Emily M. Garland, Ph.D.

Research Associate Professor

emily.garland@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Medicine
Education
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseePh.D., Biochemical Pharmacology, University of Maryland, College Park, MarylandB.S., Psychology, Duke University, Durham, North Carolina
Office Address
AA-3228 MCN
Clinical Pharmacology
1161 21st Avenue South
Nashville, TN 2195
Research Description
I am interested in how the autonomic nervous system regulates blood pressure and heart rate. We are studying relevant mechanisms in patients with autonomic impairment and in mouse models. I am also interested in how kidney mechanisms can modify blood pressure and body fluid levels.
Research Keywords
Autonomic control of blood pressure
Publications
Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA. Hyperinsulinemia and Insulin Resistance in Dopamine ß-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab [print-electronic]. 2016 Oct 10/25/2016; jc20163274. PMID: 27778639, DOI: 10.1210/jc.2016-3274, ISSN: 1945-7197.

Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I. Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2015 Dec 12/15/2015; 309(12): H2098-107. PMID: 26453329, PMCID: PMC4698423, PII: ajpheart.00409.2015, DOI: 10.1152/ajpheart.00409.2015, ISSN: 1522-1539.

Garland EM, Celedonio JE, Raj SR. Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance. Curr Neurol Neurosci Rep. 2015 Sep; 15(9): 60. PMID: 26198889, PMCID: PMC4664448, DOI: 10.1007/s11910-015-0583-8, ISSN: 1534-6293.

Mar PL, Shibao CA, Garland EM, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Robertson D, Raj SR. Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline). Clin. Sci. 2015 Jul; 129(2): 107-16. PMID: 25706983, PMCID: PMC4417057, PII: CS20140766, DOI: 10.1042/CS20140766, ISSN: 1470-8736.

Arnold AC, Haman K, Garland EM, Raj V, Dupont WD, Biaggioni I, Robertson D, Raj SR. Cognitive dysfunction in postural tachycardia syndrome. Clin. Sci. 2015 Jan; 128(1): 39-45. PMID: 25001527, PMCID: PMC4161607, PII: CS20140251, DOI: 10.1042/CS20140251, ISSN: 1470-8736.

Mai TH, Wu J, Diedrich A, Garland EM, Robertson D. Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure. J Am Soc Hypertens [print-electronic]. 2014 May; 8(5): 286-96. PMID: 24746612, PMCID: PMC4072204, PII: S1933-1711(14)00093-X, DOI: 10.1016/j.jash.2014.03.001, ISSN: 1878-7436.

Ferguson MC, Garland EM, Hedges L, Womack-Nunley B, Hamid R, Phillips JA, Shibao CA, Raj SR, Biaggioni I, Robertson D. SHC2 gene copy number in multiple system atrophy (MSA). Clin. Auton. Res [print-electronic]. 2014 Feb; 24(1): 25-30. PMID: 24170347, PMCID: PMC3946192, DOI: 10.1007/s10286-013-0216-8, ISSN: 1619-1560.

Phillips L, Robertson D, Melson MR, Garland EM, Joos KM. Pediatric ptosis as a sign of treatable autonomic dysfunction. Am. J. Ophthalmol [print-electronic]. 2013 Aug; 156(2): 370-374.e2. PMID: 23622564, PMCID: PMC3720787, PII: S0002-9394(13)00173-6, DOI: 10.1016/j.ajo.2013.03.009, ISSN: 1879-1891.

Garland EM, Cesar TS, Lonce S, Ferguson MC, Robertson D. An increase in renal dopamine does not stimulate natriuresis after fava bean ingestion. Am. J. Clin. Nutr [print-electronic]. 2013 May; 97(5): 1144-50. PMID: 23553159, PMCID: PMC3628380, PII: ajcn.112.048470, DOI: 10.3945/ajcn.112.048470, ISSN: 1938-3207.

Plash WB, Diedrich A, Biaggioni I, Garland EM, Paranjape SY, Black BK, Dupont WD, Raj SR. Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics. Clin. Sci. 2013 Jan; 124(2): 109-14. PMID: 22931296, PMCID: PMC3478101, PII: CS20120276, DOI: 10.1042/CS20120276, ISSN: 1470-8736.

Garland EM, Hooper WB, Robertson D. Pure autonomic failure. Handb Clin Neurol. 2013; 117: 243-57. PMID: 24095130, PII: B978-0-444-53491-0.00020-1, DOI: 10.1016/B978-0-444-53491-0.00020-1, ISSN: 0072-9752.

Peltier AC, Bagai K, Artibee K, Diedrich A, Garland E, Elasy T, Shi Y, Wang L, Feldman EL, Robertson D, Malow BA. Effect of mild hyperglycemia on autonomic function in obstructive sleep apnea. Clin. Auton. Res [print-electronic]. 2012 Feb; 22(1): 1-8. PMID: 21796355, PMCID: PMC3925507, DOI: 10.1007/s10286-011-0131-9, ISSN: 1619-1560.

Brewster JA, Garland EM, Biaggioni I, Black BK, Ling JF, Shibao CA, Robertson D, Raj SR. Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndrome. Clin. Sci. 2012 Jan; 122(1): 25-31. PMID: 21751966, PMCID: PMC3172399, PII: CS20110077, DOI: 10.1042/CS20110077, ISSN: 1470-8736.

Mustafa HI, Garland EM, Biaggioni I, Black BK, Dupont WD, Robertson D, Raj SR. Abnormalities of angiotensin regulation in postural tachycardia syndrome. Heart Rhythm [print-electronic]. 2011 Mar; 8(3): 422-8. PMID: 21266211, PMCID: PMC3050076, PII: S1547-5271(10)01204-X, DOI: 10.1016/j.hrthm.2010.11.009, ISSN: 1556-3871.

Garland EM, Raj SR, Peltier AC, Robertson D, Biaggioni I. A cross-sectional study contrasting olfactory function in autonomic disorders. Neurology. 2011 Feb 2/1/2011; 76(5): 456-60. PMID: 21282592, PMCID: PMC3034411, PII: 76/5/456, DOI: 10.1212/WNL.0b013e31820a0caf, ISSN: 1526-632X.

Peltier AC, Garland E, Raj SR, Sato K, Black B, Song Y, Wang L, Biaggioni I, Diedrich A, Robertson D. Distal sudomotor findings in postural tachycardia syndrome. Clin. Auton. Res [print-electronic]. 2010 Apr; 20(2): 93-9. PMID: 20035362, PMCID: PMC3089763, DOI: 10.1007/s10286-009-0045-y, ISSN: 1619-1560.

Garland EM, Gamboa A, Okamoto L, Raj SR, Black BK, Davis TL, Biaggioni I, Robertson D. Renal impairment of pure autonomic failure. Hypertension [print-electronic]. 2009 Nov; 54(5): 1057-61. PMID: 19738158, PMCID: PMC2796115, PII: HYPERTENSIONAHA.109.136853, DOI: 10.1161/HYPERTENSIONAHA.109.136853, ISSN: 1524-4563.

Shibao C, Garland EM, Gamboa A, Vnencak-Jones CL, Van Woeltz M, Haines JL, Yu C, Biaggioni I. PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's disease. Clin. Auton. Res [print-electronic]. 2008 Feb; 18(1): 13-9. PMID: 18236005, DOI: 10.1007/s10286-007-0447-7, ISSN: 0959-9851.

Garland EM, Raj SR, Black BK, Harris PA, Robertson D. The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome. Neurology. 2007 Aug 8/21/2007; 69(8): 790-8. PMID: 17709712, PII: 69/8/790, DOI: 10.1212/01.wnl.0000267663.05398.40, ISSN: 1526-632X.

Garland EM, Black BK, Harris PA, Robertson D. Dopamine-beta-hydroxylase in postural tachycardia syndrome. Am. J. Physiol. Heart Circ. Physiol. 2007 Jul; 293(1): H684-90. PMID: 17625104, PII: 293/1/H684, DOI: 10.1152/ajpheart.01389.2006, ISSN: 0363-6135.

Jacob G, Garland EM, Costa F, Stein CM, Xie HG, Robertson RM, Biaggioni I, Robertson D. Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome. Hypertension [print-electronic]. 2006 Mar; 47(3): 421-7. PMID: 16461848, PII: 01.HYP.0000205120.46149.34, DOI: 10.1161/01.HYP.0000205120.46149.34, ISSN: 1524-4563.

Garland EM, Raj SR, Demartinis N, Robertson D. Case report: Marathon runner with severe autonomic failure. Lancet. 2005 Dec; 366 Suppl 1: S13. PMID: 16360730, PII: S0140-6736(05)67826-9, DOI: 10.1016/S0140-6736(05)67826-9, ISSN: 1474-547X.

Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA, Harris PA, Rüdiger H, Robertson D. Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Hypertension [print-electronic]. 2005 Nov; 46(5): 1103-10. PMID: 16203873, PII: 01.HYP.0000185462.08685.da, DOI: 10.1161/01.HYP.0000185462.08685.da, ISSN: 1524-4563.

Winker R, Garland EM, Rüdiger HW, Diedrich A, Biaggioni I, Ponocny I, Cascorbi I, Robertson D. Influence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intolerance. Am. J. Med. Sci. 2005 Oct; 330(4): 166-71. PMID: 16234608, PII: 00000441-200510000-00003, ISSN: 0002-9629.

Garland EM, Vnencak-Jones CL, Biaggioni I, Davis TL, Montine TJ, Robertson D. Fragile X gene premutation in multiple system atrophy. J. Neurol. Sci. 2004 Dec 12/15/2004; 227(1): 115-8. PMID: 15546601, PII: S0022-510X(04)00320-X, DOI: 10.1016/j.jns.2004.08.013, ISSN: 0022-510X.

Vincent S, Bieck PR, Garland EM, Loghin C, Bymaster FP, Black BK, Gonzales C, Potter WZ, Robertson D. Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles. Circulation [print-electronic]. 2004 Jun 6/29/2004; 109(25): 3202-7. PMID: 15184278, PII: 01.CIR.0000130847.18666.39, DOI: 10.1161/01.CIR.0000130847.18666.39, ISSN: 1524-4539.

Garland EM, Anderson JC, Black BK, Kessler RM, Konrad PE, Robertson D. No increased herniation of the cerebellar tonsils in a group of patients with orthostatic intolerance. Clin. Auton. Res. 2002 Dec; 12(6): 472-6. PMID: 12598952, DOI: 10.1007/s10286-002-0051-9, ISSN: 0959-9851.

Garland EM, Hahn MK, Ketch TP, Keller NR, Kim CH, Kim KS, Biaggioni I, Shannon JR, Blakely RD, Robertson D. Genetic basis of clinical catecholamine disorders. Ann. N. Y. Acad. Sci. 2002 Oct; 971: 506-14. PMID: 12438171, ISSN: 0077-8923.

Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I. Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem. Pharmacol. 2001 Nov 11/1/2001; 62(9): 1163-73. PMID: 11705449, PII: S0006295201007651, ISSN: 0006-2952.

Garland EM, Robertson D. Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?. Am. J. Med. 2001 Nov; 111(7): 546-52. PMID: 11705431, PII: S0002-9343(01)00922-6, ISSN: 0002-9343.

Robertson D, Shannon JR, Jordan J, Davis TL, Diedrich A, Jacob G, Garland E, Tellioglu T, Biaggioni I. Multiple system atrophy: new developments in pathophysiology and therapy. Parkinsonism Relat. Disord. 2001 Jul; 7(3): 257-60. PMID: 11331196, PII: S1353-8020(00)00067-5, ISSN: 1873-5126.

Robertson D, Flattem N, Tellioglu T, Carson R, Garland E, Shannon JR, Jordan J, Jacob G, Blakely RD, Biaggioni I. Familial orthostatic tachycardia due to norepinephrine transporter deficiency. Ann. N. Y. Acad. Sci. 2001 Jun; 940: 527-43. PMID: 11458707, ISSN: 0077-8923.

Garland EM, Biaggioni I. Genetic polymorphisms of adrenergic receptors. Clin. Auton. Res. 2001 Apr; 11(2): 67-78. PMID: 11570606, ISSN: 0959-9851.

Cohen SM, Arnold LL, Cano M, Ito M, Garland EM, Shaw RA. Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats. Carcinogenesis. 2000 Apr; 21(4): 783-92. PMID: 10753216, ISSN: 0143-3334.

Smith RA, Christenson WR, Bartels MJ, Arnold LL, St John MK, Cano M, Garland EM, Lake SG, Wahle BS, McNett DA, Cohen SM. Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats. Toxicol. Appl. Pharmacol. 1998 Jun; 150(2): 402-13. PMID: 9653072, PII: S0041-008X(98)98435-6, DOI: 10.1006/taap.1998.8435, ISSN: 0041-008X.

Efange SM, Garland EM, Staley JK, Khare AB, Mash DC. Vesicular acetylcholine transporter density and Alzheimer's disease. Neurobiol. Aging. 1997 Jul; 18(4): 407-13. PMID: 9330972, PII: S0197-4580(97)00038-9, ISSN: 0197-4580.

Cohen SM, Masui T, Garland EM, Arnold LL. Effects of diet on urinary bladder carcinogenesis and cancer prevention. J. Nutr. 1997 May; 127(5 Suppl): 826S-829S. PMID: 9164246, ISSN: 0022-3166.

Cohen SM, Cano M, Anderson T, Garland EM. Extensive handling of rats leads to mild urinary bladder hyperplasia. Toxicol Pathol. 1996 Mar; 24(2): 251-7. PMID: 8992616, ISSN: 0192-6233.

Cohen SM, Garland EM, Cano M, St John MK, Khachab M, Wehner JM, Arnold LL. Effects of sodium ascorbate, sodium saccharin and ammonium chloride on the male rat urinary bladder. Carcinogenesis. 1995 Nov; 16(11): 2743-50. PMID: 7586194, ISSN: 0143-3334.

Cohen SM, Cano M, St John MK, Garland EM, Khachab M, Ellwein LB. Effect of sodium saccharin on the neonatal rat bladder. Scanning Microsc. 1995 Mar; 9(1): 137-47; discussion 148. PMID: 8553012, ISSN: 0891-7035.

Cohen SM, Cano M, Garland EM, St John M, Arnold LL. Urinary and urothelial effects of sodium salts in male rats. Carcinogenesis. 1995 Feb; 16(2): 343-8. PMID: 7859367, ISSN: 0143-3334.

Garland EM, Cohen SM. Saccharin-induced bladder cancer in rats. Prog. Clin. Biol. Res. 1995; 391: 237-43. PMID: 8532721, ISSN: 0361-7742.

Cohen SM, Cano M, Johnson LS, StJohn MK, Asamoto M, Garland EM, Thyssen JH, Sangha GK, van Goethem DL. Mitogenic effects of propoxur on male rat bladder urothelium. Carcinogenesis. 1994 Nov; 15(11): 2593-7. PMID: 7955111, ISSN: 0143-3334.

Okamura T, Garland EM, Cohen SM. Glandular stomach hemorrhage induced by high dose saccharin in young rodents. Toxicol. Lett. 1994 Nov; 74(2): 129-40. PMID: 7940594, ISSN: 0378-4274.

Garland EM, St John M, Asamoto M, Eklund SH, Mattson BJ, Johnson LS, Cano M, Cohen SM. A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats. Cancer Lett. 1994 Apr 4/1/1994; 78(1-3): 99-107. PMID: 7514092, ISSN: 0304-3835.

Garland EM, Shapiro R, Wehner JM, Johnson LS, Mattson BJ, Khachab M, Asamoto M, Cohen SM. Effects of dietary iron and folate supplementation on the physiological changes produced in weanling rats by sodium saccharin exposure. Food Chem. Toxicol. 1993 Oct; 31(10): 689-99. PMID: 8225126, ISSN: 0278-6915.

Masui T, Mann AM, Borgeson CD, Garland EM, Okamura T, Fujii H, Pelling JC, Cohen SM. Sequencing analysis of Ha-, Ki-, and N-ras genes in rat urinary bladder tumors induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin. Teratog., Carcinog. Mutagen. 1993; 13(5): 225-33. PMID: 7905676, ISSN: 0270-3211.

Okamura T, Garland EM, Taylor RJ, Johansson SL, Cohen SM. The effect of cyclophosphamide administration on the kidney of the rat. Toxicol. Lett. 1992 Dec; 63(3): 261-76. PMID: 1488776, ISSN: 0378-4274.

Masui T, Mann AM, Macatee TL, Okamura T, Garland EM, Smith RA, Cohen SM. Absence of ras oncogene activation in rat urinary bladder carcinomas induced by N-methyl-N-nitrosourea or N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis. 1992 Dec; 13(12): 2281-5. PMID: 1473235, ISSN: 0143-3334.

Cohen SM, Garland EM, St John M, Okamura T, Smith RA. Acrolein initiates rat urinary bladder carcinogenesis. Cancer Res. 1992 Jul 7/1/1992; 52(13): 3577-81. PMID: 1617627, ISSN: 0008-5472.

Okamura T, Garland EM, Johnson LS, Cano M, Johansson SL, Cohen SM. Acute urinary tract toxicity of tetraethylorthosilicate in rats. Fundam Appl Toxicol. 1992 Apr; 18(3): 425-41. PMID: 1597267, ISSN: 0272-0590.

Cohen SM, Garland EM, Ellwein LB. Cancer enhancement by cell proliferation. Prog. Clin. Biol. Res. 1992; 374: 213-29. PMID: 1620705, ISSN: 0361-7742.

Garland EM, Shapiro R, Kraft PL, Mattson BJ, Parr JM, Cohen SM. Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. II. Dose response and reversibility. Food Chem. Toxicol. 1991 Oct; 29(10): 669-79. PMID: 1959820, ISSN: 0278-6915.

Garland EM, Kraft PL, Shapiro R, Khachab M, Patil K, Ellwein LB, Cohen SM. Effects of in utero and postnatal sodium saccharin exposure on the nutritional status of the young rat. I. Effects at 30 days post-birth. Food Chem. Toxicol. 1991 Oct; 29(10): 657-67. PMID: 1959819, ISSN: 0278-6915.

Masui T, Mann AM, Macatee TL, Garland EM, Okamura T, Smith RA, Cohen SM. Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea. Carcinogenesis. 1991 Oct; 12(10): 1975-8. PMID: 1682063, ISSN: 0143-3334.

Cohen SM, Cano M, Earl RA, Carson SD, Garland EM. A proposed role for silicates and protein in the proliferative effects of saccharin on the male rat urothelium. Carcinogenesis. 1991 Sep; 12(9): 1551-5. PMID: 1893514, ISSN: 0143-3334.

Masui T, Mann AM, Macatee TL, Okamura T, Garland EM, Fujii H, Pelling JC, Cohen SM. H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts. Cancer Res. 1991 Jul 7/1/1991; 51(13): 3471-5. PMID: 2054786, ISSN: 0008-5472.

Okamura T, Garland EM, Masui T, Sakata T, St John M, Cohen SM. Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet. Cancer Res. 1991 Apr 4/1/1991; 51(7): 1778-82. PMID: 2004361, ISSN: 0008-5472.

Masui T, Garland EM, Wang CY, Cohen SM. Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach. Food Chem. Toxicol. 1990 Jul; 28(7): 497-505. PMID: 2210522, ISSN: 0278-6915.

Cohen SM, Fisher MJ, Sakata T, Cano M, Schoenig GP, Chappel CI, Garland EM. Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography. Scanning Microsc. 1990 Mar; 4(1): 135-42. PMID: 2367830, ISSN: 0891-7035.

Masui T, Mann AM, Garland EM, Okamura T, Johansson PL, Cohen SM. Point mutation in codons 12 and 61 of the Ha-ras gene in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Mol. Carcinog. 1990; 3(4): 210-5. PMID: 2206284, ISSN: 0899-1987.

Masui T, Mann AM, Garland EM, Cohen SM. Strong promoting activity by uracil on urinary bladder carcinogenesis and a possible inhibitory effect on thyroid tumorigenesis in rats initiated with N-methyl-N-nitrosourea. Carcinogenesis. 1989 Aug; 10(8): 1471-4. PMID: 2752521, ISSN: 0143-3334.

Garland EM, Sakata T, Fisher MJ, Masui T, Cohen SM. Influences of diet and strain on the proliferative effect on the rat urinary bladder induced by sodium saccharin. Cancer Res. 1989 Jul 7/15/1989; 49(14): 3789-94. PMID: 2736520, ISSN: 0008-5472.

Sakata T, Smith RA, Garland EM, Cohen SM. Rat urinary bladder epithelial lesions induced by acrolein. J. Environ. Pathol. Toxicol. Oncol. 1989 Mar; 9(2): 159-69. PMID: 2732910, ISSN: 0731-8898.