Bibhash C. Paria, Ph.D.

Associate Professor

bc.paria@vanderbilt.edu

Visit Lab Site


Faculty Appointments
Associate Professor of Pediatrics
Education
Ph.D., Reproduction, University of Calcutta, Calcutta, IndiaM.Sc., Physiology, University of Calcutta, Calcutta, IndiaB.Sc., Physiology, University of Calcutta, Calcutta, India
Office Address
1055C MRB IV/Light Hall
2215 B. Garland Avenue
Nashville, TN 37232-6182
Research Description
1) Endotoxin detoxyfication strategy: A therapeutic option to prevent pregnancy complications induced by bacterial infection
Various global health organizations (e.g. WHO, UNICEF, GAPPS, MOD, BWF, NIH and others) have prioritized their research emphasis towards: 1) unfolding underlying mechanisms of all types of pregnancy complications; and 2) inventing treatment strategies to prevent pregnancy complications as well as to reduce the high rate of mortality and morbidity of preemies . A global analysis of etiologies of stillbirth and preterm birth revealed that beside genetical defects of the embryo, infection either in maternal reproductive or non-reproductive tissues is the next most common risk factor for adverse pregnancy outcomes.


2) Influence of implanting blastocyst in creation of a uterine decidual barrier to escape from maternal dangers:
Circumstantial evidence suggests that upon initiation of implantation, blastocysts help to create a uterine decidual barrier to escape from maternal dangers. However, the molecular structure of the decidual barrier and contribution of embryo to create this barrier is not elucidated. Our interest is to study the direct trophoblastic influences in the creation of tight junctional barrier between decidual cells in a murine model. Our hypothesis is that trophoblast cells of an implanted blastocyst influence the formation of a uterine decidual permeability barrier that maximizes protection of semi-allogenic embryo from mother’s immune system. We have defined that 1) the decidua of both the mouse and hamster expresses tight junctional components that regulate paracellular permeability barrier for macromolecules; 2) tight junction formation in the decidua is primarily regulated by trophoblast cells of the embryo. These findings suggest that the embryo influences decidual barrier formation for its own defense against maternal harmful macromolecules.

3) Molecules involve in the initiation of progesterone-dependent implantation in hamsters
Although progesterone is an absolute requirement for human implantation, it has become controversial whether ovarian estrogen is also a requirement. It is also unknown whether delayed implantation occurs in humans. Thus, the question remains answered regarding the mechanism by which progesterone alone regulates uterine and embryonic functions for implantation in many species. It is also not clear whether species-specific differential steroid hormonal requirements are reflected in differential regulation of local implantation-specific factors. We observed that heparin-binding EGF-like growth factor HB-EGF), amphiregulin, leukemia inhibitory factor (Lif), indian hedgehog genes are expressed in the hamster uterus in a spatiotemporal implantation specific manner. To our surprise, we noted that while indian hedgehog and Lif genes expressions in the hamster uterus are regulated by progesterone and estrogen, respectively, as observed in the mice, hamster uterine expression of HB-EGF is regulated by estradiol-17ß, but not by progesterone. Furthermore, we observed no hormonal regulation of amphiregulin gene in the hamster uterus and no expression of this gene during the period of uterine receptivity. These results suggest that caution should be used when drawing conclusions about the importance of a molecule for a specific event based on studies performed in a single animal. In this regard, it is noteworthy to mention that we have revealed for the first-time genes that are associated with the progesterone-dependent implantation process in hamsters using microarray analysis.
Research Keywords
Mechanisms of embryo development, embryo implantation, uterine decidualization, early pregnancy loss, preterm birth, maternal-fetal interface
Publications
Robuck MF, O'Brien CM, Knapp KM, Shay SD, West JD, Newton JM, Slaughter JC, Paria BC, Reese J, Herington JL. Monitoring uterine contractility in mice using a transcervical intrauterine pressure catheter. Reproduction [print-electronic]. 2018 May; 155(5): 447-56. PMID: 29500186, PMCID: PMC5903945, PII: REP-17-0647, DOI: 10.1530/REP-17-0647, ISSN: 1741-7899.

Nguyen JQM, McWade M, Thomas G, Beddard BT, Herington JL, Paria BC, Schwartz HS, Halpern JL, Holt GE, Mahadevan-Jansen A. Development of a modular fluorescence overlay tissue imaging system for wide-field intraoperative surgical guidance. J Med Imaging (Bellingham) [print-electronic]. 2018 Apr; 5(2): 21220. PMID: 29531968, PMCID: PMC5833937, PII: 17276SSRRR, DOI: 10.1117/1.JMI.5.2.021220, ISSN: 2329-4302.

Herington JL, O'Brien C, Robuck MF, Lei W, Brown N, Slaughter JC, Paria BC, Mahadevan-Jansen A, Reese J. Prostaglandin-Endoperoxide Synthase 1 Mediates the Timing of Parturition in Mice Despite Unhindered Uterine Contractility. Endocrinology. 2018 Jan 1/1/2018; 159(1): 490-505. PMID: 29029054, PMCID: PMC5761592, PII: 4210435, DOI: 10.1210/en.2017-00647, ISSN: 1945-7170.

O'Brien CM, Herington JL, Brown N, Pence IJ, Paria BC, Slaughter JC, Reese J, Mahadevan-Jansen A. In vivo Raman spectral analysis of impaired cervical remodeling in a mouse model of delayed parturition. Sci Rep. 2017 Jul 7/28/2017; 7(1): 6835. PMID: 28754971, PMCID: PMC5533720, PII: 10.1038/s41598-017-07047-5, DOI: 10.1038/s41598-017-07047-5, ISSN: 2045-2322.

Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming. Matrix Biol [print-electronic]. 2017 Jan; 57-58: 347-65. PMID: 27619726, PMCID: PMC5328942, PII: S0945-053X(16)30074-9, DOI: 10.1016/j.matbio.2016.09.005, ISSN: 1569-1802.

Herington JL, Guo Y, Reese J, Paria BC. Gene profiling the window of implantation: Microarray analyses from human and rodent models. J Reprod Health Med [print-electronic]. 2016 Dec; 2(Suppl 2): S19-S25. PMID: 28239559, PMCID: PMC5321051, DOI: 10.1016/j.jrhm.2016.11.006, ISSN: 2214-420X.

Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG. Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy. Data Brief. 2016 Dec; 9: 931-9. PMID: 27896299, PMCID: PMC5118616, PII: S2352-3409(16)30660-6, DOI: 10.1016/j.dib.2016.10.033, ISSN: 2352-3409.

Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility. PLoS ONE. 2015; 10(11): e0143243. PMID: 26600013, PMCID: PMC4658040, PII: PONE-D-15-12311, DOI: 10.1371/journal.pone.0143243, ISSN: 1932-6203.

Lei W, Ni H, Herington J, Reese J, Paria BC. Alkaline phosphatase protects lipopolysaccharide-induced early pregnancy defects in mice. PLoS ONE. 2015; 10(4): e0123243. PMID: 25910276, PMCID: PMC4409290, PII: PONE-D-15-04551, DOI: 10.1371/journal.pone.0123243, ISSN: 1932-6203.

Lei W, Herington J, Galindo CL, Ding T, Brown N, Reese J, Paria BC. Cross-species transcriptomic approach reveals genes in hamster implantation sites. Reproduction [print-electronic]. 2014 Dec; 148(6): 607-21. PMID: 25252651, PMCID: PMC4230993, PII: REP-14-0388, DOI: 10.1530/REP-14-0388, ISSN: 1741-7899.

Vucovich MM, Cotton RB, Shelton EL, Goettel JA, Ehinger NJ, Poole SD, Brown N, Wynn JL, Paria BC, Slaughter JC, Clark RH, Rojas MA, Reese J. Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): H732-40. PMID: 24993047, PMCID: PMC4187398, PII: ajpheart.00838.2013, DOI: 10.1152/ajpheart.00838.2013, ISSN: 1522-1539.

Shelton EL, Ector G, Galindo CL, Hooper CW, Brown N, Wilkerson I, Pfaltzgraff ER, Paria BC, Cotton RB, Stoller JZ, Reese J. Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone. Physiol. Genomics [print-electronic]. 2014 Jul 7/1/2014; 46(13): 457-66. PMID: 24790087, PMCID: PMC4080279, PII: physiolgenomics.00171.2013, DOI: 10.1152/physiolgenomics.00171.2013, ISSN: 1531-2267.

O'Brien CM, Vargis E, Paria BC, Bennett KA, Mahadevan-Jansen A, Reese J. Raman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo. Acta Paediatr [print-electronic]. 2014 Jul; 103(7): 715-21. PMID: 24628401, PMCID: PMC4048629, DOI: 10.1111/apa.12630, ISSN: 1651-2227.

Timmons BC, Reese J, Socrate S, Ehinger N, Paria BC, Milne GL, Akins ML, Auchus RJ, McIntire D, House M, Mahendroo M. Prostaglandins are essential for cervical ripening in LPS-mediated preterm birth but not term or antiprogestin-driven preterm ripening. Endocrinology [print-electronic]. 2014 Jan; 155(1): 287-98. PMID: 24189143, PMCID: PMC3868800, PII: en.2013-1304, DOI: 10.1210/en.2013-1304, ISSN: 1945-7170.

Cotton RB, Shah LP, Poole SD, Ehinger NJ, Brown N, Shelton EL, Slaughter JC, Baldwin HS, Paria BC, Reese J. Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism. J. Mol. Cell. Cardiol [print-electronic]. 2013 Jun; 59: 86-94. PMID: 23454087, PMCID: PMC3646934, PII: S0022-2828(13)00067-9, DOI: 10.1016/j.yjmcc.2013.02.010, ISSN: 1095-8584.

Lei W, Nguyen H, Brown N, Ni H, Kiffer-Moreira T, Reese J, Millán JL, Paria BC. Alkaline phosphatases contribute to uterine receptivity, implantation, decidualization, and defense against bacterial endotoxin in hamsters. Reproduction [electronic-print]. 2013; 146(5): 419-32. PMID: 23929901, PMCID: PMC3805369, PII: REP-13-0153, DOI: 10.1530/REP-13-0153, ISSN: 1741-7899.

Vargis E, Brown N, Williams K, Al-Hendy A, Paria BC, Reese J, Mahadevan-Jansen A. Detecting biochemical changes in the rodent cervix during pregnancy using Raman spectroscopy. Ann Biomed Eng [print-electronic]. 2012 Aug; 40(8): 1814-24. PMID: 22411265, PMCID: PMC3739433, DOI: 10.1007/s10439-012-0541-4, ISSN: 1573-9686.

Luan L, Ding T, Stinnett A, Reese J, Paria BC. Adherens junction proteins in the hamster uterus: their contributions to the success of implantation. Biol. Reprod [print-electronic]. 2011 Nov; 85(5): 996-1004. PMID: 21753191, PMCID: PMC3197917, PII: biolreprod.110.090126, DOI: 10.1095/biolreprod.110.090126, ISSN: 1529-7268.

Brown N, Morrow JD, Slaughter JC, Paria BC, Reese J. Restoration of on-time embryo implantation corrects the timing of parturition in cytosolic phospholipase A2 group IVA deficient mice. Biol. Reprod [print-electronic]. 2009 Dec; 81(6): 1131-8. PMID: 19684335, PMCID: PMC2802236, PII: biolreprod.109.079061, DOI: 10.1095/biolreprod.109.079061, ISSN: 1529-7268.

Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev. Biol [print-electronic]. 2008 Jun 6/1/2008; 318(1): 112-25. PMID: 18423437, PMCID: PMC2442465, PII: S0012-1606(08)00212-1, DOI: 10.1016/j.ydbio.2008.03.008, ISSN: 1095-564X.

Reese J, Wang H, Ding T, Paria BC. The hamster as a model for embryo implantation: insights into a multifaceted process. Semin. Cell Dev. Biol [print-electronic]. 2008 Apr; 19(2): 194-203. PMID: 18178492, PMCID: PMC2288742, PII: S1084-9521(07)00194-2, DOI: 10.1016/j.semcdb.2007.11.001, ISSN: 1084-9521.

Zhang Q, Paria BC. Importance of uterine cell death, renewal, and their hormonal regulation in hamsters that show progesterone-dependent implantation. Endocrinology [print-electronic]. 2006 May; 147(5): 2215-27. PMID: 16469810, PMCID: PMC1456201, PII: en.2005-1555, DOI: 10.1210/en.2005-1555, ISSN: 0013-7227.

Deb K, Reese J, Paria BC. Methodologies to study implantation in mice. Methods Mol. Med. 2006; 121: 9-34. PMID: 16251731, PII: 1-59259-983-4:007, ISSN: 1543-1894.

Brown N, Deb K, Paria BC, Das SK, Reese J. Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol. Reprod [print-electronic]. 2004 Dec; 71(6): 2003-11. PMID: 15306553, PII: biolreprod.104.031864, DOI: 10.1095/biolreprod.104.031864, ISSN: 0006-3363.

Wang X, Su Y, Deb K, Raposo M, Morrow JD, Reese J, Paria BC. Prostaglandin E2 is a product of induced prostaglandin-endoperoxide synthase 2 and microsomal-type prostaglandin E synthase at the implantation site of the hamster. J. Biol. Chem [print-electronic]. 2004 Jul 7/16/2004; 279(29): 30579-87. PMID: 15078866, PII: M400573200, DOI: 10.1074/jbc.M400573200, ISSN: 0021-9258.

Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, Wang H. Molecular cues to implantation. Endocr. Rev. 2004 Jun; 25(3): 341-73. PMID: 15180948, PII: 25/3/341, DOI: 10.1210/er.2003-0020, ISSN: 0163-769X.

Tan Y, Li M, Cox S, Davis MK, Tawfik O, Paria BC, Das SK. HB-EGF directs stromal cell polyploidy and decidualization via cyclin D3 during implantation. Dev. Biol. 2004 Jan 1/1/2004; 265(1): 181-95. PMID: 14697362, PMCID: PMC4277116, PII: S0012160603005712, ISSN: 0012-1606.

Wang X, Matsumoto H, Zhao X, Das SK, Paria BC. Embryonic signals direct the formation of tight junctional permeability barrier in the decidualizing stroma during embryo implantation. J. Cell. Sci [print-electronic]. 2004 Jan 1/1/2004; 117(Pt 1): 53-62. PMID: 14627626, PII: jcs.00826, DOI: 10.1242/jcs.00826, ISSN: 0021-9533.

Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, Dey SK. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Dec 12/9/2003; 100(25): 14914-9. PMID: 14645706, PMCID: PMC299852, PII: 2436379100, DOI: 10.1073/pnas.2436379100, ISSN: 0027-8424.

Ma WG, Song H, Das SK, Paria BC, Dey SK. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Mar 3/4/2003; 100(5): 2963-8. PMID: 12601161, PMCID: PMC151449, PII: 0530162100, DOI: 10.1073/pnas.0530162100, ISSN: 0027-8424.

Paria BC, Wang H, Dey SK. Endocannabinoid signaling in synchronizing embryo development and uterine receptivity for implantation. Chem. Phys. Lipids. 2002 Dec 12/31/2002; 121(1-2): 201-10. PMID: 12505701, PII: S0009308402001561, ISSN: 0009-3084.

Hough LB, Nalwalk JW, Stadel R, Timmerman H, Leurs R, Paria BC, Wang X, Dey SK. Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptors. J. Pharmacol. Exp. Ther. 2002 Oct; 303(1): 314-22. PMID: 12235266, DOI: 10.1124/jpet.102.036251, ISSN: 0022-3565.

Wang X, Wang H, Matsumoto H, Roy SK, Das SK, Paria BC. Dual source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster. Development. 2002 Sep; 129(17): 4125-34. PMID: 12163414, ISSN: 0950-1991.

Matsumoto H, Ma WG, Daikoku T, Zhao X, Paria BC, Das SK, Trzaskos JM, Dey SK. Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice. J. Biol. Chem [print-electronic]. 2002 Aug 8/9/2002; 277(32): 29260-7. PMID: 12034746, PII: M203996200, DOI: 10.1074/jbc.M203996200, ISSN: 0021-9258.

Paria BC, Reese J, Das SK, Dey SK. Deciphering the cross-talk of implantation: advances and challenges. Science. 2002 Jun 6/21/2002; 296(5576): 2185-8. PMID: 12077405, PII: 296/5576/2185, DOI: 10.1126/science.1071601, ISSN: 1095-9203.

Song H, Lim H, Paria BC, Matsumoto H, Swift LL, Morrow J, Bonventre JV, Dey SK. Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development. Development. 2002 Jun; 129(12): 2879-89. PMID: 12050136, ISSN: 0950-1991.

Nadano D, Sugihara K, Paria BC, Saburi S, Copeland NG, Gilbert DJ, Jenkins NA, Nakayama J, Fukuda MN. Significant differences between mouse and human trophinins are revealed by their expression patterns and targeted disruption of mouse trophinin gene. Biol. Reprod. 2002 Feb; 66(2): 313-21. PMID: 11804944, ISSN: 0006-3363.

Lim H, Song H, Paria BC, Reese J, Das SK, Dey SK. Molecules in blastocyst implantation: uterine and embryonic perspectives. Vitam. Horm. 2002; 64: 43-76. PMID: 11898397, ISSN: 0083-6729.

X Wang, H Wang, H Matsumoto, S. K. Roy, S. K. Das and B. C. Paria. Dual Source and target of heparin-binding EGF-like growth factor during the onset of implantation in the hamster. Development. 2002; 129: 4125-34.

Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J. Biol. Chem [print-electronic]. 2001 Nov 11/23/2001; 276(47): 44137-45. PMID: 11551965, PII: M107563200, DOI: 10.1074/jbc.M107563200, ISSN: 0021-9258.

Paria BC, Song H, Wang X, Schmid PC, Krebsbach RJ, Schmid HH, Bonner TI, Zimmer A, Dey SK. Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation. J. Biol. Chem [print-electronic]. 2001 Jun 6/8/2001; 276(23): 20523-8. PMID: 11279117, PII: M100679200, DOI: 10.1074/jbc.M100679200, ISSN: 0021-9258.

Paria BC, Ma W, Tan J, Raja S, Das SK, Dey SK, Hogan BL. Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc. Natl. Acad. Sci. U.S.A. 2001 Jan 1/30/2001; 98(3): 1047-52. PMID: 11158592, PMCID: PMC14706, PII: 98/3/1047, DOI: 10.1073/pnas.98.3.1047, ISSN: 0027-8424.

Paria BC, Song H, Dey SK. Implantation: molecular basis of embryo-uterine dialogue. Int. J. Dev. Biol. 2001; 45(3): 597-605. PMID: 11417904, ISSN: 0214-6282.

Paria BC, Dey SK. Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation. Chem. Phys. Lipids. 2000 Nov; 108(1-2): 211-20. PMID: 11106792, PII: S0009308400001973, ISSN: 0009-3084.

Suzuki N, Nadano D, Paria BC, Kupriyanov S, Sugihara K, Fukuda MN. Trophinin expression in the mouse uterus coincides with implantation and is hormonally regulated but not induced by implanting blastocysts. Endocrinology. 2000 Nov; 141(11): 4247-54. PMID: 11089559, DOI: 10.1210/endo.141.11.7738, ISSN: 0013-7227.

Das SK, Tan J, Raja S, Halder J, Paria BC, Dey SK. Estrogen targets genes involved in protein processing, calcium homeostasis, and Wnt signaling in the mouse uterus independent of estrogen receptor-alpha and -beta. J. Biol. Chem. 2000 Sep 9/15/2000; 275(37): 28834-42. PMID: 10893236, PII: M003827200, DOI: 10.1074/jbc.M003827200, ISSN: 0021-9258.

Reese J, Paria BC, Brown N, Zhao X, Morrow JD, Dey SK. Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse. Proc. Natl. Acad. Sci. U.S.A. 2000 Aug 8/15/2000; 97(17): 9759-64. PMID: 10944235, PMCID: PMC16938, PII: 97/17/9759, ISSN: 0027-8424.

Song H, Lim H, Das SK, Paria BC, Dey SK. Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. Mol. Endocrinol. 2000 Aug; 14(8): 1147-61. PMID: 10935540, DOI: 10.1210/mend.14.8.0498, ISSN: 0888-8809.

Zhao X, Ma W, Das SK, Dey SK, Paria BC. Blastocyst H(2) receptor is the target for uterine histamine in implantation in the mouse. Development. 2000 Jun; 127(12): 2643-51. PMID: 10821762, ISSN: 0950-1991.

Reese J, Binart N, Brown N, Ma WG, Paria BC, Das SK, Kelly PA, Dey SK. Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology. 2000 May; 141(5): 1872-81. PMID: 10803598, DOI: 10.1210/endo.141.5.7464, ISSN: 0013-7227.

Paria BC, Lim H, Das SK, Reese J, Dey SK. Molecular signaling in uterine receptivity for implantation. Semin. Cell Dev. Biol. 2000 Apr; 11(2): 67-76. PMID: 10873704, PII: S1084-9521(00)90153-8, DOI: 10.1006/scdb.2000.0153, ISSN: 1084-9521.

Halder JB, Zhao X, Soker S, Paria BC, Klagsbrun M, Das SK, Dey SK. Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis. 2000 Mar; 26(3): 213-24. PMID: 10705382, PII: 10.1002/(SICI)1526-968X(200003)26:3<213::AID-GENE7>3.0.CO;2-M, ISSN: 1526-954X.

Tan J, Paria BC, Dey SK, Das SK. Differential uterine expression of estrogen and progesterone receptors correlates with uterine preparation for implantation and decidualization in the mouse. Endocrinology. 1999 Nov; 140(11): 5310-21. PMID: 10537162, PMCID: PMC4280800, DOI: 10.1210/endo.140.11.7148, ISSN: 0013-7227.

Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD, DuBois RN, Trzaskos JM, Dey SK. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 1999 Jun 6/15/1999; 13(12): 1561-74. PMID: 10385625, PMCID: PMC316805, ISSN: 0890-9369.

Paria BC, Tan J, Lubahn DB, Dey SK, Das SK. Uterine decidual response occurs in estrogen receptor-alpha-deficient mice. Endocrinology. 1999 Jun; 140(6): 2704-10. PMID: 10342861, PMCID: PMC4273314, DOI: 10.1210/endo.140.6.6825, ISSN: 0013-7227.

Paria BC, Zhao X, Wang J, Das SK, Dey SK. Fatty-acid amide hydrolase is expressed in the mouse uterus and embryo during the periimplantation period. Biol. Reprod. 1999 May; 60(5): 1151-7. PMID: 10208977, ISSN: 0006-3363.

Paria BC, Elenius K, Klagsbrun M, Dey SK. Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. Development. 1999 May; 126(9): 1997-2005. PMID: 10101133, ISSN: 0950-1991.

Reese J, Brown N, Paria BC, Morrow J, Dey SK. COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period. Mol. Cell. Endocrinol. 1999 Apr 4/25/1999; 150(1-2): 23-31. PMID: 10411296, ISSN: 0303-7207.

Paria BC, Zhao X, Das SK, Dey SK, Yoshinaga K. Zonula occludens-1 and E-cadherin are coordinately expressed in the mouse uterus with the initiation of implantation and decidualization. Dev. Biol. 1999 Apr 4/15/1999; 208(2): 488-501. PMID: 10191061, PII: S0012-1606(99)99206-0, DOI: 10.1006/dbio.1999.9206, ISSN: 0012-1606.

Wang J, Paria BC, Dey SK, Armant DR. Stage-specific excitation of cannabinoid receptor exhibits differential effects on mouse embryonic development. Biol. Reprod. 1999 Apr; 60(4): 839-44. PMID: 10084956, ISSN: 0006-3363.

Das SK, Lim H, Paria BC, Dey SK. Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. J. Mol. Endocrinol. 1999 Feb; 22(1): 91-101. PMID: 9924184, ISSN: 0952-5041.

Paria BC, Lim H, Wang XN, Liehr J, Das SK, Dey SK. Coordination of differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse. Endocrinology. 1998 Dec; 139(12): 5235-46. PMID: 9832464, DOI: 10.1210/endo.139.12.6386, ISSN: 0013-7227.

Paria BC, Das N, Das SK, Zhao X, Dileepan KN, Dey SK. Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Endocrinology. 1998 Sep; 139(9): 3958-66. PMID: 9724051, DOI: 10.1210/endo.139.9.6173, ISSN: 0013-7227.

Paria BC, Ma W, Andrenyak DM, Schmid PC, Schmid HH, Moody DE, Deng H, Makriyannis A, Dey SK. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. Biol. Reprod. 1998 Jun; 58(6): 1490-5. PMID: 9623610, ISSN: 0006-3363.

Paria BC, Das SK, Dey SK. Embryo implantation requires estrogen-directed uterine preparation and catecholestrogen-mediated embyronic activation. Adv. Pharmacol. 1998; 42: 840-3. PMID: 9328028, ISSN: 1054-3589.

Das SK, Taylor JA, Korach KS, Paria BC, Dey SK, Lubahn DB. Estrogenic responses in estrogen receptor-alpha deficient mice reveal a distinct estrogen signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 1997 Nov 11/25/1997; 94(24): 12786-91. PMID: 9371753, PMCID: PMC24216, ISSN: 0027-8424.

Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Trzaskos JM, Dey SK. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell. 1997 Oct 10/17/1997; 91(2): 197-208. PMID: 9346237, PII: S0092-8674(00)80402-X, ISSN: 0092-8674.

Das SK, Lim H, Wang J, Paria BC, BazDresch M, Dey SK. Inappropriate expression of human transforming growth factor (TGF)-alpha in the uterus of transgenic mouse causes downregulation of TGF-beta receptors and delays the blastocyst-attachment reaction. J. Mol. Endocrinol. 1997 Jun; 18(3): 243-57. PMID: 9195478, ISSN: 0952-5041.

Schmid PC, Paria BC, Krebsbach RJ, Schmid HH, Dey SK. Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation. Proc. Natl. Acad. Sci. U.S.A. 1997 Apr 4/15/1997; 94(8): 4188-92. PMID: 9108127, PMCID: PMC20598, ISSN: 0027-8424.

Smith SE, French MM, Julian J, Paria BC, Dey SK, Carson DD. Expression of heparan sulfate proteoglycan (perlecan) in the mouse blastocyst is regulated during normal and delayed implantation. Dev. Biol. 1997 Apr 4/1/1997; 184(1): 38-47. PMID: 9142982, PII: S0012-1606(97)98521-3, DOI: 10.1006/dbio.1997.8521, ISSN: 0012-1606.

Dalton T, Paria BC, Fernando LP, Huet-Hudson YM, Dey SK, Andrews GK. Activation of the chicken metallothionein promoter by metals and oxidative stress in cultured cells and transgenic mice. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1997 Jan; 116(1): 75-86. PMID: 9080664, ISSN: 1096-4959.

Paria BC, Deutsch DD, Dey SK. The uterus is a potential site for anandamide synthesis and hydrolysis: differential profiles of anandamide synthase and hydrolase activities in the mouse uterus during the periimplantation period. Mol. Reprod. Dev. 1996 Oct; 45(2): 183-92. PMID: 8914076, PII: 10.1002/(SICI)1098-2795(199610)45:2<183::AID-MRD11>3.0.CO;2-2, DOI: 10.1002/(SICI)1098-2795(199610)45:2<183::AID-MRD11>3.0.CO;2-2, ISSN: 1040-452X.

Yang ZM, Paria BC, Dey SK. Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development. Biol. Reprod. 1996 Oct; 55(4): 756-61. PMID: 8879486, ISSN: 0006-3363.

Benson GV, Lim H, Paria BC, Satokata I, Dey SK, Maas RL. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development. 1996 Sep; 122(9): 2687-96. PMID: 8787743, ISSN: 0950-1991.

Strömstedt M, Keeney DS, Waterman MR, Paria BC, Conley AJ, Dey SK. Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis. Mol. Reprod. Dev. 1996 Apr; 43(4): 428-36. PMID: 9052933, PII: 10.1002/(SICI)1098-2795(199604)43:4<428::AID-MRD4>3.0.CO;2-R, DOI: 10.1002/(SICI)1098-2795(199604)43:4<428::AID-MRD4>3.0.CO;2-R, ISSN: 1040-452X.

Available Postdoctoral Position Details
Posted: 10/17/2018

We are currently seeking applicants for a postdoctoral fellow position. The project will involve elucidation of the mechanism(s) and prevention of lipopolysaccharide-induced early pregnancy complications. Thus, we are interested in eligible applicants with experience in molecular biology, immunology, uterine biology and/or pharmacology.