Harikrishna Tanjore, Ph.D.

Research Assistant Professor

harikrishna.tanjore@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Biochemistry, University of Hyderabad, Hyderabad, IndiaM.Sc., Medical Biochemistry, Kasturba Medical College, Manipal, IndiaM.Sc., Chemistry, Sri Venkateswara University, Tirupati, India
Office Address
T-1218 MCN, Allergy, Pulmonary and Critical Care Medicine 37232-2650
TN 2650
Publications
Saxon JA, Cheng DS, Han W, Polosukhin VV, McLoed AG, Richmond BW, Gleaves LA, Tanjore H, Sherrill TP, Barham W, Yull FE, Blackwell TS. P52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment. J. Immunol [print-electronic]. 2016 Feb 2/15/2016; 196(4): 1891-9. PMID: 26773153, PMCID: PMC4744539, PII: jimmunol.1501555, DOI: 10.4049/jimmunol.1501555, ISSN: 1550-6606.

Zaynagetdinov R, Sherrill TP, Gleaves LA, Hunt P, Han W, McLoed AG, Saxon JA, Tanjore H, Gulleman PM, Young LR, Blackwell TS. Chronic NF-¿B activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs. Oncotarget. 2016 Feb 2/2/2016; 7(5): 5470-82. PMID: 26756215, PMCID: PMC4868699, PII: 6562, DOI: 10.18632/oncotarget.6562, ISSN: 1949-2553.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PMCID: PMC4838140, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.

Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD. Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Pulm Circ. 2015 Dec; 5(4): 681-90. PMID: 26697175, PMCID: PMC4671742, PII: PC2013257, DOI: 10.1086/683811, ISSN: 2045-8932.

Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am. J. Respir. Cell Mol. Biol. 2015 Jul; 53(1): 50-9. PMID: 25375039, PMCID: PMC4566110, DOI: 10.1165/rcmb.2014-0289OC, ISSN: 1535-4989.

Tanjore H, Lawson WE, Blackwell TS. Endoplasmic reticulum stress as a pro-fibrotic stimulus. Biochim. Biophys. Acta [print-electronic]. 2013 Jul; 1832(7): 940-7. PMID: 23201247, PMCID: PMC3641173, PII: S0925-4439(12)00270-0, DOI: 10.1016/j.bbadis.2012.11.011, ISSN: 0006-3002.

Duncan MB, Yang C, Tanjore H, Boyle PM, Keskin D, Sugimoto H, Zeisberg M, Olsen BR, Kalluri R. Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech [print-electronic]. 2013 Jul; 6(4): 942-51. PMID: 23580202, PMCID: PMC3701214, PII: dmm.011577, DOI: 10.1242/dmm.011577, ISSN: 1754-8411.

Atochina-Vasserman EN, Biktasova A, Abramova E, Cheng DS, Polosukhin VV, Tanjore H, Takahashi S, Sonoda H, Foye L, Venkov C, Ryzhov SV, Novitskiy S, Shlonimskaya N, Ikeda M, Blackwell TS, Lawson WE, Gow AJ, Harris RC, Dikov MM, Tchekneva EE. Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress. Am. J. Physiol. Renal Physiol [print-electronic]. 2013 May 5/15/2013; 304(10): F1295-307. PMID: 23486012, PMCID: PMC3651623, PII: ajprenal.00344.2012, DOI: 10.1152/ajprenal.00344.2012, ISSN: 1522-1466.

Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. ß-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin. Am. J. Respir. Crit. Care Med [print-electronic]. 2013 Mar 3/15/2013; 187(6): 630-9. PMID: 23306543, PMCID: PMC3733436, PII: rccm.201205-0972OC, DOI: 10.1164/rccm.201205-0972OC, ISSN: 1535-4970.

Tanjore H, Blackwell TS, Lawson WE. Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Apr 4/15/2012; 302(8): L721-9. PMID: 22287606, PMCID: PMC3331582, PII: ajplung.00410.2011, DOI: 10.1152/ajplung.00410.2011, ISSN: 1522-1504.

Degryse AL, Xu XC, Newman JL, Mitchell DB, Tanjore H, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Phillips JA, Cogan JD, Blackwell TS, Lawson WE. Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Exp. Lung Res. 2012 Apr; 38(3): 124-34. PMID: 22394286, PMCID: PMC4046256, DOI: 10.3109/01902148.2012.658148, ISSN: 1521-0499.

Tanjore H, Cheng DS, Degryse AL, Zoz DF, Abdolrasulnia R, Lawson WE, Blackwell TS. Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J. Biol. Chem [print-electronic]. 2011 Sep 9/2/2011; 286(35): 30972-80. PMID: 21757695, PMCID: PMC3162456, PII: M110.181164, DOI: 10.1074/jbc.M110.181164, ISSN: 1083-351X.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Jun 6/28/2011; 108(26): 10562-7. PMID: 21670280, PMCID: PMC3127925, PII: 1107559108, DOI: 10.1073/pnas.1107559108, ISSN: 1091-6490.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. TGFß signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Jun; 300(6): L887-97. PMID: 21441353, PMCID: PMC3119129, PII: ajplung.00397.2010, DOI: 10.1152/ajplung.00397.2010, ISSN: 1522-1504.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2010 Oct; 299(4): L442-52. PMID: 20562227, PMCID: PMC2957416, PII: ajplung.00026.2010, DOI: 10.1152/ajplung.00026.2010, ISSN: 1522-1504.

Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J. Biol. Chem [print-electronic]. 2010 Jun 6/25/2010; 285(26): 20202-12. PMID: 20363741, PMCID: PMC2888433, PII: M110.102012, DOI: 10.1074/jbc.M110.102012, ISSN: 1083-351X.

Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am. J. Respir. Crit. Care Med [print-electronic]. 2009 Oct 10/1/2009; 180(7): 657-65. PMID: 19556518, PMCID: PMC2753790, PII: 200903-0322OC, DOI: 10.1164/rccm.200903-0322OC, ISSN: 1535-4970.

Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH, Kalluri R. Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev. Biol [print-electronic]. 2008 Jan 1/15/2008; 313(2): 584-93. PMID: 18082680, PMCID: PMC3947521, PII: S0012-1606(07)01494-7, DOI: 10.1016/j.ydbio.2007.10.047, ISSN: 1095-564X.

Tanjore H, Zeisberg EM, Gerami-Naini B, Kalluri R. Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev. Dyn. 2008 Jan; 237(1): 75-82. PMID: 18058911, DOI: 10.1002/dvdy.21385, ISSN: 1058-8388.

Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J. Biol. Chem [print-electronic]. 2007 Aug 8/10/2007; 282(32): 23337-47. PMID: 17562716, PII: M700194200, DOI: 10.1074/jbc.M700194200, ISSN: 0021-9258.

Hegde ML, Gupta VB, Anitha M, Harikrishna T, Shankar SK, Muthane U, Subba Rao K, Jagannatha Rao KS. Studies on genomic DNA topology and stability in brain regions of Parkinson's disease. Arch. Biochem. Biophys [print-electronic]. 2006 May 5/15/2006; 449(1-2): 143-56. PMID: 16600170, PII: S0003-9861(06)00071-3, DOI: 10.1016/j.abb.2006.02.018, ISSN: 0003-9861.

Tanjore H, Kalluri R. The role of type IV collagen and basement membranes in cancer progression and metastasis. Am. J. Pathol. 2006 Mar; 168(3): 715-7. PMID: 16507886, PMCID: PMC1606530, PII: S0002-9440(10)62131-1, DOI: 10.2353/ajpath.2006.051321, ISSN: 0002-9440.

Krishna TH, Mahipal S, Sudhakar A, Sugimoto H, Kalluri R, Rao KS. Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase. J. Neurochem. 2005 Feb; 92(4): 818-23. PMID: 15686483, PII: JNC2923, DOI: 10.1111/j.1471-4159.2004.02923.x, ISSN: 0022-3042.

Krishna TH, Hemkal A, Rao KS. The presence of 3'-5' exonuclease activity in rat brain neurons and its role in template-driven extension of 3'-mismatched primers by DNA-polymerase beta in aging neurons. Neurochem. Res. 2004 Apr; 29(4): 761-70. PMID: 15098939, ISSN: 0364-3190.

Raji NS, Krishna TH, Rao KS. DNA-polymerase alpha, beta, delta and epsilon activities in isolated neuronal and astroglial cell fractions from developing and aging rat cerebral cortex. Int. J. Dev. Neurosci. 2002 Oct; 20(6): 491-6. PMID: 12392752, PII: S0736574802000795, ISSN: 0736-5748.

Rao KS, Annapurna VV, Raji NS, Harikrishna T. Loss of base excision repair in aging rat neurons and its restoration by DNA polymerase beta. Brain Res. Mol. Brain Res. 2000 Dec 12/28/2000; 85(1-2): 251-9. PMID: 11146128, PII: S0169328X00002667, ISSN: 0169-328X.