S. Kent Dickeson, Ph.D.

Research Assistant Professor

stephen.k.dickeson@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Biochemistry, University of Kansas, Lawrence, KansasB.S., Chemistry, Missouri State University, Springfield, Missouri
Office Address
4918 TVC 5310
1301 Medical Center Dr.
Nashville, TN 37232
Research Description
Investigating the role of Factor XI in coagulation and thrombosis.
Research Keywords
coagulation, Factor XI, collagen, platelet, integrin, I domain, extracellular matrix, cell adhesion, aggregation, MIDAS, collectin
Publications
Ivanov I, Shakhawat R, Sun MF, Dickeson SK, Puy C, McCarty OJ, Gruber A, Matafonov A, Gailani D. Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen. Thromb. Haemost [print-electronic]. 2017 Apr 4/3/2017; 117(4): 671-81. PMID: 28124063, PII: 16-09-0691, DOI: 10.1160/TH16-09-0691, ISSN: 0340-6245.

Ivanov I, Matafonov A, Sun MF, Cheng Q, Dickeson SK, Verhamme IM, Emsley J, Gailani D. Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation. Blood [print-electronic]. 2017 Mar 3/16/2017; 129(11): 1527-37. PMID: 28069606, PMCID: PMC5356457, PII: blood-2016-10-744110, DOI: 10.1182/blood-2016-10-744110, ISSN: 1528-0020.

Parham CL, Shaw C, Auckland LD, Dickeson SK, Griswold-Prenner I, Bix G. Perlecan Domain V Inhibits Amyloid-ß Induced Activation of the a2ß1 Integrin-Mediated Neurotoxic Signaling Cascade. J. Alzheimers Dis. 2016 Oct 10/18/2016; 54(4): 1629-47. PMID: 27636841, PII: JAD160290, DOI: 10.3233/JAD-160290, ISSN: 1875-8908.

Kokoye Y, Ivanov I, Cheng Q, Matafonov A, Dickeson SK, Mason S, Sexton DJ, Renné T, McCrae K, Feener EP, Gailani D. A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation. Thromb. Res [print-electronic]. 2016 Feb 2/18/2016; 140: 118-24. PMID: 26950760, PII: S0049-3848(16)30047-0, DOI: 10.1016/j.thromres.2016.02.020, ISSN: 1879-2472.

Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM. Mitigation of oxygen-induced retinopathy in a2ß1 integrin-deficient mice. Invest. Ophthalmol. Vis. Sci. 2014 Jul; 55(7): 4338-47. PMID: 24917135, PMCID: PMC4102391, PII: iovs.14-14061, DOI: 10.1167/iovs.14-14061, ISSN: 1552-5783.

Marjoram RJ, Li Z, He L, Tollefsen DM, Kunicki TJ, Dickeson SK, Santoro SA, Zutter MM. A2ß1 integrin, GPVI receptor, and common FcR¿ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis. PLoS ONE. 2014; 9(11): e114035. PMID: 25415203, PMCID: PMC4240667, PII: PONE-D-13-16579, DOI: 10.1371/journal.pone.0114035, ISSN: 1932-6203.

Wright S, Parham C, Lee B, Clarke D, Auckland L, Johnston J, Lawrence AL, Dickeson SK, Santoro SA, Griswold-Prenner I, Bix G. Perlecan domain V inhibits a2 integrin-mediated amyloid-ß neurotoxicity. Neurobiol. Aging [print-electronic]. 2012 Jul; 33(7): 1379-88. PMID: 21126803, PII: S0197-4580(10)00463-X, DOI: 10.1016/j.neurobiolaging.2010.10.018, ISSN: 1558-1497.

Tran T, Barlow B, O'Rear L, Jarvis B, Li Z, Dickeson K, Dupont W, Zutter M. Loss of the a2ß1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro. PLoS ONE [print-electronic]. 2011; 6(10): e26858. PMID: 22046385, PMCID: PMC3203166, PII: PONE-D-11-08237, DOI: 10.1371/journal.pone.0026858, ISSN: 1932-6203.

Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA. Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen. J. Biol. Chem [print-electronic]. 2009 Dec 12/11/2009; 284(50): 34640-7. PMID: 19815553, PMCID: PMC2787326, PII: M109.020990, DOI: 10.1074/jbc.M109.020990, ISSN: 1083-351X.

Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, Stricker TP, Santoro SA, Kahn ML. Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood [print-electronic]. 2009 Jun 6/18/2009; 113(25): 6428-39. PMID: 19258597, PII: blood-2008-08-175356, DOI: 10.1182/blood-2008-08-175356, ISSN: 1528-0020.

Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM, Nemerow GR, Bergelson JM, Dermody TS. Beta1 integrin mediates internalization of mammalian reovirus. J. Virol. 2006 Mar; 80(6): 2760-70. PMID: 16501085, PMCID: PMC1395463, PII: 80/6/2760, DOI: 10.1128/JVI.80.6.2760-2770.2006, ISSN: 0022-538X.

Edelson BT, Stricker TP, Li Z, Dickeson SK, Shepherd VL, Santoro SA, Zutter MM. Novel collectin/C1q receptor mediates mast cell activation and innate immunity. Blood [print-electronic]. 2006 Jan 1/1/2006; 107(1): 143-50. PMID: 16166590, PMCID: PMC1895357, PII: 2005-06-2218, DOI: 10.1182/blood-2005-06-2218, ISSN: 0006-4971.

Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen. J. Biol. Chem [print-electronic]. 2001 Aug 8/3/2001; 276(31): 29368-74. PMID: 11359786, PII: M104179200, DOI: 10.1074/jbc.M104179200, ISSN: 0021-9258.

Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA. Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction. J. Biol. Chem [print-electronic]. 2001 Aug 8/3/2001; 276(31): 29375-81. PMID: 11359774, PII: M102217200, DOI: 10.1074/jbc.M102217200, ISSN: 0021-9258.

Ohman T, King SL, Krithivas A, Cunningham J, Dickeson SK, Santoro SA, Bergelson JM. Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain. Virus Res. 2001 Jul; 76(1): 1-8. PMID: 11376841, PII: S0168-1702(01)00226-X, ISSN: 0168-1702.

Ding Q, Gladson CL, Guidry CR, Santoro SA, Dickeson SK, Shin JT, Thompson JA. Extracellular FGF-1 inhibits cytoskeletal organization and promotes fibroblast motility. Growth Factors. 2000; 18(2): 93-107. PMID: 11019781, ISSN: 0897-7194.

Dickeson SK, Mathis NL, Rahman M, Bergelson JM, Santoro SA. Determinants of ligand binding specificity of the alpha(1)beta(1) and alpha(2)beta(1) integrins. J. Biol. Chem. 1999 Nov 11/5/1999; 274(45): 32182-91. PMID: 10542255, ISSN: 0021-9258.

Zutter MM, Santoro SA, Wu JE, Wakatsuki T, Dickeson SK, Elson EL. Collagen receptor control of epithelial morphogenesis and cell cycle progression. Am. J. Pathol. 1999 Sep; 155(3): 927-40. PMID: 10487850, PMCID: PMC1866884, PII: S0002-9440(10)65192-9, DOI: 10.1016/S0002-9440(10)65192-9, ISSN: 0002-9440.

Dickeson SK, Bhattacharyya-Pakrasi M, Mathis NL, Schlesinger PH, Santoro SA. Ligand binding results in divalent cation displacement from the alpha 2 beta 1 integrin I domain: evidence from terbium luminescence spectroscopy. Biochemistry. 1998 Aug 8/11/1998; 37(32): 11280-8. PMID: 9698375, PII: bi9727848, DOI: 10.1021/bi9727848, ISSN: 0006-2960.

Bhattacharyya-Pakrasi M, Dickeson SK, Santoro SA. Alpha2beta1 integrin recognition of the carboxyl-terminal propeptide of type I procollagen: integrin recognition and feed-back regulation of matrix biosynthesis are mediated by distinct sequences. Matrix Biol. 1998 Jul; 17(3): 223-32. PMID: 9707345, ISSN: 0945-053X.

Dickeson SK, Walsh JJ, Santoro SA. Binding of the alpha 2 integrin I domain to extracellular matrix ligands: structural and mechanistic differences between collagen and laminin binding. Cell Adhes. Commun. 1998 Jun; 5(4): 273-81. PMID: 9762468, ISSN: 1061-5385.

Dickeson SK, Santoro SA. Ligand recognition by the I domain-containing integrins. Cell. Mol. Life Sci. 1998 Jun; 54(6): 556-66. PMID: 9676575, ISSN: 1420-682X.

Dickeson SK, Walsh JJ, Santoro SA. Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrin. J. Biol. Chem. 1997 Mar 3/21/1997; 272(12): 7661-8. PMID: 9065422, ISSN: 0021-9258.

Dickeson SK, Helmkamp GM, Yarbrough LR. Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes. Gene. 1994 May 5/16/1994; 142(2): 301-5. PMID: 8194769, ISSN: 0378-1119.

Dickeson SK, Lim CN, Schuyler GT, Dalton TP, Helmkamp GM, Yarbrough LR. Isolation and sequence of cDNA clones encoding rat phosphatidylinositol transfer protein. J. Biol. Chem. 1989 Oct 10/5/1989; 264(28): 16557-64. PMID: 2777797, ISSN: 0021-9258.