 10.1136/gut.2010.234468, ISSN: 1468-3288.
Nagy TA, Wroblewski LE, Wang D, Piazuelo MB, Delgado A, Romero-Gallo J, Noto J, Israel DA, Ogden SR, Correa P, Cover TL, Peek RM. ß-Catenin and p120 mediate PPARd-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology [print-electronic]. 2011 Aug; 141(2): 553-64. PMID: 21704622, PMCID: PMC3152603, PII: S0016-5085(11)00621-4, DOI: 10.1053/j.gastro.2011.05.004, ISSN: 1528-0012.
Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, Slaughter JC, Perez-Perez G, Israel DA, Peek RM. Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am. J. Pathol [print-electronic]. 2011 Apr; 178(4): 1448-52. PMID: 21406172, PMCID: PMC3078468, PII: S0002-9440(10)00281-6, DOI: 10.1016/j.ajpath.2010.12.018, ISSN: 1525-2191.
Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445.
Franco AT, Friedman DB, Nagy TA, Romero-Gallo J, Krishna U, Kendall A, Israel DA, Tegtmeyer N, Washington MK, Peek RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol. Cell Proteomics [print-electronic]. 2009 Aug; 8(8): 1947-58. PMID: 19470446, PMCID: PMC2722763, PII: M900139-MCP200, DOI: 10.1074/mcp.M900139-MCP200, ISSN: 1535-9484.
Schneider N, Krishna U, Romero-Gallo J, Israel DA, Piazuelo MB, Camargo MC, Sicinschi LA, Schneider BG, Correa P, Peek RM. Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential. J. Infect. Dis. 2009 Apr 4/15/2009; 199(8): 1218-21. PMID: 19278338, PMCID: PMC2828761, DOI: 10.1086/597416, ISSN: 0022-1899.
Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J. Infect. Dis. 2009 Mar 3/1/2009; 199(5): 641-51. PMID: 19199544, PMCID: PMC2830010, PII: 10.1086/596660, DOI: 10.1086/596660, ISSN: 0022-1899.
McClain MS, Shaffer CL, Israel DA, Peek RM, Cover TL. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics. 2009; 10: 3. PMID: 19123947, PMCID: PMC2627912, PII: 1471-2164-10-3, DOI: 10.1186/1471-2164-10-3, ISSN: 1471-2164.
Gaus K, Huang Y, Israel DA, Pendland SL, Adeniyi BA, Mahady GB. Standardized ginger (Zingiber officinale) extract reduces bacterial load and suppresses acute and chronic inflammation in Mongolian gerbils infected with cagAHelicobacter pylori. Pharm Biol. 2009; 47(1): 92-8. PMID: 20376296, PMCID: PMC2849670, DOI: 10.1080/13880200802448690, ISSN: 1744-5116.
Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology [print-electronic]. 2009 Jan; 136(1): 236-46. PMID: 18996125, PMCID: PMC2678540, PII: S0016-5085(08)01804-0, DOI: 10.1053/j.gastro.2008.10.011, ISSN: 1528-0012.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM. P120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol. Biol. Cell [print-electronic]. 2008 Oct; 19(10): 4110-21. PMID: 18653469, PMCID: PMC2555941, PII: E08-03-0283, DOI: 10.1091/mbc.E08-03-0283, ISSN: 1939-4586.
O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J. Biol. Chem [print-electronic]. 2008 Aug 8/29/2008; 283(35): 23922-30. PMID: 18579524, PMCID: PMC2527108, PII: M801144200, DOI: 10.1074/jbc.M801144200, ISSN: 0021-9258.
Franco AT, Johnston E, Krishna U, Yamaoka Y, Israel DA, Nagy TA, Wroblewski LE, Piazuelo MB, Correa P, Peek RM. Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res. 2008 Jan 1/15/2008; 68(2): 379-87. PMID: 18199531, PMCID: PMC3114460, PII: 68/2/379, DOI: 10.1158/0008-5472.CAN-07-0824, ISSN: 1538-7445.
O'Brien DP, Israel DA, Krishna U, Romero-Gallo J, Nedrud J, Medof ME, Lin F, Redline R, Lublin DM, Nowicki BJ, Franco AT, Ogden S, Williams AD, Polk DB, Peek RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J. Biol. Chem [print-electronic]. 2006 May 5/12/2006; 281(19): 13317-23. PMID: 16543227, PII: M601805200, DOI: 10.1074/jbc.M601805200, ISSN: 0021-9258.
Israel DA, Peek RM. The role of persistence in Helicobacter pylori pathogenesis. Curr. Opin. Gastroenterol. 2006 Jan; 22(1): 3-7. PMID: 16319669, PII: 00001574-200601000-00003, ISSN: 0267-1379.
Franco AT, Israel DA, Washington MK, Krishna U, Fox JG, Rogers AB, Neish AS, Collier-Hyams L, Perez-Perez GI, Hatakeyama M, Whitehead R, Gaus K, O'Brien DP, Romero-Gallo J, Peek RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Jul 7/26/2005; 102(30): 10646-51. PMID: 16027366, PMCID: PMC1180811, PII: 0504927102, DOI: 10.1073/pnas.0504927102, ISSN: 0027-8424.
Popescu A, Karpay A, Israel DA, Peek RM, Krezel AM. Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators. Proteins. 2005 May 5/1/2005; 59(2): 303-11. PMID: 15723352, DOI: 10.1002/prot.20406, ISSN: 1097-0134.
Minami M, Ando T, Hashikawa SN, Torii K, Hasegawa T, Israel DA, Ina K, Kusugami K, Goto H, Ohta M. Effect of glycine on Helicobacter pylori in vitro. Antimicrob. Agents Chemother. 2004 Oct; 48(10): 3782-8. PMID: 15388434, PMCID: PMC521915, PII: 48/10/3782, DOI: 10.1128/AAC.48.10.3782-3788.2004, ISSN: 0066-4804.
Gewirtz AT, Yu Y, Krishna US, Israel DA, Lyons SL, Peek RM. Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity. J. Infect. Dis [print-electronic]. 2004 May 5/15/2004; 189(10): 1914-20. PMID: 15122529, PII: JID31638, DOI: 10.1086/386289, ISSN: 0022-1899.
Crawford HC, Krishna US, Israel DA, Matrisian LM, Washington MK, Peek RM. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology. 2003 Oct; 125(4): 1125-36. PMID: 14517796, PII: S001650850301206X, ISSN: 0016-5085.
Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, Dangler CA, Israel DA, Krishna U, Gaus K, Peek RM. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology. 2003 Jun; 124(7): 1879-90. PMID: 12806621, PII: S0016508503004062, ISSN: 0016-5085.
Cover TL, Krishna US, Israel DA, Peek RM. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res. 2003 Mar 3/1/2003; 63(5): 951-7. PMID: 12615708, ISSN: 0008-5472.
Takeuchi H, Israel DA, Miller GG, Donahue JP, Krishna U, Gaus K, Peek RM. Characterization of expression of a functionally conserved Helicobacter pylori methyltransferase-encoding gene within inflamed mucosa and during in vitro growth. J. Infect. Dis [print-electronic]. 2002 Oct 10/15/2002; 186(8): 1186-9. PMID: 12355374, PII: JID020491, DOI: 10.1086/343810, ISSN: 0022-1899.
Donahue JP, Israel DA, Torres VJ, Necheva AS, Miller GG. Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherence. FEMS Microbiol. Lett. 2002 Mar 3/5/2002; 208(2): 295-301. PMID: 11959452, PII: S0378109702004792, ISSN: 0378-1097.
Israel DA, Salama N, Krishna U, Rieger UM, Atherton JC, Falkow S, Peek RM. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Dec 12/4/2001; 98(25): 14625-30. PMID: 11724955, PMCID: PMC64732, PII: 251551698, DOI: 10.1073/pnas.251551698, ISSN: 0027-8424.
Kidd M, Peek RM, Lastovica AJ, Israel DA, Kummer AF, Louw JA. Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Gut. 2001 Nov; 49(5): 629-35. PMID: 11600464, PMCID: PMC1728508, ISSN: 0017-5749.
Israel DA, Peek RM. Pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment. Pharmacol. Ther. 2001 Sep; 15(9): 1271-90. PMID: 11552897, PII: apt1052, ISSN: 0269-2813.
Gupta RA, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, Peek RM. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J. Biol. Chem [print-electronic]. 2001 Aug 8/17/2001; 276(33): 31059-66. PMID: 11397815, PII: M104141200, DOI: 10.1074/jbc.M104141200, ISSN: 0021-9258.
Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, Tham KT, Camorlinga M, Blaser MJ, Falkow S, Peek RM. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J. Clin. Invest. 2001 Mar; 107(5): 611-20. PMID: 11238562, PMCID: PMC199426, DOI: 10.1172/JCI11450, ISSN: 0021-9738.
Pérez-Pérez GI, Israel DA. Role of iron in Helicobacter pylori: its influence in outer membrane protein expression and in pathogenicity. Eur J Gastroenterol Hepatol. 2000 Dec; 12(12): 1263-5. PMID: 11192313, ISSN: 0954-691X.
Donahue JP, Israel DA, Peek RM, Blaser MJ, Miller GG. Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori. Mol. Microbiol. 2000 Sep; 37(5): 1066-74. PMID: 10972825, PII: mmi2036, ISSN: 0950-382X.
Ando T, Xu Q, Torres M, Kusugami K, Israel DA, Blaser MJ. Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer. Mol. Microbiol. 2000 Sep; 37(5): 1052-65. PMID: 10972824, PII: mmi2049, ISSN: 0950-382X.
Israel DA, Lou AS, Blaser MJ. Characteristics of Helicobacter pylori natural transformation. FEMS Microbiol. Lett. 2000 May 5/15/2000; 186(2): 275-80. PMID: 10802184, PII: S0378-1097(00)00156-7, ISSN: 0378-1097.
Kuipers EJ, Israel DA, Kusters JG, Gerrits MM, Weel J, van Der Ende A, van Der Hulst RW, Wirth HP, Höök-Nikanne J, Thompson SA, Blaser MJ. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host. J. Infect. Dis. 2000 Jan; 181(1): 273-82. PMID: 10608776, PMCID: PMC2766531, PII: JID990318, DOI: 10.1086/315173, ISSN: 0022-1899.
Ando T, Israel DA, Kusugami K, Blaser MJ. HP0333, a member of the dprA family, is involved in natural transformation in Helicobacter pylori. J. Bacteriol. 1999 Sep; 181(18): 5572-80. PMID: 10482496, PMCID: PMC94075, ISSN: 0021-9193.
Kuipers EJ, Israel DA, Kusters JG, Blaser MJ. Evidence for a conjugation-like mechanism of DNA transfer in Helicobacter pylori. J. Bacteriol. 1998 Jun; 180(11): 2901-5. PMID: 9603879, PMCID: PMC107256, ISSN: 0021-9193.