Jonathan C. Nesbitt, M.D.


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Faculty Appointments
Interim Chair of the Department of Thoracic Surgery Professor of Thoracic Surgery
M.D., MEDICINE, Georgetown University, Washington, District of ColumbiaB.A., University of Virginia, Charlottesville, Virginia
Office Address
609 Oxford House
1313 21st Avenue North
Nashville, TN 37232-4682
Deppen SA, Blume JD, Aldrich MC, Fletcher SA, Massion PP, Walker RC, Chen HC, Speroff T, Degesys CA, Pinkerman R, Lambright ES, Nesbitt JC, Putnam JB, Grogan EL. Predicting lung cancer prior to surgical resection in patients with lung nodules. J Thorac Oncol. 2014 Oct; 9(10): 1477-84. PMID: 25170644, PMCID: PMC4272613, PII: S1556-0864(15)30704-8, DOI: 10.1097/JTO.0000000000000287, ISSN: 1556-1380.

Macfie RC, Webel AD, Nesbitt JC, Fann JI, Hicks GL, Feins RH. "Boot camp" simulator training in open hilar dissection in early cardiothoracic surgical residency. Ann. Thorac. Surg [print-electronic]. 2014 Jan; 97(1): 161-6. PMID: 24090574, PII: S0003-4975(13)01685-8, DOI: 10.1016/j.athoracsur.2013.07.074, ISSN: 1552-6259.

Nesbitt JC, St Julien J, Absi TS, Ahmad RM, Grogan EL, Balaguer JM, Lambright ES, Deppen SA, Wu H, Putnam JB. Tissue-based coronary surgery simulation: medical student deliberate practice can achieve equivalency to senior surgery residents. J. Thorac. Cardiovasc. Surg [print-electronic]. 2013 Jun; 145(6): 1453-8; discussion 1458. PMID: 23499474, PII: S0022-5223(13)00203-1, DOI: 10.1016/j.jtcvs.2013.02.048, ISSN: 1097-685X.

St Julien JB, Aldrich MC, Sheng S, Deppen SA, Burfeind WR, Putnam JB, Lambright ES, Nesbitt JC, Grogan EL. Obesity increases operating room time for lobectomy in the society of thoracic surgeons database. Ann. Thorac. Surg [print-electronic]. 2012 Dec; 94(6): 1841-7. PMID: 23040822, PMCID: PMC3748581, PII: S0003-4975(12)01766-3, DOI: 10.1016/j.athoracsur.2012.08.006, ISSN: 1552-6259.

St Julien JB, Pinkerman R, Aldrich MC, Chen H, Deppen SA, Callaway-Lane C, Massion P, Putnam JB, Lambright ES, Nesbitt JC, Grogan EL. Poor survival for veterans with pathologic stage I non-small-cell lung cancer. Am. J. Surg [print-electronic]. 2012 Nov; 204(5): 637-42. PMID: 22906246, PMCID: PMC3766956, PII: S0002-9610(12)00354-6, DOI: 10.1016/j.amjsurg.2012.07.008, ISSN: 1879-1883.

Nesbitt JC, Deppen S, Corcoran R, Cogdill S, Huckabay S, McKnight D, Osborne BF, Werking K, Gardner M, Perrigo L. Postoperative ambulation in thoracic surgery patients: standard versus modern ambulation methods. Nurs Crit Care [print-electronic]. 2012 May; 17(3): 130-7. PMID: 22497917, DOI: 10.1111/j.1478-5153.2011.00480.x, ISSN: 1478-5153.

Grogan EL, Weinstein JJ, Deppen SA, Putnam JB, Nesbitt JC, Lambright ES, Walker RC, Dittus RS, Massion PP. Thoracic operations for pulmonary nodules are frequently not futile in patients with benign disease. J Thorac Oncol. 2011 Oct; 6(10): 1720-5. PMID: 21760552, PMCID: PMC3712870, PII: S1556-0864(15)33211-1, DOI: 10.1097/JTO.0b013e318226b48a, ISSN: 1556-1380.

Deppen S, Putnam JB, Andrade G, Speroff T, Nesbitt JC, Lambright ES, Massion PP, Walker R, Grogan EL. Accuracy of FDG-PET to diagnose lung cancer in a region of endemic granulomatous disease. Ann. Thorac. Surg [print-electronic]. 2011 Aug; 92(2): 428-32; discussion 433. PMID: 21592456, PMCID: PMC3186439, PII: S0003-4975(11)00478-4, DOI: 10.1016/j.athoracsur.2011.02.052, ISSN: 1552-6259.

St Julien J, Putnam JB, Nesbitt JC, Lambright ES, Petracek MR, Grogan EL. Successful treatment of atrioesophageal fistula by cervical esophageal ligation and decompression. Ann. Thorac. Surg. 2011 Jun; 91(6): e85-6. PMID: 21619954, PMCID: PMC4154501, PII: S0003-4975(11)00207-4, DOI: 10.1016/j.athoracsur.2011.01.039, ISSN: 1552-6259.

Isbell JM, Deppen S, Putnam JB, Nesbitt JC, Lambright ES, Dawes A, Massion PP, Speroff T, Jones DR, Grogan EL. Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation. Ann. Thorac. Surg. 2011 Jan; 91(1): 227-33; discussion 233. PMID: 21172518, PMCID: PMC3748597, PII: S0003-4975(10)01933-8, DOI: 10.1016/j.athoracsur.2010.08.054, ISSN: 1552-6259.

Grogan EL, Deppen S, Pecot CV, Putnam JB, Nesbitt JC, Shyr Y, Rajanbabu R, Ory B, Lambright ES, Massion PP. Diagnostic characteristics of a serum biomarker in patients with positron emission tomography scans. Ann. Thorac. Surg. 2010 Jun; 89(6): 1724-8; discussion 1728. PMID: 20494018, PMCID: PMC3026702, PII: S0003-4975(10)00602-8, DOI: 10.1016/j.athoracsur.2010.03.008, ISSN: 1552-6259.

Dube JA, Barth MM, Cmiel CA, Cutshall SM, Olson SM, Sulla SJ, Nesbitt JC, Sobczak SC, Holland DE. Environmental noise sources and interventions to minimize them: a tale of 2 hospitals. J Nurs Care Qual. 2008 Jul; 23(3): 216-24; quiz 225. PMID: 18562863, PII: 00001786-200807000-00007, DOI: 10.1097/01.NCQ.0000324585.68966.51, ISSN: 1057-3631.

Nesbitt JC. Invited commentary. Ann. Thorac. Surg. 2006 Feb; 81(2): 472-3. PMID: 16427834, PII: S0003-4975(05)01766-2, DOI: 10.1016/j.athoracsur.2005.09.053, ISSN: 1552-6259.

Lee YC, Knight DA, Lane KB, Cheng DS, Koay MA, Teixeira LR, Nesbitt JC, Chambers RC, Thompson PJ, Light RW. Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2005 Apr; 288(4): L734-40. PMID: 15591415, PII: 00173.2004, DOI: 10.1152/ajplung.00173.2004, ISSN: 1040-0605.

Yamagata N, Shyr Y, Yanagisawa K, Edgerton M, Dang TP, Gonzalez A, Nadaf S, Larsen P, Roberts JR, Nesbitt JC, Jensen R, Levy S, Moore JH, Minna JD, Carbone DP. A training-testing approach to the molecular classification of resected non-small cell lung cancer. Clin. Cancer Res. 2003 Oct 10/15/2003; 9(13): 4695-704. PMID: 14581339, ISSN: 1078-0432.

Swisher SG, Ajani JA, Komaki R, Nesbitt JC, Correa AM, Cox JD, Lahoti S, Martin F, Putnam JB, Smythe WR, Vaporciyan AA, Walsh GL, Roth JA. Long-term outcome of phase II trial evaluating chemotherapy, chemoradiotherapy, and surgery for locoregionally advanced esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2003 Sep 9/1/2003; 57(1): 120-7. PMID: 12909224, PII: S0360301603005224, ISSN: 0360-3016.

Light RW, Rogers JT, Moyers JP, Lee YC, Rodriguez RM, Alford WC, Ball SK, Burrus GR, Coltharp WH, Glassford DM, Hoff SJ, Lea JW, Nesbitt JC, Petracek MR, Starkey TD, Stoney WS, Tedder M. Prevalence and clinical course of pleural effusions at 30 days after coronary artery and cardiac surgery. Am. J. Respir. Crit. Care Med [print-electronic]. 2002 Dec 12/15/2002; 166(12 Pt 1): 1567-71. PMID: 12406850, PII: 200203-184OC, DOI: 10.1164/rccm.200203-184OC, ISSN: 1073-449X.

Vaporciyan AA, Merriman KW, Ece F, Roth JA, Smythe WR, Swisher SG, Walsh GL, Nesbitt JC, Putnam JB. Incidence of major pulmonary morbidity after pneumonectomy: association with timing of smoking cessation. Ann. Thorac. Surg. 2002 Feb; 73(2): 420-5; discussion 425. PMID: 11845853, ISSN: 0003-4975.

Lee YC, Vaz MA, Ely KA, McDonald EC, Thompson PJ, Nesbitt JC, Light RW. Symptomatic persistent post-coronary artery bypass graft pleural effusions requiring operative treatment : clinical and histologic features. Chest. 2001 Mar; 119(3): 795-800. PMID: 11243959, ISSN: 0012-3692.

Wudel LJ, Nesbitt JC. Superior vena cava syndrome. Curr Treat Options Oncol. 2001 Feb; 2(1): 77-91. PMID: 12057143, ISSN: 1527-2729.

Munden RF, Nesbitt JC, Kemp BL, Chasen MH, Whitman GJ. Primary liposarcoma of the mediastinum. AJR Am J Roentgenol. 2000 Nov; 175(5): 1340. PMID: 11044037, DOI: 10.2214/ajr.175.5.1751340, ISSN: 0361-803X.

Yen N, Ioannides CG, Xu K, Swisher SG, Lawrence DD, Kemp BL, El-Naggar AK, Cristiano RJ, Fang B, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Merritt JA, Mukhopadhyay T, Nesbitt JC, Nguyen D, Perez-Soler R, Pisters KM, Putnam JB, Schrump DS, Shin DM, Walsh GL, Roth JA. Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type. P53 (Ad-p53). Cancer Gene Ther. 2000 Apr; 7(4): 530-6. PMID: 10811470, DOI: 10.1038/sj.cgt.7700138, ISSN: 0929-1903.

Zorn GL, Nesbitt JC. Surgical management of early stage lung cancer. Semin Surg Oncol. 2000 Mar; 18(2): 124-36. PMID: 10657914, PII: 10.1002/(SICI)1098-2388(200003)18:2<124::AID-SSU6>3.0.CO;2-N, ISSN: 8756-0437.

Walsh GL, Taylor GD, Nesbitt JC, Amato RJ. Intensive chemotherapy and radical resections for primary nonseminomatous mediastinal germ cell tumors. Ann. Thorac. Surg. 2000 Feb; 69(2): 337-43; discussion 343. PMID: 10735660, PII: S0003-4975(99)01472-1, ISSN: 0003-4975.

Nemunaitis J, Swisher SG, Timmons T, Connors D, Mack M, Doerksen L, Weill D, Wait J, Lawrence DD, Kemp BL, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Richli WR, Shin DM, Walsh GL, Merritt J, Roth J. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J. Clin. Oncol. 2000 Feb; 18(3): 609-22. PMID: 10653876, ISSN: 0732-183X.

Rolston KVI, Nesbitt JC, Walsh GL, Putnam JB, Teng R, Dogolo L, Vincent J, Bodey GP.. The penetration of trovafloxacin into lung tissue, skin, subcutaneous tissue, skeletal muscle, and bone in patients undergoing thoracotomy. Clin Pulm Med, Williams & Wilkins. 2000.

Ajani JA, Komaki R, Putnam JB, Wash G, Nesbitt JC, Pisters PW, Lynch PM, Vaporcian A, Smythe R, Lahoti S, Raijman I, Swisher S, Martin FD, Roth JA.. A three-step preoperative strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus. J Clinic Oncol. 2000.

Gandhi S, Walsh GL, Komaki R, Gokaslan ZL, Nesbitt JC, Putnam JB, Roth JA, Merriman KW, McCutcheon IE, Munden RF, Swisher SG. A multidisciplinary surgical approach to superior sulcus tumors with vertebral invasion. Ann. Thorac. Surg. 1999 Nov; 68(5): 1778-84; discussion 1784. PMID: 10585058, PII: S0003-4975(99)01068-1, ISSN: 0003-4975.

Swisher SG, Roth JA, Nemunaitis J, Lawrence DD, Kemp BL, Carrasco CH, Connors DG, El-Naggar AK, Fossella F, Glisson BS, Hong WK, Khuri FR, Kurie JM, Lee JJ, Lee JS, Mack M, Merritt JA, Nguyen DM, Nesbitt JC, Perez-Soler R, Pisters KM, Putnam JB, Richli WR, Savin M, Schrump DS, Shin DM, Shulkin A, Walsh GL, Wait J, Weill D, Waugh MK. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J. Natl. Cancer Inst. 1999 May 5/5/1999; 91(9): 763-71. PMID: 10328106, ISSN: 0027-8874.

Roth JA, Swisher SG, Merritt JA, Lawrence DD, Kemp BL, Carrasco CH, El-Naggar AK, Fossella FV, Glisson BS, Hong WK, Khurl FR, Kurie JM, Nesbitt JC, Pisters K, Putnam JB, Schrump DS, Shin DM, Walsh GL. Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacement. Semin. Oncol. 1998 Jun; 25(3 Suppl 8): 33-7. PMID: 9704675, ISSN: 0093-7754.

Shaw GL, Falk RT, Frame JN, Weiffenbach B, Nesbitt JC, Pass HI, Caporaso NE, Moir DT, Tucker MA. Genetic polymorphism of CYP2D6 and lung cancer risk. Cancer Epidemiol. Biomarkers Prev. 1998 Mar; 7(3): 215-9. PMID: 9521436, ISSN: 1055-9965.

Shin DM, Walsh GL, Komaki R, Putnam JB, Nesbitt JC, Ro JY, Shin JUC, Ki KH, Wimberly A, Pisters KMW, Schrump DS, Gregurich MA, Cox JD, Roth JA, Hong WK. Multidiciplinary approach to therapy for unresectable malignant thymoma. Ann Int Med. 1998; 129((2)): 100-4.

Walsh GL, Gokaslan ZL, McCutcheon IE, Mineo MT, Yasko AW, Swisher SG, Schrump DS, Nesbitt JC, Putnam JB, Roth JA. Anterior approaches to the thoracic spine in patients with cancer: indications and results. Ann. Thorac. Surg. 1997 Dec; 64(6): 1611-8. PMID: 9436544, PII: S0003497597010345, ISSN: 0003-4975.

Slaton JW, Balbay MD, Levy DA, Pisters LL, Nesbitt JC, Swanson DA, Dinney CP. Nephrectomy and vena caval thrombectomy in patients with metastatic renal cell carcinoma. Urology. 1997 Nov; 50(5): 673-7. PMID: 9372873, PII: S0090429597003294, ISSN: 0090-4295.

Nesbitt JC, Soltero ER, Dinney CP, Walsh GL, Schrump DS, Swanson DA, Pisters LL, Willis KD, Putnam JB. Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus. Ann. Thorac. Surg. 1997 Jun; 63(6): 1592-600. PMID: 9205155, PII: S0003497597003299, ISSN: 0003-4975.

Ferson DZ, Nesbitt JC, Nesbitt K, Walsh GL, Putnam JB, Schrump DS, Johansen MJ, Jones RL, Roth JA. The laryngeal mask airway: a new standard for airway evaluation in thoracic surgery. Ann. Thorac. Surg. 1997 Mar; 63(3): 768-72. PMID: 9066399, PII: S0003497597000076, ISSN: 0003-4975.

Roth JA, Nguyen D, Lawrence DD, Kemp BL, Carrasco CH, Ferson DZ, Hong WK, Komaki R, Lee JJ, Nesbitt JC, Pisters KM, Putnam JB, Schea R, Shin DM, Walsh GL, Dolormente MM, Han CI, Martin FD, Yen N, Xu K, Stephens LC, McDonnell TJ, Mukhopadhyay T, Cai D. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat. Med. 1996 Sep; 2(9): 985-91. PMID: 8782455, ISSN: 1078-8956.

Lee HY, Dawson MI, Walsh GL, Nesbitt JC, Eckert RL, Fuchs E, Hong WK, Lotan R, Kurie JM. Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells. Cell Growth Differ. 1996 Aug; 7(8): 997-1004. PMID: 8853895, ISSN: 1044-9523.

Nesbitt JC, Vega DM, Burke T, Mackay B. Cellular schwannoma of the bronchus. Ultrastruct Pathol. 1996 Jul; 20(4): 349-54. PMID: 8837342, ISSN: 0191-3123.

Nesbitt JC, Carrasco H. Expandable stents. Chest Surg. Clin. N. Am. 1996 May; 6(2): 305-28. PMID: 8724281, ISSN: 1052-3359.

Steinberg SM, Edison M, Frame JN, Pass H, Nesbitt JC, Nolden D, Mulshine JL, Glatstein E, Ihde DC.. Patients with Limited Stage Small Cell Lung Cancer Treated with Concurrent Twice Daily Chest Radiotherapy and Etoposide/Cisplatin followed by Cyclophosphamide, Doxorubicin, and Vincristine or In Vitro Selected Chemotherapy. Journal of Clinical Oncology. 1996; 14((3)): 806-13.

Walsh GL, O'Connor M, Willis KM, Milas M, Wong RS, Nesbitt JC, Putnam JB, Lee JJ, Roth JA. Is follow-up of lung cancer patients after resection medically indicated and cost-effective?. Ann. Thorac. Surg. 1995 Dec; 60(6): 1563-70; discussion 1570. PMID: 8787445, PII: 0003-4975(95)00893-4, DOI: 10.1016/0003-4975(95)00893-4, ISSN: 0003-4975.

Kim YH, Dohi DF, Han GR, Zou CP, Oridate N, Walsh GL, Nesbitt JC, Xu XC, Hong WK, Lotan R. Retinoid refractoriness occurs during lung carcinogenesis despite functional retinoid receptors. Cancer Res. 1995 Dec 12/1/1995; 55(23): 5603-10. PMID: 7585641, ISSN: 0008-5472.

Soysal O, Walsh GL, Nesbitt JC, McMurtrey MJ, Roth JA, Putnam JB. Resection of sternal tumors: extent, reconstruction, and survival. Ann. Thorac. Surg. 1995 Nov; 60(5): 1353-8; discussion 1358. PMID: 8526626, PII: 0003-4975(95)00641-W, DOI: 10.1016/0003-4975(95)00641-W, ISSN: 0003-4975.

Shannon VR, Nesbitt JC, Libshitz HI. Malignant pleural mesothelioma after radiation therapy for breast cancer. A report of two additional patients. Cancer. 1995 Aug 8/1/1995; 76(3): 437-41. PMID: 8625125, ISSN: 0008-543X.

Nesbitt JC, Putnam JB, Walsh GL, Roth JA, Mountain CF. Survival in early-stage non-small cell lung cancer. Ann. Thorac. Surg. 1995 Aug; 60(2): 466-72. PMID: 7646126, PII: 000349759500169L, ISSN: 0003-4975.

Walsh GL, Nesbitt JC. Inadequacy, mortality, and thoracoscopy [letter]. Ann. Thorac. Surg. 1995 Jul; 60(1): 233. PMID: 7598614, ISSN: 0003-4975.

Shaw GL, Falk RT, Deslauriers J, Frame JN, Nesbitt JC, Pass HI, Issaq HJ, Hoover RN, Tucker MA. Debrisoquine metabolism and lung cancer risk. Cancer Epidemiol. Biomarkers Prev. 1995 Jan; 4(1): 41-8. PMID: 7894323, ISSN: 1055-9965.

Walsh GL, Nesbitt JC. Tumor implants after thoracoscopic resection of a metastatic sarcoma. Ann. Thorac. Surg. 1995 Jan; 59(1): 215-6. PMID: 7818327, PII: 0003-4975(94)00799-D, DOI: 10.1016/0003-4975(94)00799-D, ISSN: 0003-4975.

Carrasco CH, Nesbitt JC, Charnsangavej C, Ryan B, Walsh GL, Yasumori K, Lawrence DD, Wallace S. Management of tracheal and bronchial stenoses with the Gianturco stent. Ann. Thorac. Surg. 1994 Oct; 58(4): 1012-6; discussion 1017. PMID: 7524459, ISSN: 0003-4975.

Walsh GL, Morice RC, Putnam JB, Nesbitt JC, McMurtrey MJ, Ryan MB, Reising JM, Willis KM, Morton JD, Roth JA. Resection of lung cancer is justified in high-risk patients selected by exercise oxygen consumption. Ann. Thorac. Surg. 1994 Sep; 58(3): 704-10; discussion 711. PMID: 7944692, PII: 0003-4975(94)90731-5, ISSN: 0003-4975.

Shaw GL, Falk RT, Deslauriers J, Nesbitt JC, McKneally MF, Frame JN, Feld R, Issaq HJ, Ruckdeschel JC, Hoover RN. Lung tumor resection does not affect debrisoquine metabolism. Cancer Epidemiol. Biomarkers Prev. 1994 Mar; 3(2): 141-4. PMID: 8049635, ISSN: 1055-9965.

Shaw GL, Gazdar AF, Phelps R, Linnoila RI, Ihde DC, Johnson BE, Oie HK, Pass HI, Steinberg SM, Ghosh BC, Walsh TE, Nesbitt JC, Cotelingam JD, Minna JD, Mulshine JL. Individualized chemotherapy for patients with non-small cell lung cancer determined by prospective identification of neuroendocrine markers and in vitro drug sensitivity testing. Cancer Research. 1993; ((53)): 5181-7.

Johnson BE, Salem C, Nesbitt JC, Gazdar AF, Lesar M, Phelps R, Edison M, Linnoila RI, Phares J, Pass H, Mulsine JL, Minna JD, Glatstein E, Ihde DC.. Limited stage small cell lung cancer treated with concurrent hyperfractionated chest radiotherapy and etoposide/cisplatin. 1993; ((9)): S21-S26.

Nesbitt JC, Miller B, Herrington JL. Multiple Esophageal diverticula: Case Report. Contemporary Surgery. 1988; 13-6.

Nesbitt JC, Sawyers JL. Surgical management of esophageal perforation. Am Surg. 1987 Apr; 53(4): 183-91. PMID: 3579023, ISSN: 0003-1348.

Nesbitt JC, McDougal WS, Lowe W, Abumrad NN, Nylander WA. A new model to study acute and chronic renal failure. Am Surg. 1986 Dec; 52(12): 651-3. PMID: 3789543, ISSN: 0003-1348.

Nesbitt JC, Moise KJ, Sawyers JL. Colorectal carcinoma in pregnancy. Arch Surg. 1985 May; 120(5): 636-40. PMID: 3985804, ISSN: 0004-0010.