Peter Hedera, M.D.

Associate Professor

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Faculty Appointments
Associate Professor of Neurology
M.D., Medicine, Univerzita Komenského, Bratislava, Slovakia
Office Address
465 21st Avenue, South, 6140 MRB III
6140 MRB III
Nashville, TN 37232-8552
Research Description
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Research Keywords
Hereditary Spastic Paraplegia/Epilepsy
Hedera P, Blair MA, Andermann E, Andermann F, D'Agostino D, Taylor KA, Chahine L, Pandolfo M, Bradford Y, Haines JL, Abou-Khalil B. Familial mesial temporal lobe epilepsy maps to chromosome 4q13.2-q21.3. Neurology [print-electronic]. 2007 Jun 6/12/2007; 68(24): 2107-12. PMID: 17377072, PII: 01.wnl.0000261246.75977.89, DOI: 10.1212/01.wnl.0000261246.75977.89, ISSN: 1526-632X.

Blair MA, Ma S, Abou-Khalil B, Hedera P. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. Eur. J. Neurol. 2007 Apr; 14(4): 424-7. PMID: 17388992, PII: ENE1702, DOI: 10.1111/j.1468-1331.2007.01702.x, ISSN: 1468-1331.

Abou-Khalil B, Krei L, Lazenby B, Harris PA, Haines JL, Hedera P. Familial genetic predisposition, epilepsy localization and antecedent febrile seizures. Epilepsy Res [print-electronic]. 2007 Jan; 73(1): 104-10. PMID: 17046202, PII: S0920-1211(06)00354-8, DOI: 10.1016/j.eplepsyres.2006.08.005, ISSN: 0920-1211.

Hedera P, Ma S, Blair MA, Taylor KA, Hamati A, Bradford Y, Abou-Khalil B, Haines JL. Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22. Epilepsia. 2006 Oct; 47(10): 1622-8. PMID: 17054683, PII: EPI637, DOI: 10.1111/j.1528-1167.2006.00637.x, ISSN: 0013-9580.

Ma S, Blair MA, Abou-Khalil B, Lagrange AH, Gurnett CA, Hedera P. Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. Epilepsy Res [print-electronic]. 2006 Oct; 71(2-3): 129-34. PMID: 16839746, PII: S0920-1211(06)00214-2, DOI: 10.1016/j.eplepsyres.2006.06.001, ISSN: 0920-1211.

Ma S, Davis TL, Blair MA, Fang JY, Bradford Y, Haines JL, Hedera P. Familial essential tremor with apparent autosomal dominant inheritance: should we also consider other inheritance modes?. Mov. Disord. 2006 Sep; 21(9): 1368-74. PMID: 16721753, DOI: 10.1002/mds.20950, ISSN: 0885-3185.

Blair MA, Ma S, Hedera P. Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia. Neurogenetics [print-electronic]. 2006 Mar; 7(1): 47-50. PMID: 16489470, DOI: 10.1007/s10048-005-0027-8, ISSN: 1364-6745.

Ma S, Abou-Khalil B, Blair MA, Sutcliffe JS, Haines JL, Hedera P. Mutations in GABRA1, GABRA5, GABRG2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures. Neurosci. Lett [print-electronic]. 2006 Feb 2/6/2006; 394(1): 74-8. PMID: 16256272, PII: S0304-3940(05)01156-0, DOI: 10.1016/j.neulet.2005.10.006, ISSN: 0304-3940.

Ma S, Abou-Khalil B, Sutcliffe JS, Haines JL, Hedera P. The GABBR1 locus and the G1465A variant is not associated with temporal lobe epilepsy preceded by febrile seizures. BMC Med. Genet. 2005 Mar 3/30/2005; 6: 13. PMID: 15799783, PMCID: PMC1079842, PII: 1471-2350-6-13, DOI: 10.1186/1471-2350-6-13, ISSN: 1471-2350.

Hedera P, Fenichel GM, Blair M, Haines JL. Novel mutation in the SPG3A gene in an African American family with an early onset of hereditary spastic paraplegia. Arch. Neurol. 2004 Oct; 61(10): 1600-3. PMID: 15477516, PII: 61/10/1600, DOI: 10.1001/archneur.61.10.1600, ISSN: 0003-9942.

Hedera P, Abou-Khalil B, Crunk AE, Taylor KA, Haines JL, Sutcliffe JS. Autosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 gene. Epilepsia. 2004 Mar; 45(3): 218-22. PMID: 15009222, ISSN: 0013-9580.

Hedera P, Gorski JL. Oculo-facio-cardio-dental syndrome: skewed X chromosome inactivation in mother and daughter suggest X-linked dominant Inheritance. Am. J. Med. Genet. A. 2003 Dec 12/15/2003; 123A(3): 261-6. PMID: 14608648, DOI: 10.1002/ajmg.a.20444, ISSN: 1552-4825.

Hedera P, Innis JW. Juberg-Hayward syndrome: report of a new patient with severe phenotype and novel clinical features. Am. J. Med. Genet. A. 2003 Oct 10/15/2003; 122A(3): 257-60. PMID: 12966528, DOI: 10.1002/ajmg.a.20263, ISSN: 1552-4825.

Hedera P, Petty EM, Bui MR, Blaivas M, Fink JK. The second kindred with autosomal dominant distal myopathy linked to chromosome 14q: genetic and clinical analysis. Arch. Neurol. 2003 Sep; 60(9): 1321-5. PMID: 12975303, PII: 60/9/1321, DOI: 10.1001/archneur.60.9.1321, ISSN: 0003-9942.

Hedera P, Fink JK, Bockenstedt PL, Brewer GJ. Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome. Arch. Neurol. 2003 Sep; 60(9): 1303-6. PMID: 12975299, PII: 60/9/1303, DOI: 10.1001/archneur.60.9.1303, ISSN: 0003-9942.

Brewer GJ, Hedera P, Kluin KJ, Carlson M, Askari F, Dick RB, Sitterly J, Fink JK. Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy. Arch. Neurol. 2003 Mar; 60(3): 379-85. PMID: 12633149, PII: noc20248, ISSN: 0003-9942.

Hedera P, Turner RS. Inherited dementias. Neurol Clin. 2002 Aug; 20(3): 779-808, vii. PMID: 12432830, ISSN: 0733-8619.

Hedera P, Innis JW. Possible third case of Lin-Gettig syndrome. Am. J. Med. Genet. 2002 Jul 7/15/2002; 110(4): 380-3. PMID: 12116213, DOI: 10.1002/ajmg.10460, ISSN: 0148-7299.

Hedera P, Toriello HV, Petty EM. Novel autosomal dominant mandibulofacial dysostosis with ptosis: clinical description and exclusion of TCOF1. J. Med. Genet. 2002 Jul; 39(7): 484-8. PMID: 12114479, PMCID: PMC1735177, ISSN: 1468-6244.

Hedera P, Brewer GJ, Fink JK. White matter changes in Wilson disease. Arch. Neurol. 2002 May; 59(5): 866-7. PMID: 12020274, PII: nim10018, ISSN: 0003-9942.

Hedera P, Rainier S, Zhao XP, Schalling M, Lindblad K, Yuan QP, Ikeuchi T, Trobe J, Wald JJ, Eldevik OP, Kluin K, Fink JK. Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder. Neurology. 2002 Feb 2/12/2002; 58(3): 411-6. PMID: 11839840, ISSN: 0028-3878.

Hedera P, Alvarado D, Beydoun A, Fink JK. Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4. Ann. Neurol. 2002 Jan; 51(1): 45-50. PMID: 11782983, PII: 10.1002/ana.10051, ISSN: 0364-5134.

Rainier S, Hedera P, Alvarado D, Zhao X, Kleopa KA, Heiman-Patterson T, Fink JK. Hereditary spastic paraplegia linked to chromosome 14q11-q21: reduction of the SPG3 locus interval from 5.3 to 2.7 cM [letter]. J. Med. Genet. 2001 Nov; 38(11): E39. PMID: 11694553, PMCID: PMC1734767, ISSN: 1468-6244.

Zhao X, Alvarado D, Rainier S, Lemons R, Hedera P, Weber CH, Tukel T, Apak M, Heiman-Patterson T, Ming L, Bui M, Fink JK. Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia. Nat. Genet. 2001 Nov; 29(3): 326-31. PMID: 11685207, PII: ng758, DOI: 10.1038/ng758, ISSN: 1061-4036.

Hedera P, Gorski JL. Retinitis pigmentosa, growth hormone deficiency, and acromelic skeletal dysplasia in two brothers: possible familial RHYNS syndrome. Am. J. Med. Genet. 2001 Jun 6/15/2001; 101(2): 142-5. PMID: 11391657, PII: 10.1002/ajmg.1338, ISSN: 0148-7299.

Hedera P, Williamson JA, Rainier S, Alvarado D, Tukel T, Apak M, Fink JK. Prenatal diagnosis of hereditary spastic paraplegia. Prenat. Diagn. 2001 Mar; 21(3): 202-6. PMID: 11260609, PII: 10.1002/1097-0223(200103)21:3<202::AID-PD4>3.0.CO;2-U, ISSN: 0197-3851.

Hedera P. Ethical principles and pitfalls of genetic testing for dementia. J Geriatr Psychiatry Neurol. 2001; 14(4): 213-21. PMID: 11794449, ISSN: 0891-9887.

Hedera P, DiMauro S, Bonilla E, Wald JJ, Fink JK. Mitochondrial analysis in autosomal dominant hereditary spastic paraplegia. Neurology. 2000 Nov 11/28/2000; 55(10): 1591-2. PMID: 11094129, ISSN: 0028-3878.

Brewer GJ, Johnson VD, Dick RD, Hedera P, Fink JK, Kluin KJ. Treatment of Wilson's disease with zinc. XVII: treatment during pregnancy. Hepatology. 2000 Feb; 31(2): 364-70. PMID: 10655259, PII: S0270913900619444, DOI: 10.1002/hep.510310216, ISSN: 0270-9139.

Hedera P, DiMauro S, Bonilla E, Wald J, Eldevik OP, Fink JK. Phenotypic analysis of autosomal dominant hereditary spastic paraplegia linked to chromosome 8q. Neurology. 1999 Jul 7/13/1999; 53(1): 44-50. PMID: 10408535, ISSN: 0028-3878.

Hedera P, Rainier S, Alvarado D, Zhao X, Williamson J, Otterud B, Leppert M, Fink JK. Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q. Am. J. Hum. Genet. 1999 Feb; 64(2): 563-9. PMID: 9973294, PMCID: PMC1377766, PII: S0002-9297(07)61762-5, DOI: 10.1086/302258, ISSN: 0002-9297.

Fink JK, Hedera P. Hereditary spastic paraplegia: genetic heterogeneity and genotype-phenotype correlation. Semin Neurol. 1999; 19(3): 301-9. PMID: 12194386, DOI: 10.1055/s-2008-1040846, ISSN: 0271-8235.

Brewer GJ, Fink JK, Hedera P. Diagnosis and treatment of Wilson's disease. Semin Neurol. 1999; 19(3): 261-70. PMID: 12194382, DOI: 10.1055/s-2008-1040842, ISSN: 0271-8235.

Hedera P, Stanton M, Flöer B, Wald JJ. Prolonged coma after continuous sedation with propofol. Eur. Neurol. 1999; 41(2): 116-7. PMID: 10023119, PII: 8017, DOI: 8017, ISSN: 0014-3022.

Hedera P, Bujdáková J, Traubner P, Pancák J. Stroke risk factors and development of collateral flow in carotid occlusive disease. Acta Neurol. Scand. 1998 Sep; 98(3): 182-6. PMID: 9786615, ISSN: 0001-6314.

Hedera P, Wu D, Collins S, Lewin JS, Miller D, Lerner AJ, Klein S, Friedland RP. Sex and electroencephalographic synchronization after photic stimulation predict signal changes in the visual cortex on functional MR images. AJNR Am J Neuroradiol. 1998 May; 19(5): 853-7. PMID: 9613499, ISSN: 0195-6108.

Cohen DL, Hedera P, Premkumar DR, Friedland RP, Kalaria RN. Amyloid-beta protein angiopathies masquerading as Alzheimer's disease?. Ann. N. Y. Acad. Sci. 1997 Sep 9/26/1997; 826: 390-5. PMID: 9329710, ISSN: 0077-8923.

Friedland RP, Kalaria R, Berridge M, Miraldi F, Hedera P, Reno J, Lyle L, Marotta CA. Neuroimaging of vessel amyloid in Alzheimer's disease. Ann. N. Y. Acad. Sci. 1997 Sep 9/26/1997; 826: 242-7. PMID: 9329695, ISSN: 0077-8923.

Fink JK, Hedera P, Mathay JG, Albin RL. Paroxysmal dystonic choreoathetosis linked to chromosome 2q: clinical analysis and proposed pathophysiology. Neurology. 1997 Jul; 49(1): 177-83. PMID: 9222187, ISSN: 0028-3878.

Lerner AJ, Hedera P, Koss E, Stuckey J, Friedland RP. Delirium in Alzheimer disease. Alzheimer Dis Assoc Disord. 1997 Mar; 11(1): 16-20. PMID: 9071440, ISSN: 0893-0341.

Hedera P, Friedland RP. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: study of two American families with predominant dementia. J. Neurol. Sci. 1997 Feb 2/27/1997; 146(1): 27-33. PMID: 9077492, PII: S0022510X96002729, ISSN: 0022-510X.

Hedera P, Lai S, Lewin JS, Haacke EM, Wu D, Lerner AJ, Friedland RP. Assessment of cerebral blood flow reserve using functional magnetic resonance imaging. J Magn Reson Imaging. 1996 Sep; 6(5): 718-25. PMID: 8890009, ISSN: 1053-1807.

Lewin JS, Friedman L, Wu D, Miller DA, Thompson LA, Klein SK, Wise AL, Hedera P, Buckley P, Meltzer H, Friedland RP, Duerk JL. Cortical localization of human sustained attention: detection with functional MR using a visual vigilance paradigm. J Comput Assist Tomogr. 1996 Sep; 20(5): 695-701. PMID: 8797896, ISSN: 0363-8715.

Fink JK, Rainer S, Wilkowski J, Jones SM, Kume A, Hedera P, Albin R, Mathay J, Girbach L, Varvil T, Otterud B, Leppert M. Paroxysmal dystonic choreoathetosis: tight linkage to chromosome 2q. Am. J. Hum. Genet. 1996 Jul; 59(1): 140-5. PMID: 8659518, PMCID: PMC1915128, ISSN: 0002-9297.

Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am. J. Pathol. 1996 Jun; 148(6): 2083-95. PMID: 8669492, PMCID: PMC1861657, ISSN: 0002-9440.

Kalaria RN, Hedera P. Beta-Amyloid vasoactivity in Alzheimer's disease [letter]. Lancet. 1996 May 5/25/1996; 347(9013): 1492-3. PMID: 8676667, ISSN: 0140-6736.

Hedera P. Influence of extreme head rotations on brainstem auditory evoked potentials (BAEP). Clin Neurol Neurosurg. 1995 Nov; 97(4): 290-5. PMID: 8599894, PII: 030384679500058R, ISSN: 0303-8467.

Hedera P, Wu D, Lewin JS, Miller D, Lerner AJ, Friedland RP. Temporal patterns of uncoupling between oxidative metabolism and regional cerebral blood flow demonstrated by functional magnetic resonance imaging. Invest Radiol. 1995 Nov; 30(11): 625-33. PMID: 8557502, ISSN: 0020-9996.

Kalaria RN, Hedera P. Differential degeneration of the cerebral microvasculature in Alzheimer's disease. Neuroreport. 1995 Feb 2/15/1995; 6(3): 477-80. PMID: 7766847, ISSN: 0959-4965.

Hedera P, Lerner AJ, Castellani R, Friedland RP. Concurrence of Alzheimer's disease, Parkinson's disease, diffuse Lewy body disease, and amyotrophic lateral sclerosis. J. Neurol. Sci. 1995 Feb; 128(2): 219-24. PMID: 7738598, PII: 0022510X9400222A, ISSN: 0022-510X.

Hedera P, Bujdáková J, Traubner P. Effect of collateral flow patterns on outcome of carotid occlusion. Eur. Neurol. 1995; 35(4): 212-6. PMID: 7671981, ISSN: 0014-3022.

Hedera P, Bujdáková J, Traubner P. Compressions of carotid and vertebral arteries in assessment of intracranial collateral flow: correlation between angiography and transcranial Doppler ultrasonography. Angiology. 1994 Dec; 45(12): 1039-45. PMID: 7985831, ISSN: 0003-3197.

Hedera P, Lai S, Haacke EM, Lerner AJ, Hopkins AL, Lewin JS, Friedland RP. Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility-sensitized MRI. Neurology. 1994 Oct; 44(10): 1921-6. PMID: 7936248, ISSN: 0028-3878.

Lerner AJ, Koss E, Patterson MB, Ownby RL, Hedera P, Friedland RP, Whitehouse PJ. Concomitants of visual hallucinations in Alzheimer's disease. Neurology. 1994 Mar; 44(3 Pt 1): 523-7. PMID: 8145925, ISSN: 0028-3878.

Haacke EM, Hopkins A, Lai S, Buckley P, Friedman L, Meltzer H, Hedera P, Friedland R, Klein S, Thompson L. 2D and 3D high resolution gradient echo functional imaging of the brain: venous contributions to signal in motor cortex studies. NMR Biomed. 1994 Mar; 7(1-2): 54-62. PMID: 8068526, ISSN: 0952-3480.

Hedera P, Friedland RP. Duane's syndrome with giant aneurysm of the vertebral basilar arterial junction. J Clin Neuroophthalmol. 1993 Dec; 13(4): 271-4. PMID: 8113440, ISSN: 0272-846X.

Lai S, Hopkins AL, Haacke EM, Li D, Wasserman BA, Buckley P, Friedman L, Meltzer H, Hedera P, Friedland R. Identification of vascular structures as a major source of signal contrast in high resolution 2D and 3D functional activation imaging of the motor cortex at 1.5T: preliminary results. Magn Reson Med. 1993 Sep; 30(3): 387-92. PMID: 8412613, ISSN: 0740-3194.

Hedera P, Bujdáková J, Traubner P. Blood flow velocities in basilar artery during rotation of the head. Acta Neurol. Scand. 1993 Sep; 88(3): 229-33. PMID: 7903016, ISSN: 0001-6314.

Friedland RP, Koss E, Lerner A, Hedera P, Ellis W, Dronkers N, Ober BA, Jagust WJ. Functional imaging, the frontal lobes, and dementia. Dementia. 1993 May; 4(3-4): 192-203. PMID: 8401792, ISSN: 1013-7424.

Friedland RP, Lerner AJ, Hedera P, Brass EP. Encephalopathy associated with bismuth subgallate therapy. Clin Neuropharmacol. 1993 Apr; 16(2): 173-6. PMID: 8477413, ISSN: 0362-5664.

Hedera P, Traubner P, Bujdáková J. Short-term prognosis of stroke due to occlusion of internal carotid artery based on transcranial Doppler ultrasonography. Stroke. 1992 Aug; 23(8): 1069-72. PMID: 1636179, ISSN: 0039-2499.