Haichun Yang, M.D., Ph.D.

Research Instructor

haichun.yang@vanderbilt.edu
Faculty Appointments
Research Instructor in Pathology, Microbiology and Immunology Research Instructor in Pediatrics
Education
Ph.D., Fudan University, Shanghai, ChinaM.D., Shanghai Medical University, Shanghai, ChinaB.S., Shanghai Medical University, Shanghai, China
Office Address
C-3322 MCN
CT 2561
Publications
Skrypnyk NI, Voziyan P, Yang H, de Caestecker CR, Theberge MC, Drouin M, Hudson B, Harris RC, de Caestecker MP. Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2016 Aug 8/1/2016; 311(2): F268-77. PMID: 27194713, PMCID: PMC5008672, PII: ajprenal.00056.2016, DOI: 10.1152/ajprenal.00056.2016, ISSN: 1522-1466.

Matsushita K, Yang HC, Mysore MM, Zhong J, Shyr Y, Ma LJ, Fogo AB. Effects of combination PPAR¿ agonist and angiotensin receptor blocker on glomerulosclerosis. Lab. Invest [print-electronic]. 2016 Jun; 96(6): 602-9. PMID: 26999660, PII: labinvest201642, DOI: 10.1038/labinvest.2016.42, ISSN: 1530-0307.

Yang H, Fogo AB, Kon V. Kidneys: key modulators of high-density lipoprotein levels and function. Curr. Opin. Nephrol. Hypertens. 2016 May; 25(3): 174-9. PMID: 27008596, PMCID: PMC4899840, DOI: 10.1097/MNH.0000000000000217, ISSN: 1473-6543.

Chiba T, Skrypnyk NI, Skvarca LB, Penchev R, Zhang KX, Rochon ER, Fall JL, Paueksakon P, Yang H, Alford CE, Roman BL, Zhang MZ, Harris R, Hukriede NA, de Caestecker MP. Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI. J. Am. Soc. Nephrol [print-electronic]. 2016 Feb; 27(2): 495-508. PMID: 26109319, PMCID: PMC4731115, PII: ASN.2014111108, DOI: 10.1681/ASN.2014111108, ISSN: 1533-3450.

Qian HS, Weldon SM, Matera D, Lee C, Yang H, Fryer RM, Fogo AB, Reinhart GA. Quantification and Comparison of Anti-Fibrotic Therapies by Polarized SRM and SHG-Based Morphometry in Rat UUO Model. PLoS ONE. 2016; 11(6): e0156734. PMID: 27257917, PMCID: PMC4892485, PII: PONE-D-15-48960, DOI: 10.1371/journal.pone.0156734, ISSN: 1932-6203.

Yamamoto S, Zhong J, Yancey PG, Zuo Y, Linton MF, Fazio S, Yang H, Narita I, Kon V. Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. Atherosclerosis [print-electronic]. 2015 Sep; 242(1): 56-64. PMID: 26184694, PMCID: PMC4850906, PII: S0021-9150(15)30016-2, DOI: 10.1016/j.atherosclerosis.2015.06.055, ISSN: 1879-1484.

Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L. Renal fibrosis is not reduced by blocking transforming growth factor-ß signaling in matrix-producing interstitial cells. Kidney Int [print-electronic]. 2015 Sep; 88(3): 503-14. PMID: 25760325, PMCID: PMC4556568, PII: S2157-1716(15)32233-4, DOI: 10.1038/ki.2015.51, ISSN: 1523-1755.

Kon V, Yang H, Fazio S. Residual Cardiovascular Risk in Chronic Kidney Disease: Role of High-density Lipoprotein. Arch. Med. Res [print-electronic]. 2015 Jul; 46(5): 379-91. PMID: 26009251, PMCID: PMC4805367, PII: S0188-4409(15)00129-0, DOI: 10.1016/j.arcmed.2015.05.009, ISSN: 1873-5487.

Yang HC, Fogo AB. Fibrosis and renal aging. Kidney Int Suppl (2011). 2014 Nov; 4(1): 75-8. PMID: 26312154, PMCID: PMC4536965, PII: S2157-1716(15)31196-5, DOI: 10.1038/kisup.2014.14, ISSN: 2157-1724.

Yang HC, Fogo AB. Mechanisms of disease reversal in focal and segmental glomerulosclerosis. Adv Chronic Kidney Dis. 2014 Sep; 21(5): 442-7. PMID: 25168834, PMCID: PMC4151242, PII: S1548-5595(14)00076-7, DOI: 10.1053/j.ackd.2014.04.001, ISSN: 1548-5609.

Zhong J, Yang HC, Kon V, Fogo AB, Lawrence DA, Ma J. Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts. Lab. Invest [print-electronic]. 2014 Jun; 94(6): 633-44. PMID: 24687120, PMCID: PMC4361016, PII: labinvest201451, DOI: 10.1038/labinvest.2014.51, ISSN: 1530-0307.

Lim BJ, Yang HC, Fogo AB. Animal models of regression/progression of kidney disease. Drug Discov Today Dis Models. 2014; 11: 45-51. PMID: 25722733, PMCID: PMC4337226, DOI: 10.1016/j.ddmod.2014.06.003, ISSN: 1740-6757.

Yang HC, Liu SJ, Fogo AB. Kidney regeneration in mammals. Nephron Exp. Nephrol [print-electronic]. 2014; 126(2): 50. PMID: 24854640, PMCID: PMC4337834, PII: 000360661, DOI: 10.1159/000360661, ISSN: 1660-2129.

Miyazawa T, Zeng F, Wang S, Fan X, Cheng H, Yang H, Bian A, Fogo AB, Harris RC. Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression. Kidney Int [print-electronic]. 2013 Dec; 84(6): 1176-88. PMID: 23760291, PMCID: PMC3796048, PII: S0085-2538(15)56105-X, DOI: 10.1038/ki.2013.214, ISSN: 1523-1755.

Zuo Y, Chun B, Potthoff SA, Kazi N, Brolin TJ, Orhan D, Yang HC, Ma LJ, Kon V, Myöhänen T, Rhaleb NE, Carretero OA, Fogo AB. Thymosin ß4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis. Kidney Int [print-electronic]. 2013 Dec; 84(6): 1166-75. PMID: 23739235, PMCID: PMC3830708, PII: S0085-2538(15)56103-6, DOI: 10.1038/ki.2013.209, ISSN: 1523-1755.

Fatima H, Moeller MJ, Smeets B, Yang HC, D'Agati VD, Alpers CE, Fogo AB. Parietal epithelial cell activation marker in early recurrence of FSGS in the transplant. Clin J Am Soc Nephrol [print-electronic]. 2012 Nov; 7(11): 1852-8. PMID: 22917699, PMCID: PMC3488951, PII: CJN.10571011, DOI: 10.2215/CJN.10571011, ISSN: 1555-905X.

Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R. Specific deletion of glycogen synthase kinase-3ß in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney Int [print-electronic]. 2012 Nov; 82(9): 1000-9. PMID: 22785175, PMCID: PMC3472082, PII: S0085-2538(15)55668-8, DOI: 10.1038/ki.2012.239, ISSN: 1523-1755.

Zhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC. Intrarenal dopamine inhibits progression of diabetic nephropathy. Diabetes [print-electronic]. 2012 Oct; 61(10): 2575-84. PMID: 22688335, PMCID: PMC3447896, PII: db12-0046, DOI: 10.2337/db12-0046, ISSN: 1939-327X.

Zuo Y, Yang HC, Potthoff SA, Najafian B, Kon V, Ma LJ, Fogo AB. Protective effects of PPAR¿ agonist in acute nephrotic syndrome. Nephrol. Dial. Transplant [print-electronic]. 2012 Jan; 27(1): 174-81. PMID: 21565943, PMCID: PMC3276311, PII: gfr240, DOI: 10.1093/ndt/gfr240, ISSN: 1460-2385.

Yang HC, Rossini M, Ma LJ, Zuo Y, Ma J, Fogo AB. Cells derived from young bone marrow alleviate renal aging. J. Am. Soc. Nephrol [print-electronic]. 2011 Nov; 22(11): 2028-36. PMID: 21965376, PMCID: PMC3231782, PII: ASN.2010090982, DOI: 10.1681/ASN.2010090982, ISSN: 1533-3450.

Zhang MZ, Yao B, Wang S, Fan X, Wu G, Yang H, Yin H, Yang S, Harris RC. Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J. Clin. Invest [print-electronic]. 2011 Jul; 121(7): 2845-54. PMID: 21701066, PMCID: PMC3223841, PII: 57324, DOI: 10.1172/JCI57324, ISSN: 1558-8238.

Ma J, Matsusaka T, Yang HC, Zhong J, Takagi N, Fogo AB, Kon V, Ichikawa I. Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside. Pediatr. Res. 2011 Jul; 70(1): 83-9. PMID: 21451433, PMCID: PMC3113658, DOI: 10.1203/PDR.0b013e31821bdf1c, ISSN: 1530-0447.

Ma LJ, Corsa BA, Zhou J, Yang H, Li H, Tang YW, Babaev VR, Major AS, Linton MF, Fazio S, Hunley TE, Kon V, Fogo AB. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Am. J. Physiol. Renal Physiol [print-electronic]. 2011 May; 300(5): F1203-13. PMID: 21367915, PMCID: PMC3094053, PII: ajprenal.00468.2010, DOI: 10.1152/ajprenal.00468.2010, ISSN: 1522-1466.

Yang H, Fogo AB. Cell senescence in the aging kidney. J. Am. Soc. Nephrol [print-electronic]. 2010 Sep; 21(9): 1436-9. PMID: 20705707, PII: ASN.2010020205, DOI: 10.1681/ASN.2010020205, ISSN: 1533-3450.

Rossini M, Naito T, Yang H, Freeman M, Donnert E, Ma LJ, Dunn SR, Sharma K, Fogo AB. Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Nephrol. Dial. Transplant [print-electronic]. 2010 Jun; 25(6): 1803-10. PMID: 20061322, PMCID: PMC2902889, PII: gfp724, DOI: 10.1093/ndt/gfp724, ISSN: 1460-2385.

He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J. Clin. Invest [print-electronic]. 2010 Apr; 120(4): 1056-68. PMID: 20335659, PMCID: PMC2846063, PII: 41563, DOI: 10.1172/JCI41563, ISSN: 1558-8238.

Naito T, Ma LJ, Yang H, Zuo Y, Tang Y, Han JY, Kon V, Fogo AB. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Am. J. Physiol. Renal Physiol [print-electronic]. 2010 Mar; 298(3): F683-91. PMID: 20042458, PMCID: PMC2838584, PII: 00503.2009, DOI: 10.1152/ajprenal.00503.2009, ISSN: 1522-1466.

Yang HC, Zuo Y, Fogo AB. Models of chronic kidney disease. Drug Discov Today Dis Models. 2010; 7(1-2): 13-9. PMID: 21286234, PMCID: PMC3030258, DOI: 10.1016/j.ddmod.2010.08.002, ISSN: 1740-6757.

Giannico G, Yang H, Neilson EG, Fogo AB. Dystroglycan in the diagnosis of FSGS. Clin J Am Soc Nephrol [print-electronic]. 2009 Nov; 4(11): 1747-53. PMID: 19808230, PMCID: PMC2774958, PII: CJN.01510209, DOI: 10.2215/CJN.01510209, ISSN: 1555-905X.

Yang HC, Deleuze S, Zuo Y, Potthoff SA, Ma LJ, Fogo AB. The PPARgamma agonist pioglitazone ameliorates aging-related progressive renal injury. J. Am. Soc. Nephrol [print-electronic]. 2009 Nov; 20(11): 2380-8. PMID: 19797472, PMCID: PMC2799181, PII: ASN.2008111138, DOI: 10.1681/ASN.2008111138, ISSN: 1533-3450.

Ma J, Rossini M, Yang HC, Zuo Y, Fogo AB, Ichikawa I. Effects of podocyte injury on glomerular development. Pediatr. Res. 2007 Oct; 62(4): 417-21. PMID: 17667850, PII: 00006450-200710000-00007, DOI: 10.1203/PDR.0b013e31813cbed1, ISSN: 0031-3998.

Yang HC, Ma LJ, Ma J, Fogo AB. Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. Kidney Int. 2006 May; 69(10): 1756-64. PMID: 16598202, PII: S0085-2538(15)51354-9, DOI: 10.1038/sj.ki.5000336, ISSN: 0085-2538.

Ma LJ, Nakamura S, Aldigier JC, Rossini M, Yang H, Liang X, Nakamura I, Marcantoni C, Fogo AB. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J. Am. Soc. Nephrol [print-electronic]. 2005 Apr; 16(4): 966-76. PMID: 15728787, PII: ASN.2004060492, DOI: 10.1681/ASN.2004060492, ISSN: 1046-6673.

Ma J, Matsusaka T, Yang H, Kawachi H, Shimizu F, Isaka Y, Imai E, Kon V, Ichikawa I. Local actions of endogenous angiotensin II in injured glomeruli. J. Am. Soc. Nephrol. 2004 May; 15(5): 1268-76. PMID: 15100367, ISSN: 1046-6673.

Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am. J. Pathol. 2003 Oct; 163(4): 1261-73. PMID: 14507636, PMCID: PMC1868298, PII: S0002-9440(10)63486-4, ISSN: 0002-9440.