Anna R. Hemnes, M.D.

Associate Professor

anna.r.hemnes@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.D., Johns Hopkins University, Baltimore, MarylandB.A., Columbia University, New York, New York
Office Address
T-1218 MCN
TN 2650
Publications
Elinoff JM, Agarwal R, Barnett CF, Benza RL, Cuttica MJ, Gharib AM, Gray MP, Hassoun PM, Hemnes AR, Humbert M, Kolb TM, Lahm T, Leopold JA, Mathai SC, McLaughlin VV, Preston IR, Rosenzweig EB, Shlobin OA, Steen VD, Zamanian RT, Solomon MA. Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg. A Joint National Institutes of Health Clinical Center and Pulmonary Hypertension Association Symposium Report. Am. J. Respir. Crit. Care Med. 2018 Jul 7/15/2018; 198(2): 166-74. PMID: 29425462, DOI: 10.1164/rccm.201710-2093PP, ISSN: 1535-4970.

O'Leary JM, Assad TR, Xu M, Farber-Eger E, Wells QS, Hemnes AR, Brittain EL. Lack of a Tricuspid Regurgitation Doppler Signal and Pulmonary Hypertension by Invasive Measurement. J Am Heart Assoc. 2018 Jun 6/30/2018; 7(13): PMID: 29960993, PII: JAHA.118.009362, DOI: 10.1161/JAHA.118.009362, ISSN: 2047-9980.

Whitaker ME, Nair V, Sinari S, Dherange PA, Natarajan B, Trutter L, Brittain EL, Hemnes AR, Austin ED, Patel K, Black SM, Garcia JGN, Yuan Md PhD JX, Vanderpool RR, Rischard F, Makino A, Bedrick EJ, Desai AA. Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension. Am. J. Med [print-electronic]. 2018 Jun; 131(6): 702.e7-702.e13. PMID: 29421689, PMCID: PMC5963998, PII: S0002-9343(18)30091-3, DOI: 10.1016/j.amjmed.2017.12.046, ISSN: 1555-7162.

Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Eur. Respir. J [electronic-print]. 2018 Jun; 51(6): PMID: 29903860, PII: 13993003.02638-2017, DOI: 10.1183/13993003.02638-2017, ISSN: 1399-3003.

Yang BQ, Assad TR, O'Leary JM, Xu M, Halliday SJ, D'Amico RW, Farber-Eger EH, Wells QS, Hemnes AR, Brittain EL. Racial differences in patients referred for right heart catheterization and risk of pulmonary hypertension. Pulm Circ [print-electronic]. 2018 Apr; 8(2): 2045894018764273. PMID: 29480090, PMCID: PMC5858628, DOI: 10.1177/2045894018764273, ISSN: 2045-8932.

Hemnes AR, Brittain EL. Autonomic Nervous System in Pulmonary Arterial Hypertension: Time to Rest and Digest [editorial]. Circulation. 2018 Feb 2/27/2018; 137(9): 925-7. PMID: 29483171, PMCID: PMC5830155, PII: CIRCULATIONAHA.117.032355, DOI: 10.1161/CIRCULATIONAHA.117.032355, ISSN: 1524-4539.

Meoli DF, Su YR, Brittain EL, Robbins IM, Hemnes AR, Monahan K. The transpulmonary ratio of endothelin 1 is elevated in patients with preserved left ventricular ejection fraction and combined pre- and post-capillary pulmonary hypertension. Pulm Circ [print-electronic]. 2018 Jan; 8(1): 2045893217745019. PMID: 29251543, PMCID: PMC5764145, DOI: 10.1177/2045893217745019, ISSN: 2045-8932.

Hemnes AR. Using Omics to Understand and Treat Pulmonary Vascular Disease. Front Med (Lausanne). 2018; 5: 157. PMID: 29881726, PMCID: PMC5976753, DOI: 10.3389/fmed.2018.00157, ISSN: 2296-858X.

Hemnes AR, Humbert M. Pathobiology of pulmonary arterial hypertension: understanding the roads less travelled. Eur Respir Rev [electronic-print]. 2017 Dec 12/31/2017; 26(146): PMID: 29263173, PII: 26/146/170093, DOI: 10.1183/16000617.0093-2017, ISSN: 1600-0617.

Assad TR, Maron BA, Robbins IM, Xu M, Huang S, Harrell FE, Farber-Eger EH, Wells QS, Choudhary G, Hemnes AR, Brittain EL. Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension. JAMA Cardiol. 2017 Dec 12/1/2017; 2(12): 1361-8. PMID: 29071338, PMCID: PMC5814998, PII: 2659488, DOI: 10.1001/jamacardio.2017.3882, ISSN: 2380-6591.

Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA, . PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ. Res. 2017 Oct 10/27/2017; 121(10): 1136-9. PMID: 29074534, PMCID: PMC5685561, PII: CIRCRESAHA.117.311737, DOI: 10.1161/CIRCRESAHA.117.311737, ISSN: 1524-4571.

Welch CE, Hemnes AR. Reply: Tidal Carbon Dioxide as a Prognostic Feature in Inoperable Chronic Thromboembolic Pulmonary Hypertension. Ann Am Thorac Soc. 2017 Oct; 14(10): 1604-5. PMID: 28806530, DOI: 10.1513/AnnalsATS.201707-621LE, ISSN: 2325-6621.

Chen X, Austin ED, Talati M, Fessel JP, Farber-Eger EH, Brittain EL, Hemnes AR, Loyd JE, West J. Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects. Eur. Respir. J [electronic-print]. 2017 Aug; 50(2): PMID: 28775043, PII: 50/2/1602337, DOI: 10.1183/13993003.02337-2016, ISSN: 1399-3003.

Hemnes AR. Rebuttal From Dr Hemnes [editorial]. Chest [print-electronic]. 2017 Jul; 152(1): 20-1. PMID: 28065564, PII: S0012-3692(16)62630-2, DOI: 10.1016/j.chest.2016.12.010, ISSN: 1931-3543.

Hemnes AR. COUNTERPOINT: Should Wireless Pulmonary Artery Hemodynamic Monitoring Be Used to Monitor Patients With Pulmonary Hypertension? No [editorial]. Chest [print-electronic]. 2017 Jul; 152(1): 16-8. PMID: 28065561, PII: S0012-3692(16)62629-6, DOI: 10.1016/j.chest.2016.12.009, ISSN: 1931-3543.

O'Leary JM, Assad TR, Xu M, Birdwell KA, Farber-Eger E, Wells QS, Hemnes AR, Brittain EL. Pulmonary hypertension in patients with chronic kidney disease: invasive hemodynamic etiology and outcomes. Pulm Circ [print-electronic]. 2017 Jul; 7(3): 674-83. PMID: 28660793, PMCID: PMC5841902, DOI: 10.1177/2045893217716108, ISSN: 2045-8932.

Trammell AW, Talati M, Blackwell TR, Fortune NL, Niswender KD, Fessel JP, Newman JH, West JD, Hemnes AR. Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension. Pulm Circ [print-electronic]. 2017 Jul; 7(3): 624-34. PMID: 28704134, PMCID: PMC5841889, DOI: 10.1086/689908, ISSN: 2045-8932.

Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L. Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am. J. Respir. Crit. Care Med. 2017 Jun 6/15/2017; 195(12): 1661-70. PMID: 28430547, PMCID: PMC5476915, DOI: 10.1164/rccm.201701-0150WS.

Welch CE, Brittain EL, Newman AL, Robbins IM, Pugh ME, Newman JH, Hemnes AR. End-Tidal Carbon Dioxide as a Prognostic Feature in Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2017 Jun; 14(6): 896-902. PMID: 28345964, DOI: 10.1513/AnnalsATS.201612-951OC, ISSN: 2325-6621.

Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J. Clin. Invest [print-electronic]. 2017 Jun 6/1/2017; 127(6): 2262-76. PMID: 28463231, PMCID: PMC5451236, PII: 88629, DOI: 10.1172/JCI88629, ISSN: 1558-8238.

Halliday SJ, Hemnes AR. Identifying "super responders" in pulmonary arterial hypertension. Pulm Circ [print-electronic]. 2017 Apr; 7(2): 300-11. PMID: 28597766, PMCID: PMC5467924, DOI: 10.1177/2045893217697708, ISSN: 2045-8932.

Brittain EL, Nwabuo C, Xu M, Gupta DK, Hemnes AR, Moreira HT, De Vasconcellos HD, Terry JG, Carr JJ, Lima JA. Echocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study: Associations With Race and Metabolic Dysregulation. J Am Heart Assoc. 2017 Mar 3/30/2017; 6(4): PMID: 28360228, PMCID: PMC5533013, PII: JAHA.116.005111, DOI: 10.1161/JAHA.116.005111, ISSN: 2047-9980.

Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ, Hemnes AR, West J, Fessel JP. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulm Circ. 2017 Mar; 7(1): 186-99. PMID: 28680578, PMCID: PMC5448547, PII: 10.1086_690236, DOI: 10.1086/690236, ISSN: 2045-8932.

Assad TR, Hemnes AR, Larkin EK, Glazer AM, Xu M, Wells QS, Farber-Eger EH, Sheng Q, Shyr Y, Harrell FE, Newman JH, Brittain EL. Clinical and Biological Insights Into Combined Post- and Pre-Capillary Pulmonary Hypertension. J. Am. Coll. Cardiol. 2016 Dec 12/13/2016; 68(23): 2525-36. PMID: 27931609, PMCID: PMC5157701, PII: S0735-1097(16)36493-2, DOI: 10.1016/j.jacc.2016.09.942, ISSN: 1558-3597.

Gaskill C, Marriott S, Pratap S, Menon S, Hedges LK, Fessel JP, Kropski JA, Ames D, Wheeler L, Loyd JE, Hemnes AR, Roop DR, Klemm DJ, Austin ED, Majka SM. Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease. Pulm Circ. 2016 Dec; 6(4): 483-97. PMID: 28090290, PMCID: PMC5210051, PII: PC2013372, DOI: 10.1086/688314, ISSN: 2045-8932.

Assad TR, Brittain EL, Wells QS, Farber-Eger EH, Halliday SJ, Doss LN, Xu M, Wang L, Harrell FE, Yu C, Robbins IM, Newman JH, Hemnes AR. Hemodynamic evidence of vascular remodeling in combined post- and precapillary pulmonary hypertension. Pulm Circ. 2016 Sep; 6(3): 313-21. PMID: 27683608, PMCID: PMC5019084, PII: PC2013344, DOI: 10.1086/688516, ISSN: 2045-8932.

Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2016 Aug 8/15/2016; 194(4): 464-75. PMID: 26926454, DOI: 10.1164/rccm.201508-1678OC, ISSN: 1535-4970.

Naeije R, Hemnes AR. The difficult diagnosis of pulmonary vascular disease in heart failure [editorial]. Eur. Respir. J. 2016 Aug; 48(2): 308-10. PMID: 27478187, PII: 48/2/308, DOI: 10.1183/13993003.00789-2016, ISSN: 1399-3003.

Austin ED, West J, Loyd JE, Hemnes AR. Molecular Medicine of Pulmonary Arterial Hypertension: From Population Genetics to Precision Medicine and Gene Editing. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Jul 7/11/2016; PMID: 27398627, DOI: 10.1164/rccm.201605-0905PP, ISSN: 1535-4970.

Kocurek EG, Hemnes AR. Women's Health and Lung Development and Disease. Obstet. Gynecol. Clin. North Am. 2016 Jun; 43(2): 307-23. PMID: 27212094, PII: S0889-8545(16)00016-4, DOI: 10.1016/j.ogc.2016.01.003, ISSN: 1558-0474.

West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. Pulm Circ. 2016 Jun; 6(2): 211-23. PMID: 27252848, PMCID: PMC4869926, PII: PC2013314, DOI: 10.1086/686140, ISSN: 2045-8932.

Matthews DT, Le CN, Robbins IM, Petracek MR, Pugh ME, Brittain EL, Hemnes AR. Severity of pulmonary hypertension and obesity are not associated with worse functional outcomes after pulmonary thromboendarterectomy. Pulm Circ. 2016 Jun; 6(2): 174-80. PMID: 27252843, PMCID: PMC4869921, PII: PC2013298, DOI: 10.1086/685736, ISSN: 2045-8932.

Matthews DT, Hemnes AR. Current concepts in the pathogenesis of chronic thromboembolic pulmonary hypertension. Pulm Circ. 2016 Jun; 6(2): 145-54. PMID: 27252839, PMCID: PMC4869917, PII: PC2013306, DOI: 10.1086/686011, ISSN: 2045-8932.

Robbins IM, Pugh ME, Hemnes AR. Update on chronic thromboembolic pulmonary hypertension. Trends Cardiovasc. Med [print-electronic]. 2016 May 5/25/2016; PMID: 27345156, PII: S1050-1738(16)30054-8, DOI: 10.1016/j.tcm.2016.05.010, ISSN: 1873-2615.

Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 May 5/17/2016; 133(20): 1936-44. PMID: 27006481, PMCID: PMC4870107, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.

Mar PL, Nwazue V, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Loyd JE, Hemnes AR, Robbins IM, Robertson D, Raj SR, Austin ED. Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction. Chest [print-electronic]. 2016 May; 149(5): 1252-60. PMID: 26836906, PMCID: PMC4944774, PII: S0012-3692(15)00181-6, DOI: 10.1016/j.chest.2015.11.015, ISSN: 1931-3543.

Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Apr 4/14/2016; PMID: 27077479, DOI: 10.1164/rccm.201507-1444OC, ISSN: 1535-4970.

Hay BR, Pugh ME, Robbins IM, Hemnes AR. Parenteral Prostanoid Use at a Tertiary Referral Center: A Retrospective Cohort Study. Chest [print-electronic]. 2016 Mar; 149(3): 660-6. PMID: 26378379, PMCID: PMC4944766, PII: S0012-3692(15)00020-3, DOI: 10.1378/chest.15-1051, ISSN: 1931-3543.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PMCID: PMC4838140, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.

Lewis GD, Ngo D, Hemnes AR, Farrell L, Domos C, Pappagianopoulos PP, Dhakal BP, Souza A, Shi X, Pugh ME, Beloiartsev A, Sinha S, Clish CB, Gerszten RE. Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension. J. Am. Coll. Cardiol. 2016 Jan 1/19/2016; 67(2): 174-89. PMID: 26791065, PMCID: PMC4962613, PII: S0735-1097(15)07364-7, DOI: 10.1016/j.jacc.2015.10.072, ISSN: 1558-3597.

Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED. Estrogen Metabolite 16a-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism. Circulation [print-electronic]. 2016 Jan 1/5/2016; 133(1): 82-97. PMID: 26487756, PMCID: PMC4698046, PII: CIRCULATIONAHA.115.016133, DOI: 10.1161/CIRCULATIONAHA.115.016133, ISSN: 1524-4539.

Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD. Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Pulm Circ. 2015 Dec; 5(4): 681-90. PMID: 26697175, PMCID: PMC4671742, PII: PC2013257, DOI: 10.1086/683811, ISSN: 2045-8932.

Su YR, Chiusa M, Brittain E, Hemnes AR, Absi TS, Lim CC, Di Salvo TG. Right ventricular protein expression profile in end-stage heart failure. Pulm Circ. 2015 Sep; 5(3): 481-97. PMID: 26401249, PMCID: PMC4556499, PII: PC2013184, DOI: 10.1086/682219, ISSN: 2045-8932.

Hemnes AR, Kiely DG, Cockrill BA, Safdar Z, Wilson VJ, Al Hazmi M, Preston IR, MacLean MR, Lahm T. Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute. Pulm Circ. 2015 Sep; 5(3): 435-65. PMID: 26401246, PMCID: PMC4556496, PII: PC2013197, DOI: 10.1086/682230, ISSN: 2045-8932.

Robbins IM, Johnson J, Petracek M, Lambright E, Bream P, Merantz S, Pugh ME, Hemnes AR. Translocation of Microspheres into the Pulmonary Artery after Bronchial Artery Injection. Am. J. Respir. Crit. Care Med. 2015 Jun 6/15/2015; 191(12): e28-9. PMID: 26075434, DOI: 10.1164/rccm.201412-2325IM, ISSN: 1535-4970.

Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers. Pulm Circ. 2015 Jun; 5(2): 356-63. PMID: 26064462, PMCID: PMC4449248, PII: PC2013183, DOI: 10.1086/681264, ISSN: 2045-8932.

Newman JH, Brittain EL, Robbins IM, Hemnes AR. Effect of acute arteriolar vasodilation on capacitance and resistance in pulmonary arterial hypertension. Chest. 2015 Apr; 147(4): 1080-5. PMID: 25340330, PMCID: PMC4388116, PII: S0012-3692(15)38957-1, DOI: 10.1378/chest.14-1461, ISSN: 1931-3543.

Halliday SJ, Hemnes AR, Robbins IM, Pugh ME, Zhao DX, Piana RN, Fong PP, Brittain EL. Prognostic value of acute vasodilator response in pulmonary arterial hypertension: beyond the "classic" responders. J. Heart Lung Transplant [print-electronic]. 2015 Mar; 34(3): 312-8. PMID: 25577565, PMCID: PMC4380573, PII: S1053-2498(14)01424-7, DOI: 10.1016/j.healun.2014.10.003, ISSN: 1557-3117.

Assad TR, Hemnes AR. Metabolic Dysfunction in Pulmonary Arterial Hypertension. Curr. Hypertens. Rep. 2015 Mar; 17(3): 20. PMID: 25754317, PMCID: PMC4840894, DOI: 10.1007/s11906-014-0524-y, ISSN: 1534-3111.

Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation [print-electronic]. 2015 Jan 1/27/2015; 131(4): 401-9; discussion 409. PMID: 25361553, PMCID: PMC4308423, PII: CIRCULATIONAHA.114.013317, DOI: 10.1161/CIRCULATIONAHA.114.013317, ISSN: 1524-4539.

Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec; 4(4): 679-84. PMID: 25610603, PMCID: PMC4278627, PII: PC2013117, DOI: 10.1086/678514, ISSN: 2045-8932.

Brittain EL, Janz DR, Austin ED, Bastarache JA, Wheeler LA, Ware LB, Hemnes AR. Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension. Chest. 2014 Dec; 146(6): 1478-85. PMID: 24945582, PMCID: PMC4251612, PII: S0012-3692(15)51517-1, DOI: 10.1378/chest.14-0809, ISSN: 1931-3543.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): C415-30. PMID: 24871858, PMCID: PMC4154073, PII: ajpcell.00057.2014, DOI: 10.1152/ajpcell.00057.2014, ISSN: 1522-1563.

Hemnes AR. Pulmonary arterial hypertension treatment guidelines: new answers and even more questions [editorial]. Chest. 2014 Aug; 146(2): 239-41. PMID: 25091747, PMCID: PMC4137589, PII: S0012-3692(15)48805-1, DOI: 10.1378/chest.14-1440, ISSN: 1931-3543.

Pugh ME, Sivarajan L, Wang L, Robbins IM, Newman JH, Hemnes AR. Causes of pulmonary hypertension in the elderly. Chest. 2014 Jul; 146(1): 159-66. PMID: 24480915, PMCID: PMC4077408, PII: S0012-3692(15)48760-4, DOI: 10.1378/chest.13-1900, ISSN: 1931-3543.

Benson L, Brittain EL, Pugh ME, Austin ED, Fox K, Wheeler L, Robbins IM, Hemnes AR. Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension. Pulm Circ. 2014 Jun; 4(2): 311-8. PMID: 25006450, PMCID: PMC4070784, PII: PC2013057, DOI: 10.1086/675994, ISSN: 2045-8932.

Zhao M, Austin ED, Hemnes AR, Loyd JE, Zhao Z. An evidence-based knowledgebase of pulmonary arterial hypertension to identify genes and pathways relevant to pathogenesis. Mol Biosyst [print-electronic]. 2014 Apr; 10(4): 732-40. PMID: 24448676, PMCID: PMC3950334, DOI: 10.1039/c3mb70496c, ISSN: 1742-2051.

Brittain EL, Hemnes AR. One generation's "junk" is another's treasure: the emerging role of microRNAs as therapeutic targets [editorial]. J. Heart Lung Transplant [print-electronic]. 2014 Mar; 33(3): 233-4. PMID: 24462555, PMCID: PMC4837650, PII: S1053-2498(13)01574-X, DOI: 10.1016/j.healun.2013.12.020, ISSN: 1557-3117.

Best DH, Sumner KL, Austin ED, Chung WK, Brown LM, Borczuk AC, Rosenzweig EB, Bayrak-Toydemir P, Mao R, Cahill BC, Tazelaar HD, Leslie KO, Hemnes AR, Robbins IM, Elliott CG. EIF2AK4 mutations in pulmonary capillary hemangiomatosis. Chest. 2014 Feb; 145(2): 231-6. PMID: 24135949, PMCID: PMC3921094, PII: S0012-3692(15)34162-3, DOI: 10.1378/chest.13-2366, ISSN: 1931-3543.

Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana RN, Fong PP, Newman JH. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail [print-electronic]. 2014 Jan; 7(1): 116-22. PMID: 24297689, PMCID: PMC3934572, PII: CIRCHEARTFAILURE.113.000468, DOI: 10.1161/CIRCHEARTFAILURE.113.000468, ISSN: 1941-3297.

Pugh ME, Hemnes AR, Robbins IM. Combination therapy in pulmonary arterial hypertension. Clin. Chest Med [print-electronic]. 2013 Dec; 34(4): 841-55. PMID: 24267308, PII: S0272-5231(13)00107-X, DOI: 10.1016/j.ccm.2013.08.007, ISSN: 1557-8216.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Austin ED, Hemnes AR. Prostanoids but not oral therapies improve right ventricular function in pulmonary arterial hypertension. JACC Heart Fail. 2013 Aug; 1(4): 300-7. PMID: 24015376, PMCID: PMC3763862, PII: S2213-1779(13)00189-3, DOI: 10.1016/j.jchf.2013.05.004, ISSN: 2213-1787.

West J, Niswender KD, Johnson JA, Pugh ME, Gleaves L, Fessel JP, Hemnes AR. A potential role for insulin resistance in experimental pulmonary hypertension. Eur. Respir. J [print-electronic]. 2013 Apr; 41(4): 861-71. PMID: 22936709, PMCID: PMC3746982, PII: 09031936.00030312, DOI: 10.1183/09031936.00030312, ISSN: 1399-3003.

Monahan K, Scott TA, Su YR, Lenneman CG, Zhao DX, Robbins IM, Hemnes AR. Reproducibility of intracardiac and transpulmonary biomarkers in the evaluation of pulmonary hypertension. Pulm Circ. 2013 Apr; 3(2): 345-9. PMID: 24015334, PMCID: PMC3757828, PII: PC-3-345, DOI: 10.4103/2045-8932.114762, ISSN: 2045-8932.

Brittain EL, Pugh ME, Wang L, Newman AL, Robbins IM, Newman JH, Hemnes AR. Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension. PLoS ONE. 2013; 8(10): e76461. PMID: 24124561, PMCID: PMC3790694, PII: PONE-D-13-27489, DOI: 10.1371/journal.pone.0076461, ISSN: 1932-6203.

Pugh ME, Buchowski MS, Robbins IM, Newman JH, Hemnes AR. Physical activity limitation as measured by accelerometry in pulmonary arterial hypertension. Chest. 2012 Dec; 142(6): 1391-8. PMID: 22576635, PMCID: PMC3515022, PII: chest.12-0150, DOI: 10.1378/chest.12-0150, ISSN: 1931-3543.

Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/1/2012; 186(9): 892-6. PMID: 22923661, PMCID: PMC3530218, PII: rccm.201205-0886OC, DOI: 10.1164/rccm.201205-0886OC, ISSN: 1535-4970.

Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH. Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ. 2012 Jul; 2(3): 352-8. PMID: 23130103, PMCID: PMC3487303, PII: PC-2-352, DOI: 10.4103/2045-8932.101647, ISSN: 2045-8940.

Brittain EL, Hemnes AR, Keebler M, Lawson M, Byrd BF, Disalvo T. Right ventricular plasticity and functional imaging. Pulm Circ. 2012 Jul; 2(3): 309-26. PMID: 23130100, PMCID: PMC3487300, PII: PC-2-309, DOI: 10.4103/2045-8932.101407, ISSN: 2045-8940.

Fessel JP, Hamid R, Wittmann BM, Robinson LJ, Blackwell T, Tada Y, Tanabe N, Tatsumi K, Hemnes AR, West JD. Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ. 2012 Apr; 2(2): 201-13. PMID: 22837861, PMCID: PMC3401874, PII: PC-2-201, DOI: 10.4103/2045-8932.97606, ISSN: 2045-8940.

Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): L474-84. PMID: 22180660, PMCID: PMC3311512, PII: ajplung.00202.2011, DOI: 10.1152/ajplung.00202.2011, ISSN: 1522-1504.

Austin ED, Hamid R, Hemnes AR, Loyd JE, Blackwell T, Yu C, Phillips Iii JA, Gaddipati R, Gladson S, Gu E, West J, Lane KB. BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ. 2012; 3(1): 6. PMID: 22348410, PMCID: PMC3310853, PII: 2042-6410-3-6, DOI: 10.1186/2042-6410-3-6, ISSN: 2042-6410.

Hemnes AR, Pugh ME, Newman AL, Robbins IM, Tolle J, Austin ED, Newman JH. End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment. Chest [print-electronic]. 2011 Nov; 140(5): 1267-73. PMID: 21622547, PII: chest.11-0155, DOI: 10.1378/chest.11-0155, ISSN: 1931-3543.

Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J. Heart Lung Transplant [print-electronic]. 2011 Aug; 30(8): 904-11. PMID: 21493097, PMCID: PMC3129440, PII: S1053-2498(11)00831-X, DOI: 10.1016/j.healun.2011.02.016, ISSN: 1557-3117.

Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul; 1(3): 389-98. PMID: 22140629, PMCID: PMC3224431, PII: PC-1-389, DOI: 10.4103/2045-8932.87308, ISSN: 2045-8940.

Robbins IM, Hemnes AR, Gibbs JS, Christman BW, Howard L, Meehan S, Cabrita I, Gonzalez R, Oyler T, Zhao L, Du RH, Mendes LA, Wilkins MR. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Exp. Lung Res [print-electronic]. 2011 Feb; 37(1): 26-34. PMID: 21077779, DOI: 10.3109/01902148.2010.512972, ISSN: 1521-0499.

Lane KL, Talati M, Austin E, Hemnes AR, Johnson JA, Fessel JP, Blackwell T, Mernaugh RL, Robinson L, Fike C, Roberts LJ, West J. Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ. 2011; 1(1): 72-83. PMID: 21904662, PMCID: PMC3167174, DOI: 10.4103/2045-8932.78107, ISSN: 2045-8932.

Johnson JA, West J, Maynard KB, Hemnes AR. ACE2 improves right ventricular function in a pressure overload model. PLoS ONE [print-electronic]. 2011; 6(6): e20828. PMID: 21695173, PMCID: PMC3112229, PII: PONE-D-11-05233, DOI: 10.1371/journal.pone.0020828, ISSN: 1932-6203.

Pugh ME, Hemnes AR. Pulmonary hypertension in women. Expert Rev Cardiovasc Ther. 2010 Nov; 8(11): 1549-58. PMID: 21090930, PMCID: PMC3077035, DOI: 10.1586/erc.10.137, ISSN: 1744-8344.

Pugh ME, Hemnes AR. Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man. Int J Clin Pract Suppl. 2010 Nov; (168): 5-13. PMID: 20939841, PMCID: PMC2965027, DOI: 10.1111/j.1742-1241.2010.02523.x, ISSN: 1368-504X.

Hemnes AR, Newman AL, Rosenbaum B, Barrett TW, Zhou C, Rice TW, Newman JH. Bedside end-tidal CO2 tension as a screening tool to exclude pulmonary embolism. Eur. Respir. J [print-electronic]. 2010 Apr; 35(4): 735-41. PMID: 19717480, PII: 09031936.00084709, DOI: 10.1183/09031936.00084709, ISSN: 1399-3003.

Pugh ME, Hemnes AR. Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease. Womens Health (Lond Engl). 2010 Mar; 6(2): 285-96. PMID: 20187732, PMCID: PMC2853883, DOI: 10.2217/whe.09.88, ISSN: 1745-5065.

Hemnes AR, Doyle TP, Janssen D, Robbins IM. Congenital pulmonary artery stenoses masquerading as chronic thromboembolic disease. J. Heart Lung Transplant. 2009 Oct; 28(10): 1110-1. PMID: 19782296, PMCID: PMC2757639, PII: S1053-2498(09)00485-9, DOI: 10.1016/j.healun.2009.06.014, ISSN: 1557-3117.

Hemnes AR, Forfia PR, Champion HC. Assessment of pulmonary vasculature and right heart by invasive haemodynamics and echocardiography. Int J Clin Pract Suppl. 2009 Sep; (162): 4-19. PMID: 19624796, PII: IJCP2110, DOI: 10.1111/j.1742-1241.2009.02110.x, ISSN: 1368-504X.

Robbins IM, Newman JH, Johnson RF, Hemnes AR, Fremont RD, Piana RN, Zhao DX, Byrne DW. Association of the metabolic syndrome with pulmonary venous hypertension. Chest [print-electronic]. 2009 Jul; 136(1): 31-6. PMID: 19188551, PMCID: PMC2716716, PII: chest.08-2008, DOI: 10.1378/chest.08-2008, ISSN: 1931-3543.

Hemnes AR, Bertram A, Sisson SD. Impact of medical residency on knowledge of asthma. J Asthma. 2009 Feb; 46(1): 36-40. PMID: 19191135, PII: 908458193, DOI: 10.1080/02770900802460571, ISSN: 1532-4303.

Hemnes AR, Robbins IM. Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation. Liver Transpl. 2009 Jan; 15(1): 15-9. PMID: 19109843, PMCID: PMC3804427, DOI: 10.1002/lt.21479, ISSN: 1527-6473.

Hemnes AR, Champion HC. Right heart function and haemodynamics in pulmonary hypertension. Int J Clin Pract Suppl. 2008 Jul; (160): 11-9. PMID: 18638171, PII: IJCP1812, DOI: 10.1111/j.1742-1241.2008.01812.x, ISSN: 1368-504X.

Hemnes AR, Gaine SP, Wiener CM. Poor outcomes associated with drainage of pericardial effusions in patients with pulmonary arterial hypertension. South. Med. J. 2008 May; 101(5): 490-4. PMID: 18414173, DOI: 10.1097/SMJ.0b013e31816c0169, ISSN: 1541-8243.