David Lee Gorden, M.D.


Faculty Appointments
Professor of Surgery Professor of Pharmacology
M.D., Medicine , Vanderbilt University, Nashville, TennesseeA.B., Brown University, Providence, Rhode Island
Office Address
801 Oxford House
1313 21st Ave. S.
Nashville, TN 37232-4753
Research Description
We are particularly interested in tumor- microenvironment interactions in primary and metastatic tumors of the liver.
Research Keywords
Martin MD, Kremers GJ, Short KW, Rocheleau JV, Xu L, Piston DW, Matrisian LM, Gorden DL. Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. Mol. Cancer Res [print-electronic]. 2010 Oct; 8(10): 1319-27. PMID: 20724460, PMCID: PMC2981168, PII: 1541-7786.MCR-09-0551, DOI: 10.1158/1541-7786.MCR-09-0551, ISSN: 1557-3125.

Kappa SF, Gorden DL, Davidson MA, Wright JK, Guillamondegui OD. Intraoperative blood loss predicts hemorrhage-related reoperation after orthotopic liver transplantation. Am Surg. 2010 Sep; 76(9): 969-73. PMID: 20836345, ISSN: 0003-1348.

Uddin MJ, Crews BC, Blobaum AL, Kingsley PJ, Gorden DL, McIntyre JO, Matrisian LM, Subbaramaiah K, Dannenberg AJ, Piston DW, Marnett LJ. Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res. 2010 May 5/1/2010; 70(9): 3618-27. PMID: 20430759, PMCID: PMC2864539, PII: 70/9/3618, DOI: 10.1158/0008-5472.CAN-09-2664, ISSN: 1538-7445.

Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK. Antimetastatic role of Smad4 signaling in colorectal cancer. Gastroenterology [print-electronic]. 2010 Mar; 138(3): 969-80.e1. PMID: 19909744, PMCID: PMC2831103, PII: S0016-5085(09)01963-5, DOI: 10.1053/j.gastro.2009.11.004, ISSN: 1528-0012.

VanSaun MN, Lee IK, Washington MK, Matrisian L, Gorden DL. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am. J. Pathol [print-electronic]. 2009 Jul; 175(1): 355-64. PMID: 19541928, PMCID: PMC2708821, PII: S0002-9440(10)60550-0, DOI: 10.2353/ajpath.2009.080703, ISSN: 1525-2191.

Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, Rubin JE, Pierre KP, Gorden DL, Chari RS. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis. Ann. Surg. Oncol [print-electronic]. 2009 Apr; 16(4): 1043-50. PMID: 19165543, DOI: 10.1245/s10434-009-0325-8, ISSN: 1534-4681.

Tessier DJ, Iglesias R, Chapman WC, Kercher K, Matthews BD, Gorden DL, Brunt LM. Previously unreported high-grade complications of adrenalectomy. Surg Endosc [print-electronic]. 2009 Jan; 23(1): 97-102. PMID: 18443863, DOI: 10.1007/s00464-008-9947-3, ISSN: 1432-2218.

Lee IK, Jung SE, Gorden DL, Lee YS, Jung DY, Oh ST, Kim JG, Jeon HM, Chang SK. The diagnostic criteria for right colonic diverticulitis: prospective evaluation of 100 patients. Int J Colorectal Dis [print-electronic]. 2008 Dec; 23(12): 1151-7. PMID: 18704462, DOI: 10.1007/s00384-008-0512-2, ISSN: 0179-1958.

Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JO. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med. 2008 Sep; 60(3): 718-26. PMID: 18727087, PMCID: PMC2646120, DOI: 10.1002/mrm.21724, ISSN: 1522-2594.

Castaldo ET, Earl TM, Chari RS, Gorden DL, Merchant NB, Wright JK, Feurer ID, Pinson CW. A clinical comparative analysis of crush/clamp, stapler, and dissecting sealer hepatic transection methods. HPB (Oxford). 2008; 10(5): 321-6. PMID: 18982146, PMCID: PMC2575677, DOI: 10.1080/13651820802320040, ISSN: 1365-182X.

Gorden DL, Fingleton B, Crawford HC, Jansen DE, Lepage M, Matrisian LM. Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int. J. Cancer. 2007 Aug 8/1/2007; 121(3): 495-500. PMID: 17417772, DOI: 10.1002/ijc.22594, ISSN: 0020-7136.

Lundquist AL, Chari RS, Wood JH, Miller GG, Schaefer HM, Raiford DS, Wright KJ, Gorden DL. Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and literature review. Liver Transpl. 2007 May; 13(5): 647-50. PMID: 17377915, DOI: 10.1002/lt.21098, ISSN: 1527-6465.

Nicoud IB, Jones CM, Pierce JM, Earl TM, Matrisian LM, Chari RS, Gorden DL. Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer Res. 2007 Mar 3/15/2007; 67(6): 2720-8. PMID: 17363593, PII: 67/6/2720, DOI: 10.1158/0008-5472.CAN-06-3923, ISSN: 0008-5472.

Castaldo ET, Pinson CW, Feurer ID, Wright JK, Gorden DL, Kelly BS, Chari RS. Continuous versus interrupted suture for end-to-end biliary anastomosis during liver transplantation gives equal results. Liver Transpl. 2007 Feb; 13(2): 234-8. PMID: 17256781, DOI: 10.1002/lt.20986, ISSN: 1527-6465.

Koller FL, Geevarghese SK, Gorden DL. Liver transplantation for hepatocellular carcinoma: current role and future opportunities. Curr. Pharm. Des. 2007; 13(32): 3265-73. PMID: 18045177, ISSN: 1873-4286.

Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Jan 1/31/2006; 103(5): 1492-7. PMID: 16432186, PMCID: PMC1360588, PII: 0510562103, DOI: 10.1073/pnas.0510562103, ISSN: 0027-8424.

Schrager JJ, Vnencak-Jones CL, Graber SE, Neff AT, Chari RS, Wright KJ, Pinson CW, Stewart JH, Gorden DL. Use of short tandem repeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation. 2006 Jan 1/15/2006; 81(1): 21-5. PMID: 16421472, PII: 00007890-200601150-00006, ISSN: 0041-1337.

Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM. Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res. 2006 Jan 1/1/2006; 66(1): 259-66. PMID: 16397239, PMCID: PMC1360653, PII: 66/1/259, DOI: 10.1158/0008-5472.CAN-05-2502, ISSN: 0008-5472.

Thomas KT, Gorden DL, Chari RS, Wright JK, Feurer ID, Wright Pinson C. Biliary reconstruction using non-penetrating, tissue everting clips versus conventional sewn biliary anastomosis in liver transplantation. HPB (Oxford). 2006; 8(2): 132-6. PMID: 18333261, PMCID: PMC2131420, DOI: 10.1080/13651820510037620, ISSN: 1365-182X.

Austin MT, Feurer ID, Chari RS, Gorden DL, Wright JK, Pinson CW. Survival after pediatric liver transplantation: why does living donation offer an advantage?. Arch Surg. 2005 May; 140(5): 465-70; discussion 470. PMID: 15897442, PII: 140/5/465, DOI: 10.1001/archsurg.140.5.465, ISSN: 0004-0010.

Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden DL, Chari RS, Wright JK, Washington K, Pinson CW. Effective treatment of biliary cystadenoma. Ann. Surg. 2005 May; 241(5): 769-73; discussion 773. PMID: 15849512, PMCID: PMC1357131, PII: 00000658-200505000-00010, ISSN: 0003-4932.

Moore DE, Feurer ID, Speroff T, Gorden DL, Wright JK, Chari RS, Pinson CW. Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg. 2005 Mar; 140(3): 273-7. PMID: 15781792, PII: 140/3/273, DOI: 10.1001/archsurg.140.3.273, ISSN: 0004-0010.

Moore DE, Feurer ID, Rodgers S, Shaffer D, Nylander W, Gorden DL, Chari RS, Wright JK, Pinson CW. Is there racial disparity in outcomes after solid organ transplantation?. Am. J. Surg. 2004 Nov; 188(5): 571-4. PMID: 15546572, PII: S0002-9610(04)00366-6, DOI: 10.1016/j.amjsurg.2004.07.033, ISSN: 0002-9610.

Anderson CD, Meranze S, Bream P, Gorden DL, Wright JK, Pinson CW, Chari RS. Contralateral portal vein embolization for hepatectomy in the setting of hepatic steatosis. Am Surg. 2004 Jul; 70(7): 609-12. PMID: 15279184, ISSN: 0003-1348.

Moore DE, Feurer ID, Holzman MD, Wudel LJ, Strickland C, Gorden DL, Chari R, Wright JK, Pinson CW. Long-term detrimental effect of bile duct injury on health-related quality of life. Arch Surg. 2004 May; 139(5): 476-81; discussion 481. PMID: 15136346, PII: 139/5/476, DOI: 10.1001/archsurg.139.5.476, ISSN: 0004-0010.

Moore D, Feurer I, Speroff T, Shaffer D, Nylander W, Kizilisik T, Butler J, Awad J, Gorden DL, Chari R, Wright JK, Pinson CW. Survival and quality of life after organ transplantation in veterans and nonveterans. Am. J. Surg. 2003 Nov; 186(5): 476-80. PMID: 14599610, PII: S0002961003003532, ISSN: 0002-9610.

Gorden DL, Mandriota SJ, Montesano R, Orci L, Pepper MS. Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation. 1997 Feb 2/15/1997; 63(3): 436-43. PMID: 9039936, ISSN: 0041-1337.

Gorden DL, Robert A, Moncada VY, Taylor SI, Mühlhauser J, Carpentier JL. Cell surface alteration in Epstein-Barr virus-transformed cells from patients with extreme insulin resistance. Diabetes. 1990 Aug; 39(8): 924-7. PMID: 2165004, ISSN: 0012-1797.