Abbes Belkhiri, Ph.D.

Assistant Professor

abbes.belkhiri@vanderbilt.edu
Faculty Appointments
Assistant Professor of Surgery
Education
Ph.D., Microbiology, University of Manitoba, Winnipeg, CanadaM.Phil., Philosophy, University of Reading, Reading, United Kingdom
Office Address
D-4314 MCN
760 PRB
2220 Pierce Avenue
Nashville, TN 37232-6308
Publications
Belkhiri A, El-Rifai W. 5-Methylcytosine hydroxylation-mediated LINE-1 hypomethylation: a novel mechanism of proto-oncogenes activation in colorectal cancer?. Gut [print-electronic]. 2014 Apr; 63(4): 538-9. PMID: 23812322, PMCID: PMC4035300, PII: gutjnl-2013-305176, DOI: 10.1136/gutjnl-2013-305176, ISSN: 1468-3288.

Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, Ecsedy J, Belkhiri A, El-Rifai W. Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology [print-electronic]. 2013 Dec; 145(6): 1312-22.e1. PMID: 23993973, PMCID: PMC3840093, PII: S0016-5085(13)01270-5, DOI: 10.1053/j.gastro.2013.08.050, ISSN: 1528-0012.

Hong J, Belkhiri A. AXL mediates TRAIL resistance in esophageal adenocarcinoma. Neoplasia. 2013 Mar; 15(3): 296-304. PMID: 23479507, PMCID: PMC3593152, ISSN: 1476-5586.

Sehdev V, Katsha A, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. The combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas. Cancer [print-electronic]. 2013 Feb 2/15/2013; 119(4): 904-14. PMID: 22972611, PMCID: PMC3524359, DOI: 10.1002/cncr.27801, ISSN: 1097-0142.

Saad R, Chen Z, Zhu S, Jia P, Zhao Z, Washington MK, Belkhiri A, El-Rifai W. Deciphering the unique microRNA signature in human esophageal adenocarcinoma. PLoS ONE [electronic-print]. 2013; 8(5): e64463. PMID: 23724052, PMCID: PMC3665888, PII: PONE-D-12-35460, DOI: 10.1371/journal.pone.0064463, ISSN: 1932-6203.

Zhu S, Hong J, Tripathi MK, Sehdev V, Belkhiri A, El-Rifai W. Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells. Mol. Cancer Res [print-electronic]. 2013 Jan; 11(1): 86-94. PMID: 23160836, PMCID: PMC3552044, PII: 1541-7786.MCR-12-0243-T, DOI: 10.1158/1541-7786.MCR-12-0243-T, ISSN: 1557-3125.

Hong J, Peng D, Chen Z, Sehdev V, Belkhiri A. ABL regulation by AXL promotes cisplatin resistance in esophageal cancer. Cancer Res [print-electronic]. 2013 Jan 1/1/2013; 73(1): 331-40. PMID: 23117882, PII: 0008-5472.CAN-12-3151, DOI: 10.1158/0008-5472.CAN-12-3151, ISSN: 1538-7445.

Hong J, Katsha A, Lu P, Shyr Y, Belkhiri A, El-Rifai W. Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma. Cancer Res [print-electronic]. 2012 Sep 9/1/2012; 72(17): 4504-14. PMID: 22745369, PMCID: PMC3432752, PII: 0008-5472.CAN-12-1119, DOI: 10.1158/0008-5472.CAN-12-1119, ISSN: 1538-7445.

Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut [print-electronic]. 2012 Sep; 61(9): 1250-60. PMID: 22157330, PMCID: PMC3419307, PII: gutjnl-2011-301078, DOI: 10.1136/gutjnl-2011-301078, ISSN: 1468-3288.

Belkhiri A, Zhu S, Chen Z, Soutto M, El-Rifai W. Resistance to TRAIL is mediated by DARPP-32 in gastric cancer. Clin. Cancer Res [print-electronic]. 2012 Jul 7/15/2012; 18(14): 3889-900. PMID: 22589394, PMCID: PMC3399047, PII: 1078-0432.CCR-11-3182, DOI: 10.1158/1078-0432.CCR-11-3182, ISSN: 1078-0432.

Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, Zaika A, Rau TT, Schneider-Stock R, Belkhiri A, El-Rifai W. The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells. Mol. Cancer Ther [print-electronic]. 2012 Mar; 11(3): 763-74. PMID: 22302096, PMCID: PMC3297687, PII: 1535-7163.MCT-11-0623, DOI: 10.1158/1535-7163.MCT-11-0623, ISSN: 1538-8514.

Zhu S, Belkhiri A, El-Rifai W. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. Gastroenterology [print-electronic]. 2011 Nov; 141(5): 1738-48.e1. PMID: 21741919, PMCID: PMC3202055, PII: S0016-5085(11)00920-6, DOI: 10.1053/j.gastro.2011.06.070, ISSN: 1528-0012.

Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM, El-Rifai W. Loss of TFF1 is associated with activation of NF-¿B-mediated inflammation and gastric neoplasia in mice and humans. J. Clin. Invest [print-electronic]. 2011 May; 121(5): 1753-67. PMID: 21490402, PMCID: PMC3083788, PII: 43922, DOI: 10.1172/JCI43922, ISSN: 1558-8238.

Vangamudi B, Zhu S, Soutto M, Belkhiri A, El-Rifai W. Regulation of ß-catenin by t-DARPP in upper gastrointestinal cancer cells. Mol. Cancer. 2011; 10: 32. PMID: 21447180, PMCID: PMC3075216, PII: 1476-4598-10-32, DOI: 10.1186/1476-4598-10-32, ISSN: 1476-4598.

Mukherjee K, Peng D, Brifkani Z, Belkhiri A, Pera M, Koyama T, Koehler EA, Revetta FL, Washington MK, El-Rifai W. Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery [print-electronic]. 2010 Aug; 148(2): 354-63. PMID: 20580047, PMCID: PMC2919779, PII: S0039-6060(10)00274-6, DOI: 10.1016/j.surg.2010.05.011, ISSN: 1532-7361.

Vangamudi B, Peng DF, Cai Q, El-Rifai W, Zheng W, Belkhiri A. T-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer. Mol. Cancer. 2010; 9: 240. PMID: 20836878, PMCID: PMC2945963, PII: 1476-4598-9-240, DOI: 10.1186/1476-4598-9-240, ISSN: 1476-4598.

Dar AA, Belkhiri A, El-Rifai W. The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene [print-electronic]. 2009 Feb 2/12/2009; 28(6): 866-75. PMID: 19060929, PMCID: PMC2642527, PII: onc2008434, DOI: 10.1038/onc.2008.434, ISSN: 1476-5594.

Dar AA, Belkhiri A, Ecsedy J, Zaika A, El-Rifai W. Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells. Cancer Res. 2008 Nov 11/1/2008; 68(21): 8998-9004. PMID: 18974145, PMCID: PMC2587495, PII: 68/21/8998, DOI: 10.1158/0008-5472.CAN-08-2658, ISSN: 1538-7445.

Belkhiri A, Dar AA, Peng DF, Razvi MH, Rinehart C, Arteaga CL, El-Rifai W. Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. Clin. Cancer Res [print-electronic]. 2008 Jul 7/15/2008; 14(14): 4564-71. PMID: 18579663, PMCID: PMC2842884, PII: 1078-0432.CCR-08-0121, DOI: 10.1158/1078-0432.CCR-08-0121, ISSN: 1078-0432.

Dar AA, Zaika A, Piazuelo MB, Correa P, Koyama T, Belkhiri A, Washington K, Castells A, Pera M, El-Rifai W. Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer. 2008 Apr 4/15/2008; 112(8): 1688-98. PMID: 18311783, PMCID: PMC4030394, DOI: 10.1002/cncr.23371, ISSN: 0008-543X.

Available Postdoctoral Position Details
Posted: 2/7/2019

An immediate opening for a postdoctoral position exists at the department of surgery, division of surgical oncology (Vanderbilt University Medical Center). The project is to examine the role of AXL in esophageal tumorigenesis and drug resistance using in vitro cell models and tumor xenograft mice. Individuals with experience in mouse models, cancer biology techniques that include immunoblotting, cell culture, Real-Time PCR, immunofluorescence, recombinant DNA technology, fluorescence microscopy, and flow cytometry are encouraged to apply. The Belkhiri lab offers an interdisciplinary environment with training opportunities in cancer biology. Those interested should contact Dr. Abbes Belkhiri at abbes.belkhiri@vanderbilt.edu