Patricia G. Yancey, Ph.D.

Research Assistant Professor

patricia.g.yancey@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., PATHOBIOLOGY, Wake Forest University, Winston-Salem, North CarolinaB.S., Averett University, Danville, Virginia
Office Address
318 PRB
2220 Pierce Ave
Nashville, FL 37232-6300
Publications
Linton MF, Tao H, Linton EF, Yancey PG. SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. Trends Endocrinol. Metab [print-electronic]. 2017 Jun; 28(6): 461-72. PMID: 28259375, PMCID: PMC5438771, PII: S1043-2760(17)30017-6, DOI: 10.1016/j.tem.2017.02.001, ISSN: 1879-3061.

Ormseth MJ, Yancey PG, Yamamoto S, Oeser AM, Gebretsadik T, Shintani A, Linton MF, Fazio S, Davies SS, Roberts LJ, Vickers KC, Raggi P, Kon V, Stein CM. Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. IJC Metab Endocr [print-electronic]. 2016 Dec; 13: 6-11. PMID: 28243578, PMCID: PMC5325720, DOI: 10.1016/j.ijcme.2016.08.002.

Linton MF, Babaev VR, Huang J, Linton EF, Tao H, Yancey PG. Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis. Circ. J [print-electronic]. 2016 Oct 10/25/2016; 80(11): 2259-68. PMID: 27725526, PMCID: PMC5459487, DOI: 10.1253/circj.CJ-16-0924, ISSN: 1347-4820.

Ormseth MJ, Yancey PG, Solus JF, Louis Bridges S, Curtis JR, Linton MF, Fazio S, Davies SS, Roberts LJ, Vickers KC, Kon V, Michael Stein C, . Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2016 Sep; 68(9): 2099-105. PMID: 26991245, PMCID: PMC5001900, DOI: 10.1002/art.39675, ISSN: 2326-5205.

Yamamoto S, Zhong J, Yancey PG, Zuo Y, Linton MF, Fazio S, Yang H, Narita I, Kon V. Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. Atherosclerosis [print-electronic]. 2015 Sep; 242(1): 56-64. PMID: 26184694, PMCID: PMC4850906, PII: S0021-9150(15)30016-2, DOI: 10.1016/j.atherosclerosis.2015.06.055, ISSN: 1879-1484.

Tao H, Yancey PG, Babaev VR, Blakemore JL, Zhang Y, Ding L, Fazio S, Linton MF. Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis. J. Lipid Res [print-electronic]. 2015 Aug; 56(8): 1449-60. PMID: 26059978, PMCID: PMC4513986, PII: jlr.M056689, DOI: 10.1194/jlr.M056689, ISSN: 1539-7262.

Guo L, Chen Z, Amarnath V, Yancey PG, Van Lenten BJ, Savage JR, Fazio S, Linton MF, Davies SS. Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts. Antioxid. Redox Signal [print-electronic]. 2015 Jun 6/20/2015; 22(18): 1633-45. PMID: 25751734, PMCID: PMC4485367, DOI: 10.1089/ars.2014.6078, ISSN: 1557-7716.

Tavori H, Su YR, Yancey PG, Giunzioni I, Wilhelm AJ, Blakemore JL, Zabalawi M, Linton MF, Sorci-Thomas MG, Fazio S. Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL. J. Lipid Res [print-electronic]. 2015 Mar; 56(3): 635-43. PMID: 25593328, PMCID: PMC4340310, PII: jlr.M056408, DOI: 10.1194/jlr.M056408, ISSN: 1539-7262.

Kaseda R, Jabs K, Hunley TE, Jones D, Bian A, Allen RM, Vickers KC, Yancey PG, Linton MF, Fazio S, Kon V. Dysfunctional high-density lipoproteins in children with chronic kidney disease. Metab. Clin. Exp [print-electronic]. 2015 Feb; 64(2): 263-73. PMID: 25467845, PMCID: PMC4277938, PII: S0026-0495(14)00329-1, DOI: 10.1016/j.metabol.2014.10.020, ISSN: 1532-8600.

Tavori H, Fan D, Blakemore JL, Yancey PG, Ding L, Linton MF, Fazio S. Serum proprotein convertase subtilisin/kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation. Circulation [print-electronic]. 2013 Jun 6/18/2013; 127(24): 2403-13. PMID: 23690465, PMCID: PMC3806304, PII: CIRCULATIONAHA.113.001592, DOI: 10.1161/CIRCULATIONAHA.113.001592, ISSN: 1524-4539.

Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V. Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J. Am. Coll. Cardiol [print-electronic]. 2012 Dec 12/11/2012; 60(23): 2372-9. PMID: 23141484, PII: S0735-1097(12)04651-7, DOI: 10.1016/j.jacc.2012.09.013, ISSN: 1558-3597.

Yamamoto S, Yancey PG, Zuo Y, Ma LJ, Kaseda R, Fogo AB, Ichikawa I, Linton MF, Fazio S, Kon V. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2011 Dec; 31(12): 2856-64. PMID: 21979434, PMCID: PMC3227118, PII: ATVBAHA.111.237198, DOI: 10.1161/ATVBAHA.111.237198, ISSN: 1524-4636.

Yamamoto S, Zuo Y, Ma J, Yancey PG, Hunley TE, Motojima M, Fogo AB, Linton MF, Fazio S, Ichikawa I, Kon V. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice. Nephrol. Dial. Transplant [print-electronic]. 2011 Aug; 26(8): 2491-7. PMID: 21245127, PMCID: PMC3203394, PII: gfq759, DOI: 10.1093/ndt/gfq759, ISSN: 1460-2385.

Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, Zhang J, Linton MF, Fazio S. Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Circulation [print-electronic]. 2011 Jul 7/26/2011; 124(4): 454-64. PMID: 21730304, PMCID: PMC3144781, PII: CIRCULATIONAHA.111.032268, DOI: 10.1161/CIRCULATIONAHA.111.032268, ISSN: 1524-4539.

Yancey PG, Blakemore J, Ding L, Fan D, Overton CD, Zhang Y, Linton MF, Fazio S. Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2010 Apr; 30(4): 787-95. PMID: 20150557, PMCID: PMC2845445, PII: ATVBAHA.109.202051, DOI: 10.1161/ATVBAHA.109.202051, ISSN: 1524-4636.

Fan D, Yancey PG, Qiu S, Ding L, Weeber EJ, Linton MF, Fazio S. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry [print-electronic]. 2008 Feb 2/12/2008; 47(6): 1631-9. PMID: 18197702, PMCID: PMC2732112, DOI: 10.1021/bi7016359, ISSN: 0006-2960.

Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation [print-electronic]. 2007 Sep 9/18/2007; 116(12): 1404-12. PMID: 17724261, PII: CIRCULATIONAHA.106.684704, DOI: 10.1161/CIRCULATIONAHA.106.684704, ISSN: 1524-4539.

Fan D, Qiu S, Overton CD, Yancey PG, Swift LL, Jerome WG, Linton MF, Fazio S. Impaired secretion of apolipoprotein E2 from macrophages. J. Biol. Chem [print-electronic]. 2007 May 5/4/2007; 282(18): 13746-53. PMID: 17341585, PII: M611754200, DOI: 10.1074/jbc.M611754200, ISSN: 0021-9258.

Yancey PG, Yu H, Linton MF, Fazio S. A pathway-dependent on apoE, ApoAI, and ABCA1 determines formation of buoyant high-density lipoprotein by macrophage foam cells. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2007 May; 27(5): 1123-31. PMID: 17303773, PII: ATVBAHA.107.139592, DOI: 10.1161/ATVBAHA.107.139592, ISSN: 1524-4636.

Yancey PG, Jerome WG, Yu H, Griffin EE, Cox BE, Babaev VR, Fazio S, Linton MF. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J. Lipid Res [print-electronic]. 2007 May; 48(5): 1140-9. PMID: 17299204, PII: M600539-JLR200, DOI: 10.1194/jlr.M600539-JLR200, ISSN: 0022-2275.

Overton CD, Yancey PG, Major AS, Linton MF, Fazio S. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ. Res [print-electronic]. 2007 Mar 3/16/2007; 100(5): 670-7. PMID: 17303763, PII: 01.RES.0000260204.40510.aa, DOI: 10.1161/01.RES.0000260204.40510.aa, ISSN: 1524-4571.

Braun NA, Mohler PJ, Weisgraber KH, Hasty AH, Linton MF, Yancey PG, Su YR, Fazio S, Swift LL. Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. J. Lipid Res [print-electronic]. 2006 Jun; 47(6): 1176-86. PMID: 16534141, PII: M500503-JLR200, DOI: 10.1194/jlr.M500503-JLR200, ISSN: 0022-2275.

Yu H, Zhang W, Yancey PG, Koury MJ, Zhang Y, Fazio S, Linton MF. Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2006 Jan; 26(1): 150-6. PMID: 16269665, PII: 01.ATV.0000194096.89476.73, DOI: 10.1161/01.ATV.0000194096.89476.73, ISSN: 1524-4636.

Burleigh ME, Babaev VR, Yancey PG, Major AS, McCaleb JL, Oates JA, Morrow JD, Fazio S, Linton MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J. Mol. Cell. Cardiol. 2005 Sep; 39(3): 443-52. PMID: 16040051, PII: S0022-2828(05)00195-1, DOI: 10.1016/j.yjmcc.2005.06.011, ISSN: 0022-2828.

Babaev VR, Yancey PG, Ryzhov SV, Kon V, Breyer MD, Magnuson MA, Fazio S, Linton MF. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Aug; 25(8): 1647-53. PMID: 15947238, PII: 01.ATV.0000173413.31789.1a, DOI: 10.1161/01.ATV.0000173413.31789.1a, ISSN: 1524-4636.

Zhang W, Yancey PG, Su YR, Babaev VR, Zhang Y, Fazio S, Linton MF. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation [print-electronic]. 2003 Nov 11/4/2003; 108(18): 2258-63. PMID: 14581413, PII: 01.CIR.0000093189.97429.9D, DOI: 10.1161/01.CIR.0000093189.97429.9D, ISSN: 1524-4539.

Jerome WG, Yancey PG. The role of microscopy in understanding atherosclerotic lysosomal lipid metabolism. Microsc. Microanal. 2003 Feb; 9(1): 54-67. PMID: 12597787, PII: S1431927603030010, DOI: 10.1017/S1431927603030010, ISSN: 1431-9276.