James R. Goldenring, Ph.D., M.D.



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Faculty Appointments
Professor of Surgery Professor of Cell and Developmental BiologyPaul W. Sanger Chair in Experimental Surgery
M.D., Medicine, Yale University School of Medicine, New Haven, ConnecticutPh.D., Molec. Biophys. Biochem., Yale University, New Haven, ConnecticutA.B., Biomedical Sciences, Harvard University, Cambridge, Massachusetts
Office Address
10-435G MRB IV
2213 Garland Avenue
Nashville, TN 37232
Research Description
James R. Goldenring, MD, PhD

Dr. Goldenring’s research spans multiple topics across the broad area of epithelial biology. He has been a leader in investigation of the roles of specific roles of Rab small GTPases and their effectors in regulating vesicle trafficking, membrane recycling and polarity in polarized cells. His recent studies are focused on how these small GTPases may regulate cell polarity and the initiation of gastrointestinal cancers. He is presently studying the role of specific defects in apical vesicle trafficking in the etiology of neonatal diarrhea syndromes in human. His recently published work defined the role of Rab11a and Rab8a interactions with myosin Vb in the development of severe neonatal diarrhea in children with Microvillus Inclusion Disease and he has recently published work on the phenotypes of mouse models of MYO5B KO. The laboratory is now analyzing the newly developed mouse models for targeted loss of MYO5B, Rab11a and Rab11-FIP2 in the intestines and other organs. Other work in the Goldenring laboratory is defining the role of Par1b/MARK2 phosphorylation of Rab11-FIP1 and Rab11-FIP2 on the establishment and maintenance of polarity. These studies are utilizing phosphorylation site-specific antibodies as well as Rab11-FIP mutants to define defects in trafficking and polarity. Dr. GOldenring is alsoinbestigating the causes of congenital diarrheal diseases as one of the four lead investigators in the Pediatric Congenital Diarrhea Consortium (PediCODE).
In addition to his studies of epithelial polarity, Dr. Goldenring also studies the mechanisms responsible for the development of pre-neoplastic lineages from metaplasias in the stomach and their roles in gastric carcinogenesis. These investigations focus on defining how mature chief cells transdifferentiate into pre-neoplastic metaplasia in the stomach. Recent work has demonstrated that M2 macrophages are necessary for conversion of metaplasia into a proliferative and intestinalizing metaplasia. Other studies have demonstrated that activation of Ras is critical for multiple stages of induction and progression of metaplasia and may represent a focus for clinical intervention in gastric pre-cancer. On going studies focus on understanding the mechanisms responsible for the process of transdifferentiation and how immune regulators influence this process.

Research Keywords
Gastric cancer Vesicle trafficking Protein kinases Rab proteins A-kinase anchoring proteins Congenital diarrhea Neonatal Diarrhea Metaplasia Pre-cancer Centrosomes Golgi apparatus Membrane recycling Apical recycling systems Endocytosis Myosin V Gastric parietal cell Gastric metaplasia Epithelial biology RNA trafficking stress granules Cancer Protein structure
Clinical Research Keywords
Gastric Cancer Colon Cancer Neonatal Diarrhea
Lee SH, Contreras Panta EW, Gibbs D, Won Y, Min J, Zhang C, Roland JT, Hong SH, Sohn Y, Krystofiak E, Jang B, Ferri L, Sangwan V, Ragoussis J, Camilleri-Broët S, Caruso J, Chen-Tanyolac C, Strasser M, Gascard P, Tlsty TD, Huang S, Choi E, Goldenring JR. Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition. Gastroenterology [print-electronic]. 2023 Aug; 165(2): 374-90. PMID: 37196797, PMCID: PMC10375042, PII: S0016-5085(23)00731-X, DOI: 10.1053/j.gastro.2023.04.038, ISSN: 1528-0012.

Joseph I, Flores J, Farrell V, Davis J, Bianchi-Smak J, Feng Q, Goswami S, Lin X, Wei Z, Tong K, Feng Z, Verzi MP, Bonder EM, Goldenring JR, Gao N. RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells. EMBO Rep [print-electronic]. 2023 Jul 7/10/2023; e56240. PMID: 37424454, DOI: 10.15252/embr.202256240, ISSN: 1469-3178.

Goldenring JR. Spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer. J Pathol [print-electronic]. 2023 Jun; 260(2): 109-11. PMID: 37145865, PMCID: PMC10251156, DOI: 10.1002/path.6089, ISSN: 1096-9896.

Jeong H, Lee N, Uhm C, Cho K, Oh H, Oh Y, Zhang K, Kim HL, Goldenring JR, Lim KM, Park CO, Nam KT. RAB25 coordinates filaggrin-containing keratohyalin granule maturation and affects atopic dermatitis severity. Allergy [print-electronic]. 2023 Apr; 78(4): 1007-19. PMID: 36383036, DOI: 10.1111/all.15582, ISSN: 1398-9995.

Burman A, Momoh M, Sampson L, Skelton J, Roland JT, Ramos C, Krystofiak E, Acra S, Goldenring JR, Kaji I. Modeling of a Novel Patient-Based MYO5B Point Mutation Reveals Insights Into MVID Pathogenesis. Cell Mol Gastroenterol Hepatol [print-electronic]. 2023; 15(4): 1022-6. PMID: 36592862, PMCID: PMC10041088, PII: S2352-345X(22)00266-1, DOI: 10.1016/j.jcmgh.2022.12.015, ISSN: 2352-345X.

Peritore-Galve FC, Kaji I, Smith A, Walker LM, Shupe JA, Washington MK, Algood HMS, Dudeja PK, Goldenring JR, Lacy DB. Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection. Gut Microbes. 2023; 15(1): 2225841. PMID: 37350393, PMCID: PMC10291935, DOI: 10.1080/19490976.2023.2225841, ISSN: 1949-0984.

Min J, Zhang C, Bliton RJ, Caldwell B, Caplan L, Presentation KS, Park DJ, Kong SH, Lee HS, Washington MK, Kim WH, Lau KS, Magness ST, Lee HJ, Yang HK, Goldenring JR, Choi E. Dysplastic Stem Cell Plasticity Functions as a Driving Force for Neoplastic Transformation of Precancerous Gastric Mucosa. Gastroenterology [print-electronic]. 2022 Oct; 163(4): 875-90. PMID: 35700772, PMCID: PMC9509466, PII: S0016-5085(22)00626-6, DOI: 10.1053/j.gastro.2022.06.021, ISSN: 1528-0012.

Rathan-Kumar S, Roland JT, Momoh M, Goldstein A, Lapierre LA, Manning E, Mitchell L, Norman J, Kaji I, Goldenring JR. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage. Am J Physiol Gastrointest Liver Physiol [print-electronic]. 2022 Sep 9/1/2022; 323(3): G239-G254-G254. PMID: 35819177, PMCID: PMC9423785, DOI: 10.1152/ajpgi.00042.2022, ISSN: 1522-1547.

Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo E Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, DelGiorno KE. Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury. Gastroenterology [print-electronic]. 2022 Feb; 162(2): 604-620.e20-620.e20. PMID: 34695382, PMCID: PMC8792222, PII: S0016-5085(21)03665-9, DOI: 10.1053/j.gastro.2021.10.027, ISSN: 1528-0012.

Goldenring JR, Mills JC. Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond. Gastroenterology [print-electronic]. 2022 Feb; 162(2): 415-30. PMID: 34728185, PMCID: PMC8792220, PII: S0016-5085(21)03708-2, DOI: 10.1053/j.gastro.2021.10.036, ISSN: 1528-0012.

Lee SH, Jang B, Min J, Contreras-Panta EW, Presentation KS, Delgado AG, Piazuelo MB, Choi E, Goldenring JR. Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 13(1): 199-217. PMID: 34455107, PMCID: PMC8593616, PII: S2352-345X(21)00184-3, DOI: 10.1016/j.jcmgh.2021.08.017, ISSN: 2352-345X.

Bowman DM, Kaji I, Goldenring JR. Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular Level. Cell Mol Gastroenterol Hepatol [print-electronic]. 2022; 14(3): 553-65. PMID: 35660026, PMCID: PMC9304615, PII: S2352-345X(22)00098-4, DOI: 10.1016/j.jcmgh.2022.04.015, ISSN: 2352-345X.

Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell [print-electronic]. 2021 Dec 12/22/2021; 184(26): 6262-6280.e26-6280.e26. PMID: 34910928, PMCID: PMC8941949, PII: S0092-8674(21)01381-7, DOI: 10.1016/j.cell.2021.11.031, ISSN: 1097-4172.

Jacome-Sosa M, Miao ZF, Peche VS, Morris EF, Narendran R, Pietka KM, Samovski D, Lo HG, Pietka T, Varro A, Love-Gregory L, Goldenring JR, Kuda O, Gamazon ER, Mills JC, Abumrad NA. CD36 maintains the gastric mucosa and associates with gastric disease. Commun Biol. 2021 Nov 11/2/2021; 4(1): 1247. PMID: 34728772, PMCID: PMC8563937, PII: 10.1038/s42003-021-02765-z, DOI: 10.1038/s42003-021-02765-z, ISSN: 2399-3642.

Jeong H, Lee B, Kim KH, Cho SY, Cho Y, Park J, Lee Y, Oh Y, Hwang BR, Jang AR, Park JH, Park JH, Jeong SH, Lee D, Lee YC, Lim KM, Goldenring JR, Nam KT. WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury. Gastroenterology [print-electronic]. 2021 Sep; 161(3): 953-967.e15-967.e15. PMID: 34116028, PMCID: PMC8380710, PII: S0016-5085(21)03086-9, DOI: 10.1053/j.gastro.2021.05.058, ISSN: 1528-0012.

Kaji I, Roland JT, Rathan-Kumar S, Engevik AC, Burman A, Goldstein AE, Watanabe M, Goldenring JR. Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance. JCI Insight. 2021 Aug 8/23/2021; 6(16): PMID: 34197342, PMCID: PMC8409988, PII: e150416, DOI: 10.1172/jci.insight.150416, ISSN: 2379-3708.

Goswami S, Balasubramanian I, D'Agostino L, Bandyopadhyay S, Patel R, Avasthi S, Yu S, Goldenring JR, Bonder EM, Gao N. RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity. J Biol Chem [print-electronic]. 2021 Jul; 297(1): 100848. PMID: 34058200, PMCID: PMC8254046, PII: S0021-9258(21)00646-3, DOI: 10.1016/j.jbc.2021.100848, ISSN: 1083-351X.

McElvaine AT, Hawkins-Salsbury JA, Arora VM, Gladwin MT, Goldenring JR, Huston DP, Krakow D, Rhee K, Solway J, Steinman RA, Towler DA, Utz PJ, Yokoyama WM, Simpson RL, Muglia LJ, Permar SR, Gbadegesin RA. Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative. J Clin Invest. 2021 May 5/17/2021; 131(10): PMID: 33998594, PMCID: PMC8121502, PII: 149948, DOI: 10.1172/JCI149948, ISSN: 1558-8238.

Hess MW, Krainer IM, Filipek PA, Witting B, Gutleben K, Vietor I, Zoller H, Aldrian D, Sturm E, Goldenring JR, Janecke AR, Müller T, Huber LA, Vogel GF. Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations. J Clin Med. 2021 Apr 4/28/2021; 10(9): PMID: 33924896, PMCID: PMC8125609, PII: jcm10091901, DOI: 10.3390/jcm10091901, ISSN: 2077-0383.

De Salvo C, Pastorelli L, Petersen CP, Buttò LF, Buela KA, Omenetti S, Locovei SA, Ray S, Friedman HR, Duijser J, Xin W, Osme A, Cominelli F, Mahabeleshwar GH, Mills JC, Goldenring JR, Pizarro TT. Interleukin 33 Triggers Early Eosinophil-Dependent Events Leading to Metaplasia in a Chronic Model of Gastritis-Prone Mice. Gastroenterology [print-electronic]. 2021 Jan; 160(1): 302-316.e7-316.e7. PMID: 33010253, PMCID: PMC7755675, PII: S0016-5085(20)35223-9, DOI: 10.1053/j.gastro.2020.09.040, ISSN: 1528-0012.

Engevik AC, Krystofiak ES, Kaji I, Meyer AR, Weis VG, Goldstein A, Coutts AW, Melkamu T, Saqui-Salces M, Goldenring JR. Recruitment of Polarity Complexes and Tight Junction Proteins to the Site of Apical Bulk Endocytosis. Cell Mol Gastroenterol Hepatol [print-electronic]. 2021; 12(1): 59-80. PMID: 33548596, PMCID: PMC8082271, PII: S2352-345X(21)00028-X, DOI: 10.1016/j.jcmgh.2021.01.022, ISSN: 2352-345X.

Meyer AR, Engevik AC, Madorsky T, Belmont E, Stier MT, Norlander AE, Pilkinton MA, McDonnell WJ, Weis JA, Jang B, Mallal SA, Peebles RS, Goldenring JR. Group 2 Innate Lymphoid Cells Coordinate Damage Response in the Stomach. Gastroenterology [print-electronic]. 2020 Dec; 159(6): 2077-2091.e8-2091.e8. PMID: 32891625, PMCID: PMC7726005, PII: S0016-5085(20)35123-4, DOI: 10.1053/j.gastro.2020.08.051, ISSN: 1528-0012.

Kaji I, Roland JT, Watanabe M, Engevik AC, Goldstein AE, Hodges CA, Goldenring JR. Lysophosphatidic Acid Increases Maturation of Brush Borders and SGLT1 Activity in MYO5B-deficient Mice, a Model of Microvillus Inclusion Disease. Gastroenterology [print-electronic]. 2020 Oct; 159(4): 1390-1405.e20-1405.e20. PMID: 32534933, PMCID: PMC8240502, PII: S0016-5085(20)34760-0, DOI: 10.1053/j.gastro.2020.06.008, ISSN: 1528-0012.

Pinzon-Guzman C, Sangadala S, Riera KM, Popova EY, Manning E, Huh WJ, Alexander MS, Shelton JS, Boden SD, Goldenring JR. Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia. J Clin Invest. 2020 Aug 8/3/2020; 130(8): 4396-410. PMID: 32427591, PMCID: PMC7410075, PII: 123597, DOI: 10.1172/JCI123597, ISSN: 1558-8238.

LeBlanc C, Schlegel C, Robinson JR, Thomsen K, Goldenring JR, Acra S. The Financial Burden of an Undiagnosed Congenital Diarrhea Disorder [editorial]. J Pediatr Gastroenterol Nutr. 2020 Aug; 71(2): 145-6. PMID: 32304547, PMCID: PMC7597672, PII: 00005176-202008000-00001, DOI: 10.1097/MPG.0000000000002735, ISSN: 1536-4801.

Riera KM, Jang B, Min J, Roland JT, Yang Q, Fesmire WT, Camilleri-Broet S, Ferri L, Kim WH, Choi E, Goldenring JR. Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa. J Pathol [print-electronic]. 2020 Jul; 251(3): 336-47. PMID: 32432338, PMCID: PMC8010636, DOI: 10.1002/path.5469, ISSN: 1096-9896.

Engevik AC, Coutts AW, Kaji I, Rodriguez P, Ongaratto F, Saqui-Salces M, Medida RL, Meyer AR, Kolobova E, Engevik MA, Williams JA, Shub MD, Carlson DF, Melkamu T, Goldenring JR. Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-Lined Inclusions and Alterations in Sodium Transporters. Gastroenterology [print-electronic]. 2020 Jun; 158(8): 2236-2249.e9-2249.e9. PMID: 32112796, PMCID: PMC7282982, PII: S0016-5085(20)30261-4, DOI: 10.1053/j.gastro.2020.02.034, ISSN: 1528-0012.

Engevik AC, Kaji I, Goldenring JR. The Physiology of the Gastric Parietal Cell. Physiol Rev [print-electronic]. 2020 Apr 4/1/2020; 100(2): 573-602. PMID: 31670611, PMCID: PMC7327232, DOI: 10.1152/physrev.00016.2019, ISSN: 1522-1210.

Banan B, Beckstead JA, Dunavant LE, Sohn Y, Adcock JM, Nomura S, Abumrad N, Goldenring JR, Fingleton B. Development of a novel murine model of lymphatic metastasis. Clin Exp Metastasis [print-electronic]. 2020 Apr; 37(2): 247-55. PMID: 32052231, PMCID: PMC7979265, PII: 10.1007/s10585-020-10025-3, DOI: 10.1007/s10585-020-10025-3, ISSN: 1573-7276.

Goldenring JR. The challenge of personalized cell biology: The example of microvillus inclusion disease. Traffic [print-electronic]. 2020 Jan; 21(1): 169-71. PMID: 31596022, PMCID: PMC7597464, DOI: 10.1111/tra.12703, ISSN: 1600-0854.

Shimizu T, Sohn Y, Choi E, Petersen CP, Prasad N, Goldenring JR. Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation. Cell Mol Gastroenterol Hepatol [print-electronic]. 2020; 9(1): 61-78. PMID: 31473306, PMCID: PMC6881610, PII: S2352-345X(19)30114-6, DOI: 10.1016/j.jcmgh.2019.08.008, ISSN: 2352-345X.

Manning EH, Lapierre LA, Mills JC, Goldenring JR. Tamoxifen Acts as a Parietal Cell Protonophore [letter]. Cell Mol Gastroenterol Hepatol [print-electronic]. 2020; 10(3): 655-657.e1-657.e1. PMID: 32361017, PMCID: PMC7474156, PII: S2352-345X(20)30062-X, DOI: 10.1016/j.jcmgh.2020.04.012, ISSN: 2352-345X.

Min J, Vega PN, Engevik AC, Williams JA, Yang Q, Patterson LM, Simmons AJ, Bliton RJ, Betts JW, Lau KS, Magness ST, Goldenring JR, Choi E. Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach. Nat Commun. 2019 Dec 12/5/2019; 10(1): 5549. PMID: 31804471, PMCID: PMC6895174, PII: 10.1038/s41467-019-13479-6, DOI: 10.1038/s41467-019-13479-6, ISSN: 2041-1723.

Engevik AC, Kaji I, Postema MM, Faust JJ, Meyer AR, Williams JA, Fitz GN, Tyska MJ, Wilson JM, Goldenring JR. Loss of myosin Vb promotes apical bulk endocytosis in neonatal enterocytes. J Cell Biol [print-electronic]. 2019 Nov 11/4/2019; 218(11): 3647-62. PMID: 31562230, PMCID: PMC6829668, PII: jcb.201902063, DOI: 10.1083/jcb.201902063, ISSN: 1540-8140.

Jeong H, Lim KM, Goldenring JR, Nam KT. Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice. Biomol Ther (Seoul). 2019 Nov 11/1/2019; 27(6): 553-61. PMID: 31564077, PMCID: PMC6824620, PII: biomolther.2019.125, DOI: 10.4062/biomolther.2019.125, ISSN: 1976-9148.

Tonucci FM, Almada E, Borini-Etichetti C, Pariani A, Hidalgo F, Rico MJ, Girardini J, Favre C, Goldenring JR, Menacho-Marquez M, Larocca MC. Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis. Cancer Lett [print-electronic]. 2019 Oct 10/1/2019; 461: 65-77. PMID: 31319138, PII: S0304-3835(19)30402-1, DOI: 10.1016/j.canlet.2019.07.006, ISSN: 1872-7980.

Jeong H, Lim KM, Kim KH, Cho Y, Lee B, Knowles BC, Roland JT, Zwerner JP, Goldenring JR, Nam KT. Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking. J Pathol [print-electronic]. 2019 Oct; 249(2): 227-40. PMID: 31144312, PMCID: PMC8075409, DOI: 10.1002/path.5311, ISSN: 1096-9896.

D'Agostino L, Nie Y, Goswami S, Tong K, Yu S, Bandyopadhyay S, Flores J, Zhang X, Balasubramanian I, Joseph I, Sakamori R, Farrell V, Li Q, Yang CS, Gao B, Ferraris RP, Yehia G, Bonder EM, Goldenring JR, Verzi MP, Zhang L, Ip YT, Gao N. Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling. Cancer Res [print-electronic]. 2019 Aug 8/15/2019; 79(16): 4099-112. PMID: 31239271, PMCID: PMC6726494, PII: 0008-5472.CAN-18-4075, DOI: 10.1158/0008-5472.CAN-18-4075, ISSN: 1538-7445.

Goldenring JR. Membrane Trafficking Decisions Regulate Primary Cilium Formation. Trends Cell Biol [print-electronic]. 2019 Aug; 29(8): 607-8. PMID: 31221497, PII: S0962-8924(19)30099-6, DOI: 10.1016/j.tcb.2019.05.008, ISSN: 1879-3088.

Yang Q, Yasuda T, Choi E, Toyoda T, Roland JT, Uchida E, Yoshida H, Seto Y, Goldenring JR, Nomura S. MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils. Gastroenterology [print-electronic]. 2019 Feb; 156(3): 577-581.e4. PMID: 30391471, PMCID: PMC6368860, PII: S0016-5085(18)35206-5, DOI: 10.1053/j.gastro.2018.10.049, ISSN: 1528-0012.

Choi E, Means AL, Coffey RJ, Goldenring JR. Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 7(1): 251-253.e1. PMID: 30585163, PMCID: PMC6305842, PII: S2352-345X(18)30129-2, DOI: 10.1016/j.jcmgh.2018.09.007, ISSN: 2352-345X.

Meyer AR, Engevik AC, Willet SG, Williams JA, Zou Y, Massion PP, Mills JC, Choi E, Goldenring JR. Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 8(3): 379-405. PMID: 31071489, PMCID: PMC6713894, PII: S2352-345X(19)30060-8, DOI: 10.1016/j.jcmgh.2019.04.015, ISSN: 2352-345X.

Engevik AC, Kaji I, Engevik MA, Meyer AR, Weis VG, Goldstein A, Hess MW, Müller T, Koepsell H, Dudeja PK, Tyska M, Huber LA, Shub MD, Ameen N, Goldenring JR. Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes. Gastroenterology [print-electronic]. 2018 Dec; 155(6): 1883-1897.e10. PMID: 30144427, PMCID: PMC6279525, PII: S0016-5085(18)34890-X, DOI: 10.1053/j.gastro.2018.08.025, ISSN: 1528-0012.

Yu S, Yang M, Lim KM, Cho Y, Kim H, Lee K, Jeong SH, Coffey RJ, Goldenring JR, Nam KT. Expression of LRIG1, a Negative Regulator of EGFR, Is Dynamically Altered during Different Stages of Gastric Carcinogenesis. Am. J. Pathol [print-electronic]. 2018 Dec; 188(12): 2912-23. PMID: 30248341, PMCID: PMC6334257, PII: S0002-9440(18)30279-7, DOI: 10.1016/j.ajpath.2018.08.006, ISSN: 1525-2191.

Schlegel C, Lapierre LA, Weis VG, Williams JA, Kaji I, Pinzon-Guzman C, Prasad N, Boone B, Jones A, Correa H, Levy SE, Han X, Wang M, Thomsen K, Acra S, Goldenring JR. Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic [print-electronic]. 2018 Nov; 19(11): 879-92. PMID: 30095213, PMCID: PMC6191315, DOI: 10.1111/tra.12608, ISSN: 1600-0854.

Choi E, Lantz TL, Vlacich G, Keeley TM, Samuelson LC, Coffey RJ, Goldenring JR, Powell AE. Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut [print-electronic]. 2018 Sep; 67(9): 1595-605. PMID: 28814482, PMCID: PMC5815959, PII: gutjnl-2017-313874, DOI: 10.1136/gutjnl-2017-313874, ISSN: 1468-3288.

Meyer AR, Goldenring JR. Injury, repair, inflammation and metaplasia in the stomach. J. Physiol. (Lond.) [print-electronic]. 2018 Sep; 596(17): 3861-7. PMID: 29427515, PMCID: PMC6117566, DOI: 10.1113/JP275512, ISSN: 1469-7793.

Pinzon-Guzman C, Meyer AR, Wise R, Choi E, Muthupalani S, Wang TC, Fox JG, Goldenring JR. Evaluation of Lineage Changes in the Gastric Mucosa Following Infection With Helicobacter pylori and Specified Intestinal Flora in INS-GAS Mice. J. Histochem. Cytochem [print-electronic]. 2018 Jul 7/1/2018; 22155418785621. PMID: 29969055, PMCID: PMC6309034, DOI: 10.1369/0022155418785621, ISSN: 1551-5044.

Goldenring JR. Pyloric metaplasia, pseudopyloric metaplasia, ulcer-associated cell lineage and spasmolytic polypeptide-expressing metaplasia: reparative lineages in the gastrointestinal mucosa. J. Pathol [print-electronic]. 2018 Jun; 245(2): 132-7. PMID: 29508389, PMCID: PMC6026529, DOI: 10.1002/path.5066, ISSN: 1096-9896.

Thiagarajah JR, Kamin DS, Acra S, Goldsmith JD, Roland JT, Lencer WI, Muise AM, Goldenring JR, Avitzur Y, Martín MG, . Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology [print-electronic]. 2018 Jun; 154(8): 2045-2059.e6. PMID: 29654747, PMCID: PMC6044208, PII: S0016-5085(18)30440-2, DOI: 10.1053/j.gastro.2018.03.067, ISSN: 1528-0012.

Petersen CP, Meyer AR, De Salvo C, Choi E, Schlegel C, Petersen A, Engevik AC, Prasad N, Levy SE, Peebles RS, Pizarro TT, Goldenring JR. A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut [print-electronic]. 2018 May; 67(5): 805-17. PMID: 28196875, PMCID: PMC5681443, PII: gutjnl-2016-312779, DOI: 10.1136/gutjnl-2016-312779, ISSN: 1468-3288.

Yamamoto M, Nomura S, Hosoi A, Nagaoka K, Iino T, Yasuda T, Saito T, Matsushita H, Uchida E, Seto Y, Goldenring JR, Kakimi K, Tatematsu M, Tsukamoto T. Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth. Cancer Sci [print-electronic]. 2018 May; 109(5): 1480-92. PMID: 29532565, PMCID: PMC5980194, DOI: 10.1111/cas.13569, ISSN: 1349-7006.

Kirschman J, Qi M, Ding L, Hammonds J, Dienger-Stambaugh K, Wang JJ, Lapierre LA, Goldenring JR, Spearman P. HIV-1 Envelope Glycoprotein Trafficking through the Endosomal Recycling Compartment Is Required for Particle Incorporation. J. Virol [electronic-print]. 2018 Mar 3/1/2018; 92(5): PMID: 29212940, PMCID: PMC5809729, PII: JVI.01893-17, DOI: 10.1128/JVI.01893-17, ISSN: 1098-5514.

Schlegel C, Weis VG, Knowles BC, Lapierre LA, Martin MG, Dickman P, Goldenring JR, Shub MD. Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig. Dis. Sci [print-electronic]. 2018 Feb; 63(2): 356-65. PMID: 29218485, PMCID: PMC5797493, PII: 10.1007/s10620-017-4867-5, DOI: 10.1007/s10620-017-4867-5, ISSN: 1573-2568.

Engevik AC, Goldenring JR. Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes. Cold Spring Harb Perspect Biol. 2018 Jan 1/2/2018; 10(1): PMID: 28264818, PMCID: PMC5683927, PII: cshperspect.a027979, DOI: 10.1101/cshperspect.a027979, ISSN: 1943-0264.

Bockerstett KA, Osaki LH, Petersen CP, Cai CW, Wong CF, Nguyen TM, Ford EL, Hoft DF, Mills JC, Goldenring JR, DiPaolo RJ. Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis. Cell Mol Gastroenterol Hepatol. 2018; 5(4): 678-690.e1. PMID: 29930985, PMCID: PMC6009015, PII: S2352-345X(17)30191-1, DOI: 10.1016/j.jcmgh.2017.12.012, ISSN: 2352-345X.

Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol. 2018; 6(3): 257-76. PMID: 30109253, PMCID: PMC6083016, PII: S2352-345X(18)30082-1, DOI: 10.1016/j.jcmgh.2018.05.006, ISSN: 2352-345X.

Engevik AC, Goldenring JR. Modeling Microvillus Inclusion Formation In Vitro [editorial]. Cell Mol Gastroenterol Hepatol. 2018; 6(4): 472-3. PMID: 30364797, PMCID: PMC6198021, PII: S2352-345X(18)30114-0, DOI: 10.1016/j.jcmgh.2018.08.002, ISSN: 2352-345X.

Nomura S, Goldenring JR. Mind the Gap: Crossing Boundaries to Establish Reparative Metaplasia [editorial]. Cell Mol Gastroenterol Hepatol. 2018; 6(4): 468-9. PMID: 30364646, PMCID: PMC6198020, PII: S2352-345X(18)30105-X, DOI: 10.1016/j.jcmgh.2018.07.002, ISSN: 2352-345X.

Kolobova E, Roland JT, Lapierre LA, Williams JA, Mason TA, Goldenring JR. The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins. J. Biol. Chem [print-electronic]. 2017 Dec 12/15/2017; 292(50): 20394-409. PMID: 29054927, PMCID: PMC5733579, PII: M117.806018, DOI: 10.1074/jbc.M117.806018, ISSN: 1083-351X.

Kim SW, Ehrman J, Ahn MR, Kondo J, Lopez AAM, Oh YS, Kim XH, Crawley SW, Goldenring JR, Tyska MJ, Rericha EC, Lau KS. Shear stress induces noncanonical autophagy in intestinal epithelial monolayers. Mol. Biol. Cell [print-electronic]. 2017 Nov 11/1/2017; 28(22): 3043-56. PMID: 28855375, PMCID: PMC5662261, PII: mbc.E17-01-0021, DOI: 10.1091/mbc.E17-01-0021, ISSN: 1939-4586.

Bertaux-Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, Sundaram N, Gabre J, Hawkins J, Jian G, Engevik AC, Yang L, Wang J, Goldenring JR, Qualls JE, Medvedovic M, Helmrath MA, Diwan T, Mulloy JC, Zavros Y. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J. Pathol. 2017 Aug; 242(4): 463-75. PMID: 28497484, PMCID: PMC5591948, DOI: 10.1002/path.4918, ISSN: 1096-9896.

Feng Q, Bonder EM, Engevik AC, Zhang L, Tyska MJ, Goldenring JR, Gao N. Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy. J. Cell. Sci [print-electronic]. 2017 Aug 8/1/2017; 130(15): 2491-505. PMID: 28596241, PMCID: PMC5558269, PII: jcs.201897, DOI: 10.1242/jcs.201897, ISSN: 1477-9137.

Choi B, Lee HJ, Min J, Choe HN, Choi YS, Son YG, Ahn HS, Suh YS, Goldenring JR, Yang HK. Plasma expression of the intestinal metaplasia markers CDH17 and TFF3 in patients with gastric cancer. Cancer Biomark. 2017 Jul 7/4/2017; 19(3): 231-9. PMID: 28453457, PII: CBM160147, DOI: 10.3233/CBM-160147, ISSN: 1875-8592.

Vogel GF, Janecke AR, Krainer IM, Gutleben K, Witting B, Mitton SG, Mansour S, Ballauff A, Roland JT, Engevik AC, Cutz E, Müller T, Goldenring JR, Huber LA, Hess MW. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease. Traffic [print-electronic]. 2017 Jul; 18(7): 453-64. PMID: 28407399, PMCID: PMC5693299, DOI: 10.1111/tra.12486, ISSN: 1600-0854.

Mills JC, Goldenring JR. Metaplasia in the Stomach Arises From Gastric Chief Cells. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1): 85-8. PMID: 28560292, PMCID: PMC5440355, PII: S2352-345X(17)30052-8, DOI: 10.1016/j.jcmgh.2017.03.006, ISSN: 2352-345X.

Lapierre LA, Manning EH, Mitchell KM, Caldwell CM, Goldenring JR. Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition. Mol. Biol. Cell [print-electronic]. 2017 Apr 4/15/2017; 28(8): 1088-100. PMID: 28228550, PMCID: PMC5391185, PII: mbc.E16-04-0214, DOI: 10.1091/mbc.E16-04-0214, ISSN: 1939-4586.

Burclaff J, Osaki LH, Liu D, Goldenring JR, Mills JC. Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach. Gastroenterology [print-electronic]. 2017 Mar; 152(4): 762-766.e7. PMID: 27932312, PMCID: PMC5391042, PII: S0016-5085(16)35446-4, DOI: 10.1053/j.gastro.2016.12.001, ISSN: 1528-0012.

Jeong S, Choi E, Petersen CP, Roland JT, Federico A, Ippolito R, D'Armiento FP, Nardone G, Nagano O, Saya H, Romano M, Goldenring JR. Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. United European Gastroenterol J [print-electronic]. 2017 Feb; 5(1): 37-44. PMID: 28405320, PMCID: PMC5384548, PII: 10.1177_2050640616644142, DOI: 10.1177/2050640616644142, ISSN: 2050-6406.

Petersen CP, Mills JC, Goldenring JR. Murine Models of Gastric Corpus Preneoplasia. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1): 11-26. PMID: 28174755, PMCID: PMC5247421, PII: S2352-345X(16)30128-X, DOI: 10.1016/j.jcmgh.2016.11.001, ISSN: 2352-345X.

Goldenring JR, Mills JC. Isthmus Time Is Here: Runx1 Identifies Mucosal Stem Cells in the Gastric Corpus [editorial]. Gastroenterology [print-electronic]. 2017 Jan; 152(1): 16-9. PMID: 27889575, PII: S0016-5085(16)35397-5, DOI: 10.1053/j.gastro.2016.11.028, ISSN: 1528-0012.

Weis VG, Petersen CP, Weis JA, Meyer AR, Choi E, Mills JC, Goldenring JR. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2017 Jan 1/1/2017; 312(1): G67-G76. PMID: 27881402, PMCID: PMC5283902, PII: ajpgi.00326.2016, DOI: 10.1152/ajpgi.00326.2016, ISSN: 1522-1547.

O'Neil A, Petersen CP, Choi E, Engevik AC, Goldenring JR. Unique Cellular Lineage Composition of the First Gland of the Mouse Gastric Corpus. J. Histochem. Cytochem [print-electronic]. 2017 Jan; 65(1): 47-58. PMID: 27872404, PMCID: PMC5256201, PII: 0022155416678182, DOI: 10.1369/0022155416678182, ISSN: 1551-5044.

McRae R, Lapierre LA, Manning EH, Goldenring JR. Rab11-FIP1 phosphorylation by MARK2 regulates polarity in MDCK cells. Cell Logist. 2017; 7(1): e1271498. PMID: 28396819, PMCID: PMC5383218, PII: 1271498, DOI: 10.1080/21592799.2016.1271498, ISSN: 2159-2780.

Engevik AC, Feng R, Choi E, White S, Bertaux-Skeirik N, Li J, Mahe MM, Aihara E, Yang L, DiPasquale B, Oh S, Engevik KA, Giraud AS, Montrose MH, Medvedovic M, Helmrath MA, Goldenring JR, Zavros Y. The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5): 605-24. PMID: 27990460, PMCID: PMC5042762, PII: S2352-345X(16)30044-3, DOI: 10.1016/j.jcmgh.2016.05.004, ISSN: 2352-345X.

Goldenring JR. What Ever Happened to the Scientific Conversation? [editorial]. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3): 251-2. PMID: 28174713, PMCID: PMC5042362, PII: S2352-345X(16)30007-8, DOI: 10.1016/j.jcmgh.2016.03.003, ISSN: 2352-345X.

Shimizu T, Choi E, Petersen CP, Noto JM, Romero-Gallo J, Piazuelo MB, Washington MK, Peek RM, Goldenring JR. Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori. J. Pathol [print-electronic]. 2016 Apr 4/29/2016; PMID: 27125972, DOI: 10.1002/path.4735, ISSN: 1096-9896.

Weis GV, Knowles BC, Choi E, Goldstein AE, Williams JA, Manning EH, Roland JT, Lapierre LA, Goldenring JR. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016 Feb 2/1/2016; 2(2): 131-57. PMID: 27019864, PMCID: PMC4806369, DOI: 10.1016/j.jcmgh.2015.11.009, ISSN: 2352-345X.

Schafer JC, McRae RE, Manning EH, Lapierre LA, Goldenring JR. Rab11-FIP1A regulates early trafficking into the recycling endosomes. Exp. Cell Res [print-electronic]. 2016 Jan 1/15/2016; 340(2): 259-73. PMID: 26790954, PMCID: PMC4744548, PII: S0014-4827(16)30004-0, DOI: 10.1016/j.yexcr.2016.01.003, ISSN: 1090-2422.

Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR. Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology [print-electronic]. 2015 Dec 12/8/2015; PMID: 26677984, PII: S0016-5085(15)01735-7, DOI: 10.1053/j.gastro.2015.11.049, ISSN: 1528-0012.

Singh B, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, Coffey RJ. Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin. J. Cell. Sci [print-electronic]. 2015 Sep 9/15/2015; 128(18): 3444-55. PMID: 26272915, PMCID: PMC4582402, PII: jcs.170852, DOI: 10.1242/jcs.170852, ISSN: 1477-9137.

Tonucci FM, Hidalgo F, Ferretti A, Almada E, Favre C, Goldenring JR, Kaverina I, Kierbel A, Larocca MC. Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells. J. Cell. Sci [print-electronic]. 2015 Sep 9/1/2015; 128(17): 3277-89. PMID: 26208639, PMCID: PMC4582191, PII: jcs.170878, DOI: 10.1242/jcs.170878, ISSN: 1477-9137.

Choi E, Petersen CP, Lapierre LA, Williams JA, Weis VG, Goldenring JR, Nam KT. Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin. Am. J. Pathol [print-electronic]. 2015 Aug; 185(8): 2219-31. PMID: 26073039, PMCID: PMC4530133, PII: S0002-9440(15)00267-9, DOI: 10.1016/j.ajpath.2015.04.009, ISSN: 1525-2191.

Goldenring JR. Recycling endosomes. Curr. Opin. Cell Biol [print-electronic]. 2015 Aug; 35: 117-22. PMID: 26022676, PMCID: PMC4529760, PII: S0955-0674(15)00059-9, DOI: 10.1016/j.ceb.2015.04.018, ISSN: 1879-0410.

Goldenring JR. Referential Obfuscation: Contemplations on the Ethics of Impact [editorial]. Cell Mol Gastroenterol Hepatol. 2015 Jul; 1(4): 346-7. PMID: 28210684, PMCID: PMC5301289, PII: S2352-345X(15)00103-4, DOI: 10.1016/j.jcmgh.2015.06.001, ISSN: 2352-345X.

Seishima R, Wada T, Tsuchihashi K, Okazaki S, Yoshikawa M, Oshima H, Oshima M, Sato T, Hasegawa H, Kitagawa Y, Goldenring JR, Saya H, Nagano O. Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis. Cancer Prev Res (Phila) [print-electronic]. 2015 Jun; 8(6): 492-501. PMID: 25813526, PII: 1940-6207.CAPR-15-0025-T, DOI: 10.1158/1940-6207.CAPR-15-0025-T, ISSN: 1940-6215.

Knowles BC, Weis VG, Yu S, Roland JT, Williams JA, Alvarado GS, Lapierre LA, Shub MD, Gao N, Goldenring JR. Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes. J. Cell. Sci [print-electronic]. 2015 Apr 4/15/2015; 128(8): 1617-26. PMID: 25673875, PMCID: PMC4518445, PII: jcs.163303, DOI: 10.1242/jcs.163303, ISSN: 1477-9137.

Sousa JF, Nam KT, Petersen CP, Lee HJ, Yang HK, Kim WH, Goldenring JR. MiR-30-HNF4¿ and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach. Gut [print-electronic]. 2015 Mar 3/23/2015; PMID: 25800782, PII: gutjnl-2014-308759, DOI: 10.1136/gutjnl-2014-308759, ISSN: 1468-3288.

Choi E, Roland JT, Barlow BJ, O'Neal R, Rich AE, Nam KT, Shi C, Goldenring JR. Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut [print-electronic]. 2014 Nov; 63(11): 1711-20. PMID: 24488499, PMCID: PMC4117823, PII: gutjnl-2013-305964, DOI: 10.1136/gutjnl-2013-305964, ISSN: 1468-3288.

Weis VG, Petersen CP, Mills JC, Tuma PL, Whitehead RH, Goldenring JR. Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2014 Oct 10/15/2014; 307(8): G777-92. PMID: 25190476, PMCID: PMC4200317, PII: ajpgi.00169.2014, DOI: 10.1152/ajpgi.00169.2014, ISSN: 1522-1547.

Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N. TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J [print-electronic]. 2014 Sep 9/1/2014; 33(17): 1882-95. PMID: 25063677, PMCID: PMC4195784, PII: embj.201487888, DOI: 10.15252/embj.201487888, ISSN: 1460-2075.

Mason TA, Goldenring JR, Kolobova E. AKAP350C targets to mitochondria via a novel amphipathic alpha helical domain. Cell Logist. 2014 Jul; 4(3): e943597. PMID: 25610720, PMCID: PMC4279805, PII: 943597, DOI: 10.4161/21592780.2014.943597, ISSN: 2159-2780.

Knowles BC, Tyska MJ, Goldenring JR. Apical vesicle trafficking takes center stage in neonatal enteropathies [editorial]. Gastroenterology. 2014 Jul; 147(1): 15-7. PMID: 24954664, PII: S0016-5085(14)00676-3, DOI: 10.1053/j.gastro.2014.05.028, ISSN: 1528-0012.

Petersen CP, Weis VG, Nam KT, Sousa JF, Fingleton B, Goldenring JR. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology [print-electronic]. 2014 Jun; 146(7): 1727-38.e8. PMID: 24534633, PMCID: PMC4035414, PII: S0016-5085(14)00218-2, DOI: 10.1053/j.gastro.2014.02.007, ISSN: 1528-0012.

Goldenring JR. Gastric intestinal metaplasia and tamoxifen: can we reverse the inevitable? [editorial]. Dig. Dis. Sci. 2014 Jun; 59(6): 1078-9. PMID: 24595657, DOI: 10.1007/s10620-014-3088-4, ISSN: 1573-2568.

Schafer JC, Baetz NW, Lapierre LA, McRae RE, Roland JT, Goldenring JR. Rab11-FIP2 interaction with MYO5B regulates movement of Rab11a-containing recycling vesicles. Traffic [print-electronic]. 2014 Mar; 15(3): 292-308. PMID: 24372966, PMCID: PMC4081500, DOI: 10.1111/tra.12146, ISSN: 1600-0854.

Baetz NW, Goldenring JR. Distinct patterns of phosphatidylserine localization within the Rab11a-containing recycling system. Cell Logist. 2014; 4: e28680. PMID: 25210648, PMCID: PMC4156484, PII: 2013CELLULARLOG0022R, DOI: 10.4161/cl.28680, ISSN: 2159-2780.

Farrow MA, Chumbler NM, Lapierre LA, Franklin JL, Rutherford SA, Goldenring JR, Lacy DB. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 Nov 11/12/2013; 110(46): 18674-9. PMID: 24167244, PMCID: PMC3831945, PII: 1313658110, DOI: 10.1073/pnas.1313658110, ISSN: 1091-6490.

Goldenring JR. A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis. Nat. Rev. Cancer [print-electronic]. 2013 Nov; 13(11): 813-20. PMID: 24108097, PMCID: PMC4011841, PII: nrc3601, DOI: 10.1038/nrc3601, ISSN: 1474-1768.

Weis VG, Sousa JF, LaFleur BJ, Nam KT, Weis JA, Finke PE, Ameen NA, Fox JG, Goldenring JR. Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression. Gut [print-electronic]. 2013 Sep; 62(9): 1270-9. PMID: 22773549, PMCID: PMC3762676, PII: gutjnl-2012-302401, DOI: 10.1136/gutjnl-2012-302401, ISSN: 1468-3288.

O'Neal RL, Nam KT, LaFleur BJ, Barlow B, Nozaki K, Lee HJ, Kim WH, Yang HK, Shi C, Maitra A, Montgomery E, Washington MK, El Rifai W, Drapkin RI, Goldenring JR. Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. Hum. Pathol [print-electronic]. 2013 May; 44(5): 734-42. PMID: 23084584, PMCID: PMC3556378, PII: S0046-8177(12)00275-4, DOI: 10.1016/j.humpath.2012.07.017, ISSN: 1532-8392.

Krishnan M, Lapierre LA, Knowles BC, Goldenring JR. Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol. Biol. Cell [print-electronic]. 2013 Mar; 24(6): 818-31. PMID: 23345591, PMCID: PMC3596252, PII: mbc.E12-10-0745, DOI: 10.1091/mbc.E12-10-0745, ISSN: 1939-4586.

Baetz NW, Goldenring JR. Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system. Mol. Biol. Cell [print-electronic]. 2013 Mar; 24(5): 643-58. PMID: 23283983, PMCID: PMC3583667, PII: mbc.E12-09-0659, DOI: 10.1091/mbc.E12-09-0659, ISSN: 1939-4586.

Mattaloni SM, Ferretti AC, Tonucci FM, Favre C, Goldenring JR, Larocca MC. Centrosomal AKAP350 modulates the G1/S transition. Cell Logist. 2013 Jan 1/1/2013; 3(1): e26331. PMID: 24475373, PMCID: PMC3891632, PII: 2013CELLULARLOG0008R, DOI: 10.4161/cl.26331, ISSN: 2159-2780.

Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM. Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS ONE [print-electronic]. 2013; 8(1): e54344. PMID: 23372710, PMCID: PMC3553174, PII: PONE-D-12-20127, DOI: 10.1371/journal.pone.0054344, ISSN: 1932-6203.

Nam KT, O'Neal RL, Coffey RJ, Finke PE, Barker N, Goldenring JR. Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut [print-electronic]. 2012 Dec; 61(12): 1678-85. PMID: 22198711, PMCID: PMC3767919, PII: gutjnl-2011-301193, DOI: 10.1136/gutjnl-2011-301193, ISSN: 1468-3288.

Sousa JF, Ham AJ, Whitwell C, Nam KT, Lee HJ, Yang HK, Kim WH, Zhang B, Li M, LaFleur B, Liebler DC, Goldenring JR. Proteomic profiling of paraffin-embedded samples identifies metaplasia-specific and early-stage gastric cancer biomarkers. Am. J. Pathol [print-electronic]. 2012 Nov; 181(5): 1560-72. PMID: 22944598, PMCID: PMC3483808, PII: S0002-9440(12)00597-4, DOI: 10.1016/j.ajpath.2012.07.027, ISSN: 1525-2191.

Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR. Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells. Mol. Biol. Cell [print-electronic]. 2012 Jun; 23(12): 2302-18. PMID: 22553350, PMCID: PMC3374749, PII: mbc.E11-08-0681, DOI: 10.1091/mbc.E11-08-0681, ISSN: 1939-4586.

Nam KT, O'Neal R, Lee YS, Lee YC, Coffey RJ, Goldenring JR. Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature. Lab. Invest [print-electronic]. 2012 Jun; 92(6): 883-95. PMID: 22411066, PMCID: PMC3584162, PII: labinvest201247, DOI: 10.1038/labinvest.2012.47, ISSN: 1530-0307.

Lapierre LA, Ducharme NA, Drake KR, Goldenring JR, Kenworthy AK. Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells. Exp. Cell Res [print-electronic]. 2012 Jan 1/15/2012; 318(2): 103-13. PMID: 22036648, PMCID: PMC3230713, PII: S0014-4827(11)00407-1, DOI: 10.1016/j.yexcr.2011.10.010, ISSN: 1090-2422.

Mattaloni SM, Kolobova E, Favre C, Marinelli RA, Goldenring JR, Larocca MC. AKAP350 Is involved in the development of apical "canalicular" structures in hepatic cells HepG2. J. Cell. Physiol. 2012 Jan; 227(1): 160-71. PMID: 21374596, PMCID: PMC3899033, DOI: 10.1002/jcp.22713, ISSN: 1097-4652.

Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam DB, Goldenring JR, Lacy DB. Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog [print-electronic]. 2012; 8(12): e1003072. PMID: 23236283, PMCID: PMC3516567, PII: PPATHOGENS-D-12-01408, DOI: 10.1371/journal.ppat.1003072, ISSN: 1553-7374.

Shaikh FY, Utley TJ, Craven RE, Rogers MC, Lapierre LA, Goldenring JR, Crowe JE. Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins. PLoS ONE [print-electronic]. 2012; 7(7): e40826. PMID: 22808269, PMCID: PMC3396619, PII: PONE-D-12-11914, DOI: 10.1371/journal.pone.0040826, ISSN: 1932-6203.

Goldenring JR, Nam KT, Mills JC. The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist. Exp. Cell Res [print-electronic]. 2011 Nov 11/15/2011; 317(19): 2759-64. PMID: 21907708, PMCID: PMC3210373, PII: S0014-4827(11)00340-5, DOI: 10.1016/j.yexcr.2011.08.017, ISSN: 1090-2422.

Aikou S, Ohmoto Y, Gunji T, Matsuhashi N, Ohtsu H, Miura H, Kubota K, Yamagata Y, Seto Y, Nakajima A, Goldenring JR, Kaminishi M, Nomura S. Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening. Gastroenterology [print-electronic]. 2011 Sep; 141(3): 837-845.e1. PMID: 21699780, PMCID: PMC3163741, PII: S0016-5085(11)00705-0, DOI: 10.1053/j.gastro.2011.05.040, ISSN: 1528-0012.

Ducharme NA, Ham AJ, Lapierre LA, Goldenring JR. Rab11-FIP2 influences multiple components of the endosomal system in polarized MDCK cells. Cell Logist. 2011 Mar; 1(2): 57-68. PMID: 21686255, PMCID: PMC3116584, PII: 2159-2780-1-2-5, DOI: 10.4161/cl.1.2.15289, ISSN: 2159-2780.

Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Feb 2/15/2011; 108(7): 2789-94. PMID: 21282656, PMCID: PMC3041130, PII: 1010754108, DOI: 10.1073/pnas.1010754108, ISSN: 1091-6490.

Lapierre LA, Caldwell CM, Higginbotham JN, Avant KM, Hall J, Beauchamp RD, Goldenring JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken) [print-electronic]. 2011 Feb; 68(2): 97-111. PMID: 21246754, PMCID: PMC3885764, DOI: 10.1002/cm.20497, ISSN: 1949-3592.

Goldenring JR, Nam KT. Rab25 as a tumour suppressor in colon carcinogenesis. Br. J. Cancer [print-electronic]. 2011 Jan 1/4/2011; 104(1): 33-6. PMID: 21063400, PMCID: PMC3039820, PII: 6605983, DOI: 10.1038/sj.bjc.6605983, ISSN: 1532-1827.

Mason TA, Kolobova E, Liu J, Roland JT, Chiang C, Goldenring JR. Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. PLoS ONE [print-electronic]. 2011; 6(11): e27699. PMID: 22110729, PMCID: PMC3216988, PII: PONE-D-11-15023, DOI: 10.1371/journal.pone.0027699, ISSN: 1932-6203.

Nam KT, Lee HJ, Sousa JF, Weis VG, O'Neal RL, Finke PE, Romero-Gallo J, Shi G, Mills JC, Peek RM, Konieczny SF, Goldenring JR. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology [print-electronic]. 2010 Dec; 139(6): 2028-2037.e9. PMID: 20854822, PMCID: PMC2997152, PII: S0016-5085(10)01321-1, DOI: 10.1053/j.gastro.2010.09.005, ISSN: 1528-0012.

Shinohara M, Mao M, Keeley TM, El-Zaatari M, Lee HJ, Eaton KA, Samuelson LC, Merchant JL, Goldenring JR, Todisco A. Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology [print-electronic]. 2010 Dec; 139(6): 2050-2060.e2. PMID: 20826155, PMCID: PMC3039550, PII: S0016-5085(10)01302-8, DOI: 10.1053/j.gastro.2010.08.052, ISSN: 1528-0012.

Quante M, Marrache F, Goldenring JR, Wang TC. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology [print-electronic]. 2010 Dec; 139(6): 2018-2027.e2. PMID: 20708616, PMCID: PMC2997174, PII: S0016-5085(10)01170-4, DOI: 10.1053/j.gastro.2010.08.003, ISSN: 1528-0012.

Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am. J. Pathol [print-electronic]. 2010 Sep; 177(3): 1514-33. PMID: 20709804, PMCID: PMC2928982, PII: S0002-9440(10)60203-9, DOI: 10.2353/ajpath.2010.100328, ISSN: 1525-2191.

Lee HJ, Nam KT, Park HS, Kim MA, Lafleur BJ, Aburatani H, Yang HK, Kim WH, Goldenring JR. Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology [print-electronic]. 2010 Jul; 139(1): 213-25.e3. PMID: 20398667, PMCID: PMC2917327, PII: S0016-5085(10)00554-8, DOI: 10.1053/j.gastro.2010.04.008, ISSN: 1528-0012.

Matthies HJ, Moore JL, Saunders C, Matthies DS, Lapierre LA, Goldenring JR, Blakely RD, Galli A. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. J. Neurosci. 2010 Jun 6/9/2010; 30(23): 7863-77. PMID: 20534835, PMCID: PMC2935280, PII: 30/23/7863, DOI: 10.1523/JNEUROSCI.4574-09.2010, ISSN: 1529-2401.

Goldenring JR, Nam KT, Wang TC, Mills JC, Wright NA. Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer [editorial]. Gastroenterology [print-electronic]. 2010 Jun; 138(7): 2207-10, 2210.e1. PMID: 20450866, PMCID: PMC3769643, PII: S0016-5085(10)00594-9, DOI: 10.1053/j.gastro.2010.04.023, ISSN: 1528-0012.

Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J. Clin. Invest [print-electronic]. 2010 Mar; 120(3): 840-9. PMID: 20197623, PMCID: PMC2827957, PII: 40728, DOI: 10.1172/JCI40728, ISSN: 1558-8238.

Goldenring JR. Perspective: Innocence and due diligence: managing unfounded allegations of scientific misconduct. Acad Med. 2010 Mar; 85(3): 527-30. PMID: 20182133, PII: 00001888-201003000-00034, DOI: 10.1097/ACM.0b013e3181cd4c7a, ISSN: 1938-808X.

Goldenring JR, Nam KT. Oxyntic atrophy, metaplasia, and gastric cancer. Prog Mol Biol Transl Sci. 2010; 96: 117-31. PMID: 21075342, PMCID: PMC4502917, PII: B978-0-12-381280-3.00005-1, DOI: 10.1016/B978-0-12-381280-3.00005-1, ISSN: 1878-0814.

Fiske WH, Tanksley J, Nam KT, Goldenring JR, Slebos RJ, Liebler DC, Abtahi AM, La Fleur B, Ayers GD, Lind CD, Washington MK, Coffey RJ. Efficacy of cetuximab in the treatment of Menetrier's disease. Sci Transl Med. 2009 Nov 11/25/2009; 1(8): 8ra18. PMID: 20368185, PMCID: PMC3638759, PII: 1/8/8ra18, DOI: 10.1126/scitranslmed.3000320, ISSN: 1946-6242.

Eggers CT, Schafer JC, Goldenring JR, Taylor SS. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J. Biol. Chem [print-electronic]. 2009 Nov 11/20/2009; 284(47): 32869-80. PMID: 19797056, PMCID: PMC2781703, PII: M109.022582, DOI: 10.1074/jbc.M109.022582, ISSN: 1083-351X.

Aikou S, Fukushima Y, Ogawa M, Nozaki K, Saito T, Matsui T, Goldenring JR, Kaminishi M, Nomura S. Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice. Dig. Dis. Sci [print-electronic]. 2009 Aug; 54(8): 1625-35. PMID: 19507031, DOI: 10.1007/s10620-009-0832-2, ISSN: 1573-2568.

Nozaki K, Weis V, Wang TC, Falus A, Goldenring JR. Altered gastric chief cell lineage differentiation in histamine-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2009 Jun; 296(6): G1211-20. PMID: 19359424, PMCID: PMC2697940, PII: 90643.2008, DOI: 10.1152/ajpgi.90643.2008, ISSN: 0193-1857.

Tzaban S, Massol RH, Yen E, Hamman W, Frank SR, Lapierre LA, Hansen SH, Goldenring JR, Blumberg RS, Lencer WI. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J. Cell Biol. 2009 May 5/18/2009; 185(4): 673-84. PMID: 19451275, PMCID: PMC2711563, PII: jcb.200809122, DOI: 10.1083/jcb.200809122, ISSN: 1540-8140.

Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR. Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology [print-electronic]. 2009 Apr; 136(4): 1288-96. PMID: 19230855, PMCID: PMC2844775, PII: S0016-5085(08)02261-0, DOI: 10.1053/j.gastro.2008.12.037, ISSN: 1528-0012.

Kolobova E, Efimov A, Kaverina I, Rishi AK, Schrader JW, Ham AJ, Larocca MC, Goldenring JR. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp. Cell Res [print-electronic]. 2009 Feb 2/1/2009; 315(3): 542-55. PMID: 19073175, PMCID: PMC2788823, PII: S0014-4827(08)00501-6, DOI: 10.1016/j.yexcr.2008.11.011, ISSN: 1090-2422.

Roland JT, Lapierre LA, Goldenring JR. Alternative splicing in class V myosins determines association with Rab10. J. Biol. Chem [print-electronic]. 2009 Jan 1/9/2009; 284(2): 1213-23. PMID: 19008234, PMCID: PMC2613619, PII: M805957200, DOI: 10.1074/jbc.M805957200, ISSN: 0021-9258.

Weis VG, Goldenring JR. Current understanding of SPEM and its standing in the preneoplastic process. Gastric Cancer [print-electronic]. 2009; 12(4): 189-97. PMID: 20047123, PMCID: PMC4502916, DOI: 10.1007/s10120-009-0527-6, ISSN: 1436-3291.

Schonteich E, Wilson GM, Burden J, Hopkins CR, Anderson K, Goldenring JR, Prekeris R. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J. Cell. Sci [print-electronic]. 2008 Nov 11/15/2008; 121(Pt 22): 3824-33. PMID: 18957512, PMCID: PMC4365997, PII: jcs.032441, DOI: 10.1242/jcs.032441, ISSN: 0021-9533.

Khandelwal P, Ruiz WG, Balestreire-Hawryluk E, Weisz OA, Goldenring JR, Apodaca G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Oct 10/14/2008; 105(41): 15773-8. PMID: 18843107, PMCID: PMC2572972, PII: 0805636105, DOI: 10.1073/pnas.0805636105, ISSN: 1091-6490.

Cao Z, Li C, Higginbotham JN, Franklin JL, Tabb DL, Graves-Deal R, Hill S, Cheek K, Jerome WG, Lapierre LA, Goldenring JR, Ham AJ, Coffey RJ. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol. Cell Proteomics [print-electronic]. 2008 Sep; 7(9): 1651-67. PMID: 18504258, PMCID: PMC2528074, PII: M700155-MCP200, DOI: 10.1074/mcp.M700155-MCP200, ISSN: 1535-9484.

Utley TJ, Ducharme NA, Varthakavi V, Shepherd BE, Santangelo PJ, Lindquist ME, Goldenring JR, Crowe JE. Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Jul 7/22/2008; 105(29): 10209-14. PMID: 18621683, PMCID: PMC2481327, PII: 0712144105, DOI: 10.1073/pnas.0712144105, ISSN: 1091-6490.

Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology [print-electronic]. 2008 Feb; 134(2): 511-22. PMID: 18242217, PMCID: PMC2857727, PII: S0016-5085(07)02156-7, DOI: 10.1053/j.gastro.2007.11.058, ISSN: 1528-0012.

Yoshizawa N, Takenaka Y, Yamaguchi H, Tetsuya T, Tanaka H, Tatematsu M, Nomura S, Goldenring JR, Kaminishi M. Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab. Invest. 2007 Dec; 87(12): 1265-76. PMID: 18004396, PII: 3700682, DOI: 10.1038/labinvest.3700682, ISSN: 1530-0307.

Oztan A, Silvis M, Weisz OA, Bradbury NA, Hsu SC, Goldenring JR, Yeaman C, Apodaca G. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol. Biol. Cell [print-electronic]. 2007 Oct; 18(10): 3978-92. PMID: 17686995, PMCID: PMC1995710, PII: E07-02-0097, DOI: 10.1091/mbc.E07-02-0097, ISSN: 1059-1524.

Ducharme NA, Williams JA, Oztan A, Apodaca G, Lapierre LA, Goldenring JR. Rab11-FIP2 regulates differentiable steps in transcytosis. Am. J. Physiol., Cell Physiol [print-electronic]. 2007 Sep; 293(3): C1059-72. PMID: 17626244, PII: 00078.2007, DOI: 10.1152/ajpcell.00078.2007, ISSN: 0363-6143.

Cresawn KO, Potter BA, Oztan A, Guerriero CJ, Ihrke G, Goldenring JR, Apodaca G, Weisz OA. Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J [print-electronic]. 2007 Aug 8/22/2007; 26(16): 3737-48. PMID: 17673908, PMCID: PMC1952228, PII: 7601813, DOI: 10.1038/sj.emboj.7601813, ISSN: 0261-4189.

Roland JT, Kenworthy AK, Peranen J, Caplan S, Goldenring JR. Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. Mol. Biol. Cell [print-electronic]. 2007 Aug; 18(8): 2828-37. PMID: 17507647, PMCID: PMC1949367, PII: E07-02-0169, DOI: 10.1091/mbc.E07-02-0169, ISSN: 1059-1524.

Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development [print-electronic]. 2007 Jul; 134(13): 2521-31. PMID: 17522155, PMCID: PMC3625644, PII: dev.003855, DOI: 10.1242/dev.003855, ISSN: 0950-1991.

Lapierre LA, Avant KM, Caldwell CM, Ham AJ, Hill S, Williams JA, Smolka AJ, Goldenring JR. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2007 May; 292(5): G1249-62. PMID: 17255364, PII: 00505.2006, DOI: 10.1152/ajpgi.00505.2006, ISSN: 0193-1857.

Nam KT, Varro A, Coffey RJ, Goldenring JR. Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology [print-electronic]. 2007 May; 132(5): 1804-19. PMID: 17484876, PII: S0016-5085(07)00564-1, DOI: 10.1053/j.gastro.2007.03.040, ISSN: 0016-5085.

Neel NF, Lapierre LA, Goldenring JR, Richmond A. RhoB plays an essential role in CXCR2 sorting decisions. J. Cell. Sci [print-electronic]. 2007 May 5/1/2007; 120(Pt 9): 1559-71. PMID: 17405813, PMCID: PMC2766565, PII: jcs.03437, DOI: 10.1242/jcs.03437, ISSN: 0021-9533.

Nedvetsky PI, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, Hammer JA, Nielsen S, Goldenring JR, Rosenthal W, Klussmann E. A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic [print-electronic]. 2007 Feb; 8(2): 110-23. PMID: 17156409, PII: TRA508, DOI: 10.1111/j.1600-0854.2006.00508.x, ISSN: 1398-9219.

Leys CM, Nomura S, LaFleur BJ, Ferrone S, Kaminishi M, Montgomery E, Goldenring JR. Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer. Surgery [print-electronic]. 2007 Jan; 141(1): 41-50. PMID: 17188166, PII: S0039-6060(06)00346-1, DOI: 10.1016/j.surg.2006.05.009, ISSN: 0039-6060.

Goldenring JR, Nomura S. Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Am. J. Physiol. Gastrointest. Liver Physiol. 2006 Dec; 291(6): G999-1004. PMID: 17090722, PII: 291/6/G999, DOI: 10.1152/ajpgi.00187.2006, ISSN: 0193-1857.

Lang MR, Lapierre LA, Frotscher M, Goldenring JR, Knapik EW. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat. Genet [print-electronic]. 2006 Oct; 38(10): 1198-203. PMID: 16980978, PII: ng1880, DOI: 10.1038/ng1880, ISSN: 1061-4036.

Leys CM, Nomura S, Rudzinski E, Kaminishi M, Montgomery E, Washington MK, Goldenring JR. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Hum. Pathol [print-electronic]. 2006 Sep; 37(9): 1162-8. PMID: 16938521, PII: S0046-8177(06)00219-X, DOI: 10.1016/j.humpath.2006.04.011, ISSN: 0046-8177.

Ducharme NA, Hales CM, Lapierre LA, Ham AJ, Oztan A, Apodaca G, Goldenring JR. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol. Biol. Cell [print-electronic]. 2006 Aug; 17(8): 3625-37. PMID: 16775013, PMCID: PMC1525241, PII: E05-08-0736, DOI: 10.1091/mbc.E05-08-0736, ISSN: 1059-1524.

Larocca MC, Jin M, Goldenring JR. AKAP350 modulates microtubule dynamics. Eur. J. Cell Biol [print-electronic]. 2006 Jul; 85(7): 611-9. PMID: 16356588, PII: S0171-9335(05)00193-7, DOI: 10.1016/j.ejcb.2005.10.008, ISSN: 0171-9335.

Pooley RD, Reddy S, Soukoulis V, Roland JT, Goldenring JR, Bader DM. CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25. Mol. Biol. Cell [print-electronic]. 2006 Jul; 17(7): 3176-86. PMID: 16672379, PMCID: PMC1483049, PII: E05-12-1127, DOI: 10.1091/mbc.E05-12-1127, ISSN: 1059-1524.

Jin M, Goldenring JR. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Biochim. Biophys. Acta [print-electronic]. 2006 Jun; 1759(6): 281-95. PMID: 16920206, PII: S0167-4781(06)00093-5, DOI: 10.1016/j.bbaexp.2006.06.001, ISSN: 0006-3002.

Ogawa M, Nomura S, Varro A, Wang TC, Goldenring JR. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2006 Apr; 290(4): G793-804. PMID: 16306133, PII: 00309.2005, DOI: 10.1152/ajpgi.00309.2005, ISSN: 0193-1857.

Welch DC, Wirth PS, Goldenring JR, Ness E, Jagasia M, Washington K. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation?. Am. J. Surg. Pathol. 2006 Apr; 30(4): 444-9. PMID: 16625089, PII: 00000478-200604000-00003, ISSN: 0147-5185.

Varthakavi V, Smith RM, Martin KL, Derdowski A, Lapierre LA, Goldenring JR, Spearman P. The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release. Traffic. 2006 Mar; 7(3): 298-307. PMID: 16497224, PII: TRA380, DOI: 10.1111/j.1600-0854.2005.00380.x, ISSN: 1398-9219.

Ogawa M, Nomura S, Car BD, Goldenring JR. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig. Dis. Sci. 2006 Mar; 51(3): 431-9. PMID: 16614949, DOI: 10.1007/s10620-006-3151-x, ISSN: 0163-2116.

Lisé MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-Husseini A. Involvement of myosin Vb in glutamate receptor trafficking. J. Biol. Chem [print-electronic]. 2006 Feb 2/10/2006; 281(6): 3669-78. PMID: 16338934, PII: M511725200, DOI: 10.1074/jbc.M511725200, ISSN: 0021-9258.

Robert ME, Washington MK, Lee JR, Goldenring JR, Bronner MP, Goldblum JR, Greenson JK, Haber MM, Hart JA, Lamps LW, Lauwers GY, Lewin D, Lazenby AJ, Montgomery E, Crawford JM. Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus. Am. J. Clin. Pathol. 2005 Oct; 124(4): 519-27. PMID: 16146818, PII: 7X4GAXT15H50B48P, DOI: 10.1309/7X4GAXT15H50B48P, ISSN: 0002-9173.

Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ, Goldenring JR. Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology. 2005 May; 128(5): 1292-305. PMID: 15887112, PII: S0016508505004038, ISSN: 0016-5085.

Greengauz-Roberts O, Stöppler H, Nomura S, Yamaguchi H, Goldenring JR, Podolsky RH, Lee JR, Dynan WS. Saturation labeling with cysteine-reactive cyanine fluorescent dyes provides increased sensitivity for protein expression profiling of laser-microdissected clinical specimens. Proteomics. 2005 May; 5(7): 1746-57. PMID: 15761955, DOI: 10.1002/pmic.200401068, ISSN: 1615-9853.

Nomura S, Yamaguchi H, Ogawa M, Wang TC, Lee JR, Goldenring JR. Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2005 Feb; 288(2): G362-75. PMID: 15647607, PII: 288/2/G362, DOI: 10.1152/ajpgi.00160.2004, ISSN: 0193-1857.

Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow-derived cells. Science. 2004 Nov 11/26/2004; 306(5701): 1568-71. PMID: 15567866, PII: 306/5701/1568, DOI: 10.1126/science.1099513, ISSN: 1095-9203.

Nomura S, Baxter T, Yamaguchi H, Leys C, Vartapetian AB, Fox JG, Lee JR, Wang TC, Goldenring JR. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology. 2004 Aug; 127(2): 582-94. PMID: 15300590, PII: S0016508504009217, ISSN: 0016-5085.

Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR. AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus. Mol. Biol. Cell [print-electronic]. 2004 Jun; 15(6): 2771-81. PMID: 15047863, PMCID: PMC420101, PII: E03-10-0757, DOI: 10.1091/mbc.E03-10-0757, ISSN: 1059-1524.

Fan GH, Lapierre LA, Goldenring JR, Sai J, Richmond A. Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Mol. Biol. Cell [print-electronic]. 2004 May; 15(5): 2456-69. PMID: 15004234, PMCID: PMC404037, PII: E03-09-0706, DOI: 10.1091/mbc.E03-09-0706, ISSN: 1059-1524.

Li Y, Wandinger-Ness A, Goldenring JR, Cover TL. Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Mol. Biol. Cell [print-electronic]. 2004 Apr; 15(4): 1946-59. PMID: 14742715, PMCID: PMC379289, PII: E03-08-0618, DOI: 10.1091/mbc.E03-08-0618, ISSN: 1059-1524.

Provance DW, Gourley CR, Silan CM, Cameron LC, Shokat KM, Goldenring JR, Shah K, Gillespie PG, Mercer JA. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Feb 2/17/2004; 101(7): 1868-73. PMID: 14766983, PMCID: PMC357019, PII: 0305895101, DOI: 10.1073/pnas.0305895101, ISSN: 0027-8424.

Smolka AJ, Goldenring JR, Gupta S, Hammond CE. Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC Gastroenterol. 2004 Feb 2/10/2004; 4: 4. PMID: 15028114, PMCID: PMC368434, PII: 1471-230X-4-4, DOI: 10.1186/1471-230X-4-4, ISSN: 1471-230X.

Nomura, S, Yamaguchi, H., Wang, T.C, Lee, J.R. and Goldenring, J.R.. Alterations in gastric mucosal lineages by acute oxyntic atrophy in wild type and gastrin deficient mice. Amer. J. Physiol. 2004; ((in press)).

Brock SC, Goldenring JR, Crowe JE. Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Dec 12/9/2003; 100(25): 15143-8. PMID: 14630951, PMCID: PMC299925, PII: 2434327100, DOI: 10.1073/pnas.2434327100, ISSN: 0027-8424.

Berryman MA, Goldenring JR. CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells. Cell Motil. Cytoskeleton. 2003 Nov; 56(3): 159-72. PMID: 14569596, DOI: 10.1002/cm.10141, ISSN: 0886-1544.

Lapierre LA, Dorn MC, Zimmerman CF, Navarre J, Burnette JO, Goldenring JR. Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Exp. Cell Res. 2003 Nov 11/1/2003; 290(2): 322-31. PMID: 14567990, PII: S0014482703003409, ISSN: 0014-4827.

Hobdy-Henderson KC, Hales CM, Lapierre LA, Cheney RE, Goldenring JR. Dynamics of the apical plasma membrane recycling system during cell division. Traffic. 2003 Oct; 4(10): 681-93. PMID: 12956871, PII: 124, ISSN: 1398-9219.

Lee JR, Baxter TM, Yamaguchi H, Wang TC, Goldenring JR, Anderson MG. Differential protein analysis of spasomolytic polypeptide expressing metaplasia using laser capture microdissection and two-dimensional difference gel electrophoresis. Appl. Immunohistochem. Mol. Morphol. 2003 Jun; 11(2): 188-93. PMID: 12778007, ISSN: 1541-2016.

Fan GH, Lapierre LA, Goldenring JR, Richmond A. Differential regulation of CXCR2 trafficking by Rab GTPases. Blood [print-electronic]. 2003 Mar 3/15/2003; 101(6): 2115-24. PMID: 12411301, PII: 2002-07-1965, DOI: 10.1182/blood-2002-07-1965, ISSN: 0006-4971.

Halldórsdóttir AM, Sigurdardóttrir M, Jónasson JG, Oddsdóttir M, Magnússon J, Lee JR, Goldenring JR. Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland. Dig. Dis. Sci. 2003 Mar; 48(3): 431-41. PMID: 12757153, ISSN: 0163-2116.

Hales CM, Vaerman JP, Goldenring JR. Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling. J. Biol. Chem [print-electronic]. 2002 Dec 12/27/2002; 277(52): 50415-21. PMID: 12393859, PII: M209270200, DOI: 10.1074/jbc.M209270200, ISSN: 0021-9258.

Volpicelli LA, Lah JJ, Fang G, Goldenring JR, Levey AI. Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. J. Neurosci. 2002 Nov 11/15/2002; 22(22): 9776-84. PMID: 12427833, PII: 22/22/9776, ISSN: 1529-2401.

Shanks RA, Steadman BT, Schmidt PH, Goldenring JR. AKAP350 at the Golgi apparatus. I. Identification of a distinct Golgi apparatus targeting motif in AKAP350. J. Biol. Chem [print-electronic]. 2002 Oct 10/25/2002; 277(43): 40967-72. PMID: 12163481, PII: M203307200, DOI: 10.1074/jbc.M203307200, ISSN: 0021-9258.

Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, Goldenring JR. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. J. Biol. Chem [print-electronic]. 2002 Oct 10/25/2002; 277(43): 40973-80. PMID: 12163479, PII: M112277200, DOI: 10.1074/jbc.M112277200, ISSN: 0021-9258.

Wang TC, Goldenring JR. Inflammation intersection: gp130 balances gut irritation and stomach cancer. Nature medicine. 2002 Oct; 8(10) Sect. 1080,2.

Steadman BT, Schmidt PH, Shanks RA, Lapierre LA, Goldenring JR. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J. Biol. Chem [print-electronic]. 2002 Aug 8/16/2002; 277(33): 30165-76. PMID: 12015314, PII: M201914200, DOI: 10.1074/jbc.M201914200, ISSN: 0021-9258.

Yamaguchi H, Goldenring JR, Kaminishi M, Lee JR. Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in rats. Lab. Invest. 2002 Aug; 82(8): 1045-52. PMID: 12177243, ISSN: 0023-6837.

Yamaguchi H, Goldenring JR, Kaminishi M, Lee JR. Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig. Dis. Sci. 2002 Mar; 47(3): 573-8. PMID: 11911345, ISSN: 0163-2116.

Yamaguchi, H., GOLDENRING, J.R., Kaminishi, M. and Lee, J.R. Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig. Dis. Sci. 2002; 47: 573-8.

Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR. Identification and characterization of a family of Rab11-interacting proteins. J. Biol. Chem [print-electronic]. 2001 Oct 10/19/2001; 276(42): 39067-75. PMID: 11495908, PII: M104831200, DOI: 10.1074/jbc.M104831200, ISSN: 0021-9258.

Wang E, Pennington JG, Goldenring JR, Hunziker W, Dunn KW. Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J. Cell. Sci. 2001 Sep; 114(Pt 18): 3309-21. PMID: 11591819, ISSN: 0021-9533.

Goldenring JM, Allred G. Post-rape care in hospital emergency rooms [letter]. Am J Public Health. 2001 Aug; 91(8): 1169-70. PMID: 11499090, PMCID: PMC1446730, ISSN: 0090-0036.

Goldenring JR. Pools of actin in polarized cells: some filaments are more stable than others. Focus on "Functionally distinct pools of actin in secretory cells" [editorial]. Am. J. Physiol., Cell Physiol. 2001 Aug; 281(2): C386-7. PMID: 11443037, ISSN: 0363-6143.

Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, Provance DW, Mercer JA, Bähler M, Goldenring JR. Myosin vb is associated with plasma membrane recycling systems. Mol. Biol. Cell. 2001 Jun; 12(6): 1843-57. PMID: 11408590, PMCID: PMC37346, ISSN: 1059-1524.

Goldenring JR, Aron LM, Lapierre LA, Navarre J, Casanova JE. Expression and properties of Rab25 in polarized Madin-Darby canine kidney cells. Meth. Enzymol. 2001; 329: 225-34. PMID: 11210538, PII: S0076-6879(01)29082-X, ISSN: 0076-6879.

Hales, C.M., Griner, R., Navarre, J., Dorn, M.C., Hardy, D., Kumar, R., Chan, E.K.L., Lapierre, L.A. and GOLDENRING, J.R. Identification and characterization of a family of Rab11 interacting proteins. J. Biol. Chem. 2001; 276: 39067-75.

Wang, E., Pennington, J.G., GOLDENRING, J.R., Hunziker, W. and Dunn, K.W. Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J. Cell Sci. 2001; 114: 3309-21.

Lapierre, L.A., Kumar, R., Hales, C.M., Navarre, J., Bhartur, S.G., Burnette, J.O., Provance, W., Jr., Mercer, J., Bahler, M. and GOLDENRING, J.R. Myosin Vb is associated with plasma membrane recycling systems. Mol. Biol. Cell. 2001; 12: 1843-57.

GOLDENRING, J.R., Aron, L.M., Lapierre, L.A., Navarre, J. and Casanova, J.E. Expression and properties of Rab25 in polarized Madin-Darby canine kidney cells. Meth. Enzymol. 2001; 329: 225-34.

Burdick JS, Chung E, Tanner G, Sun M, Paciga JE, Cheng JQ, Washington K, Goldenring JR, Coffey RJ. Treatment of Ménétrier's disease with a monoclonal antibody against the epidermal growth factor receptor. N. Engl. J. Med. 2000 Dec 12/7/2000; 343(23): 1697-701. PMID: 11106719, DOI: 10.1056/NEJM200012073432305, ISSN: 0028-4793.

Lee MP, Ravenel JD, Hu RJ, Lustig LR, Tomaselli G, Berger RD, Brandenburg SA, Litzi TJ, Bunton TE, Limb C, Francis H, Gorelikow M, Gu H, Washington K, Argani P, Goldenring JR, Coffey RJ, Feinberg AP. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J. Clin. Invest. 2000 Dec; 106(12): 1447-55. PMID: 11120752, PMCID: PMC387258, DOI: 10.1172/JCI10897, ISSN: 0021-9738.

Wang X, Kumar R, Navarre J, Casanova JE, Goldenring JR. Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25. J. Biol. Chem. 2000 Sep 9/15/2000; 275(37): 29138-46. PMID: 10869360, PII: M004410200, DOI: 10.1074/jbc.M004410200, ISSN: 0021-9258.

Goldenring JR, Ray GS, Coffey RJ, Meunier PC, Haley PJ, Barnes TB, Car BD. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology. 2000 Jun; 118(6): 1080-93. PMID: 10833483, PII: S0016508500251962, ISSN: 0016-5085.

Bhartur SG, Calhoun BC, Woodrum J, Kurkjian J, Iyer S, Lai F, Goldenring JR. Genomic structure of murine Rab11 family members. Biochem. Biophys. Res. Commun. 2000 Mar 3/16/2000; 269(2): 611-7. PMID: 10708602, PII: S0006-291X(00)92334-9, DOI: 10.1006/bbrc.2000.2334, ISSN: 0006-291X.

Wang TC, Dangler CA, Chen D, Goldenring JR, Koh T, Raychowdhury R, Coffey RJ, Ito S, Varro A, Dockray GJ, Fox JG. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology. 2000 Jan; 118(1): 36-47. PMID: 10611152, PII: S0016508500790391, ISSN: 0016-5085.

Lee, M.P., Ravenal, J.D., Hu, R., Lustig, L.R., Tomaeli, G., Brandenburg, S.A., Litzi, T.J., Bunton, T.E., Limb, C., Francis, H., Gorelikow, M., Gu, H., Washington, K., Argani, P., GOLDENRING, J.R., Coffey, R.J., and Feinberg, A.P. Targeted disruption of the Kvlqt1 gene cause deafness and gastric hyperplasia in mice. J. Clin. Invest. 2000; 106: 1447-55.

Burdick, J.S., Chung, E., Lindberg, G., Tanner, G., Washington, K., GOLDENRING, J.R and Coffey, R.J. Treatament of Menetrier¿s disease with a monoclonal antibody against epidermal growth factor receptor. New Eng. J. Med. 2000; 343: 1697-701.

Wang, X., Kumar, R., Navarre, J., Casanova, J.E. and GOLDENRING, J.R. Regulation of membrane trafficking in MDCK cells by Rab11a and Rab25. J. Biol. Chem. 2000; 275: 29138-46.

Wang, T.C., Dangler, C.A., Chen, D., GOLDENRING, J.R., Koh, T., Raychowdhury, R., Coffey, R.J., Ito, S., Varro, A., Cockray, G.J. and Fox, J.G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a gastric cancer mouse model. Gastroenterology. 2000; 118: 36-47.

Bhartur, S.G., Calhoun, B.C., Woodrum, J., Kurkjian, J., Iyer, S., Lai, F. and GOLDENRING, J.R. Genomic structure of murine Rab11 family members. Biochem. Biophys. Res. Commun. 2000; 269: 611-7.

GOLDENRING, J.R., Ray, G .S., Coffey, R.J., Jr., Meunier, P., Haley, P., Barnes, T.B., Car, B.D. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology. 2000; 118: 1080-93.

Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology. 1999 Dec; 117(6): 1416-26. PMID: 10579983, PII: S0016508599005648, ISSN: 0016-5085.

Lapierre LA, Tuma PL, Navarre J, Goldenring JR, Anderson JM. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. J. Cell. Sci. 1999 Nov; 112 ( Pt 21): 3723-32. PMID: 10523508, ISSN: 0021-9533.

Schmidt PH, Lee JR, Joshi V, Playford RJ, Poulsom R, Wright NA, Goldenring JR. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab. Invest. 1999 Jun; 79(6): 639-46. PMID: 10378506, ISSN: 0023-6837.

Goldenring JR, Ray GS, Lee JR. Rab11 in dysplasia of Barrett's epithelia. Yale J Biol Med. 1999 Mar; 72(2-3): 113-20. PMID: 10780572, PMCID: PMC2579020, ISSN: 0044-0086.

Schmidt PH, Dransfield DT, Claudio JO, Hawley RG, Trotter KW, Milgram SL, Goldenring JR. AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. J. Biol. Chem. 1999 Jan 1/29/1999; 274(5): 3055-66. PMID: 9915845, ISSN: 0021-9258.

Casanova JE, Wang X, Kumar R, Bhartur SG, Navarre J, Woodrum JE, Altschuler Y, Ray GS, Goldenring JR. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol. Biol. Cell. 1999 Jan; 10(1): 47-61. PMID: 9880326, PMCID: PMC25153, ISSN: 1059-1524.

Schmidt, P.H., Dransfield, D.T., Claudio, J.T., Hawley, R.G., Trotter, K.W., Milgram, S.L. and GOLDENRING, J.R. AKAP350: A multiply spliced A-kinase anchoring protein associated with centrosomes. J. Biol. Chem. 1999; 274: 3055-66.

Song, S.Y., Gannon, M., Washington, M.K., Scogins, C.R., Meszoely, I.M., GOLDENRING, J.R., Marino, C.R., Sandgren, E.P., Coffey, R.J., Jr., Wright, C.V.E. and Leach, S.D. Expansion of pdx1-expressing pancreatic epithelium and initiation of islet neogenesis in transgenic mice overexpressing TGF. Gastroenterology. 1999; 117: 1416-26.

Casanova, J.E., Wang, X., Kumar, R., Bhartur, S.G., Navarre, J., Woodrum, J.E., Ray, G.S. and GOLDENRING, J.R. Rab11a and Rab25 association with the apical recycling system of polarized MDCK cells. Mol. Biol. Cell. 1999; 10: 47-61.

Schmidt, P.H., Lee, J.R., Joshi, V., Playford, R.J., Poulsom, R., Wright, N.A. and GOLDENRING, J.R. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab. Invest. 1999; 79: 639-46.

Calhoun BC, Lapierre LA, Chew CS, Goldenring JR. Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells. Am. J. Physiol. 1998 Jul; 275(1 Pt 1): C163-70. PMID: 9688847, ISSN: 0002-9513.

Majumdar AP, Goldenring JR. Localization and significance of pp55, a gastric mucosal membrane protein with tyrosine kinase activity. Am. J. Physiol. 1998 May; 274(5 Pt 1): G863-70. PMID: 9612267, ISSN: 0002-9513.

Okamoto CT, Karam SM, Jeng YY, Forte JG, Goldenring JR. Identification of clathrin and clathrin adaptors on tubulovesicles of gastric acid secretory (oxyntic) cells. Am. J. Physiol. 1998 Apr; 274(4 Pt 1): C1017-29. PMID: 9575799, ISSN: 0002-9513.

Wang TC, Goldenring JR, Dangler C, Ito S, Mueller A, Jeon WK, Koh TJ, Fox JG. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology. 1998 Apr; 114(4): 675-89. PMID: 9516388, PII: S0016508598003266, ISSN: 0016-5085.

Bhartur SG, Goldenring JR. Mapping of ezrin dimerization using yeast two-hybrid screening. Biochem. Biophys. Res. Commun. 1998 Feb 2/24/1998; 243(3): 874-7. PMID: 9501018, PII: S0006-291X(98)98196-7, DOI: 10.1006/bbrc.1998.8196, ISSN: 0006-291X.

Wang, T.C., GOLDENRING, J.R., Dangler, C., Millar, A., Jeon, W.K., Ito, S., Koh, T.J. and Fox, J.G. C57BL/6 mice deficient in secretory phospholipase A2 show increased apoptosis and altered cellular differentiation during Helicobacter felis infection. Gastroenterology. 1998; 114: 675-89.

Calhoun, B.C. and GOLDENRING, J.R. Rab11 redistributes to the apical secretory canaliculus during stimulation of gastric parietal cells. Amer. J. Physiol. 1998; 275: C163-C170.

Okamoto, C. T., Karam, S. M., Jeng, Y. Y., Forte, J.G. and GOLDENRING, J.R. Identification of a clathrin adapter (AP-1)-related complex on tubulovesicles of gastric acid secretory (oxyntic) cells. Am. J. Physiol. 1998; 274: C1017-C1029.

Ray GS, Lee JR, Nwokeji K, Mills LR, Goldenring JR. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. Lab. Invest. 1997 Nov; 77(5): 503-11. PMID: 9389793, ISSN: 0023-6837.

Green EG, Ramm E, Riley NM, Spiro DJ, Goldenring JR, Wessling-Resnick M. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem. Biophys. Res. Commun. 1997 Oct 10/20/1997; 239(2): 612-6. PMID: 9344879, PII: S0006-291X(97)97520-3, DOI: 10.1006/bbrc.1997.7520, ISSN: 0006-291X.

Koh TJ, Goldenring JR, Ito S, Mashimo H, Kopin AS, Varro A, Dockray GJ, Wang TC. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology. 1997 Sep; 113(3): 1015-25. PMID: 9287997, PII: S0016508597004423, ISSN: 0016-5085.

Calhoun BC, Goldenring JR. Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles. Biochem. J. 1997 Jul 7/15/1997; 325 ( Pt 2): 559-64. PMID: 9230141, PMCID: PMC1218595, ISSN: 0264-6021.

Joshi V, Ray GS, Goldenring JR. Inhibition of parietal cell acid secretion is mediated by the classical epidermal growth factor receptor. Dig. Dis. Sci. 1997 Jun; 42(6): 1194-8. PMID: 9201084, ISSN: 0163-2116.

Beall AC, Kato K, Goldenring JR, Rasmussen H, Brophy CM. Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein. J. Biol. Chem. 1997 Apr 4/25/1997; 272(17): 11283-7. PMID: 9111032, ISSN: 0021-9258.

Dransfield DT, Yeh JL, Bradford AJ, Goldenring JR. Identification and characterization of a novel A-kinase-anchoring protein (AKAP120) from rabbit gastric parietal cells. Biochem. J. 1997 Mar 3/15/1997; 322 ( Pt 3): 801-8. PMID: 9148752, PMCID: PMC1218258, ISSN: 0264-6021.

Dransfield DT, Bradford AJ, Smith J, Martin M, Roy C, Mangeat PH, Goldenring JR. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J. 1997 Jan 1/2/1997; 16(1): 35-43. PMID: 9009265, PMCID: PMC1169611, DOI: 10.1093/emboj/16.1.35, ISSN: 0261-4189.

Dransfield, D.T., Bradford, A.J., Martin, M., Mangeat, P.H. and GOLDENRING, J.R. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein (AKAP). EMBO J. 1997; 16: 35-43.

Green, E.G., Ramm, E., Riley, N.M., Spiro, D.J., Goldenring, J.R. and Wessling-Resnick, M. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem. Biophys. Res. Commun. 1997; 239: 612-7.

Calhoun, B.C. and GOLDENRING, J.R. Two rab proteins, VAMP-2 and SCAMPs are present on immunoisolated parietal cell tubulovesicles. Biochem. J. 1997; 325: 559-64.

Ray, G.S., Lee, J., Nwokeji, K., Mills, L. and GOLDENRING, J.R. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low grade dysplasic Barrett¿s epithelia. Lab. Invest. 1997; 77: 503-11.

Dransfield, D.T., Bradford, A.J., Yeh, J., and GOLDENRING, J.R. Identification and characterization of a novel A-kinase anchoring protein (AKAP120). Biochem J. 1997; 322: 801-7.

Navarre J, Bradford AJ, Calhoun BC, Goldenring JR. Quenching of endogenous peroxidase in western blot. BioTechniques. 1996 Dec; 21(6): 990-2. PMID: 8969819, ISSN: 0736-6205.

Matovcik LM, Maranto AR, Soroka CJ, Gorelick FS, Smith J, Goldenring JR. Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. J. Histochem. Cytochem. 1996 Nov; 44(11): 1243-50. PMID: 8918899, ISSN: 0022-1554.

Ray GS, Jackson MW, Goldenring JR. Foveolar hyperplasia following partial gastrectomy results from expansion of surface mucous cell compartment. Dig. Dis. Sci. 1996 Oct; 41(10): 2016-24. PMID: 8888716, ISSN: 0163-2116.

Parente JA, Goldenring JR, Petropoulos AC, Hellman U, Chew CS. Purification, cloning, and expression of a novel, endogenous, calcium-sensitive, 28-kDa phosphoprotein. J. Biol. Chem. 1996 Aug 8/16/1996; 271(33): 20096-101. PMID: 8702730, ISSN: 0021-9258.

Sheehan D, Ray GS, Calhoun BC, Goldenring JR. A somatodendritic distribution of Rab11 in rabbit brain neurons. Neuroreport. 1996 May 5/17/1996; 7(7): 1297-300. PMID: 8817553, ISSN: 0959-4965.

Goldenring JR, Ray GS, Soroka CJ, Smith J, Modlin IM, Meise KS, Coffey RJ. Overexpression of transforming growth factor-alpha alters differentiation of gastric cell lineages. Dig. Dis. Sci. 1996 Apr; 41(4): 773-84. PMID: 8674399, ISSN: 0163-2116.

Canfield V, West AB, Goldenring JR, Levenson R. Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. Proc. Natl. Acad. Sci. U.S.A. 1996 Mar 3/19/1996; 93(6): 2431-5. PMID: 8637891, PMCID: PMC39814, ISSN: 0027-8424.

Goldenring JR, Smith J, Vaughan HD, Cameron P, Hawkins W, Navarre J. Rab11 is an apically located small GTP-binding protein in epithelial tissues. Am. J. Physiol. 1996 Mar; 270(3 Pt 1): G515-25. PMID: 8638719, ISSN: 0002-9513.

Modlin IM, Zhu Z, Tang LH, Kidd M, Lawton GP, Miu K, Powers RE, Goldenring JR, Pasikhov D, Soroka CJ. Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia. Digestion. 1996; 57(5): 310-21. PMID: 8886574, ISSN: 0012-2823.

Calhoun BC, Goldenring JR. Rab proteins in gastric parietal cells: evidence for the membrane recycling hypothesis. Yale J Biol Med. 1996 Jan; 69(1): 1-8. PMID: 9041684, PMCID: PMC2588980, ISSN: 0044-0086.

Goldenring JR, Poulsom R, Ray GS, Wright N, Meise KS, Coffey RJ. Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha. Growth Factors. 1996; 13(1-2): 111-9. PMID: 8962716, ISSN: 0897-7194.

GOLDENRING, J.R., Smith, J., Vaughan, H.D., Cameron, P., Hawkins, W. and Navarre, J. Rab11 is an apically located small GTP-binding protein in epithelial tissues. Amer. J. Physiol. 1996; 270: G515-G525.

Parente, J.A., GOLDENRING, J.R., Petropoulos, A.C., Hellman, U. and Chew, C.S. Purification, cloning and expression of a novel endogenous, calcium-sensitive, 28 kDa phosphoprotein. J. Biol. Chem. 1996; 271: 20096-101.

GOLDENRING, J.R., Ray, G.S., Soroka, C.J., Smith, J., Modlin, I.M., Meise, K.S. and Coffey, R.J., Jr. Over-expression of transforming growth factor-alpha alters the differentiation of gastric cell lineages. Dig. Dis. Sci. 1996; 41: 773-84.

Dransfield DT, Bradford AJ, Goldenring JR. Distribution of A-kinase anchoring proteins in parietal cells. Biochim. Biophys. Acta. 1995 Nov 11/30/1995; 1269(3): 215-20. PMID: 7495873, ISSN: 0006-3002.

Tang LH, Modlin IM, Caulfield TA, Goldenring JR. A novel serine-specific kinase activity associated with exocrine secretory granules. Am. J. Physiol. 1995 Oct; 269(4 Pt 1): G481-9. PMID: 7485499, ISSN: 0002-9513.

Quin JA, Sgambati SA, Goldenring JR, Basson MD, Fielding LP, Modlin IM, Ballantyne GH. PYY inhibition of VIP-stimulated ion transport in the rabbit distal ileum. J. Surg. Res. 1995 Jan; 58(1): 111-5. PMID: 7830399, PII: S0022-4804(85)71018-9, DOI: 10.1006/jsre.1995.1018, ISSN: 0022-4804.

Bergh CM, Brophy CM, Dransfield DT, Lincoln T, Goldenring JR, Rasmussen H. Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle. Am. J. Physiol. 1995 Jan; 268(1 Pt 2): H202-12. PMID: 7530917, ISSN: 0002-9513.

Goldenring JR, Soroka CJ, Shen KR, Tang LH, Rodriguez W, Vaughan HD, Stoch SA, Modlin IM. Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells. Am. J. Physiol. 1994 Aug; 267(2 Pt 1): G187-94. PMID: 8074219, ISSN: 0002-9513.

Modlin IM, Kumar RR, Soroka CJ, Ahlman H, Nilsson O, Goldenring JR. Histamine as an intermediate growth factor in genesis of gastric ECLomas associated with hypergastrinemia in mastomys. Dig. Dis. Sci. 1994 Jul; 39(7): 1446-53. PMID: 8026255, ISSN: 0163-2116.

Modlin IM, Goldenring JR, Lawton GP, Hunt R. Aspects of the theoretical basis and clinical relevance of low acid states. Am. J. Gastroenterol. 1994 Mar; 89(3): 308-18. PMID: 8122637, ISSN: 0002-9270.

GOLDENRING, J.R., Soroka, C.J., Shen, R.K., Tang, L.H., Rodriguez, W., Vaughan, J.D., Stoche, S.A. and Modlin, I.M. Enrichment of rab11, a low molecular weight GTPase, in gastric parietal cells. Amer. J. Physiol. 1994; 267: G187-G194.

Tang LH, Miller MD, Goldenring JR, Modlin IM, Hersey SJ. Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion. Am. J. Physiol. 1993 Nov; 265(5 Pt 1): G865-72. PMID: 8238515, ISSN: 0002-9513.

Chough SP, Goldenring JR, Hurst RD, Ballantyne GH, Modlin IM. Calcium modulation of the effects of serotonin, carbachol, and histamine on rabbit ileal ion transport. Yale J Biol Med. 1993 Nov; 66(6): 525-40. PMID: 7716972, PMCID: PMC2588855, ISSN: 0044-0086.

Mamiya N, Goldenring JR, Tsunoda Y, Modlin IM, Yasui K, Usuda N, Ishikawa T, Natsume A, Hidaka H. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93. Biochem. Biophys. Res. Commun. 1993 Sep 9/15/1993; 195(2): 608-15. PMID: 7690557, PII: S0006-291X(83)72089-9, DOI: 10.1006/bbrc.1993.2089, ISSN: 0006-291X.

Goldenring JR, Shen KR, Vaughan HD, Modlin IM. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J. Biol. Chem. 1993 Sep 9/5/1993; 268(25): 18419-22. PMID: 8360141, ISSN: 0021-9258.

Ballantyne GH, Goldenring JR, Savoca PE, Kranz HK, Adrian TE, Bilchik AJ, Modlin IM. Cyclic AMP-mediated release of peptide YY (PYY) from the isolated perfused rabbit distal colon. Regul. Pept. 1993 Sep 9/3/1993; 47(2): 117-26. PMID: 7694325, ISSN: 0167-0115.

Ballantyne GH, Goldenring JR, Fleming FX, Rush S, Flint JS, Fielding LP, Binder HJ, Modlin IM. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. Am. J. Physiol. 1993 May; 264(5 Pt 1): G848-54. PMID: 8388641, ISSN: 0002-9513.

Matovcik LM, Haimowitz B, Goldenring JR, Czernik AJ, Gorelick FS. Distribution of calcium/calmodulin-dependent protein kinase II in rat ileal enterocytes. Am. J. Physiol. 1993 Apr; 264(4 Pt 1): C1029-36. PMID: 8386447, ISSN: 0002-9513.

Soroka CJ, Chew CS, Hanzel DK, Smolka A, Modlin IM, Goldenring JR. Characterization of membrane and cytoskeletal compartments in cultured parietal cells: immunofluorescence and confocal microscopic examination. Eur. J. Cell Biol. 1993 Feb; 60(1): 76-87. PMID: 8385019, ISSN: 0171-9335.

Tsunoda Y, Modlin IM, Goldenring JR. Tyrosine kinase activities in the modulation of stimulated parietal cell acid secretion. Am. J. Physiol. 1993 Feb; 264(2 Pt 1): G351-6. PMID: 8383442, ISSN: 0002-9513.

Goldenring JR, Tsunoda Y, Stoch SA, Coffey RJ, Modlin IM. Transforming growth factor-alpha (TGF alpha) inhibition of parietal cell secretion: structural requirements for activity. Regul. Pept. 1993 Jan 1/22/1993; 43(1-2): 37-47. PMID: 8426908, ISSN: 0167-0115.

Tsunoda, Y., Modlin, I.M. and GOLDENRING, J.R. Tyrosine kinase activities in the modulation of stimulated parietal cell secretion. Am. J. Physiol. 1993; 264: G351-G356.

Soroka, C.J., Chew, C.S., Modlin, I.M., Hanzel, D., Smolka, A. and GOLDENRING, J.R. Characterization of membrane and cytoskeletal compartments in cultured parietal cells using immunofluoresence and confocal microscopy. Eur. J. Cell Biol. 1993; 60: 76-87.

GOLDENRING, J.R., Shen, R.K., Vaughan, H.D. and Modlin, I.M. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney and lung. J. Biol. Chem. 1993; 268: 18419-22.

Dempsey PJ, Goldenring JR, Soroka CJ, Modlin IM, McClure RW, Lind CD, Ahlquist DA, Pittelkow MR, Lee DC, Sandgren EP. Possible role of transforming growth factor alpha in the pathogenesis of Ménétrier's disease: supportive evidence form humans and transgenic mice. Gastroenterology. 1992 Dec; 103(6): 1950-63. PMID: 1451986, PII: S0016508592004931, ISSN: 0016-5085.

Modlin IM, Kumar R, Nangia A, Soroka CJ, Pasikhov D, Goldenring JR. Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas. Surgery. 1992 Dec; 112(6): 1048-56; discussion 1056. PMID: 1360710, PII: 0039-6060(92)90307-L, ISSN: 0039-6060.

Goldenring JR, Tang LH, Modlin IM. Small GTP-binding proteins in parietal cells: candidate modulators of parietal cell membrane dynamics. Yale J Biol Med. 1992 Nov; 65(6): 597-605. PMID: 1341066, PMCID: PMC2589774, ISSN: 0044-0086.

Funasaka M, Fox LM, Tang LH, Modlin IM, Goldenring JR. The major calmodulin-binding protein in rabbit parietal cells is Ca2+/calmodulin-dependent protein kinase II. Biochem. Int. 1992 Sep; 27(6): 1101-9. PMID: 1332720, ISSN: 0158-5231.

Tang LH, Stoch SA, Modlin IM, Goldenring JR. Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells. Biochem. J. 1992 Aug 8/1/1992; 285 ( Pt 3): 715-9. PMID: 1323270, PMCID: PMC1132853, ISSN: 0264-6021.

Reubi JC, Waser B, Horisberger U, Halter F, Soroka CJ, Kumar RR, Goldenring JR, Modlin IM. Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors. Endocrinology. 1992 Jul; 131(1): 166-72. PMID: 1319317, DOI: 10.1210/endo.131.1.1319317, ISSN: 0013-7227.

Goldenring JR, Asher VA, Barreuther MF, Lewis JJ, Lohmann SM, Walter U, Modlin IM. Dephosphorylation of cAMP-dependent protein kinase regulatory subunit in stimulated parietal cells. Am. J. Physiol. 1992 Apr; 262(4 Pt 1): G763-73. PMID: 1314500, ISSN: 0002-9513.

Tsunoda Y, Funasaka M, Modlin IM, Hidaka H, Fox LM, Goldenring JR. An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion. Am. J. Physiol. 1992 Jan; 262(1 Pt 1): G118-22. PMID: 1310221, ISSN: 0002-9513.

GOLDENRING, J.R., Asher, V.A., Barreuther, M.F., Lewis, J.J., Lohmann, S., Walter, U. and Modlin, I.M. Stimulation of isolated gastric parietal cells activates dephosphorylation of membrane-bound Type II regulatory subunit of cyclic AMP-dependent protein kinase. Am. J. Physiol. 1992; 279: 763-73.

Tang, L.H., Stoch, S.A., Modlin, I.M. and GOLDENRING, J.R. Identification of rab2 as a tubulovesicle-membrane associated protein in rabbit parietal cells. Biochem. J. 1992; 285: 715-9.

Basson MD, Goldenring JR, Tang LH, Lewis JJ, Padfield P, Jamieson JD, Modlin IM. Redistribution of 23 kDa tubulovesicle-associated GTP-binding proteins during parietal cell stimulation. Biochem. J. 1991 Oct 10/1/1991; 279 ( Pt 1): 43-8. PMID: 1656941, PMCID: PMC1151544, ISSN: 0264-6021.

Nilsson O, Bilchik AJ, Goldenring JR, Ballantyne GH, Adrian TE, Modlin IM. Distribution and immunocytochemical colocalization of peptide YY and enteroglucagon in endocrine cells of the rabbit colon. Endocrinology. 1991 Jul; 129(1): 139-48. PMID: 1675986, DOI: 10.1210/endo-129-1-139, ISSN: 0013-7227.

Modlin IM, Esterline W, Kim H, Goldenring JR. Enterochromaffin-like cells and gastric argyrophil carcinoidosis. Acta Oncol. 1991; 30(4): 493-8. PMID: 1854506, ISSN: 0284-186X.

Basson, M.D., GOLDENRING, J.R., Tang, L.H., Lewis, J.J., Padfield, P., Jamieson, J.J. and Modlin, I.M. Movement of a 23 kDa tubulovesicle-associated GTP-binding protein during parietal cell stimulation. Biochem. J. 1991; 279: 43-8.

Flint JS, Ballantyne GH, Goldenring JR, Fielding LP, Modlin IM. Neuropeptide Y inhibition of vasoactive intestinal polypeptide-stimulated ion transport in the rabbit distal colon. Arch Surg. 1990 Dec; 125(12): 1561-3. PMID: 2173897, ISSN: 0004-0010.

Lewis JJ, Goldenring JR, Modlin IM, Coffey RJ. Inhibition of parietal cell H+ secretion by transforming growth factor alpha: a possible autocrine regulatory mechanism. Surgery. 1990 Aug; 108(2): 220-6; discussion 226. PMID: 2382222, ISSN: 0039-6060.

Lewis JJ, Goldenring JR, Asher VA, Modlin IM. Effects of epidermal growth factor on signal transduction in rabbit parietal cells. Am. J. Physiol. 1990 Mar; 258(3 Pt 1): G476-83. PMID: 2156444, ISSN: 0002-9513.

Lewis, J.J., GOLDENRING, J.R., Asher, V.A. and Modlin, I.M. The effects of epidermal growth factor (EGF) on signal transduction in the rabbit parietal cell. Amer. J. Physiol. 1990; 258.

Adrian TE, Goldenring JR, Oddsdottir M, Zdon MJ, Zucker KA, Lewis JJ, Modlin IM. A micromethod for the assay of cellular secretory physiology: application to rabbit parietal cells. Anal. Biochem. 1989 Nov 11/1/1989; 182(2): 346-52. PMID: 2558591, ISSN: 0003-2697.

Lewis JJ, Goldenring JR, Asher VA, Modlin IM. Pancreastatin: a novel peptide inhibitor of parietal cell signal transduction. Biochem. Biophys. Res. Commun. 1989 Sep 9/15/1989; 163(2): 667-73. PMID: 2551271, PII: 0006-291X(89)92275-4, ISSN: 0006-291X.

Goldenring JR, Cahow CE. Intrahepatic cholangiojejunostomy as a palliative procedure in primary sclerosing cholangitis. Arch Surg. 1989 May; 124(5): 565-7. PMID: 2469409, ISSN: 0004-0010.

Adrian, T.E., GOLDENRING, J.R., Oddsdottir, M., Zdon, M.J., Zucker, K.A., Lewis, J.J., Modlin, I. M. A micromethod for the assay of cellular secretory physiology: Application to rabbit parietal cells. Anal. Biochem. 1989; 182: 346-52.

Oddsdottir M, Goldenring JR, Adrian TE, Zdon MJ, Zucker KA, Modlin IM. Identification and characterization of a cytosolic 30 kDa histamine stimulated phosphoprotein in parietal cell cytosol. Biochem. Biophys. Res. Commun. 1988 Jul 7/29/1988; 154(2): 489-96. PMID: 2840899, PII: 0006-291X(88)90166-0, ISSN: 0006-291X.

Oddsdottir M, Modlin IM, Zucker KA, Zdon MJ, Goldenring JR. A calmodulin dependent protein kinase in parietal cells. Biochem. Biophys. Res. Commun. 1987 Nov 11/13/1987; 148(3): 1390-7. PMID: 3689401, PII: S0006-291X(87)80286-3, ISSN: 0006-291X.

Modlin IM, Oddsdottir M, Adrian TE, Zdon MJ, Zucker KA, Goldenring JR. A specific histamine-stimulated phosphoprotein in isolated parietal cells. J. Surg. Res. 1987 Apr; 42(4): 348-53. PMID: 3033399, ISSN: 0022-4804.

Kreutter D, Kim JY, Goldenring JR, Rasmussen H, Ukomadu C, DeLorenzo RJ, Yu RK. Regulation of protein kinase C activity by gangliosides. J. Biol. Chem. 1987 Feb 2/5/1987; 262(4): 1633-7. PMID: 2433284, ISSN: 0021-9258.

Goldenring JR, Oddsdottir M, Modlin IM. A novel protein kinase activity in rabbit gastric gland cytosol. Biochem. Biophys. Res. Commun. 1987 Jan 1/30/1987; 142(2): 559-66. PMID: 3814150, PII: 0006-291X(87)90310-X, ISSN: 0006-291X.

Taft WC, Goldenring JR, DeLorenzo RJ. Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity. Adv. Exp. Med. Biol. 1987; 221: 409-25. PMID: 2829586, ISSN: 0065-2598.

Goldenring JR, Modlin IM, Tyshkov M, Zdon MJ, Schafer DE, Ballantyne GH. A manganese-dependent protein kinase in gastric gland cytosol. Surgery. 1986 Aug; 100(2): 181-7. PMID: 3738750, ISSN: 0039-6060.

Sakakibara M, Alkon DL, DeLorenzo R, Goldenring JR, Neary JT, Heldman E. Modulation of calcium-mediated inactivation of ionic currents by Ca2+/calmodulin-dependent protein kinase II. Biophys. J. 1986 Aug; 50(2): 319-27. PMID: 2427133, PMCID: PMC1329748, PII: S0006-3495(86)83465-8, DOI: 10.1016/S0006-3495(86)83465-8, ISSN: 0006-3495.

Goldenring JR, Wasterlain CG, Oestreicher AB, de Graan PN, Farber DB, Glaser G, DeLorenzo RJ. Kindling induces a long-lasting change in the activity of a hippocampal membrane calmodulin-dependent protein kinase system. Brain Res. 1986 Jul 7/2/1986; 377(1): 47-53. PMID: 3730855, ISSN: 0006-8993.

Goldenring JR, Lasher RS, Vallano ML, Ueda T, Naito S, Sternberger NH, Sternberger LA, DeLorenzo RJ. Association of synapsin I with neuronal cytoskeleton. Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J. Biol. Chem. 1986 Jun 6/25/1986; 261(18): 8495-504. PMID: 3087974, ISSN: 0021-9258.

Vallano ML, Goldenring JR, Lasher RS, Delorenzo RJ. Association of calcium/calmodulin-dependent kinase with cytoskeletal preparations: phosphorylation of tubulin, neurofilament, and microtubule-associated proteins. Ann. N. Y. Acad. Sci. 1986; 466: 357-74. PMID: 3089108, ISSN: 0077-8923.

Goldenring JR, DeLorenzo RJ. Phosphorylation of MAP-2 at distinct sites by calmodulin- and cyclic AMP-dependent kinases. Ann. N. Y. Acad. Sci. 1986; 466: 457-9. PMID: 3014968, ISSN: 0077-8923.

Goldenring JR, Vallano ML, Lasher RS, Ueda T, DeLorenzo RJ. Association of calmodulin-dependent kinase II and its substrate proteins with neuronal cytoskeleton. Prog. Brain Res. 1986; 69: 341-54. PMID: 2833804, ISSN: 0079-6123.

Kim JY, Goldenring JR, DeLorenzo RJ, Yu RK. Gangliosides inhibit phospholipid-sensitive Ca2+-dependent kinase phosphorylation of rat myelin basic proteins. J. Neurosci. Res. 1986; 15(2): 159-66. PMID: 2421006, DOI: 10.1002/jnr.490150205, ISSN: 0360-4012.

GOLDENRING, J.R., Lasher, R.S., Vallano, M.L., Udea, T., Naito, S., Sternberger, N.H., Sternberger, L.A. and DeLorenzo, R.J. Association of synapsin I with neuronal cytoskeleton: Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J. Biol. Chem. 1986; 261: 8495 8504.

Goldenring JR, Vallano ML, DeLorenzo RJ. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J. Neurochem. 1985 Sep; 45(3): 900-5. PMID: 2993517, ISSN: 0022-3042.

Billingsley ML, Velletri PA, Lovenberg W, Kuhn D, Goldenring JR, DeLorenzo RJ. Is Ca2+-calmodulin-dependent protein phosphorylation in rat brain modulated by carboxylmethylation?. J. Neurochem. 1985 May; 44(5): 1442-50. PMID: 3989542, ISSN: 0022-3042.

Vallano ML, Goldenring JR, Buckholz TM, Larson RE, DeLorenzo RJ. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc. Natl. Acad. Sci. U.S.A. 1985 May; 82(10): 3202-6. PMID: 3858817, PMCID: PMC397743, ISSN: 0027-8424.

Larson RE, Goldenring JR, Vallano ML, DeLorenzo RJ. Identification of endogenous calmodulin-dependent kinase and calmodulin-binding proteins in cold-stable microtubule preparations from rat brain. J. Neurochem. 1985 May; 44(5): 1566-74. PMID: 2985755, ISSN: 0022-3042.

Goldenring JR, Otis LC, Yu RK, DeLorenzo RJ. Calcium/ganglioside-dependent protein kinase activity in rat brain membrane. J. Neurochem. 1985 Apr; 44(4): 1229-34. PMID: 2579206, ISSN: 0022-3042.

GOLDENRING, J.R., Vallano, M.L. and DeLorenzo, R.J. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J. Neurochem. 1985; 45: 900-5.

Vallano, M.L., GOLDENRING, J.R., Buckholz, T.M., Larson, R.E. and DeLorenzo, R.J. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc. Natl. Acad. Sci., USA. 1985; 82: 3202-6.

Goldenring JR, Casanova JE, DeLorenzo RJ. Tubulin-associated calmodulin-dependent kinase: evidence for an endogenous complex of tubulin with a calcium-calmodulin-dependent kinase. J. Neurochem. 1984 Dec; 43(6): 1669-79. PMID: 6092543, ISSN: 0022-3042.

Goldenring JR, McGuire JS, DeLorenzo RJ. Identification of the major postsynaptic density protein as homologous with the major calmodulin-binding subunit of a calmodulin-dependent protein kinase. J. Neurochem. 1984 Apr; 42(4): 1077-84. PMID: 6699638, ISSN: 0022-3042.

Goldenring JR, Gonzalez B, McGuire JS, DeLorenzo RJ. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins. J. Biol. Chem. 1983 Oct 10/25/1983; 258(20): 12632-40. PMID: 6313669, ISSN: 0021-9258.

GOLDENRING, J.R., Gonzalez, B., McGuire, J.S., Jr. and DeLorenzo, R.J. 258: 12632-12640. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule associated proteins. J. Biol. Chem. 1983; 258: 12632-40.

Goldenring JR, Gonzalez B, DeLorenzo RJ. Isolation of brain Ca2+-calmodulin tubulin kinase containing calmodulin binding proteins. Biochem. Biophys. Res. Commun. 1982 Sep 9/16/1982; 108(1): 421-8. PMID: 6293491, PII: 0006-291X(82)91883-6, ISSN: 0006-291X.

Goldenring JR, Shaywitz BA, Wool RS, Batter DK, Anderson GM, Cohen DJ. Environmental and biologic interactions on behavior: effects of artificial rearing in rat pups treated with 6-hydroxydopamine. Dev Psychobiol. 1982 Jul; 15(4): 297-307. PMID: 6809512, DOI: 10.1002/dev.420150403, ISSN: 0012-1630.

Goldenring JR, Batter DK, Shaywitz BA. Sulfanilic acid: behavioral change related to azo food dyes in developing rats. Neurobehav Toxicol Teratol. 1982 Jan; 4(1): 43-9. PMID: 6803178, ISSN: 0275-1380.

Goldenring JR, Wool RS, Shaywitz BA, Batter DK, Cohen DJ, Young JG, Teicher MH. Effects of continuous gastric infusion of food dyes on developing rat pups. Life Sci. 1980 Nov 11/17/1980; 27(20): 1897-904. PMID: 7464455, ISSN: 0024-3205.

Shaywitz BA, Goldenring JR, Wool RS. Effects of chronic administration of food colorings on activity levels and cognitive performance in developing rat pups treated with 6-hydroxydopamine. Neurobehav Toxicol. 1979; 1(1): 41-7. PMID: 551301, ISSN: 0191-3581.

Available Postdoctoral Position Details
Posted Position



Research in a multiply-funded, multidisciplinary program to investigate 1) the origin and progression of precancerous metaplasia in the stomach and 2) ,lineage alterations associated with mutations responsible for congenital diarrheal diseases. Research is focused on single cell analysis of pathological lineages using single cell RNA sequencing in correlation with hyperplexed immunofluorescence imaging.

Projects available:

• Single cell analysis of stem cell populations within pre-cancerous populations.

• Analysis of lineage maturation in the intestines of mice with KO of MYO5B (a model of Microvillous Inclusion Disease).

• Evaluation intrinsic immune cell populations in the stomach in induction and progression of metaplasia.

Candidates should have a MD and/or PhD degree with experience in bioinformatic analysis of single cell RNA sequencing including experience in R and/or Matlab analysis platforms.

Send CV and references to James Goldenring, MD, PhD, Epithelial Biology Center, MRB4 Rm. 10435G, Vanderbilt University School of Medicine, 2213 Garland Avenue, Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.




Research in a multiply-funded, multidisciplinary program to investigate the origin and progression of precancerous metaplasia in the stomach. Research is focused on questions of identity and function of pre-cancerous stem cells and the relationship of intrinsic and extrinsic immune cells as well as stromal cells to influence their progressive intestinalization and evolution to cancer. Projects available: • Single cell analysis of stem cell populations within pre-cancerous populations. • Evaluation of markers of metaplastic progression towards cancer. • Evaluation of the role of intrinsic immune cell populations in the stomach in induction and progression of metaplasia. • Identify intramucosal signals that can promote progression of metaplasia to neoplasia. These studies include a range of cell biological techniques including 3-dimensional and 2-dimensional organoid culture, live cell microscopy, confocal fluorescence microscopy, single cell RNA sequencing, bioinformatics, and multiplex fluorescence imaging and analysis. Candidates should have a MD and/or PhD degree with an interest in epithelial cancer biology.

Send CV and references to James Goldenring, MD, PhD, Epithelial Biology Center, MRB4 Rm. 10435G, Vanderbilt University School of Medicine, 2213 Garland Avenue, Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.



Research in a multiply NIH-funded program to investigate the roles of Rab11 interacting proteins and class V myosin motors (MYO5B) in regulating membrane trafficking in polarized intestinal epithelial cells. Investigations also seek to characterize trafficking deficits in congenital diarrhea syndromes and develop to develop therapeutic strategies for overcoming deficits in apical membrane trafficking. Projects available include: • Trafficking defects in MYO5B KO mice and enteroids and therapeutic approaches to ameliorating diarrhea in Microvillus Inclusion Disease (MVID). • Identification of trafficking pathways responsible for diarrhea in infants with loss of DGAT1. • Characterization of apical bulk endocytosis in MYO5B KO neonatal enterocytes. • Identification of the roles Rab11-FIP1 and Rab11-FIP2 as regulators of junctions and polarity, including the characterization of novel KO mouse models and the evaluation of recently identified biding proteins. • Characterization of apical trafficking defecits in the intestines of patients with congenital diarrhea of unknown origin with genomic analysis and development of enteroids from patients. These studies include a range of cell biological techniques including 3-dimensional and 2-dimensional enteroid cultures, live cell microscopy, confocal fluorescence microscopy, high throughput chemical library and siRNA library screening, whole exome sequencing analysis, and single cell RNA sequencing analysis. Candidates should have a MD and/or PhD degree with experience in cellular physiology and/or cellular biology.

Send CV and references to James Goldenring, MD, PhD, Epithelial Biology Center, MRB4 Rm. 10435G, Vanderbilt University School of Medicine, 2213 Garland Avenue, Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.