Fiona E. Harrison, Ph.D.

Associate Professor

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Faculty Appointments
Associate Professor of Medicine
Ph.D., Behavioral Neuroscience/Psychology, Cardiff University, Cardiff, United KingdomB.Sc., Psychology, Cardiff University, Cardiff, United Kingdom
Office Address
7465 MRBIV
2213 Garland Avenue
Nashville, TN 37232-0475
Research Keywords
Antioxidants, vitamin C, oxidative stress, animal behavior, learning and memory, obesity, Alzheimer's disease, neuroscience
Walker JM, Dixit S, Saulsberry AC, May JM, Harrison FE. Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, ß-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease. Neurobiol. Dis [print-electronic]. 2017 Apr; 100: 87-98. PMID: 28108292, PMCID: PMC5316363, PII: S0969-9961(17)30013-X, DOI: 10.1016/j.nbd.2017.01.004, ISSN: 1095-953X.

Sharif NF, Korade Z, Porter NA, Harrison FE. Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome. Genes Brain Behav [print-electronic]. 2017 Feb 2/21/2017; PMID: 28220990, DOI: 10.1111/gbb.12376, ISSN: 1601-183X.

Walker JM, Harrison FE. Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer's Disease: Impacts on Cognitive Decline. Nutrients. 2015 Sep; 7(9): 7332-57. PMID: 26340637, PMCID: PMC4586536, PII: nu7095341, DOI: 10.3390/nu7095341, ISSN: 2072-6643.

Rao SK, Ross JM, Harrison FE, Bernardo A, Reiserer RS, Reiserer RS, Mobley JA, McDonald MP. Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics. Neurobiol. Dis [print-electronic]. 2015 Jun; 78: 45-55. PMID: 25818006, PMCID: PMC4426078, PII: S0969-9961(15)00090-X, DOI: 10.1016/j.nbd.2015.03.018, ISSN: 1095-953X.

Perez K, Hailey CJ, Bauer FE, Krivonos RA, Mori K, Baganoff FK, Barrière NM, Boggs SE, Christensen FE, Craig WW, Grefenstette BW, Grindlay JE, Harrison FA, Hong J, Madsen KK, Nynka M, Stern D, Tomsick JA, Wik DR, Zhang S, Zhang WW, Zoglauer A. Extended hard-X-ray emission in the inner few parsecs of the Galaxy. Nature. 2015 Apr 4/30/2015; 520(7549): 646-9. PMID: 25925477, PII: nature14353, DOI: 10.1038/nature14353, ISSN: 1476-4687.

Dixit S, Bernardo A, Walker JM, Kennard JA, Kim GY, Kessler ES, Harrison FE. Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. ACS Chem Neurosci [print-electronic]. 2015 Apr 4/15/2015; 6(4): 570-81. PMID: 25642732, PMCID: PMC4476071, DOI: 10.1021/cn500308h, ISSN: 1948-7193.

He XB, Kim M, Kim SY, Yi SH, Rhee YH, Kim T, Lee EH, Park CH, Dixit S, Harrison FE, Lee SH. Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner. Stem Cells. 2015 Apr; 33(4): 1320-32. PMID: 25535150, PMCID: PMC4435601, DOI: 10.1002/stem.1932, ISSN: 1549-4918.

Warner TA, Kang JQ, Kennard JA, Harrison FE. Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. Epilepsy Res [print-electronic]. 2015 Feb; 110: 20-5. PMID: 25616451, PMCID: PMC4306812, PII: S0920-1211(14)00333-7, DOI: 10.1016/j.eplepsyres.2014.11.017, ISSN: 1872-6844.

Kennard JA, Harrison FE. Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Behav. Brain Res [print-electronic]. 2014 May 5/1/2014; 264: 34-42. PMID: 24508240, PMCID: PMC3980584, PII: S0166-4328(14)00058-8, DOI: 10.1016/j.bbr.2014.01.044, ISSN: 1872-7549.

Harrison FE, Bowman GL, Polidori MC. Ascorbic acid and the brain: rationale for the use against cognitive decline. Nutrients. 2014 Apr; 6(4): 1752-81. PMID: 24763117, PMCID: PMC4011065, PII: nu6041752, DOI: 10.3390/nu6041752, ISSN: 2072-6643.

Korade Z, Xu L, Harrison FE, Ahsen R, Hart SE, Folkes OM, Mirnics K, Porter NA. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. Biol. Psychiatry [print-electronic]. 2014 Feb 2/1/2014; 75(3): 215-22. PMID: 23896203, PMCID: PMC3874268, PII: S0006-3223(13)00591-X, DOI: 10.1016/j.biopsych.2013.06.013, ISSN: 1873-2402.

May JM, Harrison FE. Role of vitamin C in the function of the vascular endothelium. Antioxid. Redox Signal [print-electronic]. 2013 Dec 12/10/2013; 19(17): 2068-83. PMID: 23581713, PMCID: PMC3869438, DOI: 10.1089/ars.2013.5205, ISSN: 1557-7716.

Pierce MR, Diasio DL, Rodrigues LM, Harrison FE, May JM. Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice. Nutr Neurosci [print-electronic]. 2013 Jul; 16(4): 160-73. PMID: 23321552, PMCID: PMC3869026, PII: nns109, DOI: 10.1179/1476830512Y.0000000042, ISSN: 1476-8305.

Korade Z, Folkes OM, Harrison FE. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith-Lemli-Opitz syndrome. Pharmacol. Biochem. Behav [print-electronic]. 2013 May; 106: 101-8. PMID: 23541496, PII: S0091-3057(13)00073-7, DOI: 10.1016/j.pbb.2013.03.007, ISSN: 1873-5177.

Ward MS, Lamb J, May JM, Harrison FE. Behavioral and monoamine changes following severe vitamin C deficiency. J. Neurochem [print-electronic]. 2013 Feb; 124(3): 363-75. PMID: 23106783, PMCID: PMC3540126, DOI: 10.1111/jnc.12069, ISSN: 1471-4159.

Jiang H, Harrison FE, Jain K, Benjamin S, May JM, Graves JP, Zeldin DC, Falck JR, Hammock BD, McGiff JC. Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. Adv Biosci Biotechnol. 2012 Jun 6/1/2012; 3(3): 204-18. PMID: 24660109, PMCID: PMC3958942, DOI: 10.4236/abb.2012.33029, ISSN: 2156-8456.

Harrison FE. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J. Alzheimers Dis. 2012; 29(4): 711-26. PMID: 22366772, PMCID: PMC3727637, PII: M21212452440570L, DOI: 10.3233/JAD-2012-111853, ISSN: 1875-8908.

Harrison FE, Best JL, Meredith ME, Gamlin CR, Borza DB, May JM. Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung. PLoS ONE [print-electronic]. 2012; 7(4): e35623. PMID: 22558179, PMCID: PMC3340390, PII: PONE-D-12-05229, DOI: 10.1371/journal.pone.0035623, ISSN: 1932-6203.

Meredith ME, Harrison FE, May JM. Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem. Biophys. Res. Commun [print-electronic]. 2011 Nov 11/4/2011; 414(4): 737-42. PMID: 22001929, PMCID: PMC3210393, PII: S0006-291X(11)01774-8, DOI: 10.1016/j.bbrc.2011.09.146, ISSN: 1090-2104.

Harrison F, Hailey CJ. X-ray vision. Sci. Am. 2011 Feb; 304(2): 78-9. PMID: 21319546, ISSN: 0036-8733.

Davies SS, Bodine C, Matafonova E, Pantazides BG, Bernoud-Hubac N, Harrison FE, Olson SJ, Montine TJ, Amarnath V, Roberts LJ. Treatment with a ¿-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J. Alzheimers Dis. 2011; 27(1): 49-59. PMID: 21709376, PMCID: PMC3289064, PII: P6Q787755RMQ5530, DOI: 10.3233/JAD-2011-102118, ISSN: 1875-8908.

Harrison FE, Dawes SM, Meredith ME, Babaev VR, Li L, May JM. Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic. Biol. Med [print-electronic]. 2010 Sep 9/1/2010; 49(5): 821-9. PMID: 20541602, PMCID: PMC2916678, PII: S0891-5849(10)00360-6, DOI: 10.1016/j.freeradbiomed.2010.06.008, ISSN: 1873-4596.

Harrison FE, Meredith ME, Dawes SM, Saskowski JL, May JM. Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development. Brain Res [print-electronic]. 2010 Aug 8/19/2010; 1349: 143-52. PMID: 20599829, PMCID: PMC2914834, PII: S0006-8993(10)01401-0, DOI: 10.1016/j.brainres.2010.06.037, ISSN: 1872-6240.

Harrison FE, Green RJ, Dawes SM, May JM. Vitamin C distribution and retention in the mouse brain. Brain Res [print-electronic]. 2010 Aug 8/12/2010; 1348: 181-6. PMID: 20570663, PMCID: PMC2912448, PII: S0006-8993(10)01294-1, DOI: 10.1016/j.brainres.2010.05.090, ISSN: 1872-6240.

Harrison FE, May JM, McDonald MP. Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Pharmacol. Biochem. Behav [print-electronic]. 2010 Feb; 94(4): 543-52. PMID: 19941887, PMCID: PMC2828687, PII: S0091-3057(09)00320-7, DOI: 10.1016/j.pbb.2009.11.009, ISSN: 1873-5177.

Harrison FE, Hosseini AH, Dawes SM, Weaver S, May JM. Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze. Behav. Brain Res [print-electronic]. 2009 Dec 12/28/2009; 205(2): 550-8. PMID: 19703495, PMCID: PMC2759855, PII: S0166-4328(09)00501-4, DOI: 10.1016/j.bbr.2009.08.017, ISSN: 1872-7549.

Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiol. Aging [print-electronic]. 2009 Nov; 30(11): 1777-91. PMID: 18258340, PII: S0197-4580(07)00498-8, DOI: 10.1016/j.neurobiolaging.2007.12.022, ISSN: 1558-1497.

Harrison FE, Hosseini AH, McDonald MP, May JM. Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacol. Biochem. Behav [print-electronic]. 2009 Oct; 93(4): 443-50. PMID: 19539642, PMCID: PMC2725435, PII: S0091-3057(09)00183-X, DOI: 10.1016/j.pbb.2009.06.006, ISSN: 1873-5177.

Harrison FE, Allard J, Bixler R, Usoh C, Li L, May JM, McDonald MP. Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutr Neurosci. 2009 Oct; 12(5): 203-18. PMID: 19761651, PMCID: PMC3730134, DOI: 10.1179/147683009X423364, ISSN: 1476-8305.

Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic. Biol. Med [print-electronic]. 2009 Mar 3/15/2009; 46(6): 719-30. PMID: 19162177, PMCID: PMC2649700, PII: S0891-5849(09)00002-1, DOI: 10.1016/j.freeradbiomed.2008.12.018, ISSN: 1873-4596.

Harrison FE, Hosseini AH, McDonald MP. Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav. Brain Res [print-electronic]. 2009 Mar 3/2/2009; 198(1): 247-51. PMID: 18996418, PMCID: PMC2663577, PII: S0166-4328(08)00574-3, DOI: 10.1016/j.bbr.2008.10.015, ISSN: 1872-7549.

Harrison FE, Yu SS, Van Den Bossche KL, Li L, May JM, McDonald MP. Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J. Neurochem [print-electronic]. 2008 Aug; 106(3): 1198-208. PMID: 18466336, PMCID: PMC2575028, PII: JNC5469, DOI: 10.1111/j.1471-4159.2008.05469.x, ISSN: 1471-4159.

Reiserer RS, Harrison FE, Syverud DC, McDonald MP. Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav. 2007 Feb; 6(1): 54-65. PMID: 17233641, PII: GBB221, DOI: 10.1111/j.1601-183X.2006.00221.x, ISSN: 1601-1848.

Harrison FE, Reiserer RS, Tomarken AJ, McDonald MP. Spatial and nonspatial escape strategies in the Barnes maze. Learn. Mem [print-electronic]. 2006 Nov; 13(6): 809-19. PMID: 17101874, PMCID: PMC1783636, PII: lm.334306, DOI: 10.1101/lm.334306, ISSN: 1072-0502.

Available Postdoctoral Position Details
Posted: 5/2/2017

The Harrison lab welcomes applications from post doctoral (or final year predoctoral) candidates with interests in early pathogenic changes associated with Alzheimer's disease and related neurodegenerative diseases.

Current projects in the lab include 1) ascorbate deficiency and altered glutamate clearance in seizures, and 2) obesity-driven neuroinflammatory response. In both projects the focus is on highlighting pathways that can be targeted by pharmacological or nutritional interventions to prevent or slow cognitive decline.

The ideal candidate will be experienced in a number of different molecular biology techniques already in use in these projects, and may also bring new techniques and experiences to the lab. Our lab is a collaborative group, with many opportunities for students to participate in research. An interest in teaching and mentoring is, therefore, also welcomed. Experience in some of the following is preferred: animal handling and colony maintenance, biochemical determination of oxidative stress, mRNA and protein expression, rodent behavioral testing, EEG, cell culture, immunohistochemistry.

In some cases, an offer may be contingent on securing training grant funding.