Mark P. de Caestecker, M.B.B.S., Ph.D.


Visit Lab Site

Faculty Appointments
Professor of Medicine Professor of Cell & Developmental BiologyProfessor of Surgery
Ph.D., Medicine, University of Manchester, Manchester, United KingdomM.B.B.S., Internal Medicine, London University, London, United KingdomM.A., Medicine, University of Cambridge, Cambridge, United KingdomB.A., Medical Sciences, University of Cambridge, Cambridge, United Kingdom
Office Address
S3223 MCN
TN 2372
Research Description
Our laboratory is interested in the mechanisms and therapeutic manipulation of pathways and cellular responses involved in promoting healthy cellular repair after organ injury, with a particular focus on the transition of acute kidney injury to fibrosis and chronic kidney disease. Our current focus includes:

a) Phenotypic screening for small molecules that promote proliferative repair of damaged epithelium after injury. These studies are based on a long-term collaboration with Dr. Neil Hukriede from the University of Pittsburgh, who has developed a phenotypic screen in zebrafish to identify compounds that promote proliferative expansion of nephron progenitor cells. Using this approach we have identified a new family of highly selective HDAC inhibitors that promote non-scarring repair after acute kidney injury, that are effective in multiple toxic and surgical models of kidney injury, and importantly, are effective when given days after the initiating injury. We are currently working on target identification and SAR for optimization.

b) Studying the regulation, role and therapeutic manipulation of retinoic acid signaling in promoting effective repair after acute kidney injury. We are studying the cellular origins and effectors of retinoic acid signaling activity after acute kidney injury; exploring the role of immune effectors in mediating these effects; and develop new, non-toxic therapeutic approaches to enhance this natural response and promote effective repair after kidney injury.

Our laboratory also studies the role of BMP signaling in pulmonary hypertension. Human genetic studies indicate that this signaling pathway plays an important role in modifying pulmonary vascular responses in disease. We have shown that Bmp signaling exerts distinct opposing, cell specific effects on pulmonary vascular remodeling and tone. We are currently using genetic models in mice as well as patient derived cells to evaluate effect of inherited mutations in the BMP type 2-receptor, BMPR2, on pulmonary vascular cell function. Our specific focus is on how these mutations affect endothelial cell function, specifically metabolic function and perivascular inflammation, and how these pathologic responses promote pulmonary hypertension in genetically modified mice.

Clinical Description
Mark de Caestecker. M.B., B.S., Ph.D. is a physician scientist and Associate Professor in the Division of Nephrology at Vanderbilt University Medical Center. He attends the general medical service and provides consultation services in nephrology at the Nashville A Hospital 8 weeks a year. Dr de Caestecker is also the Bench research Immersion Director for medical Students interested in bench research, and is director of the Vanderbilt Program in Molecular Medicine, a clinical enrichment program for biomedical sciences PhD students and post doctoral fellows
Research Keywords
Kidney regeneration and therapy, kidney development, retinoic acid signaling, immune cells, macrophages, pulmonary vasculature, genetics, BMP signaling, endothelial cells
Clinical Research Keywords
Nephrology, General Internal Medicine, VA Hospital Nashville
Hukriede N, Vogt A, de Caestecker M. Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury. Nephron [print-electronic]. 2017 Jun 6/15/2017; PMID: 28614822, PII: 000476079, DOI: 10.1159/000476079, ISSN: 2235-3186.

Frump AL, Datta A, Ghose S, West J, de Caestecker MP. Genotype-phenotype effects of Bmpr2 mutations on disease severity in mouse models of pulmonary hypertension. Pulm Circ. 2016 Dec; 6(4): 597-607. PMID: 28090303, PMCID: PMC5210048, PII: PC2013387, DOI: 10.1086/688930, ISSN: 2045-8932.

Skrypnyk NI, Voziyan P, Yang H, de Caestecker CR, Theberge MC, Drouin M, Hudson B, Harris RC, de Caestecker MP. Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2016 Aug 8/1/2016; 311(2): F268-77. PMID: 27194713, PMCID: PMC5008672, PII: ajprenal.00056.2016, DOI: 10.1152/ajprenal.00056.2016, ISSN: 1522-1466.

West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. Pulm Circ. 2016 Jun; 6(2): 211-23. PMID: 27252848, PMCID: PMC4869926, PII: PC2013314, DOI: 10.1086/686140, ISSN: 2045-8932.

Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP. Bridging translation for acute kidney injury with better preclinical modeling of human disease. Am. J. Physiol. Renal Physiol [print-electronic]. 2016 May 5/15/2016; 310(10): F972-84. PMID: 26962107, PMCID: PMC4889323, PII: ajprenal.00552.2015, DOI: 10.1152/ajprenal.00552.2015, ISSN: 1522-1466.

Chiba T, Skrypnyk NI, Skvarca LB, Penchev R, Zhang KX, Rochon ER, Fall JL, Paueksakon P, Yang H, Alford CE, Roman BL, Zhang MZ, Harris R, Hukriede NA, de Caestecker MP. Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI. J. Am. Soc. Nephrol [print-electronic]. 2016 Feb; 27(2): 495-508. PMID: 26109319, PMCID: PMC4731115, PII: ASN.2014111108, DOI: 10.1681/ASN.2014111108, ISSN: 1533-3450.

King T, de Caestecker M, Lowery JW. Reply to "Bone morphogenetic protein's contribution to pulmonary artery hypertension". Surg Neurol Int. 2016; 7: 91. PMID: 27857855, PMCID: PMC5093875, PII: SNI-7-91, DOI: 10.4103/2152-7806.192635, ISSN: 2229-5097.

Skrypnyk NI, Sanker S, Brilli-Skvarca L, Novitskaya T, Woods C, Chiba T, Patel K, Goldberg ND, McDermott L, Vinson PN, Calcutt MW, Huryn DM, Vernetti LA, Vogt A, Hukriede N, de Caestecker MP. Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2015 Dec 12/9/2015; ajprenal.00503.2015. PMID: 26661656, PMCID: PMC4835925, PII: ajprenal.00503.2015, DOI: 10.1152/ajprenal.00503.2015, ISSN: 1522-1466.

de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE, Pullen N, Okusa MD, Faubel S, . Bridging Translation by Improving Preclinical Study Design in AKI. J. Am. Soc. Nephrol [print-electronic]. 2015 Dec; 26(12): 2905-16. PMID: 26538634, PMCID: PMC4657852, PII: ASN.2015070832, DOI: 10.1681/ASN.2015070832, ISSN: 1533-3450.

Cirio MC, de Caestecker MP, Hukriede NA. Zebrafish Models of Kidney Damage and Repair. Curr Pathobiol Rep [print-electronic]. 2015 Jun; 3(2): 163-70. PMID: 28690924, PMCID: PMC5497754, DOI: 10.1007/s40139-015-0080-4, ISSN: 2167-485X.

Chiba T, Hukriede N, de Caestecker MP. Kidney Regeneration: Lessons from Development. Curr Pathobiol Rep. 2015 Mar; 3(1): 67-79. PMID: 26120499, PMCID: PMC4477536, DOI: 10.1007/s40139-015-0069-z.

Prewitt AR, Ghose S, Frump AL, Datta A, Austin ED, Kenworthy AK, de Caestecker MP. Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. J. Biol. Chem [print-electronic]. 2015 Jan 1/9/2015; 290(2): 960-71. PMID: 25411245, PMCID: PMC4294523, PII: M114.591057, DOI: 10.1074/jbc.M114.591057, ISSN: 1083-351X.

Pierce J, Murphy AJ, Panzer A, de Caestecker C, Ayers GD, Neblett D, Saito-Diaz K, de Caestecker M, Lovvorn HN. SIX2 Effects on Wilms Tumor Biology. Transl Oncol. 2014 Dec; 7(6): 800-11. PMID: 25500091, PMCID: PMC4311027, PII: S1936-5233(14)00098-9, DOI: 10.1016/j.tranon.2014.09.005.

Cirio MC, de Groh ED, de Caestecker MP, Davidson AJ, Hukriede NA. Kidney regeneration: common themes from the embryo to the adult. Pediatr. Nephrol [print-electronic]. 2014 Apr; 29(4): 553-64. PMID: 24005792, PMCID: PMC3944192, DOI: 10.1007/s00467-013-2597-2, ISSN: 1432-198X.

Novitskaya T, McDermott L, Zhang KX, Chiba T, Paueksakon P, Hukriede NA, de Caestecker MP. A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2014 Mar 3/1/2014; 306(5): F496-504. PMID: 24370591, PMCID: PMC3949031, PII: ajprenal.00534.2013, DOI: 10.1152/ajprenal.00534.2013, ISSN: 1522-1466.

Murphy AJ, Pierce J, de Caestecker C, Libes J, Neblett D, de Caestecker M, Perantoni AO, Tanigawa S, Anderson JR, Dome JS, Das A, Carroll TJ, Lovvorn HN. Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor. Pediatr Blood Cancer [print-electronic]. 2014 Feb; 61(2): 198-205. PMID: 24115727, PMCID: PMC3955491, DOI: 10.1002/pbc.24788, ISSN: 1545-5017.

Murphy AJ, Pierce J, de Caestecker C, Ayers GD, Zhao A, Krebs JR, Saito-Diaz VK, Lee E, Perantoni AO, de Caestecker MP, Lovvorn HN. CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus. Oncotarget. 2014 Jan 1/30/2014; 5(2): 386-402. PMID: 24481423, PMCID: PMC3964215, PII: 1566, DOI: 10.18632/oncotarget.1566, ISSN: 1949-2553.

Brilli LL, Swanhart LM, de Caestecker MP, Hukriede NA. HDAC inhibitors in kidney development and disease. Pediatr. Nephrol [print-electronic]. 2013 Oct; 28(10): 1909-21. PMID: 23052657, PMCID: PMC3751322, DOI: 10.1007/s00467-012-2320-8, ISSN: 1432-198X.

Skrypnyk NI, Harris RC, de Caestecker MP. Ischemia-reperfusion model of acute kidney injury and post injury fibrosis in mice. J Vis Exp. 2013 Aug 8/9/2013; (78): PMID: 23963468, PMCID: PMC3854859, DOI: 10.3791/50495, ISSN: 1940-087X.

Cianciolo Cosentino C, Skrypnyk NI, Brilli LL, Chiba T, Novitskaya T, Woods C, West J, Korotchenko VN, McDermott L, Day BW, Davidson AJ, Harris RC, de Caestecker MP, Hukriede NA. Histone deacetylase inhibitor enhances recovery after AKI. J. Am. Soc. Nephrol [print-electronic]. 2013 May; 24(6): 943-53. PMID: 23620402, PMCID: PMC3665399, PII: ASN.2012111055, DOI: 10.1681/ASN.2012111055, ISSN: 1533-3450.

Frump AL, Lowery JW, Hamid R, Austin ED, de Caestecker M. Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension. PLoS ONE. 2013; 8(11): e80319. PMID: 24224048, PMCID: PMC3818254, PII: PONE-D-13-31667, DOI: 10.1371/journal.pone.0080319, ISSN: 1932-6203.

Walker KA, Sims-Lucas S, Di Giovanni VE, Schaefer C, Sunseri WM, Novitskaya T, de Caestecker MP, Chen F, Bates CM. Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux. PLoS ONE [print-electronic]. 2013; 8(2): e56062. PMID: 23409123, PMCID: PMC3567073, PII: PONE-D-12-35459, DOI: 10.1371/journal.pone.0056062, ISSN: 1932-6203.

Murphy AJ, de Caestecker C, Pierce J, Boyle SC, Ayers GD, Zhao Z, Libes JM, Correa H, Walter T, Huppert SS, Perantoni AO, de Caestecker MP, Lovvorn HN. CITED1 expression in liver development and hepatoblastoma. Neoplasia. 2012 Dec; 14(12): 1153-63. PMID: 23308048, PMCID: PMC3540941, ISSN: 1476-5586.

Murphy AJ, Axt JR, de Caestecker C, Pierce J, Correa H, Seeley EH, Caprioli RM, Newton MW, de Caestecker MP, Lovvorn HN. Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa. Int. J. Cancer [print-electronic]. 2012 Sep 9/15/2012; 131(6): E983-94. PMID: 22437966, PMCID: PMC3402639, DOI: 10.1002/ijc.27544, ISSN: 1097-0215.

Murphy AJ, Pierce J, de Caestecker C, Taylor C, Anderson JR, Perantoni AO, de Caestecker MP, Lovvorn HN. SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor. J. Pediatr. Surg. 2012 Jun; 47(6): 1239-49. PMID: 22703800, PMCID: PMC3377935, PII: S0022-3468(12)00274-6, DOI: 10.1016/j.jpedsurg.2012.03.034, ISSN: 1531-5037.

Oxburgh L, de Caestecker MP. Ischemia-reperfusion injury of the mouse kidney. Methods Mol. Biol. 2012; 886: 363-79. PMID: 22639277, DOI: 10.1007/978-1-61779-851-1_32, ISSN: 1940-6029.

Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R. ß-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors. Am. J. Pathol [print-electronic]. 2011 Dec; 179(6): 3045-55. PMID: 21983638, PMCID: PMC3260797, PII: S0002-9440(11)00808-X, DOI: 10.1016/j.ajpath.2011.08.006, ISSN: 1525-2191.

Brown AC, Adams D, de Caestecker M, Yang X, Friesel R, Oxburgh L. FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development. Development [print-electronic]. 2011 Dec; 138(23): 5099-112. PMID: 22031548, PMCID: PMC3210493, PII: dev.065995, DOI: 10.1242/dev.065995, ISSN: 1477-9129.

Novitskaya T, Baserga M, de Caestecker MP. Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice. Endocrinology [print-electronic]. 2011 Jun; 152(6): 2503-16. PMID: 21486933, PMCID: PMC3100618, PII: en.2010-1385, DOI: 10.1210/en.2010-1385, ISSN: 1945-7170.

Swanhart LM, Cosentino CC, Diep CQ, Davidson AJ, de Caestecker M, Hukriede NA. Zebrafish kidney development: basic science to translational research. Birth Defects Res. C Embryo Today. 2011 Jun; 93(2): 141-56. PMID: 21671354, PMCID: PMC3694221, DOI: 10.1002/bdrc.20209, ISSN: 1542-9768.

Lowery JW, Frump AL, Anderson L, DiCarlo GE, Jones MT, de Caestecker MP. ID family protein expression and regulation in hypoxic pulmonary hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2010 Dec; 299(6): R1463-77. PMID: 20881097, PMCID: PMC3007180, PII: ajpregu.00866.2009, DOI: 10.1152/ajpregu.00866.2009, ISSN: 1522-1490.

Lowery JW, de Caestecker MP. BMP signaling in vascular development and disease. Cytokine Growth Factor Rev [print-electronic]. 2010 Aug; 21(4): 287-98. PMID: 20674464, PMCID: PMC2939258, PII: S1359-6101(10)00047-X, DOI: 10.1016/j.cytogfr.2010.06.001, ISSN: 1879-0305.

Zhang MZ, Su Y, Yao B, Zheng W, Decaestecker M, Harris RC. Assessing the application of tissue microarray technology to kidney research. J. Histochem. Cytochem [print-electronic]. 2010 May; 58(5): 413-20. PMID: 20086233, PMCID: PMC2857813, PII: jhc.2009.954966, DOI: 10.1369/jhc.2009.954966, ISSN: 1551-5044.

Anderson L, Lowery JW, Frank DB, Novitskaya T, Jones M, Mortlock DP, Chandler RL, de Caestecker MP. Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2010 Mar; 298(3): R833-42. PMID: 20042692, PMCID: PMC2838658, PII: 00534.2009, DOI: 10.1152/ajpregu.00534.2009, ISSN: 1522-1490.

Sparrow DB, Boyle SC, Sams RS, Mazuruk B, Zhang L, Moeckel GW, Dunwoodie SL, de Caestecker MP. Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia. J. Am. Soc. Nephrol [print-electronic]. 2009 Apr; 20(4): 777-86. PMID: 19297558, PMCID: PMC2663829, PII: ASN.2008050547, DOI: 10.1681/ASN.2008050547, ISSN: 1533-3450.

Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS. NFATc1 identifies a population of proximal tubule cell progenitors. J. Am. Soc. Nephrol [print-electronic]. 2009 Feb; 20(2): 311-21. PMID: 19118153, PMCID: PMC2637056, PII: ASN.2008010094, DOI: 10.1681/ASN.2008010094, ISSN: 1533-3450.

Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M. Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jan; 294(1): L98-109. PMID: 18024717, PII: 00034.2007, DOI: 10.1152/ajplung.00034.2007, ISSN: 1040-0605.

Boyle S, Misfeldt A, Chandler KJ, Deal KK, Southard-Smith EM, Mortlock DP, Baldwin HS, de Caestecker M. Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev. Biol [print-electronic]. 2008 Jan 1/1/2008; 313(1): 234-45. PMID: 18061157, PMCID: PMC2699557, PII: S0012-1606(07)01457-1, DOI: 10.1016/j.ydbio.2007.10.014, ISSN: 1095-564X.

Boyle S, Shioda T, Perantoni AO, de Caestecker M. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev. Dyn. 2007 Aug; 236(8): 2321-30. PMID: 17615577, DOI: 10.1002/dvdy.21242, ISSN: 1058-8388.

de Caestecker MP. Angiopoietin-2 and glomerular proteinuria [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2007 Aug; 18(8): 2217-8. PMID: 17625115, PII: ASN.2007060650, DOI: 10.1681/ASN.2007060650, ISSN: 1046-6673.

Lovvorn HN, Westrup J, Opperman S, Boyle S, Shi G, Anderson J, Perlman EJ, Perantoni AO, Wills M, de Caestecker M. CITED1 expression in Wilms' tumor and embryonic kidney. Neoplasia. 2007 Jul; 9(7): 589-600. PMID: 17710162, PMCID: PMC1941694, ISSN: 1476-5586.

Lovvorn HN, Boyle S, Shi G, Shyr Y, Wills ML, Perantoni AO, de Caestecker M. Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1. J. Pediatr. Surg. 2007 Mar; 42(3): 474-81. PMID: 17336183, PMCID: PMC3028602, PII: S0022-3468(06)00796-2, DOI: 10.1016/j.jpedsurg.2006.10.054, ISSN: 1531-5037.

Shi G, Boyle SC, Sparrow DB, Dunwoodie SL, Shioda T, de Caestecker MP. The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner. J. Biol. Chem [print-electronic]. 2006 Sep 9/15/2006; 281(37): 27426-35. PMID: 16864582, PII: M602631200, DOI: 10.1074/jbc.M602631200, ISSN: 0021-9258.

Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J. Am. Soc. Nephrol [print-electronic]. 2006 Sep; 17(9): 2504-12. PMID: 16899516, PII: ASN.2006030278, DOI: 10.1681/ASN.2006030278, ISSN: 1046-6673.

Boyle S, de Caestecker M. Role of transcriptional networks in coordinating early events during kidney development. Am. J. Physiol. Renal Physiol. 2006 Jul; 291(1): F1-8. PMID: 16760375, PII: 291/1/F1, DOI: 10.1152/ajprenal.00447.2005, ISSN: 1931-857X.

de Caestecker M. Serotonin signaling in pulmonary hypertension [editorial]. Circ. Res. 2006 May 5/26/2006; 98(10): 1229-31. PMID: 16728665, PII: 98/10/1229, DOI: 10.1161/01.RES.0000225927.04710.33, ISSN: 1524-4571.

Chen J, Boyle S, Zhao M, Su W, Takahashi K, Davis L, Decaestecker M, Takahashi T, Breyer MD, Hao CM. Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J. Am. Soc. Nephrol [print-electronic]. 2006 May; 17(5): 1283-91. PMID: 16571784, PII: ASN.2005101032, DOI: 10.1681/ASN.2005101032, ISSN: 1046-6673.

Frank D, Johnson J, de Caestecker M. Bone morphogenetic protein 4 promotes vascular remodeling in hypoxic pulmonary hypertension. Chest. 2005 Dec; 128(6 Suppl): 590S-591S. PMID: 16373851, PII: 128/6_suppl/590S, DOI: 10.1378/chest.128.6_suppl.590S, ISSN: 0012-3692.

Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ. Res [print-electronic]. 2005 Sep 9/2/2005; 97(5): 496-504. PMID: 16100039, PII: 01.RES.0000181152.65534.07, DOI: 10.1161/01.RES.0000181152.65534.07, ISSN: 1524-4571.

Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP. Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J. Am. Soc. Nephrol [print-electronic]. 2005 Jun; 16(6): 1632-44. PMID: 15843474, PII: ASN.2004060476, DOI: 10.1681/ASN.2004060476, ISSN: 1046-6673.

Chacko BM, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, De Caestecker M, Lin K. Structural basis of heteromeric smad protein assembly in TGF-beta signaling. Mol. Cell. 2004 Sep 9/10/2004; 15(5): 813-23. PMID: 15350224, PII: S1097276504004381, DOI: 10.1016/j.molcel.2004.07.016, ISSN: 1097-2765.

de Caestecker M. The transforming growth factor-beta superfamily of receptors. Cytokine Growth Factor Rev. 2004 Feb; 15(1): 1-11. PMID: 14746809, PII: S135961010300100X, ISSN: 1359-6101.

Hayashida T, Decaestecker M, Schnaper HW. Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB J [print-electronic]. 2003 Aug; 17(11): 1576-8. PMID: 12824291, PII: 03-0037fje, DOI: 10.1096/fj.03-0037fje, ISSN: 1530-6860.

de Caestecker MP, Bottomley M, Bhattacharyya S, Payne TL, Roberts AB, Yelick PC. The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem. Biophys. Res. Commun. 2002 May 5/24/2002; 293(5): 1556-65. PMID: 12054694, PII: S0006-291X(02)00424-2, DOI: 10.1016/S0006-291X(02)00424-2, ISSN: 0006-291X.

Qin BY, Chacko BM, Lam SS, de Caestecker MP, Correia JJ, Lin K. Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell. 2001 Dec; 8(6): 1303-12. PMID: 11779505, PII: S1097-2765(01)00417-8, ISSN: 1097-2765.

Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J. Biol. Chem [print-electronic]. 2001 Jun 6/1/2001; 276(22): 19332-9. PMID: 11279102, PII: M100606200, DOI: 10.1074/jbc.M100606200, ISSN: 0021-9258.

Watanabe H, de Caestecker MP, Yamada Y. Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. J. Biol. Chem [print-electronic]. 2001 Apr 4/27/2001; 276(17): 14466-73. PMID: 11278290, PII: M005724200, DOI: 10.1074/jbc.M005724200, ISSN: 0021-9258.

Chacko BM, Qin B, Correia JJ, Lam SS, de Caestecker MP, Lin K. The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization. Nat. Struct. Biol. 2001 Mar; 8(3): 248-53. PMID: 11224571, PII: 84995, DOI: 10.1038/84995, ISSN: 1072-8368.

Lee DK, Park SH, Yi Y, Choi SG, Lee C, Parks WT, Cho H, de Caestecker MP, Shaul Y, Roberts AB, Kim SJ. The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. Genes Dev. 2001 Feb 2/15/2001; 15(4): 455-66. PMID: 11230153, PMCID: PMC312630, DOI: 10.1101/gad.856201, ISSN: 0890-9369.

De Caestecker M, Meyrick B. Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension. Respir. Res [print-electronic]. 2001; 2(4): 193-7. PMID: 11686884, PMCID: PMC59576, ISSN: 1465-9921.

Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat. Cell Biol. 2000 Dec; 2(12): 915-21. PMID: 11146656, DOI: 10.1038/35046566, ISSN: 1465-7392.

Tsang M, Kim R, de Caestecker MP, Kudoh T, Roberts AB, Dawid IB. Zebrafish nma is involved in TGFbeta family signaling. Genesis. 2000 Oct; 28(2): 47-57. PMID: 11064421, PII: 10.1002/1526-968X(200010)28:2<47::AID-GENE20>3.0.CO;2-S, ISSN: 1526-954X.

de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-beta signaling in cancer. J. Natl. Cancer Inst. 2000 Sep 9/6/2000; 92(17): 1388-402. PMID: 10974075, ISSN: 0027-8874.

Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Genes Dev. 2000 Jul 7/1/2000; 14(13): 1605-16. PMID: 10887155, PMCID: PMC316742, ISSN: 0890-9369.

Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J. Biol. Chem. 2000 Mar 3/24/2000; 275(12): 8825-34. PMID: 10722728, ISSN: 0021-9258.

de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJ. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J. Biol. Chem. 2000 Jan 1/21/2000; 275(3): 2115-22. PMID: 10636916, ISSN: 0021-9258.

Poncelet AC, de Caestecker MP, Schnaper HW. The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int. 1999 Oct; 56(4): 1354-65. PMID: 10504488, PII: kid680, DOI: 10.1046/j.1523-1755.1999.00680.x, ISSN: 0085-2538.

Vindevoghel L, Lechleider RJ, Kon A, de Caestecker MP, Uitto J, Roberts AB, Mauviel A. SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta. Proc. Natl. Acad. Sci. U.S.A. 1998 Dec 12/8/1998; 95(25): 14769-74. PMID: 9843964, PMCID: PMC24524, ISSN: 0027-8424.

Shioda T, Lechleider RJ, Dunwoodie SL, Li H, Yahata T, de Caestecker MP, Fenner MH, Roberts AB, Isselbacher KJ. Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc. Natl. Acad. Sci. U.S.A. 1998 Aug 8/18/1998; 95(17): 9785-90. PMID: 9707553, PMCID: PMC21414, ISSN: 0027-8424.

de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, Lechleider RJ. Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev. 1998 Jun 6/1/1998; 12(11): 1587-92. PMID: 9620846, PMCID: PMC316877, ISSN: 0890-9369.

de Caestecker MP, Hemmati P, Larisch-Bloch S, Ajmera R, Roberts AB, Lechleider RJ. Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 1997 May 5/23/1997; 272(21): 13690-6. PMID: 9153220, ISSN: 0021-9258.

Lechleider RJ, de Caestecker MP, Dehejia A, Polymeropoulos MH, Roberts AB. Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1. J. Biol. Chem. 1996 Jul 7/26/1996; 271(30): 17617-20. PMID: 8663601, ISSN: 0021-9258.

Mallick NP, de Caestecker MP. The changing population on renal replacement therapy: its clinical and economic impact in Europe. Nephrol. Dial. Transplant. 1996; 11 Suppl 2: 2-5. PMID: 8803985, ISSN: 0931-0509.

de Caestecker MP, Bottomley M, Telfer BA, Hutchinson IV, Vose BM, Ballardie FW. Detection of abnormal peripheral blood mononuclear cell cytokine networks in human IgA nephropathy. Kidney Int. 1993 Dec; 44(6): 1298-308. PMID: 8301931, ISSN: 0085-2538.

de Caestecker MP, Telfer BA, Hutchinson IV, Ballardie FW. The detection of intracytoplasmic interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha expression in human monocytes using two colour immunofluorescence flow cytometry. J. Immunol. Methods. 1992 Sep 9/18/1992; 154(1): 11-20. PMID: 1401937, PII: 0022-1759(92)90207-A, ISSN: 0022-1759.

de Caestecker MP, Ballardie FW. Volumetric analysis of urinary erythrocytes: a standardized methodology to localize the source of haematuria. Am. J. Nephrol. 1992; 12(1-2): 41-8. PMID: 1415364, ISSN: 0250-8095.

de Caestecker MP, Ballardie FW. Unexplained haematuria [editorial]. BMJ. 1990 Nov 11/24/1990; 301(6762): 1171-2. PMID: 2261550, PMCID: PMC1664318, ISSN: 0959-8138.

de Caestecker MP, Hall CL, MacIver AG. Atypical antiglomerular basement membrane disease associated with thin membrane nephropathy. Nephrol. Dial. Transplant. 1990; 5(11): 909-13. PMID: 2127824, ISSN: 0931-0509.

de Caestecker MP, Hall CL, Basterfield PT, Smith JG. Localisation of haematuria by red cell analysers and phase contrast microscopy. Nephron. 1989; 52(2): 170-3. PMID: 2662043, ISSN: 1660-8151.

Available Postdoctoral Position Details
Posted Position

We are looking for a 1st or 2nd year postdoctoral fellow to start a new project studying the role and mechanisms by which retinoic acid signaling regulates cellular repair after kidney injury, and therapeutic manipulation of this pathway in disease. The studies will involve the use of genetically modified mice, kidney injury models, careful spatial and temporal analysis of retinoic acid signaling activities in the kidney, cell sorting, bone marrow transplantation, RNA seq etc. The applicant should have experience with mice, ideally studying kidney disease, immunology experience would also be a plus. Training in kidney disease models and pathophysiology provided through the Vanderbilt Center for Kidney Disease (VCKD). A secondary basic science appointment in the Department of Cell and Developmental Biology at Vanderbilt University, as well as training in molecular medicine with Vanderbilt Program in Molecular Medicine will be encouraged

10/29/2012 No new positions currently availlable