Joseph A. Smith, Jr., M.D.

Faculty Appointments
Professor of Urology William L. Bray Chair in Urology
M.D., University of Tennessee Center for Health Science, Memphis, TennesseeB.A., University of Tennessee, Knoxville, Tennessee
Office Address
A-1302 MCN
TN 2765
Kordan Y, Chang SS, Salem S, Cookson MS, Clark PE, Davis R, Herrell SD, Baumgartner R, Phillips S, Smith JA, Barocas DA. Pathological stage T2 subgroups to predict biochemical recurrence after prostatectomy. J. Urol [print-electronic]. 2009 Nov; 182(5): 2291-5. PMID: 19758638, PII: S0022-5347(09)01744-3, DOI: 10.1016/j.juro.2009.07.020, ISSN: 1527-3792.

Lowrance WT, Rumohr JA, Clark PE, Chang SS, Smith JA, Cookson MS. Urinary diversion trends at a high volume, single American tertiary care center. J. Urol [print-electronic]. 2009 Nov; 182(5): 2369-74. PMID: 19758613, PII: S0022-5347(09)01750-9, DOI: 10.1016/j.juro.2009.07.026, ISSN: 1527-3792.

Barocas DA, Patel SG, Chang SS, Clark PE, Smith JA, Cookson MS. Outcomes of patients undergoing radical cystoprostatectomy for bladder cancer with prostatic involvement on final pathology. BJU Int [print-electronic]. 2009 Oct; 104(8): 1091-7. PMID: 19389006, PII: BJU8558, DOI: 10.1111/j.1464-410X.2009.08558.x, ISSN: 1464-410X.

Patel SG, Cookson MS, Barocas DA, Clark PE, Smith JA, Chang SS. Risk factors for urothelial carcinoma of the prostate in patients undergoing radical cystoprostatectomy for bladder cancer. BJU Int [print-electronic]. 2009 Oct; 104(7): 934-7. PMID: 19338554, PII: BJU8525, DOI: 10.1111/j.1464-410X.2009.08525.x, ISSN: 1464-410X.

Stepanovic SZ, Potet F, Petersen CI, Smith JA, Meiler J, Balser JR, Kupershmidt S. The evolutionarily conserved residue A653 plays a key role in HERG channel closing. J. Physiol. (Lond.) [print-electronic]. 2009 Jun 6/1/2009; 587(Pt 11): 2555-66. PMID: 19406877, PMCID: PMC2714020, PII: jphysiol.2008.166694, DOI: 10.1113/jphysiol.2008.166694, ISSN: 1469-7793.

Mitchell RE, Lee BT, Cookson MS, Barocas DA, Duke Herrell S, Clark PE, Smith JA, Chang SS. Radical nephrectomy surgical outcomes in the University HealthSystem Consortium Data Base: Impact of hospital case volume, hospital size, and geographic location on 40,000 patients. Cancer. 2009 Jun 6/1/2009; 115(11): 2447-52. PMID: 19309750, DOI: 10.1002/cncr.24292, ISSN: 0008-543X.

Fowke JH, Motley SS, Smith JA, Cookson MS, Concepcion R, Chang SS, Byerly S. Association of nonsteroidal anti-inflammatory drugs, prostate specific antigen and prostate volume. J. Urol [print-electronic]. 2009 May; 181(5): 2064-70. PMID: 19286210, PMCID: PMC2679527, PII: S0022-5347(09)00053-6, DOI: 10.1016/j.juro.2009.01.031, ISSN: 1527-3792.

Milhoua PM, Miller NL, Cookson MS, Chang SS, Smith JA, Herrell SD. Primary endoscopic management versus open revision of ureteroenteric anastomotic strictures after urinary diversion--single institution contemporary series. J. Endourol. 2009 Mar; 23(3): 551-5. PMID: 19193136, PII: 10.1089/end.2008.0230, DOI: 10.1089/end.2008.0230, ISSN: 1557-900X.

Boudreaux KJ, Chang SS, Lowrance WT, Rumohr JA, Barocas DA, Cookson MS, Smith JA, Clark PE. Comparison of American Joint Committee on Cancer pathologic stage T3a versus T3b urothelial carcinoma: analysis of patient outcomes. Cancer. 2009 Feb 2/15/2009; 115(4): 770-5. PMID: 19152431, DOI: 10.1002/cncr.24110, ISSN: 0008-543X.

Boudreaux KJ, Clark PE, Lowrance WT, Rumohr JA, Barocas DA, Cookson MS, Smith JA, Chang SS. Comparison of american joint committee on cancer pathological stage T2a versus T2b urothelial carcinoma: analysis of patient outcomes in organ confined bladder cancer. J. Urol [print-electronic]. 2009 Feb; 181(2): 540-5; discussion 546. PMID: 19084855, PII: S0022-5347(08)02724-9, DOI: 10.1016/j.juro.2008.10.038, ISSN: 1527-3792.

Coons BJ, Stec AA, Stratton KL, Chang SS, Cookson MS, Duke Herrell S, Smith JA, Clark PE. Prognostic factors in T3b renal cell carcinoma. World J Urol [print-electronic]. 2009 Feb; 27(1): 75-9. PMID: 19039590, PMCID: PMC2963091, DOI: 10.1007/s00345-008-0358-9, ISSN: 1433-8726.

Blum DL, Koyama T, M'Koma AE, Iturregui JM, Martinez-Ferrer M, Uwamariya C, Smith JA, Clark PE, Bhowmick NA. Chemokine markers predict biochemical recurrence of prostate cancer following prostatectomy. Clin. Cancer Res. 2008 Dec 12/1/2008; 14(23): 7790-7. PMID: 19047106, PMCID: PMC3050736, PII: 14/23/7790, DOI: 10.1158/1078-0432.CCR-08-1716, ISSN: 1078-0432.

Barocas DA, Cowan JE, Smith JA, Carroll PR, . What percentage of patients with newly diagnosed carcinoma of the prostate are candidates for surveillance? An analysis of the CaPSURE database. J. Urol [print-electronic]. 2008 Oct; 180(4): 1330-4; discussion 1334. PMID: 18707731, PII: S0022-5347(08)01550-4, DOI: 10.1016/j.juro.2008.06.019, ISSN: 1527-3792.

Smith JA. Radical prostatectomy for low risk carcinoma of the prostate. World J Urol [print-electronic]. 2008 Oct; 26(5): 443-6. PMID: 18594827, DOI: 10.1007/s00345-008-0293-9, ISSN: 0724-4983.

Smith JA. The case for open radical cystoprostatectomy and urinary reconstruction. J. Endourol. 2008 Sep; 22(9): 2065-7; discussion 2081, 2083. PMID: 18811544, DOI: 10.1089/end.2008.9743, ISSN: 1557-900X.

Kang C, Tian C, Sönnichsen FD, Smith JA, Meiler J, George AL, Vanoye CG, Kim HJ, Sanders CR. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry [print-electronic]. 2008 Aug 8/5/2008; 47(31): 7999-8006. PMID: 18611041, PMCID: PMC2580054, DOI: 10.1021/bi800875q, ISSN: 1520-4995.

Stec AA, Coons BJ, Chang SS, Cookson MS, Herrell SD, Smith JA, Clark PE. Waiting time from initial urological consultation to nephrectomy for renal cell carcinoma--does it affect survival?. J. Urol [print-electronic]. 2008 Jun; 179(6): 2152-7. PMID: 18423724, PMCID: PMC2953870, PII: S0022-5347(08)00258-9, DOI: 10.1016/j.juro.2008.01.111, ISSN: 1527-3792.

Revelo MP, Cookson MS, Chang SS, Shook MF, Smith JA, Shappell SB. Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery. J. Urol. 2008 May; 179(5 Suppl): S27-32. PMID: 18405745, PII: S0022-5347(08)00735-0, DOI: 10.1016/j.juro.2008.03.134, ISSN: 1527-3792.

Chan RC, Barocas DA, Chang SS, Herrell SD, Clark PE, Baumgartner R, Smith JA, Cookson MS. Effect of a large prostate gland on open and robotically assisted laparoscopic radical prostatectomy. BJU Int. 2008 May; 101(9): 1140-4. PMID: 18399829, PII: BJU7428, DOI: 10.1111/j.1464-410X.2007.07428.x, ISSN: 1464-410X.

Lowrance WT, Rumohr JA, Chang SS, Clark PE, Smith JA, Cookson MS. Contemporary open radical cystectomy: analysis of perioperative outcomes. J. Urol [print-electronic]. 2008 Apr; 179(4): 1313-8; discussion 1318. PMID: 18289578, PII: S0022-5347(07)03124-2, DOI: 10.1016/j.juro.2007.11.084, ISSN: 1527-3792.

Patel SG, Cookson MS, Clark PE, Smith JA, Chang SS. Neovesical-urethral anastomotic stricture after orthotopic urinary diversion: presentation and management. BJU Int [print-electronic]. 2008 Jan; 101(2): 219-22. PMID: 17941923, PII: BJU7237, DOI: 10.1111/j.1464-410X.2007.07237.x, ISSN: 1464-410X.

Smith JA, Vanoye CG, George AL, Meiler J, Sanders CR. Structural models for the KCNQ1 voltage-gated potassium channel. Biochemistry [print-electronic]. 2007 Dec 12/11/2007; 46(49): 14141-52. PMID: 17999538, PMCID: PMC2565492, DOI: 10.1021/bi701597s, ISSN: 0006-2960.

Smith JA, Chan RC, Chang SS, Herrell SD, Clark PE, Baumgartner R, Cookson MS. A comparison of the incidence and location of positive surgical margins in robotic assisted laparoscopic radical prostatectomy and open retropubic radical prostatectomy. J. Urol [print-electronic]. 2007 Dec; 178(6): 2385-9; discussion 2389. PMID: 17936849, PII: S0022-5347(07)01979-9, DOI: 10.1016/j.juro.2007.08.008, ISSN: 1527-3792.

Barbieri CE, Lee B, Cookson MS, Bingham J, Clark PE, Smith JA, Chang SS. Association of procedure volume with radical cystectomy outcomes in a nationwide database. J. Urol [print-electronic]. 2007 Oct; 178(4 Pt 1): 1418-21; discussion 1421. PMID: 17706712, PII: S0022-5347(07)01427-9, DOI: 10.1016/j.juro.2007.05.156, ISSN: 0022-5347.

Schachter LR, Cookson MS, Chang SS, Smith JA, Dietrich MS, Jayaram G, Herrell SD. Second prize: frequency of benign renal cortical tumors and histologic subtypes based on size in a contemporary series: what to tell our patients. J. Endourol. 2007 Aug; 21(8): 819-23. PMID: 17867935, DOI: 10.1089/end.2006.9937, ISSN: 0892-7790.

Lowrance WT, Cookson MS, Clark PE, Smith JA, Chang SS. Assessing retroperitoneal lymphadenectomy experience in United States urological residency programs. J. Urol [print-electronic]. 2007 Aug; 178(2): 500-3; discussion 503. PMID: 17561148, PII: S0022-5347(07)00832-4, DOI: 10.1016/j.juro.2007.03.139, ISSN: 0022-5347.

Fowke JH, Motley SS, Wills M, Cookson MS, Concepcion RS, Eckstein CW, Chang SS, Smith JA. Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia. Cancer Causes Control [print-electronic]. 2007 May; 18(4): 375-84. PMID: 17334811, DOI: 10.1007/s10552-007-0119-x, ISSN: 0957-5243.

Kaufman MR, Baumgartner RG, Anderson LW, Smith JA, Chang SS, Herrell SD, Cookson MS. The evidence-based pathway for peri-operative management of open and robotically assisted laparoscopic radical prostatectomy. BJU Int [print-electronic]. 2007 May; 99(5): 1103-8. PMID: 17309550, PII: BJU6777, DOI: 10.1111/j.1464-410X.2007.06777.x, ISSN: 1464-4096.

Smith JA, Bray WL. Re: Metastatic prostate cancer-does treatment of the primary tumor matter?. Eur. Urol. 2007 Mar; 51(3): 852-3. PMID: 17421064, ISSN: 0302-2838.

Nelson B, Kaufman M, Broughton G, Cookson MS, Chang SS, Herrell SD, Baumgartner RG, Smith JA. Comparison of length of hospital stay between radical retropubic prostatectomy and robotic assisted laparoscopic prostatectomy. J. Urol. 2007 Mar; 177(3): 929-31. PMID: 17296378, PII: S0022-5347(06)02730-3, DOI: 10.1016/j.juro.2006.10.070, ISSN: 0022-5347.

Jung C, Cookson MS, Chang SS, Smith JA, Dietrich MS, Teng M. Toxicity following high-dose salvage radiotherapy after radical prostatectomy. BJU Int [print-electronic]. 2007 Mar; 99(3): 529-33. PMID: 17155969, PII: BJU6661, DOI: 10.1111/j.1464-410X.2006.06661.x, ISSN: 1464-4096.

Fowke JH, Motley SS, Cookson MS, Concepcion R, Chang SS, Wills ML, Smith JA. The association between body size, prostate volume and prostate-specific antigen. Prostate Cancer Prostatic Dis [print-electronic]. 2007; 10(2): 137-42. PMID: 17179979, PII: 4500924, DOI: 10.1038/sj.pcan.4500924, ISSN: 1365-7852.

Girasole CR, Cookson MS, Smith JA, Ivey BS, Roth BJ, Chang SS. Sperm banking: use and outcomes in patients treated for testicular cancer. BJU Int [print-electronic]. 2007 Jan; 99(1): 33-6. PMID: 17034492, PII: BJU6537, DOI: 10.1111/j.1464-410X.2006.06537.x, ISSN: 1464-4096.

Chang SS, Smith JA, Herrell SD, Cookson MS. Assessing urinary diversion experience in urologic residency programs-are we adequately training the next generation?. J. Urol. 2006 Aug; 176(2): 691-3. PMID: 16813920, PII: S0022-5347(06)00779-8, DOI: 10.1016/j.juro.2006.03.096, ISSN: 0022-5347.

Smith JA. Radical prostatectomy-which patients benefit most from surgery? [editorial]. J. Urol. 2006 Aug; 176(2): 437. PMID: 16813860, PII: S0022-5347(06)01221-3, DOI: 10.1016/j.juro.2006.05.019, ISSN: 0022-5347.

Hassan JM, Cookson MS, Smith JA, Chang SS. Patterns of initial transitional cell recurrence in patients after cystectomy. J. Urol. 2006 Jun; 175(6): 2054-7. PMID: 16697802, PII: S0022-5347(06)00323-5, DOI: 10.1016/S0022-5347(06)00323-5, ISSN: 0022-5347.

Nelson BA, Shappell SB, Chang SS, Wells N, Farnham SB, Smith JA, Cookson MS. Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer. BJU Int. 2006 Jun; 97(6): 1169-72. PMID: 16686706, PII: BJU6148, DOI: 10.1111/j.1464-410X.2006.06148.x, ISSN: 1464-4096.

Nelson BA, Chang SS, Cookson MS, Smith JA. Morbidity and efficacy of genitofemoral nerve grafts with radical retropubic prostatectomy. Urology [print-electronic]. 2006 Apr; 67(4): 789-92. PMID: 16584763, PII: S0090-4295(05)01459-7, DOI: 10.1016/j.urology.2005.10.004, ISSN: 1527-9995.

Girasole CR, Cookson MS, Putzi MJ, Chang SS, Smith JA, Wells N, Oppenheimer JR, Shappell SB. Significance of atypical and suspicious small acinar proliferations, and high grade prostatic intraepithelial neoplasia on prostate biopsy: implications for cancer detection and biopsy strategy. J. Urol. 2006 Mar; 175(3 Pt 1): 929-33; discussion 933. PMID: 16469583, PII: S0022-5347(05)00338-1, DOI: 10.1016/S0022-5347(05)00338-1, ISSN: 0022-5347.

Kaufman MR, Smith JA, Baumgartner RG, Wells N, Chang SS, Herrell SD, Cookson MS. Positive influence of robotically assisted laparoscopic prostatectomy on the collaborative-care pathway for open radical prostatectomy. BJU Int. 2006 Mar; 97(3): 473-5. PMID: 16469010, PII: BJU5993, DOI: 10.1111/j.1464-410X.2005.05993.x, ISSN: 1464-4096.

Farnham SB, Webster TM, Herrell SD, Smith JA. Intraoperative blood loss and transfusion requirements for robotic-assisted radical prostatectomy versus radical retropubic prostatectomy. Urology. 2006 Feb; 67(2): 360-3. PMID: 16461085, PII: S0090-4295(05)01185-4, DOI: 10.1016/j.urology.2005.08.029, ISSN: 1527-9995.

Smith JA, Herrell SD. Robotic-assisted laparoscopic prostatectomy: do minimally invasive approaches offer significant advantages?. J. Clin. Oncol. 2005 Nov 11/10/2005; 23(32): 8170-5. PMID: 16278469, PII: 23/32/8170, DOI: 10.1200/JCO.2005.03.1963, ISSN: 0732-183X.

Herrell SD, Smith JA. Robotic-assisted laparoscopic prostatectomy: what is the learning curve?. Urology. 2005 Nov; 66(5 Suppl): 105-7. PMID: 16194715, PII: S0090-4295(05)00938-6, DOI: 10.1016/j.urology.2005.06.084, ISSN: 1527-9995.

Webster TM, Herrell SD, Chang SS, Cookson MS, Baumgartner RG, Anderson LW, Smith JA. Robotic assisted laparoscopic radical prostatectomy versus retropubic radical prostatectomy: a prospective assessment of postoperative pain. J. Urol. 2005 Sep; 174(3): 912-4; discussion 914. PMID: 16093986, PII: S0022-5347(01)68445-3, DOI: 10.1097/01.ju.0000169455.25510.ff, ISSN: 0022-5347.

Chang SS, Cole E, Smith JA, Baumgartner R, Wells N, Cookson MS. Safely reducing length of stay after open radical retropubic prostatectomy under the guidance of a clinical care pathway. Cancer. 2005 Aug 8/15/2005; 104(4): 747-51. PMID: 15999365, DOI: 10.1002/cncr.21233, ISSN: 0008-543X.

Chang SS, Ivey B, Smith JA, Roth BJ, Cookson MS. Performance-enhancing supplement use in patients with testicular cancer. Urology. 2005 Aug; 66(2): 242-5. PMID: 16098349, PII: S0090-4295(05)00638-2, DOI: 10.1016/j.urology.2005.04.067, ISSN: 1527-9995.

Farnham SB, Mason SE, Smith JA. Metastatic testicular seminoma to the prostate. Urology. 2005 Jul; 66(1): 195. PMID: 16009406, PII: S0090-4295(05)00169-X, DOI: 10.1016/j.urology.2005.01.058, ISSN: 1527-9995.

Parekh DJ, Cookson MS, Chapman W, Harrell F, Wells N, Chang SS, Smith JA. Renal cell carcinoma with renal vein and inferior vena caval involvement: clinicopathological features, surgical techniques and outcomes. J. Urol. 2005 Jun; 173(6): 1897-902. PMID: 15879771, PII: S0022-5347(05)60167-X, DOI: 10.1097/01.ju.0000158459.42658.95, ISSN: 0022-5347.

Herrell SD, Smith JA. Laparoscopic and robotic radical prostatectomy: what are the real advantages?. BJU Int. 2005 Jan; 95(1): 3-4. PMID: 15638882, PII: BJU5235, DOI: 10.1111/j.1464-410X.2005.05235.x, ISSN: 1464-4096.

Chang SS, Benson MC, Campbell SC, Crook J, Dreicer R, Evans CP, Hall MC, Higano C, Kelly WK, Sartor O, Smith JA, . Society of Urologic Oncology position statement: redefining the management of hormone-refractory prostate carcinoma. Cancer. 2005 Jan 1/1/2005; 103(1): 11-21. PMID: 15558815, DOI: 10.1002/cncr.20726.

Smith JA. Robotically assisted laparoscopic prostatectomy: an assessment of its contemporary role in the surgical management of localized prostate cancer. Am. J. Surg. 2004 Oct; 188(4A Suppl): 63S-67S. PMID: 15476654, PII: S0002-9610(04)00323-X, DOI: 10.1016/j.amjsurg.2004.08.006, ISSN: 0002-9610.

Chang SS, Alberts GL, Smith JA, Cookson MS. Ileal conduit urinary diversion in patients with previous history of abdominal/pelvic irradiation. World J Urol [print-electronic]. 2004 Oct; 22(4): 272-6. PMID: 15448995, DOI: 10.1007/s00345-004-0446-4, ISSN: 0724-4983.

Hassan JM, Cookson MS, Smith JA, Chang SS. Urethral recurrence in patients following orthotopic urinary diversion. J. Urol. 2004 Oct; 172(4 Pt 1): 1338-41. PMID: 15371836, PII: 00005392-200410000-00027, ISSN: 0022-5347.

Hassan JM, Cookson MS, Smith JA, Johnson DL, Chang SS. Outcomes in patients with pathological carcinoma in situ only disease at radical cystectomy. J. Urol. 2004 Sep; 172(3): 882-4. PMID: 15310989, PII: S0022-5347(05)61513-3, DOI: 10.1097/01.ju.0000136294.15938.3d, ISSN: 0022-5347.

Nelson BA, Cookson MS, Smith JA, Chang SS. Complications of inguinal and pelvic lymphadenectomy for squamous cell carcinoma of the penis: a contemporary series. J. Urol. 2004 Aug; 172(2): 494-7. PMID: 15247712, PII: S0022-5347(05)61668-0, DOI: 10.1097/01.ju.0000131453.52463.8f, ISSN: 0022-5347.

Shuford MD, Cookson MS, Chang SS, Shintani AK, Tsiatis A, Smith JA, Shappell SB. Adverse prognostic significance of capsular incision with radical retropubic prostatectomy. J. Urol. 2004 Jul; 172(1): 119-23. PMID: 15201750, PII: S0022-5347(05)61828-9, DOI: 10.1097/, ISSN: 0022-5347.

Kasper S, Smith JA. Genetically modified mice and their use in developing therapeutic strategies for prostate cancer. J. Urol. 2004 Jul; 172(1): 12-9. PMID: 15201729, PII: S0022-5347(05)61807-1, DOI: 10.1097/01.ju.0000132122.93436.aa, ISSN: 0022-5347.

Farnham SB, Cookson MS, Alberts G, Smith JA, Chang SS. Benefit of radical cystectomy in the elderly patient with significant co-morbidities. Urol. Oncol. 2004 May; 22(3): 178-81. PMID: 15271311, PII: S1078143903002655, DOI: 10.1016/j.urolonc.2003.12.005, ISSN: 1078-1439.

Chang SS, Duong DT, Wells N, Cole EE, Smith JA, Cookson MS. Predicting blood loss and transfusion requirements during radical prostatectomy: the significant negative impact of increasing body mass index. J. Urol. 2004 May; 171(5): 1861-5. PMID: 15076294, PII: S0022-5347(05)62262-8, DOI: 10.1097/01.ju.0000120441.96995.e3, ISSN: 0022-5347.

Shuford MD, McDougall EM, Chang SS, LaFleur BJ, Smith JA, Cookson MS. Complications of contemporary radical nephrectomy: comparison of open vs. laparoscopic approach. Urol. Oncol. 2004 Mar; 22(2): 121-6. PMID: 15082009, PII: S1078143903001376, DOI: 10.1016/S1078-1439(03)00137-6, ISSN: 1078-1439.

Chang SS, Jacobs B, Wells N, Smith JA, Cookson MS. Increased body mass index predicts increased blood loss during radical cystectomy. J. Urol. 2004 Mar; 171(3): 1077-9. PMID: 14767274, PII: S0022-5347(05)62417-2, DOI: 10.1097/01.ju.0000113229.45185.e5, ISSN: 0022-5347.

Revelo MP, Cookson MS, Chang SS, Shook MF, Smith JA, Shappell SB. Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery. J. Urol. 2004 Feb; 171(2 Pt 1): 646-51. PMID: 14713778, DOI: 10.1097/01.ju.0000107380.40481.bc, ISSN: 0022-5347.

Halasa NB, Whitlock JA, McCurley TL, Smith JA, Zhu Q, Ochs H, Dermody TS, Crowe JE. Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein. Clin. Infect. Dis [print-electronic]. 2003 Nov 11/15/2003; 37(10): e136-41. PMID: 14583885, PII: CID31173, DOI: 10.1086/379126, ISSN: 1537-6591.

Cookson MS, Dutta SC, Chang SS, Clark T, Smith JA, Wells N. Health related quality of life in patients treated with radical cystectomy and urinary diversion for urothelial carcinoma of the bladder: development and validation of a new disease specific questionnaire. J. Urol. 2003 Nov; 170(5): 1926-30. PMID: 14532809, PII: S0022-5347(05)62966-7, DOI: 10.1097/01.ju.0000092830.03247.ef, ISSN: 0022-5347.

Chang SS, Hassan JM, Cookson MS, Wells N, Smith JA. Delaying radical cystectomy for muscle invasive bladder cancer results in worse pathological stage. J. Urol. 2003 Oct; 170(4 Pt 1): 1085-7. PMID: 14501697, DOI: 10.1097/, ISSN: 0022-5347.

Baldwin DD, Dunbar JA, Parekh DJ, Wells N, Shuford MD, Cookson MS, Smith JA, Herrell SD, Chang SS, McDougall EM. Single-center comparison of purely laparoscopic, hand-assisted laparoscopic, and open radical nephrectomy in patients at high anesthetic risk. J. Endourol. 2003 Apr; 17(3): 161-7. PMID: 12803988, DOI: 10.1089/089277903321618725, ISSN: 0892-7790.

Chang SS, Smith JA, Cookson MS. Decreasing blood loss in patients treated with radical cystectomy: a prospective randomizes trial using a new stapling device. J. Urol. 2003 Mar; 169(3): 951-4. PMID: 12576820, PII: S0022-5347(05)63862-1, DOI: 10.1097/, ISSN: 0022-5347.

Clark T, Parekh DJ, Cookson MS, Chang SS, Smith ER, Wells N, Smith J. Randomized prospective evaluation of extended versus limited lymph node dissection in patients with clinically localized prostate cancer. J. Urol. 2003 Jan; 169(1): 145-7; discussion 147. PMID: 12478123, PII: S0022-5347(05)64055-4, DOI: 10.1097/01.ju.0000039647.16278.17, ISSN: 0022-5347.

Cookson MS, Chang SS, Wells N, Parekh DJ, Smith JA. Complications of radical cystectomy for nonmuscle invasive disease: comparison with muscle invasive disease. J. Urol. 2003 Jan; 169(1): 101-4. PMID: 12478113, PII: S0022-5347(05)64045-1, DOI: 10.1097/01.ju.0000039521.77948.f9, ISSN: 0022-5347.

Adkins KL, Chang SS, Cookson MS, Smith JA. Partial nephrectomy safely preserves renal function in patients with a solitary kidney. J. Urol. 2003 Jan; 169(1): 79-81. PMID: 12478108, PII: S0022-5347(05)64040-2, DOI: 10.1097/01.ju.0000037112.65243.1e, ISSN: 0022-5347.

Parekh DJ, Jung C, Roberts R, Shappell S, Smith JA. Primary neuroendocrine carcinoma of the urethra. Urology. 2002 Dec; 60(6): 1111. PMID: 12475683, PII: S0090429502019921, ISSN: 1527-9995.

Parekh DJ, Clark T, O'Connor J, Jung C, Chang SS, Cookson M, Smith JA. Orthotopic neobladder following radical cystectomy in patients with high perioperative risk and co-morbid medical conditions. J. Urol. 2002 Dec; 168(6): 2454-6. PMID: 12441938, PII: S0022-5347(05)64166-3, DOI: 10.1097/01.ju.0000035645.96508.42, ISSN: 0022-5347.

Baumgartner RG, Wells N, Chang SS, Cookson MS, Smith JA. Causes of increased length of stay following radical cystectomy. Urol Nurs. 2002 Oct; 22(5): 319-23, 339. PMID: 12432717, ISSN: 1053-816X.

Chang SS, Cole E, Cookson MS, Peterson M, Smith JA. Preservation of the anterior vaginal wall during female radical cystectomy with orthotopic urinary diversion: technique and results. J. Urol. 2002 Oct; 168(4 Pt 1): 1442-5. PMID: 12352414, DOI: 10.1097/01.ju.0000030700.53228.aa, ISSN: 0022-5347.

Grossklaus DJ, Smith JA, Shappell SB, Coffey CS, Chang SS, Cookson MS. The free/total prostate-specific antigen ratio (%fPSA) is the best predictor of tumor involvement in the radical prostatectomy specimen among men with an elevated PSA. Urol. Oncol. 2002 Sep; 7(5): 195-8. PMID: 12644216, PII: S1078143902001904, ISSN: 1078-1439.

Jack GS, Cookson MS, Coffey CS, Vader V, Roberts RL, Chang SS, Smith JA, Shappell SB. Pathological parameters of radical prostatectomy for clinical stages T1c versus T2 prostate adenocarcinoma: decreased pathological stage and increased detection of transition zone tumors. J. Urol. 2002 Aug; 168(2): 519-24. PMID: 12131301, PII: S0022-5347(05)64671-X, ISSN: 0022-5347.

Dutta SC, Chang SC, Coffey CS, Smith JA, Jack G, Cookson MS. Health related quality of life assessment after radical cystectomy: comparison of ileal conduit with continent orthotopic neobladder. J. Urol. 2002 Jul; 168(1): 164-7. PMID: 12050514, ISSN: 0022-5347.

Chang SS, Cole E, Smith JA, Cookson MS. Pathological findings of gynecologic organs obtained at female radical cystectomy. J. Urol. 2002 Jul; 168(1): 147-9. PMID: 12050510, PII: S0022-5347(05)64849-5, ISSN: 0022-5347.

Chang SS, Smith JA, Girasole C, Baumgartner RG, Roth BJ, Cookson MS. Beneficial impact of a clinical care pathway in patients with testicular cancer undergoing retroperitoneal lymph node dissection. J. Urol. 2002 Jul; 168(1): 87-92. PMID: 12050498, PII: S0022-5347(05)64837-9, ISSN: 0022-5347.

Smith JA. Outcome after radical prostatectomy depends on surgical technique but not approach. Curr Urol Rep. 2002 Jun; 3(3): 179-81. PMID: 12084186, ISSN: 1527-2737.

Chang SS, Cookson MS, Baumgartner RG, Wells N, Smith JA. Analysis of early complications after radical cystectomy: results of a collaborative care pathway. J. Urol. 2002 May; 167(5): 2012-6. PMID: 11956429, PII: S0022-5347(05)65074-4, ISSN: 0022-5347.

Chang SS, Cookson MS, Hassan JM, Wells N, Smith JA. Routine postoperative intensive care monitoring is not necessary after radical cystectomy. J. Urol. 2002 Mar; 167(3): 1321-4. PMID: 11832723, PII: S0022-5347(05)65291-3, ISSN: 0022-5347.

Nixon RG, Chang SS, Lafleur BJ, Smith JA JA, Cookson MS. Carcinoma in situ and tumor multifocality predict the risk of prostatic urethral involvement at radical cystectomy in men with transitional cell carcinoma of the bladder. J. Urol. 2002 Feb; 167(2 Pt 1): 502-5. PMID: 11792906, ISSN: 0022-5347.

Smith JA, Lumley MA, Longo DJ. Contrasting emotional approach coping with passive coping for chronic myofascial pain. Ann Behav Med. 2002; 24(4): 326-35. PMID: 12434944, ISSN: 0883-6612.

Chang SS, Baumgartner RG, Wells N, Cookson MS, Smith JA. Causes of increased hospital stay after radical cystectomy in a clinical pathway setting. J. Urol. 2002 Jan; 167(1): 208-11. PMID: 11743307, PII: S0022-5347(05)65414-6, ISSN: 0022-5347.

Pietrow PK, Parekh DJ, Smith JA, Shyr Y, Cookson MS. Health related quality of life assessment after radical prostatectomy in men with prostate specific antigen only recurrence. J. Urol. 2001 Dec; 166(6): 2286-90. PMID: 11696753, ISSN: 0022-5347.

Chang SS, Alberts G, Wells N, Smith JA, Cookson MS. Intrarectal lidocaine during transrectal prostate biopsy: results of a prospective double-blind randomized trial. J. Urol. 2001 Dec; 166(6): 2178-80. PMID: 11696730, PII: S0022-5347(05)65529-2, ISSN: 0022-5347.

Chang SS, Smith JA, Wells N, Peterson M, Kovach B, Cookson MS. Estimated blood loss and transfusion requirements of radical cystectomy. J. Urol. 2001 Dec; 166(6): 2151-4. PMID: 11696725, PII: S0022-5347(05)65524-3, ISSN: 0022-5347.

Chang SS, Peterson M, Smith JA. Intraoperative nerve stimulation predicts postoperative potency. Urology. 2001 Oct; 58(4): 594-7. PMID: 11597546, PII: S0090-4295(01)01310-3, ISSN: 1527-9995.

Chang SS, Alberts G, Cookson MS, Smith JA. Radical cystectomy is safe in elderly patients at high risk. J. Urol. 2001 Sep; 166(3): 938-41. PMID: 11490250, PII: S0022-5347(05)65868-5, ISSN: 0022-5347.

Dutta SC, Smith JA, Shappell SB, Coffey CS, Chang SS, Cookson MS. Clinical under staging of high risk nonmuscle invasive urothelial carcinoma treated with radical cystectomy. J. Urol. 2001 Aug; 166(2): 490-3. PMID: 11458053, PII: S0022-5347(05)65969-1, ISSN: 0022-5347.

Pietrow PK, Smith JA. Laser treatment for invasive and noninvasive carcinoma of the bladder. J. Endourol. 2001 May; 15(4): 415-8; discussion 425. PMID: 11394455, DOI: 10.1089/089277901300189466, ISSN: 0892-7790.

Grossklaus DJ, Shappell SB, Gautam S, Smith JA, Cookson MS. Ratio of free-to-total prostate specific antigen correlates with tumor volume in patients with increased prostate specific antigen. J. Urol. 2001 Feb; 165(2): 455-8. PMID: 11176395, PII: S0022-5347(05)66721-3, DOI: 10.1097/00005392-200102000-00024, ISSN: 0022-5347.

Holzbeierlein J, Peterson M, Smith JA JR. Variability of results of cavernous nerve stimulation during radical prostatectomy. J. Urol. 2001 Jan; 165(1): 108-10. PMID: 11125376, ISSN: 0022-5347.

Jack GS, Brash AR, Olson SJ, Manning S, Coffey CS, Smith JA, Shappell SB. Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: correlation with grade and expression in high-grade prostatic intraepithelial neoplasia. Hum. Pathol. 2000 Sep; 31(9): 1146-54. PMID: 11014584, PII: S0046-8177(00)60368-4, DOI: 10.1053/hupa.2000.16670, ISSN: 0046-8177.

Parekh DJ, Gilbert WB, Koch MO, Smith JA. Continent urinary reconstruction versus ileal conduit: a contemporary single-institution comparison of perioperative morbidity and mortality. Urology. 2000 Jun; 55(6): 852-5. PMID: 10840090, PII: S0090429599006196, ISSN: 0090-4295.

Grossklaus DJ, Holzbeierlein JM, Roth BJ, Smith JA. Abnormal mammogram as the presenting sign of renal cell carcinoma. J. Urol. 2000 Apr; 163(4): 1239-40. PMID: 10737507, PII: S0022-5347(05)67734-8, ISSN: 0022-5347.

Gilbert WB, Smith JA. Blood use strategies in urologic surgery. Urology. 2000 Apr; 55(4): 461-7. PMID: 10736484, PII: S0090-4295(99)00534-8, ISSN: 1527-9995.

Holzbeierlein JM, Smith JA. Radical prostatectomy and collaborative care pathways. Semin. Urol. Oncol. 2000 Feb; 18(1): 60-5. PMID: 10719934, ISSN: 1081-0943.

Holzbeierlein JM, Smith JA. Surgical management of noninvasive bladder cancer (stages Ta/T1/CIS). Urol. Clin. North Am. 2000 Feb; 27(1): 15-24, vii. PMID: 10696241, ISSN: 0094-0143.

Smith JA, Reed RB, Francis SH, Grimes K, Corbin JD. Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase. J. Biol. Chem. 2000 Jan 1/7/2000; 275(1): 154-8. PMID: 10617599, ISSN: 0021-9258.

Franke JJ, Gilbert WB, Grier J, Koch MO, Shyr Y, Smith JA. Early post-prostatectomy pelvic floor biofeedback. J. Urol. 2000 Jan; 163(1): 191-3. PMID: 10604344, ISSN: 0022-5347.

Parekh DJ, Gilbert WB, Smith JA. Functional lower urinary tract voiding outcomes after cystectomy and orthotopic neobladder. J. Urol. 2000 Jan; 163(1): 56-8; discussion 58. PMID: 10604313, PII: S0022-5347(05)67971-2, ISSN: 0022-5347.

Ead DN, Koch M, Smith JA. Is invasive anesthetic monitoring necessary during radical prostatectomy?. Prostate Cancer Prostatic Dis. 1999 Dec; 2(5/6): 282-4. PMID: 12497175, PII: 4500376, DOI: 10.1038/sj.pcan.4500376, ISSN: 1476-5608.

Smith JA, Soloway MS, Young MJ. Complications of advanced prostate cancer. Urology. 1999 Dec; 54(6A Suppl): 8-14. PMID: 10606278, ISSN: 0090-4295.

Koch MO, Miller DA, Butler R, Lebos L, Collings D, Smith JA. Are we selecting the right patients for treatment of localized prostate cancer? Results of an actuarial analysis. Urology. 1998 Feb; 51(2): 197-202. PMID: 9495697, PII: S0090-4295(97)00622-5, ISSN: 0090-4295.

Smith JA. Surgical management of superficial bladder cancer (stages Ta/T1/CIS). Semin Surg Oncol. 1997 Sep; 13(5): 328-34. PMID: 9259088, PII: 10.1002/(SICI)1098-2388(199709/10)13:5<328::AID-SSU6>3.0.CO;2-F, ISSN: 8756-0437.

Smith JA. Definition of treatment failure in patients with prostate cancer: subjective versus objective parameters. Can J Urol. 1997 Jun; 4(2 Supp 1): 68-70. PMID: 12735840, ISSN: 1195-9479.

Smith JA, Lange PH, Janknegt RA, Abbou CC, deGery A. Serum markers as a predictor of response duration and patient survival after hormonal therapy for metastatic carcinoma of the prostate. J. Urol. 1997 Apr; 157(4): 1329-34. PMID: 9120932, PII: S0022-5347(01)64963-2, ISSN: 0022-5347.

Smith JA, Scardino PT, Resnick MI, Hernandez AD, Rose SC, Egger MJ. Transrectal ultrasound versus digital rectal examination for the staging of carcinoma of the prostate: results of a prospective, multi-institutional trial. J. Urol. 1997 Mar; 157(3): 902-6. PMID: 9072596, PII: S0022-5347(01)65079-1, ISSN: 0022-5347.

Smith JA, Crawford ED, Paradelo JC, Blumenstein B, Herschman BR, Grossman HB, Christie DW. Treatment of advanced bladder cancer with combined preoperative irradiation and radical cystectomy versus radical cystectomy alone: a phase III intergroup study. J. Urol. 1997 Mar; 157(3): 805-7; discussion 807. PMID: 9072571, PII: S0022-5347(01)65047-X, ISSN: 0022-5347.

Smith JA, Janknegt RA, Abbou CC, de Gery A. Effect of androgen deprivation therapy on local symptoms and tumour progression in men with metastatic carcinoma of the prostate. Eur. Urol. 1997; 31 Suppl 3: 25-9. PMID: 9101212, ISSN: 0302-2838.

Smith JA. Transrectal ultrasonography for the detection and staging of carcinoma of the prostate. J Clin Ultrasound. 1996 Oct; 24(8): 455-61. PMID: 8884522, PII: 10.1002/(SICI)1097-0096(199610)24:8<455::AID-JCU5>3.0.CO;2-J, DOI: 10.1002/(SICI)1097-0096(199610)24:8<455::AID-JCU5>3.0.CO;2-J, ISSN: 0091-2751.

Smith JA. Management of hot flushes due to endocrine therapy for prostate carcinoma. Oncology (Williston Park, N.Y.). 1996 Sep; 10(9): 1319-22; discussion 1324. PMID: 8882924, PII: 162859, ISSN: 0890-9091.

Koch MO, Smith JA. Blood loss during radical retropubic prostatectomy: is preoperative autologous blood donation indicated?. J. Urol. 1996 Sep; 156(3): 1077-9; discussion 1079. PMID: 8709311, PII: S0022-5347(01)65706-9, ISSN: 0022-5347.

Smith JA, Francis SH, Walsh KA, Kumar S, Corbin JD. Autophosphorylation of type Ibeta cGMP-dependent protein kinase increases basal catalytic activity and enhances allosteric activation by cGMP or cAMP. J. Biol. Chem. 1996 Aug 8/23/1996; 271(34): 20756-62. PMID: 8702828, ISSN: 0021-9258.

Francis SH, Smith JA, Colbran JL, Grimes K, Walsh KA, Kumar S, Corbin JD. Arginine 75 in the pseudosubstrate sequence of type Ibeta cGMP-dependent protein kinase is critical for autoinhibition, although autophosphorylated serine 63 is outside this sequence. J. Biol. Chem. 1996 Aug 8/23/1996; 271(34): 20748-55. PMID: 8702827, ISSN: 0021-9258.

Koch MO, Smith JA. Influence of patient age and co-morbidity on outcome of a collaborative care pathway after radical prostatectomy and cystoprostatectomy. J. Urol. 1996 May; 155(5): 1681-4. PMID: 8627853, PII: S0022-5347(01)66164-0, ISSN: 0022-5347.

Koch MO, Seckin B, Smith JA. Impact of a collaborative care approach to radical cystectomy and urinary reconstruction. J. Urol. 1995 Sep; 154(3): 996-1001. PMID: 7637110, PII: S0022-5347(01)66956-8, ISSN: 0022-5347.

Smith JA. Stage T1c prostate cancer: perspectives on clinical management. Semin. Urol. Oncol. 1995 Aug; 13(3): 238-44. PMID: 8521137, ISSN: 1081-0943.

Koch MO, Smith JA. Clinical outcomes associated with the implementation of a cost-efficient programme for radical retropubic prostatectomy. Br J Urol. 1995 Jul; 76(1): 28-33. PMID: 7648063, ISSN: 0007-1331.

Koch MO, Smith JA. Cost containment in urology. Urology. 1995 Jul; 46(1): 14-24; discussion 24. PMID: 7604475, PII: S0090-4295(99)80152-6, DOI: 10.1016/S0090-4295(99)80152-6, ISSN: 0090-4295.

Milam DF, Smith JA. Laser prostatectomy devices and their tissue effects. J. Endourol. 1995 Apr; 9(2): 85-8. PMID: 7633480, ISSN: 0892-7790.

Smith JA, Bray WL. Commentary on the desired tissue effects for laser treatment of the prostate and how they can best be achieved?. J. Urol. 1995 Jan; 153(1): 2. PMID: 7966773, ISSN: 0022-5347.

Hall MC, Koch MO, Smith JA. Femoral neuropathy complicating urologic abdominopelvic procedures. Urology. 1995 Jan; 45(1): 146-9. PMID: 7817470, ISSN: 0090-4295.

Koch MO, Smith JA. Local recurrence of squamous cell carcinoma of the penis. Urol. Clin. North Am. 1994 Nov; 21(4): 739-43. PMID: 7974902, ISSN: 0094-0143.

Koch MO, Brandell RA, Lin D, Smith JA. The effect of sequential compression devices on intraoperative blood loss during radical prostatectomy. J. Urol. 1994 Oct; 152(4): 1178-9. PMID: 8072088, ISSN: 0022-5347.

Koch MO, Smith JA, Hodge EM, Brandell RA. Prospective development of a cost-efficient program for radical retropubic prostatectomy. Urology. 1994 Sep; 44(3): 311-8. PMID: 8073545, PII: S0090-4295(94)80083-9, ISSN: 0090-4295.

Robertson JB, Koch MO, Kirchner FK, Smith JA. Suboptimal treatment results with the Therasonics lithotriptor. J. Urol. 1994 Aug; 152(2 Pt 1): 317-9. PMID: 8015060, ISSN: 0022-5347.

Smith JA. A prospective comparison of treatments for symptomatic hot flushes following endocrine therapy for carcinoma of the prostate. J. Urol. 1994 Jul; 152(1): 132-4. PMID: 8201642, ISSN: 0022-5347.

Scaletscky R, Koch MO, Eckstein CW, Bicknell SL, Gray GF, Smith JA. Tumor volume and stage in carcinoma of the prostate detected by elevations in prostate specific antigen. J. Urol. 1994 Jul; 152(1): 129-31. PMID: 7515448, ISSN: 0022-5347.

Scaletscky R, Wright JK, Shaw J, Smith JA. Ileal conduit venous varices from portal hypertension as a cause of recurrent, massive hemorrhage: case report and review of the literature. J. Urol. 1994 Feb; 151(2): 417-9. PMID: 8283541, ISSN: 0022-5347.

Smith JA, Francis SH, Corbin JD. Autophosphorylation: a salient feature of protein kinases. Mol. Cell. Biochem. 1993 Nov; 127-128: 51-70. PMID: 7935362, ISSN: 0300-8177.

Smith JA, Scaletsky R. Future directions in tumor marker technology for prostate cancer. Urol. Clin. North Am. 1993 Nov; 20(4): 771-7. PMID: 7505985, ISSN: 0094-0143.

Smith JA. Review: tissue effects of laser energy. J. Endourol. 1993 Oct; 7(5): 389-90. PMID: 8298620, ISSN: 0892-7790.

Scaletscky R, Smith JA. Disease flare with gonadotrophin-releasing hormone (GnRH) analogues. How serious is it?. Drug Saf. 1993 Apr; 8(4): 265-70. PMID: 8481213, ISSN: 0114-5916.

Smith JA. Repeat operations after continent urinary reconstruction. Semin Urol. 1993 Feb; 11(1): 20-2. PMID: 8465124, ISSN: 0730-9147.

Smith JA. Laser surgery for transitional-cell carcinoma. Technique, advantages, and limitations. Urol. Clin. North Am. 1992 Aug; 19(3): 473-83. PMID: 1636232, ISSN: 0094-0143.

Smith JA. Management of localized prostate cancer. Cancer. 1992 Jul 7/1/1992; 70(1 Suppl): 302-6. PMID: 1600491, ISSN: 0008-543X.

Smith JA, Hernandez AD, Wittwer CJ, Avent JM, Greenwood J, Hammond EH, Middleton RG. Long-term follow-up after radical prostatectomy. Identification of prognostic variables. Urol. Clin. North Am. 1991 Aug; 18(3): 473-6. PMID: 1877108, ISSN: 0094-0143.

Taylor SJ, Smith JA, Exton JH. Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit. J. Biol. Chem. 1990 Oct 10/5/1990; 265(28): 17150-6. PMID: 2120213, ISSN: 0021-9258.

Lynch CJ, Taylor SJ, Smith JA, Exton JH. Formation of the high-affinity agonist state of the alpha 1-adrenergic receptor at cold temperatures does not require a G-protein. FEBS Lett. 1988 Feb 2/29/1988; 229(1): 54-8. PMID: 2831091, PII: 0014-5793(88)80796-8, ISSN: 0014-5793.