Faculty Appointments
Professor of Obstetrics & Gynecology
Education
Ph.D., Pathology, Vanderbilt University, Nashville, TennesseeB.S., Chemistry and Biology, Delta State University, Cleveland, Mississippi
Office Address
B-1100 MCN
TN 2519
TN 2519
Research Keywords
Normal and abnormal cell-cell communication within the female reproductive tract; paternal contribution to preterm birth, nutritional intervention and pregnancy outcomes
Publications
Stocks MM, Crispens MA, Ding T, Mokshagundam S, Bruner-Tran KL, Osteen KG. Therapeutically Targeting the Inflammasome Product in a Chimeric Model of Endometriosis-Related Surgical Adhesions. Reprod Sci [print-electronic]. 2017 Aug; 24(8): 1121-8. PMID: 28322132, DOI: 10.1177/1933719117698584, ISSN: 1933-7205.
Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium. Ann Biomed Eng [print-electronic]. 2017 Jul; 45(7): 1758-69. PMID: 28108942, PMCID: PMC5489603, PII: 10.1007/s10439-017-1797-5, DOI: 10.1007/s10439-017-1797-5, ISSN: 1573-9686.
Bruner-Tran KL, Gnecco J, Ding T, Glore DR, Pensabene V, Osteen KG. Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models. Reprod. Toxicol [print-electronic]. 2016 Jul 7/14/2016; PMID: 27423904, PII: S0890-6238(16)30264-7, DOI: 10.1016/j.reprotox.2016.07.007, ISSN: 1873-1708.
Palmer SS, Altan M, Denis D, Tos EG, Gotteland JP, Osteen KG, Bruner-Tran KL, Nataraja SG. Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models. Reprod Sci [print-electronic]. 2016 Jan; 23(1): 11-23. PMID: 26335175, PII: 1933719115600553, DOI: 10.1177/1933719115600553, ISSN: 1933-7205.
Arosh JA, Lee J, Balasubbramanian D, Stanley JA, Long CR, Meagher MW, Osteen KG, Bruner-Tran KL, Burghardt RC, Starzinski-Powitz A, Banu SK. Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Aug 8/4/2015; 112(31): 9716-21. PMID: 26199416, PMCID: PMC4534219, PII: 1507931112, DOI: 10.1073/pnas.1507931112, ISSN: 1091-6490.
Bruner-Tran KL, Ding T, Yeoman KB, Archibong A, Arosh JA, Osteen KG. Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners. PLoS ONE. 2014; 9(8): e105084. PMID: 25127480, PMCID: PMC4134254, PII: PONE-D-14-17233, DOI: 10.1371/journal.pone.0105084, ISSN: 1932-6203.
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Ginecol. 2013 Apr; 65(2): 199-213. PMID: 23598784, PMCID: PMC3718308, PII: R09133452, ISSN: 0026-4784.
Villanueva JA, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J. Clin. Endocrinol. Metab [print-electronic]. 2013 Mar; 98(3): E455-62. PMID: 23386644, PMCID: PMC3590465, PII: jc.2012-3387, DOI: 10.1210/jc.2012-3387, ISSN: 1945-7197.
Sokalska A, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J. Clin. Endocrinol. Metab [print-electronic]. 2013 Mar; 98(3): E463-71. PMID: 23337719, PMCID: PMC3590479, PII: jc.2012-3402, DOI: 10.1210/jc.2012-3402, ISSN: 1945-7197.
Herington JL, Glore DR, Lucas JA, Osteen KG, Bruner-Tran KL. Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model. Fertil. Steril [print-electronic]. 2013 Feb; 99(2): 543-50. PMID: 23103017, PMCID: PMC3582352, PII: S0015-0282(12)02307-2, DOI: 10.1016/j.fertnstert.2012.10.007, ISSN: 1556-5653.
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertil. Steril [print-electronic]. 2012 Oct; 98(4): 948-56.e1. PMID: 22789143, PMCID: PMC3462249, PII: S0015-0282(12)00644-9, DOI: 10.1016/j.fertnstert.2012.06.009, ISSN: 1556-5653.
Bruner-Tran KL, Resuehr D, Ding T, Lucas JA, Osteen KG. The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans. Curr Obstet Gynecol Rep. 2012 Sep 9/1/2012; 1(3): 116-23. PMID: 24932427, PMCID: PMC4056573, DOI: 10.1007/s13669-012-0014-7, ISSN: 2161-3303.
Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Simvastatin decreases invasiveness of human endometrial stromal cells. Biol. Reprod [electronic-print]. 2012 Jul; 87(1): 2, 1-6. PMID: 22492974, PMCID: PMC3406552, PII: biolreprod.111.098806, DOI: 10.1095/biolreprod.111.098806, ISSN: 1529-7268.
Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel therapies targeting endometriosis. Reprod Sci [print-electronic]. 2011 Sep; 18(9): 814-23. PMID: 21693775, PMCID: PMC4046304, PII: 1933719111410713, DOI: 10.1177/1933719111410713, ISSN: 1933-7205.
Herington JL, Bruner-Tran KL, Lucas JA, Osteen KG. Immune interactions in endometriosis. Expert Rev Clin Immunol. 2011 Sep; 7(5): 611-26. PMID: 21895474, PMCID: PMC3204940, DOI: 10.1586/eci.11.53, ISSN: 1744-8409.
McConaha ME, Ding T, Lucas JA, Arosh JA, Osteen KG, Bruner-Tran KL. Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners. Reproduction [print-electronic]. 2011 Aug; 142(2): 235-41. PMID: 21653731, PMCID: PMC3730265, PII: REP-11-0070, DOI: 10.1530/REP-11-0070, ISSN: 1741-7899.
Ding T, McConaha M, Boyd KL, Osteen KG, Bruner-Tran KL. Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice. Reprod. Toxicol [print-electronic]. 2011 Apr; 31(3): 351-8. PMID: 21093581, PMCID: PMC3075349, PII: S0890-6238(10)00327-8, DOI: 10.1016/j.reprotox.2010.11.003, ISSN: 1873-1708.
Bruner-Tran KL, Osteen KG. Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod. Toxicol [print-electronic]. 2011 Apr; 31(3): 344-50. PMID: 20955784, PMCID: PMC3044210, PII: S0890-6238(10)00314-X, DOI: 10.1016/j.reprotox.2010.10.003, ISSN: 1873-1708.
Herington JL, Crispens MA, Carvalho-Macedo AC, Camargos AF, Lebovic DI, Bruner-Tran KL, Osteen KG. Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Fertil. Steril [print-electronic]. 2011 Mar 3/15/2011; 95(4): 1295-301.e1. PMID: 20934690, PMCID: PMC3038191, PII: S0015-0282(10)02547-1, DOI: 10.1016/j.fertnstert.2010.09.017, ISSN: 1556-5653.
Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ. Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Biol. Reprod [print-electronic]. 2011 Jan; 84(1): 106-12. PMID: 20844278, PMCID: PMC3012565, PII: biolreprod.110.086744, DOI: 10.1095/biolreprod.110.086744, ISSN: 1529-7268.
Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil. Steril [print-electronic]. 2010 May 5/15/2010; 93(8): 2519-24. PMID: 19608172, PMCID: PMC2873129, PII: S0015-0282(09)01231-X, DOI: 10.1016/j.fertnstert.2009.05.076, ISSN: 1556-5653.
Bruner-Tran KL, Osteen KG. Dioxin-like PCBs and endometriosis. Syst Biol Reprod Med. 2010 Apr; 56(2): 132-46. PMID: 20377312, PMCID: PMC2867352, DOI: 10.3109/19396360903381023, ISSN: 1939-6376.
Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ. The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. Am. J. Pathol [print-electronic]. 2010 Feb; 176(2): 1050-6. PMID: 20042667, PMCID: PMC2808107, PII: S0002-9440(10)60414-2, DOI: 10.2353/ajpath.2010.090757, ISSN: 1525-2191.
Bruner-Tran KL, Ding T, Osteen KG. Dioxin and endometrial progesterone resistance. Semin. Reprod. Med [print-electronic]. 2010 Jan; 28(1): 59-68. PMID: 20104429, PMCID: PMC2875884, DOI: 10.1055/s-0029-1242995, ISSN: 1526-4564.
Bruner-Tran KL, Osteen KG, Duleba AJ. Simvastatin protects against the development of endometriosis in a nude mouse model. J. Clin. Endocrinol. Metab [print-electronic]. 2009 Jul; 94(7): 2489-94. PMID: 19366846, PMCID: PMC2708947, PII: jc.2008-2802, DOI: 10.1210/jc.2008-2802, ISSN: 1945-7197.
Bruner-Tran KL, Yeaman GR, Crispens MA, Igarashi TM, Osteen KG. Dioxin may promote inflammation-related development of endometriosis. Fertil. Steril [print-electronic]. 2008 May; 89(5 Suppl): 1287-98. PMID: 18394613, PMCID: PMC2430157, PII: S0015-0282(08)00367-1, DOI: 10.1016/j.fertnstert.2008.02.102, ISSN: 1556-5653.
Nayyar T, Bruner-Tran KL, Piestrzeniewicz-Ulanska D, Osteen KG. Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Reprod. Toxicol [print-electronic]. 2007 Apr; 23(3): 326-36. PMID: 17056225, PMCID: PMC1885235, PII: S0890-6238(06)00238-3, DOI: 10.1016/j.reprotox.2006.09.007, ISSN: 0890-6238.
Bruner-Tran KL, Zhang Z, Eisenberg E, Winneker RC, Osteen KG. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J. Clin. Endocrinol. Metab [print-electronic]. 2006 Apr; 91(4): 1554-60. PMID: 16418212, PII: jc.2005-2024, DOI: 10.1210/jc.2005-2024, ISSN: 0021-972X.
Igarashi TM, Bruner-Tran KL, Yeaman GR, Lessey BA, Edwards DP, Eisenberg E, Osteen KG. Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil. Steril. 2005 Jul; 84(1): 67-74. PMID: 16009159, PII: S0015-0282(05)00593-5, DOI: 10.1016/j.fertnstert.2005.01.113, ISSN: 1556-5653.
Osteen KG, Bruner-Tran KL, Eisenberg E. Endometrial biology and the etiology of endometriosis. Fertil. Steril. 2005 Jul; 84(1): 33-4; discussion 38. PMID: 16009151, PII: S0015-0282(05)00663-1, DOI: 10.1016/j.fertnstert.2005.01.124, ISSN: 1556-5653.
Kurita T, Medina R, Schabel AB, Young P, Gama P, Parekh TV, Brody J, Cunha GR, Osteen KG, Bruner-Tran KL, Gold LI. The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen. Differentiation. 2005 Jul; 73(6): 313-22. PMID: 16138832, PII: S0301-4681(09)60342-X, DOI: 10.1111/j.1432-0436.2005.00033.x, ISSN: 0301-4681.
Harris HA, Bruner-Tran KL, Zhang X, Osteen KG, Lyttle CR. A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Hum. Reprod [print-electronic]. 2005 Apr; 20(4): 936-41. PMID: 15618247, PII: deh711, DOI: 10.1093/humrep/deh711, ISSN: 0268-1161.
Osteen KG, Bruner-Tran KL, Eisenberg E. Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Fertil. Steril. 2005 Mar; 83(3): 529-37. PMID: 15749474, PII: S0015-0282(04)03187-5, DOI: 10.1016/j.fertnstert.2004.11.026, ISSN: 0015-0282.
Osteen KG, Igarashi TM, Yeaman GR, Bruner-Tran KL. Steroid and cytokine regulation of matrix metalloproteinases and the pathophysiology of endometriosis. Gynecol. Obstet. Invest. 2004; 57(1): 53-4. PMID: 14974460, ISSN: 0378-7346.
Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK. Antiangiogenic agents are effective inhibitors of endometriosis. J. Clin. Endocrinol. Metab. 2003 Jun; 88(6): 2889-99. PMID: 12788903, DOI: 10.1210/jc.2002-021912, ISSN: 0021-972X.
Osteen KG, Yeaman GR, Bruner-Tran KL. Matrix metalloproteinases and endometriosis. Semin. Reprod. Med. 2003 May; 21(2): 155-64. PMID: 12917785, DOI: 10.1055/s-2003-41322, ISSN: 1526-8004.
Osteen KG, Igarashi TM, Bruner-Tran KL. Progesterone action in the human endometrium: induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression. Front. Biosci. 2003 Jan 1/1/2003; 8: d78-86. PMID: 12456342, ISSN: 1093-9946.
Bruner-Tran KL, Eisenberg E, Yeaman GR, Anderson TA, McBean J, Osteen KG. Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J. Clin. Endocrinol. Metab. 2002 Oct; 87(10): 4782-91. PMID: 12364474, DOI: 10.1210/jc.2002-020418, ISSN: 0021-972X.
Osteen KG, Bruner-Tran KL, Keller NR, Eisenberg E. Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosis. Ann. N. Y. Acad. Sci. 2002 Mar; 955: 37-47; discussion 86. PMID: 11949963, ISSN: 0077-8923.
Bruner-Tran KL, Webster-Clair D, Osteen KG. Experimental endometriosis: the nude mouse as a xenographic host. Ann. N. Y. Acad. Sci. 2002 Mar; 955: 328-39; discussion 340. PMID: 11949959, ISSN: 0077-8923.
Osteen KG, Bruner-Tran KL, Ong D, Eisenberg E. Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis. Ann. N. Y. Acad. Sci. 2002 Mar; 955: 139-46; discussion 157. PMID: 11949943, ISSN: 0077-8923.
Bruner KL, Eisenberg E, Gorstein F, Osteen KG. Progesterone and transforming growth factor-beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids. 1999 Sep; 64(9): 648-53. PMID: 10503723, PII: S0039-128X(99)00048-3, ISSN: 0039-128X.
Bruner-Tran KL, Rier SE, Eisenberg E, Osteen KG. The potential role of environmental toxins in the pathophysiology of endometriosis. Gynecol. Obstet. Invest. 1999; 48 Suppl 1: 45-56. PMID: 10559664, PII: 52868, DOI: 52868, ISSN: 0378-7346.
Bruner KL, Matrisian LM, Rodgers WH, Gorstein F, Osteen KG. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J. Clin. Invest. 1997 Jun 6/15/1997; 99(12): 2851-7. PMID: 9185507, PMCID: PMC508135, DOI: 10.1172/JCI119478, ISSN: 0021-9738.
Osteen KG, Bruner KL, Sharpe-Timms KL. Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis. Semin. Reprod. Endocrinol. 1996 Aug; 14(3): 247-55. PMID: 8885055, DOI: 10.1055/s-2007-1016334, ISSN: 0734-8630.
Bruner KL, Rodgers WH, Gold LI, Korc M, Hargrove JT, Matrisian LM, Osteen KG. Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Proc. Natl. Acad. Sci. U.S.A. 1995 Aug 8/1/1995; 92(16): 7362-6. PMID: 7638197, PMCID: PMC41339, ISSN: 0027-8424.
Cmarik JL, Humphreys WG, Bruner KL, Lloyd RS, Tibbetts C, Guengerich FP. Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide. J. Biol. Chem. 1992 Apr 4/5/1992; 267(10): 6672-9. PMID: 1551876, ISSN: 0021-9258.
Bowling JM, Bruner KL, Cmarik JL, Tibbetts C. Neighboring nucleotide interactions during DNA sequencing gel electrophoresis. Nucleic Acids Res. 1991 Jun 6/11/1991; 19(11): 3089-97. PMID: 2057365, PMCID: PMC328275, ISSN: 0305-1048.
Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium. Ann Biomed Eng [print-electronic]. 2017 Jul; 45(7): 1758-69. PMID: 28108942, PMCID: PMC5489603, PII: 10.1007/s10439-017-1797-5, DOI: 10.1007/s10439-017-1797-5, ISSN: 1573-9686.
Bruner-Tran KL, Gnecco J, Ding T, Glore DR, Pensabene V, Osteen KG. Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models. Reprod. Toxicol [print-electronic]. 2016 Jul 7/14/2016; PMID: 27423904, PII: S0890-6238(16)30264-7, DOI: 10.1016/j.reprotox.2016.07.007, ISSN: 1873-1708.
Palmer SS, Altan M, Denis D, Tos EG, Gotteland JP, Osteen KG, Bruner-Tran KL, Nataraja SG. Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models. Reprod Sci [print-electronic]. 2016 Jan; 23(1): 11-23. PMID: 26335175, PII: 1933719115600553, DOI: 10.1177/1933719115600553, ISSN: 1933-7205.
Arosh JA, Lee J, Balasubbramanian D, Stanley JA, Long CR, Meagher MW, Osteen KG, Bruner-Tran KL, Burghardt RC, Starzinski-Powitz A, Banu SK. Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Aug 8/4/2015; 112(31): 9716-21. PMID: 26199416, PMCID: PMC4534219, PII: 1507931112, DOI: 10.1073/pnas.1507931112, ISSN: 1091-6490.
Bruner-Tran KL, Ding T, Yeoman KB, Archibong A, Arosh JA, Osteen KG. Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners. PLoS ONE. 2014; 9(8): e105084. PMID: 25127480, PMCID: PMC4134254, PII: PONE-D-14-17233, DOI: 10.1371/journal.pone.0105084, ISSN: 1932-6203.
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Ginecol. 2013 Apr; 65(2): 199-213. PMID: 23598784, PMCID: PMC3718308, PII: R09133452, ISSN: 0026-4784.
Villanueva JA, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J. Clin. Endocrinol. Metab [print-electronic]. 2013 Mar; 98(3): E455-62. PMID: 23386644, PMCID: PMC3590465, PII: jc.2012-3387, DOI: 10.1210/jc.2012-3387, ISSN: 1945-7197.
Sokalska A, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J. Clin. Endocrinol. Metab [print-electronic]. 2013 Mar; 98(3): E463-71. PMID: 23337719, PMCID: PMC3590479, PII: jc.2012-3402, DOI: 10.1210/jc.2012-3402, ISSN: 1945-7197.
Herington JL, Glore DR, Lucas JA, Osteen KG, Bruner-Tran KL. Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model. Fertil. Steril [print-electronic]. 2013 Feb; 99(2): 543-50. PMID: 23103017, PMCID: PMC3582352, PII: S0015-0282(12)02307-2, DOI: 10.1016/j.fertnstert.2012.10.007, ISSN: 1556-5653.
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertil. Steril [print-electronic]. 2012 Oct; 98(4): 948-56.e1. PMID: 22789143, PMCID: PMC3462249, PII: S0015-0282(12)00644-9, DOI: 10.1016/j.fertnstert.2012.06.009, ISSN: 1556-5653.
Bruner-Tran KL, Resuehr D, Ding T, Lucas JA, Osteen KG. The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans. Curr Obstet Gynecol Rep. 2012 Sep 9/1/2012; 1(3): 116-23. PMID: 24932427, PMCID: PMC4056573, DOI: 10.1007/s13669-012-0014-7, ISSN: 2161-3303.
Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Simvastatin decreases invasiveness of human endometrial stromal cells. Biol. Reprod [electronic-print]. 2012 Jul; 87(1): 2, 1-6. PMID: 22492974, PMCID: PMC3406552, PII: biolreprod.111.098806, DOI: 10.1095/biolreprod.111.098806, ISSN: 1529-7268.
Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel therapies targeting endometriosis. Reprod Sci [print-electronic]. 2011 Sep; 18(9): 814-23. PMID: 21693775, PMCID: PMC4046304, PII: 1933719111410713, DOI: 10.1177/1933719111410713, ISSN: 1933-7205.
Herington JL, Bruner-Tran KL, Lucas JA, Osteen KG. Immune interactions in endometriosis. Expert Rev Clin Immunol. 2011 Sep; 7(5): 611-26. PMID: 21895474, PMCID: PMC3204940, DOI: 10.1586/eci.11.53, ISSN: 1744-8409.
McConaha ME, Ding T, Lucas JA, Arosh JA, Osteen KG, Bruner-Tran KL. Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners. Reproduction [print-electronic]. 2011 Aug; 142(2): 235-41. PMID: 21653731, PMCID: PMC3730265, PII: REP-11-0070, DOI: 10.1530/REP-11-0070, ISSN: 1741-7899.
Ding T, McConaha M, Boyd KL, Osteen KG, Bruner-Tran KL. Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice. Reprod. Toxicol [print-electronic]. 2011 Apr; 31(3): 351-8. PMID: 21093581, PMCID: PMC3075349, PII: S0890-6238(10)00327-8, DOI: 10.1016/j.reprotox.2010.11.003, ISSN: 1873-1708.
Bruner-Tran KL, Osteen KG. Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod. Toxicol [print-electronic]. 2011 Apr; 31(3): 344-50. PMID: 20955784, PMCID: PMC3044210, PII: S0890-6238(10)00314-X, DOI: 10.1016/j.reprotox.2010.10.003, ISSN: 1873-1708.
Herington JL, Crispens MA, Carvalho-Macedo AC, Camargos AF, Lebovic DI, Bruner-Tran KL, Osteen KG. Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Fertil. Steril [print-electronic]. 2011 Mar 3/15/2011; 95(4): 1295-301.e1. PMID: 20934690, PMCID: PMC3038191, PII: S0015-0282(10)02547-1, DOI: 10.1016/j.fertnstert.2010.09.017, ISSN: 1556-5653.
Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ. Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Biol. Reprod [print-electronic]. 2011 Jan; 84(1): 106-12. PMID: 20844278, PMCID: PMC3012565, PII: biolreprod.110.086744, DOI: 10.1095/biolreprod.110.086744, ISSN: 1529-7268.
Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil. Steril [print-electronic]. 2010 May 5/15/2010; 93(8): 2519-24. PMID: 19608172, PMCID: PMC2873129, PII: S0015-0282(09)01231-X, DOI: 10.1016/j.fertnstert.2009.05.076, ISSN: 1556-5653.
Bruner-Tran KL, Osteen KG. Dioxin-like PCBs and endometriosis. Syst Biol Reprod Med. 2010 Apr; 56(2): 132-46. PMID: 20377312, PMCID: PMC2867352, DOI: 10.3109/19396360903381023, ISSN: 1939-6376.
Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ. The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. Am. J. Pathol [print-electronic]. 2010 Feb; 176(2): 1050-6. PMID: 20042667, PMCID: PMC2808107, PII: S0002-9440(10)60414-2, DOI: 10.2353/ajpath.2010.090757, ISSN: 1525-2191.
Bruner-Tran KL, Ding T, Osteen KG. Dioxin and endometrial progesterone resistance. Semin. Reprod. Med [print-electronic]. 2010 Jan; 28(1): 59-68. PMID: 20104429, PMCID: PMC2875884, DOI: 10.1055/s-0029-1242995, ISSN: 1526-4564.
Bruner-Tran KL, Osteen KG, Duleba AJ. Simvastatin protects against the development of endometriosis in a nude mouse model. J. Clin. Endocrinol. Metab [print-electronic]. 2009 Jul; 94(7): 2489-94. PMID: 19366846, PMCID: PMC2708947, PII: jc.2008-2802, DOI: 10.1210/jc.2008-2802, ISSN: 1945-7197.
Bruner-Tran KL, Yeaman GR, Crispens MA, Igarashi TM, Osteen KG. Dioxin may promote inflammation-related development of endometriosis. Fertil. Steril [print-electronic]. 2008 May; 89(5 Suppl): 1287-98. PMID: 18394613, PMCID: PMC2430157, PII: S0015-0282(08)00367-1, DOI: 10.1016/j.fertnstert.2008.02.102, ISSN: 1556-5653.
Nayyar T, Bruner-Tran KL, Piestrzeniewicz-Ulanska D, Osteen KG. Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Reprod. Toxicol [print-electronic]. 2007 Apr; 23(3): 326-36. PMID: 17056225, PMCID: PMC1885235, PII: S0890-6238(06)00238-3, DOI: 10.1016/j.reprotox.2006.09.007, ISSN: 0890-6238.
Bruner-Tran KL, Zhang Z, Eisenberg E, Winneker RC, Osteen KG. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J. Clin. Endocrinol. Metab [print-electronic]. 2006 Apr; 91(4): 1554-60. PMID: 16418212, PII: jc.2005-2024, DOI: 10.1210/jc.2005-2024, ISSN: 0021-972X.
Igarashi TM, Bruner-Tran KL, Yeaman GR, Lessey BA, Edwards DP, Eisenberg E, Osteen KG. Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil. Steril. 2005 Jul; 84(1): 67-74. PMID: 16009159, PII: S0015-0282(05)00593-5, DOI: 10.1016/j.fertnstert.2005.01.113, ISSN: 1556-5653.
Osteen KG, Bruner-Tran KL, Eisenberg E. Endometrial biology and the etiology of endometriosis. Fertil. Steril. 2005 Jul; 84(1): 33-4; discussion 38. PMID: 16009151, PII: S0015-0282(05)00663-1, DOI: 10.1016/j.fertnstert.2005.01.124, ISSN: 1556-5653.
Kurita T, Medina R, Schabel AB, Young P, Gama P, Parekh TV, Brody J, Cunha GR, Osteen KG, Bruner-Tran KL, Gold LI. The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen. Differentiation. 2005 Jul; 73(6): 313-22. PMID: 16138832, PII: S0301-4681(09)60342-X, DOI: 10.1111/j.1432-0436.2005.00033.x, ISSN: 0301-4681.
Harris HA, Bruner-Tran KL, Zhang X, Osteen KG, Lyttle CR. A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Hum. Reprod [print-electronic]. 2005 Apr; 20(4): 936-41. PMID: 15618247, PII: deh711, DOI: 10.1093/humrep/deh711, ISSN: 0268-1161.
Osteen KG, Bruner-Tran KL, Eisenberg E. Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Fertil. Steril. 2005 Mar; 83(3): 529-37. PMID: 15749474, PII: S0015-0282(04)03187-5, DOI: 10.1016/j.fertnstert.2004.11.026, ISSN: 0015-0282.
Osteen KG, Igarashi TM, Yeaman GR, Bruner-Tran KL. Steroid and cytokine regulation of matrix metalloproteinases and the pathophysiology of endometriosis. Gynecol. Obstet. Invest. 2004; 57(1): 53-4. PMID: 14974460, ISSN: 0378-7346.
Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK. Antiangiogenic agents are effective inhibitors of endometriosis. J. Clin. Endocrinol. Metab. 2003 Jun; 88(6): 2889-99. PMID: 12788903, DOI: 10.1210/jc.2002-021912, ISSN: 0021-972X.
Osteen KG, Yeaman GR, Bruner-Tran KL. Matrix metalloproteinases and endometriosis. Semin. Reprod. Med. 2003 May; 21(2): 155-64. PMID: 12917785, DOI: 10.1055/s-2003-41322, ISSN: 1526-8004.
Osteen KG, Igarashi TM, Bruner-Tran KL. Progesterone action in the human endometrium: induction of a unique tissue environment which limits matrix metalloproteinase (MMP) expression. Front. Biosci. 2003 Jan 1/1/2003; 8: d78-86. PMID: 12456342, ISSN: 1093-9946.
Bruner-Tran KL, Eisenberg E, Yeaman GR, Anderson TA, McBean J, Osteen KG. Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J. Clin. Endocrinol. Metab. 2002 Oct; 87(10): 4782-91. PMID: 12364474, DOI: 10.1210/jc.2002-020418, ISSN: 0021-972X.
Osteen KG, Bruner-Tran KL, Keller NR, Eisenberg E. Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosis. Ann. N. Y. Acad. Sci. 2002 Mar; 955: 37-47; discussion 86. PMID: 11949963, ISSN: 0077-8923.
Bruner-Tran KL, Webster-Clair D, Osteen KG. Experimental endometriosis: the nude mouse as a xenographic host. Ann. N. Y. Acad. Sci. 2002 Mar; 955: 328-39; discussion 340. PMID: 11949959, ISSN: 0077-8923.
Osteen KG, Bruner-Tran KL, Ong D, Eisenberg E. Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis. Ann. N. Y. Acad. Sci. 2002 Mar; 955: 139-46; discussion 157. PMID: 11949943, ISSN: 0077-8923.
Bruner KL, Eisenberg E, Gorstein F, Osteen KG. Progesterone and transforming growth factor-beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids. 1999 Sep; 64(9): 648-53. PMID: 10503723, PII: S0039-128X(99)00048-3, ISSN: 0039-128X.
Bruner-Tran KL, Rier SE, Eisenberg E, Osteen KG. The potential role of environmental toxins in the pathophysiology of endometriosis. Gynecol. Obstet. Invest. 1999; 48 Suppl 1: 45-56. PMID: 10559664, PII: 52868, DOI: 52868, ISSN: 0378-7346.
Bruner KL, Matrisian LM, Rodgers WH, Gorstein F, Osteen KG. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J. Clin. Invest. 1997 Jun 6/15/1997; 99(12): 2851-7. PMID: 9185507, PMCID: PMC508135, DOI: 10.1172/JCI119478, ISSN: 0021-9738.
Osteen KG, Bruner KL, Sharpe-Timms KL. Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis. Semin. Reprod. Endocrinol. 1996 Aug; 14(3): 247-55. PMID: 8885055, DOI: 10.1055/s-2007-1016334, ISSN: 0734-8630.
Bruner KL, Rodgers WH, Gold LI, Korc M, Hargrove JT, Matrisian LM, Osteen KG. Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Proc. Natl. Acad. Sci. U.S.A. 1995 Aug 8/1/1995; 92(16): 7362-6. PMID: 7638197, PMCID: PMC41339, ISSN: 0027-8424.
Cmarik JL, Humphreys WG, Bruner KL, Lloyd RS, Tibbetts C, Guengerich FP. Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide. J. Biol. Chem. 1992 Apr 4/5/1992; 267(10): 6672-9. PMID: 1551876, ISSN: 0021-9258.
Bowling JM, Bruner KL, Cmarik JL, Tibbetts C. Neighboring nucleotide interactions during DNA sequencing gel electrophoresis. Nucleic Acids Res. 1991 Jun 6/11/1991; 19(11): 3089-97. PMID: 2057365, PMCID: PMC328275, ISSN: 0305-1048.