Christine L. Konradi, Ph.D.

PMB 407933, MRB3, Suite 8160
465 21st Avenue South
Nashville, TN 37240

The Konradi Laboratory is interested in the influence of environment and experience on the molecular properties of the brain throughout life, and how these factors intersect with brain disorders. We aim to define the molecular events associated with learning, behavioral adaptation, and brain disorders. The approach we take is 'translational', spanning from neurons in culture to rodent models and the human brain. We use pharmacological paradigms such as exposure to drugs, behavioral models related to learning, anxiety and addiction, and pathological models of human diseases. Techniques applied in the lab include molecular biology and pharmacology techniques to characterize signal transduction pathways in neurons, and gene array technologies to examine altered gene expression patterns. These methodologial approaches are combined with studies of behavior. Our research is geared toward understanding (1) pathological conditions such as bipolar disorder, schizophrenia and Parkinson's disease, (2) the therapeutic action of drugs in the developing and the adult brain, and (3) drug abuse and its effect on the developing and adult brain.

dopamine, glutamate, mitochondria, bipolar disorder, schizophrenia, antipsychotic drugs, Parkinson's disease, prefrontal cortex, striatum, drug abuse, brain development, cellular respiration, mitochondrial function

Konradi C, Öngür D. Role of mitochondria and energy metabolism in schizophrenia and psychotic disorders. Schizophr. Res [print-electronic]. 2017 Sep; 187: 1-2. PMID: 28705531, PII: S0920-9964(17)30408-5, DOI: 10.1016/j.schres.2017.07.007, ISSN: 1573-2509.

Konradi C. Polymerase gamma in bipolar disorder: It's complicated [editorial]. Psychiatry Clin. Neurosci. 2017 Aug; 71(8): 507. PMID: 28776861, DOI: 10.1111/pcn.12531, ISSN: 1440-1819.

Korade Ž, Liu W, Warren EB, Armstrong K, Porter NA, Konradi C. Effect of psychotropic drug treatment on sterol metabolism. Schizophr. Res [print-electronic]. 2017 Feb 2/12/2017; PMID: 28202290, PII: S0920-9964(17)30072-5, DOI: 10.1016/j.schres.2017.02.001, ISSN: 1573-2509.

Warren EB, Aicher AE, Fessel JP, Konradi C. Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism. PLoS ONE. 2017; 12(12): e0190456. PMID: 29287112, PMCID: PMC5747477, PII: PONE-D-17-37612, DOI: 10.1371/journal.pone.0190456, ISSN: 1932-6203.

Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, Thiolat ML, Vescovi AL, Calabresi P, Bezard E, Morelli M, Konradi C, Pasqualetti M, Usiello A. Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques. PLoS ONE. 2017; 12(7): e0181677. PMID: 28742811, PMCID: PMC5526584, PII: PONE-D-17-19314, DOI: 10.1371/journal.pone.0181677, ISSN: 1932-6203.

Heckers S, Konradi C. GABAergic mechanisms of hippocampal hyperactivity in schizophrenia. Schizophr. Res [print-electronic]. 2015 Sep; 167(1-3): 4-11. PMID: 25449711, PMCID: PMC4402105, PII: S0920-9964(14)00533-7, DOI: 10.1016/j.schres.2014.09.041, ISSN: 1573-2509.

Heckers S, Konradi C. Substantia nigra hyperactivity in schizophrenia. Biol. Psychiatry. 2013 Jul 7/15/2013; 74(2): 82-3. PMID: 23809261, PII: S0006-3223(13)00387-9, DOI: 10.1016/j.biopsych.2013.04.017, ISSN: 1873-2402.

Konradi C, Sillivan SE, Clay HB. Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis. Neurobiol. Dis [print-electronic]. 2012 Jan; 45(1): 37-47. PMID: 21310238, PMCID: PMC3117935, PII: S0969-9961(11)00046-5, DOI: 10.1016/j.nbd.2011.01.025, ISSN: 1095-953X.

Sillivan SE, Konradi C. Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat. Neuroscience [print-electronic]. 2011 Dec 12/29/2011; 199: 501-14. PMID: 22015925, PMCID: PMC3253459, PII: S0306-4522(11)01178-X, DOI: 10.1016/j.neuroscience.2011.10.004, ISSN: 1873-7544.

Wang AY, Lohmann KM, Yang CK, Zimmerman EI, Pantazopoulos H, Herring N, Berretta S, Heckers S, Konradi C. Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region. Acta Neuropathol [print-electronic]. 2011 Nov; 122(5): 615-26. PMID: 21968533, PMCID: PMC4207060, DOI: 10.1007/s00401-011-0881-4, ISSN: 1432-0533.

Sillivan SE, Black YD, Naydenov AV, Vassoler FR, Hanlin RP, Konradi C. Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood. Biol. Psychiatry [print-electronic]. 2011 Sep 9/15/2011; 70(6): 583-92. PMID: 21571252, PMCID: PMC3159046, PII: S0006-3223(11)00335-0, DOI: 10.1016/j.biopsych.2011.03.035, ISSN: 1873-2402.

Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S. Hippocampal interneurons are abnormal in schizophrenia. Schizophr. Res [print-electronic]. 2011 Sep; 131(1-3): 165-73. PMID: 21745723, PMCID: PMC3159834, PII: S0920-9964(11)00312-4, DOI: 10.1016/j.schres.2011.06.007, ISSN: 1573-2509.

Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol. Psychiatry [print-electronic]. 2011 Sep 9/1/2011; 70(5): 425-33. PMID: 21531393, PMCID: PMC3150294, PII: S0006-3223(11)00261-7, DOI: 10.1016/j.biopsych.2011.03.017, ISSN: 1873-2402.

Ohlin KE, Francardo V, Lindgren HS, Sillivan SE, O'Sullivan SS, Luksik AS, Vassoler FM, Lees AJ, Konradi C, Cenci MA. Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia. Brain [print-electronic]. 2011 Aug; 134(Pt 8): 2339-57. PMID: 21771855, PMCID: PMC3155708, PII: awr165, DOI: 10.1093/brain/awr165, ISSN: 1460-2156.

Clay HB, Sillivan S, Konradi C. Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int. J. Dev. Neurosci [print-electronic]. 2011 May; 29(3): 311-24. PMID: 20833242, PMCID: PMC3010320, PII: S0736-5748(10)00380-1, DOI: 10.1016/j.ijdevneu.2010.08.007, ISSN: 1873-474X.

Konradi C, Zimmerman EI, Yang CK, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S. Hippocampal interneurons in bipolar disorder. Arch. Gen. Psychiatry [print-electronic]. 2011 Apr; 68(4): 340-50. PMID: 21135314, PMCID: PMC3197787, PII: archgenpsychiatry.2010.175, DOI: 10.1001/archgenpsychiatry.2010.175, ISSN: 1538-3636.

Herring NR, Konradi C. Myelin, copper, and the cuprizone model of schizophrenia. Front Biosci (Schol Ed). 2011; 3: 23-40. PMID: 21196354, PMCID: PMC3058516, PII: 129, ISSN: 1945-0524.

Naydenov AV, Vassoler F, Luksik AS, Kaczmarska J, Konradi C. Mitochondrial abnormalities in the putamen in Parkinson's disease dyskinesia. Acta Neuropathol [print-electronic]. 2010 Nov; 120(5): 623-31. PMID: 20740286, PMCID: PMC2955799, DOI: 10.1007/s00401-010-0740-8, ISSN: 1432-0533.

Cenci MA, Konradi C. Maladaptive striatal plasticity in L-DOPA-induced dyskinesia. Prog. Brain Res. 2010; 183: 209-33. PMID: 20696322, PMCID: PMC2930606, PII: S0079-6123(10)83011-0, DOI: 10.1016/S0079-6123(10)83011-0, ISSN: 1875-7855.

Heckers S, Konradi C. Hippocampal pathology in schizophrenia. Curr Top Behav Neurosci. 2010; 4: 529-53. PMID: 21312412, ISSN: 1866-3370.

Gregg JR, Herring NR, Naydenov AV, Hanlin RP, Konradi C. Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats. Schizophr. Res [print-electronic]. 2009 Sep; 113(2-3): 277-87. PMID: 19570651, PMCID: PMC2768476, PII: S0920-9964(09)00239-4, DOI: 10.1016/j.schres.2009.05.023, ISSN: 1573-2509.

Chartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Mol. Pharmacol [print-electronic]. 2009 Mar; 75(3): 704-12. PMID: 19106229, PMCID: PMC2684917, PII: mol.108.051417, DOI: 10.1124/mol.108.051417, ISSN: 1521-0111.

Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology [print-electronic]. 2008 Nov; 33(12): 2981-92. PMID: 18288092, PMCID: PMC2746694, PII: npp200815, DOI: 10.1038/npp.2008.15, ISSN: 1740-634X.

Levine JB, Leeder AD, Parekkadan B, Berdichevsky Y, Rauch SL, Smoller JW, Konradi C, Berthiaume F, Yarmush ML. Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats. Neuroscience [print-electronic]. 2008 Jan 1/24/2008; 151(2): 589-603. PMID: 18063315, PMCID: PMC3923447, PII: S0306-4522(07)01303-6, DOI: 10.1016/j.neuroscience.2007.10.014, ISSN: 0306-4522.

Westin JE, Vercammen L, Strome EM, Konradi C, Cenci MA. Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors. Biol. Psychiatry [print-electronic]. 2007 Oct 10/1/2007; 62(7): 800-10. PMID: 17662258, PMCID: PMC4205578, PII: S0006-3223(06)01551-4, DOI: 10.1016/j.biopsych.2006.11.032, ISSN: 0006-3223.

Naydenov AV, MacDonald ML, Ongur D, Konradi C. Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress. Arch. Gen. Psychiatry. 2007 May; 64(5): 555-64. PMID: 17485607, PII: 64/5/555, DOI: 10.1001/archpsyc.64.5.555, ISSN: 0003-990X.

Levine JB, Youngs RM, MacDonald ML, Chu M, Leeder AD, Berthiaume F, Konradi C. Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex. Neuroscience [print-electronic]. 2007 Mar 3/2/2007; 145(1): 42-55. PMID: 17239545, PII: S0306-4522(06)01644-7, DOI: 10.1016/j.neuroscience.2006.11.063, ISSN: 0306-4522.

Todtenkopf MS, Parsegian A, Naydenov A, Neve RL, Konradi C, Carlezon WA. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. J. Neurosci. 2006 Nov 11/8/2006; 26(45): 11665-9. PMID: 17093088, PMCID: PMC4205583, PII: 26/45/11665, DOI: 10.1523/JNEUROSCI.3070-06.2006, ISSN: 1529-2401.

Black YD, Maclaren FR, Naydenov AV, Carlezon WA, Baxter MG, Konradi C. Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J. Neurosci. 2006 Sep 9/20/2006; 26(38): 9656-65. PMID: 16988036, PMCID: PMC4203339, PII: 26/38/9656, DOI: 10.1523/JNEUROSCI.2391-06.2006, ISSN: 1529-2401.

MacDonald ML, Naydenov A, Chu M, Matzilevich D, Konradi C. Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder. Bipolar Disord. 2006 Jun; 8(3): 255-64. PMID: 16696827, PMCID: PMC4208624, PII: BDI302, DOI: 10.1111/j.1399-5618.2006.00302.x, ISSN: 1398-5647.

Youngs RM, Chu MS, Meloni EG, Naydenov A, Carlezon WA, Konradi C. Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences. J. Neurosci. 2006 May 5/31/2006; 26(22): 6031-9. PMID: 16738246, PMCID: PMC4205587, PII: 26/22/6031, DOI: 10.1523/JNEUROSCI.0580-06.2006, ISSN: 1529-2401.

Konradi C. Gene expression microarray studies in polygenic psychiatric disorders: applications and data analysis. Brain Res. Brain Res. Rev [print-electronic]. 2005 Dec 12/1/2005; 50(1): 142-55. PMID: 15964635, PII: S0165-0173(05)00078-0, DOI: 10.1016/j.brainresrev.2005.05.004.

MacDonald ML, Eaton ME, Dudman JT, Konradi C. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biol. Psychiatry. 2005 May 5/1/2005; 57(9): 1041-51. PMID: 15860345, PMCID: PMC2734482, PII: S0006-3223(05)00099-5, DOI: 10.1016/j.biopsych.2005.01.022, ISSN: 0006-3223.

Eaton ME, Macías W, Youngs RM, Rajadhyaksha A, Dudman JT, Konradi C. L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons. Brain Res. Mol. Brain Res. 2004 Nov 11/24/2004; 131(1-2): 65-72. PMID: 15530653, PMCID: PMC4203344, PII: S0169-328X(04)00401-2, DOI: 10.1016/j.molbrainres.2004.08.007, ISSN: 0169-328X.

Konradi C, Westin JE, Carta M, Eaton ME, Kuter K, Dekundy A, Lundblad M, Cenci MA. Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia. Neurobiol. Dis. 2004 Nov; 17(2): 219-36. PMID: 15474360, PMCID: PMC4208672, PII: S0969-9961(04)00159-7, DOI: 10.1016/j.nbd.2004.07.005, ISSN: 0969-9961.

Benes FM, Burke RE, Walsh J, Berretta S, Matzilevich D, Minns M, Konradi C. Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus. Mol. Psychiatry. 2004 Oct; 9(10): 932-45, 895. PMID: 15170462, PII: 4001524, DOI: 10.1038/sj.mp.4001524, ISSN: 1359-4184.

Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C, Akbarian S. Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J. Neurochem. 2004 Sep; 90(5): 1117-31. PMID: 15312167, PMCID: PMC4203323, PII: JNC2569, DOI: 10.1111/j.1471-4159.2004.02569.x, ISSN: 0022-3042.

Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch. Gen. Psychiatry. 2004 Mar; 61(3): 300-8. PMID: 14993118, PII: 61/3/300, DOI: 10.1001/archpsyc.61.3.300, ISSN: 0003-990X.

Carlezon WA, Konradi C. Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules. Neuropharmacology. 2004; 47 Suppl 1: 47-60. PMID: 15464125, PMCID: PMC4204484, PII: S0028390804001820, DOI: 10.1016/j.neuropharm.2004.06.021, ISSN: 0028-3908.

Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Ann. N. Y. Acad. Sci. 2003 Nov; 1003: 368-71. PMID: 14684463, ISSN: 0077-8923.

Dudman JT, Eaton ME, Rajadhyaksha A, Macías W, Taher M, Barczak A, Kameyama K, Huganir R, Konradi C. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J. Neurochem. 2003 Nov; 87(4): 922-34. PMID: 14622123, PMCID: PMC4203348, PII: 2067, ISSN: 0022-3042.

Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J. Neurochem. 2003 Oct; 87(1): 107-18. PMID: 12969258, PMCID: PMC4205588, PII: 1992, ISSN: 0022-3042.

Konradi C, Macías W, Dudman JT, Carlson RR. Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways. Brain Res. Mol. Brain Res. 2003 Jul 7/23/2003; 115(2): 157-61. PMID: 12877986, PMCID: PMC4205580, PII: S0169328X03002043, ISSN: 0169-328X.

Konradi C, Heckers S. Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol. Ther. 2003 Feb; 97(2): 153-79. PMID: 12559388, PMCID: PMC4203361, PII: S0163725802003285, ISSN: 0163-7258.

Konradi CL. Analysis of DNA-binding activity in neuronal tissue with the electrophoretic mobility-shift assay. Methods Mol. Med. 2003; 79: 315-27. PMID: 12506706, ISSN: 1543-1894.

Konradi CL. Quantification of protein in brain tissue by western immunoblot analysis. Methods Mol. Med. 2003; 79: 263-71. PMID: 12506702, ISSN: 1543-1894.

Konradi CL. Quantification of mRNA in neuronal tissue by northern analysis. Methods Mol. Med. 2003; 79: 161-79. PMID: 12506696, ISSN: 1543-1894.

Heckers S, Konradi C. Hippocampal neurons in schizophrenia. J Neural Transm (Vienna). 2002 May; 109(5-6): 891-905. PMID: 12111476, PMCID: PMC4205576, DOI: 10.1007/s007020200073, ISSN: 0300-9564.

Andersson M, Konradi C, Cenci MA. CAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum. J. Neurosci. 2001 Dec 12/15/2001; 21(24): 9930-43. PMID: 11739600, PMCID: PMC4204657, PII: 21/24/9930, ISSN: 1529-2401.

Konradi C, Heckers S. Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia. Biol. Psychiatry. 2001 Nov 11/15/2001; 50(10): 729-42. PMID: 11720691, PMCID: PMC4205586, PII: S0006-3223(01)01267-7, ISSN: 0006-3223.

Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J. Neurosci. 2001 Sep 9/15/2001; 21(18): 7397-403. PMID: 11549750, PMCID: PMC4205577, PII: 21/18/7397, ISSN: 1529-2401.

Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 2/2/2001; 890(2): 222-32. PMID: 11164788, PMCID: PMC4203340, PII: S0006-8993(00)03163-2, ISSN: 0006-8993.

Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. J. Neurosci. 2000 Jun 6/1/2000; 20(11): 4011-20. PMID: 10818136, PMCID: PMC4203343, PII: 20/11/4011, ISSN: 1529-2401.

Heckers S, Konradi C. Anatomic and molecular principles of psychopharmacology. A primer for psychiatrists. Child Adolesc Psychiatr Clin N Am. 2000 Jan; 9(1): 1-22. PMID: 10674188, ISSN: 1056-4993.

Berger UV, Luthi-Carter R, Passani LA, Elkabes S, Black I, Konradi C, Coyle JT. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. J. Comp. Neurol. 1999 Dec 12/6/1999; 415(1): 52-64. PMID: 10540357, PII: 10.1002/(SICI)1096-9861(19991206)415:1<52::AID-CNE4>3.0.CO;2-K, ISSN: 0021-9967.

Rajadhyaksha A, Barczak A, Macías W, Leveque JC, Lewis SE, Konradi C. L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J. Neurosci. 1999 Aug 8/1/1999; 19(15): 6348-59. PMID: 10414964, PMCID: PMC4204489, ISSN: 0270-6474.

Rajadhyaksha A, Leveque J, Macías W, Barczak A, Konradi C. Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Dev. Neurosci. 1998; 20(2-3): 204-15. PMID: 9691194, PMCID: PMC4205584, PII: dne20204, ISSN: 0378-5866.

Konradi C. The molecular basis of dopamine and glutamate interactions in the striatum. Adv. Pharmacol. 1998; 42: 729-33. PMID: 9328002, ISSN: 1054-3589.

Lewis SE, Konradi C. Analysis of DNA-Protein Interactions in the Nervous System Using the Electrophoretic Mobility Shift Assay. Methods. 1996 Dec; 10(3): 301-11. PMID: 8954842, PII: S1046202396901073, ISSN: 1095-9130.

Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainic acid induces apoptosis in neurons. Neuroscience. 1996 Dec; 75(4): 1047-55. PMID: 8938740, PII: 0306452296003260, ISSN: 0306-4522.

Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainate induces apoptosis in neurons. Neuroscience. 1996 Oct; 74(3): 675-83. PMID: 8884764, PII: 0306-4522(96)00141-8, ISSN: 0306-4522.

Konradi C, Leveque JC, Hyman SE. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J. Neurosci. 1996 Jul 7/1/1996; 16(13): 4231-9. PMID: 8753884, PMCID: PMC4203342, ISSN: 0270-6474.

Konradi C, Cole RL, Green D, Senatus P, Leveque JC, Pollack AE, Grossbard SJ, Hyman SE. Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. J. Neurochem. 1995 Sep; 65(3): 1007-15. PMID: 7643080, ISSN: 0022-3042.

Cole RL, Konradi C, Douglass J, Hyman SE. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron. 1995 Apr; 14(4): 813-23. PMID: 7718243, PMCID: PMC4207064, PII: 0896-6273(95)90225-2, ISSN: 0896-6273.

Konradi C, Heckers S. Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding protein. Neuroscience. 1995 Apr; 65(4): 1051-61. PMID: 7617161, PII: 0306-4522(94)00546-H, ISSN: 0306-4522.

Hyman SE, Cole RL, Konradi C, Kosofsky BE. Dopamine regulation of transcription factor-target interactions in rat striatum. Chem. Senses. 1995 Apr; 20(2): 257-60. PMID: 7583020, ISSN: 0379-864X.

Cole DG, Kobierski LA, Konradi C, Hyman SE. 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Proc. Natl. Acad. Sci. U.S.A. 1994 Sep 9/27/1994; 91(20): 9631-5. PMID: 7937819, PMCID: PMC44867, ISSN: 0027-8424.

Konradi C, Cole RL, Heckers S, Hyman SE. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J. Neurosci. 1994 Sep; 14(9): 5623-34. PMID: 8083758, ISSN: 0270-6474.

Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE. Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol. Endocrinol. 1994 Feb; 8(2): 240-8. PMID: 8170480, PMCID: PMC4205567, DOI: 10.1210/mend.8.2.8170480, ISSN: 0888-8809.

Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol. Endocrinol. 1994 Jan; 8(1): 116-25. PMID: 8152426, DOI: 10.1210/mend.8.1.8152426, ISSN: 0888-8809.

Hyman SE, Konradi C, Kobierski L, Cole R, Senatus P, Green D. Pharmacologic regulation of striatal proenkephalin gene expression via transcription factor CREB. Prog. Clin. Biol. Res. 1994; 390: 155-71. PMID: 7724644, ISSN: 0361-7742.

Konradi C, Kobierski LA, Nguyen TV, Heckers S, Hyman SE. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Proc. Natl. Acad. Sci. U.S.A. 1993 Aug 8/1/1993; 90(15): 7005-9. PMID: 8346209, PMCID: PMC47064, ISSN: 0027-8424.

Yan W, Boustany RM, Konradi C, Ozelius L, Lerner T, Trofatter JA, Julier C, Breakefield XO, Gusella JF, Haines JL. Localization of juvenile, but not late-infantile, neuronal ceroid lipofuscinosis on chromosome 16. Am. J. Hum. Genet. 1993 Jan; 52(1): 89-95. PMID: 8434611, PMCID: PMC1682098, ISSN: 0002-9297.

Girmen AS, Baenziger J, Hotamisligil GS, Konradi C, Shalish C, Sullivan JL, Breakefield XO. Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. J. Neurochem. 1992 Dec; 59(6): 2063-6. PMID: 1431894, ISSN: 0022-3042.

Konradi C, Kornhuber J, Sofic E, Heckers S, Riederer P, Beckmann H. Variations of monoamines and their metabolites in the human brain putamen. Brain Res. 1992 May 5/8/1992; 579(2): 285-90. PMID: 1628216, PII: 0006-8993(92)90062-E, ISSN: 0006-8993.

Konradi C, Ozelius L, Breakefield XO. Highly polymorphic (GT)n repeat sequence in intron II of the human MAOB gene. Genomics. 1992 Jan; 12(1): 176-7. PMID: 1733859, PII: 0888-7543(92)90426-S, ISSN: 0888-7543.

Konradi C, Ozelius L, Yan W, Gusella JF, Breakefield XO. Dinucleotide repeat polymorphism (D16S285) on human chromosome 16. Nucleic Acids Res. 1991 Oct 10/11/1991; 19(19): 5449. PMID: 1923837, PMCID: PMC328929, ISSN: 0305-1048.

Riederer P, Konradi C, Youdim MB. The role of MAO in dopaminergic transmission. Adv Neurol. 1990; 53: 149-53. PMID: 2173368, ISSN: 0091-3952.

Kornhuber J, Konradi C, Mack-Burkhardt F, Riederer P, Heinsen H, Beckmann H. Ontogenesis of monoamine oxidase-A and -B in the human brain frontal cortex. Brain Res. 1989 Oct 10/9/1989; 499(1): 81-6. PMID: 2804672, PII: 0006-8993(89)91136-0, ISSN: 0006-8993.

Riederer P, Konradi C, Hebenstreit G. [Neurochemical perspectives of the function of monoamine oxidases]. Psychiatr Prax. 1989 Aug; 16 Suppl 1: 7-10. PMID: 2685857, ISSN: 0303-4259.

Fritze J, Koronakis P, Konradi C, Riederer P. Isoelectric focusing of monoamine oxidase subtypes as identified by MAO inhibitors. Eur. J. Pharmacol. 1989 May 5/11/1989; 172(2): 147-54. PMID: 2767139, ISSN: 0014-2999.

Kornhuber J, Mack-Burkhardt F, Konradi C, Fritze J, Riederer P. Effect of antemortem and postmortem factors on [3H]MK-801 binding in the human brain: transient elevation during early childhood. Life Sci. 1989; 45(8): 745-9. PMID: 2674577, ISSN: 0024-3205.

Konradi C, Kornhuber J, Froelich L, Fritze J, Heinsen H, Beckmann H, Schulz E, Riederer P. Demonstration of monoamine oxidase-A and -B in the human brainstem by a histochemical technique. Neuroscience. 1989; 33(2): 383-400. PMID: 2622533, ISSN: 0306-4522.

Riederer P, Konradi C, Hebenstreit G, Youdim MB. Neurochemical perspectives to the function of monoamine oxidase. Acta Neurol. Scand., Suppl. 1989; 126: 41-5. PMID: 2618592, ISSN: 0065-1427.

Danielczyk W, Streifler M, Konradi C, Riederer P, Moll G. Platelet MAO-B activity and the psychopathology of Parkinson's disease, senile dementia and multi-infarct dementia. Acta Psychiatr Scand. 1988 Dec; 78(6): 730-6. PMID: 3223331, ISSN: 0001-690X.

Konradi C, Svoma E, Jellinger K, Riederer P, Denney R, Thibault J. Topographic immunocytochemical mapping of monoamine oxidase-A, monoamine oxidase-B and tyrosine hydroxylase in human post mortem brain stem. Neuroscience. 1988 Sep; 26(3): 791-802. PMID: 2904662, ISSN: 0306-4522.

Riederer P, Rausch WD, Schmidt B, Kruzik P, Konradi C, Sofic E, Danielczyk W, Fischer M, Ogris E. Biochemical fundamentals of Parkinson's disease. Mt. Sinai J. Med. 1988 Jan; 55(1): 21-8. PMID: 3279302, ISSN: 0027-2507.

Konradi C, Jellinger K, Riederer P, Nagatsu T. Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil. J. Neural Transm. 1987; 70(3-4): 369-76. PMID: 3681291.

Konradi C, Riederer P, Jellinger K, Denney R. Cellular action of MAO inhibitors. J. Neural Transm. Suppl. 1987; 25: 15-25. PMID: 3480938, ISSN: 0303-6995.

Riederer P, Konradi C, Schay V, Kienzl E, Birkmayer G, Danielczyk W, Sofic E, Youdim MB. Localization of MAO-A and MAO-B in human brain: a step in understanding the therapeutic action of L-deprenyl. Adv Neurol. 1987; 45: 111-8. PMID: 3030067, ISSN: 0091-3952.

Konradi C, Riederer P, Youdim MB. Hydrogen peroxide enhances the activity of monoamine oxidase type-B but not of type-A: a pilot study. J. Neural Transm. Suppl. 1986; 22: 61-73. PMID: 3097261, ISSN: 0303-6995.