Adam C. Seegmiller, M.D., Ph.D.

Associate Professor

adam.seegmiller@vanderbilt.edu
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Cell Regulation, University of Texas Southwestern Medical School, Dallas, TexasM.D., Medical Scientist, University of Texas Southwestern Medical School, Dallas, TexasB.S., University of Utah, Salt Lake City, Utah
Office Address
4918B TVC
1301 Medical Center Dr.
Nashville, TN 37232
Research Description
Cystic fibrosis (CF) is an inherited disease caused by mutations in the gene encoding CFTR, a chloride ion channel. Among the numerous consequences of these mutations are alterations in the composition of polyunsaturated fatty acids (PUFAs) in patient tissues. We have demonstrated that these changes are due to increased expression and activity of fatty acid desaturase enzymes. Furthermore, we and others have shown that these changes likely play a role in CF pathogenesis, perhaps through excessive production of eicosanoid hormones. We continue to investigate the regulation of PUFA metabolic pathways and the role that their function or dysfunction plays in the abnormal lipid metabolism of CF. In addition, we are studying the potential role of PUFAs both as biomarkers and therapies for patients with CF.
Research Keywords
Lipids Metabolism Cystic fibrosis Hematopathology
Clinical Research Keywords
Hematopathology Flow cytometry Hematologic malignancy Leukemia Lymphoma
Publications
Umunakwe OC, Seegmiller AC. Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase. J. Lipid Res [print-electronic]. 2014 May 5/24/2014; 55(7): 1489-97. PMID: 24859760, PMCID: PMC4076094, PII: jlr.M050369, DOI: 10.1194/jlr.M050369, ISSN: 0022-2275.

Seegmiller AC, Wasserman A, Kim AS, Kressin MK, Marx ER, Zutter MM, Mosse CA. Limited utility of fluorescence in situ hybridization for common abnormalities of myelodysplastic syndrome at first presentation and follow-up of myeloid neoplasms. Leuk. Lymphoma [print-electronic]. 2014 Mar; 55(3): 601-5. PMID: 23876099, DOI: 10.3109/10428194.2013.801470, ISSN: 1029-2403.

Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am. J. Clin. Pathol. 2013 Nov; 140(5): 643-50. PMID: 24124142, PMCID: PMC4159763, PII: 140/5/643, DOI: 10.1309/AJCP8CKE9NEINQFL, ISSN: 1943-7722.

Slone JS, Smith MC, Seegmiller AC, Sidonio RF, Yang E. Idiopathic myelofibrosis in children: primary myelofibrosis, essential thrombocythemia, or transient process?. J. Pediatr. Hematol. Oncol. 2013 Oct; 35(7): 559-65. PMID: 23799525, DOI: 10.1097/MPH.0b013e31829cdea0, ISSN: 1536-3678.

Katrangi W, Lawrenz J, Seegmiller AC, Laposata M. Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. Lipids [print-electronic]. 2013 Apr; 48(4): 333-42. PMID: 23440519, DOI: 10.1007/s11745-013-3768-4, ISSN: 1558-9307.

Castillo JJ, Furman M, Beltrán BE, Bibas M, Bower M, Chen W, Díez-Martín JL, Liu JJ, Miranda RN, Montoto S, Nanaji NM, Navarro JT, Seegmiller AC, Vose JM. Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy. Cancer [print-electronic]. 2012 Nov 11/1/2012; 118(21): 5270-7. PMID: 22510767, DOI: 10.1002/cncr.27551, ISSN: 1097-0142.

Njoroge SW, Laposata M, Katrangi W, Seegmiller AC. DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. J. Lipid Res [print-electronic]. 2012 Feb; 53(2): 257-65. PMID: 22095831, PMCID: PMC3269161, PII: jlr.M018101, DOI: 10.1194/jlr.M018101, ISSN: 0022-2275.

Gehrie E, Neff AT, Ciombor KK, Harris N, Seegmiller AC, Young PP. Transfusion medicine illustrated. Profound piperacillin-mediated drug-induced immune hemolysis in a patient with cystic fibrosis. Transfusion [print-electronic]. 2012 Jan; 52(1): 4-5. PMID: 22032241, DOI: 10.1111/j.1537-2995.2011.03407.x, ISSN: 1537-2995.

Thomsen KF, Laposata M, Njoroge SW, Umunakwe OC, Katrangi W, Seegmiller AC. Increased elongase 6 and ¿9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. Lipids [print-electronic]. 2011 Aug; 46(8): 669-77. PMID: 21544602, PMCID: PMC3711213, DOI: 10.1007/s11745-011-3563-z, ISSN: 1558-9307.

Njoroge SW, Seegmiller AC, Katrangi W, Laposata M. Increased ¿5- and ¿6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis. Biochim. Biophys. Acta [print-electronic]. 2011 Jul; 1811(7-8): 431-40. PMID: 21605700, PII: S1388-1981(11)00069-2, DOI: 10.1016/j.bbalip.2011.05.002, ISSN: 0006-3002.

Seegmiller AC, Wang HY, Hladik C, Chen W. Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma. Arch. Pathol. Lab. Med. 2011 Jun; 135(6): 770-5. PMID: 21631271, PII: 10.1043/2009-0691-OA.1, DOI: 10.1043/2009-0691-OA.1, ISSN: 1543-2165.

Seegmiller AC, Garcia R, Huang R, Maleki A, Karandikar NJ, Chen W. Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas. Mod. Pathol [print-electronic]. 2010 Jul; 23(7): 909-20. PMID: 20348878, PII: modpathol201076, DOI: 10.1038/modpathol.2010.76, ISSN: 1530-0285.

Qian Y, Wei C, Eun-Hyung Lee F, Campbell J, Halliley J, Lee JA, Cai J, Kong YM, Sadat E, Thomson E, Dunn P, Seegmiller AC, Karandikar NJ, Tipton CM, Mosmann T, Sanz I, Scheuermann RH. Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data. Cytometry B Clin Cytom. 2010; 78 Suppl 1: S69-82. PMID: 20839340, PMCID: PMC3084630, DOI: 10.1002/cyto.b.20554, ISSN: 1552-4957.

Seegmiller AC, Kroft SH, Karandikar NJ, McKenna RW. Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia. Am. J. Clin. Pathol. 2009 Dec; 132(6): 940-9. PMID: 19926587, PII: 132/6/940, DOI: 10.1309/AJCP8G5RMTWUEMUU, ISSN: 1943-7722.

Bogusz AM, Seegmiller AC, Garcia R, Shang P, Ashfaq R, Chen W. Plasmablastic lymphomas with MYC/IgH rearrangement: report of three cases and review of the literature. Am. J. Clin. Pathol. 2009 Oct; 132(4): 597-605. PMID: 19762538, PII: 132/4/597, DOI: 10.1309/AJCPFUR1BK0UODTS, ISSN: 1943-7722.

Maleki A, Seegmiller AC, Uddin N, Karandikar NJ, Chen W. Bright CD38 expression is an indicator of MYC rearrangement [letter]. Leuk. Lymphoma. 2009 Jun; 50(6): 1054-7. PMID: 19455464, PII: 911420847, DOI: 10.1080/10428190902930470, ISSN: 1029-2403.

Seegmiller AC, Karandikar NJ, Kroft SH, McKenna RW, Xu Y. Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes. Cytometry B Clin Cytom. 2009 May; 76(3): 169-74. PMID: 18956470, DOI: 10.1002/cyto.b.20459, ISSN: 1552-4957.

Seegmiller A, Sarode R. Laboratory evaluation of platelet function. Hematol. Oncol. Clin. North Am. 2007 Aug; 21(4): 731-42, vii. PMID: 17666287, PII: S0889-8588(07)00077-9, DOI: 10.1016/j.hoc.2007.06.008, ISSN: 0889-8588.

Seegmiller AC, Xu Y, McKenna RW, Karandikar NJ. Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma. Am. J. Clin. Pathol. 2007 Feb; 127(2): 176-81. PMID: 17210522, PII: 5R1J0127003380V2, DOI: 10.1309/5EL22BH45PHUPM8P, ISSN: 0002-9173.

Bennett MJ, Russell LK, Tokunaga C, Narayan SB, Tan L, Seegmiller A, Boriack RL, Strauss AW. Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase. Mol. Genet. Metab [print-electronic]. 2006 Sep; 89(1-2): 74-9. PMID: 16725361, PII: S1096-7192(06)00141-7, DOI: 10.1016/j.ymgme.2006.04.004, ISSN: 1096-7192.

Dobrosotskaya IY, Seegmiller AC, Brown MS, Goldstein JL, Rawson RB. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science. 2002 May 5/3/2002; 296(5569): 879-83. PMID: 11988566, PII: 296/5569/879, DOI: 10.1126/science.1071124, ISSN: 1095-9203.

Seegmiller AC, Dobrosotskaya I, Goldstein JL, Ho YK, Brown MS, Rawson RB. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev. Cell. 2002 Feb; 2(2): 229-38. PMID: 11832248, PII: S1534580701001198, ISSN: 1534-5807.

Sakai J, Rawson RB, Espenshade PJ, Cheng D, Seegmiller AC, Goldstein JL, Brown MS. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell. 1998 Oct; 2(4): 505-14. PMID: 9809072, PII: S1097-2765(00)80150-1, ISSN: 1097-2765.

Seegmiller A, Herrick G. A short internal eliminated sequence with central conserved sequences interrupting the LA-MSC gene of the 81 locus in the hypotrichous ciliates Oxytricha fallax and O. trifallax. J. Eukaryot. Microbiol. 1998 Jan; 45(1): 55-8. PMID: 9495033, ISSN: 1066-5234.

Witherspoon DJ, Doak TG, Williams KR, Seegmiller A, Seger J, Herrick G. Selection on the protein-coding genes of the TBE1 family of transposable elements in the ciliates Oxytricha fallax and O. trifallax. Mol. Biol. Evol. 1997 Jul; 14(7): 696-706. PMID: 9214742, ISSN: 0737-4038.

Seegmiller A, Williams KR, Herrick G. Two two-gene macronuclear chromosomes of the hypotrichous ciliates Oxytricha fallax and O. trifallax generated by alternative processing of the 81 locus. Dev. Genet. 1997; 20(4): 348-57. PMID: 9254909, PII: 10.1002/(SICI)1520-6408(1997)20:4<348::AID-DVG6>3.0.CO;2-7, DOI: 10.1002/(SICI)1520-6408(1997)20:4<348::AID-DVG6>3.0.CO;2-7, ISSN: 0192-253X.

Seegmiller A, Williams KR, Hammersmith RL, Doak TG, Witherspoon D, Messick T, Storjohann LL, Herrick G. Internal eliminated sequences interrupting the Oxytricha 81 locus: allelic divergence, conservation, conversions, and possible transposon origins. Mol. Biol. Evol. 1996 Dec; 13(10): 1351-62. PMID: 8952079, ISSN: 0737-4038.