Lourdes Estrada, Ph.D.

Associate Professor

Faculty Appointments
Associate Professor of Biochemistry
Ph.D., Pharmacology, University of Michigan, Ann Arbor, MichiganM.S., Pharmacology, University of Michigan, Ann Arbor, MichiganB.S., Biology, University of Puerto Rico, Rio Piedras, Puerto Rico
Office Address
446 PRB
2220 Pierce Avenue
Nashville, TN 6840
Research Keywords
Mathematical modeling of cancer progression
Estrada L, Williams MA, Williams CS. A Competency-Guided Approach to Optimizing a Physician-Scientist Curriculum [editorial]. Med Sci Educ. 2022 Apr; 32(2): 523-8. PMID: 35528304, PMCID: PMC9054991, PII: 1525, DOI: 10.1007/s40670-022-01525-w, ISSN: 2156-8650.

Zivanov C, Li X, Shah KP, Estrada L, Cutrer WB, Hooks M, Keedy V, Dahlman KB. Precision Cancer Medicine: Dynamic Learning of Cancer Biology in a Clinically Meaningful Context. Med Sci Educ. 2021 Jun; 31(3): 1029-42. PMID: 34457947, PMCID: PMC8368858, PII: 1267, DOI: 10.1007/s40670-021-01267-1, ISSN: 2156-8650.

Dahlman KB, Weinger MB, Lomis KD, Nanney L, Osheroff N, Moore DE, Estrada L, Cutrer WB. Integrating Foundational Sciences in a Clinical Context in the Post-Clerkship Curriculum. Med Sci Educ [print-electronic]. 2018 Mar; 28(1): 145-54. PMID: 29632705, PMCID: PMC5889049, ISSN: 2156-8650.

Udyavar AR, Wooten DJ, Hoeksema MD, Bansal M, Califano A, Estrada L, Schnell S, Irish JM, Massion PP, Quaranta V. Novel hybrid phenotype revealed in Small Cell Lung Cancer by a transcription factor network model that can explain tumor heterogeneity. Cancer Res [print-electronic]. 2016 Dec 12/8/2016; PMID: 27932399, PII: 0008-5472.CAN-16-1467, DOI: 10.1158/0008-5472.CAN-16-1467, ISSN: 1538-7445.

Franco OE, Tyson DR, Konvinse KC, Udyavar AR, Estrada L, Quaranta V, Crawford SE, Hayward SW. Altered TGF-a/ß signaling drives cooperation between breast cancer cell populations. FASEB J [print-electronic]. 2016 Oct; 30(10): 3441-52. PMID: 27383183, PMCID: PMC5024699, PII: fj.201500187RR, DOI: 10.1096/fj.201500187RR, ISSN: 1530-6860.

Colvin DC, Jourquin J, Xu J, Does MD, Estrada L, Gore JC. Effects of intracellular organelles on the apparent diffusion coefficient of water molecules in cultured human embryonic kidney cells. Magn Reson Med [print-electronic]. 2011 Mar; 65(3): 796-801. PMID: 21337411, PMCID: PMC3285501, DOI: 10.1002/mrm.22666, ISSN: 1522-2594.

Ocak S, Yamashita H, Udyavar AR, Miller AN, Gonzalez AL, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion PP. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene [print-electronic]. 2010 Dec 12/2/2010; 29(48): 6331-42. PMID: 20802517, PMCID: PMC4637980, PII: onc2010362, DOI: 10.1038/onc.2010.362, ISSN: 1476-5594.

Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res [print-electronic]. 2009 Nov 11/15/2009; 69(22): 8797-806. PMID: 19887618, PMCID: PMC2783510, PII: 0008-5472.CAN-09-0437, DOI: 10.1158/0008-5472.CAN-09-0437, ISSN: 1538-7445.

Wang SE, Hinow P, Bryce N, Weaver AM, Estrada L, Arteaga CL, Webb GF. A mathematical model quantifies proliferation and motility effects of TGF-ß on cancer cells. Comput Math Methods Med. 2009 Mar; 10(1): 71-83. PMID: 26000030, PMCID: PMC4437567, DOI: 10.1080/17486700802171993, ISSN: 1748-6718.

Kam Y, Karperien A, Weidow B, Estrada L, Anderson AR, Quaranta V. Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements. BMC Res Notes. 2009; 2: 130. PMID: 19594934, PMCID: PMC2716356, PII: 1756-0500-2-130, DOI: 10.1186/1756-0500-2-130, ISSN: 1756-0500.

Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, Jourquin J, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence. Biophys. J [print-electronic]. 2008 Sep; 95(5): 2203-18. PMID: 18515372, PMCID: PMC2517013, PII: S0006-3495(08)78369-3, DOI: 10.1529/biophysj.108.133199, ISSN: 1542-0086.

Georgescu W, Jourquin J, Estrada L, Anderson AR, Quaranta V, Wikswo JP. Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices. Lab Chip [print-electronic]. 2008 Feb; 8(2): 238-44. PMID: 18231661, PMCID: PMC4357342, DOI: 10.1039/b716203k, ISSN: 1473-0197.

Kam Y, Guess C, Estrada L, Weidow B, Quaranta V. A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. BMC Cancer. 2008; 8: 198. PMID: 18625060, PMCID: PMC2491634, PII: 1471-2407-8-198, DOI: 10.1186/1471-2407-8-198, ISSN: 1471-2407.

Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL. Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum. Mol. Genet. 2003 Aug 8/15/2003; 12(16): 1981-93. PMID: 12913069, ISSN: 0964-6906.

Gao J, Estrada L, Cho S, Ellis RE, Gorski JL. The Caenorhabditis elegans homolog of FGD1, the human Cdc42 GEF gene responsible for faciogenital dysplasia, is critical for excretory cell morphogenesis. Hum. Mol. Genet. 2001 Dec 12/15/2001; 10(26): 3049-62. PMID: 11751687, ISSN: 0964-6906.

Estrada L, Caron E, Gorski JL. Fgd1, the Cdc42 guanine nucleotide exchange factor responsible for faciogenital dysplasia, is localized to the subcortical actin cytoskeleton and Golgi membrane. Hum. Mol. Genet. 2001 Mar 3/1/2001; 10(5): 485-95. PMID: 11181572, ISSN: 0964-6906.

Gorski JL, Estrada L, Hu C, Liu Z. Skeletal-specific expression of Fgd1 during bone formation and skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome). Dev. Dyn. 2000 Aug; 218(4): 573-86. PMID: 10906777, PII: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1015>3.0.CO;2-F, DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1015>3.0.CO;2-F, ISSN: 1058-8388.

Morishima Y, Kanelakis KC, Silverstein AM, Dittmar KD, Estrada L, Pratt WB. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. J. Biol. Chem. 2000 Mar 3/10/2000; 275(10): 6894-900. PMID: 10702249, ISSN: 0021-9258.

Estrada L, Kanelakis KC, Levy GN, Weber WW. Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1. Drug Metab. Dispos. 2000 Feb; 28(2): 139-46. PMID: 10640510, ISSN: 0090-9556.

García-Arrarás JE, Estrada-Rodgers L, Santiago R, Torres II, Díaz-Miranda L, Torres-Avillán I. Cellular mechanisms of intestine regeneration in the sea cucumber, Holothuria glaberrima Selenka (Holothuroidea:Echinodermata). J. Exp. Zool. 1998 Jul 7/1/1998; 281(4): 288-304. PMID: 9658592, PII: 10.1002/(SICI)1097-010X(19980701)281:4<288::AID-JEZ5>3.0.CO;2-K, ISSN: 0022-104X.

Estrada-Rodgers L, Levy GN, Weber WW. Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells. Drug Metab. Dispos. 1998 May; 26(5): 502-5. PMID: 9571233, ISSN: 0090-9556.

Estrada-Rodgers L, Levy GN, Weber WW. Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter. Gene Expr. 1998; 7(1): 13-24. PMID: 9572394, ISSN: 1052-2166.

Levy GN, Rodgers L, Weber WW. Effects of heredity on response to drugs and environmental chemicals: construction of rodent models. Chem. Res. Toxicol. 1996 Dec; 9(8): 1215-24. PMID: 8951222, PII: tx960082y, DOI: 10.1021/tx960082y, ISSN: 0893-228X.