Wonder Puryear Drake, M.D.

Professor

wonder.drake@vanderbilt.edu
Faculty Appointments
Professor of Medicine Professor of Pathology, Microbiology and Immunology
Education
M.D., Medicine , Vanderbilt University, Nashville, TennesseeB.S., University of Alabama, Tuscaloosa, Alabama
Office Address
A-2206 MCN
1161 21st Avenue South
Nashville, TN 37232-2582
Research Description
I am interested in exploring the etiology as well as pathogenesis of chronic inflammatory states, particularly sarcoidosis. I am currently using polymerase chain reactions to investigate possible infectious etiologies of sarcoidosis. We are also using techniques such as in situ hybridization to directly localize microbial nucleic acid in the tissue specimens and molecular microarrays in collaboration with our colleagues at Cleveland Clinic, and Medical University of South Carolina.
Research Keywords
The molecular biolody and immunopathogenesis of chronic inflammatory states, particularly sarcoidosis.
Publications
Chioma OS, Drake WP. Role of Microbial Agents in Pulmonary Fibrosis¿. Yale J Biol Med. 2017 Jun; 90(2): 219-27. PMID: 28656009, PMCID: PMC5482299, ISSN: 1551-4056.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP. Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis. Laryngoscope [print-electronic]. 2016 Nov; 126(11): E356-E361. PMID: 27296163, PMCID: PMC5077677, DOI: 10.1002/lary.26098, ISSN: 0023-852X.

Celada LJ, Rotsinger JE, Young A, Shaginurova G, Shelton D, Hawkins C, Drake WP. Programmed Death-1 Inhibition of PI3K/AKT/mTOR Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2016 Aug 8/26/2016; PMID: 27564547, DOI: 10.1165/rcmb.2016-0037OC, ISSN: 1535-4989.

Rotsinger JE, Celada LJ, Polosukhin VV, Atkinson JB, Drake WP. Molecular Analysis of Sarcoidosis Granulomas Reveals Antimicrobial Targets. Am. J. Respir. Cell Mol. Biol. 2016 Jul; 55(1): 128-34. PMID: 26807608, PMCID: PMC4942207, DOI: 10.1165/rcmb.2015-0212OC, ISSN: 1535-4989.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP. Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species. Laryngoscope [print-electronic]. 2016 Jun 6/14/2016; PMID: 27295947, DOI: 10.1002/lary.26097, ISSN: 1531-4995.

Celada LJ, Hawkins C, Drake WP. The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis. Clin. Chest Med [print-electronic]. 2015 Dec; 36(4): 561-8. PMID: 26593133, PMCID: PMC4660257, PII: S0272-5231(15)00101-X, DOI: 10.1016/j.ccm.2015.08.001, ISSN: 1557-8216.

Kaminski N, Drake WP. Solving the Conundrum: Immunogenetics of Sarcoidosis. Am. J. Respir. Crit. Care Med. 2015 Sep 9/15/2015; 192(6): 652-4. PMID: 26371809, PMCID: PMC4595685, DOI: 10.1164/rccm.201506-1235ED, ISSN: 1535-4970.

Levin AM, Adrianto I, Datta I, Iannuzzi MC, Trudeau S, Li J, Drake WP, Montgomery CG, Rybicki BA. Association of HLA-DRB1 with Sarcoidosis Susceptibility and Progression in African Americans. Am. J. Respir. Cell Mol. Biol. 2015 Aug; 53(2): 206-16. PMID: 25506722, PMCID: PMC4566045, DOI: 10.1165/rcmb.2014-0227OC, ISSN: 1535-4989.

May AK, Brady JS, Romano-Keeler J, Drake WP, Norris PR, Jenkins JM, Isaacs RJ, Boczko EM. A pilot study of the noninvasive assessment of the lung microbiota as a potential tool for the early diagnosis of ventilator-associated pneumonia. Chest. 2015 Jun; 147(6): 1494-502. PMID: 25474571, PMCID: PMC4451706, PII: S0012-3692(15)37204-4, DOI: 10.1378/chest.14-1687, ISSN: 1931-3543.

Celada LJ, Drake WP. Targeting CD4(+) T cells for the treatment of sarcoidosis: a promising strategy?. Immunotherapy. 2015; 7(1): 57-66. PMID: 25572480, DOI: 10.2217/imt.14.103, ISSN: 1750-7448.

Richmond BW, Richter K, King LE, Drake WP. Resolution of chronic ocular sarcoidosis with antimycobacterial therapy. Case Rep Intern Med. 2014; 1(2): PMID: 25580448, PMCID: PMC4286311, DOI: 10.5430/crim.v1n2p216, ISSN: 2332-7243.

Drake WP, Richmond BW, Oswald-Richter K, Yu C, Isom JM, Worrell JA, Shipley GR. Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2013 Nov 11/25/2013; 30(3): 201-11. PMID: 24284293, PMCID: PMC3929334, ISSN: 1124-0490.

Drake WP, Oswald-Richter K, Richmond BW, Isom J, Burke VE, Algood H, Braun N, Taylor T, Pandit KV, Aboud C, Yu C, Kaminski N, Boyd AS, King LE. Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study. JAMA Dermatol. 2013 Sep; 149(9): 1040-9. PMID: 23863960, PMCID: PMC3927541, PII: 1714665, DOI: 10.1001/jamadermatol.2013.4646, ISSN: 2168-6084.

Oswald-Richter KA, Richmond BW, Braun NA, Isom J, Abraham S, Taylor TR, Drake JM, Culver DA, Wilkes DS, Drake WP. Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis. J. Immunol [print-electronic]. 2013 Jun 6/1/2013; 190(11): 5446-53. PMID: 23630356, PMCID: PMC3660530, PII: jimmunol.1202891, DOI: 10.4049/jimmunol.1202891, ISSN: 1550-6606.

Richmond BW, Ploetze K, Isom J, Chambers-Harris I, Braun NA, Taylor T, Abraham S, Mageto Y, Culver DA, Oswald-Richter KA, Drake WP. Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN-¿ expression. J. Clin. Immunol [print-electronic]. 2013 Feb; 33(2): 446-55. PMID: 23073617, PMCID: PMC3850764, DOI: 10.1007/s10875-012-9817-6, ISSN: 1573-2592.

Oswald-Richter KA, Beachboard DC, Seeley EH, Abraham S, Shepherd BE, Jenkins CA, Culver DA, Caprioli RM, Drake WP. Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL. J. Clin. Immunol [print-electronic]. 2012 Oct; 32(5): 1129-40. PMID: 22552860, PMCID: PMC3526106, DOI: 10.1007/s10875-012-9700-5, ISSN: 1573-2592.

Noth I, Gibson KF, Drake WP. Where next for gene expression profiling? So much promise [editorial]. Am. J. Respir. Crit. Care Med. 2011 Nov 11/15/2011; 184(10): 1102-3. PMID: 22086986, PII: 184/10/1102, DOI: 10.1164/rccm.201109-1612ED, ISSN: 1535-4970.

Swaisgood CM, Oswald-Richter K, Moeller SD, Klemenc JM, Ruple LM, Farver CF, Drake JM, Culver DA, Drake WP. Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2011 Feb; 44(2): 166-74. PMID: 20348207, PMCID: PMC3049230, PII: 2009-0350OC, DOI: 10.1165/rcmb.2009-0350OC, ISSN: 1535-4989.

Richmond BW, Drake WP. Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial research. Curr Opin Pulm Med. 2010 Sep; 16(5): 461-4. PMID: 20473167, DOI: 10.1097/MCP.0b013e32833af7e8, ISSN: 1531-6971.

Oswald-Richter KA, Drake WP. The etiologic role of infectious antigens in sarcoidosis pathogenesis. Semin Respir Crit Care Med [print-electronic]. 2010 Aug; 31(4): 375-9. PMID: 20665387, DOI: 10.1055/s-0030-1262205, ISSN: 1098-9048.

Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A, Newman LS, Drake WP. Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. J. Clin. Immunol [print-electronic]. 2010 Jan; 30(1): 157-66. PMID: 19536643, PMCID: PMC2821522, DOI: 10.1007/s10875-009-9311-y, ISSN: 1573-2592.

Chambers IR, Cone TR, Oswald-Richter K, Drake WP. Enzyme-linked immunospot assay (ELISPOT): Quantification of Th-1 cellular immune responses against microbial antigens. J Vis Exp. 2010; (45): PMID: 21178951, PMCID: PMC3159592, PII: 2221, DOI: 10.3791/2221, ISSN: 1940-087X.

Oswald-Richter KA, Beachboard DC, Zhan X, Gaskill CF, Abraham S, Jenkins C, Culver DA, Drake W. Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis. Respir. Res. 2010; 11: 161. PMID: 21092305, PMCID: PMC2999599, PII: 1465-9921-11-161, DOI: 10.1186/1465-9921-11-161, ISSN: 1465-993X.

Idell S, Jun Na M, Liao H, Gazar AE, Drake W, Lane KB, Koenig K, Komissarov A, Tucker T, Light RW. Single-chain urokinase in empyema induced by Pasturella multocida. Exp. Lung Res. 2009 Oct; 35(8): 665-81. PMID: 19895321, PII: 10.3109/01902140902833277, DOI: 10.3109/01902140902833277, ISSN: 1521-0499.

Oswald-Richter KA, Culver DA, Hawkins C, Hajizadeh R, Abraham S, Shepherd BE, Jenkins CA, Judson MA, Drake WP. Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis. Infect. Immun [print-electronic]. 2009 Sep; 77(9): 3740-8. PMID: 19596780, PMCID: PMC2738026, PII: IAI.00142-09, DOI: 10.1128/IAI.00142-09, ISSN: 1098-5522.

Moss J, Zic J, Drake W. Mycobacterial infection masquerading as cutaneous sarcoidosis. Clin. Exp. Dermatol [print-electronic]. 2009 Jul; 34(5): e199-201. PMID: 19040506, PII: CED2983, DOI: 10.1111/j.1365-2230.2008.02983.x, ISSN: 1365-2230.

Drake WP. When a commensal becomes a pathogen [editorial]. Sarcoidosis Vasc Diffuse Lung Dis. 2008 Sep; 25(1): 10-1. PMID: 19070255, ISSN: 1124-0490.

Allen SS, Evans W, Carlisle J, Hajizadeh R, Nadaf M, Shepherd BE, Pride DT, Johnson JE, Drake WP. Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses. Respir. Res. 2008; 9: 36. PMID: 18439270, PMCID: PMC2383887, PII: 1465-9921-9-36, DOI: 10.1186/1465-9921-9-36, ISSN: 1465-993X.

Drake W. Infectious antigens may play a role in the pathogenesis of sarcoidosis [editorial]. Medscape J Med [print-electronic]. 2008; 10(12): 288. PMID: 19242594, PMCID: PMC2644019, ISSN: 1934-1997.

Carlisle J, Evans W, Hajizadeh R, Nadaf M, Shepherd B, Ott RD, Richter K, Drake W. Multiple Mycobacterium antigens induce interferon-gamma production from sarcoidosis peripheral blood mononuclear cells. Clin. Exp. Immunol [print-electronic]. 2007 Dec; 150(3): 460-8. PMID: 17924974, PMCID: PMC2219367, PII: CEI3510, DOI: 10.1111/j.1365-2249.2007.03510.x, ISSN: 1365-2249.

Hajizadeh R, Sato H, Carlisle J, Nadaf MT, Evans W, Shepherd BE, Miller RF, Kalams SA, Drake WP. Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis. J. Clin. Immunol [print-electronic]. 2007 Jul; 27(4): 445-54. PMID: 17357846, PMCID: PMC3962023, DOI: 10.1007/s10875-007-9080-4, ISSN: 0271-9142.

Drake WP, Dhason MS, Nadaf M, Shepherd BE, Vadivelu S, Hajizadeh R, Newman LS, Kalams SA. Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis. Infect. Immun [print-electronic]. 2007 Jan; 75(1): 527-30. PMID: 17088357, PMCID: PMC1828402, PII: IAI.00732-06, DOI: 10.1128/IAI.00732-06, ISSN: 0019-9567.

Drake WP, Newman LS. Mycobacterial antigens may be important in sarcoidosis pathogenesis. Curr Opin Pulm Med. 2006 Sep; 12(5): 359-63. PMID: 16926652, PII: 00063198-200609000-00015, DOI: 10.1097/01.mcp.0000239554.01068.94, ISSN: 1070-5287.

Blaha MJ, Kusz KL, Drake W, Elasy TA. Hypertension prevalence awareness, treatment and control in North Nashville. Tenn Med. 2006 Apr; 99(4): 35-7. PMID: 16704130, ISSN: 1088-6222.

Zhiwen Zhu, Hawthorne ML, Guo Y, Drake WP, Bilaceroglu S, Misra HL, Light RW. “Tissue Plasminogen Activator combined with human recombinant DNase is effective therapy for empyema in a rabbit model.”. Chest. 2006; 129: 1577-83.

Drake WP, Byrd VM, Olsen NJ. Reactivation of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for acquired immunodeficiency syndrome. J Clin Rheumatol. 2003 Jun; 9(3): 176-80. PMID: 17041454, PII: 00124743-200306000-00009, DOI: 10.1097/01.RHU.0000073591.34503.4e, ISSN: 1076-1608.

Drake WP, Pei Z, Pride DT, Collins RD, Cover TL, Blaser MJ. Molecular analysis of sarcoidosis tissues for mycobacterium species DNA. Emerging Infect. Dis. 2002 Nov; 8(11): 1334-41. PMID: 12453366, PMCID: PMC2738555, DOI: 10.3201/eid0811.020318, ISSN: 1080-6040.

Lucas GM, Lechtzin N, Puryear DW, Yau LL, Flexner CW, Moore RD. Vancomycin-resistant and vancomycin-susceptible enterococcal bacteremia: comparison of clinical features and outcomes. Clin. Infect. Dis. 1998 May; 26(5): 1127-33. PMID: 9597241, ISSN: 1058-4838.

Wilson GJ, Wetzel JD, Puryear W, Bassel-Duby R, Dermody TS. Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability. J. Virol. 1996 Oct; 70(10): 6598-606. PMID: 8794294, PMCID: PMC190700, ISSN: 0022-538X.

Schlundt DG, Pichert JW, Rea MR, Puryear W, Penha ML, Kline SS. Situational obstacles to adherence for adolescents with diabetes. Diabetes Educ. 1994 May; 20(3): 207-11. PMID: 7851234, ISSN: 0145-7217.

Drake ME. Deafness, dysesthesia, depression, diarrhea, dropsy, and death: the case for sarcoidosis in Ludwig van Beethoven. Neurology. 1994 Mar; 44(3 Pt 1): 562-5. PMID: 7632190, ISSN: 0028-3878.

Cover TL, Puryear W, Perez-Perez GI, Blaser MJ. Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin. Infect. Immun. 1991 Apr; 59(4): 1264-70. PMID: 2004808, PMCID: PMC257837, ISSN: 0019-9567.