Jeremy Lynn Norris, Ph.D.

Research Associate Professor

j.norris@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Biochemistry
Education
Ph.D., Chemistry, Vanderbilt University, Nashville, TennesseeB.S., Chemistry, University of Tennessee Center for Health Science, Memphis, Tennessee
Office Address
9160 Medical Research Building III
465 21st Avenue South
Nashville, TN 37232
Publications
Heaven MR, Cobbs AL, Nei YW, Gutierrez DB, Herren AW, Gunawardena HP, Caprioli RM, Norris JL. MicroDIA (µDIA): data-independent acquisition for high-throughput proteomics and sensitive peptide mass spectrum identification. Anal. Chem [print-electronic]. 2018 Jul 7/9/2018; PMID: 29984981, DOI: 10.1021/acs.analchem.8b01026, ISSN: 1520-6882.

Yang B, Patterson NH, Tsui T, Caprioli RM, Norris JL. Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation. J. Am. Soc. Mass Spectrom [print-electronic]. 2018 May; 29(5): 1012-20. PMID: 29536413, PMCID: PMC5943162, PII: 10.1007/s13361-018-1899-9, DOI: 10.1007/s13361-018-1899-9, ISSN: 1879-1123.

Rizzo DG, Prentice BM, Moore JL, Norris JL, Caprioli RM. Enhanced Spatially Resolved Proteomics Using On-Tissue Hydrogel-Mediated Protein Digestion. Anal. Chem [print-electronic]. 2017 Mar 3/7/2017; 89(5): 2948-55. PMID: 28193007, DOI: 10.1021/acs.analchem.6b04395, ISSN: 1520-6882.

Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan AT, Burns W, Poland JC, Romer CE, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell NA, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM. An integrated, high-throughput, multi-omics platform enables data-driven construction of cellular responses and reveals global drug mechanisms of action. J. Proteome Res [print-electronic]. 2017 Jan 1/14/2017; PMID: 28088864, DOI: 10.1021/acs.jproteome.6b01004, ISSN: 1535-3907.

Zubair F, Laibinis PE, Swisher WG, Yang J, Spraggins JM, Norris JL, Caprioli RM. Trypsin and MALDI matrix pre-coated targets simplify sample preparation for mapping proteomic distributions within biological tissues by imaging mass spectrometry. J Mass Spectrom. 2016 Dec; 51(12): 1168-79. PMID: 27676701, DOI: 10.1002/jms.3888, ISSN: 1096-9888.

Prentice BM, Chumbley CW, Hachey BC, Norris JL, Caprioli RM. Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification. Anal. Chem [print-electronic]. 2016 Oct 10/4/2016; 88(19): 9780-8. PMID: 27573922, DOI: 10.1021/acs.analchem.6b02821, ISSN: 1520-6882.

Zubair F, Prentice BM, Norris JL, Laibinis PE, Caprioli RM. Standard Reticle Slide To Objectively Evaluate Spatial Resolution and Instrument Performance in Imaging Mass Spectrometry. Anal. Chem [print-electronic]. 2016 Jul 7/19/2016; 88(14): 7302-11. PMID: 27299987, DOI: 10.1021/acs.analchem.6b01655, ISSN: 1520-6882.

Heaven MR, Funk AJ, Cobbs AL, Haffey WD, Norris JL, McCullumsmith RE, Greis KD. Systematic evaluation of data-independent acquisition for sensitive and reproducible proteomics-a prototype design for a single injection assay. J Mass Spectrom. 2016 Jan; 51(1): 1-11. PMID: 26757066, PMCID: PMC4712743, DOI: 10.1002/jms.3716, ISSN: 1096-9888.

Norris JL, Tsui T, Gutierrez DB, Caprioli RM. Pathology interface for the molecular analysis of tissue by mass spectrometry. J Pathol Inform. 2016; 7: 13. PMID: 27141319, PMCID: PMC4837791, PII: JPI-7-13, DOI: 10.4103/2153-3539.179903, ISSN: 2229-5089.

Norris JL, Bierbaum VM. Focus on Imaging Mass Spectrometry, Honoring Dr. Richard M. Caprioli, Recipient of the 2014 ASMS Award for a Distinguished Contribution in Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2015 Jun; 26(6): 847-9. PMID: 25893272, DOI: 10.1007/s13361-015-1138-6, ISSN: 1879-1123.

Taverna D, Norris JL, Caprioli RM. Histology-directed microwave assisted enzymatic protein digestion for MALDI MS analysis of mammalian tissue. Anal. Chem [print-electronic]. 2015 Jan 1/6/2015; 87(1): 670-6. PMID: 25427280, PMCID: PMC4287167, DOI: 10.1021/ac503479a, ISSN: 1520-6882.

Manier ML, Spraggins JM, Reyzer ML, Norris JL, Caprioli RM. A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry. J Mass Spectrom. 2014 Aug; 49(8): 665-73. PMID: 25044893, PMCID: PMC4126081, DOI: 10.1002/jms.3411, ISSN: 1096-9888.

Gessel MM, Norris JL, Caprioli RM. MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery. J Proteomics [print-electronic]. 2014 Jul 7/31/2014; 107: 71-82. PMID: 24686089, PMCID: PMC4104210, PII: S1874-3919(14)00143-2, DOI: 10.1016/j.jprot.2014.03.021, ISSN: 1876-7737.

Schmidt MJ, Horvath S, Ebert P, Norris JL, Seeley EH, Brown J, Gellert L, Everheart M, Garbett KA, Grice TW, Caprioli RM, Mirnics K. Modulation of behavioral networks by selective interneuronal inactivation. Mol. Psychiatry [print-electronic]. 2014 May; 19(5): 580-7. PMID: 24322205, PMCID: PMC4179403, PII: mp2013167, DOI: 10.1038/mp.2013.167, ISSN: 1476-5578.

Norris JL, Caprioli RM. Imaging mass spectrometry: a new tool for pathology in a molecular age. Proteomics Clin Appl. 2013 Dec; 7(11-12): 733-8. PMID: 24178781, PMCID: PMC3919023, DOI: 10.1002/prca.201300055, ISSN: 1862-8354.

Norris JL, Caprioli RM. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem. Rev [print-electronic]. 2013 Apr 4/10/2013; 113(4): 2309-42. PMID: 23394164, PMCID: PMC3624074, DOI: 10.1021/cr3004295, ISSN: 1520-6890.

Zavalin A, Todd EM, Rawhouser PD, Yang J, Norris JL, Caprioli RM. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. J Mass Spectrom. 2012 Nov; 47(11): 1473-81. PMID: 23147824, DOI: 10.1002/jms.3108, ISSN: 1096-9888.

Zavalin A, Todd EM, Rawhouser PD, Yang J, Norris JL, Caprioli RM. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. J Mass Spectrom. 2012 Nov; 47(11): i. PMID: 23147833, PMCID: PMC3507384, DOI: 10.1002/jms.3132, ISSN: 1096-9888.

Yang J, Chaurand P, Norris JL, Porter NA, Caprioli RM. Activity-based probes linked with laser-cleavable mass tags for signal amplification in imaging mass spectrometry: analysis of serine hydrolase enzymes in mammalian tissue. Anal. Chem [print-electronic]. 2012 Apr 4/17/2012; 84(8): 3689-95. PMID: 22424244, PMCID: PMC3328658, DOI: 10.1021/ac300203v, ISSN: 1520-6882.

Kellie JF, Catherman AD, Durbin KR, Tran JC, Tipton JD, Norris JL, Witkowski CE, Thomas PM, Kelleher NL. Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. Anal. Chem [print-electronic]. 2012 Jan 1/3/2012; 84(1): 209-15. PMID: 22103811, PMCID: PMC3262231, DOI: 10.1021/ac202384v, ISSN: 1520-6882.

Walworth MJ, ElNaggar MS, Stankovich JJ, Witkowski C, Norris JL, Van Berkel GJ. Direct sampling and analysis from solid-phase extraction cards using an automated liquid extraction surface analysis nanoelectrospray mass spectrometry system. Rapid Commun. Mass Spectrom. 2011 Sep 9/15/2011; 25(17): 2389-96. PMID: 21793068, DOI: 10.1002/rcm.5132, ISSN: 1097-0231.

Razis E, Selviaridis P, Labropoulos S, Norris JL, Zhu MJ, Song DD, Kalebic T, Torrens M, Kalogera-Fountzila A, Karkavelas G, Karanastasi S, Fletcher JA, Fountzilas G. Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment. Clin. Cancer Res [print-electronic]. 2009 Oct 10/1/2009; 15(19): 6258-66. PMID: 19789313, PII: 1078-0432.CCR-08-1867, DOI: 10.1158/1078-0432.CCR-08-1867, ISSN: 1078-0432.

Harkins JB, Katz BB, Pastor SJ, Osucha P, Hafeman DG, Witkowski CE, Norris JL. Parallel electrophoretic depletion, fractionation, concentration, and desalting of 96 complex biological samples for mass spectrometry. Anal. Chem [print-electronic]. 2008 Apr 4/15/2008; 80(8): 2734-43. PMID: 18331003, DOI: 10.1021/ac702214n, ISSN: 1520-6882.

Chen EI, Cociorva D, Norris JL, Yates JR. Optimization of mass spectrometry-compatible surfactants for shotgun proteomics. J. Proteome Res [print-electronic]. 2007 Jul; 6(7): 2529-38. PMID: 17530876, PMCID: PMC2570269, DOI: 10.1021/pr060682a, ISSN: 1535-3893.

M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem. Biophys. Res. Commun [print-electronic]. 2007 Feb 2/16/2007; 353(3): 829-34. PMID: 17194448, PMCID: PMC2562600, PII: S0006-291X(06)02787-2, DOI: 10.1016/j.bbrc.2006.12.111, ISSN: 0006-291X.

Norris JL, Cornett DS, Mobley JA, Andersson M, Seeley EH, Chaurand P, Caprioli RM. Processing MALDI Mass Spectra to Improve Mass Spectral Direct Tissue Analysis. Int J Mass Spectrom. 2007 Feb 2/1/2007; 260(2-3): 212-21. PMID: 17541451, PMCID: PMC1885223, DOI: 10.1016/j.ijms.2006.10.005, ISSN: 1387-3806.

Chaurand P, Norris JL, Cornett DS, Mobley JA, Caprioli RM. New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry. J. Proteome Res. 2006 Nov; 5(11): 2889-900. PMID: 17081040, DOI: 10.1021/pr060346u, ISSN: 1535-3893.

Meistermann H, Norris JL, Aerni HR, Cornett DS, Friedlein A, Erskine AR, Augustin A, De Vera Mudry MC, Ruepp S, Suter L, Langen H, Caprioli RM, Ducret A. Biomarker discovery by imaging mass spectrometry: transthyretin is a biomarker for gentamicin-induced nephrotoxicity in rat. Mol. Cell Proteomics [print-electronic]. 2006 Oct; 5(10): 1876-86. PMID: 16705188, PII: M500399-MCP200, DOI: 10.1074/mcp.M500399-MCP200, ISSN: 1535-9476.

Luka Z, Ham AJ, Norris JL, Yeo EJ, Yermalitsky V, Glenn B, Caprioli RM, Liebler DC, Wagner C. Identification of phosphorylation sites in glycine N-methyltransferase from rat liver. Protein Sci [print-electronic]. 2006 Apr; 15(4): 785-94. PMID: 16522797, PMCID: PMC2242492, PII: ps.051906706, DOI: 10.1110/ps.051906706, ISSN: 0961-8368.

Norris, JL. Automated Cell-Type Specific Molecular Profiling by Imaging Mass Spectrometry [editorial]. American Biotechnology Laboratory. 2006; 9((24)): 20-2.

Norris JL, Hangauer MJ, Porter NA, Caprioli RM. Nonacid cleavable detergents applied to MALDI mass spectrometry profiling of whole cells. J Mass Spectrom. 2005 Oct; 40(10): 1319-26. PMID: 16220468, DOI: 10.1002/jms.914, ISSN: 1076-5174.

Norris JL, Porter NA, Caprioli RM. Combination detergent/MALDI matrix: functional cleavable detergents for mass spectrometry. Anal. Chem. 2005 Aug 8/1/2005; 77(15): 5036-40. PMID: 16053319, DOI: 10.1021/ac050460g, ISSN: 0003-2700.

Pierson J, Norris JL, Aerni HR, Svenningsson P, Caprioli RM, Andrén PE. Molecular profiling of experimental Parkinson's disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry. J. Proteome Res. 2004 Mar; 3(2): 289-95. PMID: 15113106, ISSN: 1535-3893.

Masterson DS, Yin H, Chacon A, Hachey DL, Norris JL, Porter NA. Lysine peroxycarbamates: free radical-promoted peptide cleavage. J. Am. Chem. Soc. 2004 Jan 1/28/2004; 126(3): 720-1. PMID: 14733538, DOI: 10.1021/ja038615u, ISSN: 0002-7863.

Norris JL, Porter NA, Caprioli RM. Mass spectrometry of intracellular and membrane proteins using cleavable detergents. Anal. Chem. 2003 Dec 12/1/2003; 75(23): 6642-7. PMID: 14640740, DOI: 10.1021/ac034802z, ISSN: 0003-2700.