Kenneth J. Holroyd, M.D., M.B.A.

Associate Professor
Faculty Appointments
Vice President for Tech Transfer Associate Professor of Anesthesiology Associate Professor of Medicine
M.B.A., MBA/MED SEV M, Johns Hopkins University, Baltimore, MarylandM.D., Medicine, Johns Hopkins University, Baltimore, MarylandB.A., Natural Science, Johns Hopkins University, Baltimore, Maryland
Office Address
Center for Technology Transfer and Commercialization, 1207 17th Ave South, Suite 105
Nashville, TN 37212
Pulley JM, Jerome RN, Shirey-Rice JK, Zaleski NM, Naylor HM, Pruijssers AJ, Jackson JC, Bernard GR, Holroyd KJ. Advocating for mutually beneficial access to shelved compounds. Future Med Chem [print-electronic]. 2018 Jun 6/1/2018; 10(12): 1395-8. PMID: 29788759, DOI: 10.4155/fmc-2018-0090, ISSN: 1756-8927.

Pulley JM, Jerome RN, Ogletree ML, Bernard GR, Lavieri RR, Zaleski NM, Hong CC, Shirey-Rice JK, Arteaga CL, Mayer IA, Holroyd KJ, Cook RS. Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program. Target Oncol. 2018 Feb; 13(1): 61-8. PMID: 29218624, PMCID: PMC5826865, PII: 10.1007/s11523-017-0542-1, DOI: 10.1007/s11523-017-0542-1, ISSN: 1776-260X.

Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ. When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data. Assay Drug Dev Technol [print-electronic]. 2017 Dec; 15(8): 354-61. PMID: 29193979, PMCID: PMC5731541, DOI: 10.1089/adt.2017.821, ISSN: 1557-8127.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay Drug Dev Technol [print-electronic]. 2017 Apr; 15(3): 113-9. PMID: 28379727, PMCID: PMC5399743, DOI: 10.1089/adt.2016.772, ISSN: 1557-8127.

Lipsky BA, Holroyd KJ, Zasloff M. Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin. Infect. Dis. 2008 Dec 12/15/2008; 47(12): 1537-45. PMID: 18990064, DOI: 10.1086/593185, ISSN: 1537-6591.

Hauber HP, Bergeron C, Toda M, Kontolemos M, Holroyd KJ, Levitt RC, Hamid Q. Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge. Allergy Asthma Clin Immunol [print-electronic]. 2007 Mar 3/15/2007; 3(1): 19-23. PMID: 20525149, PMCID: PMC2873628, PII: 1710-1492-3-1-19, DOI: 10.1186/1710-1492-3-1-19, ISSN: 1710-1492.

Hauber HP, Bergeron C, Tsicopoulos A, Wallaert B, Olivenstein R, Holroyd KJ, Levitt RC, Hamid Q. Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis. Can. Respir. J. 2005 Apr; 12(3): 143-6. PMID: 15875066, DOI: 10.1155/2005/531432, ISSN: 1198-2241.

Hauber HP, Tsicopoulos A, Wallaert B, Griffin S, McElvaney NG, Daigneault P, Mueller Z, Olivenstein R, Holroyd KJ, Levitt RC, Hamid Q. Expression of HCLCA1 in cystic fibrosis lungs is associated with mucus overproduction. Eur. Respir. J. 2004 Jun; 23(6): 846-50. PMID: 15218996, ISSN: 0903-1936.

Ciulla TA, Criswell MH, Danis RP, Williams JI, McLane MP, Holroyd KJ. Squalamine lactate reduces choroidal neovascularization in a laser-injury model in the rat. Retina (Philadelphia, Pa.). 2003 Dec; 23(6): 808-14. PMID: 14707832, ISSN: 0275-004X.

Herbst RS, Hammond LA, Carbone DP, Tran HT, Holroyd KJ, Desai A, Williams JI, Bekele BN, Hait H, Allgood V, Solomon S, Schiller JH. A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Clin. Cancer Res. 2003 Sep 9/15/2003; 9(11): 4108-15. PMID: 14519633, ISSN: 1078-0432.

Hao D, Hammond LA, Eckhardt SG, Patnaik A, Takimoto CH, Schwartz GH, Goetz AD, Tolcher AW, McCreery HA, Mamun K, Williams JI, Holroyd KJ, Rowinsky EK. A Phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor. Clin. Cancer Res. 2003 Jul; 9(7): 2465-71. PMID: 12855619, ISSN: 1078-0432.

Hauber HP, Manoukian JJ, Nguyen LH, Sobol SE, Levitt RC, Holroyd KJ, McElvaney NG, Griffin S, Hamid Q. Increased expression of interleukin-9, interleukin-9 receptor, and the calcium-activated chloride channel hCLCA1 in the upper airways of patients with cystic fibrosis. Laryngoscope. 2003 Jun; 113(6): 1037-42. PMID: 12782818, DOI: 10.1097/00005537-200306000-00022, ISSN: 0023-852X.

Ge Y, MacDonald D, Hait H, Lipsky B, Zasloff M, Holroyd K. Microbiological profile of infected diabetic foot ulcers [letter]. Diabet. Med. 2002 Dec; 19(12): 1032-4. PMID: 12647846, ISSN: 0742-3071.

Genaidy M, Kazi AA, Peyman GA, Passos-Machado E, Farahat HG, Williams JI, Holroyd KJ, Blake DA. Effect of squalamine on iris neovascularization in monkeys. Retina (Philadelphia, Pa.). 2002 Dec; 22(6): 772-8. PMID: 12476105, ISSN: 0275-004X.

Bhargava P, Marshall JL, Dahut W, Rizvi N, Trocky N, Williams JI, Hait H, Song S, Holroyd KJ, Hawkins MJ. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin. Cancer Res. 2001 Dec; 7(12): 3912-9. PMID: 11751482, ISSN: 1078-0432.

Zasloff M, Williams JI, Chen Q, Anderson M, Maeder T, Holroyd K, Jones S, Kinney W, Cheshire K, McLane M. A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. Int. J. Obes. Relat. Metab. Disord. 2001 May; 25(5): 689-97. PMID: 11360152, DOI: 10.1038/sj.ijo.0801599.

Williams JI, Weitman S, Gonzalez CM, Jundt CH, Marty J, Stringer SD, Holroyd KJ, Mclane MP, Chen Q, Zasloff M, Von Hoff DD. Squalamine treatment of human tumors in nu/nu mice enhances platinum-based chemotherapies. Clin. Cancer Res. 2001 Mar; 7(3): 724-33. PMID: 11297269, ISSN: 1078-0432.

Bhathena PR, Comhair SA, Holroyd KJ, Erzurum SC. Interleukin-9 receptor expression in asthmatic airways In vivo. Lung. 2000; 178(3): 149-60. PMID: 10871433, PII: 10.1007/s004080000018, ISSN: 0341-2040.

Shimbara A, Christodoulopoulos P, Soussi-Gounni A, Olivenstein R, Nakamura Y, Levitt RC, Nicolaides NC, Holroyd KJ, Tsicopoulos A, Lafitte JJ, Wallaert B, Hamid QA. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J. Allergy Clin. Immunol. 2000 Jan; 105(1 Pt 1): 108-15. PMID: 10629460, PII: S0091674900999573, ISSN: 0091-6749.

Ge Y, MacDonald D, Henry MM, Hait HI, Nelson KA, Lipsky BA, Zasloff MA, Holroyd KJ. In vitro susceptibility to pexiganan of bacteria isolated from infected diabetic foot ulcers. Diagn. Microbiol. Infect. Dis. 1999 Sep; 35(1): 45-53. PMID: 10529881, PII: S0732-8893(99)00056-5, ISSN: 0732-8893.

Dong Q, Louahed J, Vink A, Sullivan CD, Messler CJ, Zhou Y, Haczku A, Huaux F, Arras M, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur. J. Immunol. 1999 Jul; 29(7): 2130-9. PMID: 10427975, DOI: 10.1002/(SICI)1521-4141(199907)29:07<2130::AID-IMMU2130>3.0.CO;2-S, ISSN: 0014-2980.

Levitt RC, McLane MP, MacDonald D, Ferrante V, Weiss C, Zhou T, Holroyd KJ, Nicolaides NC. IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders. J. Allergy Clin. Immunol. 1999 May; 103(5 Pt 2): S485-91. PMID: 10329852, PII: S0091-6749(99)70165-X, ISSN: 0091-6749.

Ge Y, MacDonald DL, Holroyd KJ, Thornsberry C, Wexler H, Zasloff M. In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob. Agents Chemother. 1999 Apr; 43(4): 782-8. PMID: 10103181, PMCID: PMC89207, ISSN: 0066-4804.

McLane MP, Haczku A, van de Rijn M, Weiss C, Ferrante V, MacDonald D, Renauld JC, Nicolaides NC, Holroyd KJ, Levitt RC. Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. Am. J. Respir. Cell Mol. Biol. 1998 Nov; 19(5): 713-20. PMID: 9806735, DOI: 10.1165/ajrcmb.19.5.3457, ISSN: 1044-1549.

Grasso L, Huang M, Sullivan CD, Messler CJ, Kiser MB, Dragwa CR, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC. Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor. J. Biol. Chem. 1998 Sep 9/11/1998; 273(37): 24016-24. PMID: 9727018, ISSN: 0021-9258.

Holroyd KJ, Martinati LC, Trabetti E, Scherpbier T, Eleff SM, Boner AL, Pignatti PF, Kiser MB, Dragwa CR, Hubbard F, Sullivan CD, Grasso L, Messler CJ, Huang M, Hu Y, Nicolaides NC, Buetow KH, Levitt RC. Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region. Genomics. 1998 Sep 9/1/1998; 52(2): 233-5. PMID: 9782093, PII: S0888-7543(98)95445-3, DOI: 10.1006/geno.1998.5445, ISSN: 0888-7543.

Kleeberger SR, Levitt RC, Zhang LY, Longphre M, Harkema J, Jedlicka A, Eleff SM, DiSilvestre D, Holroyd KJ. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nat. Genet. 1997 Dec; 17(4): 475-8. PMID: 9398854, DOI: 10.1038/ng1297-475, ISSN: 1061-4036.

Nicolaides NC, Holroyd KJ, Ewart SL, Eleff SM, Kiser MB, Dragwa CR, Sullivan CD, Grasso L, Zhang LY, Messler CJ, Zhou T, Kleeberger SR, Buetow KH, Levitt RC. Interleukin 9: a candidate gene for asthma. Proc. Natl. Acad. Sci. U.S.A. 1997 Nov 11/25/1997; 94(24): 13175-80. PMID: 9371819, PMCID: PMC24282, ISSN: 0027-8424.

Holroyd KJ, Eleff SM, Zhang LY, Jakab GJ, Kleeberger SR. Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice. Am. J. Physiol. 1997 Sep; 273(3 Pt 1): L595-602. PMID: 9316494, DOI: 10.1152/ajplung.1997.273.3.L595, ISSN: 0002-9513.

Levitt RC, Holroyd KJ. Fine-structure mapping of genes providing susceptibility to asthma on chromosome 5q31-q33. Clin. Exp. Allergy. 1995 Nov; 25 Suppl 2: 119-23. PMID: 8590330, ISSN: 0954-7894.

Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N. Engl. J. Med. 1995 Oct 10/5/1995; 333(14): 894-900. PMID: 7666875, DOI: 10.1056/NEJM199510053331402, ISSN: 0028-4793.

Xu J, Levitt RC, Panhuysen CI, Postma DS, Taylor EW, Amelung PJ, Holroyd KJ, Bleecker ER, Meyers DA. Evidence for two unlinked loci regulating total serum IgE levels. Am. J. Hum. Genet. 1995 Aug; 57(2): 425-30. PMID: 7668269, PMCID: PMC1801566, ISSN: 0002-9297.

Holroyd KJ, Merritt WT. Insertion of a lumbar drain using a pediatric central venous catheter guidewire [letter]. Anesthesiology. 1995 Aug; 83(2): 430-1. PMID: 7631971, ISSN: 0003-3022.

Monitto CL, Levitt RC, DiSilvestre D, Holroyd KJ. Localization of the A3 adenosine receptor gene (ADORA3) to human chromosome 1p. Genomics. 1995 Apr 4/10/1995; 26(3): 637-8. PMID: 7607699, ISSN: 0888-7543.

Fleisher LA, Skolnick ED, Holroyd KJ, Lehmann HP. Coronary artery revascularization before abdominal aortic aneurysm surgery: a decision analytic approach. Anesth. Analg. 1994 Oct; 79(4): 661-9. PMID: 7943772, ISSN: 0003-2999.

Holroyd KJ, Buhl R, Borok Z, Roum JH, Bokser AD, Grimes GJ, Czerski D, Cantin AM, Crystal RG. Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment. Thorax. 1993 Oct; 48(10): 985-9. PMID: 8256245, PMCID: PMC464806, ISSN: 0040-6376.

Holroyd K, Lui M, Beattie C. Intraarterial vasodilator administration to restore pulse oximeter function. Anesthesiology. 1993 Aug; 79(2): 388-90. PMID: 8342849, ISSN: 0003-3022.

Buhl R, Jaffe HA, Holroyd KJ, Borok Z, Roum JH, Mastrangeli A, Wells FB, Kirby M, Saltini C, Crystal RG. Activation of alveolar macrophages in asymptomatic HIV-infected individuals. J. Immunol. 1993 Feb 2/1/1993; 150(3): 1019-28. PMID: 8380824, ISSN: 0022-1767.

Borok Z, Buhl R, Grimes GJ, Bokser AD, Hubbard RC, Holroyd KJ, Roum JH, Czerski DB, Cantin AM, Crystal RG. Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Lancet. 1991 Jul 7/27/1991; 338(8761): 215-6. PMID: 1676780, PII: 0140-6736(91)90350-X, ISSN: 0140-6736.

Jaffe HA, Buhl R, Mastrangeli A, Holroyd KJ, Saltini C, Czerski D, Jaffe HS, Kramer S, Sherwin S, Crystal RG. Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-gamma to the human lung. J. Clin. Invest. 1991 Jul; 88(1): 297-302. PMID: 1905329, PMCID: PMC296032, DOI: 10.1172/JCI115291, ISSN: 0021-9738.

Tamura N, Holroyd KJ, Banks T, Kirby M, Okayama H, Crystal RG. Diversity in junctional sequences associated with the common human V gamma 9 and V delta 2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease. J. Exp. Med. 1990 Jul 7/1/1990; 172(1): 169-81. PMID: 2141626, PMCID: PMC2188169, ISSN: 0022-1007.

Balbi B, Moller DR, Kirby M, Holroyd KJ, Crystal RG. Increased numbers of T lymphocytes with gamma delta-positive antigen receptors in a subgroup of individuals with pulmonary sarcoidosis. J. Clin. Invest. 1990 May; 85(5): 1353-61. PMID: 2110187, PMCID: PMC296580, DOI: 10.1172/JCI114579, ISSN: 0021-9738.

Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, Cantin AM, Crystal RG. Glutathione deficiency and HIV [letter]. Lancet. 1990 Mar 3/3/1990; 335(8688): 546. PMID: 1968559, PII: 0140-6736(90)90783-2, ISSN: 0140-6736.

Holroyd KJ, Tamura N, Banks T, Kirby M, Okayama H, Crystal RG. Limited diversity of gamma delta T-cell antigen receptor junctional region sequences in individuals with sarcoidosis compared to broad diversity in normal subjects. Trans. Assoc. Am. Physicians. 1990; 103: 102-11. PMID: 2151899, ISSN: 0066-9458.

Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, Cantin AM, Crystal RG. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet. 1989 Dec 12/2/1989; 2(8675): 1294-8. PMID: 2574255, PII: S0140-6736(89)91909-0, ISSN: 0140-6736.

Holroyd KJ, Reiner AP, Dick JD. Streptobacillus moniliformis polyarthritis mimicking rheumatoid arthritis: an urban case of rat bite fever. Am. J. Med. 1988 Nov; 85(5): 711-4. PMID: 3189374, PII: S0002-9343(88)80247-X, ISSN: 0002-9343.

Pumphrey JG, Holroyd K, Minton AP. Oxygen equilibrium of emulsified solutions of normal and sickle hemoglobin. Biochem. Biophys. Res. Commun. 1979 Jun 6/13/1979; 88(3): 980-7. PMID: 465092, PII: 0006-291X(79)91504-3, ISSN: 0006-291X.