James David West, Ph.D.


Faculty Appointments
Professor of Medicine Professor of Biomedical Engineering
Ph.D., Informatics, Georgia Institute of Technology, Atlanta, GeorgiaB.S., Physics, University of Missouri, Columbia, Missouri
Office Address
T-1218 MCN
Nashville, TN 2650
Pickworth J, Rothman A, Iremonger J, Casbolt H, Hopkinson K, Hickey PM, Gladson S, Shay S, Morrell NW, Francis SE, West JD, Lawrie A. Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling. Pulm Circ [print-electronic]. 2017 Sep 9/22/2017; 2045893217729096. PMID: 28828907, DOI: 10.1177/2045893217729096, ISSN: 2045-8932.

Suzuki T, Carrier EJ, Talati MA, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West JD. Isolation and characterization of endothelial-to-mesenchymal transition-cells in pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2017 Sep 9/21/2017; ajplung.00296.2017. PMID: 28935639, PII: ajplung.00296.2017, DOI: 10.1152/ajplung.00296.2017, ISSN: 1522-1504.

Copeland CA, Han B, Tiwari A, Austin ED, Loyd JE, West JD, Kenworthy AK. A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal. Mol. Biol. Cell [print-electronic]. 2017 Sep 9/13/2017; PMID: 28904206, PII: mbc.E17-06-0421, DOI: 10.1091/mbc.E17-06-0421, ISSN: 1939-4586.

Trammell AW, Talati M, Blackwell TR, Fortune NL, Niswender KD, Fessel JP, Newman JH, West JD, Hemnes AR. Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension. Pulm Circ [print-electronic]. 2017 Jul; 7(3): 624-34. PMID: 28704134, DOI: 10.1086/689908, ISSN: 2045-8932.

Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J. Clin. Invest [print-electronic]. 2017 Jun 6/1/2017; 127(6): 2262-76. PMID: 28463231, PMCID: PMC5451236, PII: 88629, DOI: 10.1172/JCI88629, ISSN: 1558-8238.

Nickel NP, O'Leary JM, Brittain EL, Fessel JP, Zamanian RT, West JD, Austin ED. Kidney dysfunction in patients with pulmonary arterial hypertension. Pulm Circ. 2017 Mar; 7(1): 38-54. PMID: 28680564, PMCID: PMC5448543, PII: 10.1086_690018, DOI: 10.1086/690018, ISSN: 2045-8932.

Awad KS, West JD, de Jesus Perez V, MacLean M. Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulm Circ. 2016 Sep; 6(3): 285-94. PMID: 27683605, PMCID: PMC5019081, PII: PC2013349, DOI: 10.1086/688034, ISSN: 2045-8932.

Nguyen TT, Caito SW, Zackert WE, West JD, Zhu S, Aschner M, Fessel JP, Roberts LJ. Scavengers of reactive ¿-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging (Albany NY). 2016 Aug; 8(8): 1759-80. PMID: 27514077, PMCID: PMC5032694, PII: 101011, DOI: 10.18632/aging.101011, ISSN: 1945-4589.

Suzuki T, Tada Y, Nishimura R, Kawasaki T, Sekine A, Urushibara T, Kato F, Kinoshita T, Ikari J, West J, Tatsumi K. Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Jun 6/1/2016; 310(11): L1185-98. PMID: 27106288, PII: ajplung.00074.2016, DOI: 10.1152/ajplung.00074.2016, ISSN: 1522-1504.

West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. Pulm Circ. 2016 Jun; 6(2): 211-23. PMID: 27252848, PMCID: PMC4869926, PII: PC2013314, DOI: 10.1086/686140, ISSN: 2045-8932.

Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 May 5/17/2016; 133(20): 1936-44. PMID: 27006481, PMCID: PMC4870107, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.

Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PMCID: PMC4838140, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.

West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD. Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension. PLoS ONE. 2016; 11(2): e0148657. PMID: 26863209, PMCID: PMC4749293, PII: PONE-D-15-46627, DOI: 10.1371/journal.pone.0148657, ISSN: 1932-6203.

Fessel JP, West JD. Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series). Pulm Circ. 2015 Dec; 5(4): 599-609. PMID: 26697167, PMCID: PMC4671734, PII: PC2013233, DOI: 10.1086/683814, ISSN: 2045-8932.

Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD. Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Pulm Circ. 2015 Dec; 5(4): 681-90. PMID: 26697175, PMCID: PMC4671742, PII: PC2013257, DOI: 10.1086/683811, ISSN: 2045-8932.

Bloodworth NC, West JD, Merryman WD. Microvessel mechanobiology in pulmonary arterial hypertension: cause and effect. Hypertension [print-electronic]. 2015 Mar; 65(3): 483-9. PMID: 25534705, PMCID: PMC4326545, PII: HYPERTENSIONAHA.114.04652, DOI: 10.1161/HYPERTENSIONAHA.114.04652, ISSN: 1524-4563.

Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015; 6: 6863. PMID: 25873470, PMCID: PMC4399003, PII: ncomms7863, DOI: 10.1038/ncomms7863, ISSN: 2041-1723.

Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am. J. Physiol., Cell Physiol. 2014 Oct 10/15/2014; 307(8): C684-98. PMID: 25122876, PMCID: PMC4200000, PII: ajpcell.00114.2014, DOI: 10.1152/ajpcell.00114.2014, ISSN: 1522-1563.

West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am. J. Physiol., Cell Physiol [print-electronic]. 2014 Sep 9/1/2014; 307(5): C415-30. PMID: 24871858, PMCID: PMC4154073, PII: ajpcell.00057.2014, DOI: 10.1152/ajpcell.00057.2014, ISSN: 1522-1563.

McDonald BC, Conroy SK, Smith DJ, West JD, Saykin AJ. Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: a replication and extension study. Brain Behav. Immun [print-electronic]. 2013 Mar; 30 Suppl: S117-25. PMID: 22613170, PMCID: PMC3629547, PII: S0889-1591(12)00114-6, DOI: 10.1016/j.bbi.2012.05.007, ISSN: 1090-2139.

Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/1/2012; 186(9): 892-6. PMID: 22923661, PMCID: PMC3530218, PII: rccm.201205-0886OC, DOI: 10.1164/rccm.201205-0886OC, ISSN: 1535-4970.

Swaminathan S, Shen L, Kim S, Inlow M, West JD, Faber KM, Foroud T, Mayeux R, Saykin AJ, , . Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study. Curr Alzheimer Res. 2012 Sep; 9(7): 801-14. PMID: 22486522, PMCID: PMC3500615, PII: CAR-EPUB-20120410-001, ISSN: 1875-5828.

Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR. The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J [print-electronic]. 2012 Jun; 26(6): 2546-57. PMID: 22415303, PMCID: PMC3650483, PII: fj.11-200907, DOI: 10.1096/fj.11-200907, ISSN: 1530-6860.

Fessel JP, Hamid R, Wittmann BM, Robinson LJ, Blackwell T, Tada Y, Tanabe N, Tatsumi K, Hemnes AR, West JD. Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ. 2012 Apr; 2(2): 201-13. PMID: 22837861, PMCID: PMC3401874, PII: PC-2-201, DOI: 10.4103/2045-8932.97606, ISSN: 2045-8940.

Swaminathan S, Shen L, Risacher SL, Yoder KK, West JD, Kim S, Nho K, Foroud T, Inlow M, Potkin SG, Huentelman MJ, Craig DW, Jagust WJ, Koeppe RA, Mathis CA, Jack CR, Weiner MW, Saykin AJ, . Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Brain Imaging Behav. 2012 Mar; 6(1): 1-15. PMID: 21901424, PMCID: PMC3256261, DOI: 10.1007/s11682-011-9136-1, ISSN: 1931-7565.

Wang Y, West JD, Flashman LA, Wishart HA, Santulli RB, Rabin LA, Pare N, Arfanakis K, Saykin AJ. Selective changes in white matter integrity in MCI and older adults with cognitive complaints. Biochim. Biophys. Acta [print-electronic]. 2012 Mar; 1822(3): 423-30. PMID: 21867750, PMCID: PMC3235544, PII: S0925-4439(11)00172-4, DOI: 10.1016/j.bbadis.2011.08.002, ISSN: 0006-3002.

Douvaras P, Liu W, Mort RL, McKie L, West KM, Cross SH, Morley SD, West JD. Normal X-inactivation mosaicism in corneas of heterozygous FlnaDilp2/+ female mice--a model of human filamin A (FLNA) diseases. BMC Res Notes. 2012; 5: 122. PMID: 22369496, PMCID: PMC3305671, PII: 1756-0500-5-122, DOI: 10.1186/1756-0500-5-122, ISSN: 1756-0500.

Kucerova R, Dorà N, Mort RL, Wallace K, Leiper LJ, Lowes C, Neves C, Walczysko P, Bruce F, Fowler PA, Rajnicek AM, McCaig CD, Zhao M, West JD, Collinson JM. Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium. Mol. Vis [print-electronic]. 2012; 18: 139-50. PMID: 22275805, PMCID: PMC3265179, ISSN: 1090-0535.

Douvaras P, Webb S, Whitaker DA, Dorà N, Hill RE, Dorin JR, West JD. Rare corneal clones in mice suggest an age-related decrease of stem cell activity and support the limbal epithelial stem cell hypothesis. Stem Cell Res [print-electronic]. 2012 Jan; 8(1): 109-19. PMID: 22099025, PII: S1873-5061(11)00113-9, DOI: 10.1016/j.scr.2011.08.007, ISSN: 1876-7753.

West JD, Bergstrom CT. Psychology. Can ignorance promote democracy?. Science. 2011 Dec 12/16/2011; 334(6062): 1503-4. PMID: 22174236, PII: 334/6062/1503, DOI: 10.1126/science.1216124, ISSN: 1095-9203.

Chang SP, Mullins JJ, Morley SD, West JD. Transition from organogenesis to stem cell maintenance in the mouse adrenal cortex. Organogenesis. 2011 Oct; 7(4): 267-80. PMID: 22198434, PMCID: PMC3265829, PII: 18060, DOI: 10.4161/org.7.4.18060, ISSN: 1555-8592.

Chang SP, Mullins JJ, Morley SD, West JD. Transition from organogenesis to stem cell maintenance in the mouse adrenal cortex. Organogenesis [print-electronic]. 2011 Oct 10/1/2011; 7(4): PMID: 21964247, PII: 18060, ISSN: 1555-8592.

West JD, Stamm CE, Brown HA, Justice SL, Morano KA. Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chem. Res. Toxicol [print-electronic]. 2011 Sep 9/19/2011; 24(9): 1457-9. PMID: 21812477, DOI: 10.1021/tx200302w, ISSN: 1520-5010.

Hodson BA, Unbekandt M, Keighren MA, Springbett A, West JD. Evaluation of methods for one-dimensional spatial analysis of two-dimensional patterns in mouse chimaeras. J. Anat [print-electronic]. 2011 Sep; 219(3): 418-37. PMID: 21615733, PMCID: PMC3171778, DOI: 10.1111/j.1469-7580.2011.01395.x, ISSN: 1469-7580.

West JD, Stamm CE, Kingsley PJ. Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent. Chem. Res. Toxicol [print-electronic]. 2011 Jan 1/14/2011; 24(1): 81-8. PMID: 21105742, DOI: 10.1021/tx100292n, ISSN: 1520-5010.

Mort RL, Bentley AJ, Martin FL, Collinson JM, Douvaras P, Hill RE, Morley SD, Fullwood NJ, West JD. Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis. PLoS ONE [print-electronic]. 2011; 6(12): e28895. PMID: 22220198, PMCID: PMC3248408, PII: PONE-D-11-13235, DOI: 10.1371/journal.pone.0028895, ISSN: 1932-6203.

McDonald BC, Conroy SK, Ahles TA, West JD, Saykin AJ. Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study. Breast Cancer Res. Treat [print-electronic]. 2010 Oct; 123(3): 819-28. PMID: 20690040, PMCID: PMC3661415, DOI: 10.1007/s10549-010-1088-4, ISSN: 1573-7217.

West JD. The endodontic Glidepath: "Secret to rotary safety". Dent Today. 2010 Sep; 29(9): 86, 88, 90-3. PMID: 20973422, ISSN: 8750-2186.

Risacher SL, Shen L, West JD, Kim S, McDonald BC, Beckett LA, Harvey DJ, Jack CR, Weiner MW, Saykin AJ, . Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort. Neurobiol. Aging. 2010 Aug; 31(8): 1401-18. PMID: 20620664, PMCID: PMC2904350, PII: S0197-4580(10)00204-6, DOI: 10.1016/j.neurobiolaging.2010.04.029, ISSN: 1558-1497.

Dumas JA, McDonald BC, Saykin AJ, McAllister TW, Hynes ML, West JD, Newhouse PA. Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study. Menopause. 2010 Jul; 17(4): 852-9. PMID: 20616672, PMCID: PMC2901886, PII: 00042192-201017040-00031, DOI: 10.1097/gme.0b013e3181e04db9, ISSN: 1530-0374.

Nho K, Shen L, Kim S, Risacher SL, West JD, Foroud T, Jack CR, Weiner MW, Saykin AJ. Automatic Prediction of Conversion from Mild Cognitive Impairment to Probable Alzheimer's Disease using Structural Magnetic Resonance Imaging. AMIA Annu Symp Proc. 2010; 2010: 542-6. PMID: 21347037, PMCID: PMC3041374, ISSN: 1942-597X.

Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, Wheeler LA, Parl FF, Loyd JE, Phillips JA. Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur. Respir. J [print-electronic]. 2009 Nov; 34(5): 1093-9. PMID: 19357154, PMCID: PMC3742124, PII: 09031936.00010409, DOI: 10.1183/09031936.00010409, ISSN: 1399-3003.

West JD, Marnett LJ. Endogenous reactive intermediates as modulators of cell signaling and cell death. Chem. Res. Toxicol. 2006 Feb; 19(2): 173-94. PMID: 16485894, DOI: 10.1021/tx050321u, ISSN: 0893-228X.

West JD, Marnett LJ. Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. Chem. Res. Toxicol. 2005 Nov; 18(11): 1642-53. PMID: 16300372, DOI: 10.1021/tx050211n, ISSN: 0893-228X.

West JD, Ji C, Marnett LJ. Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1. J. Biol. Chem [print-electronic]. 2005 Apr 4/15/2005; 280(15): 15141-7. PMID: 15703174, PII: M413147200, DOI: 10.1074/jbc.M413147200, ISSN: 0021-9258.

West JD, Ji C, Duncan ST, Amarnath V, Schneider C, Rizzo CJ, Brash AR, Marnett LJ. Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation. Chem. Res. Toxicol. 2004 Apr; 17(4): 453-62. PMID: 15089087, DOI: 10.1021/tx034248o, ISSN: 0893-228X.

Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J. Clin. Invest. 2003 Mar; 111(5): 583-93. PMID: 12618510, PMCID: PMC151910, DOI: 10.1172/JCI18022, ISSN: 0021-9738.