Christopher S. Williams, Ph.D., M.D.


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Faculty Appointments
Professor of Medicine
M.D., Medicine, Vanderbilt University, Nashville, TennesseePh.D., Cell Biology, Vanderbilt University, Nashville, TennesseeB.Sc., Molecular Biology, Brigham Young University, Provo, Utah
Office Address
Gastroenterology Division -
1030-C Medical Research Building IV -
2215 Garland Avenue -
Nashville, TN 37232-0252
Research Description
Our research program focuses on understanding how the epithelium responds to injury and how normal injury response processes are subverted in the development of malignancy. The research activities span the basic to translational spectrum. We have three major research programs within the lab:

<b>1) Epigenetic control of intestinal epithelial wound healing and repair programs and relationship to colorectal oncogenesis. </b>
We are studying the role of the Myeloid Translocation Gene (MTGs) family in intestinal biology with emphasis on gut development, stem cell function, wound healing and malignancy. MTGR1 (Myeloid Translocation Gene, Related-1), MTG8 and MTG16 are members of a gene family originally identified as targets of chromosomal translocation in acute myeloid leukemia (AML). MTG family members act as transcriptional repressors and interact with other corepressors mSin3, N-CoR/SMRT and histone deacetylases (HDAC1-3). Chromosomal translocations often target master regulatory genes that affect growth, differentiation and apoptosis.

Using unique mouse models we are characterizing MTGs as modifiers of WNT dependent tumorigenesis in the gut and deterring how the regulate stem cell programs.

<b>2) Junctional signaling in mucosal wound healing responses and inflammatory carcinogenesis. </b>
We recently determined that a tight junction associated protein called BVES was suppressed by promoter methylation in colon cancer and that it regulates epithelial to mesenchymal transition (EMT) influencing metastasis.

We are currently cataloging the BVES protein interactome as a means to understand how BVES transduces "Out to In" signaling. In addition, using <i>Bves</i>-null mice, we are dissecting its role in intestinal wound healing using chemical, infectious, and mechanical colonic injury modeling and its role in colitis associated cancer.

<b> 3) Oxidative injury defenses in Inflammatory Bowel Disease (IBD) and colitis associated carcinoma (CAC). </b>
Little is known about the role of selenium and selenoproteins in inflammatory bowel disease (IBD), a condition of intermittent severe oxidative stress. We have shown that selenium deficiency results in increased mucosal injury and progression to colitis-associated dysplasia (CAD). Likewise, germ line Sepp1 and Gpx3 mutant mice had increased tumor burden with major effects on proliferation, apoptosis and DNA damage.

We hypothesize that intestinal Sepp1 alters the inflammatory microenvironment via clearance of reactive oxygen species thus affecting epithelial stem cell and differentiation programs. We are determining which stem cell pathways are modified by selenoproteins in influencing tumorigenesis.
Research Keywords
1) Epigenetic control of intestinal epithelial wound healing and repair programs and relationship to colorectal oncogenesis. 2) Junctional signaling in mucosal wound healing responses and inflammatory carcinogenesis. 3) Oxidative injury defenses in Inflammatory Bowel Disease (IBD) and colitis associated carcinoma (CAC).
Clinical Research Keywords
Inflammatory Bowel Disease Inflammational Carcinogenesis
Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature [print-electronic]. 2021 May; 593(7858): 282-8. PMID: 33828302, PMCID: PMC8122068, PII: 10.1038/s41586-021-03442-1, DOI: 10.1038/s41586-021-03442-1, ISSN: 1476-4687.

Short SP, Pilat JM, Barrett CW, Reddy VK, Haberman Y, Hendren JR, Marsh BJ, Keating CE, Motley AK, Hill KE, Zemper AE, Washington MK, Shi C, Chen X, Wilson KT, Hyams JS, Denson LA, Burk RF, Rosen MJ, Williams CS. Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. Gastroenterology [print-electronic]. 2021 Apr; 160(5): 1694-1708.e3. PMID: 33388316, PMCID: PMC8035252, PII: S0016-5085(20)35623-7, DOI: 10.1053/j.gastro.2020.12.059, ISSN: 1528-0012.

Kilonzo VW, Sasuclark AR, Torres DJ, Coyle C, Pilat JM, Williams CS, Pitts MW. Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice. Front Nutr. 2021; 8: 667587. PMID: 34026810, PMCID: PMC8138326, DOI: 10.3389/fnut.2021.667587, ISSN: 2296-861X.

Choksi YA, Chaparro J, Blanco M, Sharda R, Sarker S, Ferguson S, Higginbotham T, Hiremath G, Revetta F, Washington MK, Williams CS, Vaezi MF. Impedance and Histologic Characteristics of the Sub-Laryngeal Esophagus Distinguish Eosinophilic Esophagitis From Other Esophageal Disorders. Clin Gastroenterol Hepatol [print-electronic]. 2020 Jul; 18(8): 1727-1735.e2. PMID: 31589979, PMCID: PMC8019324, PII: S1542-3565(19)31081-X, DOI: 10.1016/j.cgh.2019.09.032, ISSN: 1542-7714.

Hale AT, Brown RE, Luka Z, Hudson BH, Matta P, Williams CS, York JD. Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Adv Biol Regul [print-electronic]. 2020 May; 76: 100694. PMID: 32019729, PMCID: PMC7230019, PII: S2212-4926(20)30005-1, DOI: 10.1016/j.jbior.2020.100694, ISSN: 2212-4934.

Permar SR, Ward RA, Barrett KJ, Freel SA, Gbadegesin RA, Kontos CD, Hu PJ, Hartmann KE, Williams CS, Vyas JM. Addressing the physician-scientist pipeline: strategies to integrate research into clinical training programs. J Clin Invest. 2020 Mar 3/2/2020; 130(3): 1058-61. PMID: 32039914, PMCID: PMC7269558, PII: 136181, DOI: 10.1172/JCI136181, ISSN: 1558-8238.

Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS. Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Oncogene [print-electronic]. 2019 Jun; 38(25): 5091-106. PMID: 30858547, PMCID: PMC6586520, PII: 10.1038/s41388-019-0777-7, DOI: 10.1038/s41388-019-0777-7, ISSN: 1476-5594.

Short SP, Thompson JJ, Bilotta AJ, Chen X, Revetta FL, Washington MK, Williams CS. Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells. Mol Cancer Res [print-electronic]. 2019 Apr; 17(4): 882-94. PMID: 30655319, PMCID: PMC6941354, PII: 1541-7786.MCR-18-0990, DOI: 10.1158/1541-7786.MCR-18-0990, ISSN: 1557-3125.

Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF. Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer. Mol Cancer Res [print-electronic]. 2019 Mar; 17(3): 697-708. PMID: 30606770, PMCID: PMC7387124, PII: 1541-7786.MCR-18-0666, DOI: 10.1158/1541-7786.MCR-18-0666, ISSN: 1557-3125.

Scoville EA, Allaman MM, Adams DW, Motley AK, Peyton SC, Ferguson SL, Horst SN, Williams CS, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease. Sci Rep. 2019 Feb 2/27/2019; 9(1): 2882. PMID: 30814550, PMCID: PMC6393448, PII: 10.1038/s41598-019-39232-z, DOI: 10.1038/s41598-019-39232-z, ISSN: 2045-2322.

Thompson JJ, Short SP, Parang B, Brown RE, Li C, Ng VH, Saito-Diaz K, Choksi YA, Washington MK, Smith JJ, Fingleton B, Brand T, Lee E, Coffey RJ, Williams CS. Blood vessel epicardial substance (BVES) reduces LRP6 receptor and cytoplasmic -catenin levels to modulate Wnt signaling and intestinal homeostasis. Carcinogenesis [print-electronic]. 2019 Jan 1/23/2019; PMID: 30689807, PMCID: PMC8067673, PII: 5299709, DOI: 10.1093/carcin/bgz007, ISSN: 1460-2180.

Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. Training the physician-scientist: views from program directors and aspiring young investigators. JCI Insight. 2018 Dec 12/6/2018; 3(23): PMID: 30518696, PMCID: PMC6328016, PII: 125651, DOI: 10.1172/jci.insight.125651, ISSN: 2379-3708.

Brown RE, Short SP, Williams CS. Colorectal Cancer and Metabolism. Curr Colorectal Cancer Rep [print-electronic]. 2018 Dec; 14(6): 226-41. PMID: 31406492, PMCID: PMC6690608, DOI: 10.1007/s11888-018-0420-y, ISSN: 1556-3790.

Short SP, Pilat JM, Williams CS. Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease. Free Radic. Biol. Med [print-electronic]. 2018 Nov 11/1/2018; 127: 26-35. PMID: 29778465, PII: S0891-5849(18)30890-6, DOI: 10.1016/j.freeradbiomed.2018.05.066, ISSN: 1873-4596.

Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT. Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene [print-electronic]. 2018 Sep 9/10/2018; PMID: 30202097, PII: 10.1038/s41388-018-0492-9, DOI: 10.1038/s41388-018-0492-9, ISSN: 1476-5594.

Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS. BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol [print-electronic]. 2018 Sep; 11(5): 1363-74. PMID: 29907869, PMCID: PMC6162166, PII: 10.1038/s41385-018-0043-2, DOI: 10.1038/s41385-018-0043-2, ISSN: 1935-3456.

Brown JJ, Short SP, Stencel-Baerenwald J, Urbanek K, Pruijssers AJ, McAllister N, Ikizler M, Taylor G, Aravamudhan P, Khomandiak S, Jabri B, Williams CS, Dermody TS. Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J. Virol [electronic-print]. 2018 May 5/15/2018; 92(10): PMID: 29514905, PMCID: PMC5923068, PII: JVI.02062-17, DOI: 10.1128/JVI.02062-17, ISSN: 1098-5514.

Blanchard M, Burton MC, Geraci MW, Madaio MP, Marsh JD, Proweller A, Rockey DC, Salata RA, Tan W, Williams CS, Zaidi M, Todd RF. Best Practices for Physician-Scientist Training Programs: Recommendations from the Alliance for Academic Internal Medicine. Am. J. Med [print-electronic]. 2018 May; 131(5): 578-84. PMID: 29410155, PII: S0002-9343(18)30087-1, DOI: 10.1016/j.amjmed.2018.01.015, ISSN: 1555-7162.

Saito-Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson JJ, Hyde AS, Sawyer LM, Jodoin JN, Santos E, Lee LA, Coffey RJ, Beauchamp RD, Williams CS, Kenworthy AK, Robbins DJ, Ahmed Y, Lee E. APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev. Cell. 2018 Mar 3/12/2018; 44(5): 566-581.e8. PMID: 29533772, PMCID: PMC5884143, PII: S1534-5807(18)30108-4, DOI: 10.1016/j.devcel.2018.02.013, ISSN: 1878-1551.

Thompson JJ, Williams CS. Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and Cancer. Genes (Basel). 2018 Feb 2/26/2018; 9(3): PMID: 29495399, PMCID: PMC5867842, PII: genes9030121, DOI: 10.3390/genes9030121, ISSN: 2073-4425.

Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics [print-electronic]. 2018 Jan; 14(1): PMID: 29681789, PMCID: PMC5907923, DOI: 10.1007/s11306-017-1311-y, ISSN: 1573-3882.

Parang B, Thompson JJ, Williams CS. Blood Vessel Epicardial Substance (BVES) in junctional signaling and cancer. Tissue Barriers [print-electronic]. 2018; 6(4): 1-12. PMID: 30307367, PMCID: PMC6389126, DOI: 10.1080/21688370.2018.1499843, ISSN: 2168-8370.

McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight [print-electronic]. 2017 Aug 8/17/2017; 2(16): PMID: 28814670, PMCID: PMC5621889, PII: 78210, DOI: 10.1172/jci.insight.78210, ISSN: 2379-3708.

Short SP, Costacurta PW, Williams CS. Using 3D Organoid Cultures to Model Intestinal Physiology and Colorectal Cancer. Curr Colorectal Cancer Rep [print-electronic]. 2017 Jun; 13(3): 183-91. PMID: 29276469, PMCID: PMC5736147, DOI: 10.1007/s11888-017-0363-8, ISSN: 1556-3790.

Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Gut [print-electronic]. 2017 May; 66(5): 852-62. PMID: 28389570, PMCID: PMC5385850, PII: gutjnl-2015-310255, DOI: 10.1136/gutjnl-2015-310255, ISSN: 1468-3288.

Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NA, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH. Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer. Mucosal Immunol [print-electronic]. 2017 Feb 2/15/2017; PMID: 28198364, PII: mi20179, DOI: 10.1038/mi.2017.9, ISSN: 1935-3456.

Short SP, Williams CS. Selenoproteins in Tumorigenesis and Cancer Progression. Adv. Cancer Res. 2017; 136: 49-83. PMID: 29054422, PMCID: PMC5819884, PII: S0065-230X(17)30038-6, DOI: 10.1016/bs.acr.2017.08.002, ISSN: 2162-5557.

Barrett CW, Short SP, Williams CS. Selenoproteins and oxidative stress-induced inflammatory tumorigenesis in the gut. Cell. Mol. Life Sci [print-electronic]. 2016 Aug 8/25/2016; PMID: 27563706, PII: 10.1007/s00018-016-2339-2, DOI: 10.1007/s00018-016-2339-2, ISSN: 1420-9071.

Barrett CW, Short SP, Choksi YA, Williams CS. Whole-mount Enteroid Proliferation Staining. Bio Protoc. 2016 Jun 6/20/2016; 6(12): PMID: 29333475, PMCID: PMC5760989, DOI: 10.21769/BioProtoc.1837, ISSN: 2331-8325.

Parang B, Bradley AM, Mittal MK, Short SP, Thompson JJ, Barrett CW, Naik RD, Bilotta AJ, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Hiebert SW, Williams CS. Myeloid translocation genes differentially regulate colorectal cancer programs. Oncogene [print-electronic]. 2016 Jun 6/6/2016; PMID: 27270437, PII: onc2016167, DOI: 10.1038/onc.2016.167, ISSN: 1476-5594.

Short SP, Whitten-Barrett C, Williams CS. Selenoprotein P in colitis-associated carcinoma. Mol Cell Oncol. 2016 May; 3(3): e1075094. PMID: 27314080, PMCID: PMC4909462, PII: 1075094, DOI: 10.1080/23723556.2015.1075094, ISSN: 2372-3556.

Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT. L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Inflamm. Bowel Dis [print-electronic]. 2016 Apr 4/21/2016; PMID: 27104830, DOI: 10.1097/MIB.0000000000000790, ISSN: 1536-4844.

Reddy VK, Short SP, Barrett CW, Mittal MK, Keating CE, Thompson JJ, Harris EI, Revetta F, Bader DM, Brand T, Washington MK, Williams CS. BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation. Stem Cells [print-electronic]. 2016 Feb 2/17/2016; PMID: 26891025, DOI: 10.1002/stem.2307, ISSN: 1549-4918.

Parang B, Barrett CW, Williams CS. AOM/DSS Model of Colitis-Associated Cancer. Methods Mol. Biol. 2016; 1422: 297-307. PMID: 27246042, DOI: 10.1007/978-1-4939-3603-8_26, ISSN: 1940-6029.

Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ. Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. J. Neurosci. 2015 Nov 11/18/2015; 35(46): 15326-38. PMID: 26586820, PMCID: PMC4649005, PII: 35/46/15326, DOI: 10.1523/JNEUROSCI.2724-15.2015, ISSN: 1529-2401.

Williams CS, Bernard JK, Demory Beckler M, Almohazey D, Washington MK, Smith JJ, Frey MR. ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis [print-electronic]. 2015 Jul; 36(7): 710-8. PMID: 25916654, PMCID: PMC4572918, PII: bgv049, DOI: 10.1093/carcin/bgv049, ISSN: 1460-2180.

Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J. Clin. Invest [print-electronic]. 2015 Jul 7/1/2015; 125(7): 2646-60. PMID: 26053663, PMCID: PMC4563672, PII: 76099, DOI: 10.1172/JCI76099, ISSN: 1558-8238.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Mar 3/15/2015; 308(6): G562-71. PMID: 25573176, PMCID: PMC4360050, PII: ajpgi.00253.2014, DOI: 10.1152/ajpgi.00253.2014, ISSN: 1522-1547.

Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J [print-electronic]. 2015 Mar; 29(3): 786-95. PMID: 25398765, PII: fj.14-254284, DOI: 10.1096/fj.14-254284, ISSN: 1530-6860.

Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J [print-electronic]. 2015 Mar; 29(3): 786-95. PMID: 25398765, PMCID: PMC4763883, PII: fj.14-254284, DOI: 10.1096/fj.14-254284, ISSN: 1530-6860.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288.

Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Aug 8/1/2013; 305(3): G225-40. PMID: 23703655, PMCID: PMC3742860, PII: ajpgi.00091.2013, DOI: 10.1152/ajpgi.00091.2013, ISSN: 1522-1547.

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606.

Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res [print-electronic]. 2013 Feb 2/1/2013; 73(3): 1245-55. PMID: 23221387, PMCID: PMC3563732, PII: 0008-5472.CAN-12-3150, DOI: 10.1158/0008-5472.CAN-12-3150, ISSN: 1538-7445.

Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS ONE. 2013; 8(12): e82300. PMID: 24367513, PMCID: PMC3867379, PII: PONE-D-13-38373, DOI: 10.1371/journal.pone.0082300, ISSN: 1932-6203.

Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS ONE [electronic-print]. 2013; 8(7): e67845. PMID: 23861820, PMCID: PMC3701622, PII: PONE-D-13-14817, DOI: 10.1371/journal.pone.0067845, ISSN: 1932-6203.

Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KT. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS ONE [print-electronic]. 2012; 7(3): e33546. PMID: 22428068, PMCID: PMC3299802, PII: PONE-D-12-00729, DOI: 10.1371/journal.pone.0033546, ISSN: 1932-6203.

Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS ONE [print-electronic]. 2012; 7(12): e51205. PMID: 23251453, PMCID: PMC3521008, PII: PONE-D-12-22965, DOI: 10.1371/journal.pone.0051205, ISSN: 1932-6203.

Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W, Beauchamp RD, Chang MS. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J. Clin. Invest [print-electronic]. 2011 Oct; 121(10): 4056-69. PMID: 21911938, PMCID: PMC3195453, PII: 44228, DOI: 10.1172/JCI44228, ISSN: 1558-8238.

Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res [print-electronic]. 2011 Feb 2/15/2011; 71(4): 1302-12. PMID: 21303973, PMCID: PMC3150168, PII: 0008-5472.CAN-10-3317, DOI: 10.1158/0008-5472.CAN-10-3317, ISSN: 1538-7445.

Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS. Bves modulates tight junction associated signaling. PLoS ONE. 2011; 6(1): e14563. PMID: 21283798, PMCID: PMC3024319, DOI: 10.1371/journal.pone.0014563, ISSN: 1932-6203.

Hong SK, Chaturvedi R, Piazuelo MB, Coburn LA, Williams CS, Delgado AG, Casero RA, Schwartz DA, Wilson KT. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Inflamm. Bowel Dis. 2010 Sep; 16(9): 1557-66. PMID: 20127992, PMCID: PMC2894261, DOI: 10.1002/ibd.21224, ISSN: 1536-4844.

Whittem CG, Williams AD, Williams CS. Murine Colitis modeling using Dextran Sulfate Sodium (DSS). J Vis Exp. 2010; (35): PMID: 20087313, PMCID: PMC2841571, PII: 1652, DOI: 10.3791/1652, ISSN: 1940-087X.

Farmer TE, Williams CS, Washington MK, Hiebert SW. Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity. J. Cell. Biochem. 2008 Aug 8/15/2008; 104(6): 2228-40. PMID: 18442038, PMCID: PMC3164503, DOI: 10.1002/jcb.21779, ISSN: 1097-4644.

Moore AC, Amann JM, Williams CS, Tahinci E, Farmer TE, Martinez JA, Yang G, Luce KS, Lee E, Hiebert SW. Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. Mol. Cell. Biol [print-electronic]. 2008 Feb; 28(3): 977-87. PMID: 18039847, PMCID: PMC2223385, PII: MCB.01242-07, DOI: 10.1128/MCB.01242-07, ISSN: 1098-5549.

Martinez JA, Williams CS, Amann JM, Ellis TC, Moreno-Miralles I, Washington MK, Gregoli P, Hiebert SW. Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis. Gastroenterology. 2006 Aug; 131(2): 579-88. PMID: 16890610, PII: S0016-5085(06)01238-8, DOI: 10.1053/j.gastro.2006.06.009, ISSN: 0016-5085.

Smith DS, Williams CS, Ferris CD. Diagnosis and treatment of chronic gastroparesis and chronic intestinal pseudo-obstruction. Gastroenterol. Clin. North Am. 2003 Jun; 32(2): 619-58. PMID: 12858609, ISSN: 0889-8553.

Aklog L, Williams CS, Byrne JG, Goldhaber SZ. Acute pulmonary embolectomy: a contemporary approach. Circulation. 2002 Mar 3/26/2002; 105(12): 1416-9. PMID: 11914247, ISSN: 1524-4539.

Williams CS, Sheng H, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG, DuBois RN. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia. 2001 Sep; 3(5): 428-36. PMID: 11687954, PMCID: PMC1506203, ISSN: 1522-8002.

Mann M, Sheng H, Shao J, Williams CS, Pisacane PI, Sliwkowski MX, DuBois RN. Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Gastroenterology. 2001 Jun; 120(7): 1713-9. PMID: 11375952, PII: S0016508501646870, ISSN: 0016-5085.

Williams CS, Watson AJ, Sheng H, Helou R, Shao J, DuBois RN. Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models. Cancer Res. 2000 Nov 11/1/2000; 60(21): 6045-51. PMID: 11085526, ISSN: 0008-5472.

Callejas NA, Boscá L, Williams CS, DuBOIS RN, Martín-Sanz P. Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins. Gastroenterology. 2000 Aug; 119(2): 493-501. PMID: 10930384, PII: S0016508500494680, ISSN: 0016-5085.

Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Invest. 2000 Jun; 105(11): 1589-94. PMID: 10841517, PMCID: PMC300858, DOI: 10.1172/JCI9621, ISSN: 0021-9738.

Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J. Biol. Chem. 2000 Mar 3/3/2000; 275(9): 6628-35. PMID: 10692471, ISSN: 0021-9258.

Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 1999 Dec 12/20/1999; 18(55): 7908-16. PMID: 10630643, DOI: 10.1038/sj.onc.1203286, ISSN: 0950-9232.

Williams CS, Goldman AP, Sheng H, Morrow JD, DuBois RN. Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth. Neoplasia. 1999 Jun; 1(2): 170-6. PMID: 10933052, PMCID: PMC1508136, ISSN: 1522-8002.

Williams CS, Shattuck-Brandt RL, DuBois RN. The role of COX-2 in intestinal cancer. Expert Opin Investig Drugs. 1999 Jan; 8(1): 1-12. PMID: 15992053, DOI: 10.1517/13543784.8.1.1, ISSN: 1744-7658.

Goldman AP, Williams CS, Sheng H, Lamps LW, Williams VP, Pairet M, Morrow JD, DuBois RN. Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis. 1998 Dec; 19(12): 2195-9. PMID: 9886578, ISSN: 0143-3334.

Sheng H, Williams CS, Shao J, Liang P, DuBois RN, Beauchamp RD. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J. Biol. Chem. 1998 Aug 8/21/1998; 273(34): 22120-7. PMID: 9705357, ISSN: 0021-9258.

Sheng H, Shao J, Williams CS, Pereira MA, Taketo MM, Oshima M, Reynolds AB, Washington MK, DuBois RN, Beauchamp RD. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis. 1998 Apr; 19(4): 543-9. PMID: 9600336, ISSN: 0143-3334.

Williams CS, Smalley W, DuBois RN. Aspirin use and potential mechanisms for colorectal cancer prevention. J. Clin. Invest. 1997 Sep 9/15/1997; 100(6): 1325-9. PMID: 9294096, PMCID: PMC508309, DOI: 10.1172/JCI119651, ISSN: 0021-9738.

Zhang T, Nanney LB, Peeler MO, Williams CS, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res. 1997 May 5/1/1997; 57(9): 1638-43. PMID: 9134999, ISSN: 0008-5472.

Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M, Cheng T, Ludwig EH, Sharma AM, Hata A, Jeunemaitre X, Lalouel JM. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J. Clin. Invest. 1997 Apr 4/1/1997; 99(7): 1786-97. PMID: 9120024, PMCID: PMC508000, DOI: 10.1172/JCI119343, ISSN: 0021-9738.

Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD, DuBois RN. Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology. 1996 Oct; 111(4): 1134-40. PMID: 8831610, PII: S0016-5085(96)70083-5, ISSN: 0016-5085.

DuBois RN, Eberhart CF, Williams CS. Introduction to eicosanoids and the gastroenteric tract. Gastroenterol. Clin. North Am. 1996 Jun; 25(2): 267-77. PMID: 9229572, ISSN: 0889-8553.

Williams CS, DuBois RN. Prostaglandin endoperoxide synthase: why two isoforms?. Am. J. Physiol. 1996 Mar; 270(3 Pt 1): G393-400. PMID: 8638704, ISSN: 0002-9513.

Hunt SC, Williams CS, Sharma AM, Inoue I, Williams RR, Lalouel JM. Lack of linkage between the endothelial nitric oxide synthase gene and hypertension. J Hum Hypertens. 1996 Jan; 10(1): 27-30. PMID: 8642187, ISSN: 0950-9240.

Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM. Molecular basis of human hypertension: role of angiotensinogen. Cell. 1992 Oct 10/2/1992; 71(1): 169-80. PMID: 1394429, PII: 0092-8674(92)90275-H, ISSN: 0092-8674.

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Posted: 2/24/2015
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