David Michael Aronoff, M.D.

Professor

d.aronoff@vanderbilt.edu

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Faculty Appointments
Director, Division of Infectious Diseases Professor of Medicine Addison B. Scoville Jr. Chair in MedicineProfessor of Obstetrics & GynecologyProfessor of Pathology, Microbiology and Immunology
Education
M.D., Tufts University, Medford, MassachusettsB.S., Indiana University, Fort Wayne, Indiana
Office Address
A2200 MCN
1161 21st Ave South
Nashville, TN 2582
Research Description
The overarching goal of the Aronoff lab is to improve human health through discovery, with a primary interest on maternal-child wellness. The Aronoff lab studies reproductive immunology with a focus on bacterial infections that complicate pregnancy. These infections include perinatal streptococcal infections and postpartum clostridial infections. Our major interest is revealing root molecular mechanisms whereby bacterial pathogens evade innate immunity within the female reproductive tract. We also study the impact of metabolic stressors such as obesity and diabetes on reproductive immunology and placental function. Our work with toxigenic clostridia has extended to non-reproductive tract infections, such as colitis caused by Clostridium diffficile. Members of our lab engage in a range of research approaches, from purely bench science to translational science to purely clinical research. We value interdisciplinary team science.
Research Keywords
Reproductive health, DOHaD (Developmental Origins of Health and Disease), aerobic and anaerobic bacterial pathogenesis, and innate immunity
Clinical Research Keywords
Chorioamnionitis Perinatal infections Sepsis Clostridium difficile infection Group A Streptococcus infections Group B Streptococcus infections Endometritis Neonatal sepsis
Publications
Popik W, Correa H, Khatua A, Aronoff DM, Alcendor DJ. Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease. J Transl Sci [print-electronic]. 2019 Feb; 5(1): PMID: 29977613, PMCID: PMC6027753, DOI: 10.15761/JTS.1000248, ISSN: 2059-268X.

Aronoff DM. Honoring Sydney Finegold, Founding President of the Anaerobe Society of the Americas (1921-2018) [editorial]. Anaerobe [print-electronic]. 2018 Nov 11/20/2018; PMID: 30468881, PII: S1075-9964(18)30190-2, DOI: 10.1016/j.anaerobe.2018.11.007, ISSN: 1095-8274.

Doster RS, Sutton JA, Rogers LM, Aronoff DM, Gaddy JA. Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism. MBio. 2018 Nov 11/20/2018; 9(6): PMID: 30459195, PII: mBio.02084-18, DOI: 10.1128/mBio.02084-18, ISSN: 2150-7511.

Li Y, Soendergaard C, Bergenheim FH, Aronoff DM, Milne G, Riis LB, Seidelin JB, Jensen KB, Nielsen OH. COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis. EBioMedicine [print-electronic]. 2018 Oct; 36: 497-507. PMID: 30190207, PMCID: PMC6197735, PII: S2352-3964(18)30329-3, DOI: 10.1016/j.ebiom.2018.08.040, ISSN: 2352-3964.

Rogers LM, Anders AP, Doster RS, Gill EA, Gnecco JS, Holley JM, Randis TM, Ratner AJ, Gaddy JA, Osteen K, Aronoff DM. Decidual stromal cell-derived PGE2 regulates macrophage responses to microbial threat. Am. J. Reprod. Immunol [print-electronic]. 2018 Oct; 80(4): e13032. PMID: 30084522, DOI: 10.1111/aji.13032, ISSN: 1600-0897.

Barke TL, Goldstein JA, Sundermann AC, Reddy AP, Linder JE, Correa H, Velez-Edwards DR, Aronoff DM. Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta. Am. J. Reprod. Immunol [print-electronic]. 2018 Oct; 80(4): e13020. PMID: 29984475, PMCID: PMC6193471, DOI: 10.1111/aji.13020, ISSN: 1600-0897.

Muñoz-Miralles J, Trindade BC, Castro-Córdova P, Bergin IL, Kirk LA, Gil F, Aronoff DM, Paredes-Sabja D. Indomethacin increases severity of Clostridium difficile infection in mouse model. Future Microbiol [print-electronic]. 2018 Sep; 13: 1271-81. PMID: 30238771, PMCID: PMC6190216, DOI: 10.2217/fmb-2017-0311, ISSN: 1746-0921.

Money KM, Barke TL, Serezani A, Gannon M, Garbett KA, Aronoff DM, Mirnics K. Gestational diabetes exacerbates maternal immune activation effects in the developing brain. Mol. Psychiatry [print-electronic]. 2018 Sep; 23(9): 1-9. PMID: 28948973, PII: mp2017191, DOI: 10.1038/mp.2017.191, ISSN: 1476-5578.

Goldstein JA, Bastarache LA, Denny JC, Pulley JM, Aronoff DM. PregOMICS-Leveraging systems biology and bioinformatics for drug repurposing in maternal-child health. Am. J. Reprod. Immunol [print-electronic]. 2018 Aug; 80(2): e12971. PMID: 29726581, PMCID: PMC6105384, DOI: 10.1111/aji.12971, ISSN: 1600-0897.

Clouse K, Fox MP, Mongwenyana C, Motlhatlhedi M, Buthelezi S, Bokaba D, Norris SA, Bassett J, Lurie MN, Aronoff DM, Vermund SH. "I will leave the baby with my mother": Long-distance travel and follow-up care among HIV-positive pregnant and postpartum women in South Africa. J Int AIDS Soc. 2018 Jul; 21 Suppl 4: e25121. PMID: 30027665, PMCID: PMC6053484, DOI: 10.1002/jia2.25121, ISSN: 1758-2652.

Clouse K, Motlhatlhedi M, Bonnet K, Schlundt D, Aronoff DM, Chakkalakal R, Norris SA. "I just wish that everything is in one place": facilitators and barriers to continuity of care among HIV-positive, postpartum women with a non-communicable disease in South Africa. AIDS Care [print-electronic]. 2018 Jun; 30(sup2): 5-10. PMID: 29848002, PMCID: PMC6088383, DOI: 10.1080/09540121.2018.1470308, ISSN: 1360-0451.

Ding T, Lambert LA, Aronoff DM, Osteen KG, Bruner-Tran KL. Sex-Dependent Influence of Developmental Toxicant Exposure on Group B Streptococcus-Mediated Preterm Birth in a Murine Model. Reprod Sci [print-electronic]. 2018 May; 25(5): 662-73. PMID: 29153057, DOI: 10.1177/1933719117741378, ISSN: 1933-7205.

Mendes Neto NN, da Silva Maia JT, Zacarkim MR, Queiroz I, Labeaud AD, Aronoff DM. Perinatal Case Fatality Rate Related to Congenital Zika Syndrome in Brazil: A Cross-Sectional Study. Pediatr. Neurol [print-electronic]. 2018 Apr; 81: 47-8. PMID: 29526344, PII: S0887-8994(17)31131-1, DOI: 10.1016/j.pediatrneurol.2017.11.012, ISSN: 1873-5150.

Aronoff DM, Kazanjian PH. Historical and contemporary features of infections due to Clostridium novyi. Anaerobe [print-electronic]. 2018 Apr; 50: 80-4. PMID: 29471106, PII: S1075-9964(17)30235-4, DOI: 10.1016/j.anaerobe.2017.12.012, ISSN: 1095-8274.

Goldstein JA, Bastarache LA, Denny JC, Roden DM, Pulley JM, Aronoff DM. Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications. Pharmacol. Res [print-electronic]. 2018 Apr; 130: 44-51. PMID: 29448118, PMCID: PMC5965292, PII: S1043-6618(17)31008-3, DOI: 10.1016/j.phrs.2018.02.013, ISSN: 1096-1186.

Moon JM, Aronoff DM, Capra JA, Abbot P, Rokas A. Examination of Signatures of Recent Positive Selection on Genes Involved in Human Sialic Acid Biology. G3 (Bethesda). 2018 Mar 3/28/2018; 8(4): 1315-25. PMID: 29467190, PMCID: PMC5873920, PII: g3.118.200035, DOI: 10.1534/g3.118.200035, ISSN: 2160-1836.

Ackerman DL, Craft KM, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD. Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii. ACS Infect Dis [print-electronic]. 2018 Mar 3/9/2018; 4(3): 315-24. PMID: 29198102, PMCID: PMC6019282, DOI: 10.1021/acsinfecdis.7b00183, ISSN: 2373-8227.

Gendrin C, Vornhagen J, Armistead B, Singh P, Whidbey C, Merillat S, Knupp D, Parker R, Rogers LM, Quach P, Iyer LM, Aravind L, Manning SD, Aronoff DM, Rajagopal L. A Nonhemolytic Group B Streptococcus Strain Exhibits Hypervirulence. J. Infect. Dis. 2018 Mar 3/5/2018; 217(6): 983-7. PMID: 29244079, PMCID: PMC5853813, PII: 4735256, DOI: 10.1093/infdis/jix646, ISSN: 1537-6613.

Pereira PAT, Assis PA, Prado MKB, Ramos SG, Aronoff DM, de Paula-Silva FWG, Sorgi CA, Faccioli LH. Prostaglandins D2 and E2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum. J. Lipid Res [print-electronic]. 2018 Feb; 59(2): 195-206. PMID: 29217623, PMCID: PMC5794416, PII: jlr.M078162, DOI: 10.1194/jlr.M078162, ISSN: 1539-7262.

Eastman AJ, Bergin IL, Chai D, Bassis CM, LeBar W, Oluoch GO, Liechty ER, Nyachieo A, Young VB, Aronoff DM, Patton DL, Bell JD. Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model. J. Infect. Dis. 2018 Jan 1/30/2018; 217(4): 656-66. PMID: 29253201, PMCID: PMC5853867, PII: 4743781, DOI: 10.1093/infdis/jix545, ISSN: 1537-6613.

Rogers LM, Gaddy JA, Manning SD, Aronoff DM. Variation in Macrophage Phagocytosis of Streptococcus agalactiae Does Not Reflect Bacterial Capsular Serotype, Multilocus Sequence Type, or Association with Invasive Infection. Pathog Immun [print-electronic]. 2018; 3(1): 63-71. PMID: 29930990, PMCID: PMC6007880, ISSN: 2469-2964.

Martinez KA, Romano-Keeler J, Zackular JP, Moore DJ, Brucker RM, Hooper C, Meng S, Brown N, Mallal S, Reese J, Aronoff DM, Shin H, Dominguez-Bello MG, Weitkamp JH. Bacterial DNA is present in the fetal intestine and overlaps with that in the placenta in mice. PLoS ONE. 2018; 13(5): e0197439. PMID: 29771989, PMCID: PMC5957394, PII: PONE-D-17-43953, DOI: 10.1371/journal.pone.0197439, ISSN: 1932-6203.

Doster RS, Rogers LM, Gaddy JA, Aronoff DM. Macrophage Extracellular Traps: A Scoping Review. J Innate Immun [print-electronic]. 2018; 10(1): 3-13. PMID: 28988241, PII: 000480373, DOI: 10.1159/000480373, ISSN: 1662-8128.

Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ. When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data. Assay Drug Dev Technol [print-electronic]. 2017 Dec; 15(8): 354-61. PMID: 29193979, PMCID: PMC5731541, DOI: 10.1089/adt.2017.821, ISSN: 1557-8127.

Aronoff DM, Correa H, Rogers LM, Arav-Boger R, Alcendor DJ. Placental pericytes and cytomegalovirus infectivity: Implications for HCMV placental pathology and congenital disease. Am. J. Reprod. Immunol [print-electronic]. 2017 Sep; 78(3): PMID: 28741727, PMCID: PMC5561471, DOI: 10.1111/aji.12728, ISSN: 1600-0897.

Carson WF, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL. The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages. J. Immunol [print-electronic]. 2017 Jul 7/21/2017; PMID: 28733487, PII: jimmunol.1601272, DOI: 10.4049/jimmunol.1601272, ISSN: 1550-6606.

Ackerman DL, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD. Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus. ACS Infect Dis [print-electronic]. 2017 Jun 6/13/2017; PMID: 28570820, DOI: 10.1021/acsinfecdis.7b00064, ISSN: 2373-8227.

Goldstein JA, Norris SA, Aronoff DM. DOHaD at the intersection of maternal immune activation and maternal metabolic stress: a scoping review. J Dev Orig Health Dis [print-electronic]. 2017 Jun; 8(3): 273-83. PMID: 28196555, PII: S2040174417000010, DOI: 10.1017/S2040174417000010, ISSN: 2040-1752.

Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay Drug Dev Technol [print-electronic]. 2017 Apr; 15(3): 113-9. PMID: 28379727, PMCID: PMC5399743, DOI: 10.1089/adt.2016.772, ISSN: 1557-8127.

Prioreschi A, Munthali RJ, Soepnel L, Goldstein JA, Micklesfield LK, Aronoff DM, Norris SA. Incidence and prevalence of type 2 diabetes mellitus with HIV infection in Africa: a systematic review and meta-analysis. BMJ Open. 2017 Mar 3/29/2017; 7(3): e013953. PMID: 28360243, PMCID: PMC5372101, PII: bmjopen-2016-013953, DOI: 10.1136/bmjopen-2016-013953, ISSN: 2044-6055.

Anders AP, Gaddy JA, Doster RS, Aronoff DM. Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells. Am. J. Reprod. Immunol [print-electronic]. 2017 Mar; 77(3): PMID: 28044385, PMCID: PMC5321847, DOI: 10.1111/aji.12623, ISSN: 1600-0897.

Kothary V, Doster RS, Rogers LM, Kirk LA, Boyd KL, Romano-Keeler J, Haley KP, Manning SD, Aronoff DM, Gaddy JA. Group B Streptococcus Induces Neutrophil Recruitment to Gestational Tissues and Elaboration of Extracellular Traps and Nutritional Immunity. Front Cell Infect Microbiol. 2017; 7: 19. PMID: 28217556, PMCID: PMC5289994, DOI: 10.3389/fcimb.2017.00019, ISSN: 2235-2988.

Cha JM, Aronoff DM. A role for cellular senescence in birth timing. Cell Cycle [print-electronic]. 2017; 16(21): 2023-31. PMID: 28873006, PMCID: PMC5731422, DOI: 10.1080/15384101.2017.1371888, ISSN: 1551-4005.

Gnecco JS, Anders AP, Cliffel D, Pensabene V, Rogers LM, Osteen K, Aronoff DM. Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research. Curr. Pharm. Des. 2017; 23(40): 6115-24. PMID: 28847303, PII: CPD-EPUB-85473, DOI: 10.2174/1381612823666170825142649, ISSN: 1873-4286.

Montenegro-Burke JR, Sutton JA, Rogers LM, Milne GL, McLean JA, Aronoff DM. Lipid profiling of polarized human monocyte-derived macrophages. Prostaglandins Other Lipid Mediat [print-electronic]. 2016 Dec; 127: 1-8. PMID: 27871801, PII: S1098-8823(16)30108-3, DOI: 10.1016/j.prostaglandins.2016.11.002, ISSN: 1098-8823.

Kalams SA, Rogers LM, Smith RM, Barnett L, Crumbo K, Sumner S, Prashad N, Rybczyk K, Milne G, Dowd SE, Chong E, Winikoff B, Aronoff DM. Neither vaginal nor buccal administration of 800¿µg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study. Eur J Contracept Reprod Health Care [print-electronic]. 2016 Dec; 21(6): 436-42. PMID: 27636701, DOI: 10.1080/13625187.2016.1229765, ISSN: 1473-0782.

Korir ML, Laut C, Rogers LM, Plemmons JA, Aronoff DM, Manning SD. Differing mechanisms of surviving phagosomal stress among group B Streptococcus strains of varying genotypes. Virulence [print-electronic]. 2016 Oct 10/28/2016; 1-14. PMID: 27791478, DOI: 10.1080/21505594.2016.1252016, ISSN: 2150-5608.

Doster RS, Kirk LA, Tetz LM, Rogers LM, Aronoff DM, Gaddy JA. Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines. J. Infect. Dis [print-electronic]. 2016 Jul 7/19/2016; PMID: 27436434, PII: jiw300, DOI: 10.1093/infdis/jiw300, ISSN: 1537-6613.

Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Jun 6/1/2016; 310(11): L1111-20. PMID: 27059285, PMCID: PMC4935474, PII: ajplung.00220.2015, DOI: 10.1152/ajplung.00220.2015, ISSN: 1522-1504.

Singh P, Aronoff DM, Davies HD, Manning SD. Draft Genome Sequence of an Invasive Streptococcus agalactiae Isolate Lacking Pigmentation. Genome Announc. 2016 Feb 2/25/2016; 4(1): PMID: 26950320, PMCID: PMC4767910, PII: 4/1/e00015-16, DOI: 10.1128/genomeA.00015-16.

Rogers MA, Aronoff DM. The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin. Microbiol. Infect [print-electronic]. 2016 Feb; 22(2): 178.e1-9. PMID: 26482265, PMCID: PMC4754147, PII: S1198-743X(15)00902-7, DOI: 10.1016/j.cmi.2015.10.003, ISSN: 1469-0691.

Kimmel DW, Rogers LM, Aronoff DM, Cliffel DE. Prostaglandin E2 Regulation of Macrophage Innate Immunity. Chem. Res. Toxicol [print-electronic]. 2016 Jan 1/19/2016; 29(1): 19-25. PMID: 26656203, DOI: 10.1021/acs.chemrestox.5b00322, ISSN: 1520-5010.

Aronoff DM. Building a Better Crystal Ball for Predicting Complications of Clostridium difficile Infection [editorial]. Clin. Infect. Dis [print-electronic]. 2015 Dec 12/15/2015; 61(12): 1789-91. PMID: 26338793, PMCID: PMC4657540, PII: civ751, DOI: 10.1093/cid/civ751, ISSN: 1537-6591.

Rao K, Young VB, Aronoff DM. Reply to Planche et al [letter]. Clin. Infect. Dis [print-electronic]. 2015 Oct 10/1/2015; 61(7): 1211-2. PMID: 26092487, PMCID: PMC4560910, PII: civ480, DOI: 10.1093/cid/civ480, ISSN: 1537-6591.

Micic D, Rao K, Trindade BC, Walk ST, Chenoweth E, Jain R, Trivedi I, Santhosh K, Young VB, Aronoff DM. Serum 25-Hydroxyvitamin D Levels are not Associated with Adverse Outcomes in Clostridium Difficile Infection. Infect Dis Rep. 2015 Aug 8/11/2015; 7(3): 5979. PMID: 26500740, PMCID: PMC4593886, DOI: 10.4081/idr.2015.5979, ISSN: 2036-7430.

Rao K, Micic D, Natarajan M, Winters S, Kiel MJ, Walk ST, Santhosh K, Mogle JA, Galecki AT, LeBar W, Higgins PD, Young VB, Aronoff DM. Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Clin. Infect. Dis [print-electronic]. 2015 Jul 7/15/2015; 61(2): 233-41. PMID: 25828993, PMCID: PMC4565993, PII: civ254, DOI: 10.1093/cid/civ254, ISSN: 1537-6591.

Tetz LM, Aronoff DM, Loch-Caruso R. Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells. Reprod. Biol. Endocrinol. 2015 Jun 6/3/2015; 13: 56. PMID: 26036283, PMCID: PMC4462084, PII: 10.1186/s12958-015-0046-8, DOI: 10.1186/s12958-015-0046-8, ISSN: 1477-7827.

Carlson PE, Kaiser AM, McColm SA, Bauer JM, Young VB, Aronoff DM, Hanna PC. Variation in germination of Clostridium difficile clinical isolates correlates to disease severity. Anaerobe [print-electronic]. 2015 Jun; 33: 64-70. PMID: 25681667, PMCID: PMC4467518, PII: S1075-9964(15)00024-4, DOI: 10.1016/j.anaerobe.2015.02.003, ISSN: 1095-8274.

Kopliku FA, Schubert AM, Mogle J, Schloss PD, Young VB, Aronoff DM. Low prevalence of Clostridium septicum fecal carriage in an adult population. Anaerobe [print-electronic]. 2015 Apr; 32: 34-6. PMID: 25481351, PMCID: PMC4385462, PII: S1075-9964(14)00175-9, DOI: 10.1016/j.anaerobe.2014.12.001, ISSN: 1095-8274.

Boldenow E, Hogan KA, Chames MC, Aronoff DM, Xi C, Loch-Caruso R. Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am. J. Reprod. Immunol [print-electronic]. 2015 Mar; 73(3): 263-72. PMID: 25263616, PMCID: PMC4323989, DOI: 10.1111/aji.12325, ISSN: 1600-0897.

Abdelsattar ZM, Krapohl G, Alrahmani L, Banerjee M, Krell RW, Wong SL, Campbell DA, Aronoff DM, Hendren S. Postoperative burden of hospital-acquired Clostridium difficile infection. Infect Control Hosp Epidemiol. 2015 Jan; 36(1): 40-6. PMID: 25627760, PMCID: PMC4597881, PII: S0899823X14000087, DOI: 10.1017/ice.2014.8, ISSN: 1559-6834.

Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H. Identification of toxemia in patients with Clostridium difficile infection. PLoS ONE. 2015; 10(4): e0124235. PMID: 25885671, PMCID: PMC4401762, PII: PONE-D-14-44970, DOI: 10.1371/journal.pone.0124235, ISSN: 1932-6203.

Natarajan M, Rogers MA, Bundy J, Micic D, Walk ST, Santhosh K, Rao K, Winters S, Young VB, Aronoff DM. Gender Differences in Non-Toxigenic Clostridium difficile Colonization and Risk of Subsequent C. difficile Infection. Clin Res Infect Dis [print-electronic]. 2015; 2(2): PMID: 28713874.

Trindade BC, Theriot CM, Leslie JL, Carlson PE, Bergin IL, Peters-Golden M, Young VB, Aronoff DM. Clostridium difficile-induced colitis in mice is independent of leukotrienes. Anaerobe [print-electronic]. 2014 Dec; 30: 90-8. PMID: 25230329, PMCID: PMC4258124, PII: S1075-9964(14)00127-9, DOI: 10.1016/j.anaerobe.2014.09.006, ISSN: 1095-8274.

Korir ML, Knupp D, LeMerise K, Boldenow E, Loch-Caruso R, Aronoff DM, Manning SD. Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect. Immun [print-electronic]. 2014 Nov; 82(11): 4587-95. PMID: 25135682, PMCID: PMC4249324, PII: IAI.02181-14, DOI: 10.1128/IAI.02181-14, ISSN: 1098-5522.

Huang AM, Marini BL, Frame D, Aronoff DM, Nagel JL. Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients. Transpl Infect Dis [print-electronic]. 2014 Oct; 16(5): 744-50. PMID: 25040545, DOI: 10.1111/tid.12267, ISSN: 1399-3062.

Bauer ME, Bauer ST, Rajala B, MacEachern MP, Polley LS, Childers D, Aronoff DM. Maternal physiologic parameters in relationship to systemic inflammatory response syndrome criteria: a systematic review and meta-analysis. Obstet Gynecol. 2014 Sep; 124(3): 535-41. PMID: 25162253, PII: 00006250-201409000-00009, DOI: 10.1097/AOG.0000000000000423, ISSN: 1873-233X.

Islam J, Taylor AL, Rao K, Huffnagle G, Young VB, Rajkumar C, Cohen J, Papatheodorou P, Aronoff DM, Llewelyn MJ. The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study. Anaerobe [print-electronic]. 2014 Jun; 27: 82-6. PMID: 24708941, PMCID: PMC4140433, PII: S1075-9964(14)00030-4, DOI: 10.1016/j.anaerobe.2014.03.011, ISSN: 1095-8274.

Schubert AM, Rogers MA, Ring C, Mogle J, Petrosino JP, Young VB, Aronoff DM, Schloss PD. Microbiome data distinguish patients with Clostridium difficile infection and non-C. difficile-associated diarrhea from healthy controls. MBio. 2014 May 5/6/2014; 5(3): e01021-14. PMID: 24803517, PMCID: PMC4010826, PII: mBio.01021-14, DOI: 10.1128/mBio.01021-14, ISSN: 2150-7511.

Aronoff DM. Editorial commentary: Host-pathogen interactions in Clostridium difficile infection: it takes two to tango [editorial]. Clin. Infect. Dis [print-electronic]. 2014 May; 58(10): 1401-3. PMID: 24604896, PMCID: PMC4001291, PII: ciu141, DOI: 10.1093/cid/ciu141, ISSN: 1537-6591.

Hashway SA, Bergin IL, Bassis CM, Uchihashi M, Schmidt KC, Young VB, Aronoff DM, Patton DL, Bell JD. Impact of a hormone-releasing intrauterine system on the vaginal microbiome: a prospective baboon model. J. Med. Primatol [print-electronic]. 2014 Apr; 43(2): 89-99. PMID: 24266633, PMCID: PMC3954920, DOI: 10.1111/jmp.12090, ISSN: 1600-0684.

Zaslona Z, Okunishi K, Bourdonnay E, Domingo-Gonzalez R, Moore BB, Lukacs NW, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. J. Allergy Clin. Immunol [print-electronic]. 2014 Feb; 133(2): 379-87. PMID: 24075232, PMCID: PMC3960315, PII: S0091-6749(13)01210-4, DOI: 10.1016/j.jaci.2013.07.037, ISSN: 1097-6825.

Rogers LM, Thelen T, Fordyce K, Bourdonnay E, Lewis C, Yu H, Zhang J, Xie J, Serezani CH, Peters-Golden M, Aronoff DM. EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii. Am. J. Reprod. Immunol [print-electronic]. 2014 Jan; 71(1): 34-43. PMID: 23902376, PMCID: PMC3864121, DOI: 10.1111/aji.12153, ISSN: 1600-0897.

Mancuso P, O Brien E, Prano J, Goel D, Aronoff DM. No Impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice. PLoS ONE. 2014; 9(9): e106420. PMID: 25203099, PMCID: PMC4159279, PII: PONE-D-14-28469, DOI: 10.1371/journal.pone.0106420, ISSN: 1932-6203.

Canavaci AM, Sorgi CA, Martins VP, Morais FR, de Sousa ÉV, Trindade BC, Cunha FQ, Rossi MA, Aronoff DM, Faccioli LH, Nomizo A. The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Mediators Inflamm [print-electronic]. 2014; 2014: 893634. PMID: 25165415, PMCID: PMC4137569, DOI: 10.1155/2014/893634, ISSN: 1466-1861.

Rao K, Erb-Downward JR, Walk ST, Micic D, Falkowski N, Santhosh K, Mogle JA, Ring C, Young VB, Huffnagle GB, Aronoff DM. The systemic inflammatory response to Clostridium difficile infection. PLoS ONE. 2014; 9(3): e92578. PMID: 24643077, PMCID: PMC3958555, PII: PONE-D-13-43374, DOI: 10.1371/journal.pone.0092578, ISSN: 1932-6203.

Rogers MA, Micic D, Blumberg N, Young VB, Aronoff DM. Storage duration of red blood cell transfusion and Clostridium difficile infection: a within person comparison. PLoS ONE. 2014; 9(2): e89332. PMID: 24586694, PMCID: PMC3931729, PII: PONE-D-13-42587, DOI: 10.1371/journal.pone.0089332, ISSN: 1932-6203.

Rao K, Young VB, Aronoff DM. Fecal microbiota therapy: ready for prime time?. Infect Control Hosp Epidemiol [print-electronic]. 2014 Jan; 35(1): 28-30. PMID: 24334795, PMCID: PMC4131295, DOI: 10.1086/674395, ISSN: 1559-6834.

Aronoff DM. Clostridium novyi, sordellii, and tetani: mechanisms of disease. Anaerobe [print-electronic]. 2013 Dec; 24: 98-101. PMID: 24036420, PII: S1075-9964(13)00141-8, DOI: 10.1016/j.anaerobe.2013.08.009, ISSN: 1095-8274.

Aronoff DM, Marrazzo JM, Sears CL. Introduction to the special issue highlighting Anaerobe 2012 [editorial]. Anaerobe [print-electronic]. 2013 Dec; 24: 85-6. PMID: 23999247, PII: S1075-9964(13)00140-6, DOI: 10.1016/j.anaerobe.2013.08.008, ISSN: 1095-8274.

Carlson PE, Walk ST, Bourgis AE, Liu MW, Kopliku F, Lo E, Young VB, Aronoff DM, Hanna PC. The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates. Anaerobe [print-electronic]. 2013 Dec; 24: 109-16. PMID: 23608205, PMCID: PMC4038106, PII: S1075-9964(13)00057-7, DOI: 10.1016/j.anaerobe.2013.04.003, ISSN: 1095-8274.

Rogers MA, Aronoff DM. Depression and clostridium difficile infection [letter]. J Psychosoc Nurs Ment Health Serv. 2013 Oct; 51(10): 5. PMID: 24093925, DOI: 10.3928/02793695-20130903-01, ISSN: 0279-3695.

Rao K, Micic D, Chenoweth E, Deng L, Galecki AT, Ring C, Young VB, Aronoff DM, Malani PN. Poor functional status as a risk factor for severe Clostridium difficile infection in hospitalized older adults. J Am Geriatr Soc [print-electronic]. 2013 Oct; 61(10): 1738-42. PMID: 24083842, PMCID: PMC3801297, DOI: 10.1111/jgs.12442, ISSN: 1532-5415.

Depestel DD, Aronoff DM. Epidemiology of Clostridium difficile infection. J Pharm Pract. 2013 Oct; 26(5): 464-75. PMID: 24064435, PMCID: PMC4128635, PII: 26/5/464, DOI: 10.1177/0897190013499521, ISSN: 1531-1937.

Behroozian AA, Chludzinski JP, Lo ES, Ewing SA, Waslawski S, Newton DW, Young VB, Aronoff DM, Walk ST. Detection of mixed populations of Clostridium difficile from symptomatic patients using capillary-based polymerase chain reaction ribotyping. Infect Control Hosp Epidemiol [print-electronic]. 2013 Sep; 34(9): 961-6. PMID: 23917911, PMCID: PMC4016961, DOI: 10.1086/671728, ISSN: 1559-6834.

Mason KL, Rogers LM, Soares EM, Bani-Hashemi T, Erb Downward J, Agnew D, Peters-Golden M, Weinberg JB, Crofford LJ, Aronoff DM. Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2. J. Immunol [print-electronic]. 2013 Sep 9/1/2013; 191(5): 2457-65. PMID: 23913961, PMCID: PMC3750066, PII: jimmunol.1300786, DOI: 10.4049/jimmunol.1300786, ISSN: 1550-6606.

Natarajan M, Walk ST, Young VB, Aronoff DM. A clinical and epidemiological review of non-toxigenic Clostridium difficile. Anaerobe [print-electronic]. 2013 Aug; 22: 1-5. PMID: 23727391, PMCID: PMC3729612, PII: S1075-9964(13)00086-3, DOI: 10.1016/j.anaerobe.2013.05.005, ISSN: 1095-8274.

Walk ST, Micic D, Galecki AT, Young VB, Aronoff DM. Understanding increased mortality in Clostridium difficile-infected older adults [letter]. Clin. Infect. Dis [print-electronic]. 2013 Aug; 57(4): 625-6. PMID: 23658435, PMCID: PMC3719887, PII: cit310, DOI: 10.1093/cid/cit310, ISSN: 1537-6591.

Boldenow E, Jones S, Lieberman RW, Chames MC, Aronoff DM, Xi C, Loch-Caruso R. Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture. Placenta [print-electronic]. 2013 Jun; 34(6): 480-5. PMID: 23562109, PMCID: PMC3664555, PII: S0143-4004(13)00134-3, DOI: 10.1016/j.placenta.2013.02.010, ISSN: 1532-3102.

Waslawski S, Lo ES, Ewing SA, Young VB, Aronoff DM, Sharp SE, Novak-Weekley SM, Crist AE, Dunne WM, Hoppe-Bauer J, Johnson M, Brecher SM, Newton DW, Walk ST. Clostridium difficile ribotype diversity at six health care institutions in the United States. J. Clin. Microbiol [print-electronic]. 2013 Jun; 51(6): 1938-41. PMID: 23554188, PMCID: PMC3716112, PII: JCM.00056-13, DOI: 10.1128/JCM.00056-13, ISSN: 1098-660X.

Walk ST, Micic D, Galecki AT, Rogers MA, Washer L, Newton DW, Malani PN, Young VB, Aronoff DM. Reply to Walker et al [letter]. Clin. Infect. Dis [print-electronic]. 2013 Jun; 56(12): 1846-7. PMID: 23420819, PMCID: PMC3888128, PII: cit099, DOI: 10.1093/cid/cit099, ISSN: 1537-6591.

Krapohl GL, Morris AM, Cai S, Englesbe MJ, Aronoff DM, Campbell DA, Hendren S. Preoperative risk factors for postoperative Clostridium difficile infection in colectomy patients. Am. J. Surg [print-electronic]. 2013 Mar; 205(3): 343-7; discussion 347. PMID: 23375705, PMCID: PMC4119815, PII: S0002-9610(13)00030-5, DOI: 10.1016/j.amjsurg.2012.10.028, ISSN: 1879-1883.

Walk ST, Micic D, Galecki AT, Rogers MA, Washer L, Newton DW, Malani PN, Young VB, Aronoff DM. Reply to McDonald [letter]. Clin. Infect. Dis [print-electronic]. 2013 Mar; 56(6): 907-8. PMID: 23196958, PMCID: PMC3590029, PII: cis1003, DOI: 10.1093/cid/cis1003, ISSN: 1537-6591.

Bell JD, Bergin IL, Natavio MF, Jibrel F, Zochowski MK, Weadock WJ, Swanson SD, Aronoff DM, Patton DL. Feasibility of LNG-IUS in a baboon model. Contraception [print-electronic]. 2013 Mar; 87(3): 380-4. PMID: 23114737, PMCID: PMC3565102, PII: S0010-7824(12)00798-6, DOI: 10.1016/j.contraception.2012.08.032, ISSN: 1879-0518.

Soares EM, Mason KL, Rogers LM, Serezani CH, Faccioli LH, Aronoff DM. Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1614-22. PMID: 23325886, PMCID: PMC3563855, PII: jimmunol.1202932, DOI: 10.4049/jimmunol.1202932, ISSN: 1550-6606.

Jain R, Walk ST, Aronoff DM, Young VB, Newton DW, Chenoweth CE, Washer LL. Emergence of Carbapenemaseproducing Klebsiella Pneumoniae of Sequence type 258 in Michigan, USA. Infect Dis Rep. 2013 Jan 1/22/2013; 5(1): e5. PMID: 24470956, PMCID: PMC3892616, DOI: 10.4081/idr.2013.e5, ISSN: 2036-7430.

Rogers MA, Greene MT, Young VB, Saint S, Langa KM, Kao JY, Aronoff DM. Depression, antidepressant medications, and risk of Clostridium difficile infection. BMC Med. 2013; 11: 121. PMID: 23647647, PMCID: PMC3651296, PII: 1741-7015-11-121, DOI: 10.1186/1741-7015-11-121, ISSN: 1741-7015.

Rao K, Walk ST, Micic D, Chenoweth E, Deng L, Galecki AT, Jain R, Trivedi I, Yu M, Santhosh K, Ring C, Young VB, Huffnagle GB, Aronoff DM. Procalcitonin levels associate with severity of Clostridium difficile infection. PLoS ONE [print-electronic]. 2013; 8(3): e58265. PMID: 23505476, PMCID: PMC3591407, PII: PONE-D-12-30843, DOI: 10.1371/journal.pone.0058265, ISSN: 1932-6203.

McCarthy MK, Levine RE, Procario MC, McDonnell PJ, Zhu L, Mancuso P, Crofford LJ, Aronoff DM, Weinberg JB. Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. PLoS ONE. 2013; 8(10): e77628. PMID: 24147040, PMCID: PMC3797793, PII: PONE-D-13-22956, DOI: 10.1371/journal.pone.0077628, ISSN: 1932-6203.

Bergin IL, Bell JD, Chen Z, Zochowski MK, Chai D, Schmidt K, Culmer DL, Aronoff DM, Patton DL, Mwenda JM, Wood CE, Burk RD. Novel genital alphapapillomaviruses in baboons (Papio hamadryas anubis) with cervical dysplasia. Vet. Pathol [print-electronic]. 2013 Jan; 50(1): 200-8. PMID: 22446324, PMCID: PMC3963400, PII: 0300985812439725, DOI: 10.1177/0300985812439725, ISSN: 1544-2217.

Walk ST, Micic D, Jain R, Lo ES, Trivedi I, Liu EW, Almassalha LM, Ewing SA, Ring C, Galecki AT, Rogers MA, Washer L, Newton DW, Malani PN, Young VB, Aronoff DM. Clostridium difficile ribotype does not predict severe infection. Clin. Infect. Dis [print-electronic]. 2012 Dec; 55(12): 1661-8. PMID: 22972866, PMCID: PMC3501335, PII: cis786, DOI: 10.1093/cid/cis786, ISSN: 1537-6591.

Mancuso P, Myers MG, Goel D, Serezani CH, O'Brien E, Goldberg J, Aronoff DM, Peters-Golden M. Ablation of leptin receptor-mediated ERK activation impairs host defense against Gram-negative pneumonia. J. Immunol [print-electronic]. 2012 Jul 7/15/2012; 189(2): 867-75. PMID: 22685316, PMCID: PMC3392451, PII: jimmunol.1200465, DOI: 10.4049/jimmunol.1200465, ISSN: 1550-6606.

Bourdonnay E, Serezani CH, Aronoff DM, Peters-Golden M. Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2. J. Leukoc. Biol [print-electronic]. 2012 Jul; 92(1): 219-31. PMID: 22544939, PMCID: PMC3382311, PII: jlb.1211590, DOI: 10.1189/jlb.1211590, ISSN: 1938-3673.

Aronoff DM, Bergin IL, Lewis C, Goel D, O'Brien E, Peters-Golden M, Mancuso P. E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins Other Lipid Mediat [print-electronic]. 2012 May; 98(1-2): 23-30. PMID: 22575745, PMCID: PMC3350638, PII: S1098-8823(12)00039-1, DOI: 10.1016/j.prostaglandins.2012.03.002, ISSN: 1098-8823.

Zaslona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M. Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood [print-electronic]. 2012 Mar 3/8/2012; 119(10): 2358-67. PMID: 22234697, PMCID: PMC3311259, PII: blood-2011-08-374207, DOI: 10.1182/blood-2011-08-374207, ISSN: 1528-0020.

Aronoff DM, Bartkowiak BA. A review of the website TeamScience.net. Clin Med Res. 2012 Feb; 10(1): 38-9. PMID: 22338090, PMCID: PMC3280455, PII: 10/1/38, DOI: 10.3121/cmr.2011.1066, ISSN: 1554-6179.

Mason KL, Aronoff DM. Postpartum group a Streptococcus sepsis and maternal immunology. Am. J. Reprod. Immunol [print-electronic]. 2012 Feb; 67(2): 91-100. PMID: 22023345, PMCID: PMC3253187, DOI: 10.1111/j.1600-0897.2011.01083.x, ISSN: 1600-0897.

Wilson M, Martin R, Walk ST, Young C, Grossman S, McKean EL, Aronoff DM. Clinical and laboratory features of Streptococcus salivarius meningitis: a case report and literature review. Clin Med Res [print-electronic]. 2012 Feb; 10(1): 15-25. PMID: 21817122, PMCID: PMC3280456, PII: cmr.2011.1001, DOI: 10.3121/cmr.2011.1001, ISSN: 1554-6179.

Rogers MA, Greene MT, Saint S, Chenoweth CE, Malani PN, Trivedi I, Aronoff DM. Higher rates of Clostridium difficile infection among smokers. PLoS ONE [print-electronic]. 2012; 7(7): e42091. PMID: 22848714, PMCID: PMC3407081, PII: PONE-D-11-08927, DOI: 10.1371/journal.pone.0042091, ISSN: 1932-6203.

Aronoff DM. Cyclooxygenase inhibition in sepsis: is there life after death?. Mediators Inflamm [print-electronic]. 2012; 2012: 696897. PMID: 22665954, PMCID: PMC3361325, DOI: 10.1155/2012/696897, ISSN: 1466-1861.

Theriot CM, Koumpouras CC, Carlson PE, Bergin II, Aronoff DM, Young VB. Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains. Gut Microbes [print-electronic]. 2011 Nov; 2(6): 326-34. PMID: 22198617, PMCID: PMC3337121, PII: 19142, DOI: 10.4161/gmic.19142, ISSN: 1949-0984.

Bell JD, Bergin IL, Harris LH, Chai D, Mullei I, Mwenda J, Dalton VK, Vahratian A, Lebar W, Zochowski MK, Kiulia N, Aronoff DM, Patton DL. The effects of a single cervical inoculation of Chlamydia trachomatis on the female reproductive tract of the baboon (Papio anubis). J. Infect. Dis [print-electronic]. 2011 Nov; 204(9): 1305-12. PMID: 21921205, PMCID: PMC3218649, PII: jir541, DOI: 10.1093/infdis/jir541, ISSN: 1537-6613.

Walk ST, Jain R, Trivedi I, Grossman S, Newton DW, Thelen T, Hao Y, Songer JG, Carter GP, Lyras D, Young VB, Aronoff DM. Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia. Anaerobe [print-electronic]. 2011 Oct; 17(5): 252-6. PMID: 21726656, PMCID: PMC3183353, PII: S1075-9964(11)00117-X, DOI: 10.1016/j.anaerobe.2011.06.009, ISSN: 1095-8274.

Aronoff DM, Johnson S, Lorber B. Introduction to the special issue highlighting Anaerobe 2010 [editorial]. Anaerobe [print-electronic]. 2011 Aug; 17(4): 135-6. PMID: 21782961, PII: S1075-9964(11)00132-6, DOI: 10.1016/j.anaerobe.2011.07.002, ISSN: 1095-8274.

Smith MH, Harms PW, Newton DW, Lebar B, Edwards SP, Aronoff DM. Mandibular Actinomyces osteomyelitis complicating florid cemento-osseous dysplasia: case report. BMC Oral Health. 2011 Jul 7/21/2011; 11: 21. PMID: 21777471, PMCID: PMC3151221, PII: 1472-6831-11-21, DOI: 10.1186/1472-6831-11-21, ISSN: 1472-6831.

Machado ER, Carlos D, Sorgi CA, Ramos SG, Souza DI, Soares EG, Costa-Cruz JM, Ueta MT, Aronoff DM, Faccioli LH. Dexamethasone effects in the Strongyloides venezuelensis infection in a murine model. Am. J. Trop. Med. Hyg. 2011 Jun; 84(6): 957-66. PMID: 21633034, PMCID: PMC3110371, PII: 84/6/957, DOI: 10.4269/ajtmh.2011.10-0490, ISSN: 1476-1645.

Kim SH, Serezani CH, Okunishi K, Zaslona Z, Aronoff DM, Peters-Golden M. Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages. J. Biol. Chem [print-electronic]. 2011 Mar 3/18/2011; 286(11): 8875-83. PMID: 21247892, PMCID: PMC3058957, PII: M110.187815, DOI: 10.1074/jbc.M110.187815, ISSN: 1083-351X.

Carter GP, Awad MM, Hao Y, Thelen T, Bergin IL, Howarth PM, Seemann T, Rood JI, Aronoff DM, Lyras D. TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714. Infect. Immun [print-electronic]. 2011 Mar; 79(3): 1025-32. PMID: 21199912, PMCID: PMC3067498, PII: IAI.00968-10, DOI: 10.1128/IAI.00968-10, ISSN: 1098-5522.

Bitencourt CS, Pereira PA, Ramos SG, Sampaio SV, Arantes EC, Aronoff DM, Faccioli LH. Hyaluronidase recruits mesenchymal-like cells to the lung and ameliorates fibrosis. Fibrogenesis Tissue Repair. 2011 Jan 1/13/2011; 4(1): 3. PMID: 21232095, PMCID: PMC3035036, PII: 1755-1536-4-3, DOI: 10.1186/1755-1536-4-3, ISSN: 1755-1536.

Bell JD, Bergin IL, Schmidt K, Zochowski MK, Aronoff DM, Patton DL. Nonhuman primate models used to study pelvic inflammatory disease caused by Chlamydia trachomatis. Infect Dis Obstet Gynecol [print-electronic]. 2011; 2011: 675360. PMID: 21869858, PMCID: PMC3160047, DOI: 10.1155/2011/675360, ISSN: 1098-0997.

Aronoff DM. Another miracle left in aspirin?. Blood. 2010 Oct 10/21/2010; 116(16): 2866-7. PMID: 20966173, PII: 116/16/2866, DOI: 10.1182/blood-2010-07-296756, ISSN: 1528-0020.

Thelen T, Hao Y, Medeiros AI, Curtis JL, Serezani CH, Kobzik L, Harris LH, Aronoff DM. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. J. Immunol [print-electronic]. 2010 Oct 10/1/2010; 185(7): 4328-35. PMID: 20810988, PII: jimmunol.1000989, DOI: 10.4049/jimmunol.1000989, ISSN: 1550-6606.

Aronoff DM. The first year of Infectious Disease Reports. Infect Dis Rep. 2010 Aug 8/4/2010; 2(2): e16. PMID: 24470896, PMCID: PMC3892579, PII: idr.2010.e16, DOI: 10.4081/idr.2010.e16, ISSN: 2036-7430.

Kachman MT, Hurley MC, Thiele T, Srinivas G, Aronoff DM. Comparative analysis of the extracellular proteomes of two Clostridium sordellii strains exhibiting contrasting virulence. Anaerobe [print-electronic]. 2010 Aug; 16(4): 454-60. PMID: 20338254, PMCID: PMC2919616, PII: S1075-9964(10)00030-2, DOI: 10.1016/j.anaerobe.2010.03.004, ISSN: 1095-8274.

Aronoff DM, Bartkowiak BA. A review of the medical weblog, Clinical Correlations. Clin Med Res. 2010 Jul; 8(2): 104-5. PMID: 20660935, PMCID: PMC2910104, PII: 8/2/104, DOI: 10.3121/cmr.2010.926, ISSN: 1554-6179.

Aronoff DM, Thelen T, Walk ST, Petersen K, Jackson J, Grossman S, Rudrik J, Newton DW, Chenoweth CE. Pseudo-outbreak of Clostridium sordellii infection following probable cross-contamination in a hospital clinical microbiology laboratory. Infect Control Hosp Epidemiol. 2010 Jun; 31(6): 640-2. PMID: 20412011, PMCID: PMC3086061, DOI: 10.1086/652774, ISSN: 1559-6834.

Machado ER, Carlos D, Lourenço EV, Souza GE, Sorgi CA, Silva EV, Ueta MT, Ramos SG, Aronoff DM, Faccioli LH. Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection. FEMS Immunol. Med. Microbiol [print-electronic]. 2010 Jun 6/1/2010; 59(1): 18-32. PMID: 20236322, PII: FIM656, DOI: 10.1111/j.1574-695X.2010.00656.x, ISSN: 1574-695X.

Hao Y, Senn T, Opp JS, Young VB, Thiele T, Srinivas G, Huang SK, Aronoff DM. Lethal toxin is a critical determinant of rapid mortality in rodent models of Clostridium sordellii endometritis. Anaerobe [print-electronic]. 2010 Apr; 16(2): 155-60. PMID: 19527792, PMCID: PMC2856776, PII: S1075-9964(09)00087-0, DOI: 10.1016/j.anaerobe.2009.06.002, ISSN: 1095-8274.

Phipps JC, Aronoff DM, Curtis JL, Goel D, O'Brien E, Mancuso P. Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae. Infect. Immun [print-electronic]. 2010 Mar; 78(3): 1214-20. PMID: 20008540, PMCID: PMC2825918, PII: IAI.00963-09, DOI: 10.1128/IAI.00963-09, ISSN: 1098-5522.

Aronoff DM, Ballard JD. Clostridium sordellii toxic shock syndrome [letter]. Lancet Infect Dis. 2009 Dec; 9(12): 725-6. PMID: 19926032, PII: S1473-3099(09)70303-2, DOI: 10.1016/S1473-3099(09)70303-2, ISSN: 1474-4457.

Big C, Reineck LA, Aronoff DM. Viral infections of the central nervous system: a case-based review. Clin Med Res [print-electronic]. 2009 Dec; 7(4): 142-6. PMID: 19889944, PMCID: PMC2801692, PII: cmr.2009.864, DOI: 10.3121/cmr.2009.864, ISSN: 1554-6179.

Aronoff DM. And then there were none: the consequences of academia losing clinically excellent physicians [editorial]. Clin Med Res [print-electronic]. 2009 Dec; 7(4): 125-6. PMID: 19889942, PMCID: PMC2801693, PII: cmr.2009.878, DOI: 10.3121/cmr.2009.878, ISSN: 1554-6179.

Sagana RL, Yan M, Cornett AM, Tsui JL, Stephenson DA, Huang SK, Moore BB, Ballinger MN, Melonakos J, Kontos CD, Aronoff DM, Peters-Golden M, White ES. Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. J. Biol. Chem [print-electronic]. 2009 Nov 11/20/2009; 284(47): 32264-71. PMID: 19808686, PMCID: PMC2781639, PII: M109.004796, DOI: 10.1074/jbc.M109.004796, ISSN: 1083-351X.

Wada M, Saunders TL, Morrow J, Milne GL, Walker KP, Dey SK, Brock TG, Opp MR, Aronoff DM, Smith WL. Two pathways for cyclooxygenase-2 protein degradation in vivo. J. Biol. Chem [print-electronic]. 2009 Nov 11/6/2009; 284(45): 30742-53. PMID: 19758985, PMCID: PMC2781473, PII: M109.052415, DOI: 10.1074/jbc.M109.052415, ISSN: 1083-351X.

Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood [print-electronic]. 2009 Oct 10/8/2009; 114(15): 3316-24. PMID: 19657115, PMCID: PMC2759654, PII: blood-2009-01-199919, DOI: 10.1182/blood-2009-01-199919, ISSN: 1528-0020.

Aronoff DM. Welcome to Infectious Disease Reports: a message from the Editor. Infect Dis Rep. 2009 Sep 9/14/2009; 1(1): e1. PMID: 24470879, PMCID: PMC3892566, PII: idr.2009.e1, DOI: 10.4081/idr.2009.e1, ISSN: 2036-7430.

Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J. Immunol [print-electronic]. 2009 Aug 8/15/2009; 183(4): 2642-9. PMID: 19635910, PMCID: PMC4016992, PII: jimmunol.0900129, DOI: 10.4049/jimmunol.0900129, ISSN: 1550-6606.

Kojima F, Kapoor M, Kawai S, Yang L, Aronoff DM, Crofford LJ. Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA. Prostaglandins Other Lipid Mediat [print-electronic]. 2009 Jun; 89(1-2): 26-33. PMID: 19464664, PMCID: PMC2738595, PII: S1098-8823(09)00018-5, DOI: 10.1016/j.prostaglandins.2009.03.001, ISSN: 1098-8823.

Machado ER, Carlos D, Lourenço EV, Sorgi CA, Silva EV, Ramos SG, Ueta MT, Aronoff DM, Faccioli LH. Counterregulation of Th2 immunity by interleukin 12 reduces host defenses against Strongyloides venezuelensis infection. Microbes Infect [print-electronic]. 2009 Apr; 11(5): 571-8. PMID: 19344783, PII: S1286-4579(09)00059-8, DOI: 10.1016/j.micinf.2009.03.005, ISSN: 1769-714X.

Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M. Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. J. Immunol. 2008 Oct 10/15/2008; 181(8): 5501-9. PMID: 18832707, PMCID: PMC3077557, PII: 181/8/5501, ISSN: 1550-6606.

Malani AN, Aronoff DM. Voriconazole-induced photosensitivity. Clin Med Res [print-electronic]. 2008 Sep; 6(2): 83-5. PMID: 18801950, PMCID: PMC2572550, PII: cmr.2008.806, DOI: 10.3121/cmr.2008.806, ISSN: 1554-6179.

Gandhi T, Wu AH, Aronoff DM. Severe transient cardiomyopathy associated with community-acquired pneumonia caused by Streptococcus pneumoniae. Heart Lung. 2008 Sep; 37(5): 394-7. PMID: 18790341, PII: S0147-9563(07)00173-2, DOI: 10.1016/j.hrtlng.2007.07.003, ISSN: 1527-3288.

Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M. Cyclic AMP: master regulator of innate immune cell function. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2008 Aug; 39(2): 127-32. PMID: 18323530, PMCID: PMC2720142, PII: 2008-0091TR, DOI: 10.1165/rcmb.2008-0091TR, ISSN: 1535-4989.

Aronoff DM, Hao Y, Chung J, Coleman N, Lewis C, Peres CM, Serezani CH, Chen GH, Flamand N, Brock TG, Peters-Golden M. Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii. J. Immunol. 2008 Jun 6/15/2008; 180(12): 8222-30. PMID: 18523288, PMCID: PMC2667109, PII: 180/12/8222, ISSN: 0022-1767.

Brock TG, Serezani CH, Carstens JK, Peters-Golden M, Aronoff DM. Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages. Exp. Cell Res [print-electronic]. 2008 Jan 1/15/2008; 314(2): 255-63. PMID: 18021770, PMCID: PMC2390918, PII: S0014-4827(07)00491-0, DOI: 10.1016/j.yexcr.2007.10.011, ISSN: 0014-4827.

Aronoff DM, Mulla ZD. Postpartum invasive group A streptococcal disease in the modern era. Infect Dis Obstet Gynecol [print-electronic]. 2008; 2008: 796892. PMID: 19125207, PMCID: PMC2612756, DOI: 10.1155/2008/796892, ISSN: 1098-0997.

Canetti C, Serezani CH, Atrasz RG, White ES, Aronoff DM, Peters-Golden M. Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages. J. Immunol. 2007 Dec 12/15/2007; 179(12): 8350-6. PMID: 18056380, PII: 179/12/8350, ISSN: 0022-1767.

Aronoff DM, Mulla ZD. Comments regarding "pain and a purple lesion" [letter]. Am. J. Med. 2007 Nov; 120(11): e15; author reply e17. PMID: 17976397, PII: S0002-9343(06)01414-8, DOI: 10.1016/j.amjmed.2006.11.022, ISSN: 1555-7162.

Hsu A, Aronoff DM, Phipps J, Goel D, Mancuso P. Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clin. Exp. Immunol [print-electronic]. 2007 Nov; 150(2): 332-9. PMID: 17822444, PMCID: PMC2219341, PII: CEI3491, DOI: 10.1111/j.1365-2249.2007.03491.x, ISSN: 1365-2249.

Nuwayhid ZB, Aronoff DM, Mulla ZD. Blunt trauma as a risk factor for group A streptococcal necrotizing fasciitis. Ann Epidemiol [print-electronic]. 2007 Nov; 17(11): 878-81. PMID: 17697787, PMCID: PMC4029051, PII: S1047-2797(07)00214-1, DOI: 10.1016/j.annepidem.2007.05.011, ISSN: 1047-2797.

Serezani CH, Chung J, Ballinger MN, Moore BB, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2007 Nov; 37(5): 562-70. PMID: 17585108, PMCID: PMC2048683, PII: 2007-0153OC, DOI: 10.1165/rcmb.2007-0153OC, ISSN: 1535-4989.

Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J. Immunol. 2007 Oct 10/15/2007; 179(8): 5454-61. PMID: 17911632, PII: 179/8/5454, ISSN: 0022-1767.

Frantz FG, Rosada RS, Turato WM, Peres CM, Coelho-Castelo AA, Ramos SG, Aronoff DM, Silva CL, Faccioli LH. The immune response to toxocariasis does not modify susceptibility to Mycobacterium tuberculosis infection in BALB/c mice. Am. J. Trop. Med. Hyg. 2007 Oct; 77(4): 691-8. PMID: 17978073, PII: 77/4/691, ISSN: 0002-9637.

Mulla ZD, Gibbs SG, Aronoff DM. Correlates of length of stay, cost of care, and mortality among patients hospitalized for necrotizing fasciitis. Epidemiol. Infect [print-electronic]. 2007 Jul; 135(5): 868-76. PMID: 17083749, PMCID: PMC2870628, PII: S0950268806007448, DOI: 10.1017/S0950268806007448, ISSN: 0950-2688.

Aronoff DM, Peres CM, Serezani CH, Ballinger MN, Carstens JK, Coleman N, Moore BB, Peebles RS, Faccioli LH, Peters-Golden M. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities. J. Immunol. 2007 Feb 2/1/2007; 178(3): 1628-34. PMID: 17237412, PII: 178/3/1628, ISSN: 0022-1767.

Huang S, Wettlaufer SH, Hogaboam C, Aronoff DM, Peters-Golden M. Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2007 Feb; 292(2): L405-13. PMID: 17028262, PII: 00232.2006, DOI: 10.1152/ajplung.00232.2006, ISSN: 1040-0605.

Aronoff DM, Serezani CH, Carstens JK, Marshall T, Gangireddy SR, Peters-Golden M, Reddy RC. Stimulatory Effects of Peroxisome Proliferator-Activated Receptor-gamma on Fcgamma Receptor-Mediated Phagocytosis by Alveolar Macrophages. PPAR Res. 2007; 2007: 52546. PMID: 18253476, PMCID: PMC2220046, DOI: 10.1155/2007/52546, ISSN: 1687-4757.

Aronoff DM, Romanovsky AA. Eicosanoids in non-febrile thermoregulation. Prog. Brain Res. 2007; 162: 15-25. PMID: 17645912, PII: S0079-6123(06)62002-5, DOI: 10.1016/S0079-6123(06)62002-5, ISSN: 0079-6123.

Aronoff DM. Losing by a nose: diagnostic and therapeutic challenges of the trigeminal trophic syndrome [editorial]. South. Med. J. 2007 Jan; 100(1): 3. PMID: 17269515, DOI: 10.1097/SMJ.0b013e31802f84ce, ISSN: 0038-4348.

Aronoff DM, Carstens JK, Chen GH, Toews GB, Peters-Golden M. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J. Interferon Cytokine Res. 2006 Nov; 26(11): 827-33. PMID: 17115901, DOI: 10.1089/jir.2006.26.827, ISSN: 1079-9907.

Ballinger MN, Aronoff DM, McMillan TR, Cooke KR, Olkiewicz K, Toews GB, Peters-Golden M, Moore BB. Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J. Immunol. 2006 Oct 10/15/2006; 177(8): 5499-508. PMID: 17015736, PII: 177/8/5499, ISSN: 0022-1767.

Malani AN, Aronoff DM, Bradley SF, Kauffman CA. Cardiobacterium hominis endocarditis: Two cases and a review of the literature. Eur. J. Clin. Microbiol. Infect. Dis. 2006 Sep; 25(9): 587-95. PMID: 16955250, PMCID: PMC2276845, DOI: 10.1007/s10096-006-0189-9, ISSN: 0934-9723.

Aronoff DM, Mulla ZD. Nonsteroidal antiinflammatory drugs and group A streptococcal infection [letter]. Emerging Infect. Dis. 2006 Aug; 12(8): 1291. PMID: 16972353, PMCID: PMC3291206, DOI: 10.3201/eid1208.051067, ISSN: 1080-6040.

Canetti C, Aronoff DM, Choe M, Flamand N, Wettlaufer S, Toews GB, Chen GH, Peters-Golden M. Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages. J. Leukoc. Biol [print-electronic]. 2006 Jun; 79(6): 1234-41. PMID: 16574771, PII: jlb.0705374, DOI: 10.1189/jlb.0705374, ISSN: 0741-5400.

Ballinger MN, Paine R, Serezani CH, Aronoff DM, Choi ES, Standiford TJ, Toews GB, Moore BB. Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Jun; 34(6): 766-74. PMID: 16474098, PMCID: PMC2644237, PII: 2005-0246OC, DOI: 10.1165/rcmb.2005-0246OC, ISSN: 1044-1549.

Young MH, Engleberg NC, Mulla ZD, Aronoff DM. Therapies for necrotising fasciitis. Expert Opin Biol Ther. 2006 Feb; 6(2): 155-65. PMID: 16436041, DOI: 10.1517/14712598.6.2.155, ISSN: 1744-7682.

Aronoff DM, Oates JA, Boutaud O. New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Clin. Pharmacol. Ther. 2006 Jan; 79(1): 9-19. PMID: 16413237, PII: S0009-9236(05)00429-7, DOI: 10.1016/j.clpt.2005.09.009, ISSN: 0009-9236.

Luo M, Jones SM, Flamand N, Aronoff DM, Peters-Golden M, Brock TG. Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase. J. Biol. Chem [print-electronic]. 2005 Dec 12/9/2005; 280(49): 40609-16. PMID: 16230355, PII: M507045200, DOI: 10.1074/jbc.M507045200, ISSN: 0021-9258.

Serezani CH, Aronoff DM, Jancar S, Peters-Golden M. Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. J. Leukoc. Biol [print-electronic]. 2005 Oct; 78(4): 976-84. PMID: 16006535, PII: jlb.1004587, DOI: 10.1189/jlb.1004587, ISSN: 0741-5400.

Romanovsky AA, Almeida MC, Aronoff DM, Ivanov AI, Konsman JP, Steiner AA, Turek VF. Fever and hypothermia in systemic inflammation: recent discoveries and revisions. Front. Biosci. 2005 Sep 9/1/2005; 10: 2193-216. PMID: 15970487, PII: 1690, ISSN: 1093-9946.

Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M. Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood [print-electronic]. 2005 Aug 8/1/2005; 106(3): 1067-75. PMID: 15718414, PMCID: PMC1895163, PII: 2004-08-3323, DOI: 10.1182/blood-2004-08-3323, ISSN: 0006-4971.

Young MH, Aronoff DM, Engleberg NC. Necrotizing fasciitis: pathogenesis and treatment. Expert Rev Anti Infect Ther. 2005 Apr; 3(2): 279-94. PMID: 15918785, DOI: 10.1586/14787210.3.2.279, ISSN: 1744-8336.

White ES, Atrasz RG, Dickie EG, Aronoff DM, Stambolic V, Mak TW, Moore BB, Peters-Golden M. Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2005 Feb; 32(2): 135-41. PMID: 15539459, PMCID: PMC1965457, PII: 2004-0126OC, DOI: 10.1165/rcmb.2004-0126OC, ISSN: 1044-1549.

Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M. Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J. Immunol. 2005 Jan 1/15/2005; 174(2): 595-9. PMID: 15634874, PII: 174/2/595, ISSN: 0022-1767.

Aronoff DM, Canetti C, Peters-Golden M. Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J. Immunol. 2004 Jul 7/1/2004; 173(1): 559-65. PMID: 15210817, ISSN: 0022-1767.

Monrad SU, Terrell JE, Aronoff DM. The trigeminal trophic syndrome: an unusual cause of nasal ulceration. J. Am. Acad. Dermatol. 2004 Jun; 50(6): 949-52. PMID: 15153901, PII: S0190962204005031, DOI: 10.1016/j.jaad.2004.01.038, ISSN: 0190-9622.

Alonto AM, Aronoff DM, Malani PN. West Nile virus meningitis in patient with common variable immunodeficiency. Emerging Infect. Dis. 2003 Oct; 9(10): 1353-4. PMID: 14626226, PMCID: PMC3033085, DOI: 10.3201/eid0910.030195, ISSN: 1080-6040.

Kozak W, Aronoff DM, Boutaud O, Kozak A. 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide. Exp. Biol. Med. (Maywood). 2003 Jul; 228(7): 786-94. PMID: 12876297, ISSN: 1535-3702.

Aronoff DM, Bloch KC. Assessing the relationship between the use of nonsteroidal antiinflammatory drugs and necrotizing fasciitis caused by group A streptococcus. Medicine (Baltimore). 2003 Jul; 82(4): 225-35. PMID: 12861100, DOI: 10.1097/01.md.0000085060.63483.bb, ISSN: 0025-7974.

Aronoff DM, Watt G. Prevalence of relative bradycardia in Orientia tsutsugamushi infection. Am. J. Trop. Med. Hyg. 2003 Apr; 68(4): 477-9. PMID: 12875300, ISSN: 0002-9637.

Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J. Pharmacol. Exp. Ther. 2003 Feb; 304(2): 589-95. PMID: 12538810, DOI: 10.1124/jpet.102.042853, ISSN: 0022-3565.

Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. Adv. Exp. Med. Biol. 2003; 525: 125-8. PMID: 12751750, ISSN: 0065-2598.

Aronoff DM. Using live pathogens to treat infectious diseases: a historical perspective on the relationship between GB virus C and HIV. Antivir. Ther. (Lond.). 2002 Jun; 7(2): 73-80. PMID: 12212927, ISSN: 1359-6535.

Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc. Natl. Acad. Sci. U.S.A. 2002 May 5/14/2002; 99(10): 7130-5. PMID: 12011469, PMCID: PMC124540, PII: 99/10/7130, DOI: 10.1073/pnas.102588199, ISSN: 0027-8424.

Aronoff DM. Comments to the editor concerning the paper entitled "Orexin-A regulates body temperature in coordination with arousal status" by Yoshimichi et al. Exp. Biol. Med. (Maywood). 2002 Jan; 227(1): 1-2; discussion 3. PMID: 11788776, ISSN: 1535-3702.

Aronoff DM. Aspirin and Reye's syndrome: discovery of aspirin and paracetamol [letter]. Drug Saf. 2002; 25(10): 751. PMID: 12167070, PII: 251007, DOI: 10.2165/00002018-200225100-00007, ISSN: 0114-5916.

Aronoff DM, Neilson EG. Antipyretics: mechanisms of action and clinical use in fever suppression. Am. J. Med. 2001 Sep; 111(4): 304-15. PMID: 11566461, PII: S0002-9343(01)00834-8, ISSN: 0002-9343.

Slifer A, Aronoff DM. Bilateral adrenal cortical hyperplasia. Tenn Med. 2000 May; 93(5): 172-3. PMID: 10821072, ISSN: 1088-6222.

Williams SJ, Aronoff DM. Vanderbilt Morning Report. A young woman with gastrointestinal bleeding. Tenn Med. 2000 Mar; 93(3): 103-5. PMID: 10714187, ISSN: 1088-6222.

Aronoff DM, Morgan HJ. A patient with an acute viral syndrome. Tenn Med. 2000 Feb; 93(2): 64-5. PMID: 10668371, ISSN: 1088-6222.

Shedd OL, Hamilton K, Aronoff DM. A 30-year-old woman with disseminated histoplasmosis. Tenn Med. 1999 Nov; 92(11): 420-1. PMID: 10548927, ISSN: 1088-6222.

Aronoff DM, Roshon M. Severe hemorrhage complicating the Klippel-Trénaunay-Weber syndrome. South. Med. J. 1998 Nov; 91(11): 1073-5. PMID: 9824196, ISSN: 0038-4348.

Aronoff DM, Callen JP. Necrosing livedo reticularis in a patient with recurrent pulmonary hemorrhage. J. Am. Acad. Dermatol. 1997 Aug; 37(2 Pt 2): 300-2. PMID: 9270531, PII: S0190-9622(97)80375-1, ISSN: 0190-9622.

Available Postdoctoral Position Details
Posted: 6/13/2018

Postdoctoral Research Fellowship Available

Clostridium difficile Host-Microbe Interactions & Translational Research Fellowship 

Where: The Aronoff Lab, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Start date: immediately

The Aronoff Lab in the Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, is seeking candidates for a Postdoctoral Research Fellowship in Infectious Diseases to join a team studying clinical and translational aspects of Clostridium difficile infection. Our lab focuses on host-microbial interactions in the context of serious Gram positive bacterial infections.

Training opportunities will be related to: animal models of C. difficile infection, clinical pharmacology, mucosal immunology and microbiology as well as building experience in the conduct of large human clinical trial.

Job requirements will include working with human research subjects, assisting with some mouse handling and infection and conducting bench-top assays related to bacterial pathogenesis and immune responses.

The appropriate candidate will have a PhD or MD (or both) and experience in bacterial pathogenesis and/or intestinal mucosal immunology. Preference will be given to individuals with experience in clostridial microbiology or host-microbe interactions. Strong organizational skills are a must. Candidates must be self-motivated, able to write scientific manuscripts and proposals well and have a track record of strong productivity. Postdoctoral fellows will be expected to be able to function well in team science and in mentoring graduate students.

The Vanderbilt University Medical Center is an equal opportunities employer.

Interested applicants are requested to mail their CV, a one-page personal statement, and two letters of recommendation with reference phone numbers and email addresses to: David M. Aronoff, MD, d.aronoff@vanderbilt.edu