M. Diana Neely, Ph.D.

Research Associate Professor

diana.neely@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Pediatrics
Education
Ph.D., Biochemistry, Brown University, Providence, Rhode IslandM.S., Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland
Office Address
313 PHV
TN 8645
Publications
Boutté AM, Neely MD, Bird TD, Montine KS, Montine TJ. Diminished taxol/GTP-stimulated tubulin polymerization in diseased region of brain from patients with late-onset or inherited Alzheimer's disease or frontotemporal dementia with parkinsonism linked to chromosome-17 but not individuals with mild cognitive impairment. J. Alzheimers Dis. 2005 Sep; 8(1): 1-6. PMID: 16155344, ISSN: 1387-2877.

Neely MD, Boutte A, Milatovic D, Montine TJ. Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction. Brain Res. 2005 Mar 3/10/2005; 1037(1-2): 90-8. PMID: 15777756, PII: S0006-8993(04)01950-X, DOI: 10.1016/j.brainres.2004.12.027, ISSN: 0006-8993.

Shie FS, Neely MD, Maezawa I, Wu H, Olson SJ, Jürgens G, Montine KS, Montine TJ. Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. Am. J. Pathol. 2004 Apr; 164(4): 1173-81. PMID: 15039206, PMCID: PMC1615328, PII: S0002-9440(10)63205-1, DOI: 10.1016/S0002-9440(10)63205-1, ISSN: 0002-9440.

Swift LL, Zhu MY, Kakkad B, Jovanovska A, Neely MD, Valyi-Nagy K, Roberts RL, Ong DE, Jerome WG. Subcellular localization of microsomal triglyceride transfer protein. J. Lipid Res [print-electronic]. 2003 Oct; 44(10): 1841-9. PMID: 12837846, PII: M300276-JLR200, DOI: 10.1194/jlr.M300276-JLR200, ISSN: 0022-2275.

Picklo MJ, Montine TJ, Amarnath V, Neely MD. Carbonyl toxicology and Alzheimer's disease. Toxicol. Appl. Pharmacol. 2002 Nov 11/1/2002; 184(3): 187-97. PMID: 12460747, PII: S0041008X02995062, ISSN: 0041-008X.

Montine TJ, Neely MD, Quinn JF, Beal MF, Markesbery WR, Roberts LJ, Morrow JD. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic. Biol. Med. 2002 Sep 9/1/2002; 33(5): 620-6. PMID: 12208348, PII: S0891584902008079, ISSN: 0891-5849.

Neely MD, Montine TJ. CSF lipoproteins and Alzheimer's disease. J Nutr Health Aging. 2002; 6(6): 383-91. PMID: 12459889, ISSN: 1279-7707.

Neely MD, Amarnath V, Weitlauf C, Montine TJ. Synthesis and cellular effects of an intracellularly activated analogue of 4-hydroxynonenal. Chem. Res. Toxicol. 2002 Jan; 15(1): 40-7. PMID: 11800596, PII: tx010115w, ISSN: 0893-228X.

Neely MD, Zimmerman L, Picklo MJ, Ou JJ, Morales CR, Montine KS, Amaranth V, Montine TJ. Congeners of N(alpha)-acetyl-L-cysteine but not aminoguanidine act as neuroprotectants from the lipid peroxidation product 4-hydroxy-2-nonenal. Free Radic. Biol. Med. 2000 Nov 11/15/2000; 29(10): 1028-36. PMID: 11084291, PII: S0891-5849(00)00411-1, ISSN: 0891-5849.

Neely MD, Swift LL, Montine TJ. Human, but not bovine, oxidized cerebral spinal fluid lipoproteins disrupt neuronal microtubules. Lipids. 2000 Nov; 35(11): 1249-57. PMID: 11132184, ISSN: 0024-4201.

Bassett CN, Montine KS, Neely MD, Swift LL, Montine TJ. Cerebrospinal fluid lipoproteins in Alzheimer's disease. Microsc. Res. Tech. 2000 Aug 8/15/2000; 50(4): 282-6. PMID: 10936881, PII: 10.1002/1097-0029(20000815)50:4<282::AID-JEMT6>3.0.CO;2-T, DOI: 10.1002/1097-0029(20000815)50:4<282::AID-JEMT6>3.0.CO;2-T, ISSN: 1059-910X.

Bassett CN, Neely MD, Sidell KR, Markesbery WR, Swift LL, Montine TJ. Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo. Lipids. 1999 Dec; 34(12): 1273-80. PMID: 10652986, ISSN: 0024-4201.

Neely MD, Sidell KR, Graham DG, Montine TJ. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin. J. Neurochem. 1999 Jun; 72(6): 2323-33. PMID: 10349841, ISSN: 0022-3042.

Montine KS, Reich E, Neely MD, Sidell KR, Olson SJ, Markesbery WR, Montine TJ. Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype. J. Neuropathol. Exp. Neurol. 1998 May; 57(5): 415-25. PMID: 9596412, ISSN: 0022-3069.

Neely MD, Macaluso E. Motile areas of leech neurites are rich in microfilaments and two actin-binding proteins: gelsolin and profilin. Proc. Biol. Sci. 1997 Nov 11/22/1997; 264(1388): 1701-6. PMID: 9404032, PMCID: PMC1688718, DOI: 10.1098/rspb.1997.0236, ISSN: 0962-8452.

Neely MD, Nicholls JG. Electrical activity, growth cone motility and the cytoskeleton. J. Exp. Biol. 1995 Jul; 198(Pt 7): 1433-46. PMID: 7658186, ISSN: 0022-0949.

Neely MD, Gesemann M. Disruption of microfilaments in growth cones following depolarization and calcium influx. J. Neurosci. 1994 Dec; 14(12): 7511-20. PMID: 7996192, ISSN: 0270-6474.

Masuda-Nakagawa LM, Walz A, Brodbeck D, Neely MD, Grumbacher-Reinert S. Substrate-dependent interactions of leech microglial cells and neurons in culture. J. Neurobiol. 1994 Jan; 25(1): 83-91. PMID: 8113785, DOI: 10.1002/neu.480250108, ISSN: 0022-3034.

Neely MD. Role of substrate and calcium in neurite retraction of leech neurons following depolarization. J. Neurosci. 1993 Mar; 13(3): 1292-301. PMID: 8441011, ISSN: 0270-6474.

Boekelheide K, Eveleth J, Neely MD, Sioussat TM. Microtubule assembly is altered following covalent modification by the n-hexane metabolite 2,5-hexanedione. Adv. Exp. Med. Biol. 1991; 283: 433-42. PMID: 2069017, ISSN: 0065-2598.

Neely MD, Erickson HP, Boekelheide K. HMW-2, the Sertoli cell cytoplasmic dynein from rat testis, is a dimer composed of nearly identical subunits. J. Biol. Chem. 1990 May 5/25/1990; 265(15): 8691-8. PMID: 2140361, ISSN: 0021-9258.

Boekelheide K, Neely MD, Sioussat TM. The Sertoli cell cytoskeleton: a target for toxicant-induced germ cell loss. Toxicol. Appl. Pharmacol. 1989 Dec; 101(3): 373-89. PMID: 2690397, ISSN: 0041-008X.

Neely MD, Boekelheide K. Sertoli cell processes have axoplasmic features: an ordered microtubule distribution and an abundant high molecular weight microtubule-associated protein (cytoplasmic dynein). J. Cell Biol. 1988 Nov; 107(5): 1767-76. PMID: 2972729, PMCID: PMC2115329, ISSN: 0021-9525.