James M. Luther, M.D.

Associate Professor

Faculty Appointments
Associate Professor of Medicine Associate Professor of Pharmacology
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., Medicine, Vanderbilt University, Nashville, TennesseeB.S., Biochemistry, David Lipscomb University, Nashville, Tennessee
Office Address
560C RRB
2200 Pierce Ave.
Nashville, TN 37232-6602
Research Keywords
Dr. Luther's research focuses on the roler of the renin-angiotensin-aldosterone system on glucose regulation using human and animal models. We are using pharmacologic tools and genetic interruption to investigate the effects on insulin secretion and insulin sensitivity in vivo.
Clinical Research Keywords
Hypertension Kidney disease Diabetes Insulin resistance
Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM. Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. Diabetologia [print-electronic]. 2017 Jun; 60(6): 1066-75. PMID: 28352940, PII: 10.1007/s00125-017-4260-0, DOI: 10.1007/s00125-017-4260-0, ISSN: 1432-0428.

Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA. Hyperinsulinemia and Insulin Resistance in Dopamine ß-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab. 2017 Jan 1/1/2017; 102(1): 10-4. PMID: 27778639, PMCID: PMC5413093, DOI: 10.1210/jc.2016-3274, ISSN: 1945-7197.

Luther JM, Brown NJ. Epoxyeicosatrienoic acids and glucose homeostasis in mice and men. Prostaglandins Other Lipid Mediat [print-electronic]. 2016 Sep; 125: 2-7. PMID: 27448715, PMCID: PMC5035218, PII: S1098-8823(16)30041-7, DOI: 10.1016/j.prostaglandins.2016.07.010, ISSN: 1098-8823.

Shah SS, Ramirez CE, Powers AC, Yu C, Shibao CA, Luther JM. Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects. Metab. Clin. Exp [print-electronic]. 2016 Jun; 65(6): 835-42. PMID: 27173462, PMCID: PMC4867079, PII: S0026-0495(16)00050-0, DOI: 10.1016/j.metabol.2016.02.011, ISSN: 1532-8600.

Qi Y, Wang X, Rose KL, MacDonald WH, Zhang B, Schey KL, Luther JM. Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion. J. Am. Soc. Nephrol [print-electronic]. 2016 Feb; 27(2): 646-56. PMID: 26113616, PMCID: PMC4731116, PII: ASN.2014111137, DOI: 10.1681/ASN.2014111137, ISSN: 1533-3450.

Luther JM. Aldosterone in vascular and metabolic dysfunction. Curr. Opin. Nephrol. Hypertens. 2016 Jan; 25(1): 16-21. PMID: 26575396, PMCID: PMC4824306, DOI: 10.1097/MNH.0000000000000189, ISSN: 1473-6543.

Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. J. Clin. Endocrinol. Metab [print-electronic]. 2015 Dec; 100(12): 4533-40. PMID: 26580240, PMCID: PMC4667163, DOI: 10.1210/jc.2015-3415, ISSN: 1945-7197.

Schey KL, Luther JM, Rose KL. Proteomics characterization of exosome cargo. Methods [print-electronic]. 2015 Oct 10/1/2015; 87: 75-82. PMID: 25837312, PMCID: PMC4591097, PII: S1046-2023(15)00124-3, DOI: 10.1016/j.ymeth.2015.03.018, ISSN: 1046-2023.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J. Am. Soc. Nephrol [print-electronic]. 2015 Mar; 26(3): 597-610. PMID: 25071086, PMCID: PMC4341468, PII: ASN.2013090980, DOI: 10.1681/ASN.2013090980, ISSN: 1533-3450.

Luther JM. Effects of aldosterone on insulin sensitivity and secretion. Steroids [print-electronic]. 2014 Dec; 91: 54-60. PMID: 25194457, PMCID: PMC4252580, PII: S0039-128X(14)00213-X, DOI: 10.1016/j.steroids.2014.08.016, ISSN: 1878-5867.

Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ. Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans. J. Clin. Endocrinol. Metab [print-electronic]. 2014 Oct; 99(10): E1895-902. PMID: 25029426, PMCID: PMC4184066, DOI: 10.1210/jc.2014-2122, ISSN: 1945-7197.

Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown NJ. Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins Other Lipid Mediat [print-electronic]. 2014 Oct; 113-115: 38-44. PMID: 25173047, PMCID: PMC4253976, PII: S1098-8823(14)00032-X, DOI: 10.1016/j.prostaglandins.2014.08.001, ISSN: 1098-8823.

Luther JM. Is there a new dawn for selective mineralocorticoid receptor antagonism?. Curr. Opin. Nephrol. Hypertens. 2014 Sep; 23(5): 456-61. PMID: 24992570, PMCID: PMC4248353, DOI: 10.1097/MNH.0000000000000051, ISSN: 1473-6543.

Gilbert K, Nian H, Yu C, Luther JM, Brown NJ. Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension. J. Hypertens. 2013 Apr; 31(4): 820-9. PMID: 23385647, PMCID: PMC3800119, DOI: 10.1097/HJH.0b013e32835e8227, ISSN: 1473-5598.

Luo P, Dematteo A, Wang Z, Zhu L, Wang A, Kim HS, Pozzi A, Stafford JM, Luther JM. Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice. Diabetologia [print-electronic]. 2013 Apr; 56(4): 901-10. PMID: 23314847, PMCID: PMC3593801, DOI: 10.1007/s00125-012-2814-8, ISSN: 1432-0428.

Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ. Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury. Kidney Int [print-electronic]. 2012 Sep; 82(6): 643-51. PMID: 22622494, PMCID: PMC3434275, PII: ki2012170, DOI: 10.1038/ki.2012.170, ISSN: 1523-1755.

Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 334-42. PMID: 22158433, PMCID: PMC3269170, PII: ASN.2011030287, DOI: 10.1681/ASN.2011030287, ISSN: 1533-3450.

Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT). Proteomics [print-electronic]. 2012 Jan; 12(2): 329-38. PMID: 22106071, PMCID: PMC3517144, DOI: 10.1002/pmic.201100477, ISSN: 1615-9861.

Luther JM, Brown NJ. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends Pharmacol. Sci [print-electronic]. 2011 Dec; 32(12): 734-9. PMID: 21880378, PMCID: PMC3223326, PII: S0165-6147(11)00138-6, DOI: 10.1016/j.tips.2011.07.006, ISSN: 1873-3735.

Luther JM, Luo P, Kreger MT, Brissova M, Dai C, Whitfield TT, Kim HS, Wasserman DH, Powers AC, Brown NJ. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia [print-electronic]. 2011 Aug; 54(8): 2152-63. PMID: 21519965, PMCID: PMC3216479, DOI: 10.1007/s00125-011-2158-9, ISSN: 1432-0428.

Smith JP, Weller S, Johnson B, Nicotera J, Luther JM, Haas DW. Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob. Agents Chemother [print-electronic]. 2010 Mar; 54(3): 1146-51. PMID: 20038622, PMCID: PMC2825963, PII: AAC.00729-09, DOI: 10.1128/AAC.00729-09, ISSN: 1098-6596.

Marney AM, Ma J, Luther JM, Ikizler TA, Brown NJ. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2009 Oct; 20(10): 2246-52. PMID: 19628666, PMCID: PMC2754101, PII: ASN.2009050505, DOI: 10.1681/ASN.2009050505, ISSN: 1533-3450.

Luther JM, Wang Z, Ma J, Makhanova N, Kim HS, Brown NJ. Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta. Endocrinology [print-electronic]. 2009 May; 150(5): 2229-36. PMID: 19106220, PMCID: PMC2671907, PII: en.2008-1296, DOI: 10.1210/en.2008-1296, ISSN: 1945-7170.

Lea WB, Kwak ES, Luther JM, Fowler SM, Wang Z, Ma J, Fogo AB, Brown NJ. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int [print-electronic]. 2009 May; 75(9): 936-44. PMID: 19225557, PMCID: PMC2770712, PII: ki20099, DOI: 10.1038/ki.2009.9, ISSN: 1523-1755.

Pretorius M, van Guilder GP, Guzman RJ, Luther JM, Brown NJ. 17Beta-estradiol increases basal but not bradykinin-stimulated release of active t-PA in young postmenopausal women. Hypertension [print-electronic]. 2008 Apr; 51(4): 1190-6. PMID: 18259028, PMCID: PMC2673569, PII: HYPERTENSIONAHA.107.105627, DOI: 10.1161/HYPERTENSIONAHA.107.105627, ISSN: 1524-4563.

Luther JM, Golper TA. Blood pressure targets in hemodialysis patients. Kidney Int. 2008 Mar; 73(6): 667-8. PMID: 18309346, PII: 5002799, DOI: 10.1038/sj.ki.5002799, ISSN: 1523-1755.

Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown NJ. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2008 Feb; 51(2): 454-9. PMID: 18180402, PMCID: PMC2581632, PII: HYPERTENSIONAHA.107.102574, DOI: 10.1161/HYPERTENSIONAHA.107.102574, ISSN: 1524-4563.

Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin. Pharmacol. Ther [print-electronic]. 2008 Jan; 83(1): 122-9. PMID: 17522594, PII: 6100250, DOI: 10.1038/sj.clpt.6100250, ISSN: 1532-6535.

Luther JM, Gainer JV, Murphey LJ, Yu C, Vaughan DE, Morrow JD, Brown NJ. Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism. Hypertension [print-electronic]. 2006 Dec; 48(6): 1050-7. PMID: 17043157, PII: 01.HYP.0000248135.97380.76, DOI: 10.1161/01.HYP.0000248135.97380.76, ISSN: 1524-4563.

Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Sep; 318(3): 1287-92. PMID: 16772538, PII: jpet.106.104026, DOI: 10.1124/jpet.106.104026, ISSN: 0022-3565.

Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Nov; 25(11): 2435-40. PMID: 16166566, PII: 01.ATV.0000186185.13977.94, DOI: 10.1161/01.ATV.0000186185.13977.94, ISSN: 1524-4636.

Luther JM, Lakey DL, Larson RS, Kallianpur AR, D'Agata E, Cousar JB, Haas DW. Utility of bone marrow biopsy for rapid diagnosis of febrile illnesses in patients with human immunodeficiency virus infection. South. Med. J. 2000 Jul; 93(7): 692-7. PMID: 10923958, ISSN: 0038-4348.

Spector JE, Werkhaven JA, Spector NC, Huang S, Page RN, Baranowski B, Luther M, McGehee B, Reinisch L. Preservation of function and histologic appearance in the injured glottis with topical mitomycin-C. Laryngoscope. 1999 Jul; 109(7 Pt 1): 1125-9. PMID: 10401854, ISSN: 0023-852X.