John Thomas Clark, Ph.D.

Faculty Appointments
Professor of Endorinology and Reproductive Biology at Meharry Medical College
Ph.D., Physiology, Stanford University, Stanford, CaliforniaM.A., Physiology/Behavioral Biology, San Francisco State University, San Francisco, CaliforniaB.A., Biology, Long Island University, Southampton, New York
Office Address
Meharry Medical College
2218 H.D. West Basic Sciences Center
1005 Dr. D.B. Todd Jr. Blvd.
Nashville, TN 37208-3599
Research Keywords
Hormones and sexual and cardiovascular function in relationship to aging
CLARK, J.T., Keaton, A.K., Sahu, A., Kalra, S.P., Mahajan, S.C., and Gudger, J.N. Neuropeptide Y (NPY) levels in alcoholic and foodrestricted male rats: Implications for site selective function. 1998.

Keaton AK, Clark JT. Effects of angiotensin II on sexual function, blood pressure, and fluid intake are differentially affected by AT-1 receptor blockade. Physiol Behav. 1998; 64(3): 339-46.

Clark JT, Kalra PS, Kalra SP. Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. 1985. Obes Res. 1997; 5: 275-83.

Smith, E.R., Kacker, S., Raskin, A., Yun, P.T., Davidson, J.M., Hoffman, B.B., and Clark, J.T. Central propranolol and pindolol, but nor atenolol nor metoprolol, inhibit sexual behavior in male rats. Phys. And Behavior. 1996; 59: 241-6.

CLARK, JT. Sexual function in altered physiological states - comparison of effects of hypertension, diabetes, hyperprolactinemia and others to "normal" aging in male rats. 1995.

Clark JT, Micevych PE, Panossian V, Keaton AK. Testosterone-induced copulatory behavior is affected by the postcastration interval. Neurosci Biobehav Rev. 1995; 19(3): 369-76.

Smith, E.R., Cetrulo, E.J., Donahue, J.P., Sparrow, H., Davidson, J.M., Hoffman, B.B. and CLARK, J.T. The inhibitory effects of propranolol on genital reflexes in male rats. Pharm. Biochem. And Behavior. 1995; 52: 541-6.

Smith, E.R., Stoker, D., Kueny, T., Davidson, J.M., Hoffmann, B.B., and Clark, J.T. The inhibition of sexual behavior in male rats by propranolol is stereo-selective. Pharm Biochem and Behavior. 1995; 51: 439-42.

Floyd, E.A., Keaton, A.K., Clark, J.T., and Rucker, H.K. Chronic alcohol ingestion alters parameters of mid-latency evoked potentials in male rats. Alcohol. 1995; 12: 15-22.

CLARK, JT. Aging-induced decrements in neuropeptide Y: the retention of ejaculatory behavior is associated with site-selective differences. 1994.

Smith ER, Stefanick ML, Clark JT, Davidson JM. Hormones and sexual behavior in relationship to aging in male rats. 1992.

Clark, J.T. , a putative neuropeptide Y receptor antagonist, attenuates the termination of receptivity. Physiology and Behavior. 1992; 52: 965-9.

Clark JT. Suppression of copulatory behavior in male rats following central administration of clonidine. Neuropharmacology. 1991; 30(4): 373-82.

Clark JT, Sahu A, Mrotek JJ, Kalra SP. Sexual function and neuropeptide Y levels in selected brain regions in male spontaneously hypertensive rats. Am J Physiol. 1991; 261(5 Pt 2).

Clark JT, Smith ER. Clonidine suppresses copulatory behavior and erectile reflexes in male rats: lack of effect of naloxone pretreatment. Neuroendocrinology. 1990; 51(3): 357-64.

Clark, J.T. A possible role for angiotensin II in the regulation of male sexual behavior in rats. PHYSIOLOGY AND Behavior. 1989; 45: 221 224.

Clark JT, Gabriel SM, Simpkins JW, Kalra SP, Kalra PS. Chronic morphine and testosterone treatment. Effects on sexual behavior and dopamine metabolism in male rats. Neuroendocrinology. 1988; 48: 97-104.

Gabriel SM, Clark JT, Kalra PS, Kalra SP, Simpkins JW. Chronic morphine and testosterone treatment: effects on norepinephrine and serotonin metabolism and gonadotropin secretion in male rats. Brain Res. 1988; 447: 200-3.

Kalra SP, Clark JT, Sahu A, Dube MG, Kalra PS. Control of feeding and sexual behaviors by neuropeptide Y: physiological implications. Synapse. 1988; 2: 254-7.

Clark JT, Gist RS, Kalra SP, Kalra PS. Alpha 2-adrenoceptor blockade attenuates feeding behavior induced by neuropeptide Y and epinephrine. Physiol Behav. 1988; 43: 417-22.

Clark JT, Kalra SP, Kalra PS. Effects of a selective alpha 1-adrenoceptor agonist, methoxamine, on sexual behavior and penile reflexes. Physiol Behav. 1987; 40: 747-53.

Clark JT, Sahu A, Kalra PS, Balasubramaniam A, Kalra SP. Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY ([Met17]NPY), NPY analog ([norLeu4]NPY) and peptide YY. Regul Pept. 1987; 17: 31-9.

Clark JT, Simpkins JW, Kalra SP. Long-term weekly gonadal steroid treatment: effects on plasma prolactin, sexual behavior and hypothalamic-preoptic area catecholamines. Neuroendocrinology. 1986; 44: 488-93.

Clark JT, Kalra PS, Kalra SP. Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. Endocrinology. 1985; 117: 2435-42.

Clark, J.T., Smith, E.R., and Davidson, J.M. Evidence for the modulation of sexual behavior by alpha-adrenoceptors in male rats. Neuroendocrinol. 1985; 41: 36 43.

CLARK, J.T., Kalra, P.S., Crowley, W.R. and Kalra. S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. 1984.

CLARK, J.T., Smith, E.R., and Davidson, J.M. Enhancement of sexual motivation in male rats by yohimbine. 1984.