Weisong Zhou, Ph.D.

Research Associate Professor

Faculty Appointments
Research Associate Professor of Medicine
Ph.D., Veterinary Science, University of Kentucky, Lexington, KentuckyM.S., Veterinary Science, Yangzhou University, Yangzhou, ChinaB.S., Meat Hygiene, Yangzhou University, Yangzhou, China
Office Address
T-1218 MCN
TN 2650
Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect. Immun [print-electronic]. 2014 Sep; 82(9): 3723-39. PMID: 24958709, PMCID: PMC4187810, PII: IAI.00035-14, DOI: 10.1128/IAI.00035-14, ISSN: 1098-5522.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825.

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J. Virol [print-electronic]. 2014 Sep 9/1/2014; 88(17): 9655-72. PMID: 24920804, PMCID: PMC4136353, PII: JVI.03299-13, DOI: 10.1128/JVI.03299-13, ISSN: 1098-5514.

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax [print-electronic]. 2013 Aug; 68(8): 717-23. PMID: 23422214, PMCID: PMC3916091, PII: thoraxjnl-2012-202404, DOI: 10.1136/thoraxjnl-2012-202404, ISSN: 1468-3296.

Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS ONE [print-electronic]. 2012; 7(5): e33518. PMID: 22590492, PMCID: PMC3349674, PII: PONE-D-10-03779, DOI: 10.1371/journal.pone.0033518, ISSN: 1932-6203.

Boswell MG, Zhou W, Newcomb DC, Peebles RS. PGI2 as a regulator of CD4+ subset differentiation and function. Prostaglandins Other Lipid Mediat [print-electronic]. 2011 Nov; 96(1-4): 21-6. PMID: 21864703, PMCID: PMC3215832, PII: S1098-8823(11)00073-6, DOI: 10.1016/j.prostaglandins.2011.08.003, ISSN: 1098-8823.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504.

Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J. Allergy Clin. Immunol [print-electronic]. 2011 Apr; 127(4): 1006-13.e1. PMID: 21236478, PMCID: PMC3916096, PII: S0091-6749(10)01865-8, DOI: 10.1016/j.jaci.2010.11.043, ISSN: 1097-6825.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J. Immunol [print-electronic]. 2009 Aug 8/1/2009; 183(3): 2016-26. PMID: 19587017, PMCID: PMC3755459, PII: jimmunol.0803167, DOI: 10.4049/jimmunol.0803167, ISSN: 1550-6606.

Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J. Immunol. 2009 May 5/1/2009; 182(9): 5317-21. PMID: 19380778, PMCID: PMC3711250, PII: 182/9/5317, DOI: 10.4049/jimmunol.0803868, ISSN: 1550-6606.

Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol. 2008 Oct 10/15/2008; 181(8): 5360-7. PMID: 18832692, PII: 181/8/5360, ISSN: 1550-6606.

Moore ML, Chi MH, Zhou W, Goleniewska K, O'Neal JF, Higginbotham JN, Peebles RS. Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity. J. Immunol. 2007 Mar 3/1/2007; 178(5): 2651-4. PMID: 17312105, PII: 178/5/2651, ISSN: 0022-1767.

Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J. Leukoc. Biol [print-electronic]. 2007 Mar; 81(3): 809-17. PMID: 17135575, PII: jlb.0606375, DOI: 10.1189/jlb.0606375, ISSN: 0741-5400.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J. Immunol. 2007 Jan 1/15/2007; 178(2): 702-10. PMID: 17202330, PII: 178/2/702, ISSN: 0022-1767.

Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O'Neal JF, Graham BS, Peebles RS. IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect [print-electronic]. 2006 Nov; 8(14-15): 2880-9. PMID: 17110149, PMCID: PMC1811125, PII: S1286-4579(06)00351-0, DOI: 10.1016/j.micinf.2006.09.007, ISSN: 1286-4579.

Peebles RS, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J. Immunol. 2005 Dec 12/15/2005; 175(12): 8253-9. PMID: 16339565, PII: 175/12/8253, ISSN: 0022-1767.

Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK, Dubin PJ, Sheller JR, Goleniewska K, O'Neal JF, Olson SJ, Mitchell D, Graham BS, Peebles RS. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J. Allergy Clin. Immunol. 2005 Sep; 116(3): 550-7. PMID: 16159623, PII: S0091-6749(05)01278-9, DOI: 10.1016/j.jaci.2005.03.051, ISSN: 0091-6749.

Cook RF, Cook SJ, Bolin PS, Howe LJ, Zhou W, Montelaro RC, Issel CJ. Genetic immunization with codon-optimized equine infectious anemia virus (EIAV) surface unit (SU) envelope protein gene sequences stimulates immune responses in ponies. Vet. Microbiol. 2005 Jun 6/15/2005; 108(1-2): 23-37. PMID: 15885929, PII: S0378-1135(05)00136-7, DOI: 10.1016/j.vetmic.2005.04.004, ISSN: 0378-1135.

Hashimoto K, Sheller JR, Morrow JD, Collins RD, Goleniewska K, O'Neal J, Zhou W, Ji S, Mitchell DB, Graham BS, Peebles RS. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J. Immunol. 2005 Jan 1/1/2005; 174(1): 525-32. PMID: 15611279, PII: 174/1/525, ISSN: 0022-1767.

Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K, Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright PF, Collins RD, Suzutani T, Peebles RS. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. J. Virol. 2004 Oct; 78(19): 10303-9. PMID: 15367596, PMCID: PMC516432, PII: 78/19/10303, DOI: 10.1128/JVI.78.19.10303-10309.2004, ISSN: 0022-538X.

Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF, Peebles RS. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am. J. Respir. Crit. Care Med [print-electronic]. 2004 Aug 8/1/2004; 170(3): 306-12. PMID: 15130904, PII: 200301-030OC, DOI: 10.1164/rccm.200301-030OC, ISSN: 1073-449X.

Zhou W, Chang S, Aune TM. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 2004 Feb 2/24/2004; 101(8): 2440-5. PMID: 14983028, PMCID: PMC356969, PII: 101/8/2440, ISSN: 0027-8424.

Zhou W, Zhang F, Aune TM. Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells. J. Immunol. 2003 Jan 1/15/2003; 170(2): 735-40. PMID: 12517935, ISSN: 0022-1767.

Soutto M, Zhou W, Aune TM. Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells. J. Immunol. 2002 Dec 12/15/2002; 169(12): 6664-7. PMID: 12471094, ISSN: 0022-1767.

Zhou W, Cook RF, Cook SJ, Hammond SA, Rushlow K, Ghabrial NN, Berger SL, Montelaro RC, Issel CJ. Multiple RNA splicing and the presence of cryptic RNA splice donor and acceptor sites may contribute to low expression levels and poor immunogenicity of potential DNA vaccines containing the env gene of equine infectious anemia virus (EIAV). Vet. Microbiol. 2002 Aug 8/25/2002; 88(2): 127-51. PMID: 12135633, PII: S0378113502000998, ISSN: 0378-1135.