Yan Ru Su, M.D.

Research Associate Professor

yan.ru.su@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Medicine
Education
M.Sc., Cardiovascular Pathophysiology, Nanjing Medical College, Nanjing, ChinaM.D., Medicine, Wannan Medical College, Wuhu, China
Office Address
322 PRB
2220 Pierce Ave
Nashville, TN 6300
Publications
Miao J, Huang S, Su YR, Lenneman CA, Wright M, Harrell FE, Sawyer DB, Lenihan DJ. Effects of Endogenous Serum Neuregulin-1ß on Morbidity and Mortality in Patients with Heart Failure and Left Ventricular Systolic Dysfunction. Biomarkers [print-electronic]. 2018 Jun 6/6/2018; 1-18. PMID: 29871526, DOI: 10.1080/1354750X.2018.1485054, ISSN: 1366-5804.

Absi TS, Galindo CL, Gumina RJ, Atkinson J, Guo Y, Tomasek K, Sawyer DB, Byrne JG, Kaiser CA, Shah AS, Su YR, Petracek M. Altered ADAMTS5 Expression and Versican Proteolysis: A Possible Molecular Mechanism in Barlow's Disease. Ann. Thorac. Surg [print-electronic]. 2018 Apr; 105(4): 1144-51. PMID: 29248417, PII: S0003-4975(17)31611-9, DOI: 10.1016/j.athoracsur.2017.11.035, ISSN: 1552-6259.

Bachmann KN, Deger SM, Alsouqi A, Huang S, Xu M, Ferguson JF, Su YR, Niswender KD, Ikizler TA, Wang TJ. Acute effects of insulin on circulating natriuretic peptide levels in humans. PLoS ONE. 2018; 13(5): e0196869. PMID: 29758041, PMCID: PMC5951576, PII: PONE-D-17-42749, DOI: 10.1371/journal.pone.0196869, ISSN: 1932-6203.

Meoli DF, Su YR, Brittain EL, Robbins IM, Hemnes AR, Monahan K. The transpulmonary ratio of endothelin 1 is elevated in patients with preserved left ventricular ejection fraction and combined pre- and post-capillary pulmonary hypertension. Pulm Circ [print-electronic]. 2018 Jan; 8(1): 2045893217745019. PMID: 29251543, PMCID: PMC5764145, DOI: 10.1177/2045893217745019, ISSN: 2045-8932.

Durbin MD, Cadar AG, Williams CH, Guo Y, Bichell DP, Su YR, Hong CC. Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. Pediatr Cardiol [print-electronic]. 2017 Aug; 38(6): 1232-40. PMID: 28608148, PMCID: PMC5577922, PII: 10.1007/s00246-017-1650-5, DOI: 10.1007/s00246-017-1650-5, ISSN: 1432-1971.

Angel PM, Baldwin HS, Gottlieb Sen D, Su YR, Mayer JE, Bichell D, Drake RR. Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve. Biochim. Biophys. Acta [print-electronic]. 2017 Jul; 1865(7): 927-35. PMID: 28341601, PMCID: PMC5527275, PII: S1570-9639(17)30051-1, DOI: 10.1016/j.bbapap.2017.03.009, ISSN: 0006-3002.

Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM. Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenet. Genomics. 2017 Jul; 27(7): 247-54. PMID: 28542097, PMCID: PMC5502740, DOI: 10.1097/FPC.0000000000000284, ISSN: 1744-6880.

Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE, Su YR, Absi T, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS, Gumina RJ. Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy. Circ Heart Fail. 2017 Feb; 10(2): PMID: 28209764, PMCID: PMC5319711, PII: CIRCHEARTFAILURE.116.003523, DOI: 10.1161/CIRCHEARTFAILURE.116.003523, ISSN: 1941-3297.

Swiger KJ, Friedman EA, Brittain EL, Tomasek KA, Huang S, Su YR, Sawyer DB, Lenihan DJ. Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis. Amyloid [print-electronic]. 2016 Dec; 23(4): 242-8. PMID: 27809600, DOI: 10.1080/13506129.2016.1242480, ISSN: 1744-2818.

Jefferson AL, Gifford KA, Acosta LM, Bell SP, Donahue MJ, Davis LT, Gottlieb J, Gupta DK, Hohman TJ, Lane EM, Libon DJ, Mendes LA, Niswender K, Pechman KR, Rane S, Ruberg FL, Su YR, Zetterberg H, Liu D. The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. J. Alzheimers Dis. 2016 Mar 3/8/2016; 52(2): 539-59. PMID: 26967211, PMCID: PMC4866875, PII: JAD150914, DOI: 10.3233/JAD-150914, ISSN: 1875-8908.

Rath R, Lee JB, Tran TL, Lenihan SF, Galindo CL, Su YR, Absi T, Bellan LM, Sawyer DB, Sung HJ. Biomimetic microstructure morphology in electrospun fiber mats is critical for maintaining healthy cardiomyocyte phenotype. Cell Mol Bioeng [print-electronic]. 2016 Mar; 9(1): 107-15. PMID: 28042345, PMCID: PMC5193097, DOI: 10.1007/s12195-015-0412-9, ISSN: 1865-5025.

Zhang H, Thoonen R, Yao V, Buys ES, Popovich J, Su YR, Wang TJ, Scherrer-Crosbie M. Regulation of B-type natriuretic peptide synthesis by insulin in obesity in male mice. Exp. Physiol [print-electronic]. 2016 Jan; 101(1): 113-23. PMID: 26446173, DOI: 10.1113/EP085091, ISSN: 1469-445X.

Su YR, Chiusa M, Brittain E, Hemnes AR, Absi TS, Lim CC, Di Salvo TG. Right ventricular protein expression profile in end-stage heart failure. Pulm Circ. 2015 Sep; 5(3): 481-97. PMID: 26401249, PMCID: PMC4556499, PII: PC2013184, DOI: 10.1086/682219, ISSN: 2045-8932.

Di Salvo TG, Guo Y, Su YR, Clark T, Brittain E, Absi T, Maltais S, Hemnes A. Right ventricular long noncoding RNA expression in human heart failure. Pulm Circ. 2015 Mar; 5(1): 135-61. PMID: 25992278, PMCID: PMC4405709, PII: PC2013114, DOI: 10.1086/679721, ISSN: 2045-8932.

Tavori H, Su YR, Yancey PG, Giunzioni I, Wilhelm AJ, Blakemore JL, Zabalawi M, Linton MF, Sorci-Thomas MG, Fazio S. Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL. J. Lipid Res [print-electronic]. 2015 Mar; 56(3): 635-43. PMID: 25593328, PMCID: PMC4340310, PII: jlr.M056408, DOI: 10.1194/jlr.M056408, ISSN: 1539-7262.

Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy. Circ Cardiovasc Genet [print-electronic]. 2013 Aug; 6(4): 317-26. PMID: 23861363, PMCID: PMC3895490, PII: CIRCGENETICS.113.000011, DOI: 10.1161/CIRCGENETICS.113.000011, ISSN: 1942-3268.

Monahan K, Scott TA, Su YR, Lenneman CG, Zhao DX, Robbins IM, Hemnes AR. Reproducibility of intracardiac and transpulmonary biomarkers in the evaluation of pulmonary hypertension. Pulm Circ. 2013 Apr; 3(2): 345-9. PMID: 24015334, PMCID: PMC3757828, PII: PC-3-345, DOI: 10.4103/2045-8932.114762, ISSN: 2045-8932.

Hutcheson JD, Chen J, Sewell-Loftin MK, Ryzhova LM, Fisher CI, Su YR, Merryman WD. Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2013 Jan; 33(1): 114-20. PMID: 23162011, PMCID: PMC3536033, PII: ATVBAHA.112.300278, DOI: 10.1161/ATVBAHA.112.300278, ISSN: 1524-4636.

Jayagopal A, Su YR, Blakemore JL, Linton MF, Fazio S, Haselton FR. Quantum dot mediated imaging of atherosclerosis. Nanotechnology [print-electronic]. 2009 Apr 4/22/2009; 20(16): 165102. PMID: 19420562, PMCID: PMC2718756, PII: S0957-4484(09)04835-1, DOI: 10.1088/0957-4484/20/16/165102, ISSN: 1361-6528.

Su YR, Blakemore JL, Zhang Y, Linton MF, Fazio S. Lentiviral transduction of apoAI into hematopoietic progenitor cells and macrophages: applications to cell therapy of atherosclerosis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2008 Aug; 28(8): 1439-46. PMID: 18497309, PMCID: PMC2744493, PII: ATVBAHA.107.160093, DOI: 10.1161/ATVBAHA.107.160093, ISSN: 1524-4636.

Dove DE, Su YR, Swift LL, Linton MF, Fazio S. ACAT1 deficiency increases cholesterol synthesis in mouse peritoneal macrophages. Atherosclerosis [print-electronic]. 2006 Jun; 186(2): 267-74. PMID: 16144700, PII: S0021-9150(05)00516-2, DOI: 10.1016/j.atherosclerosis.2005.08.005, ISSN: 0021-9150.

Braun NA, Mohler PJ, Weisgraber KH, Hasty AH, Linton MF, Yancey PG, Su YR, Fazio S, Swift LL. Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. J. Lipid Res [print-electronic]. 2006 Jun; 47(6): 1176-86. PMID: 16534141, PII: M500503-JLR200, DOI: 10.1194/jlr.M500503-JLR200, ISSN: 0022-2275.

Su YR, Dove DE, Major AS, Hasty AH, Boone B, Linton MF, Fazio S. Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation [print-electronic]. 2005 May 5/10/2005; 111(18): 2373-81. PMID: 15851589, PII: 01.CIR.0000164236.19860.13, DOI: 10.1161/01.CIR.0000164236.19860.13, ISSN: 1524-4539.

Dove DE, Su YR, Zhang W, Jerome WG, Swift LL, Linton MF, Fazio S. ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Jan; 25(1): 128-34. PMID: 15499044, PII: 01.ATV.0000148323.94021.e5, DOI: 10.1161/01.ATV.0000148323.94021.e5, ISSN: 1524-4636.

Zhang W, Yancey PG, Su YR, Babaev VR, Zhang Y, Fazio S, Linton MF. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation [print-electronic]. 2003 Nov 11/4/2003; 108(18): 2258-63. PMID: 14581413, PII: 01.CIR.0000093189.97429.9D, DOI: 10.1161/01.CIR.0000093189.97429.9D, ISSN: 1524-4539.

Su YR, Ishiguro H, Major AS, Dove DE, Zhang W, Hasty AH, Babaev VR, Linton MF, Fazio S. Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters. Mol. Ther. 2003 Oct; 8(4): 576-83. PMID: 14529830, PII: S1525001603002144, ISSN: 1525-0016.

Su YR, Linton MF, Fazio S. Rapid quantification of murine ABC mRNAs by real time reverse transcriptase-polymerase chain reaction. J. Lipid Res. 2002 Dec; 43(12): 2180-7. PMID: 12454281, ISSN: 0022-2275.

Yoshida H, Hasty AH, Major AS, Ishiguro H, Su YR, Gleaves LA, Babaev VR, Linton MF, Fazio S. Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice. Circulation. 2001 Dec 12/4/2001; 104(23): 2820-5. PMID: 11733401, ISSN: 1524-4539.

Major AS, Dove DE, Ishiguro H, Su YR, Brown AM, Liu L, Carter KJ, Linton MF, Fazio S. Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice. Arterioscler. Thromb. Vasc. Biol. 2001 Nov; 21(11): 1790-5. PMID: 11701467, ISSN: 1524-4636.

Su YR, Menon AG. Epithelial sodium channels and hypertension. Drug Metab. Dispos. 2001 Apr; 29(4 Pt 2): 553-6. PMID: 11259350, ISSN: 0090-9556.

Rutkowski MP, Klanke CA, Su YR, Reif M, Menon AG. Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension. 1998 Jun; 31(6): 1230-4. PMID: 9622134, ISSN: 0194-911X.

Cui Y, Su YR, Rutkowski M, Reif M, Menon AG, Pun RY. Loss of protein kinase C inhibition in the beta-T594M variant of the amiloride-sensitive Na+ channel. Proc. Natl. Acad. Sci. U.S.A. 1997 Sep 9/2/1997; 94(18): 9962-6. PMID: 9275234, PMCID: PMC23310, ISSN: 0027-8424.

Su YR, Rutkowski MP, Klanke CA, Wu X, Cui Y, Pun RY, Carter V, Reif M, Menon AG. A novel variant of the beta-subunit of the amiloride-sensitive sodium channel in African Americans. J. Am. Soc. Nephrol. 1996 Dec; 7(12): 2543-9. PMID: 8989732, ISSN: 1046-6673.

Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M. Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. Genomics. 1995 Feb 2/10/1995; 25(3): 615-22. PMID: 7759094, ISSN: 0888-7543.

Klanke CA, Su YR, Varvil TS, Otterud BE, Leppert M, Menon AG. Dinucleotide repeat polymorphism from a cosmid containing the human anion exchanger isoform 3 (SLC2C) gene. Hum. Mol. Genet. 1994 Nov; 3(11): 2086. PMID: 7874147, ISSN: 0964-6906.

Su YR, Klanke CA, Houseal TW, Linn SC, Burk SE, Varvil TS, Otterud BE, Shull GE, Leppert MF, Menon AG. Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36. Genomics. 1994 Aug; 22(3): 605-9. PMID: 8001971, PII: S0888-7543(84)71433-9, DOI: 10.1006/geno.1994.1433, ISSN: 0888-7543.