Maralie G. Exton

Associate in
Faculty Appointments
Associate in Pathology, Microbiology and Immunology
B.A., Randolph-Macon Woman's College , Lynchburg, Virginia
Office Address
4605 TVC
TN 5310
Research Description
Research Keywords
Allied Health Programs
Exton JH. In search of the message. J. Biol. Chem [print-electronic]. 2008 May 5/30/2008; 283(22): 14901-9. PMID: 18378671, PMCID: PMC3258901, PII: X800001200, DOI: 10.1074/jbc.X800001200, ISSN: 0021-9258.

Brown HA, Henage LG, Preininger AM, Xiang Y, Exton JH. Biochemical analysis of phospholipase D. Meth. Enzymol. 2007; 434: 49-87. PMID: 17954242, PII: S0076-6879(07)34004-4, DOI: 10.1016/S0076-6879(07)34004-4, ISSN: 0076-6879.

Couvillon AD, Exton JH. Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells. Cell. Signal [print-electronic]. 2006 May; 18(5): 715-28. PMID: 16122906, PII: S0898-6568(05)00157-9, DOI: 10.1016/j.cellsig.2005.06.012, ISSN: 0898-6568.

Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol. Cell. Biol. 2006 Apr; 26(8): 3071-84. PMID: 16581782, PMCID: PMC1446932, PII: 26/8/3071, DOI: 10.1128/MCB.26.8.3071-3084.2006, ISSN: 0270-7306.

Henage LG, Exton JH, Brown HA. Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. J. Biol. Chem [print-electronic]. 2006 Feb 2/10/2006; 281(6): 3408-17. PMID: 16339153, PMCID: PMC3800466, PII: M508800200, DOI: 10.1074/jbc.M508800200, ISSN: 0021-9258.

Kook S, Exton JH. Identification of interaction sites of protein kinase Calpha on phospholipase D1. Cell. Signal. 2005 Nov; 17(11): 1423-32. PMID: 15951158, PII: S0898-6568(05)00053-7, DOI: 10.1016/j.cellsig.2005.03.003, ISSN: 0898-6568.

Chen JS, Exton JH. Sites on phospholipase D2 phosphorylated by PKCalpha. Biochem. Biophys. Res. Commun. 2005 Aug 8/12/2005; 333(4): 1322-6. PMID: 15979581, PII: S0006-291X(05)01243-X, DOI: 10.1016/j.bbrc.2005.06.048, ISSN: 0006-291X.

Hu T, Exton JH. A point mutation at phenylalanine 663 abolishes protein kinase C alpha's ability to translocate to the perinuclear region and activate phospholipase D1. Biochem. Biophys. Res. Commun. 2005 Aug 8/5/2005; 333(3): 750-3. PMID: 15963950, PII: S0006-291X(05)01150-2, DOI: 10.1016/j.bbrc.2005.05.184, ISSN: 0006-291X.

Ho WT, Xie Z, Zhao ZJ, Exton JH. Tyrosine phosphorylation of phospholipase D1 by v-Src does not per se result in activation. Cell. Signal. 2005 Jun; 17(6): 691-9. PMID: 15722193, PII: S0898-6568(04)00229-3, DOI: 10.1016/j.cellsig.2004.10.007, ISSN: 0898-6568.

Hiroyama M, Exton JH. Localization and regulation of phospholipase D2 by ARF6. J. Cell. Biochem. 2005 May 5/1/2005; 95(1): 149-64. PMID: 15759270, DOI: 10.1002/jcb.20351, ISSN: 0730-2312.

Hu T, Exton JH. 1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity. Biochem. Biophys. Res. Commun. 2005 Feb 2/25/2005; 327(4): 1047-51. PMID: 15652502, PII: S0006-291X(04)02882-7, DOI: 10.1016/j.bbrc.2004.12.117, ISSN: 0006-291X.

Buchanan FG, McReynolds M, Couvillon A, Kam Y, Holla VR, Dubois RN, Exton JH. Requirement of phospholipase D1 activity in H-RasV12-induced transformation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Feb 2/1/2005; 102(5): 1638-42. PMID: 15668389, PMCID: PMC547811, PII: 0406698102, DOI: 10.1073/pnas.0406698102, ISSN: 0027-8424.

Hiroyama M, Exton JH. Studies of the roles of ADP-ribosylation factors and phospholipase D in phorbol ester-induced membrane ruffling. J. Cell. Physiol. 2005 Feb; 202(2): 608-22. PMID: 15389577, DOI: 10.1002/jcp.20156, ISSN: 0021-9541.

Hu T, Exton JH. Protein kinase Calpha translocates to the perinuclear region to activate phospholipase D1. J. Biol. Chem [print-electronic]. 2004 Aug 8/20/2004; 279(34): 35702-8. PMID: 15187091, PII: M402372200, DOI: 10.1074/jbc.M402372200, ISSN: 0021-9258.

Chen JS, Exton JH. Regulation of phospholipase D2 activity by protein kinase C alpha. J. Biol. Chem [print-electronic]. 2004 May 5/21/2004; 279(21): 22076-83. PMID: 15031293, PII: M311033200, DOI: 10.1074/jbc.M311033200, ISSN: 0021-9258.

Kam Y, Exton JH. Role of phospholipase D in the activation of protein kinase D by lysophosphatidic acid. Biochem. Biophys. Res. Commun. 2004 Feb 2/27/2004; 315(1): 139-43. PMID: 15013437, PII: S0006291X04000622, DOI: 10.1016/j.bbrc.2004.01.034, ISSN: 0006-291X.

Kam Y, Exton JH. Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid. FASEB J. 2004 Feb; 18(2): 311-9. PMID: 14769825, PII: 18/2/311, DOI: 10.1096/fj.03-0731com, ISSN: 1530-6860.

Ho WT, Exton JH, Williger BT. Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. FEBS Lett. 2003 Feb 2/27/2003; 537(1-3): 91-5. PMID: 12606037, PII: S001457930300098X, ISSN: 0014-5793.

Hu T, Exton JH. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. J. Biol. Chem [print-electronic]. 2003 Jan 1/24/2003; 278(4): 2348-55. PMID: 12431982, PII: M210093200, DOI: 10.1074/jbc.M210093200, ISSN: 0021-9258.

Exton JH. Regulation of phospholipase D. FEBS Lett. 2002 Oct 10/30/2002; 531(1): 58-61. PMID: 12401203, PII: S0014579302034051, ISSN: 0014-5793.