Faculty Appointments
Associate Professor of Pharmacology
Associate Professor of Surgery
Education
Ph.D., Cellular Biology of Cancer, Dublin City University, Dublin, IrelandB.Sc., Biotechnology, Dublin City University, Dublin, Ireland
Office Address
715CA PRB
2220 Pierce Ave
Nashville, TN 37232-6840
2220 Pierce Ave
Nashville, TN 37232-6840
Research Description
The primary interest of my lab is understanding metastasis and identifying ways to target this lethal aspect of cancer. My background is in the area of matrix metalloproteinases (MMPs) and how they contribute to cancer development and progression. I have been especially interested in testing drugs that can inhibit MMPs in cancer models and in understanding why such drugs have not been effective in human cancer patients. Lately, the lab has focused on the Th2 cytokines IL4 and IL13 and their receptors, and how these molecules can influence malignant progression of breast and colon cancers. We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.
Research Keywords
metastasis; colon cancer; breast cancer; interleukins; IL4; IL13; lymphatic metastasis; colitis; proteases; MMPs;
Publications
Hargrove-Wiley E, Fingleton B. Sex Hormones in Breast Cancer Immunity. Cancer Res. 2023 Jan 1/4/2023; 83(1): 12-9. PMID: 36279153, PII: 711843, DOI: 10.1158/0008-5472.CAN-22-1829, ISSN: 1538-7445.
Bindeman WE, Fingleton B. Glycosylation as a regulator of site-specific metastasis. Cancer Metastasis Rev [print-electronic]. 2022 Mar; 41(1): 107-29. PMID: 34967926, PMCID: PMC8930623, PII: 10.1007/s10555-021-10015-1, DOI: 10.1007/s10555-021-10015-1, ISSN: 1573-7233.
Wolf EM, Fingleton B, Hasty AH. The therapeutic potential of TREM2 in cancer. Front Oncol. 2022; 12: 984193. PMID: 36119485, PMCID: PMC9479103, DOI: 10.3389/fonc.2022.984193, ISSN: 2234-943X.
Williams D, Fingleton B. Measurement of Metabolites from Migrating Cells. Methods Mol Biol. 2021; 2294: 143-50. PMID: 33742399, DOI: 10.1007/978-1-0716-1350-4_10, ISSN: 1940-6029.
Banan B, Beckstead JA, Dunavant LE, Sohn Y, Adcock JM, Nomura S, Abumrad N, Goldenring JR, Fingleton B. Development of a novel murine model of lymphatic metastasis. Clin Exp Metastasis [print-electronic]. 2020 Apr; 37(2): 247-55. PMID: 32052231, PMCID: PMC7979265, PII: 10.1007/s10585-020-10025-3, DOI: 10.1007/s10585-020-10025-3, ISSN: 1573-7276.
Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA, . The importance of developing therapies targeting the biological spectrum of metastatic disease. Clin Exp Metastasis [print-electronic]. 2019 Aug; 36(4): 305-9. PMID: 31102066, PMCID: PMC8794535, PII: 10.1007/s10585-019-09972-3, DOI: 10.1007/s10585-019-09972-3, ISSN: 1573-7276.
Williams D, Fingleton B. Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis. Clin Exp Metastasis [print-electronic]. 2019 Jun; 36(3): 211-24. PMID: 31073762, PMCID: PMC6538276, PII: 10.1007/s10585-019-09967-0, DOI: 10.1007/s10585-019-09967-0, ISSN: 1573-7276.
Thompson JJ, Short SP, Parang B, Brown RE, Li C, Ng VH, Saito-Diaz K, Choksi YA, Washington MK, Smith JJ, Fingleton B, Brand T, Lee E, Coffey RJ, Williams CS. Blood vessel epicardial substance (BVES) reduces LRP6 receptor and cytoplasmic -catenin levels to modulate Wnt signaling and intestinal homeostasis. Carcinogenesis [print-electronic]. 2019 Jan 1/23/2019; 40(9): 1086-98. PMID: 30689807, PMCID: PMC8067673, PII: 5299709, DOI: 10.1093/carcin/bgz007, ISSN: 1460-2180.
Fingleton B, Lange K, Caldwell B, Bankaitis KV, . Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example. Clin Exp Metastasis [print-electronic]. 2017 Dec; 34(8): 443-7. PMID: 29484519, PII: 10.1007/s10585-017-9872-8, DOI: 10.1007/s10585-017-9872-8, ISSN: 1573-7276.
Fingleton B. Making Cancer Quiescent: SPDEF De-Cycles Beta-Catenin [editorial]. Gastroenterology [print-electronic]. 2017 Jul; 153(1): 10-2. PMID: 28572010, PII: S0016-5085(17)35683-4, DOI: 10.1053/j.gastro.2017.05.041, ISSN: 1528-0012.
Fingleton B. Matrix metalloproteinases as regulators of inflammatory processes. Biochim. Biophys. Acta [print-electronic]. 2017 May 5/11/2017; PMID: 28502592, PII: S0167-4889(17)30121-0, DOI: 10.1016/j.bbamcr.2017.05.010, ISSN: 0006-3002.
Bankaitis K, Borriello L, Cox T, Lynch C, Zijlstra A, Fingleton B, Gužvic M, Anderson R, Neman J. Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis. Clin. Exp. Metastasis [print-electronic]. 2017 Apr; 34(3-4): 203-13. PMID: 28260197, PII: 10.1007/s10585-017-9842-1, DOI: 10.1007/s10585-017-9842-1, ISSN: 1573-7276.
Bankaitis KV, Fingleton B. Targeting IL4/IL4R for the treatment of epithelial cancer metastasis. Clin. Exp. Metastasis [print-electronic]. 2015 Dec; 32(8): 847-56. PMID: 26385103, PMCID: PMC4651701, PII: 10.1007/s10585-015-9747-9, DOI: 10.1007/s10585-015-9747-9, ISSN: 1573-7276.
Venmar KT, Kimmel DW, Cliffel DE, Fingleton B. IL4 receptor a mediates enhanced glucose and glutamine metabolism to support breast cancer growth. Biochim. Biophys. Acta [print-electronic]. 2015 May; 1853(5): 1219-28. PMID: 25746764, PMCID: PMC4380623, PII: S0167-4889(15)00070-1, DOI: 10.1016/j.bbamcr.2015.02.020, ISSN: 0006-3002.
Shay G, Lynch CC, Fingleton B. Moving targets: Emerging roles for MMPs in cancer progression and metastasis. Matrix Biol [print-electronic]. 2015 May; 44-46: 200-6. PMID: 25652204, PMCID: PMC4564058, PII: S0945-053X(15)00033-5, DOI: 10.1016/j.matbio.2015.01.019, ISSN: 1569-1802.
Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res [print-electronic]. 2015 Apr 4/15/2015; 75(8): 1624-34. PMID: 25691457, PMCID: PMC4401663, PII: 0008-5472.CAN-14-2379, DOI: 10.1158/0008-5472.CAN-14-2379, ISSN: 1538-7445.
Bates AL, Pickup MW, Hallett MA, Dozier EA, Thomas S, Fingleton B. Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases. J. Pathol [print-electronic]. 2015 Apr; 235(5): 773-83. PMID: 25469981, PMCID: PMC4357558, DOI: 10.1002/path.4493, ISSN: 1096-9896.
Mendonsa AM, VanSaun MN, Ustione A, Piston DW, Fingleton BM, Gorden DL. Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver. Mol. Cancer. 2015; 14: 49. PMID: 25880591, PMCID: PMC4351934, PII: 10.1186/s12943-014-0282-0, DOI: 10.1186/s12943-014-0282-0, ISSN: 1476-4598.
Venmar KT, Fingleton B. Lessons from immunology: IL4R directly promotes mammary tumor metastasis. Oncoimmunology. 2014 Oct; 3(9): e955373. PMID: 25941616, PMCID: PMC4292563, PII: 955373, DOI: 10.4161/21624011.2014.955373, ISSN: 2162-4011.
Venmar KT, Carter KJ, Hwang DG, Dozier EA, Fingleton B. IL4 receptor ILR4a regulates metastatic colonization by mammary tumors through multiple signaling pathways. Cancer Res [print-electronic]. 2014 Aug 8/15/2014; 74(16): 4329-40. PMID: 24947041, PMCID: PMC4134711, PII: 0008-5472.CAN-14-0093, DOI: 10.1158/0008-5472.CAN-14-0093, ISSN: 1538-7445.
Petersen CP, Weis VG, Nam KT, Sousa JF, Fingleton B, Goldenring JR. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology [print-electronic]. 2014 Jun; 146(7): 1727-38.e8. PMID: 24534633, PMCID: PMC4035414, PII: S0016-5085(14)00218-2, DOI: 10.1053/j.gastro.2014.02.007, ISSN: 1528-0012.
Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE. Targeting the Wnt pathway in synovial sarcoma models. Cancer Discov [print-electronic]. 2013 Nov; 3(11): 1286-301. PMID: 23921231, PMCID: PMC3823757, PII: 2159-8290.CD-13-0138, DOI: 10.1158/2159-8290.CD-13-0138, ISSN: 2159-8290.
Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS ONE [electronic-print]. 2013; 8(7): e67845. PMID: 23861820, PMCID: PMC3701622, PII: PONE-D-13-14817, DOI: 10.1371/journal.pone.0067845, ISSN: 1932-6203.
Hallett MA, Venmar KT, Fingleton B. Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13. Cancer Res [print-electronic]. 2012 Dec 12/15/2012; 72(24): 6338-43. PMID: 23222300, PMCID: PMC3531868, PII: 0008-5472.CAN-12-3544, DOI: 10.1158/0008-5472.CAN-12-3544, ISSN: 1538-7445.
Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B. Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Lab. Invest [print-electronic]. 2012 Dec; 92(12): 1749-59. PMID: 23044923, PMCID: PMC3510327, PII: labinvest2012141, DOI: 10.1038/labinvest.2012.141, ISSN: 1530-0307.
Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.
Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS ONE [print-electronic]. 2012; 7(12): e51205. PMID: 23251453, PMCID: PMC3521008, PII: PONE-D-12-22965, DOI: 10.1371/journal.pone.0051205, ISSN: 1932-6203.
Thiolloy S, Edwards JR, Fingleton B, Rifkin DB, Matrisian LM, Lynch CC. An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS ONE [print-electronic]. 2012; 7(1): e29862. PMID: 22238668, PMCID: PMC3251607, PII: PONE-D-11-14696, DOI: 10.1371/journal.pone.0029862, ISSN: 1932-6203.
Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res [print-electronic]. 2011 Feb 2/15/2011; 71(4): 1302-12. PMID: 21303973, PMCID: PMC3150168, PII: 0008-5472.CAN-10-3317, DOI: 10.1158/0008-5472.CAN-10-3317, ISSN: 1538-7445.
Koon HB, Fingleton B, Lee JY, Geyer JT, Cesarman E, Parise RA, Egorin MJ, Dezube BJ, Aboulafia D, Krown SE. Phase II AIDS Malignancy Consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma. J. Acquir. Immune Defic. Syndr. 2011 Jan 1/1/2011; 56(1): 64-8. PMID: 21068672, PMCID: PMC3017346, DOI: 10.1097/QAI.0b013e3181fc0141, ISSN: 1944-7884.
Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1273-81. PMID: 20595227, PMCID: PMC3001265, PII: 201001-0001OC, DOI: 10.1164/rccm.201001-0001OC, ISSN: 1535-4970.
Koller FL, Hwang DG, Dozier EA, Fingleton B. Epithelial interleukin-4 receptor expression promotes colon tumor growth. Carcinogenesis [print-electronic]. 2010 Jun; 31(6): 1010-7. PMID: 20176658, PMCID: PMC2878360, PII: bgq044, DOI: 10.1093/carcin/bgq044, ISSN: 1460-2180.
Fingleton B. Inflammatory proteinase slips into tumor cells. Nature medicine. 2010 Feb; 16(2) Sect. 161,3.
Fingleton B, Lynch CC. A new dress code for MMPs: cleavage optional. Dev. Cell. 2010 Jan 1/19/2010; 18(1): 3-4. PMID: 20152171, PII: S1534-5807(10)00004-3, DOI: 10.1016/j.devcel.2010.01.003, ISSN: 1878-1551.
Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445.
Lynch CC, Vargo-Gogola T, Matrisian LM, Fingleton B. Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA. J Oncol [print-electronic]. 2010; 2010: 530745. PMID: 20628524, PMCID: PMC2902104, DOI: 10.1155/2010/530745, ISSN: 1687-8469.
Sinnamon MJ, Carter KJ, Fingleton B, Matrisian LM. Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse. Int J Exp Pathol. 2008 Dec; 89(6): 466-75. PMID: 19134056, PMCID: PMC2669608, PII: IEP621, DOI: 10.1111/j.1365-2613.2008.00621.x, ISSN: 1365-2613.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM. P120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol. Biol. Cell [print-electronic]. 2008 Oct; 19(10): 4110-21. PMID: 18653469, PMCID: PMC2555941, PII: E08-03-0283, DOI: 10.1091/mbc.E08-03-0283, ISSN: 1939-4586.
Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JO. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med. 2008 Sep; 60(3): 718-26. PMID: 18727087, PMCID: PMC2646120, DOI: 10.1002/mrm.21724, ISSN: 1522-2594.
Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, Fingleton B. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res. 2008 Aug 8/1/2008; 68(15): 6251-9. PMID: 18676849, PMCID: PMC2789265, PII: 68/15/6251, DOI: 10.1158/0008-5472.CAN-08-0537, ISSN: 1538-7445.
Sinnamon MJ, Carter KJ, Sims LP, Lafleur B, Fingleton B, Matrisian LM. A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis [print-electronic]. 2008 Apr; 29(4): 880-6. PMID: 18258601, PII: bgn040, DOI: 10.1093/carcin/bgn040, ISSN: 1460-2180.
Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Yull FE, Blackwell TS, Fingleton B. Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol. Cancer Res. 2008 Mar; 6(3): 364-71. PMID: 18337446, PII: 6/3/364, DOI: 10.1158/1541-7786.MCR-07-0309, ISSN: 1541-7786.
Fingleton B. MMPs as therapeutic targets--still a viable option?. Semin. Cell Dev. Biol [print-electronic]. 2008 Feb; 19(1): 61-8. PMID: 17693104, PMCID: PMC2677300, PII: S1084-9521(07)00091-2, DOI: 10.1016/j.semcdb.2007.06.006, ISSN: 1084-9521.
Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Polosukhin VV, Fingleton B, Yull FE, Blackwell TS. Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin. Exp. Metastasis [print-electronic]. 2008; 25(1): 43-51. PMID: 18008176, DOI: 10.1007/s10585-007-9100-z, ISSN: 0262-0898.
Martin MD, Fingleton B, Lynch CC, Wells S, McIntyre JO, Piston DW, Matrisian LM. Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin. Exp. Metastasis [print-electronic]. 2008; 25(8): 877-85. PMID: 18787962, PMCID: PMC2588650, DOI: 10.1007/s10585-008-9206-y, ISSN: 1573-7276.
Stathopoulos GT, Sherrill TP, Cheng DS, Scoggins RM, Han W, Polosukhin VV, Connelly L, Yull FE, Fingleton B, Blackwell TS. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Nov 11/20/2007; 104(47): 18514-9. PMID: 18000061, PMCID: PMC2141808, PII: 0705316104, DOI: 10.1073/pnas.0705316104, ISSN: 1091-6490.
Lepage M, Dow WC, Melchior M, You Y, Fingleton B, Quarles CC, Pépin C, Gore JC, Matrisian LM, McIntyre JO. Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch. Mol Imaging. 2007 Nov; 6(6): 393-403. PMID: 18053410, ISSN: 1535-3508.
Gorden DL, Fingleton B, Crawford HC, Jansen DE, Lepage M, Matrisian LM. Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int. J. Cancer. 2007 Aug 8/1/2007; 121(3): 495-500. PMID: 17417772, DOI: 10.1002/ijc.22594, ISSN: 0020-7136.
Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res. 2007 Jul 7/15/2007; 67(14): 6760-7. PMID: 17638887, PII: 67/14/6760, DOI: 10.1158/0008-5472.CAN-07-0026, ISSN: 0008-5472.
Fingleton B, Carter KJ, Matrisian LM. Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res. 2007 May 5/15/2007; 67(10): 4800-6. PMID: 17510409, PII: 67/10/4800, DOI: 10.1158/0008-5472.CAN-06-4473, ISSN: 0008-5472.
Fingleton B. Molecular targets in metastasis: lessons from genomic approaches. Cancer Genomics Proteomics. 2007 May; 4(3): 211-21. PMID: 17878524, ISSN: 1109-6535.
Schwartz DR, Moin K, Yao B, Matrisian LM, Coussens LM, Bugge TH, Fingleton B, Acuff HB, Sinnamon M, Nassar H, Platts AE, Krawetz SA, Linebaugh BE, Sloane BF. Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol. Cancer Res. 2007 May; 5(5): 443-54. PMID: 17510311, PII: 5/5/443, DOI: 10.1158/1541-7786.MCR-06-0337, ISSN: 1541-7786.
Fingleton B, Powell WC, Crawford HC, Couchman JR, Matrisian LM. A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt). 2007 Feb; 26(1): 22-7. PMID: 17316082, PMCID: PMC3838102, DOI: 10.1089/hyb.2006.028, ISSN: 1554-0014.
Fingleton B. Matrix metalloproteinases as valid clinical targets. Curr. Pharm. Des. 2007; 13(3): 333-46. PMID: 17313364, ISSN: 1873-4286.
Acuff HB, Sinnamon M, Fingleton B, Boone B, Levy SE, Chen X, Pozzi A, Carbone DP, Schwartz DR, Moin K, Sloane BF, Matrisian LM. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res. 2006 Aug 8/15/2006; 66(16): 7968-75. PMID: 16912171, PII: 66/16/7968, DOI: 10.1158/0008-5472.CAN-05-4279, ISSN: 1538-7445.
Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM. Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res. 2006 Jan 1/1/2006; 66(1): 259-66. PMID: 16397239, PMCID: PMC1360653, PII: 66/1/259, DOI: 10.1158/0008-5472.CAN-05-2502, ISSN: 0008-5472.
Fingleton B. Matrix metalloproteinases: roles in cancer and metastasis. Front. Biosci. 2006; 11: 479-91. PMID: 16146745, PII: 1811, ISSN: 1093-9946.
Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int. J. Cancer. 2005 Aug 8/10/2005; 116(1): 52-61. PMID: 15756690, DOI: 10.1002/ijc.20997, ISSN: 0020-7136.
Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell. 2005 May; 7(5): 485-96. PMID: 15894268, PII: S1535-6108(05)00124-8, DOI: 10.1016/j.ccr.2005.04.013, ISSN: 1535-6108.
Harrell PC, McCawley LJ, Fingleton B, McIntyre JO, Matrisian LM. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp. Cell Res [print-electronic]. 2005 Feb 2/15/2005; 303(2): 308-20. PMID: 15652345, PII: S0014-4827(04)00574-9, DOI: 10.1016/j.yexcr.2004.09.020, ISSN: 0014-4827.
Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin. Exp. Metastasis. 2005; 22(2): 185-93. PMID: 16086239, DOI: 10.1007/s10585-005-7453-8, ISSN: 0262-0898.
Fingleton B, Menon R, Carter KJ, Overstreet PD, Hachey DL, Matrisian LM, McIntyre JO. Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Clin. Cancer Res. 2004 Dec 12/1/2004; 10(23): 7865-74. PMID: 15585619, PII: 10/23/7865, DOI: 10.1158/1078-0432.CCR-04-1252, ISSN: 1078-0432.
Gustavson MD, Crawford HC, Fingleton B, Matrisian LM. Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters. Mol. Carcinog. 2004 Nov; 41(3): 125-39. PMID: 15457508, DOI: 10.1002/mc.20049, ISSN: 0899-1987.
Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 2004 Oct; 6(4): 409-21. PMID: 15488763, PII: S1535610804002703, DOI: 10.1016/j.ccr.2004.08.031, ISSN: 1535-6108.
Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat. Genet [print-electronic]. 2004 Sep; 36(9): 969-77. PMID: 15322543, PII: ng1413, DOI: 10.1038/ng1413, ISSN: 1061-4036.
Hulboy DL, Gautam S, Fingleton B, Matrisian LM. The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol. Rep. 2004 Jul; 12(1): 13-7. PMID: 15201952, ISSN: 1021-335X.
McIntyre JO, Fingleton B, Wells KS, Piston DW, Lynch CC, Gautam S, Matrisian LM. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem. J. 2004 Feb 2/1/2004; 377(Pt 3): 617-28. PMID: 14556651, PMCID: PMC1223892, PII: BJ20030582, DOI: 10.1042/BJ20030582, ISSN: 1470-8728.
Fingleton B. CMT-3. CollaGenex. Curr Opin Investig Drugs. 2003 Dec; 4(12): 1460-7. PMID: 14763133, ISSN: 1472-4472.
Fingleton B. Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects. Expert Opin. Ther. Targets. 2003 Jun; 7(3): 385-97. PMID: 12783574, DOI: 10.1517/14728222.7.3.385, ISSN: 1744-7631.
Vargo-Gogola T, Crawford HC, Fingleton B, Matrisian LM. Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand. Arch. Biochem. Biophys. 2002 Dec 12/15/2002; 408(2): 155-61. PMID: 12464266, PII: S0003986102005258, ISSN: 0003-9861.
Vargo-Gogola T, Fingleton B, Crawford HC, Matrisian LM. Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Cancer Res. 2002 Oct 10/1/2002; 62(19): 5559-63. PMID: 12359768, ISSN: 0008-5472.
Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science. 2002 Mar 3/29/2002; 295(5564): 2387-92. PMID: 11923519, PII: 295/5564/2387, DOI: 10.1126/science.1067100, ISSN: 1095-9203.
Fingleton B, Vargo-Gogola T, Crawford HC, Matrisian LM. Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis. Neoplasia. 2001 Nov; 3(6): 459-68. PMID: 11774028, PMCID: PMC1506562, DOI: 10.1038/sj/neo/7900190, ISSN: 1522-8002.
Fingleton B, Matrisian LM. Matrix metalloproteinases as targets for therapy in Kaposi sarcoma. Curr Opin Oncol. 2001 Sep; 13(5): 368-73. PMID: 11555714, ISSN: 1040-8746.
Crawford HC, Fingleton B, Gustavson MD, Kurpios N, Wagenaar RA, Hassell JA, Matrisian LM. The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol. Cell. Biol. 2001 Feb; 21(4): 1370-83. PMID: 11158322, PMCID: PMC99589, DOI: 10.1128/MCB.21.4.1370-1383.2001, ISSN: 0270-7306.
Noë V, Fingleton B, Jacobs K, Crawford HC, Vermeulen S, Steelant W, Bruyneel E, Matrisian LM, Mareel M. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J. Cell. Sci. 2001 Jan; 114(Pt 1): 111-8. PMID: 11112695, ISSN: 0021-9533.
Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol. 2000 Mar; 18(5): 1135-49. PMID: 10694567, ISSN: 0732-183X.
Haro H, Crawford HC, Fingleton B, Shinomiya K, Spengler DM, Matrisian LM. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J. Clin. Invest. 2000 Jan; 105(2): 143-50. PMID: 10642592, PMCID: PMC377426, DOI: 10.1172/JCI7091, ISSN: 0021-9738.
Haro H, Crawford HC, Fingleton B, MacDougall JR, Shinomiya K, Spengler DM, Matrisian LM. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J. Clin. Invest. 2000 Jan; 105(2): 133-41. PMID: 10642591, PMCID: PMC377425, DOI: 10.1172/JCI7090, ISSN: 0021-9738.
Powell WC, Fingleton B, Wilson CL, Boothby M, Matrisian LM. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr. Biol. 1999 Dec 12/16/1999; 9(24): 1441-7. PMID: 10607586, PII: S0960-9822(00)80113-X, ISSN: 0960-9822.
Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, Matrisian LM. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene. 1999 May 5/6/1999; 18(18): 2883-91. PMID: 10362259, DOI: 10.1038/sj.onc.1202627, ISSN: 0950-9232.
Fingleton BM, Heppner Goss KJ, Crawford HC, Matrisian LM. Matrilysin in early stage intestinal tumorigenesis. APMIS. 1999 Jan; 107(1): 102-10. PMID: 10190286, ISSN: 0903-4641.
Fingleton B, McDonnell S. Cytokine regulation of matrilysin gene expression. Biochem. Soc. Trans. 1997 May; 25(2): 155S. PMID: 9191199, ISSN: 0300-5127.
McDonnell S, Fingleton B. Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors. Cytotechnology. 1993; 12(1-3): 367-84. PMID: 7764458, ISSN: 0920-9069.
Bindeman WE, Fingleton B. Glycosylation as a regulator of site-specific metastasis. Cancer Metastasis Rev [print-electronic]. 2022 Mar; 41(1): 107-29. PMID: 34967926, PMCID: PMC8930623, PII: 10.1007/s10555-021-10015-1, DOI: 10.1007/s10555-021-10015-1, ISSN: 1573-7233.
Wolf EM, Fingleton B, Hasty AH. The therapeutic potential of TREM2 in cancer. Front Oncol. 2022; 12: 984193. PMID: 36119485, PMCID: PMC9479103, DOI: 10.3389/fonc.2022.984193, ISSN: 2234-943X.
Williams D, Fingleton B. Measurement of Metabolites from Migrating Cells. Methods Mol Biol. 2021; 2294: 143-50. PMID: 33742399, DOI: 10.1007/978-1-0716-1350-4_10, ISSN: 1940-6029.
Banan B, Beckstead JA, Dunavant LE, Sohn Y, Adcock JM, Nomura S, Abumrad N, Goldenring JR, Fingleton B. Development of a novel murine model of lymphatic metastasis. Clin Exp Metastasis [print-electronic]. 2020 Apr; 37(2): 247-55. PMID: 32052231, PMCID: PMC7979265, PII: 10.1007/s10585-020-10025-3, DOI: 10.1007/s10585-020-10025-3, ISSN: 1573-7276.
Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA, . The importance of developing therapies targeting the biological spectrum of metastatic disease. Clin Exp Metastasis [print-electronic]. 2019 Aug; 36(4): 305-9. PMID: 31102066, PMCID: PMC8794535, PII: 10.1007/s10585-019-09972-3, DOI: 10.1007/s10585-019-09972-3, ISSN: 1573-7276.
Williams D, Fingleton B. Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis. Clin Exp Metastasis [print-electronic]. 2019 Jun; 36(3): 211-24. PMID: 31073762, PMCID: PMC6538276, PII: 10.1007/s10585-019-09967-0, DOI: 10.1007/s10585-019-09967-0, ISSN: 1573-7276.
Thompson JJ, Short SP, Parang B, Brown RE, Li C, Ng VH, Saito-Diaz K, Choksi YA, Washington MK, Smith JJ, Fingleton B, Brand T, Lee E, Coffey RJ, Williams CS. Blood vessel epicardial substance (BVES) reduces LRP6 receptor and cytoplasmic -catenin levels to modulate Wnt signaling and intestinal homeostasis. Carcinogenesis [print-electronic]. 2019 Jan 1/23/2019; 40(9): 1086-98. PMID: 30689807, PMCID: PMC8067673, PII: 5299709, DOI: 10.1093/carcin/bgz007, ISSN: 1460-2180.
Fingleton B, Lange K, Caldwell B, Bankaitis KV, . Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example. Clin Exp Metastasis [print-electronic]. 2017 Dec; 34(8): 443-7. PMID: 29484519, PII: 10.1007/s10585-017-9872-8, DOI: 10.1007/s10585-017-9872-8, ISSN: 1573-7276.
Fingleton B. Making Cancer Quiescent: SPDEF De-Cycles Beta-Catenin [editorial]. Gastroenterology [print-electronic]. 2017 Jul; 153(1): 10-2. PMID: 28572010, PII: S0016-5085(17)35683-4, DOI: 10.1053/j.gastro.2017.05.041, ISSN: 1528-0012.
Fingleton B. Matrix metalloproteinases as regulators of inflammatory processes. Biochim. Biophys. Acta [print-electronic]. 2017 May 5/11/2017; PMID: 28502592, PII: S0167-4889(17)30121-0, DOI: 10.1016/j.bbamcr.2017.05.010, ISSN: 0006-3002.
Bankaitis K, Borriello L, Cox T, Lynch C, Zijlstra A, Fingleton B, Gužvic M, Anderson R, Neman J. Meeting report: Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis. Clin. Exp. Metastasis [print-electronic]. 2017 Apr; 34(3-4): 203-13. PMID: 28260197, PII: 10.1007/s10585-017-9842-1, DOI: 10.1007/s10585-017-9842-1, ISSN: 1573-7276.
Bankaitis KV, Fingleton B. Targeting IL4/IL4R for the treatment of epithelial cancer metastasis. Clin. Exp. Metastasis [print-electronic]. 2015 Dec; 32(8): 847-56. PMID: 26385103, PMCID: PMC4651701, PII: 10.1007/s10585-015-9747-9, DOI: 10.1007/s10585-015-9747-9, ISSN: 1573-7276.
Venmar KT, Kimmel DW, Cliffel DE, Fingleton B. IL4 receptor a mediates enhanced glucose and glutamine metabolism to support breast cancer growth. Biochim. Biophys. Acta [print-electronic]. 2015 May; 1853(5): 1219-28. PMID: 25746764, PMCID: PMC4380623, PII: S0167-4889(15)00070-1, DOI: 10.1016/j.bbamcr.2015.02.020, ISSN: 0006-3002.
Shay G, Lynch CC, Fingleton B. Moving targets: Emerging roles for MMPs in cancer progression and metastasis. Matrix Biol [print-electronic]. 2015 May; 44-46: 200-6. PMID: 25652204, PMCID: PMC4564058, PII: S0945-053X(15)00033-5, DOI: 10.1016/j.matbio.2015.01.019, ISSN: 1569-1802.
Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res [print-electronic]. 2015 Apr 4/15/2015; 75(8): 1624-34. PMID: 25691457, PMCID: PMC4401663, PII: 0008-5472.CAN-14-2379, DOI: 10.1158/0008-5472.CAN-14-2379, ISSN: 1538-7445.
Bates AL, Pickup MW, Hallett MA, Dozier EA, Thomas S, Fingleton B. Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases. J. Pathol [print-electronic]. 2015 Apr; 235(5): 773-83. PMID: 25469981, PMCID: PMC4357558, DOI: 10.1002/path.4493, ISSN: 1096-9896.
Mendonsa AM, VanSaun MN, Ustione A, Piston DW, Fingleton BM, Gorden DL. Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver. Mol. Cancer. 2015; 14: 49. PMID: 25880591, PMCID: PMC4351934, PII: 10.1186/s12943-014-0282-0, DOI: 10.1186/s12943-014-0282-0, ISSN: 1476-4598.
Venmar KT, Fingleton B. Lessons from immunology: IL4R directly promotes mammary tumor metastasis. Oncoimmunology. 2014 Oct; 3(9): e955373. PMID: 25941616, PMCID: PMC4292563, PII: 955373, DOI: 10.4161/21624011.2014.955373, ISSN: 2162-4011.
Venmar KT, Carter KJ, Hwang DG, Dozier EA, Fingleton B. IL4 receptor ILR4a regulates metastatic colonization by mammary tumors through multiple signaling pathways. Cancer Res [print-electronic]. 2014 Aug 8/15/2014; 74(16): 4329-40. PMID: 24947041, PMCID: PMC4134711, PII: 0008-5472.CAN-14-0093, DOI: 10.1158/0008-5472.CAN-14-0093, ISSN: 1538-7445.
Petersen CP, Weis VG, Nam KT, Sousa JF, Fingleton B, Goldenring JR. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology [print-electronic]. 2014 Jun; 146(7): 1727-38.e8. PMID: 24534633, PMCID: PMC4035414, PII: S0016-5085(14)00218-2, DOI: 10.1053/j.gastro.2014.02.007, ISSN: 1528-0012.
Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE. Targeting the Wnt pathway in synovial sarcoma models. Cancer Discov [print-electronic]. 2013 Nov; 3(11): 1286-301. PMID: 23921231, PMCID: PMC3823757, PII: 2159-8290.CD-13-0138, DOI: 10.1158/2159-8290.CD-13-0138, ISSN: 2159-8290.
Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS ONE [electronic-print]. 2013; 8(7): e67845. PMID: 23861820, PMCID: PMC3701622, PII: PONE-D-13-14817, DOI: 10.1371/journal.pone.0067845, ISSN: 1932-6203.
Hallett MA, Venmar KT, Fingleton B. Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13. Cancer Res [print-electronic]. 2012 Dec 12/15/2012; 72(24): 6338-43. PMID: 23222300, PMCID: PMC3531868, PII: 0008-5472.CAN-12-3544, DOI: 10.1158/0008-5472.CAN-12-3544, ISSN: 1538-7445.
Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B. Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Lab. Invest [print-electronic]. 2012 Dec; 92(12): 1749-59. PMID: 23044923, PMCID: PMC3510327, PII: labinvest2012141, DOI: 10.1038/labinvest.2012.141, ISSN: 1530-0307.
Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.
Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS ONE [print-electronic]. 2012; 7(12): e51205. PMID: 23251453, PMCID: PMC3521008, PII: PONE-D-12-22965, DOI: 10.1371/journal.pone.0051205, ISSN: 1932-6203.
Thiolloy S, Edwards JR, Fingleton B, Rifkin DB, Matrisian LM, Lynch CC. An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS ONE [print-electronic]. 2012; 7(1): e29862. PMID: 22238668, PMCID: PMC3251607, PII: PONE-D-11-14696, DOI: 10.1371/journal.pone.0029862, ISSN: 1932-6203.
Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res [print-electronic]. 2011 Feb 2/15/2011; 71(4): 1302-12. PMID: 21303973, PMCID: PMC3150168, PII: 0008-5472.CAN-10-3317, DOI: 10.1158/0008-5472.CAN-10-3317, ISSN: 1538-7445.
Koon HB, Fingleton B, Lee JY, Geyer JT, Cesarman E, Parise RA, Egorin MJ, Dezube BJ, Aboulafia D, Krown SE. Phase II AIDS Malignancy Consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma. J. Acquir. Immune Defic. Syndr. 2011 Jan 1/1/2011; 56(1): 64-8. PMID: 21068672, PMCID: PMC3017346, DOI: 10.1097/QAI.0b013e3181fc0141, ISSN: 1944-7884.
Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1273-81. PMID: 20595227, PMCID: PMC3001265, PII: 201001-0001OC, DOI: 10.1164/rccm.201001-0001OC, ISSN: 1535-4970.
Koller FL, Hwang DG, Dozier EA, Fingleton B. Epithelial interleukin-4 receptor expression promotes colon tumor growth. Carcinogenesis [print-electronic]. 2010 Jun; 31(6): 1010-7. PMID: 20176658, PMCID: PMC2878360, PII: bgq044, DOI: 10.1093/carcin/bgq044, ISSN: 1460-2180.
Fingleton B. Inflammatory proteinase slips into tumor cells. Nature medicine. 2010 Feb; 16(2) Sect. 161,3.
Fingleton B, Lynch CC. A new dress code for MMPs: cleavage optional. Dev. Cell. 2010 Jan 1/19/2010; 18(1): 3-4. PMID: 20152171, PII: S1534-5807(10)00004-3, DOI: 10.1016/j.devcel.2010.01.003, ISSN: 1878-1551.
Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res. 2010 Jan 1/1/2010; 70(1): 30-5. PMID: 20048070, PMCID: PMC2804939, PII: 0008-5472.CAN-09-2899, DOI: 10.1158/0008-5472.CAN-09-2899, ISSN: 1538-7445.
Lynch CC, Vargo-Gogola T, Matrisian LM, Fingleton B. Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA. J Oncol [print-electronic]. 2010; 2010: 530745. PMID: 20628524, PMCID: PMC2902104, DOI: 10.1155/2010/530745, ISSN: 1687-8469.
Sinnamon MJ, Carter KJ, Fingleton B, Matrisian LM. Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse. Int J Exp Pathol. 2008 Dec; 89(6): 466-75. PMID: 19134056, PMCID: PMC2669608, PII: IEP621, DOI: 10.1111/j.1365-2613.2008.00621.x, ISSN: 1365-2613.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM. P120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol. Biol. Cell [print-electronic]. 2008 Oct; 19(10): 4110-21. PMID: 18653469, PMCID: PMC2555941, PII: E08-03-0283, DOI: 10.1091/mbc.E08-03-0283, ISSN: 1939-4586.
Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JO. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med. 2008 Sep; 60(3): 718-26. PMID: 18727087, PMCID: PMC2646120, DOI: 10.1002/mrm.21724, ISSN: 1522-2594.
Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, Fingleton B. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res. 2008 Aug 8/1/2008; 68(15): 6251-9. PMID: 18676849, PMCID: PMC2789265, PII: 68/15/6251, DOI: 10.1158/0008-5472.CAN-08-0537, ISSN: 1538-7445.
Sinnamon MJ, Carter KJ, Sims LP, Lafleur B, Fingleton B, Matrisian LM. A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis [print-electronic]. 2008 Apr; 29(4): 880-6. PMID: 18258601, PII: bgn040, DOI: 10.1093/carcin/bgn040, ISSN: 1460-2180.
Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Yull FE, Blackwell TS, Fingleton B. Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol. Cancer Res. 2008 Mar; 6(3): 364-71. PMID: 18337446, PII: 6/3/364, DOI: 10.1158/1541-7786.MCR-07-0309, ISSN: 1541-7786.
Fingleton B. MMPs as therapeutic targets--still a viable option?. Semin. Cell Dev. Biol [print-electronic]. 2008 Feb; 19(1): 61-8. PMID: 17693104, PMCID: PMC2677300, PII: S1084-9521(07)00091-2, DOI: 10.1016/j.semcdb.2007.06.006, ISSN: 1084-9521.
Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Polosukhin VV, Fingleton B, Yull FE, Blackwell TS. Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clin. Exp. Metastasis [print-electronic]. 2008; 25(1): 43-51. PMID: 18008176, DOI: 10.1007/s10585-007-9100-z, ISSN: 0262-0898.
Martin MD, Fingleton B, Lynch CC, Wells S, McIntyre JO, Piston DW, Matrisian LM. Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin. Exp. Metastasis [print-electronic]. 2008; 25(8): 877-85. PMID: 18787962, PMCID: PMC2588650, DOI: 10.1007/s10585-008-9206-y, ISSN: 1573-7276.
Stathopoulos GT, Sherrill TP, Cheng DS, Scoggins RM, Han W, Polosukhin VV, Connelly L, Yull FE, Fingleton B, Blackwell TS. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Nov 11/20/2007; 104(47): 18514-9. PMID: 18000061, PMCID: PMC2141808, PII: 0705316104, DOI: 10.1073/pnas.0705316104, ISSN: 1091-6490.
Lepage M, Dow WC, Melchior M, You Y, Fingleton B, Quarles CC, Pépin C, Gore JC, Matrisian LM, McIntyre JO. Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch. Mol Imaging. 2007 Nov; 6(6): 393-403. PMID: 18053410, ISSN: 1535-3508.
Gorden DL, Fingleton B, Crawford HC, Jansen DE, Lepage M, Matrisian LM. Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int. J. Cancer. 2007 Aug 8/1/2007; 121(3): 495-500. PMID: 17417772, DOI: 10.1002/ijc.22594, ISSN: 0020-7136.
Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res. 2007 Jul 7/15/2007; 67(14): 6760-7. PMID: 17638887, PII: 67/14/6760, DOI: 10.1158/0008-5472.CAN-07-0026, ISSN: 0008-5472.
Fingleton B, Carter KJ, Matrisian LM. Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res. 2007 May 5/15/2007; 67(10): 4800-6. PMID: 17510409, PII: 67/10/4800, DOI: 10.1158/0008-5472.CAN-06-4473, ISSN: 0008-5472.
Fingleton B. Molecular targets in metastasis: lessons from genomic approaches. Cancer Genomics Proteomics. 2007 May; 4(3): 211-21. PMID: 17878524, ISSN: 1109-6535.
Schwartz DR, Moin K, Yao B, Matrisian LM, Coussens LM, Bugge TH, Fingleton B, Acuff HB, Sinnamon M, Nassar H, Platts AE, Krawetz SA, Linebaugh BE, Sloane BF. Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol. Cancer Res. 2007 May; 5(5): 443-54. PMID: 17510311, PII: 5/5/443, DOI: 10.1158/1541-7786.MCR-06-0337, ISSN: 1541-7786.
Fingleton B, Powell WC, Crawford HC, Couchman JR, Matrisian LM. A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt). 2007 Feb; 26(1): 22-7. PMID: 17316082, PMCID: PMC3838102, DOI: 10.1089/hyb.2006.028, ISSN: 1554-0014.
Fingleton B. Matrix metalloproteinases as valid clinical targets. Curr. Pharm. Des. 2007; 13(3): 333-46. PMID: 17313364, ISSN: 1873-4286.
Acuff HB, Sinnamon M, Fingleton B, Boone B, Levy SE, Chen X, Pozzi A, Carbone DP, Schwartz DR, Moin K, Sloane BF, Matrisian LM. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res. 2006 Aug 8/15/2006; 66(16): 7968-75. PMID: 16912171, PII: 66/16/7968, DOI: 10.1158/0008-5472.CAN-05-4279, ISSN: 1538-7445.
Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM. Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res. 2006 Jan 1/1/2006; 66(1): 259-66. PMID: 16397239, PMCID: PMC1360653, PII: 66/1/259, DOI: 10.1158/0008-5472.CAN-05-2502, ISSN: 0008-5472.
Fingleton B. Matrix metalloproteinases: roles in cancer and metastasis. Front. Biosci. 2006; 11: 479-91. PMID: 16146745, PII: 1811, ISSN: 1093-9946.
Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int. J. Cancer. 2005 Aug 8/10/2005; 116(1): 52-61. PMID: 15756690, DOI: 10.1002/ijc.20997, ISSN: 0020-7136.
Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell. 2005 May; 7(5): 485-96. PMID: 15894268, PII: S1535-6108(05)00124-8, DOI: 10.1016/j.ccr.2005.04.013, ISSN: 1535-6108.
Harrell PC, McCawley LJ, Fingleton B, McIntyre JO, Matrisian LM. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp. Cell Res [print-electronic]. 2005 Feb 2/15/2005; 303(2): 308-20. PMID: 15652345, PII: S0014-4827(04)00574-9, DOI: 10.1016/j.yexcr.2004.09.020, ISSN: 0014-4827.
Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin. Exp. Metastasis. 2005; 22(2): 185-93. PMID: 16086239, DOI: 10.1007/s10585-005-7453-8, ISSN: 0262-0898.
Fingleton B, Menon R, Carter KJ, Overstreet PD, Hachey DL, Matrisian LM, McIntyre JO. Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Clin. Cancer Res. 2004 Dec 12/1/2004; 10(23): 7865-74. PMID: 15585619, PII: 10/23/7865, DOI: 10.1158/1078-0432.CCR-04-1252, ISSN: 1078-0432.
Gustavson MD, Crawford HC, Fingleton B, Matrisian LM. Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters. Mol. Carcinog. 2004 Nov; 41(3): 125-39. PMID: 15457508, DOI: 10.1002/mc.20049, ISSN: 0899-1987.
Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 2004 Oct; 6(4): 409-21. PMID: 15488763, PII: S1535610804002703, DOI: 10.1016/j.ccr.2004.08.031, ISSN: 1535-6108.
Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat. Genet [print-electronic]. 2004 Sep; 36(9): 969-77. PMID: 15322543, PII: ng1413, DOI: 10.1038/ng1413, ISSN: 1061-4036.
Hulboy DL, Gautam S, Fingleton B, Matrisian LM. The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol. Rep. 2004 Jul; 12(1): 13-7. PMID: 15201952, ISSN: 1021-335X.
McIntyre JO, Fingleton B, Wells KS, Piston DW, Lynch CC, Gautam S, Matrisian LM. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem. J. 2004 Feb 2/1/2004; 377(Pt 3): 617-28. PMID: 14556651, PMCID: PMC1223892, PII: BJ20030582, DOI: 10.1042/BJ20030582, ISSN: 1470-8728.
Fingleton B. CMT-3. CollaGenex. Curr Opin Investig Drugs. 2003 Dec; 4(12): 1460-7. PMID: 14763133, ISSN: 1472-4472.
Fingleton B. Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects. Expert Opin. Ther. Targets. 2003 Jun; 7(3): 385-97. PMID: 12783574, DOI: 10.1517/14728222.7.3.385, ISSN: 1744-7631.
Vargo-Gogola T, Crawford HC, Fingleton B, Matrisian LM. Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand. Arch. Biochem. Biophys. 2002 Dec 12/15/2002; 408(2): 155-61. PMID: 12464266, PII: S0003986102005258, ISSN: 0003-9861.
Vargo-Gogola T, Fingleton B, Crawford HC, Matrisian LM. Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Cancer Res. 2002 Oct 10/1/2002; 62(19): 5559-63. PMID: 12359768, ISSN: 0008-5472.
Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science. 2002 Mar 3/29/2002; 295(5564): 2387-92. PMID: 11923519, PII: 295/5564/2387, DOI: 10.1126/science.1067100, ISSN: 1095-9203.
Fingleton B, Vargo-Gogola T, Crawford HC, Matrisian LM. Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis. Neoplasia. 2001 Nov; 3(6): 459-68. PMID: 11774028, PMCID: PMC1506562, DOI: 10.1038/sj/neo/7900190, ISSN: 1522-8002.
Fingleton B, Matrisian LM. Matrix metalloproteinases as targets for therapy in Kaposi sarcoma. Curr Opin Oncol. 2001 Sep; 13(5): 368-73. PMID: 11555714, ISSN: 1040-8746.
Crawford HC, Fingleton B, Gustavson MD, Kurpios N, Wagenaar RA, Hassell JA, Matrisian LM. The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol. Cell. Biol. 2001 Feb; 21(4): 1370-83. PMID: 11158322, PMCID: PMC99589, DOI: 10.1128/MCB.21.4.1370-1383.2001, ISSN: 0270-7306.
Noë V, Fingleton B, Jacobs K, Crawford HC, Vermeulen S, Steelant W, Bruyneel E, Matrisian LM, Mareel M. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J. Cell. Sci. 2001 Jan; 114(Pt 1): 111-8. PMID: 11112695, ISSN: 0021-9533.
Nelson AR, Fingleton B, Rothenberg ML, Matrisian LM. Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol. 2000 Mar; 18(5): 1135-49. PMID: 10694567, ISSN: 0732-183X.
Haro H, Crawford HC, Fingleton B, Shinomiya K, Spengler DM, Matrisian LM. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J. Clin. Invest. 2000 Jan; 105(2): 143-50. PMID: 10642592, PMCID: PMC377426, DOI: 10.1172/JCI7091, ISSN: 0021-9738.
Haro H, Crawford HC, Fingleton B, MacDougall JR, Shinomiya K, Spengler DM, Matrisian LM. Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption. J. Clin. Invest. 2000 Jan; 105(2): 133-41. PMID: 10642591, PMCID: PMC377425, DOI: 10.1172/JCI7090, ISSN: 0021-9738.
Powell WC, Fingleton B, Wilson CL, Boothby M, Matrisian LM. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr. Biol. 1999 Dec 12/16/1999; 9(24): 1441-7. PMID: 10607586, PII: S0960-9822(00)80113-X, ISSN: 0960-9822.
Crawford HC, Fingleton BM, Rudolph-Owen LA, Goss KJ, Rubinfeld B, Polakis P, Matrisian LM. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene. 1999 May 5/6/1999; 18(18): 2883-91. PMID: 10362259, DOI: 10.1038/sj.onc.1202627, ISSN: 0950-9232.
Fingleton BM, Heppner Goss KJ, Crawford HC, Matrisian LM. Matrilysin in early stage intestinal tumorigenesis. APMIS. 1999 Jan; 107(1): 102-10. PMID: 10190286, ISSN: 0903-4641.
Fingleton B, McDonnell S. Cytokine regulation of matrilysin gene expression. Biochem. Soc. Trans. 1997 May; 25(2): 155S. PMID: 9191199, ISSN: 0300-5127.
McDonnell S, Fingleton B. Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors. Cytotechnology. 1993; 12(1-3): 367-84. PMID: 7764458, ISSN: 0920-9069.