John G. Kuchtey, Ph.D.

Research Associate Professor

john.kuchtey@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Ophthalmology and Visual Sciences
Education
Ph.D., Pharmacology, Cornell University, Ithaca, New YorkB.A., Physics and Russian, Cornell University, Ithaca, New York
Office Address
11425C MRB IV
2213 Garland Ave.
Nashville, TN 37232
Research Keywords
Ophthalmology, Glaucoma, Genetics
Publications
Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Bailey JNC, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe SI, Kazama S, Zarnowski T, Inoue K, Irkec M, Coca-Prados M, Sugiyama K, Järvelä I, Schlottmann P, Lerner SF, Lamari H, Nilgün Y, Bikbov M, Park KH, Cha SC, Yamashiro K, Zenteno JC, Jonas JB, Kumar RS, Perera SA, Chan ASY, Kobakhidze N, George R, Vijaya L, Do T, Edward DP, de Juan Marcos L, Pakravan M, Moghimi S, Ideta R, Bach-Holm D, Kappelgaard P, Wirostko B, Thomas S, Gaston D, Bedard K, Greer WL, Yang Z, Chen X, Huang L, Sang J, Jia H, Jia L, Qiao C, Zhang H, Liu X, Zhao B, Wang YX, Xu L, Leruez S, Reynier P, Chichua G, Tabagari S, Uebe S, Zenkel M, Berner D, Mossböck G, Weisschuh N, Hoja U, Welge-Luessen UC, Mardin C, Founti P, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Ghosh A, Shetty R, Porporato N, Saravanan V, Venkatesh R, Shivkumar C, Kalpana N, Sarangapani S, Kanavi MR, Beni AN, Yazdani S, Lashay A, Naderifar H, Khatibi N, Fea A, Lavia C, Dallorto L, Rolle T, Frezzotti P, Paoli D, Salvi E, Manunta P, Mori Y, Miyata K, Higashide T, Chihara E, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Miyake M, Gotoh N, Matsuda F, Yoshimura N, Ikeda Y, Ueno M, Sotozono C, Jeoung JW, Sagong M, Park KH, Ahn J, Cruz-Aguilar M, Ezzouhairi SM, Rafei A, Chong YF, Ng XY, Goh SR, Chen Y, Yong VHK, Khan MI, Olawoye OO, Ashaye AO, Ugbede I, Onakoya A, Kizor-Akaraiwe N, Teekhasaenee C, Suwan Y, Supakontanasan W, Okeke S, Uche NJ, Asimadu I, Ayub H, Akhtar F, Kosior-Jarecka E, Lukasik U, Lischinsky I, Castro V, Grossmann RP, Megevand GS, Roy S, Dervan E, Silke E, Rao A, Sahay P, Fornero P, Cuello O, Sivori D, Zompa T, Mills RA, Souzeau E, Mitchell P, Wang JJ, Hewitt AW, Coote M, Crowston JG, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Kazakbaeva G, Fayzrakhmanov R, Al-Obeidan SA, Owaidhah O, Aljasim LA, Chowbay B, Foo JN, Soh RQ, Sim KS, Xie Z, Cheong AWO, Mok SQ, Soo HM, Chen XY, Peh SQ, Heng KK, Husain R, Ho SL, Hillmer AM, Cheng CY, Escudero-Domínguez FA, González-Sarmiento R, Martinon-Torres F, Salas A, Pathanapitoon K, Hansapinyo L, Wanichwecharugruang B, Kitnarong N, Sakuntabhai A, Nguyn HX, Nguyn GTT, Nguyn TV, Zenz W, Binder A, Klobassa DS, Hibberd ML, Davila S, Herms S, Nöthen MM, Moebus S, Rautenbach RM, Ziskind A, Carmichael TR, Ramsay M, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Cueto LF, Oguz Ç, Tamcelik N, Atalay E, Batu B, Aktas D, Kasim B, Wilson MR, Coleman AL, Liu Y, Challa P, Herndon L, Kuchtey RW, Kuchtey J, Curtin K, Chaya CJ, Crandall A, Zangwill LM, Wong TY, Nakano M, Kinoshita S, den Hollander AI, Vesti E, Fingert JH, Lee RK, Sit AJ, Shingleton BJ, Wang N, Cusi D, Qamar R, Kraft P, Pericak-Vance MA, Raychaudhuri S, Heegaard S, Kivelä T, Reis A, Kruse FE, Weinreb RN, Pasquale LR, Haines JL, Thorsteinsdottir U, Jonasson F, Allingham RR, Milea D, Ritch R, Kubota T, Tashiro K, Vithana EN, Micheal S, Topouzis F, Craig JE, Dubina M, Sundaresan P, Stefansson K, Wiggs JL, Pasutto F, Khor CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat. Genet [print-electronic]. 2017 May 5/29/2017; PMID: 28553957, PII: ng.3875, DOI: 10.1038/ng.3875, ISSN: 1546-1718.

Liu Y, Bailey JC, Helwa I, Dismuke WM, Cai J, Drewry M, Brilliant MH, Budenz DL, Christen WG, Chasman DI, Fingert JH, Gaasterland D, Gaasterland T, Gordon MO, Igo RP, Kang JH, Kass MA, Kraft P, Lee RK, Lichter P, Moroi SE, Realini A, Richards JE, Ritch R, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Vollrath D, Weinreb R, Medeiros F, Wollstein G, Zack DJ, Zhang K, Pericak-Vance MA, Gonzalez P, Stamer WD, Kuchtey J, Kuchtey RW, Allingham RR, Hauser MA, Pasquale LR, Haines JL, Wiggs JL. A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. Invest. Ophthalmol. Vis. Sci. 2016 Aug 8/1/2016; 57(10): 3974-81. PMID: 27537254, PII: 2543658, DOI: 10.1167/iovs.16-19688, ISSN: 1552-5783.

Kuchtey RW, Naratadam GT, Kuchtey J. Severe open angle glaucoma in hereditary hemorrhagic telangiectasia. Clin Case Rep [print-electronic]. 2015 Sep; 3(9): 725-7. PMID: 26401274, PMCID: PMC4574785, DOI: 10.1002/ccr3.324, ISSN: 2050-0904.

Burgess LG, Uppal K, Walker DI, Roberson RM, Tran V, Parks MB, Wade EA, May AT, Umfress AC, Jarrell KL, Stanley BO, Kuchtey J, Kuchtey RW, Jones DP, Brantley MA. Metabolome-Wide Association Study of Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015 Jul; 56(8): 5020-8. PMID: 26230767, PMCID: PMC4525636, PII: 2422884, DOI: 10.1167/iovs.15-16702, ISSN: 1552-5783.

Kuchtey J, Kunkel J, Burgess LG, Parks MB, Brantley MA, Kuchtey RW. Elevated transforming growth factor ß1 in plasma of primary open-angle glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2014 Aug; 55(8): 5291-7. PMID: 25061114, PMCID: PMC4142830, PII: iovs.14-14578, DOI: 10.1167/iovs.14-14578, ISSN: 1552-5783.

Kuchtey J, Kuchtey RW. The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure. J Ocul Pharmacol Ther [print-electronic]. 2014 Mar; 30(2-3): 170-80. PMID: 24521159, PMCID: PMC3991966, DOI: 10.1089/jop.2013.0184, ISSN: 1557-7732.

Kuchtey J, Chowdhury UR, Uptegraft CC, Fautsch MP, Kuchtey RW. A de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor. Eur J Med Genet [print-electronic]. 2013 Jun; 56(6): 292-6. PMID: 23517641, PMCID: PMC3672363, PII: S1769-7212(13)00062-1, DOI: 10.1016/j.ejmg.2013.03.002, ISSN: 1878-0849.

Kuchtey J, Chang TC, Panagis L, Kuchtey RW. Marfan syndrome caused by a novel FBN1 mutation with associated pigmentary glaucoma. Am. J. Med. Genet. A [print-electronic]. 2013 Apr; 161A(4): 880-3. PMID: 23444230, PMCID: PMC3638319, DOI: 10.1002/ajmg.a.35838, ISSN: 1552-4833.

Kuchtey J, Kunkel J, Esson D, Sapienza JS, Ward DA, Plummer CE, Gelatt KN, Kuchtey RW. Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles. Invest. Ophthalmol. Vis. Sci. 2013 Mar; 54(3): 1881-6. PMID: 23422823, PMCID: PMC3604907, PII: iovs.12-10796, DOI: 10.1167/iovs.12-10796, ISSN: 1552-5783.

Kuchtey J, Olson LM, Rinkoski T, Mackay EO, Iverson TM, Gelatt KN, Haines JL, Kuchtey RW. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet [print-electronic]. 2011 Feb; 7(2): e1001306. PMID: 21379321, PMCID: PMC3040645, DOI: 10.1371/journal.pgen.1001306, ISSN: 1553-7404.

Kuchtey J, Rezaei KA, Jaru-Ampornpan P, Sternberg P, Kuchtey RW. Multiplex cytokine analysis reveals elevated concentration of interleukin-8 in glaucomatous aqueous humor. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Dec; 51(12): 6441-7. PMID: 20592224, PMCID: PMC3055764, PII: iovs.10-5216, DOI: 10.1167/iovs.10-5216, ISSN: 1552-5783.

Liu YC, Gray RC, Hardy GA, Kuchtey J, Abbott DW, Emancipator SN, Harding CV. CpG-B oligodeoxynucleotides inhibit TLR-dependent and -independent induction of type I IFN in dendritic cells. J. Immunol [print-electronic]. 2010 Apr 4/1/2010; 184(7): 3367-76. PMID: 20181884, PMCID: PMC2892962, PII: jimmunol.0903079, DOI: 10.4049/jimmunol.0903079, ISSN: 1550-6606.

Jaru-Ampornpan P, Kuchtey J, Dev VG, Kuchtey R. Primary congenital glaucoma associated with Patau syndrome with long survival. J Pediatr Ophthalmol Strabismus. 2010; 47 Online: e1-4. PMID: 21080618, DOI: 10.3928/01913913-20100618-09, ISSN: 1938-2405.

Kuchtey J, Källberg ME, Gelatt KN, Rinkoski T, Komàromy AM, Kuchtey RW. Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2008 Aug; 49(8): 3438-48. PMID: 18421092, PMCID: PMC2814173, PII: iovs.07-1347, DOI: 10.1167/iovs.07-1347, ISSN: 1552-5783.

Gray RC, Kuchtey J, Harding CV. CpG-B ODNs potently induce low levels of IFN-alphabeta and induce IFN-alphabeta-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs. J. Leukoc. Biol [print-electronic]. 2007 Apr; 81(4): 1075-85. PMID: 17227820, PII: jlb.1006606, DOI: 10.1189/jlb.1006606, ISSN: 0741-5400.

Kuchtey J, Fulton SA, Reba SM, Harding CV, Boom WH. Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guérin infection. Immunology. 2006 May; 118(1): 39-49. PMID: 16630021, PMCID: PMC1782276, PII: IMM2337, DOI: 10.1111/j.1365-2567.2006.02337.x, ISSN: 0019-2805.

Kuchtey J, Chefalo PJ, Gray RC, Ramachandra L, Harding CV. Enhancement of dendritic cell antigen cross-presentation by CpG DNA involves type I IFN and stabilization of class I MHC mRNA. J. Immunol. 2005 Aug 8/15/2005; 175(4): 2244-51. PMID: 16081792, PII: 175/4/2244, ISSN: 0022-1767.

Kuchtey J, Pennini M, Pai RK, Harding CV. CpG DNA induces a class II transactivator-independent increase in class II MHC by stabilizing class II MHC mRNA in B lymphocytes. J. Immunol. 2003 Sep 9/1/2003; 171(5): 2320-5. PMID: 12928377, ISSN: 0022-1767.

Kuchtey J, Fewtrell C. Protein kinase C activator PMA reduces the Ca(2+) response to antigen stimulation of adherent RBL-2H3 mucosal mast cells by inhibiting depletion of intracellular Ca(2+) stores. J. Cell. Physiol. 1999 Oct; 181(1): 113-23. PMID: 10457359, PII: 10.1002/(SICI)1097-4652(199910)181:1<113::AID-JCP12>3.0.CO;2-7, DOI: 10.1002/(SICI)1097-4652(199910)181:1<113::AID-JCP12>3.0.CO;2-7, ISSN: 0021-9541.

Kim TD, Eddlestone GT, Mahmoud SF, Kuchtey J, Fewtrell C. Correlating Ca2+ responses and secretion in individual RBL-2H3 mucosal mast cells. J. Biol. Chem. 1997 Dec 12/12/1997; 272(50): 31225-9. PMID: 9395446, ISSN: 0021-9258.

Kuchtey J, Fewtrell C. Subcloning the RBL-2H3 mucosal mast cell line reduces Ca2+ response heterogeneity at the single-cell level. J. Cell. Physiol. 1996 Mar; 166(3): 643-52. PMID: 8600169, PII: 10.1002/(SICI)1097-4652(199603)166:3<643::AID-JCP20>3.0.CO;2-6, DOI: 10.1002/(SICI)1097-4652(199603)166:3<643::AID-JCP20>3.0.CO;2-6, ISSN: 0021-9541.