Sukhbir S. Mokha, Ph.D.

Professor

sukhbir.mokha@vanderbilt.edu
Faculty Appointments
Professor of Neuroscience & Pharmacology at Meharry Medical College Adjunct Professor of Pharmacology
Education
Ph.D., Physiology, University of Edinburgh, Edinburgh, United KingdomM.Sc., Pharmacology, University of Southampton, Southampton, United KingdomB.Sc., Anatomy, Punjab State Medical College, Punjab, India
Office Address
Dept of Neuroscience and Pharmacology, Meharry Medical College
1005 Dr. D.B. Todd Jr. Blvd.
Nashville, TN 37208
Research Keywords
Neurobiology of pain and analgesia at systems, cellular, molecular and genomic levels. Sex-related differences in the perception and control of pain mechanisms: electropharmacological, behavioral, cellular, molecular and genomic analysis.
Publications
Nag S, Mokha SS. Testosterone is essential for alpha(2)-adrenoceptor-induced antinociception in the trigeminal region of the male rat. Neurosci. Lett [print-electronic]. 2009 Dec 12/18/2009; 467(1): 48-52. PMID: 19819297, PMCID: PMC2783499, PII: S0304-3940(09)01326-3, DOI: 10.1016/j.neulet.2009.10.016, ISSN: 1872-7972.

Claiborne JA, Nag S, Mokha SS. Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat. Neurosci. Lett [print-electronic]. 2009 Jun 6/5/2009; 456(2): 59-63. PMID: 19429134, PMCID: PMC2692664, PII: S0304-3940(09)00427-3, DOI: 10.1016/j.neulet.2009.03.106, ISSN: 1872-7972.

Nag S, Wang Q, Limbird LE, Mokha SS. Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behav. Brain Res [print-electronic]. 2009 Feb 2/11/2009; 197(2): 457-61. PMID: 18957308, PMCID: PMC2645350, PII: S0166-4328(08)00546-9, DOI: 10.1016/j.bbr.2008.09.036, ISSN: 1872-7549.

Lee MK, Choi BY, Yang GY, Jeon HJ, Kyung HM, Kwon OW, Park HS, Bae YC, Mokha SS, Ahn DK. Low doses of cannabinoids enhance the antinociceptive effects of intracisternally administered mGluRs groups II and III agonists in formalin-induced TMJ nociception in rats. Pain [print-electronic]. 2008 Oct 10/15/2008; 139(2): 367-75. PMID: 18565658, PMCID: PMC2590926, PII: S0304-3959(08)00241-8, DOI: 10.1016/j.pain.2008.05.005, ISSN: 1872-6623.

Thompson AD, Angelotti T, Nag S, Mokha SS. Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone. Neuroscience [print-electronic]. 2008 Jun 6/2/2008; 153(4): 1268-77. PMID: 18434028, PMCID: PMC2577833, PII: S0306-4522(08)00371-0, DOI: 10.1016/j.neuroscience.2008.03.008, ISSN: 0306-4522.

Ahn DK, Choi HS, Yeo SP, Woo YW, Lee MK, Yang GY, Jeon HJ, Park JS, Mokha SS. Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception. Pain [print-electronic]. 2007 Nov; 132(1-2): 23-32. PMID: 17321048, PII: S0304-3959(07)00023-1, DOI: 10.1016/j.pain.2007.01.015, ISSN: 1872-6623.

Claiborne J, Nag S, Mokha SS. Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male. J. Neurosci. 2006 Dec 12/13/2006; 26(50): 13048-53. PMID: 17167094, PII: 26/50/13048, DOI: 10.1523/JNEUROSCI.4783-06.2006, ISSN: 1529-2401.

Nag S, Mokha SS. Activation of alpha2-adrenoceptors in the trigeminal region produces sex-specific modulation of nociception in the rat. Neuroscience [print-electronic]. 2006 Nov 11/3/2006; 142(4): 1255-62. PMID: 16934408, PII: S0306-4522(06)00989-4, DOI: 10.1016/j.neuroscience.2006.07.012, ISSN: 0306-4522.

Nag S, Mokha SS. Estrogen attenuates antinociception produced by stimulation of K├Âlliker-Fuse nucleus in the rat. Eur. J. Neurosci. 2004 Dec; 20(11): 3203-7. PMID: 15579177, PII: EJN3775, DOI: 10.1111/j.1460-9568.2004.03775.x, ISSN: 0953-816X.

Flores CA, Shughrue P, Petersen SL, Mokha SS. Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat. Neuroscience. 2003; 118(3): 769-78. PMID: 12710984, PII: S030645220201000X, ISSN: 0306-4522.

Wang X, Zhang Z, Bains R, Mokha SS. Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat. Pain. 2002; 98(1-2): 27-35.

Flores CA, Wang XM, Zhang KM, Mokha SS. Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations. Neuroscience. 2001; 105(2): 489-98.

Wang XM, Zhang KM, Long LO, Flores CA, Mokha SS. Endomorphin-1 and endomorphin-2 modulate responses of trigeminal neurons evoked by N-methyl-D-aspartic acid and somatosensory stimuli. J Neurophysiol. 2000; 83(6): 3570-4.

Wang XM, Zhang KM, Long LO, Mokha SS. Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses. Neuroscience. 1999; 93(2): 703-12.

Zhang KM, Wang XM, Peterson AM, Chen WY, Mokha SS. Alpha2-adrenoceptors modulate NMDA-evoked responses of neurons in superficial and deeper dorsal horn of the medulla. J Neurophysiol. 1998; 80(4): 2210-4.

Wang XM, Yan JQ, Zhang KM, Mokha SS. Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Brain Res. 1996; 739(1-2): 235-43.

Wang XM, Zhang KM, Mokha SS. Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. J Neurophysiol. 1996; 76(5): 3568-72.

Wang XM, Mokha SS. Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of trigeminothalamic neurons. J Neurophysiol. 1996; 76(3): 2093-6.

Zhang KM, Wang XM, Mokha SS. Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis). Brain Res. 1996; 719(1-2): 229-33.

Mokha SS. Morphine differentially modulates nociceptive input in the superficial versus the deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Brain Res. 1993; 626(1-2): 318-21.

Mokha SS. Morphine alters the firing of cold-receptive neurons in the superficial dorsal horn of the medulla in the rat. Brain Res. 1993; 602(2): 205-14.

Mokha SS. Differential influence of naloxone on the responses of nociceptive neurons in the superficial versus the deeper dorsal horn of the medulla in the rat. Pain. 1992; 49(3): 405-13.

Mokha SS, Iggo A. Mechanisms mediating the brain stem control of somatosensory transmission in the dorsal horn of the cat's spinal cord: an intracellular analysis. Exp Brain Res. 1987; 69(1): 93-106. PMID: 2830129, ISSN: 0014-4819.

Mokha SS, Goldsmith GE, Hellon RF, Puri R. Hypothalamic control of nocireceptive and other neurons in the marginal layer of the dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Exp Brain Res. 1987; 65: 427-36.

Mokha SS, McMillan JA, Iggo A. Pathways mediating descending control of spinal nociceptive transmission from the nuclei locus coeruleus (LC) and raphe magnus (NRM) in the cat. Exp Brain Res. 1986; 61(3): 597-606. PMID: 3007190, ISSN: 0014-4819.

Mokha SS, McMillan JA, Iggo A. Descending control of spinal nociceptive transmission. Actions produced on spinal multireceptive neurones from the nuclei locus coeruleus (LC) and raphe magnus (NRM). Exp Brain Res. 1985; 58(2): 213-26. PMID: 2987012, ISSN: 0014-4819.

Mokha SS, McMillan JA, Iggo A. Dorsal root potentials in the cat: effects of bicuculline. Brain Res. 1983 Jan 1/24/1983; 259(2): 313-8. PMID: 6297676, PII: 0006-8993(83)91265-9, ISSN: 0006-8993.

Mokha,S.S., McMillan, J.A. and Iggo, A. Descending influences on spinal nociceptive neurones from locus coeruleus: actions ,pathways, neurotransmitters and mechanisms. Advances in Pain Research and Therapy, Vol. 5, eds., Bonica et al., Raven Press , New York. 1983; 5: 387-92.

Iggo, A. and Mokha,S.S. Neurophysiology of opioid peptides. Neuropeptides -basic and clinical aspects' (proceedings of the 11th Pfizer International Symposium), eds., Fink, G. and Walley, L.J., Churchill Livingstone, Edinburgh. 1982; 24-32.

Sinclair JG, Fox RE, Mokha SS, Iggo A. The effect of naloxone on the inhibition of nociceptor driven neurones in the cat spinal cord. Q J Exp Physiol Cogn Med Sci. 1980 Jul; 65(3): 181-8. PMID: 6251507, ISSN: 0033-5541.

Fox RE, Holloway JA, Iggo A, Mokha SS. Spinothalamic neurones in the cat: some electrophysiological observations. Brain Res. 1980 Jan 1/20/1980; 182(1): 186-90. PMID: 7350987, PII: 0006-8993(80)90843-4, ISSN: 0006-8993.

Fox RE, Holloway JA, Iggo A, Mokha SS. Some physiological properties of spinothalamic tract neurones in the cat [proceedings]. J. Physiol. (Lond.). 1978 Dec; 285: 58P. PMID: 745125, ISSN: 0022-3751.