Yan X. Liu, M.D.

Research Assistant Professor

yan.x.liu@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
M.S., Fourth Military Medical University, Xi'an, ChinaM.D., Fourth Military Medical University, Xi'an, China
Office Address
T-1218 Medical Center North
1161 21st Avenue South
Nashville, TN 37232-2363
Publications
Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J. The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. J. Biol. Chem. 2014 Aug 8/8/2014; 289(32): 21973-83. PMID: 24958727, PMCID: PMC4139214, PII: M114.588723, DOI: 10.1074/jbc.M114.588723, ISSN: 1083-351X.

Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J. Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. J Am Heart Assoc. 2013 Apr 4/5/2013; 2(2): e000093. PMID: 23563994, PMCID: PMC3647260, PII: 2/2/e000093, DOI: 10.1161/JAHA.113.000093, ISSN: 2047-9980.

Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE. Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. J. Immunol. 2012 Mar 3/15/2012; 188(6): 2493-7. PMID: 22323537, PMCID: PMC3294148, PII: jimmunol.1101502, DOI: 10.4049/jimmunol.1101502, ISSN: 1550-6606.

Moore DJ, Zienkiewicz J, Kendall PL, Liu D, Liu X, Veach RA, Collins RD, Hawiger J. In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. PLoS ONE. 2010; 5(10): e13235. PMID: 20949090, PMCID: PMC2950856, DOI: 10.1371/journal.pone.0013235, ISSN: 1932-6203.

Flynt AS, Thatcher EJ, Burkewitz K, Li N, Liu Y, Patton JG. MiR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos. J. Cell Biol [print-electronic]. 2009 Apr 4/6/2009; 185(1): 115-27. PMID: 19332888, PMCID: PMC2700511, PII: jcb.200807026, DOI: 10.1083/jcb.200807026, ISSN: 1540-8140.

Liu D, Li C, Chen Y, Burnett C, Liu XY, Downs S, Collins RD, Hawiger J. Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide. J. Biol. Chem [print-electronic]. 2004 Nov 11/12/2004; 279(46): 48434-42. PMID: 15345713, PII: M407190200, DOI: 10.1074/jbc.M407190200, ISSN: 0021-9258.

Liu D, Liu XY, Robinson D, Burnett C, Jackson C, Seele L, Veach RA, Downs S, Collins RD, Ballard DW, Hawiger J. Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor. J. Biol. Chem [print-electronic]. 2004 Apr 4/30/2004; 279(18): 19239-46. PMID: 14732709, PII: M313442200, DOI: 10.1074/jbc.M313442200, ISSN: 0021-9258.

Veach RA, Liu D, Yao S, Chen Y, Liu XY, Downs S, Hawiger J. Receptor/transporter-independent targeting of functional peptides across the plasma membrane. J. Biol. Chem [print-electronic]. 2004 Mar 3/19/2004; 279(12): 11425-31. PMID: 14699109, PII: M311089200, DOI: 10.1074/jbc.M311089200, ISSN: 0021-9258.

Liu XY, Robinson D, Veach RA, Liu D, Timmons S, Collins RD, Hawiger J. Peptide-directed suppression of a pro-inflammatory cytokine response. J. Biol. Chem. 2000 Jun 6/2/2000; 275(22): 16774-8. PMID: 10751381, PII: C000083200, DOI: 10.1074/jbc.C000083200, ISSN: 0021-9258.

Hawiger J, Veach RA, Liu XY, Timmons S, Ballard DW. IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. Blood. 1999 Sep 9/1/1999; 94(5): 1711-6. PMID: 10477696, ISSN: 0006-4971.

Zhang L, Torgerson TR, Liu XY, Timmons S, Colosia AD, Hawiger J, Tam JP. Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. Proc. Natl. Acad. Sci. U.S.A. 1998 Aug 8/4/1998; 95(16): 9184-9. PMID: 9689055, PMCID: PMC21313, ISSN: 0027-8424.

Liu XY, Timmons S, Lin YZ, Hawiger J. Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs. Proc. Natl. Acad. Sci. U.S.A. 1996 Oct 10/15/1996; 93(21): 11819-24. PMID: 8876221, PMCID: PMC38142, ISSN: 0027-8424.