Todd W. Rice, M.D.

Associate Professor

todd.rice@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.D., MEDICINE MD, Indiana University, Indianapolis, IndianaB.S., University of Notre Dame, South Bend, Indiana
Office Address
T-1218 MCN
Nashville, TN 2650
Publications
Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax [print-electronic]. 2018 Jun 6/14/2018; PMID: 29903755, PII: thoraxjnl-2017-211280, DOI: 10.1136/thoraxjnl-2017-211280, ISSN: 1468-3296.

McKown AC, Huerta LE, Rice TW, Semler MW, . Heterogeneity of Treatment Effect by Baseline Risk in a Trial of Balanced Crystalloids versus Saline. Am. J. Respir. Crit. Care Med [print-electronic]. 2018 Jun 6/13/2018; PMID: 29897785, DOI: 10.1164/rccm.201804-0680LE, ISSN: 1535-4970.

Janz DR, Semler MW, Casey JD, Joffe AM, Rice TW. Response [letter]. Chest. 2018 Jun; 153(6): 1506. PMID: 29884260, PII: S0012-3692(18)30411-2, DOI: 10.1016/j.chest.2018.03.004, ISSN: 1931-3543.

Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Eur. Respir. J [electronic-print]. 2018 Jun; 51(6): PMID: 29903860, PII: 13993003.02638-2017, DOI: 10.1183/13993003.02638-2017, ISSN: 1399-3003.

Malbrain MLNG, Van Regenmortel N, Saugel B, De Tavernier B, Van Gaal PJ, Joannes-Boyau O, Teboul JL, Rice TW, Mythen M, Monnet X. Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy. Ann Intensive Care. 2018 May 5/22/2018; 8(1): 66. PMID: 29789983, PMCID: PMC5964054, PII: 10.1186/s13613-018-0402-x, DOI: 10.1186/s13613-018-0402-x, ISSN: 2110-5820.

Semler MW, Self WH, Rice TW. Balanced Crystalloids versus Saline in Critically Ill Adults [letter]. N. Engl. J. Med. 2018 May 5/17/2018; 378(20): 1951. PMID: 29768150, PII: 10.1056/NEJMc1804294#SA5, DOI: 10.1056/NEJMc1804294, ISSN: 1533-4406.

Semler MW, Self WH, Wang L, Bernard GR, Rice TW, . Reply to Vincent and De Backer: We Do Not Appreciate SALT. Am. J. Respir. Crit. Care Med. 2018 May 5/15/2018; 197(10): 1362. PMID: 29509507, PMCID: PMC5955063, DOI: 10.1164/rccm.201803-0392LE, ISSN: 1535-4970.

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI, . Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Ann Emerg Med [print-electronic]. 2018 May 5/9/2018; PMID: 29753517, PII: S0196-0644(18)30315-9, DOI: 10.1016/j.annemergmed.2018.03.039, ISSN: 1097-6760.

McKown AC, Semler MW, Rice TW. Best PEEP trials are dependent on tidal volume [letter]. Crit Care. 2018 May 5/2/2018; 22(1): 115. PMID: 29720277, PMCID: PMC5930668, PII: 10.1186/s13054-018-2047-4, DOI: 10.1186/s13054-018-2047-4, ISSN: 1466-609X.

Janz DR, Semler MW, Joffe AM, Casey JD, Lentz RJ, deBoisblanc BP, Khan YA, Santanilla JI, Bentov I, Rice TW, , . A Multicenter Randomized Trial of a Checklist for Endotracheal Intubation of Critically Ill Adults. Chest [print-electronic]. 2018 Apr; 153(4): 816-24. PMID: 28917549, PMCID: PMC5989637, PII: S0012-3692(17)32685-5, DOI: 10.1016/j.chest.2017.08.1163, ISSN: 1931-3543.

Beavers JR, Stollings JL, Rice TW. Association between hyperinsulinemia-euglycemia therapy and hyponatremia [letter]. Am J Health Syst Pharm. 2018 Apr 4/1/2018; 75(7): 422. PMID: 29572309, PII: 75/7/422, DOI: 10.2146/ajhp170898, ISSN: 1535-2900.

Janz DR, Semler MW, Casey JD, Joffe AM, Rice TW. Response [letter]. Chest. 2018 Apr; 153(4): 1076-7. PMID: 29626955, PII: S0012-3692(17)33195-1, DOI: 10.1016/j.chest.2017.11.021, ISSN: 1931-3543.

McKown AC, Semler MW, Rice TW. Lung Recruitment and Positive End-Expiratory Pressure Titration in Patients With Acute Respiratory Distress Syndrome [letter]. JAMA. 2018 Mar 3/6/2018; 319(9): 932-3. PMID: 29509861, PII: 2673963, DOI: 10.1001/jama.2017.21856, ISSN: 1538-3598.

Self WH, Semler MW, Wanderer JP, Wang L, Byrne DW, Collins SP, Slovis CM, Lindsell CJ, Ehrenfeld JM, Siew ED, Shaw AD, Bernard GR, Rice TW, . Balanced Crystalloids versus Saline in Noncritically Ill Adults. N. Engl. J. Med [print-electronic]. 2018 Mar 3/1/2018; 378(9): 819-28. PMID: 29485926, PMCID: PMC5846618, DOI: 10.1056/NEJMoa1711586, ISSN: 1533-4406.

Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, Stollings JL, Kumar AB, Hughes CG, Hernandez A, Guillamondegui OD, May AK, Weavind L, Casey JD, Siew ED, Shaw AD, Bernard GR, Rice TW, . Balanced Crystalloids versus Saline in Critically Ill Adults. N. Engl. J. Med [print-electronic]. 2018 Mar 3/1/2018; 378(9): 829-39. PMID: 29485925, PMCID: PMC5846085, DOI: 10.1056/NEJMoa1711584, ISSN: 1533-4406.

Stollings JL, Landsperger JS, Semler MW, Rice TW. Tranexamic acid for refractory gastrointestinal bleeds: A cohort study. J Crit Care [print-electronic]. 2018 Feb; 43: 128-32. PMID: 28889070, PMCID: PMC5732862, PII: S0883-9441(17)30772-4, DOI: 10.1016/j.jcrc.2017.08.035, ISSN: 1557-8615.

Semler MW, Casey JD, Janz DR, Russell DW, Rice TW. Response [letter]. Chest. 2018 Feb; 153(2): 568-9. PMID: 29406220, PII: S0012-3692(17)33196-3, DOI: 10.1016/j.chest.2017.11.022, ISSN: 1931-3543.

Semler MW, Janz DR, Casey JD, Russell DW, Rice TW. Response [letter]. Chest. 2017 Dec; 152(6): 1351. PMID: 29223265, PII: S0012-3692(17)32870-2, DOI: 10.1016/j.chest.2017.09.032, ISSN: 1931-3543.

Semler MW, Janz DR, Casey JD, Russell DW, Rice TW. Response [letter]. Chest. 2017 Nov; 152(5): 1092-3. PMID: 29126526, PII: S0012-3692(17)31310-7, DOI: 10.1016/j.chest.2017.07.017, ISSN: 1931-3543.

Semler MW, Janz DR, Russell DW, Casey JD, Lentz RJ, Zouk AN, deBoisblanc BP, Santanilla JI, Khan YA, Joffe AM, Stigler WS, Rice TW, , . A Multicenter, Randomized Trial of Ramped Position vs Sniffing Position During Endotracheal Intubation of Critically Ill Adults. Chest [print-electronic]. 2017 Oct; 152(4): 712-22. PMID: 28487139, PMCID: PMC5812765, PII: S0012-3692(17)30881-4, DOI: 10.1016/j.chest.2017.03.061, ISSN: 1931-3543.

Arabi YM, Casaer MP, Chapman M, Heyland DK, Ichai C, Marik PE, Martindale RG, McClave SA, Preiser JC, Reignier J, Rice TW, Van den Berghe G, van Zanten ARH, Weijs PJM. The intensive care medicine research agenda in nutrition and metabolism. Intensive Care Med [print-electronic]. 2017 Sep; 43(9): 1239-56. PMID: 28374096, PMCID: PMC5569654, PII: 10.1007/s00134-017-4711-6, DOI: 10.1007/s00134-017-4711-6, ISSN: 1432-1238.

McKown AC, Wang L, Wanderer JP, Ehrenfeld J, Rice TW, Bernard GR, Semler MW. Predicting Major Adverse Kidney Events among Critically Ill Adults Using the Electronic Health Record. J Med Syst. 2017 Aug 8/31/2017; 41(10): 156. PMID: 28861688, PMCID: PMC5821255, PII: 10.1007/s10916-017-0806-4, DOI: 10.1007/s10916-017-0806-4, ISSN: 1573-689X.

Brown SM, Duggal A, Hou PC, Tidswell M, Khan A, Exline M, Park PK, Schoenfeld DA, Liu M, Grissom CK, Moss M, Rice TW, Hough CL, Rivers E, Thompson BT, Brower RG, . Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study. Crit. Care Med. 2017 Aug; 45(8): 1317-24. PMID: 28538439, PMCID: PMC5511089, DOI: 10.1097/CCM.0000000000002514, ISSN: 1530-0293.

Beavers JR, Stollings JL, Rice TW. Hyponatremia induced by hyperinsulinemia-euglycemia therapy. Am J Health Syst Pharm. 2017 Jul 7/15/2017; 74(14): 1062-6. PMID: 28687552, PII: 74/14/1062, DOI: 10.2146/ajhp160262, ISSN: 1535-2900.

Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, Wang L, Byrne DW, Shaw AD, Bernard GR, Rice TW, , . Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial. Am. J. Respir. Crit. Care Med. 2017 May 5/15/2017; 195(10): 1362-72. PMID: 27749094, PMCID: PMC5443900, DOI: 10.1164/rccm.201607-1345OC, ISSN: 1535-4970.

McKown AC, McGuinn EM, Ware LB, Wang L, Janz DR, Rice TW, Semler MW. Preadmission Oral Corticosteroids Are Associated With Reduced Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults With Sepsis. Crit. Care Med. 2017 May; 45(5): 774-80. PMID: 28257336, PMCID: PMC5392158, DOI: 10.1097/CCM.0000000000002286, ISSN: 1530-0293.

Self WH, Semler MW, Wanderer JP, Ehrenfeld JM, Byrne DW, Wang L, Atchison L, Felbinger M, Jones ID, Russ S, Shaw AD, Bernard GR, Rice TW. Saline versus balanced crystalloids for intravenous fluid therapy in the emergency department: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Apr 4/13/2017; 18(1): 178. PMID: 28407811, PMCID: PMC5390477, PII: 10.1186/s13063-017-1923-6, DOI: 10.1186/s13063-017-1923-6, ISSN: 1745-6215.

Janz DR, Semler MW, Rice TW. The authors reply. Crit. Care Med. 2017 Apr; 45(4): e463. PMID: 28291113, PMCID: PMC5358806, PII: 00003246-201704000-00052, DOI: 10.1097/CCM.0000000000002270, ISSN: 1530-0293.

Janz DR, Semler MW, Rice TW. The authors reply. Crit. Care Med. 2017 Apr; 45(4): e461. PMID: 28291111, PMCID: PMC5358803, PII: 00003246-201704000-00050, DOI: 10.1097/CCM.0000000000002271, ISSN: 1530-0293.

Semler MW, Self WH, Wang L, Byrne DW, Wanderer JP, Ehrenfeld JM, Stollings JL, Kumar AB, Hernandez A, Guillamondegui OD, May AK, Siew ED, Shaw AD, Bernard GR, Rice TW, , . Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Mar 3/16/2017; 18(1): 129. PMID: 28302179, PMCID: PMC5356286, PII: 10.1186/s13063-017-1871-1, DOI: 10.1186/s13063-017-1871-1, ISSN: 1745-6215.

Marik PE, Rice TW. Feeding the Critically Ill: More Questions Than Answers!. Am. J. Respir. Crit. Care Med. 2017 Mar 3/1/2017; 195(5): 555-6. PMID: 28248150, DOI: 10.1164/rccm.201609-1850ED, ISSN: 1535-4970.

Janz DR, Semler MW, Rice TW. The authors reply. Crit. Care Med. 2017 Mar; 45(3): e326-e327. PMID: 28212228, PMCID: PMC5347467, PII: 00003246-201703000-00034, DOI: 10.1097/CCM.0000000000002216, ISSN: 1530-0293.

Upchurch CP, Grijalva CG, Russ S, Collins SP, Semler MW, Rice TW, Liu D, Ehrenfeld JM, High K, Barrett TW, McNaughton CD, Self WH. Comparison of Etomidate and Ketamine for Induction During Rapid Sequence Intubation of Adult Trauma Patients. Ann Emerg Med. 2017 Jan; 69(1): 24-33.e2. PMID: 27993308, PMCID: PMC5180365, PII: S0196-0644(16)30467-X, DOI: 10.1016/j.annemergmed.2016.08.009, ISSN: 1097-6760.

Luyt CE, Rice TW. Co-infection in severe influenza: a new epidemiology? [editorial]. Intensive Care Med [print-electronic]. 2017 Jan; 43(1): 107-9. PMID: 27798740, PII: 10.1007/s00134-016-4597-8, DOI: 10.1007/s00134-016-4597-8, ISSN: 1432-1238.

Wu JY, Stollings JL, Wheeler AP, Semler MW, Rice TW. Efficacy and Outcomes After Vasopressin Guideline Implementation in Septic Shock. Ann Pharmacother [print-electronic]. 2017 Jan; 51(1): 13-20. PMID: 27630192, PII: 1060028016669163, DOI: 10.1177/1060028016669163, ISSN: 1542-6270.

Janz DR, Khan YA, Mooney JL, Semler MW, Rice TW, Johnson JL, deBoisblanc BP, . Effect of Interhospital ICU Relocation on Patient Physiology and Clinical Outcomes. J Intensive Care Med [print-electronic]. 2017 Jan 1/1/2017; 885066617726754. PMID: 28820040, DOI: 10.1177/0885066617726754, ISSN: 1525-1489.

Janz DR, Semler MW, Lentz RJ, Matthews DT, Assad TR, Norman BC, Keriwala RD, Ferrell BA, Noto MJ, Shaver CM, Richmond BW, Zinggeler Berg J, Rice TW, . Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults. Crit. Care Med. 2016 Nov; 44(11): 1980-7. PMID: 27355526, PMCID: PMC5203695, DOI: 10.1097/CCM.0000000000001841, ISSN: 1530-0293.

Stollings JL, Wheeler AP, Rice TW. Incidence and characterization of acute kidney injury after acetaminophen overdose. J Crit Care [print-electronic]. 2016 Oct; 35: 191-4. PMID: 27481758, PII: S0883-9441(16)30126-5, DOI: 10.1016/j.jcrc.2016.06.004, ISSN: 1557-8615.

Semler MW, Rice TW. Saline Is Not the First Choice for Crystalloid Resuscitation Fluids. Crit. Care Med. 2016 Aug; 44(8): 1541-4. PMID: 27428117, PMCID: PMC4955703, PII: 00003246-201608000-00013, DOI: 10.1097/CCM.0000000000001941, ISSN: 1530-0293.

Brown SM, Grissom CK, Moss M, Rice TW, Schoenfeld D, Hou PC, Thompson BT, Brower RG, . Nonlinear Imputation of Pao2/Fio2 From Spo2/Fio2 Among Patients With Acute Respiratory Distress Syndrome. Chest [print-electronic]. 2016 Aug; 150(2): 307-13. PMID: 26836924, PMCID: PMC4980543, PII: S0012-3692(16)00458-X, DOI: 10.1016/j.chest.2016.01.003, ISSN: 1931-3543.

Semler MW, Rice TW, Shaw AD, Siew ED, Self WH, Kumar AB, Byrne DW, Ehrenfeld JM, Wanderer JP. Identification of Major Adverse Kidney Events Within the Electronic Health Record. J Med Syst [print-electronic]. 2016 Jul; 40(7): 167. PMID: 27234478, PMCID: PMC5791539, PII: 10.1007/s10916-016-0528-z, DOI: 10.1007/s10916-016-0528-z, ISSN: 1573-689X.

Semler MW, Marney AM, Rice TW, Nian H, Yu C, Wheeler AP, Brown NJ, . B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS. Chest [print-electronic]. 2016 Jul; 150(1): 102-11. PMID: 27018313, PMCID: PMC4980545, PII: S0012-3692(16)45714-4, DOI: 10.1016/j.chest.2016.03.017, ISSN: 1931-3543.

Semler MW, Janz DR, Rice TW. Reply: Apneic Oxygenation Has Not Been Disproven. Am. J. Respir. Crit. Care Med. 2016 Jun 6/1/2016; 193(11): 1316-7. PMID: 27248595, PMCID: PMC4910906, DOI: 10.1164/rccm.201603-0604LE, ISSN: 1535-4970.

Semler MW, Rice TW. Sepsis Resuscitation: Fluid Choice and Dose. Clin. Chest Med [print-electronic]. 2016 Jun; 37(2): 241-50. PMID: 27229641, PMCID: PMC4884304, PII: S0272-5231(16)30006-5, DOI: 10.1016/j.ccm.2016.01.007, ISSN: 1557-8216.

Herridge MS, Moss M, Hough CL, Hopkins RO, Rice TW, Bienvenu OJ, Azoulay E. Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med [print-electronic]. 2016 May; 42(5): 725-38. PMID: 27025938, PII: 10.1007/s00134-016-4321-8, DOI: 10.1007/s00134-016-4321-8, ISSN: 1432-1238.

Semler MW, Wheeler AP, Thompson BT, Bernard GR, Wiedemann HP, Rice TW, . Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. Crit. Care Med. 2016 Apr; 44(4): 782-9. PMID: 26741580, PMCID: PMC4792704, DOI: 10.1097/CCM.0000000000001555, ISSN: 1530-0293.

Murray TS, Rice TW, Wheeler AP, Phillips EJ, Dworski RT, Stollings JL. Medication Desensitization: Characterization of Outcomes and Risk Factors for Reactions. Ann Pharmacother [print-electronic]. 2016 Mar; 50(3): 203-8. PMID: 26783356, PII: 1060028015625660, DOI: 10.1177/1060028015625660, ISSN: 1542-6270.

McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C, , . Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2016 Feb; 40(2): 159-211. PMID: 26773077, PII: 40/2/159, DOI: 10.1177/0148607115621863.

Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C, , . Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). Crit. Care Med. 2016 Feb; 44(2): 390-438. PMID: 26771786, PII: 00003246-201602000-00020, DOI: 10.1097/CCM.0000000000001525, ISSN: 1530-0293.

Semler MW, Janz DR, Lentz RJ, Matthews DT, Norman BC, Assad TR, Keriwala RD, Ferrell BA, Noto MJ, McKown AC, Kocurek EG, Warren MA, Huerta LE, Rice TW, , . Randomized Trial of Apneic Oxygenation during Endotracheal Intubation of the Critically Ill. Am. J. Respir. Crit. Care Med. 2016 Feb 2/1/2016; 193(3): 273-80. PMID: 26426458, PMCID: PMC4803060, DOI: 10.1164/rccm.201507-1294OC, ISSN: 1535-4970.

LaVie KW, Anderson SW, O'Neal HR, Rice TW, Saavedra TC, O'Neal CS. Neutropenia Associated with Long-Term Ceftaroline Use. Antimicrob. Agents Chemother [electronic-print]. 2016 Jan; 60(1): 264-9. PMID: 26503657, PMCID: PMC4704231, PII: AAC.01471-15, DOI: 10.1128/AAC.01471-15, ISSN: 1098-6596.

Taylor B, Rice TW. Must Our Malnourished Patients Eat Right or Die?. Crit. Care Med. 2015 Dec; 43(12): 2689-91. PMID: 26575662, PII: 00003246-201512000-00027, DOI: 10.1097/CCM.0000000000001338, ISSN: 1530-0293.

O'Rourke PP, Carrithers J, Patrick-Lake B, Rice TW, Corsmo J, Hart R, Drezner MK, Lantos JD. Harmonization and streamlining of research oversight for pragmatic clinical trials. Clin Trials [print-electronic]. 2015 Oct; 12(5): 449-56. PMID: 26374678, PMCID: PMC4592396, PII: 1740774515597685, DOI: 10.1177/1740774515597685, ISSN: 1740-7753.

Semler MW, Rice TW, Ehrenfeld JM. Leveraging Clinical Informatics in the Conduct of Clinical Trials. J Med Syst. 2015 Oct; 39(10): 112. PMID: 26276019, DOI: 10.1007/s10916-015-0317-0, ISSN: 1573-689X.

Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O'Brien J, O'Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS, . Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. Crit. Care Med. 2015 Oct; 43(10): 2076-84. PMID: 26110488, PMCID: PMC5673100, DOI: 10.1097/CCM.0000000000001157, ISSN: 1530-0293.

Stollings JL, Foss JJ, Ely EW, Ambrose AM, Rice TW, Girard TD, Wheeler AP. Pharmacist leadership in ICU quality improvement: coordinating spontaneous awakening and breathing trials. Ann Pharmacother [print-electronic]. 2015 Aug; 49(8): 883-91. PMID: 25907528, PII: 1060028015582050, DOI: 10.1177/1060028015582050, ISSN: 1542-6270.

Semler MW, Weavind L, Hooper MH, Rice TW, Gowda SS, Nadas A, Song Y, Martin JB, Bernard GR, Wheeler AP. An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial. Crit. Care Med. 2015 Aug; 43(8): 1595-602. PMID: 25867906, PMCID: PMC4506222, DOI: 10.1097/CCM.0000000000001020, ISSN: 1530-0293.

Fremont RD, Rice TW. Pros and cons of feeding the septic intensive care unit patient. Nutr Clin Pract [print-electronic]. 2015 Jun; 30(3): 344-50. PMID: 25855092, PII: 0884533615578457, DOI: 10.1177/0884533615578457, ISSN: 1941-2452.

Noto MJ, Rice TW, Wheeler AP. Chlorhexidine bathing and infections in critically ill patients--reply [letter]. JAMA. 2015 May 5/12/2015; 313(18): 1863-4. PMID: 25965240, PII: 2290631, DOI: 10.1001/jama.2015.3539, ISSN: 1538-3598.

Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, . Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit. Care Med. 2015 Mar; 43(3): 534-41. PMID: 25474535, PMCID: PMC4336619, DOI: 10.1097/CCM.0000000000000718, ISSN: 1530-0293.

Noto MJ, Domenico HJ, Byrne DW, Talbot T, Rice TW, Bernard GR, Wheeler AP. Chlorhexidine bathing and health care-associated infections: a randomized clinical trial. JAMA. 2015 Jan 1/27/2015; 313(4): 369-78. PMID: 25602496, PMCID: PMC4383133, PII: 2091544, DOI: 10.1001/jama.2014.18400, ISSN: 1538-3598.

McClave SA, Martindale RG, Rice TW, Heyland DK. Feeding the critically ill patient. Crit. Care Med. 2014 Dec; 42(12): 2600-10. PMID: 25251763, DOI: 10.1097/CCM.0000000000000654, ISSN: 1530-0293.

Rice TW. Immunonutrition in critical illness: limited benefit, potential harm [editorial]. JAMA. 2014 Aug 8/6/2014; 312(5): 490-1. PMID: 25096688, PII: 1892225, DOI: 10.1001/jama.2014.7699, ISSN: 1538-3598.

Keriwala RD, Rice TW. The ongoing challenge of evaluating rescue therapies in acute respiratory distress syndrome* [editorial]. Crit. Care Med. 2014 Jul; 42(7): 1727-8. PMID: 24933048, PMCID: PMC4118925, PII: 00003246-201407000-00019, DOI: 10.1097/CCM.0000000000000390, ISSN: 1530-0293.

Polito CC, Cribbs SK, Martin GS, O'Keeffe T, Herr D, Rice TW, Sevransky JE. Navigating the institutional review board approval process in a multicenter observational critical care study. Crit. Care Med. 2014 May; 42(5): 1105-9. PMID: 24368345, PMCID: PMC3989388, DOI: 10.1097/CCM.0000000000000133, ISSN: 1530-0293.

Desai SV, McClave SA, Rice TW. Nutrition in the ICU: an evidence-based approach. Chest. 2014 May; 145(5): 1148-57. PMID: 24798840, PII: S0012-3692(15)34610-9, DOI: 10.1378/chest.13-1158, ISSN: 1931-3543.

Fremont RD, Rice TW. How soon should we start interventional feeding in the ICU?. Curr. Opin. Gastroenterol. 2014 Mar; 30(2): 178-81. PMID: 24464030, PMCID: PMC4006101, DOI: 10.1097/MOG.0000000000000047, ISSN: 1531-7056.

Checkley W, Martin GS, Brown SM, Chang SY, Dabbagh O, Fremont RD, Girard TD, Rice TW, Howell MD, Johnson SB, O'Brien J, Park PK, Pastores SM, Patil NT, Pietropaoli AP, Putman M, Rotello L, Siner J, Sajid S, Murphy DJ, Sevransky JE, . Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study. Crit. Care Med. 2014 Feb; 42(2): 344-56. PMID: 24145833, PMCID: PMC4035482, DOI: 10.1097/CCM.0b013e3182a275d7, ISSN: 1530-0293.

Pollock JS, Hollenbeck RD, Wang L, Janz DR, Rice TW, McPherson JA. A history of smoking is associated with improved survival in patients treated with mild therapeutic hypothermia following cardiac arrest. Resuscitation [print-electronic]. 2014 Jan; 85(1): 99-103. PMID: 24036406, PMCID: PMC3905108, PII: S0300-9572(13)00714-4, DOI: 10.1016/j.resuscitation.2013.08.275, ISSN: 1873-1570.

Semler MW, Stover DG, Copland AP, Hong G, Johnson MJ, Kriss MS, Otepka H, Wang L, Christman BW, Rice TW. Flash mob research: a single-day, multicenter, resident-directed study of respiratory rate. Chest. 2013 Jun; 143(6): 1740-4. PMID: 23197319, PMCID: PMC3747725, PII: S0012-3692(13)60406-7, DOI: 10.1378/chest.12-1837, ISSN: 1931-3543.

Rice TW. ACP Journal Club. Hypoglycemia was associated with increased mortality in ICU patients regardless of glucose control strategy. Ann. Intern. Med. 2013 Jan 1/15/2013; 158(2): JC3. PMID: 23318337, PII: 1556387, DOI: 10.7326/0003-4819-158-2-201301150-02003, ISSN: 1539-3704.

Janz DR, Hollenbeck RD, Pollock JS, McPherson JA, Rice TW. Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit. Care Med. 2012 Dec; 40(12): 3135-9. PMID: 22971589, PMCID: PMC3502652, DOI: 10.1097/CCM.0b013e3182656976, ISSN: 1530-0293.

Bastarache JA, Ware LB, Girard TD, Wheeler AP, Rice TW. Markers of inflammation and coagulation may be modulated by enteral feeding strategy. JPEN J Parenter Enteral Nutr [print-electronic]. 2012 Nov; 36(6): 732-40. PMID: 22318965, PMCID: PMC3726194, PII: 0148607111433054, DOI: 10.1177/0148607111433054, ISSN: 0148-6071.

Rice TW, Rubinson L, Uyeki TM, Vaughn FL, John BB, Miller RR, Higgs E, Randolph AG, Smoot BE, Thompson BT, . Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit. Care Med. 2012 May; 40(5): 1487-98. PMID: 22511131, PMCID: PMC3653183, PII: 00003246-201205000-00013, DOI: 10.1097/CCM.0b013e3182416f23, ISSN: 1530-0293.

Rice TW, Morris S, Tortella BJ, Wheeler AP, Christensen MC. Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*. Crit. Care Med. 2012 Mar; 40(3): 778-86. PMID: 22036858, DOI: 10.1097/CCM.0b013e318236f168, ISSN: 1530-0293.

Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P, . Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA [print-electronic]. 2011 Oct 10/12/2011; 306(14): 1574-81. PMID: 21976613, PMCID: PMC3770348, PII: jama.2011.1435, DOI: 10.1001/jama.2011.1435, ISSN: 1538-3598.

Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J. Heart Lung Transplant [print-electronic]. 2011 Aug; 30(8): 904-11. PMID: 21493097, PMCID: PMC3129440, PII: S1053-2498(11)00831-X, DOI: 10.1016/j.healun.2011.02.016, ISSN: 1557-3117.

Luo YF, Robbins IM, Karatas M, Brixey AG, Rice TW, Light RW. Frequency of pleural effusions in patients with pulmonary arterial hypertension associated with connective tissue diseases. Chest [print-electronic]. 2011 Jul; 140(1): 42-7. PMID: 21212140, PII: chest.10-0227, DOI: 10.1378/chest.10-0227, ISSN: 1931-3543.

Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit. Care Med. 2011 May; 39(5): 967-74. PMID: 21242788, PMCID: PMC3102124, DOI: 10.1097/CCM.0b013e31820a905a, ISSN: 1530-0293.

Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW, . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care [print-electronic]. 2011; 15(2): R86. PMID: 21385351, PMCID: PMC3219344, PII: cc10084, DOI: 10.1186/cc10084, ISSN: 1466-609X.

Rice TW, Wheeler AP, Bernard GR, Vincent JL, Angus DC, Aikawa N, Demeyer I, Sainati S, Amlot N, Cao C, Ii M, Matsuda H, Mouri K, Cohen J. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit. Care Med. 2010 Aug; 38(8): 1685-94. PMID: 20562702, DOI: 10.1097/CCM.0b013e3181e7c5c9, ISSN: 1530-0293.

Hemnes AR, Newman AL, Rosenbaum B, Barrett TW, Zhou C, Rice TW, Newman JH. Bedside end-tidal CO2 tension as a screening tool to exclude pulmonary embolism. Eur. Respir. J [print-electronic]. 2010 Apr; 35(4): 735-41. PMID: 19717480, PII: 09031936.00084709, DOI: 10.1183/09031936.00084709, ISSN: 1399-3003.

Wheeler AP, Rice TW. Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing. Chest. 2010 Jan; 137(1): 185-94. PMID: 20051403, PII: 137/1/185, DOI: 10.1378/chest.08-2535, ISSN: 1931-3543.

Rice TW, Wheeler AP. Coagulopathy in critically ill patients: part 1: platelet disorders. Chest. 2009 Dec; 136(6): 1622-30. PMID: 19995764, PII: 136/6/1622, DOI: 10.1378/chest.08-2534, ISSN: 1931-3543.

Lancaster LH, Mason WR, Parnell JA, Rice TW, Loyd JE, Milstone AP, Collard HR, Malow BA. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest [print-electronic]. 2009 Sep; 136(3): 772-8. PMID: 19567497, PMCID: PMC2775994, PII: chest.08-2776, DOI: 10.1378/chest.08-2776, ISSN: 1931-3543.

Pandharipande PP, Shintani AK, Hagerman HE, St Jacques PJ, Rice TW, Sanders NW, Ware LB, Bernard GR, Ely EW. Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score. Crit. Care Med. 2009 Apr; 37(4): 1317-21. PMID: 19242333, PMCID: PMC3776410, DOI: 10.1097/CCM.0b013e31819cefa9, ISSN: 1530-0293.

Rice TW. How to do human-subjects research if you do not have an institutional review board. Respir Care. 2008 Oct; 53(10): 1362-7. PMID: 18812001, ISSN: 0020-1324.

Rice TW. The historical, ethical, and legal background of human-subjects research. Respir Care. 2008 Oct; 53(10): 1325-9. PMID: 18811995, ISSN: 0020-1324.

Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB, . Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest [print-electronic]. 2007 Aug; 132(2): 410-7. PMID: 17573487, PII: chest.07-0617, DOI: 10.1378/chest.07-0617, ISSN: 0012-3692.

Rice TW. Pleural effusions in superior vena cava syndrome: prevalence, characteristics, and proposed pathophysiology. Curr Opin Pulm Med. 2007 Jul; 13(4): 324-7. PMID: 17534180, PII: 00063198-200707000-00015, DOI: 10.1097/MCP.0b013e32812144aa, ISSN: 1070-5287.

Fremont RD, Rice TW. Splenosis: a review. South. Med. J. 2007 Jun; 100(6): 589-93. PMID: 17591312, DOI: 10.1097/SMJ.0b013e318038d1f8, ISSN: 0038-4348.

Rice TW, Bernard GR. Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design. Clin. Chest Med. 2006 Dec; 27(4): 733-54; abstract xi. PMID: 17085259, PII: S0272-5231(06)00074-8, DOI: 10.1016/j.ccm.2006.06.006, ISSN: 0272-5231.

Rice TW, Wheeler AP, Morris PE, Paz HL, Russell JA, Edens TR, Bernard GR. Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis. Crit. Care Med. 2006 Sep; 34(9): 2271-81. PMID: 16810105, DOI: 10.1097/01.CCM.0000230385.82679.34, ISSN: 0090-3493.

Rice TW, Rodriguez RM, Barnette R, Light RW. Prevalence and characteristics of pleural effusions in superior vena cava syndrome. Respirology. 2006 May; 11(3): 299-305. PMID: 16635088, PII: RES, DOI: 10.1111/j.1440-1843.2006.00841.x, ISSN: 1323-7799.

Rice TW, Rodriguez RM, Light RW. The superior vena cava syndrome: clinical characteristics and evolving etiology. Medicine (Baltimore). 2006 Jan; 85(1): 37-42. PMID: 16523051, PII: 00005792-200601000-00003, DOI: 10.1097/01.md.0000198474.99876.f0, ISSN: 0025-7974.

Rice TW. Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa. Vasc Health Risk Manag. 2006; 2(1): 3-18. PMID: 17319465, PMCID: PMC1993976, ISSN: 1176-6344.

Rice TW, Swope T, Bozeman S, Wheeler AP. Variation in enteral nutrition delivery in mechanically ventilated patients. Nutrition. 2005 Jul; 21(7-8): 786-92. PMID: 15975485, PII: S0899-9007(05)00133-4, DOI: 10.1016/j.nut.2004.11.014, ISSN: 0899-9007.

Rice TW, Bernard GR. Therapeutic intervention and targets for sepsis. Annu. Rev. Med. 2005; 56: 225-48. PMID: 15660511, DOI: 10.1146/annurev.med.56.082103.104356, ISSN: 0066-4219.

Rice TW, Bernard GR. Drotrecogin alfa (activated) for the treatment of severe sepsis and septic shock. Am. J. Med. Sci. 2004 Oct; 328(4): 205-14. PMID: 15486535, PII: 00000441-200410000-00003, ISSN: 0002-9629.

Rice TW, Milstone AP. Chylothorax as a result of chronic lymphocytic leukemia: case report and review of the literature. South. Med. J. 2004 Mar; 97(3): 291-4. PMID: 15043339, DOI: 10.1097/01.SMJ.0000072363.19239.FE, ISSN: 0038-4348.

Rice TW, Bernard GR. New additions to the intensive care armamentarium. Drugs Today. 2004 Feb; 40(2): 157-70. PMID: 15045037, PII: 799427, ISSN: 1699-3993.