Olivier G. Boutaud, Ph.D.

2200 Pierce Avenue
Nashville, TN 37232-6602

Spearing PK, Cho HP, Luscombe VB, Blobaum AL, Boutaud O, Engers DW, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Bender AM. Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M₁. Bioorg Med Chem Lett [print-electronic]. 2021 Sep 9/1/2021; 47: 128193. PMID: 34118412, PMCID: PMC8349895, PII: S0960-894X(21)00420-0, DOI: 10.1016/j.bmcl.2021.128193, ISSN: 1464-3405.

Kent CN, Fulton MG, Stillwell KJ, Dickerson JW, Loch MT, Rodriguez AL, Blobaum AL, Boutaud O, Rook JL, Niswender CM, Conn PJ, Lindsley CW. Discovery and optimization of a novel CNS penetrant series of mGlu₄ PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model. Bioorg Med Chem Lett [print-electronic]. 2021 Apr 4/1/2021; 37: 127838. PMID: 33556572, PII: S0960-894X(21)00064-0, DOI: 10.1016/j.bmcl.2021.127838, ISSN: 1464-3405.

Gobert AP, Boutaud O, Asim M, Zagol-Ikapitte IA, Delgado AG, Latour YL, Finley JL, Singh K, Verriere TG, Allaman MM, Barry DP, McNamara KM, Sierra JC, Amarnath V, Tantawy MN, Bimczok D, Piazuelo MB, Washington MK, Zhao S, Coburn LA, Wilson KT. Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis. Gastroenterology [print-electronic]. 2021 Mar; 160(4): 1256-1268.e9. PMID: 33189701, PMCID: PMC7956217, PII: S0016-5085(20)35394-4, DOI: 10.1053/j.gastro.2020.11.006, ISSN: 1528-0012.

Davis DC, Bungard JD, Chang S, Rodriguez AL, Blobaum AL, Boutaud O, Melancon BJ, Niswender CM, Jeffrey Conn P, Lindsley CW. Lead optimization of the VU0486321 series of mGlu₁ PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs. Bioorg Med Chem Lett [print-electronic]. 2021 Jan 1/15/2021; 32: 127724. PMID: 33253881, PII: S0960-894X(20)30835-0, DOI: 10.1016/j.bmcl.2020.127724, ISSN: 1464-3405.

Dikalova A, Mayorov V, Xiao L, Panov A, Amarnath V, Zagol-Ikapitte I, Vergeade A, Ao M, Yermalitsky V, Nazarewicz RR, Boutaud O, Lopez MG, Billings FT, Davies S, Roberts LJ, Harrison DG, Dikalov S. Mitochondrial Isolevuglandins Contribute to Vascular Oxidative Stress and Mitochondria-Targeted Scavenger of Isolevuglandins Reduces Mitochondrial Dysfunction and Hypertension. Hypertension [print-electronic]. 2020 Dec; 76(6): 1980-91. PMID: 33012204, PMCID: PMC7666054, DOI: 10.1161/HYPERTENSIONAHA.120.15236, ISSN: 1524-4563.

Tao H, Huang J, Yancey PG, Yermalitsky V, Blakemore JL, Zhang Y, Ding L, Zagol-Ikapitte I, Ye F, Amarnath V, Boutaud O, Oates JA, Roberts LJ, Davies SS, Linton MF. Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr^-/- mice. Nat Commun. 2020 Aug 8/14/2020; 11(1): 4084. PMID: 32796843, PMCID: PMC7429830, PII: 10.1038/s41467-020-17915-w, DOI: 10.1038/s41467-020-17915-w, ISSN: 2041-1723.

Prinsen JK, Kannankeril PJ, Sidorova TN, Yermalitskaya LV, Boutaud O, Zagol-Ikapitte I, Barnett JV, Murphy MB, Subati T, Stark JM, Christopher IL, Jafarian-Kerman SR, Saleh MA, Norlander AE, Loperena R, Atkinson JB, Fogo AB, Luther JM, Amarnath V, Davies SS, Kirabo A, Madhur MS, Harrison DG, Murray KT. Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension. JACC Basic Transl Sci. 2020 Jun; 5(6): 602-15. PMID: 32613146, PMCID: PMC7315188, PII: S2452-302X(20)30165-0, DOI: 10.1016/j.jacbts.2020.04.004, ISSN: 2452-302X.

Pitchford LM, Driver PM, Fuller JC, Akers WS, Abumrad NN, Amarnath V, Milne GL, Chen SC, Ye F, Roberts LJ, Shoemaker MB, Oates JA, Rathmacher JA, Boutaud O. Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial. BMC Pharmacol Toxicol. 2020 Jan 1/6/2020; 21(1): 3. PMID: 31907026, PMCID: PMC6945443, PII: 10.1186/s40360-020-0382-y, DOI: 10.1186/s40360-020-0382-y, ISSN: 2050-6511.

Davies SS, May-Zhang LS, Boutaud O, Amarnath V, Kirabo A, Harrison DG. Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions. Pharmacol Ther [print-electronic]. 2020 Jan; 205: 107418. PMID: 31629006, PMCID: PMC7495735, PII: S0163-7258(19)30170-6, DOI: 10.1016/j.pharmthera.2019.107418, ISSN: 1879-016X.

Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A. Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension. Am J Physiol Heart Circ Physiol [print-electronic]. 2019 Mar 3/1/2019; 316(3): H639-H646. PMID: 30608177, PMCID: PMC6459311, DOI: 10.1152/ajpheart.00595.2018, ISSN: 1522-1539.

Pitchford LM, Rathmacher JA, Fuller JC, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O. First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers. BMC Pharmacol Toxicol. 2019 Jan 1/5/2019; 20(1): 1. PMID: 30611293, PMCID: PMC6321651, PII: 10.1186/s40360-018-0281-7, DOI: 10.1186/s40360-018-0281-7, ISSN: 2050-6511.

Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA, Dikalov SI, Zaika AI. Gastroesophageal Reflux Induces Protein Adducts in the Esophagus [letter]. Cell Mol Gastroenterol Hepatol [print-electronic]. 2019; 7(2): 480-482.e7. PMID: 30827415, PMCID: PMC6410348, PII: S2352-345X(18)30163-2, DOI: 10.1016/j.jcmgh.2018.10.017, ISSN: 2352-345X.

Giménez-Bastida JA, Boeglin WE, Boutaud O, Malkowski MG, Schneider C. Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation. FASEB J [print-electronic]. 2019 Jan; 33(1): 1033-41. PMID: 30096040, PMCID: PMC6355089, DOI: 10.1096/fj.201801018R, ISSN: 1530-6860.

Fuller JC, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA. In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate. Food Chem Toxicol [print-electronic]. 2018 Nov; 121: 541-8. PMID: 30253245, PMCID: PMC6220894, PII: S0278-6915(18)30691-4, DOI: 10.1016/j.fct.2018.09.047, ISSN: 1873-6351.

Salisbury-Ruf CT, Bertram CC, Vergeade A, Lark DS, Shi Q, Heberling ML, Fortune NL, Okoye GD, Jerome WG, Wells QS, Fessel J, Moslehi J, Chen H, Roberts LJ, Boutaud O, Gamazon ER, Zinkel SS. Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study. Elife. 2018 Oct 10/3/2018; 7: PMID: 30281024, PMCID: PMC6234033, PII: 40907, DOI: 10.7554/eLife.40907, ISSN: 2050-084X.

Boer RE, Giménez-Bastida JA, Boutaud O, Jana S, Schneider C, Sulikowski GA. Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E₂. Org Lett [print-electronic]. 2018 Jul 7/6/2018; 20(13): 4020-2. PMID: 29916257, PMCID: PMC6425725, DOI: 10.1021/acs.orglett.8b01578, ISSN: 1523-7052.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA. Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis. Cancer Prev Res (Phila) [print-electronic]. 2016 Nov; 9(11): 855-65. PMID: 27554763, PMCID: PMC5093073, PII: 1940-6207.CAPR-16-0094, DOI: 10.1158/1940-6207.CAPR-16-0094, ISSN: 1940-6215.

Woodling NS, Colas D, Wang Q, Minhas P, Panchal M, Liang X, Mhatre SD, Brown H, Ko N, Zagol-Ikapitte I, van der Hart M, Khroyan TV, Chuluun B, Priyam PG, Milne GL, Rassoulpour A, Boutaud O, Manning-Bog AB, Heller HC, Andreasson KI. Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. Brain [print-electronic]. 2016 Jul; 139(Pt 7): 2063-81. PMID: 27190010, PMCID: PMC4939702, PII: aww117, DOI: 10.1093/brain/aww117, ISSN: 1460-2156.

Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O. Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Mitochondrion [print-electronic]. 2016 May; 28: 88-95. PMID: 27085476, PMCID: PMC4860904, PII: S1567-7249(16)30021-6, DOI: 10.1016/j.mito.2016.04.002, ISSN: 1872-8278.

Zagol-Ikapite I, Sosa IR, Oram D, Judd A, Amarnath K, Amarnath V, Stec D, Oates JA, Boutaud O. Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers. J Lipid Res [print-electronic]. 2015 Nov; 56(11): 2196-205. PMID: 26378094, PMCID: PMC4617406, PII: S0022-2275(20)35488-2, DOI: 10.1194/jlr.P063271, ISSN: 1539-7262.

Friedman EA, Ogletree ML, Haddad EV, Boutaud O. Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease. Thromb Res [print-electronic]. 2015 Sep; 136(3): 493-503. PMID: 26077962, PMCID: PMC4553088, PII: S0049-3848(15)30007-4, DOI: 10.1016/j.thromres.2015.05.027, ISSN: 1879-2472.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Reactive ¿-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J Mol Cell Cardiol [print-electronic]. 2015 Feb; 79: 295-302. PMID: 25463275, PMCID: PMC4302000, PII: S0022-2828(14)00373-3, DOI: 10.1016/j.yjmcc.2014.11.013, ISSN: 1095-8584.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ. Protein modification by adenine propenal. Chem Res Toxicol [print-electronic]. 2014 Oct 10/20/2014; 27(10): 1732-42. PMID: 25211669, PMCID: PMC4203390, DOI: 10.1021/tx500218g, ISSN: 1520-5010.

Woodling NS, Wang Q, Priyam PG, Larkin P, Shi J, Johansson JU, Zagol-Ikapitte I, Boutaud O, Andreasson KI. Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling. J Neurosci. 2014 Apr 4/23/2014; 34(17): 5882-94. PMID: 24760848, PMCID: PMC3996215, PII: 34/17/5882, DOI: 10.1523/JNEUROSCI.0410-14.2014, ISSN: 1529-2401.

Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA. Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry [print-electronic]. 2014 Apr 4/22/2014; 53(15): 2436-41. PMID: 24684440, PMCID: PMC4004227, DOI: 10.1021/bi401673b, ISSN: 1520-4995.

Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M. 12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity. Thromb Haemost [print-electronic]. 2013 Sep; 110(3): 569-81. PMID: 23784669, PMCID: PMC3960303, PII: 13-01-0014, DOI: 10.1160/TH13-01-0014, ISSN: 2567-689X.

Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ, Oates JA, Porter NA, Boutaud O. Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues. ACS Med Chem Lett. 2013 Aug 8/8/2013; 4(8): 710-4. PMID: 24482730, PMCID: PMC3904457, DOI: 10.1021/ml4000904, ISSN: 1948-5875.

Yin H, Vergeade A, Shi Q, Zackert WE, Gruenberg KC, Bokiej M, Amin T, Ying W, Masterson TS, Zinkel SS, Oates JA, Boutaud O, Roberts LJ. Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation. Biochem. Biophys. Res. Commun [print-electronic]. 2012 Jun 6/29/2012; 423(2): 224-8. PMID: 22634010, PMCID: PMC3389218, PII: S0006-291X(12)00935-7, DOI: 10.1016/j.bbrc.2012.05.058, ISSN: 1090-2104.

Smith JP, Haddad EV, Taylor MB, Oram D, Blakemore D, Chen Q, Boutaud O, Oates JA. Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Hypertension [print-electronic]. 2012 Mar; 59(3): 719-25. PMID: 22311905, PMCID: PMC3418792, PII: HYPERTENSIONAHA.111.181404, DOI: 10.1161/HYPERTENSIONAHA.111.181404, ISSN: 1524-4563.

Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol [print-electronic]. 2012 Mar; 81(3): 420-30. PMID: 22155783, PMCID: PMC3286293, PII: mol.111.075630, DOI: 10.1124/mol.111.075630, ISSN: 1521-0111.

Boutaud O, Roberts LJ. Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radic. Biol. Med [print-electronic]. 2011 Sep 9/1/2011; 51(5): 1062-7. PMID: 21034813, PMCID: PMC3116013, PII: S0891-5849(10)01343-2, DOI: 10.1016/j.freeradbiomed.2010.10.704, ISSN: 1873-4596.

Chacon A, Zagol-Ikapitte I, Amarnath V, Reyzer ML, Oates JA, Caprioli RM, Boutaud O. On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry. J Mass Spectrom. 2011 Aug; 46(8): 840-6. PMID: 21834023, PMCID: PMC3174490, DOI: 10.1002/jms.1958, ISSN: 1096-9888.

Zagol-Ikapitte I, Amarnath V, Jadhav S, Oates JA, Boutaud O. Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci [print-electronic]. 2011 May 5/1/2011; 879(15-16): 1098-104. PMID: 21489890, PMCID: PMC3091354, PII: S1570-0232(11)00183-8, DOI: 10.1016/j.jchromb.2011.03.026, ISSN: 1873-376X.

Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. Functional characterization of mutations in inherited human cPLA2 deficiency. Biochemistry [print-electronic]. 2011 Mar 3/15/2011; 50(10): 1731-8. PMID: 21247147, PMCID: PMC3051024, DOI: 10.1021/bi101877n, ISSN: 1520-4995.

Holinstat M, Boutaud O, Apopa PL, Vesci J, Bala M, Oates JA, Hamm HE. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2a differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2011 Feb; 31(2): 435-42. PMID: 21127289, PMCID: PMC3035574, PII: ATVBAHA.110.219527, DOI: 10.1161/ATVBAHA.110.219527, ISSN: 1524-4636.

Mosoni L, Balage M, Vazeille E, Combaret L, Morand C, Zagol-Ikapitte I, Boutaud O, Marzani B, Papet I, Dardevet D. Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs. Nutrition [print-electronic]. 2010 Nov; 26(11-12): 1157-62. PMID: 20080031, PII: S0899-9007(09)00408-0, DOI: 10.1016/j.nut.2009.09.016, ISSN: 1873-1244.

Smith JP, Haddad EV, Downey JD, Breyer RM, Boutaud O. PGE2 decreases reactivity of human platelets by activating EP2 and EP4. Thromb. Res [print-electronic]. 2010 Jul; 126(1): e23-9. PMID: 20451959, PMCID: PMC2902561, PII: S0049-3848(10)00228-8, DOI: 10.1016/j.thromres.2010.04.003, ISSN: 1879-2472.

Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ, Davies SS. Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent ¿-Ketoaldehyde Scavenger, by LC/MS/MS. Pharmaceutics. 2010 Mar; 2(1): 18-29. PMID: 21822464, PMCID: PMC3150493, DOI: 10.3390/pharmaceutics2010018, ISSN: 1999-4923.

Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ. Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Feb 2/9/2010; 107(6): 2699-704. PMID: 20133658, PMCID: PMC2823910, PII: 0910174107, DOI: 10.1073/pnas.0910174107, ISSN: 1091-6490.

Zagol-Ikapitte I, Amarnath V, Bala M, Roberts LJ, Oates JA, Boutaud O. Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis. Chem. Res. Toxicol. 2010 Jan; 23(1): 240-50. PMID: 20041722, PMCID: PMC2831641, DOI: 10.1021/tx900407a, ISSN: 1520-5010.

Plunkett J, Doniger S, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Snegovskikh V, Palotie A, Peltonen L, Fellman V, DeFranco EA, Chaudhari BP, Oates J, Boutaud O, McGregor TL, McElroy JJ, Teramo K, Borecki I, Fay JC, Muglia LJ. Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. BMC Med Genomics. 2010; 3: 62. PMID: 21184677, PMCID: PMC3017005, PII: 1755-8794-3-62, DOI: 10.1186/1755-8794-3-62, ISSN: 1755-8794.

Boutaud O, Oates JA. Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes. Methods Mol. Biol. 2010; 644: 67-90. PMID: 20645166, DOI: 10.1007/978-1-59745-364-6_7, ISSN: 1940-6029.

Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA. Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Org. Biomol. Chem [print-electronic]. 2009 Dec 12/21/2009; 7(24): 5103-12. PMID: 20024105, PMCID: PMC2873786, DOI: 10.1039/b912528k, ISSN: 1477-0539.

Carrier EJ, Amarnath V, Oates JA, Boutaud O. Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. Biochemistry. 2009 Nov 11/17/2009; 48(45): 10775-81. PMID: 19824699, PMCID: PMC2824920, DOI: 10.1021/bi9015132, ISSN: 1520-4995.

Potet F, Petersen CI, Boutaud O, Shuai W, Stepanovic SZ, Balser JR, Kupershmidt S. Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator. J. Mol. Cell. Cardiol [print-electronic]. 2009 Feb; 46(2): 257-67. PMID: 19038263, PMCID: PMC2708093, PII: S0022-2828(08)01357-6, DOI: 10.1016/j.yjmcc.2008.10.015, ISSN: 1095-8584.

Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. The enteropathy of prostaglandin deficiency. J. Gastroenterol [print-electronic]. 2009; 44 Suppl 19: 1-7. PMID: 19148786, PMCID: PMC2799331, DOI: 10.1007/s00535-008-2253-y, ISSN: 0944-1174.

Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J. Clin. Invest. 2008 Jun; 118(6): 2121-31. PMID: 18451993, PMCID: PMC2350426, DOI: 10.1172/JCI30473, ISSN: 0021-9738.

Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O, Oates JA. Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem. Pharmacol [print-electronic]. 2008 Apr 4/1/2008; 75(7): 1472-81. PMID: 18242581, PMCID: PMC2693035, PII: S0006-2952(07)00818-0, DOI: 10.1016/j.bcp.2007.12.005, ISSN: 1873-2968.

Davies SS, Amarnath V, Brame CJ, Boutaud O, Roberts LJ. Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc. 2007; 2(9): 2079-91. PMID: 17853863, PII: nprot.2007.298, DOI: 10.1038/nprot.2007.298, ISSN: 1750-2799.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry [print-electronic]. 2006 Dec 12/26/2006; 45(51): 15756-67. PMID: 17176098, PMCID: PMC2597444, DOI: 10.1021/bi061860g, ISSN: 1520-4995.

Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA. PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J. Neurochem [print-electronic]. 2006 Feb; 96(4): 917-23. PMID: 16412101, PMCID: PMC1621054, PII: JNC3586, DOI: 10.1111/j.1471-4159.2005.03586.x, ISSN: 0022-3042.

Aronoff DM, Oates JA, Boutaud O. New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Clin. Pharmacol. Ther. 2006 Jan; 79(1): 9-19. PMID: 16413237, PII: S0009-9236(05)00429-7, DOI: 10.1016/j.clpt.2005.09.009, ISSN: 0009-9236.

Zagol-Ikapitte I, Masterson TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA. Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity. J. Neurochem [print-electronic]. 2005 Aug; 94(4): 1140-5. PMID: 15992375, PII: JNC3264, DOI: 10.1111/j.1471-4159.2005.03264.x, ISSN: 0022-3042.

Boutaud O, Andreasson KI, Zagol-Ikapitte I, Oates JA. Cyclooxygenase-dependent lipid-modification of brain proteins. Brain Pathol. 2005 Apr; 15(2): 139-42. PMID: 15912886, ISSN: 1015-6305.

Zagol-Ikapitte I, Bernoud-Hubac N, Amarnath V, Roberts LJ, Boutaud O, Oates JA. Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry. 2004 May 5/11/2004; 43(18): 5503-10. PMID: 15122916, DOI: 10.1021/bi049842r, ISSN: 0006-2960.

Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem [print-electronic]. 2004 Apr 4/2/2004; 279(14): 13447-51. PMID: 14715668, PII: M313349200, DOI: 10.1074/jbc.M313349200, ISSN: 0021-9258.

Kozak W, Aronoff DM, Boutaud O, Kozak A. 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide. Exp. Biol. Med. (Maywood). 2003 Jul; 228(7): 786-94. PMID: 12876297, ISSN: 1535-3702.

Boutaud O, Li J, Zagol I, Shipp EA, Davies SS, Roberts LJ, Oates JA. Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J. Biol. Chem [print-electronic]. 2003 May 5/9/2003; 278(19): 16926-8. PMID: 12637576, PII: M300940200, DOI: 10.1074/jbc.M300940200, ISSN: 0021-9258.

Sawaoka H, Dixon DA, Oates JA, Boutaud O. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. J. Biol. Chem [print-electronic]. 2003 Apr 4/18/2003; 278(16): 13928-35. PMID: 12578839, PII: M300016200, DOI: 10.1074/jbc.M300016200, ISSN: 0021-9258.

Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J. Pharmacol. Exp. Ther. 2003 Feb; 304(2): 589-95. PMID: 12538810, DOI: 10.1124/jpet.102.042853, ISSN: 0022-3565.

Boutaud O, Dixon DA, Oates JA, Sawaoka H. Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells. Adv. Exp. Med. Biol. 2003; 525: 157-60. PMID: 12751757, ISSN: 0065-2598.

Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. Adv. Exp. Med. Biol. 2003; 525: 125-8. PMID: 12751750, ISSN: 0065-2598.

Cox B, Murphey LJ, Zackert WE, Chinery R, Graves-Deal R, Boutaud O, Oates JA, Coffey RJ, Morrow JD. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. Biochim. Biophys. Acta. 2002 Sep 9/5/2002; 1584(1): 37-45. PMID: 12213491, PII: S1388198102002676, ISSN: 0006-3002.

Boutaud O, Ou JJ, Chaurand P, Caprioli RM, Montine TJ, Oates JA. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J. Neurochem. 2002 Aug; 82(4): 1003-6. PMID: 12358806, PII: 1064, ISSN: 0022-3042.

Smith LH, Boutaud O, Breyer M, Morrow JD, Oates JA, Vaughan DE. Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro. Arterioscler. Thromb. Vasc. Biol. 2002 Jun 6/1/2002; 22(6): 983-8. PMID: 12067908, ISSN: 1524-4636.

Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc. Natl. Acad. Sci. U.S.A. 2002 May 5/14/2002; 99(10): 7130-5. PMID: 12011469, PMCID: PMC124540, PII: 99/10/7130, DOI: 10.1073/pnas.102588199, ISSN: 0027-8424.

Davies SS, Amarnath V, Montine KS, Bernoud-Hubac N, Boutaud O, Montine TJ, Roberts LJ. Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J [print-electronic]. 2002 May; 16(7): 715-7. PMID: 11978738, PII: 01-0696fje, DOI: 10.1096/fj.01-0696fje, ISSN: 1530-6860.

Bernoud-Hubac N, Davies SS, Boutaud O, Montine TJ, Roberts LJ. Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway. J. Biol. Chem [print-electronic]. 2001 Aug 8/17/2001; 276(33): 30964-70. PMID: 11413140, PII: M103768200, DOI: 10.1074/jbc.M103768200, ISSN: 0021-9258.

Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW, Crews BC, Ji C, Marnett LJ, Caprioli RM, Roberts LJ, Oates JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry. 2001 Jun 6/12/2001; 40(23): 6948-55. PMID: 11389610, PII: bi002629k, ISSN: 0006-2960.

Abraham BD, Sono M, Boutaud O, Shriner A, Dawson JH, Brash AR, Gaffney BJ. Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron. Biochemistry. 2001 Feb 2/20/2001; 40(7): 2251-9. PMID: 11329294, PII: bi002121h, ISSN: 0006-2960.

Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ, Roberts LJ, Oates JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv. Exp. Med. Biol. 2001; 500: 133-7. PMID: 11764925, ISSN: 0065-2598.

Benayoud, F., Abouabdellah, A., Richard, C., Bonnet-Delpon, D., B?gu?, J.-P, Levasseur, D., Boutaud, O. and Schuber, F. Trifluoromethyl ketones derived from squalene: inhibition of the cholesterol biosynthesis in HepG2 cells. Tetrahedron Lett. 2000; 41: 6367-70.

Boutaud O, Brash AR. Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. J. Biol. Chem. 1999 Nov 11/19/1999; 274(47): 33764-70. PMID: 10559269, ISSN: 0021-9258.

Boutaud O, Brame CJ, Salomon RG, Roberts LJ, Oates JA. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry. 1999 Jul 7/20/1999; 38(29): 9389-96. PMID: 10413514, PII: bi990470+, DOI: 10.1021/bi990470+, ISSN: 0006-2960.

Koljak R, Boutaud O, Shieh BH, Samel N, Brash AR. Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. Science. 1997 Sep 9/26/1997; 277(5334): 1994-6. PMID: 9302294, ISSN: 0036-8075.

Viola F, Brusa P, Balliano G, Ceruti M, Boutaud O, Schuber F, Cattel L. Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. Biochem. Pharmacol. 1995 Sep 9/7/1995; 50(6): 787-96. PMID: 7575639, PII: 0006-2952(95)00201-A, ISSN: 0006-2952.

Boutaud O, Ceruti M, Cattel L, Schuber F. Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. Biochem. Biophys. Res. Commun. 1995 Mar 3/8/1995; 208(1): 42-7. PMID: 7887959, PII: S0006-291X(85)71302-2, DOI: 10.1006/bbrc.1995.1302, ISSN: 0006-291X.

Boutaud O, Dolis D, Schuber F. Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase. Biochem. Biophys. Res. Commun. 1992 Oct 10/30/1992; 188(2): 898-904. PMID: 1445330, PII: 0006-291X(92)91140-L, ISSN: 0006-291X.