Joyce Cheung-Flynn, Ph.D.

Research Associate Professor

joyce.cheung-flynn@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Surgery
Education
Ph.D., Molecular and Cellular Biology, Arizona State University, Tempe, ArizonaM.S., Biology, Northern Arizona University , Flagstaff, ArizonaB.S., Northern Arizona University , Flagstaff, Arizona
Office Address
D-5237 MCN
Nashville, TN 2735
Research Keywords
Vascular biology; purinergic receptor; vein graft preservation; intimal hyperplasia
Publications
Sexton KW, Hocking KM, Wise E, Osgood MJ, Cheung-Flynn J, Komalavilas P, Campbell KE, Dattilo JB, Brophy CM. Women in academic surgery: the pipeline is busted. J Surg Educ [print-electronic]. 2012 Jan; 69(1): 84-90. PMID: 22208838, PMCID: PMC3458116, PII: S1931-7204(11)00229-7, DOI: 10.1016/j.jsurg.2011.07.008, ISSN: 1878-7452.

Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, Schmidt MV. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology [print-electronic]. 2012 Jan; 62(1): 332-9. PMID: 21839098, PII: S0028-3908(11)00329-7, DOI: 10.1016/j.neuropharm.2011.07.041, ISSN: 1873-7064.

Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol. Psychiatry [print-electronic]. 2011 Nov 11/15/2011; 70(10): 928-36. PMID: 21907973, PII: S0006-3223(11)00767-0, DOI: 10.1016/j.biopsych.2011.07.023, ISSN: 1873-2402.

Eagle S, Brophy CM, Komalavilas P, Hocking K, Putumbaka G, Osgood M, Sexton K, Leacche M, Cheung-Flynn J. Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function. Am Surg. 2011 Jul; 77(7): 922-8. PMID: 21944360, PMCID: PMC3957273, ISSN: 1555-9823.

Hocking KM, Brophy C, Rizvi SZ, Komalavilas P, Eagle S, Leacche M, Balaguer JM, Cheung-Flynn J. Detrimental effects of mechanical stretch on smooth muscle function in saphenous veins. J. Vasc. Surg [print-electronic]. 2011 Feb; 53(2): 454-60. PMID: 21146345, PMCID: PMC3053010, PII: S0741-5214(10)02184-1, DOI: 10.1016/j.jvs.2010.09.010, ISSN: 1097-6809.

O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS ONE [print-electronic]. 2011; 6(9): e24840. PMID: 21935478, PMCID: PMC3174203, PII: PONE-D-11-12700, DOI: 10.1371/journal.pone.0024840, ISSN: 1932-6203.

Derkach DN, Wadekar SA, Perkins KB, Rousseau E, Dreiza CM, Cheung-Flynn J, Ramos HC, Ugarova TP, Sheller MR. RGD-dependent binding of TP508 to integrin alphavbeta3 mediates cell adhesion and induction of nitric oxide. Thromb. Haemost [print-electronic]. 2010 Jul; 104(1): 172-82. PMID: 20508901, PMCID: PMC4540356, PII: 09-07-0447, DOI: 10.1160/TH09-07-0447, ISSN: 0340-6245.

Flynn CR, Cheung-Flynn J, Smoke CC, Lowry D, Roberson R, Sheller MR, Brophy CM. Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts. J Pharm Sci. 2010 Jul; 99(7): 3100-21. PMID: 20140957, DOI: 10.1002/jps.22087, ISSN: 1520-6017.

Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF, Dey SK. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Oct 10/4/2005; 102(40): 14326-31. PMID: 16176985, PMCID: PMC1242310, PII: 0505775102, DOI: 10.1073/pnas.0505775102, ISSN: 0027-8424.

Cheung-Flynn J, Prapapanich V, Cox MB, Riggs DL, Suarez-Quian C, Smith DF. Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol. Endocrinol [print-electronic]. 2005 Jun; 19(6): 1654-66. PMID: 15831525, PII: me.2005-0071, DOI: 10.1210/me.2005-0071, ISSN: 0888-8809.

Riggs DL, Cox MB, Cheung-Flynn J, Prapapanich V, Carrigan PE, Smith DF. Functional specificity of co-chaperone interactions with Hsp90 client proteins. Crit. Rev. Biochem. Mol. Biol. 2004 Sep; 39(5-6): 279-95. PMID: 15763706, PII: UA72K1EHB3YJ1QEJ, DOI: 10.1080/10409230490892513, ISSN: 1040-9238.

Hubler TR, Denny WB, Valentine DL, Cheung-Flynn J, Smith DF, Scammell JG. The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. Endocrinology. 2003 Jun; 144(6): 2380-7. PMID: 12746298, DOI: 10.1210/en.2003-0092, ISSN: 0013-7227.

Cheung-Flynn J, Roberts PJ, Riggs DL, Smith DF. C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. J. Biol. Chem [print-electronic]. 2003 May 5/9/2003; 278(19): 17388-94. PMID: 12611898, PII: M300955200, DOI: 10.1074/jbc.M300955200, ISSN: 0021-9258.

Riggs DL, Roberts PJ, Chirillo SC, Cheung-Flynn J, Prapapanich V, Ratajczak T, Gaber R, Picard D, Smith DF. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J. 2003 Mar 3/3/2003; 22(5): 1158-67. PMID: 12606580, PMCID: PMC150341, DOI: 10.1093/emboj/cdg108, ISSN: 0261-4189.

Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Feb 2/4/2003; 100(3): 868-73. PMID: 12538866, PMCID: PMC298693, PII: 0231020100, DOI: 10.1073/pnas.0231020100, ISSN: 0027-8424.

Cheung J, Smith DF. Molecular chaperone interactions with steroid receptors: an update. Mol. Endocrinol. 2000 Jul; 14(7): 939-46. PMID: 10894145, DOI: 10.1210/mend.14.7.0489, ISSN: 0888-8809.

Fajardo DA, Cheung J, Ito C, Sugawara E, Nikaido H, Misra R. Biochemistry and regulation of a novel Escherichia coli K-12 porin protein, OmpG, which produces unusually large channels. J. Bacteriol. 1998 Sep; 180(17): 4452-9. PMID: 9721282, PMCID: PMC107454, ISSN: 0021-9193.

Cheung J, Danna KJ, O'Connor EM, Price LB, Shand RF. Isolation, sequence, and expression of the gene encoding halocin H4, a bacteriocin from the halophilic archaeon Haloferax mediterranei R4. J. Bacteriol. 1997 Jan; 179(2): 548-51. PMID: 8990311, PMCID: PMC178729, ISSN: 0021-9193.