Fiona E. Harrison, Ph.D.

Associate Professor

Visit Lab Site

Faculty Appointments
Associate Professor of Medicine
Ph.D., Behavioral Neuroscience/Psychology, Cardiff University, Cardiff, United KingdomB.Sc., Psychology, Cardiff University, Cardiff, United Kingdom
Office Address
7465 MRBIV
2213 Garland Avenue
Nashville, TN 37232-0475
Research Description
Work in the Harrison lab is focused on understanding how nutrition, illness and environmental exposures impact brain health. Most of our work related to aging and Alzheimer's disease. We use a wide variety of in vivo, ex vivo and in vitro approaches to study key mechanisms including glutamate homeostasis and neuroinflammation.
Research Keywords
Antioxidants, vitamin C, oxidative stress, animal behavior, learning and memory, obesity, Alzheimer's disease, neuroscience, manganese, sepsis, delirium, neuroinflammation, traumatic brain injury
Consoli DC, Spitznagel BD, Owen BM, Kang H, Williams Roberson S, Pandharipande P, Wesley Ely E, Nobis WP, Bastarache JA, Harrison FE. Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis. Brain Behav Immun [print-electronic]. 2022 Oct 10/13/2022; 107: 165-78. PMID: 36243287, PII: S0889-1591(22)00408-1, DOI: 10.1016/j.bbi.2022.10.003, ISSN: 1090-2139.

Chen HY, Almonte-Loya A, Lay FY, Hsu M, Johnson E, González-Avalos E, Yin J, Bruno RS, Ma Q, Ghoneim HE, Wozniak DJ, Harrison FE, Lio CJ. Epigenetic remodeling by vitamin C potentiates plasma cell differentiation. Elife. 2022 Sep 9/7/2022; 11: PMID: 36069787, PMCID: PMC9451539, PII: 73754, DOI: 10.7554/eLife.73754, ISSN: 2050-084X.

Kim H, Harrison FE, Aschner M, Bowman AB. Exposing the role of metals in neurological disorders: a focus on manganese. Trends Mol Med [print-electronic]. 2022 Jul; 28(7): 555-68. PMID: 35610122, PMCID: PMC9233117, PII: S1471-4914(22)00107-1, DOI: 10.1016/j.molmed.2022.04.011, ISSN: 1471-499X.

Whitmore CA, Haynes JR, Behof WJ, Rosenberg AJ, Tantawy MN, Hachey BC, Wadzinski BE, Spiller BW, Peterson TE, Paffenroth KC, Harrison FE, Beelman RB, Wijesinghe P, Matsubara JA, Pham W. Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2022 Jun 6/13/2022; 15(6): PMID: 35745661, PMCID: PMC9228400, PII: ph15060742, DOI: 10.3390/ph15060742, ISSN: 1424-8247.

Behof WJ, Whitmore CA, Haynes JR, Rosenberg AJ, Tantawy MN, Peterson TE, Harrison FE, Beelman RB, Wijesinghe P, Matsubara JA, Pham W. Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer's disease. FEBS Lett [print-electronic]. 2022 May; 596(10): 1279-89. PMID: 35100442, PMCID: PMC9167250, DOI: 10.1002/1873-3468.14303, ISSN: 1873-3468.

Wilcox JM, Consoli DC, Paffenroth KC, Spitznagel BD, Calipari ES, Bowman AB, Harrison FE. Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype. Pharmacol Biochem Behav [print-electronic]. 2022 Feb; 213: 173337. PMID: 35063467, PMCID: PMC8833139, PII: S0091-3057(22)00016-8, DOI: 10.1016/j.pbb.2022.173337, ISSN: 1873-5177.

Meinke C, Quinlan MA, Paffenroth KC, Harrison FE, Fenollar-Ferrer C, Katamish RM, Stillman I, Ramamoorthy S, Blakely RD. Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo. Neurochem Res [print-electronic]. 2022 Jan; 47(1): 37-60. PMID: 33830406, PII: 10.1007/s11064-021-03299-w, DOI: 10.1007/s11064-021-03299-w, ISSN: 1573-6903.

Wilcox JM, Pfalzer AC, Tienda AA, Debbiche IF, Cox EC, Totten MS, Erikson KM, Harrison FE, Bowman AB. YAC128 mouse model of Huntington disease is protected against subtle chronic manganese (Mn)-induced behavioral and neuropathological changes. Neurotoxicology [print-electronic]. 2021 Dec; 87: 94-105. PMID: 34543681, PMCID: PMC8761387, PII: S0161-813X(21)00114-5, DOI: 10.1016/j.neuro.2021.09.002, ISSN: 1872-9711.

Wilcox JM, Consoli DC, Tienda AA, Dixit S, Buchanan RA, May JM, Nobis WP, Harrison FE. Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice. Neurobiol Dis [print-electronic]. 2021 Oct; 158: 105486. PMID: 34450329, PMCID: PMC8457528, PII: S0969-9961(21)00235-7, DOI: 10.1016/j.nbd.2021.105486, ISSN: 1095-953X.

Behof WJ, Whitmore CA, Haynes JR, Rosenberg AJ, Tantawy MN, Peterson TE, Harrison FE, Beelman RB, Pham W. A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications. Sci Rep. 2021 Sep 9/16/2021; 11(1): 18450. PMID: 34531467, PMCID: PMC8446031, PII: 10.1038/s41598-021-97925-w, DOI: 10.1038/s41598-021-97925-w, ISSN: 2045-2322.

Taylor AL, Davis DE, Codreanu SG, Harrison FE, Sherrod SD, McLean JA. Targeted and Untargeted Mass Spectrometry Reveals the Impact of High-Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer's Disease. J Proteome Res [print-electronic]. 2021 Sep 9/3/2021; 20(9): 4405-14. PMID: 34382806, DOI: 10.1021/acs.jproteome.1c00344, ISSN: 1535-3907.

Consoli DC, Brady LJ, Bowman AB, Calipari ES, Harrison FE. Ascorbate deficiency decreases dopamine release in gulo-/- and APP/PSEN1 mice. J Neurochem [print-electronic]. 2021 May; 157(3): 656-65. PMID: 32797675, PMCID: PMC7882008, DOI: 10.1111/jnc.15151, ISSN: 1471-4159.

Ikeda K, Tienda AA, Harrison FE, Kawakami K. Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders. PLoS One. 2021; 16(2): e0246678. PMID: 33544780, PMCID: PMC7864419, PII: PONE-D-20-29560, DOI: 10.1371/journal.pone.0246678, ISSN: 1932-6203.

DiCarlo GE, Mabry SJ, Cao X, McMillan C, Woynaroski TG, Harrison FE, Reddy IA, Matthies HJG, Flynn CR, Wallace MT, Wu H, Galli A. Autism-Associated Variant in the SLC6A3 Gene Alters the Oral Microbiome and Metabolism in a Murine Model. Front Psychiatry. 2021; 12: 655451. PMID: 33935841, PMCID: PMC8081952, DOI: 10.3389/fpsyt.2021.655451, ISSN: 1664-0640.

Oatess TL, Harrison FE, Himmel LE, Jones CP. Effects of Acrylic Tunnel Enrichment on Anxiety-Like Behavior, Neurogenesis, and Physiology of C57BL/6J Mice. J Am Assoc Lab Anim Sci [print-electronic]. 2021 Jan 1/1/2021; 60(1): 44-53. PMID: 33008490, PMCID: PMC7831345, DOI: 10.30802/AALAS-JAALAS-19-000159, ISSN: 2769-6677.

Pfalzer AC, Wilcox JM, Codreanu SG, Totten M, Bichell TJV, Halbesma T, Umashanker P, Yang KL, Parmalee NL, Sherrod SD, Erikson KM, Harrison FE, McLean JA, Aschner M, Bowman AB. Huntington's disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice. Metallomics. 2020 Jul 7/22/2020; 12(7): 1118-30. PMID: 32421118, PMCID: PMC7773276, DOI: 10.1039/d0mt00081g, ISSN: 1756-591X.

Fan X, Sell DR, Hao C, Liu S, Wang B, Wesson DW, Siedlak S, Zhu X, Kavanagh TJ, Harrison FE, Monnier VM. Vitamin C is a source of oxoaldehyde and glycative stress in age-related cataract and neurodegenerative diseases. Aging Cell [print-electronic]. 2020 Jul; 19(7): e13176. PMID: 32567221, PMCID: PMC7418511, DOI: 10.1111/acel.13176, ISSN: 1474-9726.

Balachandran RC, Mukhopadhyay S, McBride D, Veevers J, Harrison FE, Aschner M, Haynes EN, Bowman AB. Brain manganese and the balance between essential roles and neurotoxicity. J Biol Chem [print-electronic]. 2020 May 5/8/2020; 295(19): 6312-29. PMID: 32188696, PMCID: PMC7212623, PII: S0021-9258(17)48498-5, DOI: 10.1074/jbc.REV119.009453, ISSN: 1083-351X.

Consoli DC, Jesse JJ, Klimo KR, Tienda AA, Putz ND, Bastarache JA, Harrison FE. A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain. Nutrients. 2020 Mar 3/26/2020; 12(4): PMID: 32224930, PMCID: PMC7231213, PII: nu12040911, DOI: 10.3390/nu12040911, ISSN: 2072-6643.

Crawley JN, Fagiolini M, Harrison FE, Samaco R, Wozniak DF, Robinson MB. Behavioral analyses of animal models of intellectual and developmental disabilities [editorial]. Neurobiol Learn Mem [print-electronic]. 2019 Nov; 165: 107087. PMID: 31499164, PII: S1074-7427(19)30154-6, DOI: 10.1016/j.nlm.2019.107087, ISSN: 1095-9564.

Shaver CM, Paul MG, Putz ND, Landstreet SR, Kuck JL, Scarfe L, Skrypnyk N, Yang H, Harrison FE, de Caestecker MP, Bastarache JA, Ware LB. Cell-free hemoglobin augments acute kidney injury during experimental sepsis. Am J Physiol Renal Physiol [print-electronic]. 2019 Oct 10/1/2019; 317(4): F922-F929. PMID: 31364379, PMCID: PMC6843044, DOI: 10.1152/ajprenal.00375.2018, ISSN: 1522-1466.

Martins AC, Morcillo P, Ijomone OM, Venkataramani V, Harrison FE, Lee E, Bowman AB, Aschner M. New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease. Int J Environ Res Public Health. 2019 Sep 9/22/2019; 16(19): PMID: 31546716, PMCID: PMC6801377, PII: ijerph16193546, DOI: 10.3390/ijerph16193546, ISSN: 1660-4601.

Shoemaker AH, Paffenroth KC, Bingham N, Harrison FE. Impaired amygdala-based learning and decreased anxiety in a murine model of pseudohypoparathyroidism type 1A. Behav Brain Res [print-electronic]. 2019 Jul 7/23/2019; 367: 53-8. PMID: 30922937, PMCID: PMC6476654, PII: S0166-4328(18)31537-7, DOI: 10.1016/j.bbr.2019.03.041, ISSN: 1872-7549.

DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A. Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. J Clin Invest. 2019 May 5/16/2019; 129(8): 3407-19. PMID: 31094705, PMCID: PMC6668686, PII: 127411, DOI: 10.1172/JCI127411, ISSN: 1558-8238.

Mi DJ, Dixit S, Warner TA, Kennard JA, Scharf DA, Kessler ES, Moore LM, Consoli DC, Bown CW, Eugene AJ, Kang JQ, Harrison FE. Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice. Neurobiol Aging [print-electronic]. 2018 Nov; 71: 241-54. PMID: 30172223, PMCID: PMC6162152, PII: S0197-4580(18)30285-9, DOI: 10.1016/j.neurobiolaging.2018.08.002, ISSN: 1558-1497.

Bernardo-Colón A, Vest V, Clark A, Cooper ML, Calkins DJ, Harrison FE, Rex TS. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. 2018 Oct 10/26/2018; 9(11): 1097. PMID: 30367086, PMCID: PMC6203845, PII: 10.1038/s41419-018-1061-4, DOI: 10.1038/s41419-018-1061-4, ISSN: 2041-4889.

Eckman J, Dixit S, Nackenoff A, Schrag M, Harrison FE. Oxidative Stress Levels in the Brain Are Determined by Post-Mortem Interval and Ante-Mortem Vitamin C State but Not Alzheimer's Disease Status. Nutrients. 2018 Jul 7/9/2018; 10(7): PMID: 29987201, PMCID: PMC6073320, PII: nu10070883, DOI: 10.3390/nu10070883, ISSN: 2072-6643.

Yu H, Harrison FE, Xia F. Altered DNA repair; an early pathogenic pathway in Alzheimer's disease and obesity. Sci Rep. 2018 Apr 4/4/2018; 8(1): 5600. PMID: 29618789, PMCID: PMC5884847, PII: 10.1038/s41598-018-23644-4, DOI: 10.1038/s41598-018-23644-4, ISSN: 2045-2322.

Zabel M, Nackenoff A, Kirsch WM, Harrison FE, Perry G, Schrag M. Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens. Free Radic Biol Med [print-electronic]. 2018 Feb 2/1/2018; 115: 351-60. PMID: 29253591, PMCID: PMC6435270, PII: S0891-5849(17)31263-7, DOI: 10.1016/j.freeradbiomed.2017.12.016, ISSN: 1873-4596.

Dixit S, Fessel JP, Harrison FE. Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Free Radic Biol Med [print-electronic]. 2017 Nov; 112: 515-23. PMID: 28863942, PMCID: PMC5623070, PII: S0891-5849(17)30737-2, DOI: 10.1016/j.freeradbiomed.2017.08.021, ISSN: 1873-4596.

Walker JM, Dixit S, Saulsberry AC, May JM, Harrison FE. Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, ß-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease. Neurobiol. Dis [print-electronic]. 2017 Apr; 100: 87-98. PMID: 28108292, PMCID: PMC5316363, PII: S0969-9961(17)30013-X, DOI: 10.1016/j.nbd.2017.01.004, ISSN: 1095-953X.

Sharif NF, Korade Z, Porter NA, Harrison FE. Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome. Genes Brain Behav [print-electronic]. 2017 Feb 2/21/2017; PMID: 28220990, DOI: 10.1111/gbb.12376, ISSN: 1601-183X.

Walker JM, Harrison FE. Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer's Disease: Impacts on Cognitive Decline. Nutrients. 2015 Sep; 7(9): 7332-57. PMID: 26340637, PMCID: PMC4586536, PII: nu7095341, DOI: 10.3390/nu7095341, ISSN: 2072-6643.

Rao SK, Ross JM, Harrison FE, Bernardo A, Reiserer RS, Reiserer RS, Mobley JA, McDonald MP. Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics. Neurobiol. Dis [print-electronic]. 2015 Jun; 78: 45-55. PMID: 25818006, PMCID: PMC4426078, PII: S0969-9961(15)00090-X, DOI: 10.1016/j.nbd.2015.03.018, ISSN: 1095-953X.

Perez K, Hailey CJ, Bauer FE, Krivonos RA, Mori K, Baganoff FK, Barrière NM, Boggs SE, Christensen FE, Craig WW, Grefenstette BW, Grindlay JE, Harrison FA, Hong J, Madsen KK, Nynka M, Stern D, Tomsick JA, Wik DR, Zhang S, Zhang WW, Zoglauer A. Extended hard-X-ray emission in the inner few parsecs of the Galaxy. Nature. 2015 Apr 4/30/2015; 520(7549): 646-9. PMID: 25925477, PII: nature14353, DOI: 10.1038/nature14353, ISSN: 1476-4687.

Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE. Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. ACS Chem Neurosci [print-electronic]. 2015 Apr 4/15/2015; 6(4): 570-81. PMID: 25642732, PMCID: PMC4476071, DOI: 10.1021/cn500308h, ISSN: 1948-7193.

He XB, Kim M, Kim SY, Yi SH, Rhee YH, Kim T, Lee EH, Park CH, Dixit S, Harrison FE, Lee SH. Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner. Stem Cells. 2015 Apr; 33(4): 1320-32. PMID: 25535150, PMCID: PMC4435601, DOI: 10.1002/stem.1932, ISSN: 1549-4918.

Warner TA, Kang JQ, Kennard JA, Harrison FE. Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. Epilepsy Res [print-electronic]. 2015 Feb; 110: 20-5. PMID: 25616451, PMCID: PMC4306812, PII: S0920-1211(14)00333-7, DOI: 10.1016/j.eplepsyres.2014.11.017, ISSN: 1872-6844.

Kennard JA, Harrison FE. Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Behav. Brain Res [print-electronic]. 2014 May 5/1/2014; 264: 34-42. PMID: 24508240, PMCID: PMC3980584, PII: S0166-4328(14)00058-8, DOI: 10.1016/j.bbr.2014.01.044, ISSN: 1872-7549.

Harrison FE, Bowman GL, Polidori MC. Ascorbic acid and the brain: rationale for the use against cognitive decline. Nutrients. 2014 Apr; 6(4): 1752-81. PMID: 24763117, PMCID: PMC4011065, PII: nu6041752, DOI: 10.3390/nu6041752, ISSN: 2072-6643.

Korade Z, Xu L, Harrison FE, Ahsen R, Hart SE, Folkes OM, Mirnics K, Porter NA. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. Biol. Psychiatry [print-electronic]. 2014 Feb 2/1/2014; 75(3): 215-22. PMID: 23896203, PMCID: PMC3874268, PII: S0006-3223(13)00591-X, DOI: 10.1016/j.biopsych.2013.06.013, ISSN: 1873-2402.

May JM, Harrison FE. Role of vitamin C in the function of the vascular endothelium. Antioxid. Redox Signal [print-electronic]. 2013 Dec 12/10/2013; 19(17): 2068-83. PMID: 23581713, PMCID: PMC3869438, DOI: 10.1089/ars.2013.5205, ISSN: 1557-7716.

Pierce MR, Diasio DL, Rodrigues LM, Harrison FE, May JM. Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice. Nutr Neurosci [print-electronic]. 2013 Jul; 16(4): 160-73. PMID: 23321552, PMCID: PMC3869026, PII: nns109, DOI: 10.1179/1476830512Y.0000000042, ISSN: 1476-8305.

Korade Z, Folkes OM, Harrison FE. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith-Lemli-Opitz syndrome. Pharmacol. Biochem. Behav [print-electronic]. 2013 May; 106: 101-8. PMID: 23541496, PII: S0091-3057(13)00073-7, DOI: 10.1016/j.pbb.2013.03.007, ISSN: 1873-5177.

Ward MS, Lamb J, May JM, Harrison FE. Behavioral and monoamine changes following severe vitamin C deficiency. J. Neurochem [print-electronic]. 2013 Feb; 124(3): 363-75. PMID: 23106783, PMCID: PMC3540126, DOI: 10.1111/jnc.12069, ISSN: 1471-4159.

Jiang H, Harrison FE, Jain K, Benjamin S, May JM, Graves JP, Zeldin DC, Falck JR, Hammock BD, McGiff JC. Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. Adv Biosci Biotechnol. 2012 Jun 6/1/2012; 3(3): 204-18. PMID: 24660109, PMCID: PMC3958942, DOI: 10.4236/abb.2012.33029, ISSN: 2156-8456.

Harrison FE. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J. Alzheimers Dis. 2012; 29(4): 711-26. PMID: 22366772, PMCID: PMC3727637, PII: M21212452440570L, DOI: 10.3233/JAD-2012-111853, ISSN: 1875-8908.

Harrison FE, Best JL, Meredith ME, Gamlin CR, Borza DB, May JM. Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung. PLoS ONE [print-electronic]. 2012; 7(4): e35623. PMID: 22558179, PMCID: PMC3340390, PII: PONE-D-12-05229, DOI: 10.1371/journal.pone.0035623, ISSN: 1932-6203.

Meredith ME, Harrison FE, May JM. Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem. Biophys. Res. Commun [print-electronic]. 2011 Nov 11/4/2011; 414(4): 737-42. PMID: 22001929, PMCID: PMC3210393, PII: S0006-291X(11)01774-8, DOI: 10.1016/j.bbrc.2011.09.146, ISSN: 1090-2104.

Harrison F, Hailey CJ. X-ray vision. Sci. Am. 2011 Feb; 304(2): 78-9. PMID: 21319546, ISSN: 0036-8733.

Davies SS, Bodine C, Matafonova E, Pantazides BG, Bernoud-Hubac N, Harrison FE, Olson SJ, Montine TJ, Amarnath V, Roberts LJ. Treatment with a ¿-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J. Alzheimers Dis. 2011; 27(1): 49-59. PMID: 21709376, PMCID: PMC3289064, PII: P6Q787755RMQ5530, DOI: 10.3233/JAD-2011-102118, ISSN: 1875-8908.

Harrison FE, Dawes SM, Meredith ME, Babaev VR, Li L, May JM. Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic. Biol. Med [print-electronic]. 2010 Sep 9/1/2010; 49(5): 821-9. PMID: 20541602, PMCID: PMC2916678, PII: S0891-5849(10)00360-6, DOI: 10.1016/j.freeradbiomed.2010.06.008, ISSN: 1873-4596.

Harrison FE, Meredith ME, Dawes SM, Saskowski JL, May JM. Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development. Brain Res [print-electronic]. 2010 Aug 8/19/2010; 1349: 143-52. PMID: 20599829, PMCID: PMC2914834, PII: S0006-8993(10)01401-0, DOI: 10.1016/j.brainres.2010.06.037, ISSN: 1872-6240.

Harrison FE, Green RJ, Dawes SM, May JM. Vitamin C distribution and retention in the mouse brain. Brain Res [print-electronic]. 2010 Aug 8/12/2010; 1348: 181-6. PMID: 20570663, PMCID: PMC2912448, PII: S0006-8993(10)01294-1, DOI: 10.1016/j.brainres.2010.05.090, ISSN: 1872-6240.

Harrison FE, May JM, McDonald MP. Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Pharmacol. Biochem. Behav [print-electronic]. 2010 Feb; 94(4): 543-52. PMID: 19941887, PMCID: PMC2828687, PII: S0091-3057(09)00320-7, DOI: 10.1016/j.pbb.2009.11.009, ISSN: 1873-5177.

Harrison FE, Hosseini AH, Dawes SM, Weaver S, May JM. Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze. Behav. Brain Res [print-electronic]. 2009 Dec 12/28/2009; 205(2): 550-8. PMID: 19703495, PMCID: PMC2759855, PII: S0166-4328(09)00501-4, DOI: 10.1016/j.bbr.2009.08.017, ISSN: 1872-7549.

Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiol. Aging [print-electronic]. 2009 Nov; 30(11): 1777-91. PMID: 18258340, PII: S0197-4580(07)00498-8, DOI: 10.1016/j.neurobiolaging.2007.12.022, ISSN: 1558-1497.

Harrison FE, Hosseini AH, McDonald MP, May JM. Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacol. Biochem. Behav [print-electronic]. 2009 Oct; 93(4): 443-50. PMID: 19539642, PMCID: PMC2725435, PII: S0091-3057(09)00183-X, DOI: 10.1016/j.pbb.2009.06.006, ISSN: 1873-5177.

Harrison FE, Allard J, Bixler R, Usoh C, Li L, May JM, McDonald MP. Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutr Neurosci. 2009 Oct; 12(5): 203-18. PMID: 19761651, PMCID: PMC3730134, DOI: 10.1179/147683009X423364, ISSN: 1476-8305.

Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic. Biol. Med [print-electronic]. 2009 Mar 3/15/2009; 46(6): 719-30. PMID: 19162177, PMCID: PMC2649700, PII: S0891-5849(09)00002-1, DOI: 10.1016/j.freeradbiomed.2008.12.018, ISSN: 1873-4596.

Harrison FE, Hosseini AH, McDonald MP. Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav. Brain Res [print-electronic]. 2009 Mar 3/2/2009; 198(1): 247-51. PMID: 18996418, PMCID: PMC2663577, PII: S0166-4328(08)00574-3, DOI: 10.1016/j.bbr.2008.10.015, ISSN: 1872-7549.

Harrison FE, Yu SS, Van Den Bossche KL, Li L, May JM, McDonald MP. Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J. Neurochem [print-electronic]. 2008 Aug; 106(3): 1198-208. PMID: 18466336, PMCID: PMC2575028, PII: JNC5469, DOI: 10.1111/j.1471-4159.2008.05469.x, ISSN: 1471-4159.

Reiserer RS, Harrison FE, Syverud DC, McDonald MP. Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav. 2007 Feb; 6(1): 54-65. PMID: 17233641, PII: GBB221, DOI: 10.1111/j.1601-183X.2006.00221.x, ISSN: 1601-1848.

Harrison FE, Reiserer RS, Tomarken AJ, McDonald MP. Spatial and nonspatial escape strategies in the Barnes maze. Learn. Mem [print-electronic]. 2006 Nov; 13(6): 809-19. PMID: 17101874, PMCID: PMC1783636, PII: lm.334306, DOI: 10.1101/lm.334306, ISSN: 1072-0502.

Available Postdoctoral Position Details
Posted: 5/2/2017

The Harrison lab welcomes applications from post doctoral (or final year predoctoral) candidates with interests in early pathogenic changes associated with Alzheimer's disease and related neurodegenerative diseases.

Current projects in the lab include 1) ascorbate deficiency and altered glutamate clearance in seizures,  2) exposure to manganese and other environmental toxins, and 3) impact of critical illness and delirium on later brain function. In both projects the focus is on highlighting pathways that can be targeted by pharmacological or nutritional interventions to prevent or slow cognitive decline.

The ideal candidate will be experienced in a number of different molecular biology techniques already in use in these projects, and may also bring new techniques and experiences to the lab. Our lab is a collaborative group, with many opportunities for students to participate in research. An interest in teaching and mentoring is, therefore, also welcomed. Experience in some of the following is preferred: animal handling and colony maintenance, biochemical determination of oxidative stress, mRNA and protein expression, rodent behavioral testing, EEG, cell culture, immunohistochemistry.

In some cases, an offer may be contingent on securing training grant funding.