James M. Luther, M.D.

Associate Professor

Faculty Appointments
Associate Professor of Medicine Associate Professor of Pharmacology
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., Medicine, Vanderbilt University, Nashville, TennesseeB.S., Biochemistry, David Lipscomb University, Nashville, Tennessee
Office Address
560C RRB
2200 Pierce Ave.
Nashville, TN 37232-6602
Research Description
Dr. Luther's research focuses on the roler of the renin-angiotensin-aldosterone system on glucose regulation using human and animal models. We are using pharmacologic tools and genetic interruption to investigate the effects on insulin secretion and insulin sensitivity in vivo.
Clinical Description
Dr. Luther is director of the Vanderbilt AHA Comprehensive Hypertension Center, where he evaluates and treats resistant and secondary causes of hypertension such as primary aldosteronism and renovascular hypertension. He is board certified in Internal Medicine, and Nephrology. He also certified as a Hypertension Specialist.
Research Keywords
insulin resistance aldosterone insulin secretion metabolic syndrome
Clinical Research Keywords
Hypertension Primary Aldosteronism Kidney disease Diabetes Insulin resistance
Mashayekhi M, Nian H, Mayfield D, Devin JK, Gamboa JL, Yu C, Silver HJ, Niswender K, Luther JM, Brown NJ. Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals with Obesity and Pre-Diabetes. Diabetes [print-electronic]. 2023 Oct 10/24/2023; PMID: 37874653, PII: 153785, DOI: 10.2337/db23-0356, ISSN: 1939-327X.

Luther JM, Turcu AF. Unilaterally Successful Adrenal Vein Sampling: Use or Repeat? [editorial]. Hypertension [print-electronic]. 2023 Oct; 80(10): 2014-6. PMID: 37729635, DOI: 10.1161/HYPERTENSIONAHA.123.21563, ISSN: 1524-4563.

Laffin LJ, Rodman D, Luther JM, Vaidya A, Weir MR, Rajicic N, Slingsby BT, Nissen SE, . Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial. JAMA. 2023 Sep 9/26/2023; 330(12): 1140-50. PMID: 37690061, PMCID: PMC10493865, PII: 2809625, DOI: 10.1001/jama.2023.16029, ISSN: 1538-3598.

Silver HJ, Olson D, Mayfield D, Wright P, Nian H, Mashayekhi M, Koethe JR, Niswender KD, Luther JM, Brown NJ. Effect of the glucagon-like peptide-1 receptor agonist liraglutide, compared to caloric restriction, on appetite, dietary intake, body fat distribution and cardiometabolic biomarkers: A randomized trial in adults with obesity and prediabetes. Diabetes Obes Metab [print-electronic]. 2023 May 5/15/2023; PMID: 37188932, DOI: 10.1111/dom.15113, ISSN: 1463-1326.

Foer D, Beeler PE, Cui J, Snyder WE, Mashayekhi M, Nian H, Luther JM, Karlson EW, Boyce JA, Cahill KN. Glucagon-like peptide-1 receptor agonist use is associated with lower serum periostin [letter]. Clin Exp Allergy [print-electronic]. 2023 Apr; 53(4): 469-73. PMID: 36648098, PMCID: PMC10106378, DOI: 10.1111/cea.14284, ISSN: 1365-2222.

Mashayekhi M, Beckman JA, Nian H, Garner EM, Mayfield D, Devin JK, Koethe JR, Brown JD, Cahill KN, Yu C, Silver H, Niswender K, Luther JM, Brown NJ. Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis and inflammation in individuals with obesity and prediabetes: A randomized controlled trial. Diabetes Obes Metab [print-electronic]. 2023 Feb; 25(2): 570-80. PMID: 36306151, DOI: 10.1111/dom.14903, ISSN: 1463-1326.

Mashayekhi M, Beckman JA, Nian H, Garner EM, Mayfield D, Devin JK, Koethe JR, Brown JD, Cahill KN, Yu C, Silver H, Niswender K, Luther JM, Brown NJ. Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis and inflammation in individuals with obesity and prediabetes: A randomized controlled trial. Diabetes Obes Metab [print-electronic]. 2022 Oct 10/28/2022; PMID: 36306151, DOI: 10.1111/dom.14903, ISSN: 1463-1326.

Bhalla V, Textor SC, Beckman JA, Casanegra AI, Cooper CJ, Kim ESH, Luther JM, Misra S, Oderich GS, . Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association. Hypertension [print-electronic]. 2022 Aug; 79(8): e128-e143-e143. PMID: 35708012, DOI: 10.1161/HYP.0000000000000217, ISSN: 1524-4563.

Cahill KN, Amin T, Boutaud O, Printz R, Newcomb DC, Foer D, Hodson DJ, Broichhagen J, Beckman JA, Yu C, Nian H, Mashayekhi M, Silver HJ, Luther JM, Brown NJ, Peebles RS, Niswender K. Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation. JACC Basic Transl Sci. 2022 Jul; 7(7): 713-5. PMID: 35958685, PMCID: PMC9357570, PII: S2452-302X(22)00141-3, DOI: 10.1016/j.jacbts.2022.04.004, ISSN: 2452-302X.

Brown JM, Auchus RJ, Honzel B, Luther JM, Yozamp N, Vaidya A. Recalibrating Interpretations of Aldosterone Assays Across the Physiologic Range: Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry Measurements Under Multiple Controlled Conditions. J Endocr Soc. 2022 Jun 6/1/2022; 6(6): bvac049. PMID: 35475027, PMCID: PMC9032635, PII: bvac049, DOI: 10.1210/jendso/bvac049, ISSN: 2472-1972.

Parksook WW, Heydarpour M, Gholami SK, Luther JM, Hopkins PN, Pojoga LH, Williams JS. Salt Sensitivity of Blood Pressure and Aldosterone: Interaction Between the Lysine-specific Demethylase 1 Gene, Sex, and Age. J Clin Endocrinol Metab. 2022 Apr 4/19/2022; 107(5): 1294-302. PMID: 35022775, PMCID: PMC9016472, PII: 6503734, DOI: 10.1210/clinem/dgac011, ISSN: 1945-7197.

Sahinoz M, Luther JM, Mashayekhi M, Jung DK, Ikizler TA, Engelhardt BG. Hematologic malignancies magnify the effect of body mass index on insulin resistance in cancer survivors. Blood Adv. 2022 Apr 4/12/2022; 6(7): 1981-90. PMID: 35130338, PMCID: PMC9006273, PII: 483855, DOI: 10.1182/bloodadvances.2021006241, ISSN: 2473-9537.

Luther JM, Fogo AB. The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis. Kidney Int Suppl (2011) [print-electronic]. 2022 Apr; 12(1): 63-8. PMID: 35529087, PMCID: PMC9073221, PII: S2157-1716(21)00069-1, DOI: 10.1016/j.kisu.2021.11.006, ISSN: 2157-1724.

Mashayekhi M, Wanjalla CN, Warren CM, Simmons JD, Ghoshal K, Pilkinton M, Bailin SS, Gabriel CL, Pozzi A, Koethe JR, Brown NJ, Kalams SA, Luther JM. The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells. Prostaglandins Other Lipid Mediat [print-electronic]. 2022 Feb; 158: 106604. PMID: 34922004, PMCID: PMC8742790, PII: S1098-8823(21)00079-4, DOI: 10.1016/j.prostaglandins.2021.106604, ISSN: 1098-8823.

Rege J, Hoxie J, Liu CJ, Cash MN, Luther JM, Gellert L, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K. Targeted Mutational Analysis of Cortisol-Producing Adenomas. J Clin Endocrinol Metab. 2022 Jan 1/18/2022; 107(2): e594-e603. PMID: 34534321, PMCID: PMC8764218, PII: 6371838, DOI: 10.1210/clinem/dgab682, ISSN: 1945-7197.

Ghoshal K, Li X, Peng D, Falck JR, Anugu RR, Chiusa M, Stafford JM, Wasserman DH, Zent R, Luther JM, Pozzi A. EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance. Diabetes [print-electronic]. 2021 Oct 10/21/2021; PMID: 34675004, PII: db21-0298, DOI: 10.2337/db21-0298, ISSN: 1939-327X.

Ghoshal K, Li X, Peng D, Falck JR, Anugu RR, Chiusa M, Stafford JM, Wasserman DH, Zent R, Luther JM, Pozzi A. EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance. Diabetes [print-electronic]. 2021 Oct 10/21/2021; PMID: 34957494, PII: 139089, DOI: 10.2337/db21-0298, ISSN: 1939-327X.

Luther JM, Ray J, Wei D, Koethe JR, Hannah L, DeMatteo A, Manning R, Terker AS, Peng D, Nian H, Yu C, Mashayekhi M, Gamboa J, Brown NJ. GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans. Hypertension [print-electronic]. 2021 Sep; 78(4): 1092-102. PMID: 34455816, PMCID: PMC8429121, DOI: 10.1161/HYPERTENSIONAHA.121.17659, ISSN: 1524-4563.

Akwo EA, Robinson-Cohen C, Chung CP, Shah SC, Brown NJ, Ikizler TA, Wilson OD, Rowan BX, Shuey MM, Siew ED, Luther JM, Giri A, Hellwege JN, Velez Edwards DR, Roumie CL, Tao R, Tsao PS, Gaziano JM, Wilson PWF, O'Donnell CJ, Edwards TL, Kovesdy CP, Hung AM, . Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program. Hypertension [print-electronic]. 2021 Aug; 78(2): 376-86. PMID: 34148359, PMCID: PMC8364328, DOI: 10.1161/HYPERTENSIONAHA.120.16181, ISSN: 1524-4563.

Lee T, Cau A, Cheng MP, Levin A, Lee TC, Vinh DC, Lamontagne F, Singer J, Walley KR, Murthy S, Patrick D, Rewa OG, Winston BW, Marshall J, Boyd J, Tran K, Kalil AC, Mcculoh R, Fowler R, Luther JM, Russell JA, . Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in COVID-19: Meta-analysis/Meta-regression Adjusted for Confounding Factors. CJC Open [print-electronic]. 2021 Jul; 3(7): 965-75. PMID: 33842874, PMCID: PMC8023793, PII: S2589-790X(21)00071-8, DOI: 10.1016/j.cjco.2021.03.001, ISSN: 2589-790X.

Erdbrügger U, Blijdorp CJ, Bijnsdorp IV, Borràs FE, Burger D, Bussolati B, Byrd JB, Clayton A, Dear JW, Falcón-Pérez JM, Grange C, Hill AF, Holthöfer H, Hoorn EJ, Jenster G, Jimenez CR, Junker K, Klein J, Knepper MA, Koritzinsky EH, Luther JM, Lenassi M, Leivo J, Mertens I, Musante L, Oeyen E, Puhka M, van Royen ME, Sánchez C, Soekmadji C, Thongboonkerd V, van Steijn V, Verhaegh G, Webber JP, Witwer K, Yuen PST, Zheng L, Llorente A, Martens-Uzunova ES. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles [print-electronic]. 2021 May; 10(7): e12093. PMID: 34035881, PMCID: PMC8138533, PII: JEV212093, DOI: 10.1002/jev2.12093.

Luther JM, Wei DS, Ghoshal K, Peng D, Adler GK, Turcu AF, Nian H, Yu C, Solorzano CC, Pozzi A, Brown NJ. Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids. Hypertension [print-electronic]. 2021 Apr; 77(4): 1323-31. PMID: 33583202, PMCID: PMC8320355, DOI: 10.1161/HYPERTENSIONAHA.120.14808, ISSN: 1524-4563.

Gregory JM, Slaughter JC, Duffus SH, Smith TJ, LeStourgeon LM, Jaser SS, McCoy AB, Luther JM, Giovannetti ER, Boeder S, Pettus JH, Moore DJ. COVID-19 Severity Is Tripled in the Diabetes Community: A Prospective Analysis of the Pandemic's Impact in Type 1 and Type 2 Diabetes. Diabetes Care [print-electronic]. 2020 Dec 12/2/2020; PMID: 33268335, PII: dc20-2260, DOI: 10.2337/dc20-2260, ISSN: 1935-5548.

Mashayekhi M, Wilson JR, Jafarian-Kerman S, Nian H, Yu C, Shuey MM, Luther JM, Brown NJ. Association of a glucagon-like peptide-1 receptor gene variant with glucose response to a mixed meal. Diabetes Obes Metab [print-electronic]. 2020 Oct 10/1/2020; PMID: 33001556, DOI: 10.1111/dom.14216, ISSN: 1463-1326.

Prinsen JK, Kannankeril PJ, Sidorova TN, Yermalitskaya LV, Boutaud O, Zagol-Ikapitte I, Barnett JV, Murphy MB, Subati T, Stark JM, Christopher IL, Jafarian-Kerman SR, Saleh MA, Norlander AE, Loperena R, Atkinson JB, Fogo AB, Luther JM, Amarnath V, Davies SS, Kirabo A, Madhur MS, Harrison DG, Murray KT. Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension. JACC Basic Transl Sci. 2020 Jun; 5(6): 602-15. PMID: 32613146, PMCID: PMC7315188, PII: S2452-302X(20)30165-0, DOI: 10.1016/j.jacbts.2020.04.004, ISSN: 2452-302X.

Shuey M, Perkins B, Nian H, Yu C, Luther JM, Brown N. Retrospective cohort study to characterise the blood pressure response to spironolactone in patients with apparent therapy-resistant hypertension using electronic medical record data. BMJ Open. 2020 May 5/26/2020; 10(5): e033100. PMID: 32461291, PMCID: PMC7259833, PII: bmjopen-2019-033100, DOI: 10.1136/bmjopen-2019-033100, ISSN: 2044-6055.

Sparks MA, South A, Welling P, Luther JM, Cohen J, Byrd JB, Burrell LM, Batlle D, Tomlinson L, Bhalla V, Rheault MN, Soler MJ, Swaminathan S, Hiremath S. Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19. Clin J Am Soc Nephrol [print-electronic]. 2020 May 5/7/2020; 15(5): 714-6. PMID: 32220930, PMCID: PMC7269218, PII: CJN.03530320, DOI: 10.2215/CJN.03530320, ISSN: 1555-905X.

Adler GK, Murray GR, Turcu AF, Nian H, Yu C, Solorzano CC, Manning R, Peng D, Luther JM. Primary Aldosteronism Decreases Insulin Secretion and Increases Insulin Clearance in Humans. Hypertension [print-electronic]. 2020 May; 75(5): 1251-9. PMID: 32172621, PMCID: PMC7155918, DOI: 10.1161/HYPERTENSIONAHA.119.13922, ISSN: 1524-4563.

Dixon DL, Salgado TM, Luther JM, Byrd JB. Medicare reimbursement policy for ambulatory blood pressure monitoring: A qualitative analysis of public comments to the Centers for Medicare and Medicaid Services. J Clin Hypertens (Greenwich) [print-electronic]. 2019 Dec; 21(12): 1803-9. PMID: 31642596, DOI: 10.1111/jch.13719, ISSN: 1751-7176.

Luther JM, Dominiczak AF, Jennings GLR, VanDevender FK, Carey RM, Peixoto AJ, Chung CP, Oates JA. Paroxysmal Hypertension Associated With Presyncope. Hypertension [print-electronic]. 2019 Oct; 74(4): 718-25. PMID: 31476903, DOI: 10.1161/HYPERTENSIONAHA.119.13341, ISSN: 1524-4563.

Luther JM, Fogo AB. Under pressure-how to assess blood pressure in rodents: tail-cuff?. Kidney Int. 2019 Jul; 96(1): 34-6. PMID: 31229047, PII: S0085-2538(19)30153-X, DOI: 10.1016/j.kint.2018.12.034, ISSN: 1523-1755.

Nanba K, Omata K, Gomez-Sanchez CE, Stratakis CA, Demidowich AP, Suzuki M, Thompson LDR, Cohen DL, Luther JM, Gellert L, Vaidya A, Barletta JA, Else T, Giordano TJ, Tomlins SA, Rainey WE. Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks. Hypertension. 2019 Apr; 73(4): 885-92. PMID: 30739536, PMCID: PMC6416065, DOI: 10.1161/HYPERTENSIONAHA.118.12070, ISSN: 1524-4563.

Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP. Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study. Clin. Pharmacol. Ther [print-electronic]. 2019 Mar; 105(3): 703-9. PMID: 30223305, PMCID: PMC6379114, DOI: 10.1002/cpt.1233, ISSN: 1532-6535.

Gunasekaran PM, Luther JM, Byrd JB. For what factors should we normalize urinary extracellular mRNA biomarkers?. Biomol Detect Quantif. 2019 Mar; 17: 100090. PMID: 31285998, PMCID: PMC6591792, PII: 100090, PII: S2214-7535(18)30027-5, DOI: 10.1016/j.bdq.2019.100090, ISSN: 2214-7535.

Collins SP, Jenkins CA, Baughman A, Miller KF, Storrow AB, Han JH, Brown NJ, Liu D, Luther JM, McNaughton CD, Self WH, Peng D, Testani JM, Lindenfeld J. Early urine electrolyte patterns in patients with acute heart failure. ESC Heart Fail [print-electronic]. 2019 Feb; 6(1): 80-8. PMID: 30295437, PMCID: PMC6351901, DOI: 10.1002/ehf2.12368, ISSN: 2055-5822.

Hemnes AR, Luther JM, Rhodes CJ, Burgess JP, Carlson J, Fan R, Fessel JP, Fortune N, Gerszten RE, Halliday SJ, Hekmat R, Howard L, Newman JH, Niswender KD, Pugh ME, Robbins IM, Sheng Q, Shibao CA, Shyr Y, Sumner S, Talati M, Wharton J, Wilkins MR, Ye F, Yu C, West J, Brittain EL. Human PAH is characterized by a pattern of lipid-related insulin resistance. JCI Insight [print-electronic]. 2019 Jan 1/10/2019; 4(1): PMID: 30626738, PMCID: PMC6485674, PII: 123611, DOI: 10.1172/jci.insight.123611, ISSN: 2379-3708.

Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production. Cancer Res [print-electronic]. 2018 Sep 9/1/2018; 78(17): 4865-77. PMID: 30012669, PMCID: PMC6125168, PII: 0008-5472.CAN-17-3977, DOI: 10.1158/0008-5472.CAN-17-3977, ISSN: 1538-7445.

Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM. Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. Diabetologia [print-electronic]. 2017 Jun; 60(6): 1066-75. PMID: 28352940, PII: 10.1007/s00125-017-4260-0, DOI: 10.1007/s00125-017-4260-0, ISSN: 1432-0428.

Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA. Hyperinsulinemia and Insulin Resistance in Dopamine ß-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab. 2017 Jan 1/1/2017; 102(1): 10-4. PMID: 27778639, PMCID: PMC5413093, DOI: 10.1210/jc.2016-3274, ISSN: 1945-7197.

Luther JM, Brown NJ. Epoxyeicosatrienoic acids and glucose homeostasis in mice and men. Prostaglandins Other Lipid Mediat [print-electronic]. 2016 Sep; 125: 2-7. PMID: 27448715, PMCID: PMC5035218, PII: S1098-8823(16)30041-7, DOI: 10.1016/j.prostaglandins.2016.07.010, ISSN: 1098-8823.

Shah SS, Ramirez CE, Powers AC, Yu C, Shibao CA, Luther JM. Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects. Metab. Clin. Exp [print-electronic]. 2016 Jun; 65(6): 835-42. PMID: 27173462, PMCID: PMC4867079, PII: S0026-0495(16)00050-0, DOI: 10.1016/j.metabol.2016.02.011, ISSN: 1532-8600.

Qi Y, Wang X, Rose KL, MacDonald WH, Zhang B, Schey KL, Luther JM. Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion. J. Am. Soc. Nephrol [print-electronic]. 2016 Feb; 27(2): 646-56. PMID: 26113616, PMCID: PMC4731116, PII: ASN.2014111137, DOI: 10.1681/ASN.2014111137, ISSN: 1533-3450.

Luther JM. Aldosterone in vascular and metabolic dysfunction. Curr. Opin. Nephrol. Hypertens. 2016 Jan; 25(1): 16-21. PMID: 26575396, PMCID: PMC4824306, DOI: 10.1097/MNH.0000000000000189, ISSN: 1473-6543.

Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. J. Clin. Endocrinol. Metab [print-electronic]. 2015 Dec; 100(12): 4533-40. PMID: 26580240, PMCID: PMC4667163, DOI: 10.1210/jc.2015-3415, ISSN: 1945-7197.

Schey KL, Luther JM, Rose KL. Proteomics characterization of exosome cargo. Methods [print-electronic]. 2015 Oct 10/1/2015; 87: 75-82. PMID: 25837312, PMCID: PMC4591097, PII: S1046-2023(15)00124-3, DOI: 10.1016/j.ymeth.2015.03.018, ISSN: 1046-2023.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J. Am. Soc. Nephrol [print-electronic]. 2015 Mar; 26(3): 597-610. PMID: 25071086, PMCID: PMC4341468, PII: ASN.2013090980, DOI: 10.1681/ASN.2013090980, ISSN: 1533-3450.

Luther JM. Effects of aldosterone on insulin sensitivity and secretion. Steroids [print-electronic]. 2014 Dec; 91: 54-60. PMID: 25194457, PMCID: PMC4252580, PII: S0039-128X(14)00213-X, DOI: 10.1016/j.steroids.2014.08.016, ISSN: 1878-5867.

Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ. Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans. J. Clin. Endocrinol. Metab [print-electronic]. 2014 Oct; 99(10): E1895-902. PMID: 25029426, PMCID: PMC4184066, DOI: 10.1210/jc.2014-2122, ISSN: 1945-7197.

Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown NJ. Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins Other Lipid Mediat [print-electronic]. 2014 Oct; 113-115: 38-44. PMID: 25173047, PMCID: PMC4253976, PII: S1098-8823(14)00032-X, DOI: 10.1016/j.prostaglandins.2014.08.001, ISSN: 1098-8823.

Luther JM. Is there a new dawn for selective mineralocorticoid receptor antagonism?. Curr. Opin. Nephrol. Hypertens. 2014 Sep; 23(5): 456-61. PMID: 24992570, PMCID: PMC4248353, DOI: 10.1097/MNH.0000000000000051, ISSN: 1473-6543.

Gilbert K, Nian H, Yu C, Luther JM, Brown NJ. Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension. J. Hypertens. 2013 Apr; 31(4): 820-9. PMID: 23385647, PMCID: PMC3800119, DOI: 10.1097/HJH.0b013e32835e8227, ISSN: 1473-5598.

Luo P, Dematteo A, Wang Z, Zhu L, Wang A, Kim HS, Pozzi A, Stafford JM, Luther JM. Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice. Diabetologia [print-electronic]. 2013 Apr; 56(4): 901-10. PMID: 23314847, PMCID: PMC3593801, DOI: 10.1007/s00125-012-2814-8, ISSN: 1432-0428.

Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ. Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Kidney Int [print-electronic]. 2012 Sep; 82(6): 643-51. PMID: 22622494, PMCID: PMC3434275, PII: ki2012170, DOI: 10.1038/ki.2012.170, ISSN: 1523-1755.

Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 334-42. PMID: 22158433, PMCID: PMC3269170, PII: ASN.2011030287, DOI: 10.1681/ASN.2011030287, ISSN: 1533-3450.

Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Proteomics [print-electronic]. 2012 Jan; 12(2): 329-38. PMID: 22106071, PMCID: PMC3517144, DOI: 10.1002/pmic.201100477, ISSN: 1615-9861.

Luther JM, Brown NJ. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol. Sci [print-electronic]. 2011 Dec; 32(12): 734-9. PMID: 21880378, PMCID: PMC3223326, PII: S0165-6147(11)00138-6, DOI: 10.1016/j.tips.2011.07.006, ISSN: 1873-3735.

Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia [print-electronic]. 2011 Aug; 54(8): 2152-63. PMID: 21519965, PMCID: PMC3216479, DOI: 10.1007/s00125-011-2158-9, ISSN: 1432-0428.

Smith JP, Weller S, Johnson B, Nicotera J, Luther JM, Haas DW. Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob. Agents Chemother [print-electronic]. 2010 Mar; 54(3): 1146-51. PMID: 20038622, PMCID: PMC2825963, PII: AAC.00729-09, DOI: 10.1128/AAC.00729-09, ISSN: 1098-6596.

Marney AM, Ma J, Luther JM, Ikizler TA, Brown NJ. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2009 Oct; 20(10): 2246-52. PMID: 19628666, PMCID: PMC2754101, PII: ASN.2009050505, DOI: 10.1681/ASN.2009050505, ISSN: 1533-3450.

Luther JM, Wang Z, Ma J, Makhanova N, Kim HS, Brown NJ. Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta. Endocrinology [print-electronic]. 2009 May; 150(5): 2229-36. PMID: 19106220, PMCID: PMC2671907, PII: en.2008-1296, DOI: 10.1210/en.2008-1296, ISSN: 1945-7170.

Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int [print-electronic]. 2009 May; 75(9): 936-44. PMID: 19225557, PMCID: PMC2770712, PII: ki20099, DOI: 10.1038/ki.2009.9, ISSN: 1523-1755.

Pretorius M, van Guilder GP, Guzman RJ, Luther JM, Brown NJ. 17Beta-estradiol increases basal but not bradykinin-stimulated release of active t-PA in young postmenopausal women. Hypertension [print-electronic]. 2008 Apr; 51(4): 1190-6. PMID: 18259028, PMCID: PMC2673569, PII: HYPERTENSIONAHA.107.105627, DOI: 10.1161/HYPERTENSIONAHA.107.105627, ISSN: 1524-4563.

Luther JM, Golper TA. Blood pressure targets in hemodialysis patients. Kidney Int. 2008 Mar; 73(6): 667-8. PMID: 18309346, PII: 5002799, DOI: 10.1038/sj.ki.5002799, ISSN: 1523-1755.

Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown NJ. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2008 Feb; 51(2): 454-9. PMID: 18180402, PMCID: PMC2581632, PII: HYPERTENSIONAHA.107.102574, DOI: 10.1161/HYPERTENSIONAHA.107.102574, ISSN: 1524-4563.

Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin. Pharmacol. Ther [print-electronic]. 2008 Jan; 83(1): 122-9. PMID: 17522594, PII: 6100250, DOI: 10.1038/sj.clpt.6100250, ISSN: 1532-6535.

Luther JM, Gainer JV, Murphey LJ, Yu C, Vaughan DE, Morrow JD, Brown NJ. Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism. Hypertension [print-electronic]. 2006 Dec; 48(6): 1050-7. PMID: 17043157, PII: 01.HYP.0000248135.97380.76, DOI: 10.1161/01.HYP.0000248135.97380.76, ISSN: 1524-4563.

Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Sep; 318(3): 1287-92. PMID: 16772538, PII: jpet.106.104026, DOI: 10.1124/jpet.106.104026, ISSN: 0022-3565.

Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Nov; 25(11): 2435-40. PMID: 16166566, PII: 01.ATV.0000186185.13977.94, DOI: 10.1161/01.ATV.0000186185.13977.94, ISSN: 1524-4636.

Luther JM, Lakey DL, Larson RS, Kallianpur AR, D'Agata E, Cousar JB, Haas DW. Utility of bone marrow biopsy for rapid diagnosis of febrile illnesses in patients with human immunodeficiency virus infection. South. Med. J. 2000 Jul; 93(7): 692-7. PMID: 10923958, ISSN: 0038-4348.

Spector JE, Werkhaven JA, Spector NC, Huang S, Page RN, Baranowski B, Luther M, McGehee B, Reinisch L. Preservation of function and histologic appearance in the injured glottis with topical mitomycin-C. Laryngoscope. 1999 Jul; 109(7 Pt 1): 1125-9. PMID: 10401854, ISSN: 0023-852X.