Catherine C. McGowan, M.D.

Associate Professor

c.mcgowan@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.D., Medicine, University of Kansas, Kansas City, KansasB.A., MAJOR: BIOCHEMISTRY, University of Kansas, Lawrence, Kansas
Office Address
A-2200 MCN
Infectious Diseases
TN 2582
Research Description
The main research focus of my lab is the pathogenesis of Helicobacter pylori. Specifically, my studies have examined acid-inducible gene expression in H. pylori. Using RNA subtractive-hybridizaiton, we have identified 28 genes whose expression is enhanced at acid pH. The genes are diverse, and appear to be involved in virulence and colonization, DNA protection and repair, cell wall structure, and gene regulation; several genes are of unknown function. Promoter analyses of these genes demonstrate that they are diverse, and under the control of several different regulators. Mechanisms of increased gene expression at low pH have been examined, and include enhanced utilization of specific promoters and increased stability of mRNA. Ongoing work includes mutagenesis studies of acid-induced genes, characterization of putative regulators, and more detailed analysis of acid-inducible promoters. . .
Research Keywords
Characterization of acid-induced gene expression in Helicobacter pylori
Publications
Luque MT, Jenkins CA, Shepherd BE, Padgett D, Rouzier V, Succi RC, Machado DM, McGowan CC, Vermund SH, Pinto JA. Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America. J. Pediatr [print-electronic]. 2017 Mar; 182: 245-252.e1. PMID: 28081884, PMCID: PMC5328796, PII: S0022-3476(16)31433-0, DOI: 10.1016/j.jpeds.2016.12.034, ISSN: 1097-6833.

Fritz CQ, Blevins M, Lindegren ML, Wools-Kaloutsian K, Musick BS, Cornell M, Goodwin K, Addison D, Dusingize JC, Messou E, Poda A, Duda SN, McGowan CC, Law MG, Moore RD, Freeman A, Nash D, Wester CW. Comprehensiveness of HIV care provided at global HIV treatment sites in the IeDEA consortium: 2009 and 2014. J Int AIDS Soc. 2017 Jan 1/6/2017; 20(1): 1-14. PMID: 28364561, PMCID: PMC5463912, DOI: 10.7448/IAS.20.1.20933, ISSN: 1758-2652.

Wolff MJ, Cortes CP, Mejìa FA, Padgett D, Belaunzarán-Zamudio P, Grinsztejn B, Giganti MJ, McGowan CC, Rebeiro PF, . Evaluating the care cascade after antiretroviral therapy initiation in Latin America. Int J STD AIDS [print-electronic]. 2017 Jan 1/1/2017; 956462417714094. PMID: 28618980, DOI: 10.1177/0956462417714094, ISSN: 1758-1052.

Wolff MJ, Giganti MJ, Cortes CP, Cahn P, Grinsztejn B, Pape JW, Padgett D, Sierra-Madero J, Gotuzzo E, Duda SN, McGowan CC, Shepherd BE, . A decade of HAART in Latin America: Long term outcomes among the first wave of HIV patients to receive combination therapy. PLoS ONE. 2017; 12(6): e0179769. PMID: 28651014, PMCID: PMC5484471, PII: PONE-D-16-50262, DOI: 10.1371/journal.pone.0179769, ISSN: 1932-6203.

De Boni RB, Shepherd BE, Grinsztejn B, Cesar C, Cortés C, Padgett D, Gotuzzo E, Belaunzarán-Zamudio PF, Rebeiro PF, Duda SN, McGowan CC. Substance Use and Adherence Among People Living with HIV/AIDS Receiving cART in Latin America. AIDS Behav. 2016 Nov; 20(11): 2692-9. PMID: 27091028, PMCID: PMC5069110, PII: 10.1007/s10461-016-1398-6, DOI: 10.1007/s10461-016-1398-6, ISSN: 1573-3254.

Rebeiro PF, Cesar C, Shepherd BE, De Boni RB, Cortés CP, Rodriguez F, Belaunzarán-Zamudio P, Pape JW, Padgett D, Hoces D, McGowan CC, Cahn P. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression. J Int AIDS Soc. 2016; 19(1): 20636. PMID: 27065108, PMCID: PMC4827101, PII: 20636, ISSN: 1758-2652.

Blevins M, Wehbe FH, Rebeiro PF, Caro-Vega Y, McGowan CC, Shepherd BE, . Interactive Data Visualization for HIV Cohorts: Leveraging Data Exchange Standards to Share and Reuse Research Tools. PLoS ONE. 2016; 11(3): e0151201. PMID: 26963255, PMCID: PMC4786152, PII: PONE-D-15-32410, DOI: 10.1371/journal.pone.0151201, ISSN: 1932-6203.

Wolff M, Shepherd BE, Cortés C, Rebeiro P, Cesar C, Wagner Cardoso S, Pape JW, Padgett D, Sierra-Madero J, Echevarria J, McGowan CC, . Clinical and Virologic Outcomes After Changes in First Antiretroviral Regimen at 7 Sites in the Caribbean, Central and South America Network. J. Acquir. Immune Defic. Syndr. 2016 Jan 1/1/2016; 71(1): 102-10. PMID: 26761273, PMCID: PMC4712722, PII: 00126334-201601010-00015, DOI: 10.1097/QAI.0000000000000817, ISSN: 1944-7884.

Giganti MJ, Luz PM, Caro-Vega Y, Cesar C, Padgett D, Koenig S, Echevarria J, McGowan CC, Shepherd BE. A Comparison of Seven Cox Regression-Based Models to Account for Heterogeneity Across Multiple HIV Treatment Cohorts in Latin America and the Caribbean. AIDS Res. Hum. Retroviruses [print-electronic]. 2015 May; 31(5): 496-503. PMID: 25647087, PMCID: PMC4426314, DOI: 10.1089/AID.2014.0241, ISSN: 1931-8405.

Luz PM, Belaunzarán-Zamudio PF, Crabtree-Ramírez B, Caro-Vega Y, Hoces D, Rebeiro PF, Blevins M, Pape JW, Cortes CP, Padgett D, Cahn P, Veloso VG, McGowan CC, Grinsztejn B, Shepherd BE. CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean. Open Forum Infect Dis. 2015 Apr; 2(2): ofv079. PMID: 26180829, PMCID: PMC4498272, PII: ofv079, DOI: 10.1093/ofid/ofv079, ISSN: 2328-8957.

Ballif M, Renner L, Claude Dusingize J, Leroy V, Ayaya S, Wools-Kaloustian K, Cortes CP, McGowan CC, Graber C, Mandalakas AM, Mofenson LM, Egger M, Kumara Wati KD, Nallusamy R, Reubenson G, Davies MA, Fenner L, , . Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices. J Pediatric Infect Dis Soc [print-electronic]. 2015 Mar; 4(1): 30-8. PMID: 26407355, PII: piu020, DOI: 10.1093/jpids/piu020, ISSN: 2048-7207.

Duda SN, McGowan CC, Gadd CS. Perceived Reasons for High and Low Quality Observational HIV Research Data. Stud Health Technol Inform. 2015; 216: 994. PMID: 26262296, PMCID: PMC4559484, ISSN: 0926-9630.

Carriquiry G, Fink V, Koethe JR, Giganti MJ, Jayathilake K, Blevins M, Cahn P, Grinsztejn B, Wolff M, Pape JW, Padgett D, Madero JS, Gotuzzo E, McGowan CC, Shepherd BE. Mortality and loss to follow-up among HIV-infected persons on long-term antiretroviral therapy in Latin America and the Caribbean. J Int AIDS Soc. 2015; 18: 20016. PMID: 26165322, PMCID: PMC4499577, PII: 20016, ISSN: 1758-2652.

Kipp AM, Audet CM, Earnshaw VA, Owens J, McGowan CC, Wallston KA. Re-validation of the Van Rie HIV/AIDS-related stigma scale for use with people living with HIV in the United States. PLoS ONE. 2015; 10(3): e0118836. PMID: 25738884, PMCID: PMC4349586, PII: PONE-D-13-50444, DOI: 10.1371/journal.pone.0118836, ISSN: 1932-6203.

Castilho JL, Luz PM, Shepherd BE, Turner M, Ribeiro SR, Bebawy SS, Netto JS, McGowan CC, Veloso VG, Engels EA, Sterling TR, Grinsztejn B. HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts. Infect. Agents Cancer. 2015; 10: 4. PMID: 25685180, PMCID: PMC4327947, PII: 514, DOI: 10.1186/1750-9378-10-4, ISSN: 1750-9378.

Ballif M, Nhandu V, Wood R, Dusingize JC, Carter EJ, Cortes CP, McGowan CC, Diero L, Graber C, Renner L, Hawerlander D, Kiertiburanakul S, Du QT, Sterling TR, Egger M, Fenner L, . Detection and management of drug-resistant tuberculosis in HIV-infected patients in lower-income countries. Int. J. Tuberc. Lung Dis. 2014 Nov; 18(11): 1327-36. PMID: 25299866, PMCID: PMC4323497, DOI: 10.5588/ijtld.14.0106, ISSN: 1815-7920.

Qian HZ, Mitchell VJ, Bebawy S, Cassell H, Perez G, McGowan CC, Sterling TR, Vermund SH, D'Aquila R, Hulgan T. Current drug use and lack of HIV virologic suppression: point-of-care urine drug screen versus self-report. BMC Infect. Dis. 2014 Sep 9/18/2014; 14: 508. PMID: 25234368, PMCID: PMC4175271, PII: 1471-2334-14-508, DOI: 10.1186/1471-2334-14-508, ISSN: 1471-2334.

Duda SN, Farr AM, Lindegren ML, Blevins M, Wester CW, Wools-Kaloustian K, Ekouevi DK, Egger M, Hemingway-Foday J, Cooper DA, Moore RD, McGowan CC, Nash D, . Characteristics and comprehensiveness of adult HIV care and treatment programmes in Asia-Pacific, sub-Saharan Africa and the Americas: results of a site assessment conducted by the International epidemiologic Databases to Evaluate AIDS (IeDEA) Collaboration. J Int AIDS Soc. 2014; 17: 19045. PMID: 25516092, PMCID: PMC4268491, PII: 19045, ISSN: 1758-2652.

Cesar C, Shepherd BE, Jenkins CA, Ghidinelli M, Castro JL, Veloso VG, Cortes CP, Padgett D, Crabtree-Ramirez B, Gotuzzo E, Fink V, Duran A, Sued O, McGowan CC, Cahn P, . Use of third line antiretroviral therapy in Latin America. PLoS ONE. 2014; 9(9): e106887. PMID: 25221931, PMCID: PMC4164470, PII: PONE-D-14-14529, DOI: 10.1371/journal.pone.0106887, ISSN: 1932-6203.

Audet CM, McGowan CC, Wallston KA, Kipp AM. Relationship between HIV stigma and self-isolation among people living with HIV in Tennessee. PLoS ONE. 2013; 8(8): e69564. PMID: 23950897, PMCID: PMC3738573, PII: PONE-D-13-00485, DOI: 10.1371/journal.pone.0069564, ISSN: 1932-6203.

Rasbach DA, Desruisseau AJ, Kipp AM, Stinnette S, Kheshti A, Shepherd BE, Sterling TR, Hulgan T, McGowan CC, Qian HZ. Active cocaine use is associated with lack of HIV-1 virologic suppression independent of nonadherence to antiretroviral therapy: use of a rapid screening tool during routine clinic visits. AIDS Care [print-electronic]. 2013; 25(1): 109-17. PMID: 22670566, PMCID: PMC3443534, DOI: 10.1080/09540121.2012.687814, ISSN: 1360-0451.

Parrish DD, Blevins M, Stinnette SE, Rebeiro PF, Shepherd BE, Sterling TR, McGowan CC, Wester CW. Virologic, immunologic and clinical responses in foreign-born versus US-born HIV-1 infected adults initiating antiretroviral therapy: an observational cohort study. PLoS ONE [print-electronic]. 2012; 7(12): e52336. PMID: 23284994, PMCID: PMC3526482, PII: PONE-D-12-30873, DOI: 10.1371/journal.pone.0052336, ISSN: 1932-6203.

Duda SN, Shepherd BE, Gadd CS, Masys DR, McGowan CC. Measuring the quality of observational study data in an international HIV research network. PLoS ONE [print-electronic]. 2012; 7(4): e33908. PMID: 22493676, PMCID: PMC3320898, PII: PONE-D-11-15552, DOI: 10.1371/journal.pone.0033908, ISSN: 1932-6203.

Wester CW, Koethe JR, Shepherd BE, Stinnette SE, Rebeiro PF, Kipp AM, Hong H, Bussmann H, Gaolathe T, McGowan CC, Sterling TR, Marlink RG. Non-AIDS-defining events among HIV-1-infected adults receiving combination antiretroviral therapy in resource-replete versus resource-limited urban setting. AIDS. 2011 Jul 7/31/2011; 25(12): 1471-9. PMID: 21572309, PMCID: PMC3188442, DOI: 10.1097/QAD.0b013e328347f9d4, ISSN: 1473-5571.

Qian HZ, Stinnette SE, Rebeiro PF, Kipp AM, Shepherd BE, Samenow CP, Jenkins CA, No P, McGowan CC, Hulgan T, Sterling TR. The relationship between injection and noninjection drug use and HIV disease progression. J Subst Abuse Treat [print-electronic]. 2011 Jul; 41(1): 14-20. PMID: 21349679, PMCID: PMC3110534, PII: S0740-5472(11)00014-6, DOI: 10.1016/j.jsat.2011.01.007, ISSN: 1873-6483.

McGowan CC, Weinstein DD, Samenow CP, Stinnette SE, Barkanic G, Rebeiro PF, Sterling TR, Moore RD, Hulgan T. Drug use and receipt of highly active antiretroviral therapy among HIV-infected persons in two U.S. clinic cohorts. PLoS ONE. 2011 Apr 4/25/2011; 6(4): e18462. PMID: 21541016, PMCID: PMC3081810, DOI: 10.1371/journal.pone.0018462, ISSN: 1932-6203.

Shepherd BE, Jenkins CA, Rebeiro PF, Stinnette SE, Bebawy SS, McGowan CC, Hulgan T, Sterling TR. Estimating the optimal CD4 count for HIV-infected persons to start antiretroviral therapy. Epidemiology. 2010 Sep; 21(5): 698-705. PMID: 20585252, PMCID: PMC3086582, DOI: 10.1097/EDE.0b013e3181e97737, ISSN: 1531-5487.

McGowan CC, Cahn P, Gotuzzo E, Padgett D, Pape JW, Wolff M, Schechter M, Masys DR. Cohort Profile: Caribbean, Central and South America Network for HIV research (CCASAnet) collaboration within the International Epidemiologic Databases to Evaluate AIDS (IeDEA) programme. Int J Epidemiol [print-electronic]. 2007 Oct; 36(5): 969-76. PMID: 17846055, PII: dym073, DOI: 10.1093/ije/dym073, ISSN: 0300-5771.

McGowan CC, Necheva AS, Forsyth MH, Cover TL, Blaser MJ. Promoter analysis of Helicobacter pylori genes with enhanced expression at low pH. Mol. Microbiol. 2003 Jun; 48(5): 1225-39. PMID: 12787351, PII: 3500, ISSN: 0950-382X.

McGowan, CC, Necheva, AS, Forsyth, MH, Cover, TL, and Blaser, MJ. Promoter analysis of Helicobacter pylori genes with enhanced expression at low pH. Molec Microbiol. 2003; 48((5)): 1225-39.

McGowan CC, Necheva A, Thompson SA, Cover TL, Blaser MJ. Acid-induced expression of an LPS-associated gene in Helicobacter pylori. Mol. Microbiol. 1998 Oct; 30(1): 19-31. PMID: 9786182, ISSN: 0950-382X.

Mc Gowan, CC, Necheva, AS, Thompson, SA, Cover, TL, and Blaser, MJ. Acid-induced expression of an LPS-associated gene in Helicobacter pylori. Molec Microbiol. 1998; 30((1)): 19-31.

McGowan CC, Cover TL, Blaser MJ. Analysis of F1F0-ATPase from Helicobacter pylori. Infect. Immun. 1997 Jul; 65(7): 2640-7. PMID: 9199431, PMCID: PMC175373, ISSN: 0019-9567.

McGowan, CC, Cover, TL, and Blaser MJ. Analysis of F1F0-ATPase from Helicobacter pylori. Infect Immun. 1997; 65((7)): 2640-7.

McGowan CC, Cover TL, Blaser MJ. Helicobacter pylori and gastric acid: biological and therapeutic implications. Gastroenterology. 1996 Mar; 110(3): 926-38. PMID: 8608904, PII: S0016508596001394, ISSN: 0016-5085.

McGowan CC, Cover TL, and Blaser MJ. Helicobacter pylori and gastric acid: biological and therapeutic implications. Gastroenterology. 1996; 110: 926-38.

McGowan CC, Cover TL, Blaser MJ. The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. Gastroenterology. 1994 Nov; 107(5): 1573-8. PMID: 7926527, PII: S0016508594003501, ISSN: 0016-5085.

McGowan CC, Cover TL, Blaser MJ. The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. Gastroenterology. 1994 Sep; 107(3): 738-43. PMID: 8076759, ISSN: 0016-5085.

McGowan CC, Cover TL, and Blaser MJ. The proton pump inhibitor, omeprazole, inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. Gastroenterology. 1994; 107: 1573-8.