James David Chappell, Ph.D., M.D.

Research Associate Professor

jim.chappell@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Pediatrics
Education
M.D., Medicine, Vanderbilt University, Nashville, TennesseePh.D., Microbiology and Immunology, Vanderbilt University, Nashville, TennesseeM.S., Biology, Murray State University, Murray, KentuckyB.S., Biology, Murray State University, Murray, Kentucky
Office Address
D-7240 MCN, Division of Pediatric Infectious Diseases
Vanderbilt University Medical Center
1161 21st Ave. S.
Nashville, TN 37232
Research Description
Research in our laboratory concentrates on the etiology, epidemiology, prevention, and pathobiology of infectious diseases, with primary emphasis on the respiratory and enteric systems. Current projects in the laboratory include collaborative, multi-center studies of pediatric acute gastroenteritis (AGE) and pediatric and adult acute respiratory illness (ARI) with colleagues in the Departments of Pediatrics and Medicine.

The causes, prevalence, and prevention of pediatric AGE, especially rotavirus- and norovirus-attributable disease, is under investigation through prospective surveillance of ill and asymptomatic children. These efforts are aimed at evaluating ongoing rotavirus vaccine effectiveness and the evolving pathogen spectrum of pediatric AGE in the post-rotavirus vaccine era, information essential to the design of new vaccines and therapies for prevalent gastrointestinal infections.

ARI studies are principally focused on the prevalence, clinical presentation, vaccine-mediated prevention, and treatment of influenza infection. Major goals for this work are to accurately define the burden of influenza disease in hospitalized patients, quantify influenza vaccine effectiveness, and identify opportunities for reducing influenza-related morbidity and mortality through improved applications of vaccines and antiviral therapies. Companion research addresses the prevalence and clinical impact of other common respiratory pathogens, such as respiratory syncytial virus, among individuals hospitalized with ARI.

Other active projects in the laboratory include studies of microbe-host cell interactions, persistence, and antimicrobial susceptibility of the intracellular bacterial pathogen, Chlamydia pneumoniae. This organism is a well-known cause of upper and lower respiratory tract illness with the capacity to establish persistent infection. Research on C. pneumoniae involves characterization of the pathogen life cycle and response to antibiotic treatment using molecular, microscopic, and bacteriologic techniques applied to cell-culture models of infection. Results of these studies will inform understandings of C. pneumoniae persistence strategies in the intact host and guide design of therapeutic regimens that effectively eradicate infection.
Research Keywords
Microbiology, epidemiology, and prevention of respiratory and enteric infections
Publications
Foster MA, Iqbal J, Zhang C, McHenry R, Cleveland BE, Romero-Herazo Y, Fonnesbeck C, Payne DC, Chappell JD, Halasa N, Gómez-Duarte OG. Enteropathogenic and enteroaggregative E. coli in stools of children with acute gastroenteritis in Davidson County, Tennessee. Diagn. Microbiol. Infect. Dis [print-electronic]. 2015 Nov; 83(3): 319-24. PMID: 26298817, PMCID: PMC4618545, PII: S0732-8893(15)00278-3, DOI: 10.1016/j.diagmicrobio.2015.07.016, ISSN: 1879-0070.

Ahn A, Edwards KM, Grijalva CG, Self WH, Zhu Y, Chappell JD, Arnold SR, McCullers JA, Ampofo K, Pavia AT, Bramley AM, Jain S, Williams DJ. Secondhand Smoke Exposure and Illness Severity among Children Hospitalized with Pneumonia. J. Pediatr [print-electronic]. 2015 Oct; 167(4): 869-874.e1. PMID: 26231828, PMCID: PMC4586387, PII: S0022-3476(15)00687-3, DOI: 10.1016/j.jpeds.2015.06.049, ISSN: 1097-6833.

Diaz MH, Benitez AJ, Cross KE, Hicks LA, Kutty P, Bramley AM, Chappell JD, Hymas W, Patel A, Qi C, Williams DJ, Arnold SR, Ampofo K, Self WH, Grijalva CG, Anderson EJ, McCullers JA, Pavia AT, Wunderink RG, Edwards KM, Jain S, Winchell JM. Molecular Detection and Characterization of Mycoplasma pneumoniae Among Patients Hospitalized With Community-Acquired Pneumonia in the United States. Open Forum Infect Dis. 2015 Sep; 2(3): ofv106. PMID: 26284257, PMCID: PMC4536330, PII: ofv106, DOI: 10.1093/ofid/ofv106, ISSN: 2328-8957.

Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, Reed C, Grijalva CG, Anderson EJ, Courtney DM, Chappell JD, Qi C, Hart EM, Carroll F, Trabue C, Donnelly HK, Williams DJ, Zhu Y, Arnold SR, Ampofo K, Waterer GW, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, McCullers JA, Pavia AT, Edwards KM, Finelli L, . Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N. Engl. J. Med [print-electronic]. 2015 Jul 7/30/2015; 373(5): 415-27. PMID: 26172429, DOI: 10.1056/NEJMoa1500245, ISSN: 1533-4406.

Self WH, Williams DJ, Zhu Y, Ampofo K, Pavia AT, Chappell JD, Hymas WC, Stockmann C, Bramley AM, Schneider E, Erdman D, Finelli L, Jain S, Edwards KM, Grijalva CG. Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia. J. Infect. Dis [print-electronic]. 2015 Jul 7/14/2015; PMID: 26180044, PII: jiv323, DOI: 10.1093/infdis/jiv323, ISSN: 1537-6613.

Cohen DN, Lawson SK, Shaver AC, Du L, Nguyen HP, He Q, Johnson DB, Lumbang WA, Moody BR, Prescott JL, Chandra PK, Boyd AS, Zwerner JP, Robbins JB, Tyring SK, Rady PL, Chappell JD, Shyr Y, Infante JR, Sosman JA. Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy. Clin. Cancer Res [print-electronic]. 2015 Jun 6/1/2015; 21(11): 2624-34. PMID: 25724524, PMCID: PMC4452444, PII: 1078-0432.CCR-14-2667, DOI: 10.1158/1078-0432.CCR-14-2667, ISSN: 1078-0432.

Wolf RB, Edwards K, Grijalva CG, Self WH, Zhu Y, Chappell J, Bramley AM, Jain S, Williams DJ. Time to clinical stability among children hospitalized with pneumonia. J Hosp Med [print-electronic]. 2015 Jun; 10(6): 380-3. PMID: 25919391, PMCID: PMC4456292, DOI: 10.1002/jhm.2370, ISSN: 1553-5606.

Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, Stockmann C, Anderson EJ, Grijalva CG, Self WH, Zhu Y, Patel A, Hymas W, Chappell JD, Kaufman RA, Kan JH, Dansie D, Lenny N, Hillyard DR, Haynes LM, Levine M, Lindstrom S, Winchell JM, Katz JM, Erdman D, Schneider E, Hicks LA, Wunderink RG, Edwards KM, Pavia AT, McCullers JA, Finelli L, . Community-acquired pneumonia requiring hospitalization among U.S. children. N. Engl. J. Med. 2015 Feb 2/26/2015; 372(9): 835-45. PMID: 25714161, DOI: 10.1056/NEJMoa1405870, ISSN: 1533-4406.

Larkin EK, Gebretsadik T, Moore ML, Anderson LJ, Dupont WD, Chappell JD, Minton PA, Peebles RS, Moore PE, Valet RS, Arnold DH, Rosas-Salazar C, Das SR, Polack FP, Hartert TV, . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med. 2015; 15: 45. PMID: 26021723, PMCID: PMC4506623, PII: 10.1186/s12890-015-0040-0, DOI: 10.1186/s12890-015-0040-0, ISSN: 1471-2466.

Hood JL, Morabito MV, Martinez CR, Gilbert JA, Ferrick EA, Ayers GD, Chappell JD, Dermody TS, Emeson RB. Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions. Mol. Cell. Neurosci [print-electronic]. 2014 Jul; 61: 97-109. PMID: 24906008, PMCID: PMC4134954, PII: S1044-7431(14)00062-1, DOI: 10.1016/j.mcn.2014.06.001, ISSN: 1095-9327.

Dennis AF, McDonald SM, Payne DC, Mijatovic-Rustempasic S, Esona MD, Edwards KM, Chappell JD, Patton JT. Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype. J. Virol [print-electronic]. 2014 Apr; 88(7): 3789-801. PMID: 24429371, PMCID: PMC3993531, PII: JVI.03516-13, DOI: 10.1128/JVI.03516-13, ISSN: 1098-5514.

Tate JE, Mijatovic-Rustempasic S, Tam KI, Lyde FC, Payne DC, Szilagyi P, Edwards K, Staat MA, Weinberg GA, Hall CB, Chappell J, McNeal M, Gentsch JR, Bowen MD, Parashar UD. Comparison of 2 assays for diagnosing rotavirus and evaluating vaccine effectiveness in children with gastroenteritis. Emerging Infect. Dis. 2013 Aug; 19(8): 1245-52. PMID: 23876518, PMCID: PMC3739503, DOI: 10.3201/eid1908.130461, ISSN: 1080-6059.

Payne DC, Boom JA, Staat MA, Edwards KM, Szilagyi PG, Klein EJ, Selvarangan R, Azimi PH, Harrison C, Moffatt M, Johnston SH, Sahni LC, Baker CJ, Rench MA, Donauer S, McNeal M, Chappell J, Weinberg GA, Tasslimi A, Tate JE, Wikswo M, Curns AT, Sulemana I, Mijatovic-Rustempasic S, Esona MD, Bowen MD, Gentsch JR, Parashar UD. Effectiveness of pentavalent and monovalent rotavirus vaccines in concurrent use among US children <5 years of age, 2009-2011. Clin. Infect. Dis [print-electronic]. 2013 Jul; 57(1): 13-20. PMID: 23487388, PMCID: PMC4618548, PII: cit164, DOI: 10.1093/cid/cit164, ISSN: 1537-6591.

Donauer S, Payne DC, Edwards KM, Szilagyi PG, Hornung RW, Weinberg GA, Chappell J, Hall CB, Parashar UD, Staat MA. Determining the effectiveness of the pentavalent rotavirus vaccine against rotavirus hospitalizations and emergency department visits using two study designs. Vaccine [print-electronic]. 2013 May 5/31/2013; 31(24): 2692-7. PMID: 23583814, PMCID: PMC4618546, PII: S0264-410X(13)00418-0, DOI: 10.1016/j.vaccine.2013.03.072, ISSN: 1873-2518.

Esbenshade JC, Edwards KM, Esbenshade AJ, Rodriguez VE, Talbot HK, Joseph MF, Nwosu SK, Chappell JD, Gern JE, Williams JV, Talbot TR. Respiratory virus shedding in a cohort of on-duty healthcare workers undergoing prospective surveillance. Infect Control Hosp Epidemiol [print-electronic]. 2013 Apr; 34(4): 373-8. PMID: 23466910, PMCID: PMC3730277, DOI: 10.1086/669857, ISSN: 1559-6834.

Payne DC, Vinjé J, Szilagyi PG, Edwards KM, Staat MA, Weinberg GA, Hall CB, Chappell J, Bernstein DI, Curns AT, Wikswo M, Shirley SH, Hall AJ, Lopman B, Parashar UD. Norovirus and medically attended gastroenteritis in U.S. children. N. Engl. J. Med. 2013 Mar 3/21/2013; 368(12): 1121-30. PMID: 23514289, PMCID: PMC4618551, DOI: 10.1056/NEJMsa1206589, ISSN: 1533-4406.

JD Chappell. Laboratory diagnosis of viral myocarditis. 2013.

Tang YW, Lowery KS, Valsamakis A, Schaefer VC, Chappell JD, White-Abell J, Quinn CD, Li H, Washington CA, Cromwell J, Giamanco CM, Forman M, Holden J, Rothman RE, Parker ML, Ortenberg EV, Zhang L, Lin YL, Gaydos CA. Clinical accuracy of a PLEX-ID flu device for simultaneous detection and identification of influenza viruses A and B. J. Clin. Microbiol [print-electronic]. 2013 Jan; 51(1): 40-5. PMID: 23077123, PMCID: PMC3536229, PII: JCM.01978-12, DOI: 10.1128/JCM.01978-12, ISSN: 1098-660X.

Self WH, McNaughton CD, Grijalva CG, Zhu Y, Chappell JD, Williams JV, Talbot HK, Shay DK, Griffin MR. Diagnostic performance of the BinaxNow Influenza A&B rapid antigen test in ED patients. Am J Emerg Med [print-electronic]. 2012 Nov; 30(9): 1955-61. PMID: 22795995, PII: S0735-6757(12)00182-9, DOI: 10.1016/j.ajem.2012.04.018, ISSN: 1532-8171.

Ooms LS, Jerome WG, Dermody TS, Chappell JD. Reovirus replication protein µ2 influences cell tropism by promoting particle assembly within viral inclusions. J. Virol [print-electronic]. 2012 Oct; 86(20): 10979-87. PMID: 22837214, PMCID: PMC3457141, PII: JVI.01172-12, DOI: 10.1128/JVI.01172-12, ISSN: 1098-5514.

McDonald SM, McKell AO, Rippinger CM, McAllen JK, Akopov A, Kirkness EF, Payne DC, Edwards KM, Chappell JD, Patton JT. Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics. J. Virol [print-electronic]. 2012 Sep; 86(17): 9148-62. PMID: 22696651, PMCID: PMC3416154, PII: JVI.01105-12, DOI: 10.1128/JVI.01105-12, ISSN: 1098-5514.

Irvin SC, Zurney J, Ooms LS, Chappell JD, Dermody TS, Sherry B. A single-amino-acid polymorphism in reovirus protein µ2 determines repression of interferon signaling and modulates myocarditis. J. Virol [print-electronic]. 2012 Feb; 86(4): 2302-11. PMID: 22156521, PMCID: PMC3302381, PII: JVI.06236-11, DOI: 10.1128/JVI.06236-11, ISSN: 1098-5514.

McClain CM, Van Horn GT, Chappell JD, Stratton CW. Coccidioides, cryptococcus, or blastomyces? A diagnostic dilemma encountered during frozen section evaluation. Pediatr. Dev. Pathol [print-electronic]. 2012 Jan; 15(1): 71-5. PMID: 21815826, DOI: 10.2350/11-01-0973-CR.1, ISSN: 1093-5266.

Attoui, H, Baker, TS, Bamford, DH, Becnel, J, Belaganahalli, S, Bergoin, M, Brussaard, CP, Castón, JR, Chappell, JD, Ciarlet, M, del Vas, M, Delmas, B, Dermody, TS, Dormitzer, PR, Duncan, R, Fang, Q, Fukuhara, T, Ghabrial, SA, Gibbs, MJ, Graham, R, Guglielmi, KM, Harding, RM, Hillman, BI, Lesker, T, Maan, M, Maiss, E, Makkay, A, Marzachì, R, Matthijnssens, J, Mertens, PPC, Milne, RG, Mohd Jaafar, F, Mori, H, Mundt, E, Nibert, ML, Noordeloos, AA, Nuss, DL, Omura, T, Patterson, JL, Patton, JT, Poranen, MM, Rao, S, Stoltz, D, Suzuki, N, Tao, YJ, Upadhyaya, NM, Vakharia, VN, Wang, CC, Wei, C, Wickner, RB, Wu, JL, and H Zhou. Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. [place unknown: publisher unknown]; 2012.

Payne DC, Staat MA, Edwards KM, Szilagyi PG, Weinberg GA, Hall CB, Chappell J, Curns AT, Wikswo M, Tate JE, Lopman BA, Parashar UD, . Direct and indirect effects of rotavirus vaccination upon childhood hospitalizations in 3 US Counties, 2006-2009. Clin. Infect. Dis [print-electronic]. 2011 Aug 8/1/2011; 53(3): 245-53. PMID: 21705316, PII: cir307, DOI: 10.1093/cid/cir307, ISSN: 1537-6591.

Monsalvo AC, Batalle JP, Lopez MF, Krause JC, Klemenc J, Hernandez JZ, Maskin B, Bugna J, Rubinstein C, Aguilar L, Dalurzo L, Libster R, Savy V, Baumeister E, Aguilar L, Cabral G, Font J, Solari L, Weller KP, Johnson J, Echavarria M, Edwards KM, Chappell JD, Crowe JE, Williams JV, Melendi GA, Polack FP. Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes. Nat. Med [print-electronic]. 2011 Feb; 17(2): 195-9. PMID: 21131958, PMCID: PMC3034774, PII: nm.2262, DOI: 10.1038/nm.2262, ISSN: 1546-170X.

Dermody, TS, and JD Chappell. Fundamentals of Molecular Virology, 2nd Edition. [place unknown: publisher unknown]; 2011.

Ooms LS, Kobayashi T, Dermody TS, Chappell JD. A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism. J. Biol. Chem [print-electronic]. 2010 Dec 12/31/2010; 285(53): 41604-13. PMID: 20978124, PMCID: PMC3009888, PII: M110.176255, DOI: 10.1074/jbc.M110.176255, ISSN: 1083-351X.

O'Leary MF, Chappell JD, Stratton CW, Cronin RM, Taylor MB, Tang YW. Complex febrile seizures followed by complete recovery in an infant with high-titer 2009 pandemic influenza A (H1N1) virus infection. J. Clin. Microbiol [print-electronic]. 2010 Oct; 48(10): 3803-5. PMID: 20702660, PMCID: PMC2953069, PII: JCM.00825-10, DOI: 10.1128/JCM.00825-10, ISSN: 1098-660X.

Dulek DE, Williams JV, Creech CB, Schulert AK, Frangoul HA, Domm J, Denison MR, Chappell JD. Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. Clin. Infect. Dis. 2010 Jun 6/1/2010; 50(11): 1493-6. PMID: 20415572, DOI: 10.1086/652655, ISSN: 1537-6591.

Kobayashi T, Ooms LS, Ikizler M, Chappell JD, Dermody TS. An improved reverse genetics system for mammalian orthoreoviruses. Virology [print-electronic]. 2010 Mar 3/15/2010; 398(2): 194-200. PMID: 20042210, PMCID: PMC2823833, PII: S0042-6822(09)00773-9, DOI: 10.1016/j.virol.2009.11.037, ISSN: 1096-0341.

Libster R, Bugna J, Coviello S, Hijano DR, Dunaiewsky M, Reynoso N, Cavalieri ML, Guglielmo MC, Areso MS, Gilligan T, Santucho F, Cabral G, Gregorio GL, Moreno R, Lutz MI, Panigasi AL, Saligari L, Caballero MT, Egües Almeida RM, Gutierrez Meyer ME, Neder MD, Davenport MC, Del Valle MP, Santidrian VS, Mosca G, Garcia Domínguez M, Alvarez L, Landa P, Pota A, Boloñati N, Dalamon R, Sanchez Mercol VI, Espinoza M, Peuchot JC, Karolinski A, Bruno M, Borsa A, Ferrero F, Bonina A, Ramonet M, Albano LC, Luedicke N, Alterman E, Savy V, Baumeister E, Chappell JD, Edwards KM, Melendi GA, Polack FP. Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina. N. Engl. J. Med [print-electronic]. 2010 Jan 1/7/2010; 362(1): 45-55. PMID: 20032320, PII: NEJMoa0907673, DOI: 10.1056/NEJMoa0907673, ISSN: 1533-4406.

Johnson EM, Doyle JD, Wetzel JD, McClung RP, Katunuma N, Chappell JD, Washington MK, Dermody TS. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J. Virol [print-electronic]. 2009 Oct; 83(19): 9630-40. PMID: 19640986, PMCID: PMC2748054, PII: JVI.01095-09, DOI: 10.1128/JVI.01095-09, ISSN: 1098-5514.

Kobayashi T, Ooms LS, Chappell JD, Dermody TS. Identification of functional domains in reovirus replication proteins muNS and mu2. J. Virol [print-electronic]. 2009 Apr; 83(7): 2892-906. PMID: 19176625, PMCID: PMC2655549, PII: JVI.01495-08, DOI: 10.1128/JVI.01495-08, ISSN: 1098-5514.

Sato M, Li H, Ikizler MR, Werkhaven JA, Williams JV, Chappell JD, Tang YW, Wright PF. Detection of viruses in human adenoid tissues by use of multiplex PCR. J. Clin. Microbiol [print-electronic]. 2009 Mar; 47(3): 771-3. PMID: 19116356, PMCID: PMC2650959, PII: JCM.02331-08, DOI: 10.1128/JCM.02331-08, ISSN: 1098-660X.

Chappell, JD, and TS Dermody. Introduction to viruses and viral diseases. In: Mandell, GL, Bennett, JE, and R. Dolin (eds.): Principles and Practice of Infectious Diseases, 7th ed. Elsevier, Philadelphia. pp 1907-1921. [place unknown: publisher unknown]; 2009.

Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004-2006. Clin. Infect. Dis [print-electronic]. 2007 Nov 11/1/2007; 45(9): 1120-31. PMID: 17918073, PMCID: PMC2064001, PII: CID51088, DOI: 10.1086/522188, ISSN: 1537-6591.

Li H, McCormac MA, Estes RW, Sefers SE, Dare RK, Chappell JD, Erdman DD, Wright PF, Tang YW. Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections. J. Clin. Microbiol [print-electronic]. 2007 Jul; 45(7): 2105-9. PMID: 17507510, PMCID: PMC1932978, PII: JCM.00210-07, DOI: 10.1128/JCM.00210-07, ISSN: 0095-1137.

Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 4/19/2007; 1(2): 147-57. PMID: 18005692, PMCID: PMC2034303, PII: S1931-3128(07)00042-X, DOI: 10.1016/j.chom.2007.03.003, ISSN: 1934-6069.

Kobayashi T, Chappell JD, Danthi P, Dermody TS. Gene-specific inhibition of reovirus replication by RNA interference. J. Virol. 2006 Sep; 80(18): 9053-63. PMID: 16940517, PMCID: PMC1563907, PII: 80/18/9053, DOI: 10.1128/JVI.00276-06, ISSN: 0022-538X.

Wetzel JD, Barton ES, Chappell JD, Baer GS, Mochow-Grundy M, Rodgers SE, Shyr Y, Powers AC, Thomas JW, Dermody TS. Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. J. Virol. 2006 Mar; 80(6): 3078-82. PMID: 16501117, PMCID: PMC1395416, PII: 80/6/3078, DOI: 10.1128/JVI.80.6.3078-3082.2006, ISSN: 0022-538X.

Dermody, TS, and JD Chappell. [place unknown: publisher unknown]; 2006.

O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J. Clin. Invest [print-electronic]. 2005 Sep; 115(9): 2341-50. PMID: 16100570, PMCID: PMC1184036, DOI: 10.1172/JCI22428, ISSN: 0021-9738.

Chappell, JD Duncan, R Mertens, PPC Dermody, TS. Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses. [place unknown: publisher unknown]; 2005.

Mercier GT, Campbell JA, Chappell JD, Stehle T, Dermody TS, Barry MA. A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Apr 4/20/2004; 101(16): 6188-93. PMID: 15079060, PMCID: PMC395944, PII: 0400542101, DOI: 10.1073/pnas.0400542101, ISSN: 0027-8424.

Chappell JD, Prota AE, Dermody TS, Stehle T. Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J. 2002 Jan 1/15/2002; 21(1-2): 1-11. PMID: 11782420, PMCID: PMC125343, DOI: 10.1093/emboj/21.1.1, ISSN: 0261-4189.

Barton ES, Chappell JD, Connolly JL, Forrest JC, Dermody TS. Reovirus receptors and apoptosis. Virology. 2001 Nov 11/25/2001; 290(2): 173-80. PMID: 11883182, PII: S0042-6822(01)91160-2, DOI: 10.1006/viro.2001.1160, ISSN: 0042-6822.

Chandran K, Zhang X, Olson NH, Walker SB, Chappell JD, Dermody TS, Baker TS, Nibert ML. Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J. Virol. 2001 Jun; 75(11): 5335-42. PMID: 11333914, PMCID: PMC114938, DOI: 10.1128/JVI.75.11.5335-5342.2001, ISSN: 0022-538X.

Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS. Junction adhesion molecule is a receptor for reovirus. Cell. 2001 Feb 2/9/2001; 104(3): 441-51. PMID: 11239401, PII: S0092-8674(01)00231-8, ISSN: 0092-8674.

Barton ES, Connolly JL, Forrest JC, Chappell JD, Dermody TS. Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J. Biol. Chem [print-electronic]. 2001 Jan 1/19/2001; 276(3): 2200-11. PMID: 11054410, PII: M004680200, DOI: 10.1074/jbc.M004680200, ISSN: 0021-9258.

Chappell JD, Duong JL, Wright BW, Dermody TS. Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. J. Virol. 2000 Sep; 74(18): 8472-9. PMID: 10954547, PMCID: PMC116358, ISSN: 0022-538X.

Rodgers SE, Connolly JL, Chappell JD, Dermody TS. Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant. J. Virol. 1998 Nov; 72(11): 8597-604. PMID: 9765398, PMCID: PMC110270, ISSN: 0022-538X.

Chappell JD, Barton ES, Smith TH, Baer GS, Duong DT, Nibert ML, Dermody TS. Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck. J. Virol. 1998 Oct; 72(10): 8205-13. PMID: 9733863, PMCID: PMC110170, ISSN: 0022-538X.

Chappell JD, Gunn VL, Wetzel JD, Baer GS, Dermody TS. Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1. J. Virol. 1997 Mar; 71(3): 1834-41. PMID: 9032313, PMCID: PMC191253, ISSN: 0022-538X.

Wetzel JD, Chappell JD, Fogo AB, Dermody TS. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J. Virol. 1997 Jan; 71(1): 299-306. PMID: 8985350, PMCID: PMC191051, ISSN: 0022-538X.

Dermody TS, Chappell JD, Hofler JG, Kramp W, Tyler KL. Eradication of persistent reovirus infection from a B-cell hybridoma. Virology. 1995 Sep 9/10/1995; 212(1): 272-6. PMID: 7676645, PII: S0042-6822(85)71483-3, DOI: 10.1006/viro.1995.1483, ISSN: 0042-6822.

Nibert ML, Chappell JD, Dermody TS. Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. J. Virol. 1995 Aug; 69(8): 5057-67. PMID: 7609075, PMCID: PMC189323, ISSN: 0022-538X.

Chapell JD, Goral MI, Rodgers SE, dePamphilis CW, Dermody TS. Sequence diversity within the reovirus S2 gene: reovirus genes reassort in nature, and their termini are predicted to form a panhandle motif. J. Virol. 1994 Feb; 68(2): 750-6. PMID: 8289378, PMCID: PMC236511, ISSN: 0022-538X.

Chappell JD, Stuart JG. Demonstration of protection in mice from a lethal challenge of three M serotypes of Streptococcus pyogenes using an M-negative vaccine. Vaccine. 1993; 11(6): 643-8. PMID: 8322487, ISSN: 0264-410X.

Pratt, JR, and JD Chappell. Abundance and feeding of microheterotrophic flagellates from a eutrophic lake. Hydrobiologia. 1989; 182: 165-9.

Chappell, JD, and TS Dermody. Biology of viruses and viral diseases. In: Bennett, JE, Dolin, R, and MJ Blaser (eds.): Principles and Practice of Infectious Diseases, 8th ed. Elsevier, Philadelphia. pp 1681-1693. , 2015.