Zixiu Xiang, Ph.D.

Research Assistant Professor

Faculty Appointments
Research Assistant Professor of Pharmacology
Ph.D., Psychobiology, Yale University, New Haven, ConnecticutM.S., Neurophysiology, Fudan University, Shanghai, ChinaB.S., Biology, Fudan University, Shanghai, China
Office Address
12480 MRBIV
Nashville, TN 8548
Research Keywords
Neuroscience, physiology, pharmacology, receptor, synaptic transmission and plasticity
Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW, Niswender CM, Xiang Z, Conn PJ. A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Mol. Pharmacol [print-electronic]. 2013 Apr; 83(4): 835-47. PMID: 23348500, PMCID: PMC3608436, PII: mol.112.082891, DOI: 10.1124/mol.112.082891, ISSN: 1521-0111.

Rook JM, Noetzel MJ, Pouliot WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol. Psychiatry [print-electronic]. 2013 Mar 3/15/2013; 73(6): 501-9. PMID: 23140665, PMCID: PMC3572342, PII: S0006-3223(12)00806-2, DOI: 10.1016/j.biopsych.2012.09.012, ISSN: 1873-2402.

Tarr JC, Turlington ML, Reid PR, Utley TJ, Sheffler DJ, Cho HP, Klar R, Pancani T, Klein MT, Bridges TM, Morrison RD, Blobaum AL, Xiang Z, Daniels JS, Niswender CM, Conn PJ, Wood MR, Lindsley CW. Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169. ACS Chem Neurosci [print-electronic]. 2012 Nov 11/21/2012; 3(11): 884-95. PMID: 23173069, PMCID: PMC3503349, DOI: 10.1021/cn300068s, ISSN: 1948-7193.

Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. J. Neurosci. 2012 Jun 6/20/2012; 32(25): 8532-44. PMID: 22723693, PMCID: PMC3398407, PII: 32/25/8532, DOI: 10.1523/JNEUROSCI.0337-12.2012, ISSN: 1529-2401.

Xiang Z, Thompson AD, Jones CK, Lindsley CW, Conn PJ. Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease. J. Pharmacol. Exp. Ther [print-electronic]. 2012 Mar; 340(3): 595-603. PMID: 22135383, PMCID: PMC3286317, PII: jpet.111.187856, DOI: 10.1124/jpet.111.187856, ISSN: 1521-0103.

Noetzel MJ, Rook JM, Vinson PN, Cho HP, Days E, Zhou Y, Rodriguez AL, Lavreysen H, Stauffer SR, Niswender CM, Xiang Z, Daniels JS, Jones CK, Lindsley CW, Weaver CD, Conn PJ. Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol. Pharmacol [print-electronic]. 2012 Feb; 81(2): 120-33. PMID: 22021324, PMCID: PMC3263948, PII: mol.111.075184, DOI: 10.1124/mol.111.075184, ISSN: 1521-0111.

Xiang ZL, Erasmus J, Komaki R, Cox JD, Chang JY. FDG uptake correlates with recurrence and survival after treatment of unresectable stage III non-small cell lung cancer with high-dose proton therapy and chemotherapy. Radiat Oncol. 2012; 7: 144. PMID: 22929048, PMCID: PMC3444399, PII: 1748-717X-7-144, DOI: 10.1186/1748-717X-7-144, ISSN: 1748-717X.

Xiang Z, Thompson AD, Brogan JT, Schulte ML, Melancon BJ, Mi D, Lewis LM, Zou B, Yang L, Morrison R, Santomango T, Byers F, Brewer K, Aldrich JS, Yu H, Dawson ES, Li M, McManus O, Jones CK, Daniels JS, Hopkins CR, Xie XS, Conn PJ, Weaver CD, Lindsley CW. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Dec 12/21/2011; 2(12): 730-42. PMID: 22368764, PMCID: PMC3285241, DOI: 10.1021/cn200090z, ISSN: 1948-7193.

Lebois EP, Digby GJ, Sheffler DJ, Melancon BJ, Tarr JC, Cho HP, Miller NR, Morrison R, Bridges TM, Xiang Z, Daniels JS, Wood MR, Conn PJ, Lindsley CW. Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorg. Med. Chem. Lett [print-electronic]. 2011 Nov 11/1/2011; 21(21): 6451-5. PMID: 21930376, PMCID: PMC3190051, PII: S0960-894X(11)01183-8, DOI: 10.1016/j.bmcl.2011.08.084, ISSN: 1464-3405.

Johnson KA, Niswender CM, Conn PJ, Xiang Z. Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata. Neurosci. Lett [print-electronic]. 2011 Oct 10/24/2011; 504(2): 102-6. PMID: 21945652, PMCID: PMC3556513, PII: S0304-3940(11)01272-9, DOI: 10.1016/j.neulet.2011.09.007, ISSN: 1872-7972.

Lebois EP, Bridges TM, Lewis LM, Dawson ES, Kane AS, Xiang Z, Jadhav SB, Yin H, Kennedy JP, Meiler J, Niswender CM, Jones CK, Conn PJ, Weaver CD, Lindsley CW. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS Chem Neurosci. 2010; 1(2): 104-21. PMID: 21961051, PMCID: PMC3180826, DOI: 10.1021/cn900003h, ISSN: 1948-7193.

Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J. Neurosci. 2009 Nov 11/11/2009; 29(45): 14271-86. PMID: 19906975, PMCID: PMC2811323, PII: 29/45/14271, DOI: 10.1523/JNEUROSCI.3930-09.2009, ISSN: 1529-2401.

Sheffler DJ, Williams R, Bridges TM, Xiang Z, Kane AS, Byun NE, Jadhav S, Mock MM, Zheng F, Lewis LM, Jones CK, Niswender CM, Weaver CD, Lindsley CW, Conn PJ. A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol. Pharmacol [print-electronic]. 2009 Aug; 76(2): 356-68. PMID: 19407080, PMCID: PMC2713127, PII: mol.109.056531, DOI: 10.1124/mol.109.056531, ISSN: 1521-0111.

Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL, Xiang Z, Zhang Y, Jones PJ, Lindsley CW, Olive MF, Conn PJ. MGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology [print-electronic]. 2009 Aug; 34(9): 2057-71. PMID: 19295507, PMCID: PMC2884290, PII: npp200930, DOI: 10.1038/npp.2009.30, ISSN: 1740-634X.

Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol. Pharmacol [print-electronic]. 2008 Nov; 74(5): 1345-58. PMID: 18664603, PMCID: PMC2574552, PII: mol.108.049551, DOI: 10.1124/mol.108.049551, ISSN: 1521-0111.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J. Neurosci. 2008 Oct 10/8/2008; 28(41): 10422-33. PMID: 18842902, PMCID: PMC2577155, PII: 28/41/10422, DOI: 10.1523/JNEUROSCI.1850-08.2008, ISSN: 1529-2401.

Jones PJ, Xiang Z, Conn PJ. Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse. Neuropharmacology [print-electronic]. 2008 Sep; 55(4): 440-6. PMID: 18625254, PMCID: PMC2644556, PII: S0028-3908(08)00238-4, DOI: 10.1016/j.neuropharm.2008.06.043, ISSN: 0028-3908.

Wang L, Kitai ST, Xiang Z. Activity-dependent bidirectional modification of inhibitory synaptic transmission in rat subthalamic neurons. J. Neurosci. 2006 Jul 7/12/2006; 26(28): 7321-7. PMID: 16837578, PII: 26/28/7321, DOI: 10.1523/JNEUROSCI.4656-05.2006, ISSN: 1529-2401.

Wang L, Kitai ST, Xiang Z. Modulation of excitatory synaptic transmission by endogenous glutamate acting on presynaptic group II mGluRs in rat substantia nigra compacta. J. Neurosci. Res. 2005 Dec 12/15/2005; 82(6): 778-87. PMID: 16273546, DOI: 10.1002/jnr.20694, ISSN: 0360-4012.

Xiang Z, Wang L, Kitai ST. Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J. Neurophysiol. 2005 Mar; 93(3): 1145-57. PMID: 15738272, PII: 93/3/1145, DOI: 10.1152/jn.00561.2004, ISSN: 0022-3077.

Duntsch CD, Zhou Q, Jayakar HR, Weimar JD, Robertson JH, Pfeffer LM, Wang L, Xiang Z, Whitt MA. Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model. J. Neurosurg. 2004 Jun; 100(6): 1049-59. PMID: 15200120, DOI: 10.3171/jns.2004.100.6.1049, ISSN: 0022-3085.

Xiang Z, Prince DA. Heterogeneous actions of serotonin on interneurons in rat visual cortex. J. Neurophysiol. 2003 Mar; 89(3): 1278-87. PMID: 12626611, PII: 89/3/1278, DOI: 10.1152/jn.00533.2002, ISSN: 0022-3077.

Xiang Z, Huguenard JR, Prince DA. Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex. J. Neurophysiol. 2002 Aug; 88(2): 740-50. PMID: 12163526, ISSN: 0022-3077.

Xiang Z, Huguenard JR, Prince DA. Cholinergic switching within neocortical inhibitory networks. Science. 1998 Aug 8/14/1998; 281(5379): 985-8. PMID: 9703513, ISSN: 0036-8075.

Xiang Z, Brown TH. Complex synaptic current waveforms evoked in hippocampal pyramidal neurons by extracellular stimulation of dentate gyrus. J. Neurophysiol. 1998 May; 79(5): 2475-84. PMID: 9582221, ISSN: 0022-3077.

Xiang Z, Huguenard JR, Prince DA. GABAA receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex. J. Physiol. (Lond.). 1998 Feb 2/1/1998; 506 ( Pt 3): 715-30. PMID: 9503333, PMCID: PMC2230760, ISSN: 0022-3751.

Xiang Z, Greenwood AC, Kairiss EW, Brown TH. Quantal mechanism of long-term potentiation in hippocampal mossy-fiber synapses. J. Neurophysiol. 1994 Jun; 71(6): 2552-6. PMID: 7931534, ISSN: 0022-3077.

Claiborne BJ, Xiang Z, Brown TH. Hippocampal circuitry complicates analysis of long-term potentiation in mossy fiber synapses. Hippocampus. 1993 Apr; 3(2): 115-21. PMID: 8353597, DOI: 10.1002/hipo.450030202, ISSN: 1050-9631.