R. Stokes Peebles, M.D.



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Faculty Appointments
Professor of Medicine Elizabeth and John Murray Chair in MedicineProfessor of Pathology, Microbiology and Immunology
M.D., Medicine , Vanderbilt University, Nashville, TennesseeB.S., Davidson College, Davidson, North Carolina
Office Address
T-1218 MCN
Vanderbilt University Medical Center
1161 21st Avenue South
Nashville, TN 37232-2650
Research Description
Our lab is interested in allergically-mediated and virally-induced lung inflammation. Presently funded projects include how prostaglandin I2 and glucagon-like peptide 1 receptor agonists mediate inflammatory responses.
Research Keywords
asthma, allergy, lung, inflammation, respiratory virus
Rusznak M, Peebles RS. Prostaglandin E2 in NSAID-exacerbated respiratory disease: protection against cysteinyl leukotrienes and group 2 innate lymphoid cells. Curr Opin Allergy Clin Immunol. 2019 Feb; 19(1): 38-45. PMID: 30516547, PMCID: PMC6296891, DOI: 10.1097/ACI.0000000000000498, ISSN: 1473-6322.

Peebles RS. Prostaglandins in asthma and allergic diseases. Pharmacol. Ther [print-electronic]. 2019 Jan; 193: 1-19. PMID: 30081047, PMCID: PMC6309751, PII: S0163-7258(18)30133-5, DOI: 10.1016/j.pharmthera.2018.08.001, ISSN: 1879-016X.

Rusznak M, Peebles RS. Eosinophils Express LTA4 Hydrolase and Synthesize LTB4; Important for Asthma Pathogenesis?. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2018 Nov 11/15/2018; PMID: 30433812, DOI: 10.1165/rcmb.2018-0367ED, ISSN: 1535-4989.

Tashkin DP, Peebles RS. Controversies in Allergy: Is Asthma Chronic Obstructive Pulmonary Disease Overlap a Distinct Syndrome That Changes Treatment and Patient Outcomes?. J Allergy Clin Immunol Pract [print-electronic]. 2018 Nov 11/14/2018; PMID: 30448110, PII: S2213-2198(18)30695-0, DOI: 10.1016/j.jaip.2018.10.024, ISSN: 2213-2201.

Toki S, Goleniewska K, Reiss S, Zhang J, Bloodworth MH, Stier MT, Zhou W, Newcomb DC, Ware LB, Stanwood GD, Galli A, Boyd KL, Niswender KD, Peebles RS. Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo. J. Allergy Clin. Immunol [print-electronic]. 2018 Nov; 142(5): 1515-1528.e8. PMID: 29331643, PII: S0091-6749(18)30027-7, DOI: 10.1016/j.jaci.2017.11.043, ISSN: 1097-6825.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Gebretsadik T, Halpin RA, Nelson KE, Moore ML, Anderson LJ, Peebles RS, Das SR, Hartert TV. Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy. J. Allergy Clin. Immunol [print-electronic]. 2018 Nov; 142(5): 1447-1456.e9. PMID: 29330010, PMCID: PMC6039278, PII: S0091-6749(18)30031-9, DOI: 10.1016/j.jaci.2017.10.049, ISSN: 1097-6825.

Stier MT, Peebles RS. Host and Viral Determinants of Respiratory Syncytial Virus-induced Airway Mucus. Ann Am Thorac Soc. 2018 Nov; 15(Supplement_3): S205-S209. PMID: 30431348, PMCID: PMC6322028, DOI: 10.1513/AnnalsATS.201806-380AW, ISSN: 2325-6621.

Wurth MA, Hadadianpour A, Horvath DJ, Daniel J, Bogdan O, Goleniewska K, Pomés A, Hamilton RG, Peebles RS, Smith SA. Human IgE mAbs define variability in commercial Aspergillus extract allergen composition. JCI Insight [print-electronic]. 2018 Oct 10/18/2018; 3(20): PMID: 30333320, PMCID: PMC6237483, PII: 123387, DOI: 10.1172/jci.insight.123387, ISSN: 2379-3708.

Turi KN, Shankar J, Anderson LJ, Rajan D, Gaston K, Gebretsadik T, Das SR, Stone C, Larkin EK, Rosas-Salazar C, Brunwasser SM, Moore ML, Peebles RS, Hartert TV. Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze. Am. J. Respir. Crit. Care Med. 2018 Oct 10/15/2018; 198(8): 1064-73. PMID: 29733679, PMCID: PMC6221572, DOI: 10.1164/rccm.201711-2348OC, ISSN: 1535-4970.

Fuseini H, Yung JA, Cephus JY, Zhang J, Goleniewska K, Polosukhin VV, Peebles RS, Newcomb DC. Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation. J. Immunol [print-electronic]. 2018 Oct 10/1/2018; 201(7): 1843-54. PMID: 30127088, PMCID: PMC6143420, PII: jimmunol.1800293, DOI: 10.4049/jimmunol.1800293, ISSN: 1550-6606.

Zhou W, Zhang J, Toki S, Goleniewska K, Johnson MO, Bloodworth MH, Newcomb DC, Peebles RS. The PGI2 Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells. J. Immunol [print-electronic]. 2018 Oct 10/1/2018; 201(7): 1936-45. PMID: 30127087, PMCID: PMC6162094, PII: jimmunol.1700605, DOI: 10.4049/jimmunol.1700605, ISSN: 1550-6606.

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP. PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-ß1 production. Sci Transl Med. 2018 Sep 9/26/2018; 10(460): PMID: 30257954, PMCID: PMC6263177, PII: 10/460/eaar8356, DOI: 10.1126/scitranslmed.aar8356, ISSN: 1946-6242.

Bloodworth MH, Rusznak M, Bastarache L, Wang J, Denny JC, Peebles RS. Association of ST2 polymorphisms with atopy, asthma, and leukemia. J. Allergy Clin. Immunol [print-electronic]. 2018 Sep; 142(3): 991-993.e3. PMID: 29787780, PMCID: PMC6129405, PII: S0091-6749(18)30712-7, DOI: 10.1016/j.jaci.2018.03.020, ISSN: 1097-6825.

Ke Z, Dillard RS, Chirkova T, Leon F, Stobart CC, Hampton CM, Strauss JD, Rajan D, Rostad CA, Taylor JV, Yi H, Shah R, Jin M, Hartert TV, Peebles RS, Graham BS, Moore ML, Anderson LJ, Wright ER. The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography. Viruses. 2018 Aug 8/20/2018; 10(8): PMID: 30127286, PMCID: PMC6116276, PII: v10080446, DOI: 10.3390/v10080446, ISSN: 1999-4915.

Bloodworth MH, Rusznak M, Pfister CC, Zhang J, Bastarache L, Calvillo SA, Chappell JD, Boyd KL, Toki S, Newcomb DC, Stier MT, Zhou W, Goleniewska K, Moore ML, Hartert TV, Niswender KD, Peebles RS. Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology. J. Allergy Clin. Immunol [print-electronic]. 2018 Aug; 142(2): 683-687.e12. PMID: 29678751, PMCID: PMC6078807, PII: S0091-6749(18)30561-X, DOI: 10.1016/j.jaci.2018.01.053, ISSN: 1097-6825.

Stone CA, Hemler JA, Commins SP, Schuyler AJ, Phillips EJ, Peebles RS, Fahrenholz JM. Reply [letter]. J. Allergy Clin. Immunol [print-electronic]. 2018 May; 141(5): 1957-8. PMID: 29370925, PMCID: PMC6298749, PII: S0091-6749(17)31891-2, DOI: 10.1016/j.jaci.2017.08.048, ISSN: 1097-6825.

Toki S, Zhou W, Goleniewska K, Reiss S, Dulek DE, Newcomb DC, Lawson WE, Peebles RS. Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model. Prostaglandins Other Lipid Mediat [print-electronic]. 2018 May; 136: 33-43. PMID: 29660395, PMCID: PMC5970997, PII: S1098-8823(17)30116-8, DOI: 10.1016/j.prostaglandins.2018.04.001, ISSN: 1098-8823.

Stier MT, Zhang J, Goleniewska K, Cephus JY, Rusznak M, Wu L, Van Kaer L, Zhou B, Newcomb DC, Peebles RS. IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow. J. Exp. Med [print-electronic]. 2018 Jan 1/2/2018; 215(1): 263-81. PMID: 29222107, PMCID: PMC5748848, PII: jem.20170449, DOI: 10.1084/jem.20170449, ISSN: 1540-9538.

Empey KM, Peebles RS, Janssen WJ. Mouse Models of Viral Infection. Methods Mol. Biol. 2018; 1809: 395-414. PMID: 29987803, DOI: 10.1007/978-1-4939-8570-8_26, ISSN: 1940-6029.

Rothenberg ME, Saito H, Peebles RS. Advances in mechanisms of allergic disease in 2016. J. Allergy Clin. Immunol [print-electronic]. 2017 Dec; 140(6): 1622-31. PMID: 29038009, PII: S0091-6749(17)31576-2, DOI: 10.1016/j.jaci.2017.08.029, ISSN: 1097-6825.

Stier MT, Peebles RS. Innate lymphoid cells and allergic disease. Ann. Allergy Asthma Immunol. 2017 Dec; 119(6): 480-8. PMID: 29223298, PMCID: PMC5777228, PII: S1081-1206(17)30969-9, DOI: 10.1016/j.anai.2017.08.290, ISSN: 1534-4436.

Cephus JY, Stier MT, Fuseini H, Yung JA, Toki S, Bloodworth MH, Zhou W, Goleniewska K, Zhang J, Garon SL, Hamilton RG, Poloshukin VV, Boyd KL, Peebles RS, Newcomb DC. Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation. Cell Rep. 2017 Nov 11/28/2017; 21(9): 2487-99. PMID: 29186686, PMCID: PMC5731254, PII: S2211-1247(17)31590-5, DOI: 10.1016/j.celrep.2017.10.110, ISSN: 2211-1247.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP. Dietary Manganese Promotes Staphylococcal Infection of the Heart. Cell Host Microbe [print-electronic]. 2017 Oct 10/11/2017; 22(4): 531-542.e8. PMID: 28943329, PMCID: PMC5638708, PII: S1931-3128(17)30342-6, DOI: 10.1016/j.chom.2017.08.009, ISSN: 1934-6069.

Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, Bloodworth MH, Moore ML, Chen K, Kolls JK, Peebles RS. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection. J. Immunol [print-electronic]. 2017 Jul 7/15/2017; 199(2): 510-9. PMID: 28576981, PMCID: PMC5505788, PII: jimmunol.1601984, DOI: 10.4049/jimmunol.1601984, ISSN: 1550-6606.

Peebles RS. Is IL-1ß inhibition the next therapeutic target in asthma? [editorial]. J. Allergy Clin. Immunol [print-electronic]. 2017 Jun; 139(6): 1788-9. PMID: 28396074, PII: S0091-6749(17)30573-0, DOI: 10.1016/j.jaci.2017.03.018, ISSN: 1097-6825.

Stone CA, Hemler JA, Commins SP, Schuyler AJ, Phillips EJ, Peebles RS, Fahrenholz JM. Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism. J. Allergy Clin. Immunol [print-electronic]. 2017 May; 139(5): 1710-1713.e2. PMID: 27986511, PMCID: PMC5420485, PII: S0091-6749(16)31455-5, DOI: 10.1016/j.jaci.2016.10.037, ISSN: 1097-6825.

Hines KL, Peebles RS. Management of the Asthma-COPD Overlap Syndrome (ACOS): a Review of the Evidence. Curr Allergy Asthma Rep. 2017 Mar; 17(3): 15. PMID: 28283854, PII: 10.1007/s11882-017-0683-4, DOI: 10.1007/s11882-017-0683-4, ISSN: 1534-6315.

Petersen CP, Meyer AR, De Salvo C, Choi E, Schlegel C, Petersen A, Engevik AC, Prasad N, Levy SE, Peebles RS, Pizarro TT, Goldenring JR. A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut [print-electronic]. 2017 Feb 2/14/2017; PMID: 28196875, PII: gutjnl-2016-312779, DOI: 10.1136/gutjnl-2016-312779, ISSN: 1468-3288.

Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Shankar J, Yooseph S, Nelson KE, Halpin RA, Moore ML, Anderson LJ, Peebles RS, Das SR, Hartert TV. Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract Infection With Human Rhinovirus and Respiratory Syncytial Virus in Infancy. J. Infect. Dis. 2016 Dec 12/15/2016; 214(12): 1924-8. PMID: 27923952, PMCID: PMC5142087, PII: jiw456, DOI: 10.1093/infdis/jiw456, ISSN: 1537-6613.

Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS. Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation. J. Immunol [print-electronic]. 2016 Sep 9/1/2016; 197(5): 1577-86. PMID: 27456482, PMCID: PMC4992670, PII: jimmunol.1501063, DOI: 10.4049/jimmunol.1501063, ISSN: 1550-6606.

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS, Komalavilas P. Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of ß2-Adrenergic Receptor. Am. J. Respir. Cell Mol. Biol. 2016 Aug; 55(2): 225-33. PMID: 26909644, DOI: 10.1165/rcmb.2015-0139OC, ISSN: 1535-4989.

Toki S, Goleniewska K, Reiss S, Zhou W, Newcomb DC, Bloodworth MH, Stier MT, Boyd KL, Polosukhin VV, Subramaniam S, Peebles RS. The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. Thorax [print-electronic]. 2016 Jul; 71(7): 633-45. PMID: 27071418, PMCID: PMC4941189, PII: thoraxjnl-2015-207728, DOI: 10.1136/thoraxjnl-2015-207728, ISSN: 1468-3296.

Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, Goleniewska K, Kolls JK, Peebles RS. STAT6 Signaling Attenuates Interleukin-17-Producing ¿d T Cells during Acute Klebsiella pneumoniae Infection. Infect. Immun [electronic-print]. 2016 May; 84(5): 1548-55. PMID: 26953325, PMCID: PMC4862712, PII: IAI.00646-15, DOI: 10.1128/IAI.00646-15, ISSN: 1098-5522.

Currier MG, Lee S, Stobart CC, Hotard AL, Villenave R, Meng J, Pretto CD, Shields MD, Nguyen MT, Todd SO, Chi MH, Hammonds J, Krumm SA, Spearman P, Plemper RK, Sakamoto K, Peebles RS, Power UF, Moore ML. EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression. PLoS Pathog. 2016 May; 12(5): e1005622. PMID: 27152417, PMCID: PMC4859522, PII: PPATHOGENS-D-15-02129, DOI: 10.1371/journal.ppat.1005622, ISSN: 1553-7374.

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. J. Allergy Clin. Immunol [print-electronic]. 2016 Apr 4/9/2016; PMID: 27156176, PII: S0091-6749(16)30080-X, DOI: 10.1016/j.jaci.2016.01.050, ISSN: 1097-6825.

Shilts MH, Rosas-Salazar C, Tovchigrechko A, Larkin EK, Torralba M, Akopov A, Halpin R, Peebles RS, Moore ML, Anderson LJ, Nelson KE, Hartert TV, Das SR. Minimally Invasive Sampling Method Identifies Differences in Taxonomic Richness of Nasal Microbiomes in Young Infants Associated with Mode of Delivery. Microb. Ecol [print-electronic]. 2016 Jan; 71(1): 233-42. PMID: 26370110, PMCID: PMC4688197, PII: 10.1007/s00248-015-0663-y, DOI: 10.1007/s00248-015-0663-y, ISSN: 1432-184X.

Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am. J. Respir. Crit. Care Med. 2016 Jan 1/1/2016; 193(1): 31-42. PMID: 26378386, PMCID: PMC4731613, DOI: 10.1164/rccm.201410-1793OC, ISSN: 1535-4970.

Schobel SA, Stucker KM, Moore ML, Anderson LJ, Larkin EK, Shankar J, Bera J, Puri V, Shilts MH, Rosas-Salazar C, Halpin RA, Fedorova N, Shrivastava S, Stockwell TB, Peebles RS, Hartert TV, Das SR. Respiratory Syncytial Virus whole-genome sequencing identifies convergent evolution of sequence duplication in the C-terminus of the G gene. Sci Rep. 2016; 6: 26311. PMID: 27212633, PMCID: PMC4876326, PII: srep26311, DOI: 10.1038/srep26311, ISSN: 2045-2322.

Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. J. Allergy Clin. Immunol [print-electronic]. 2015 Oct; 136(4): 1025-1034.e11. PMID: 26242299, PMCID: PMC4600442, PII: S0091-6749(15)00840-4, DOI: 10.1016/j.jaci.2015.05.046, ISSN: 1097-6825.

Shelton JS, Davis LT, Peebles RS, Tillman BF, Mobley BC. Cerebral Amyloid Angiopathy Presenting with Synchronous Bilateral Intracerebral Macrohemorrhages. Case Rep Neurol. 2015 Sep; 7(3): 233-7. PMID: 26955333, PMCID: PMC4777955, PII: crn-0007-0233, DOI: 10.1159/000442085, ISSN: 1662-680X.

Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res [print-electronic]. 2015 Apr 4/15/2015; 75(8): 1624-34. PMID: 25691457, PMCID: PMC4401663, PII: 0008-5472.CAN-14-2379, DOI: 10.1158/0008-5472.CAN-14-2379, ISSN: 1538-7445.

Peebles RS. At the bedside: the emergence of group 2 innate lymphoid cells in human disease. J. Leukoc. Biol [print-electronic]. 2015 Mar; 97(3): 469-75. PMID: 25516755, PMCID: PMC4338848, PII: jlb.3BT0814-383R, DOI: 10.1189/jlb.3BT0814-383R, ISSN: 1938-3673.

Claar D, Hartert TV, Peebles RS. The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med [print-electronic]. 2015 Feb; 9(1): 55-72. PMID: 25541289, PMCID: PMC4380345, DOI: 10.1586/17476348.2015.992783, ISSN: 1747-6356.

Karlin E, Gebretsadik T, Peebles RS, Hartert TV, Langley EW, Arnold DH. Fractional exhaled nitric oxide change in pediatric patients after emergency department care of asthma exacerbations [letter]. Ann. Allergy Asthma Immunol [print-electronic]. 2015 Feb; 114(2): 149-51. PMID: 25492099, PII: S1081-1206(14)00804-7, DOI: 10.1016/j.anai.2014.11.002, ISSN: 1534-4436.

Larkin EK, Gebretsadik T, Moore ML, Anderson LJ, Dupont WD, Chappell JD, Minton PA, Peebles RS, Moore PE, Valet RS, Arnold DH, Rosas-Salazar C, Das SR, Polack FP, Hartert TV, . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med. 2015; 15: 45. PMID: 26021723, PMCID: PMC4506623, PII: 10.1186/s12890-015-0040-0, DOI: 10.1186/s12890-015-0040-0, ISSN: 1471-2466.

Hotard AL, Lee S, Currier MG, Crowe JE, Sakamoto K, Newcomb DC, Peebles RS, Plemper RK, Moore ML. Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. J. Virol [print-electronic]. 2015 Jan; 89(1): 512-22. PMID: 25339762, PMCID: PMC4301159, PII: JVI.02472-14, DOI: 10.1128/JVI.02472-14, ISSN: 1098-5514.

Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J. Allergy Clin. Immunol [print-electronic]. 2014 Dec; 134(6): 1402-1412.e7. PMID: 25216987, PMCID: PMC4261010, PII: S0091-6749(14)00968-3, DOI: 10.1016/j.jaci.2014.07.013, ISSN: 1097-6825.

Langley EW, Gebretsadik T, Hartert TV, Peebles RS, Arnold DH. Exhaled nitric oxide is associated with severity of pediatric acute asthma exacerbations. J Allergy Clin Immunol Pract [print-electronic]. 2014 Sep; 2(5): 618-20.e1. PMID: 25213059, PMCID: PMC4163006, PII: S2213-2198(14)00141-X, DOI: 10.1016/j.jaip.2014.04.004, ISSN: 2213-2201.

Miller EK, Avila PC, Khan YW, Word CR, Pelz BJ, Papadopoulos NG, Peebles RS, Heymann PW, . Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma. J Allergy Clin Immunol Pract. 2014 Sep; 2(5): 537-43. PMID: 25213046, PMCID: PMC4190166, PII: S2213-2198(14)00305-5, DOI: 10.1016/j.jaip.2014.06.024, ISSN: 2213-2201.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825.

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect. Immun [print-electronic]. 2014 Sep; 82(9): 3723-39. PMID: 24958709, PMCID: PMC4187810, PII: IAI.00035-14, DOI: 10.1128/IAI.00035-14, ISSN: 1098-5522.

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J. Virol [print-electronic]. 2014 Sep 9/1/2014; 88(17): 9655-72. PMID: 24920804, PMCID: PMC4136353, PII: JVI.03299-13, DOI: 10.1128/JVI.03299-13, ISSN: 1098-5514.

Newcomb DC, Peebles RS. Th17-mediated inflammation in asthma. Curr. Opin. Immunol [print-electronic]. 2013 Dec; 25(6): 755-60. PMID: 24035139, PMCID: PMC3855890, PII: S0952-7915(13)00130-1, DOI: 10.1016/j.coi.2013.08.002, ISSN: 1879-0372.

Toki S, Omary RA, Wilson K, Gore JC, Peebles RS, Pham W. A comprehensive analysis of transfection-assisted delivery of iron oxide nanoparticles to dendritic cells. Nanomedicine [print-electronic]. 2013 Nov; 9(8): 1235-44. PMID: 23747738, PMCID: PMC4031028, PII: S1549-9634(13)00261-X, DOI: 10.1016/j.nano.2013.05.010, ISSN: 1549-9642.

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS. Deficiency of gp91phox inhibits allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 2013 Sep; 49(3): 396-402. PMID: 23590311, PMCID: PMC3824054, DOI: 10.1165/rcmb.2012-0442OC, ISSN: 1535-4989.

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax [print-electronic]. 2013 Aug; 68(8): 717-23. PMID: 23422214, PMCID: PMC3916091, PII: thoraxjnl-2012-202404, DOI: 10.1136/thoraxjnl-2012-202404, ISSN: 1468-3296.

Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS. PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells. J. Leukoc. Biol [print-electronic]. 2013 Jul; 94(1): 77-88. PMID: 23625201, PMCID: PMC3685021, PII: jlb.1112559, DOI: 10.1189/jlb.1112559, ISSN: 1938-3673.

Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. Am. J. Respir. Cell Mol. Biol. 2013 Jun; 48(6): 711-6. PMID: 23392574, PMCID: PMC3727878, PII: rcmb.2013-0017OC, DOI: 10.1165/rcmb.2013-0017OC, ISSN: 1535-4989.

Peebles RS. A new horizon in asthma: inhibiting ILC function. Sci Transl Med. 2013 Feb 2/27/2013; 5(174): 174fs7. PMID: 23447016, PII: 5/174/174fs7, DOI: 10.1126/scitranslmed.3005881, ISSN: 1946-6242.

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606.

Lotz MT, Moore ML, Peebles RS. Respiratory syncytial virus and reactive airway disease. Curr. Top. Microbiol. Immunol. 2013; 372: 105-18. PMID: 24362686, PMCID: PMC4322419, DOI: 10.1007/978-3-642-38919-1_5, ISSN: 0070-217X.

Lotz MT, Peebles RS. Mechanisms of respiratory syncytial virus modulation of airway immune responses. Curr Allergy Asthma Rep. 2012 Oct; 12(5): 380-7. PMID: 22692775, PMCID: PMC3432290, DOI: 10.1007/s11882-012-0278-z, ISSN: 1534-6315.

James KM, Peebles RS, Hartert TV. Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility?. J. Allergy Clin. Immunol. 2012 Aug; 130(2): 343-51. PMID: 22846746, PMCID: PMC3410318, PII: S0091-6749(12)01031-7, DOI: 10.1016/j.jaci.2012.05.056, ISSN: 1097-6825.

Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS. Epithelial nuclear factor-¿B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene [print-electronic]. 2012 Jun 6/28/2012; 31(26): 3164-76. PMID: 22002309, PMCID: PMC3266969, PII: onc2011480, DOI: 10.1038/onc.2011.480, ISSN: 1476-5594.

Newcomb DC, Boswell MG, Huckabee MM, Goleniewska K, Dulek DE, Reiss S, Lukacs NW, Kolls JK, Peebles RS. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J. Immunol [print-electronic]. 2012 Feb 2/1/2012; 188(3): 1027-35. PMID: 22210911, PMCID: PMC3262924, PII: jimmunol.1102216, DOI: 10.4049/jimmunol.1102216, ISSN: 1550-6606.

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS ONE [print-electronic]. 2012; 7(5): e33518. PMID: 22590492, PMCID: PMC3349674, PII: PONE-D-10-03779, DOI: 10.1371/journal.pone.0033518, ISSN: 1932-6203.

Dorris SL, Peebles RS. PGI2 as a regulator of inflammatory diseases. Mediators Inflamm [print-electronic]. 2012; 2012: 926968. PMID: 22851816, PMCID: PMC3407649, DOI: 10.1155/2012/926968, ISSN: 1466-1861.

Boswell MG, Zhou W, Newcomb DC, Peebles RS. PGI2 as a regulator of CD4+ subset differentiation and function. Prostaglandins Other Lipid Mediat [print-electronic]. 2011 Nov; 96(1-4): 21-6. PMID: 21864703, PMCID: PMC3215832, PII: S1098-8823(11)00073-6, DOI: 10.1016/j.prostaglandins.2011.08.003, ISSN: 1098-8823.

Dulek DE, Peebles RS. Viruses and asthma. Biochim. Biophys. Acta [print-electronic]. 2011 Nov; 1810(11): 1080-90. PMID: 21291960, PMCID: PMC3130828, PII: S0304-4165(11)00031-6, DOI: 10.1016/j.bbagen.2011.01.012, ISSN: 0006-3002.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504.

Dulek DE, Peebles RS. Bacteria and asthma: more there than we thought. Expert Rev Respir Med. 2011 Jun; 5(3): 329-32. PMID: 21702654, PMCID: PMC3929126, DOI: 10.1586/ers.11.33, ISSN: 1747-6356.

Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J. Allergy Clin. Immunol [print-electronic]. 2011 Apr; 127(4): 1006-13.e1. PMID: 21236478, PMCID: PMC3916096, PII: S0091-6749(10)01865-8, DOI: 10.1016/j.jaci.2010.11.043, ISSN: 1097-6825.

Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS, Blackwell TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1273-81. PMID: 20595227, PMCID: PMC3001265, PII: 201001-0001OC, DOI: 10.1164/rccm.201001-0001OC, ISSN: 1535-4970.

Westerly BD, Peebles RS. Respiratory syncytial virus infections in the adult asthmatic--mechanisms of host susceptibility and viral subversion. Immunol Allergy Clin North Am [print-electronic]. 2010 Nov; 30(4): 523-39, vi. PMID: 21029936, PMCID: PMC2966842, PII: S0889-8561(10)00070-6, DOI: 10.1016/j.iac.2010.08.006, ISSN: 1557-8607.

Sevin CM, Peebles RS. Infections and asthma: new insights into old ideas. Clin. Exp. Allergy. 2010 Aug; 40(8): 1142-54. PMID: 20649609, PII: CEA3563, DOI: 10.1111/j.1365-2222.2010.03563.x, ISSN: 1365-2222.

Hartert TV, Carroll K, Gebretsadik T, Woodward K, Minton P, . The Tennessee Children's Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases. Respirology [print-electronic]. 2010 May; 15(4): 691-9. PMID: 20409023, PMCID: PMC2992986, PII: RES1743, DOI: 10.1111/j.1440-1843.2010.01743.x, ISSN: 1440-1843.

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2010 May; 42(5): 564-71. PMID: 19556606, PMCID: PMC2874442, PII: 2008-0391OC, DOI: 10.1165/rcmb.2008-0391OC, ISSN: 1535-4989.

Sheller JR, Polosukhin VV, Mitchell D, Cheng DS, Peebles RS, Blackwell TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp. Lung Res. 2009 Dec; 35(10): 883-95. PMID: 19995280, PMCID: PMC3419942, DOI: 10.3109/01902140903019710, ISSN: 1521-0499.

Yin H, Liu W, Goleniewska K, Porter NA, Morrow JD, Peebles RS. Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation. Free Radic. Biol. Med [print-electronic]. 2009 Sep 9/1/2009; 47(5): 622-8. PMID: 19501157, PMCID: PMC2716436, PII: S0891-5849(09)00332-3, DOI: 10.1016/j.freeradbiomed.2009.05.033, ISSN: 1873-4596.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J. Immunol [print-electronic]. 2009 Aug 8/1/2009; 183(3): 2016-26. PMID: 19587017, PMCID: PMC3755459, PII: jimmunol.0803167, DOI: 10.4049/jimmunol.0803167, ISSN: 1550-6606.

Newcomb DC, Peebles RS. Bugs and asthma: a different disease?. Proc Am Thorac Soc. 2009 May 5/1/2009; 6(3): 266-71. PMID: 19387028, PMCID: PMC2677401, PII: 6/3/266, DOI: 10.1513/pats.200806-056RM, ISSN: 1546-3222.

Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J. Immunol. 2009 May 5/1/2009; 182(9): 5317-21. PMID: 19380778, PMCID: PMC3711250, PII: 182/9/5317, DOI: 10.4049/jimmunol.0803868, ISSN: 1550-6606.

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE, Goleniewska K, Williams JV, Collins PL, Peebles RS. A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J. Virol [print-electronic]. 2009 May; 83(9): 4185-94. PMID: 19211758, PMCID: PMC2668460, PII: JVI.01853-08, DOI: 10.1128/JVI.01853-08, ISSN: 1098-5514.

Huckabee MM, Peebles RS. Novel concepts in virally induced asthma. Clin Mol Allergy. 2009; 7: 2. PMID: 19154602, PMCID: PMC2651109, PII: 1476-7961-7-2, DOI: 10.1186/1476-7961-7-2, ISSN: 1476-7961.

Hashimoto K, Ishibashi K, Gebretsadik T, Hartert TV, Yamamoto A, Nakayama T, Ohashi K, Sakata H, Kawasaki Y, Katayose M, Sakuma H, Suzuki H, Hosoya M, Peebles RS, Suzutani T. Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children. J. Med. Virol. 2008 Nov; 80(11): 2015-22. PMID: 18814254, DOI: 10.1002/jmv.21318, ISSN: 1096-9071.

Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol. 2008 Oct 10/15/2008; 181(8): 5360-7. PMID: 18832692, PII: 181/8/5360, ISSN: 1550-6606.

Moore ML, Chi MH, Goleniewska K, Durbin JE, Peebles RS. Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. Viral Immunol. 2008 Sep; 21(3): 327-39. PMID: 18788941, PMCID: PMC2952133, DOI: 10.1089/vim.2008.0003, ISSN: 1557-8976.

Temiño VM, Peebles RS. The spectrum and treatment of angioedema. Am. J. Med. 2008 Apr; 121(4): 282-6. PMID: 18374684, PII: S0002-9343(07)01091-1, DOI: 10.1016/j.amjmed.2007.09.024, ISSN: 1555-7162.

Rudd BD, Luker GD, Luker KE, Peebles RS, Lukacs NW. Type I interferon regulates respiratory virus infected dendritic cell maturation and cytokine production. Viral Immunol. 2007 Dec; 20(4): 531-40. PMID: 18158727, DOI: 10.1089/vim.2007.0057, ISSN: 0882-8245.

Peebles RS, Moore ML. A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy [editorial]. Am. J. Respir. Cell Mol. Biol. 2007 Oct; 37(4): 375-7. PMID: 17872592, PII: 37/4/375, DOI: 10.1165/rcmb.2007-0003ED, ISSN: 1044-1549.

Joo M, Kwon M, Sadikot RT, Kingsley PJ, Marnett LJ, Blackwell TS, Peebles RS, Urade Y, Christman JW. Induction and function of lipocalin prostaglandin D synthase in host immunity. J. Immunol. 2007 Aug 8/15/2007; 179(4): 2565-75. PMID: 17675519, PII: 179/4/2565, ISSN: 0022-1767.

Sadikot RT, Zeng H, Azim AC, Joo M, Dey SK, Breyer RM, Peebles RS, Blackwell TS, Christman JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur. J. Immunol. 2007 Apr; 37(4): 1001-9. PMID: 17330822, DOI: 10.1002/eji.200636636, ISSN: 0014-2980.

Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J. Leukoc. Biol [print-electronic]. 2007 Mar; 81(3): 809-17. PMID: 17135575, PII: jlb.0606375, DOI: 10.1189/jlb.0606375, ISSN: 0741-5400.

Moore ML, Chi MH, Zhou W, Goleniewska K, O'Neal JF, Higginbotham JN, Peebles RS. Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity. J. Immunol. 2007 Mar 3/1/2007; 178(5): 2651-4. PMID: 17312105, PII: 178/5/2651, ISSN: 0022-1767.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J. Immunol. 2007 Jan 1/15/2007; 178(2): 702-10. PMID: 17202330, PII: 178/2/702, ISSN: 0022-1767.

Moore ML, Peebles RS. Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics. Pharmacol. Ther [print-electronic]. 2006 Nov; 112(2): 405-24. PMID: 16820210, PII: S0163-7258(06)00067-2, DOI: 10.1016/j.pharmthera.2006.04.008, ISSN: 0163-7258.

Moore PE, Cunningham G, Calder MM, DeMatteo AD, Peeples ME, Summar ML, Peebles RS. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Nov; 35(5): 559-64. PMID: 16763224, PMCID: PMC2643275, PII: 2005-0282OC, DOI: 10.1165/rcmb.2005-0282OC, ISSN: 1044-1549.

Zhou W, Hashimoto K, Moore ML, Elias JA, Zhu Z, Durbin J, Colasurdo G, Rutigliano JA, Chiappetta CL, Goleniewska K, O'Neal JF, Graham BS, Peebles RS. IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect [print-electronic]. 2006 Nov; 8(14-15): 2880-9. PMID: 17110149, PMCID: PMC1811125, PII: S1286-4579(06)00351-0, DOI: 10.1016/j.micinf.2006.09.007, ISSN: 1286-4579.

Lukacs NW, Moore ML, Rudd BD, Berlin AA, Collins RD, Olson SJ, Ho SB, Peebles RS. Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus. Am. J. Pathol. 2006 Sep; 169(3): 977-86. PMID: 16936271, PMCID: PMC1698832, PII: S0002-9440(10)62773-3, DOI: 10.2353/ajpath.2006.051055, ISSN: 0002-9440.

Venarske DL, Busse WW, Griffin MR, Gebretsadik T, Shintani AK, Minton PA, Peebles RS, Hamilton R, Weisshaar E, Vrtis R, Higgins SB, Hartert TV. The relationship of rhinovirus-associated asthma hospitalizations with inhaled corticosteroids and smoking. J. Infect. Dis [print-electronic]. 2006 Jun 6/1/2006; 193(11): 1536-43. PMID: 16652282, PII: JID35913, DOI: 10.1086/503809, ISSN: 0022-1899.

Moore ML, Peebles RS. Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think. J. Allergy Clin. Immunol [print-electronic]. 2006 May; 117(5): 1036-9. PMID: 16675329, PII: S0091-6749(05)04039-X, DOI: 10.1016/j.jaci.2005.12.1314, ISSN: 0091-6749.

Talati M, Meyrick B, Peebles RS, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ, Sheller JR. Oxidant stress modulates murine allergic airway responses. Free Radic. Biol. Med [print-electronic]. 2006 Apr 4/1/2006; 40(7): 1210-9. PMID: 16545689, PII: S0891-5849(05)00710-0, DOI: 10.1016/j.freeradbiomed.2005.11.012, ISSN: 0891-5849.

Peebles RS, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J. Immunol. 2005 Dec 12/15/2005; 175(12): 8253-9. PMID: 16339565, PII: 175/12/8253, ISSN: 0022-1767.

Kalomenidis I, Guo Y, Peebles RS, Lane KB, Papiris S, Elias J, Light RW. Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent. Chest. 2005 Oct; 128(4): 2978-83. PMID: 16236975, PII: 128/4/2978, DOI: 10.1378/chest.128.4.2978, ISSN: 0012-3692.

Williams JV, Crowe JE, Enriquez R, Minton P, Peebles RS, Hamilton RG, Higgins S, Griffin M, Hartert TV. Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults. J. Infect. Dis [print-electronic]. 2005 Oct 10/1/2005; 192(7): 1149-53. PMID: 16136455, PMCID: PMC1476781, PII: JID34247, DOI: 10.1086/444392, ISSN: 0022-1899.

Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK, Dubin PJ, Sheller JR, Goleniewska K, O'Neal JF, Olson SJ, Mitchell D, Graham BS, Peebles RS. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J. Allergy Clin. Immunol. 2005 Sep; 116(3): 550-7. PMID: 16159623, PII: S0091-6749(05)01278-9, DOI: 10.1016/j.jaci.2005.03.051, ISSN: 0091-6749.

Hashimoto K, Sheller JR, Morrow JD, Collins RD, Goleniewska K, O'Neal J, Zhou W, Ji S, Mitchell DB, Graham BS, Peebles RS. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J. Immunol. 2005 Jan 1/1/2005; 174(1): 525-32. PMID: 15611279, PII: 174/1/525, ISSN: 0022-1767.

Johnson RF, Peebles RS. Anaphylactic shock: pathophysiology, recognition, and treatment. Semin Respir Crit Care Med. 2004 Dec; 25(6): 695-703. PMID: 16088511, DOI: 10.1055/s-2004-860983, ISSN: 1069-3424.

Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K, Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright PF, Collins RD, Suzutani T, Peebles RS. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. J. Virol. 2004 Oct; 78(19): 10303-9. PMID: 15367596, PMCID: PMC516432, PII: 78/19/10303, DOI: 10.1128/JVI.78.19.10303-10309.2004, ISSN: 0022-538X.

Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF, Peebles RS. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am. J. Respir. Crit. Care Med [print-electronic]. 2004 Aug 8/1/2004; 170(3): 306-12. PMID: 15130904, PII: 200301-030OC, DOI: 10.1164/rccm.200301-030OC, ISSN: 1073-449X.

Peebles RS. Viral infections, atopy, and asthma: is there a causal relationship?. J. Allergy Clin. Immunol. 2004 Jan; 113(1 Suppl): S15-8. PMID: 14694345, PII: S0091674903024758, DOI: 10.1016/j.jaci.2003.10.033, ISSN: 0091-6749.

Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, Jansen ED, Yull FE, Christman JW, Blackwell TS. Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. J. Immunol. 2003 Jan 1/15/2003; 170(2): 1091-8. PMID: 12517978, ISSN: 0022-1767.

Peebles RS, Hashimoto K, Graham BS. The complex relationship between respiratory syncytial virus and allergy in lung disease. Viral Immunol. 2003; 16(1): 25-34. PMID: 12725686, DOI: 10.1089/088282403763635429, ISSN: 0882-8245.

Peebles RS, Hartert TV. Highlights from the annual scientific assembly: patient-centered approaches to asthma management: strategies for treatment and management of asthma. South. Med. J. 2002 Jul; 95(7): 775-9. PMID: 12144090, ISSN: 0038-4348.

Hashimoto K, Peebles RS, Sheller JR, Jarzecka K, Furlong J, Mitchell DB, Hartert TV, Graham BS. Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor. Thorax. 2002 Jun; 57(6): 524-7. PMID: 12037228, PMCID: PMC1746359, ISSN: 0040-6376.

Rusznak C, Peebles RS. Anaphylaxis and anaphylactoid reactions. A guide to prevention, recognition, and emergent treatment. Postgrad Med. 2002 May; 111(5): 101-4, 107. PMID: 12040857, ISSN: 0032-5481.

Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD, Hashimoto Y, Christman JW, Kang KH, Jarzecka K, Furlong J, Mitchell DB, Talati M, Graham BS, Sheller JR. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 2002 Apr 4/15/2002; 165(8): 1154-60. PMID: 11956061, DOI: 10.1164/ajrccm.165.8.2106025, ISSN: 1073-449X.

Peebles RS, Hashimoto K, Collins RD, Jarzecka K, Furlong J, Mitchell DB, Sheller JR, Graham BS. Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges. J. Infect. Dis [print-electronic]. 2001 Dec 12/1/2001; 184(11): 1374-9. PMID: 11709778, PII: JID010747, DOI: 10.1086/324429, ISSN: 0022-1899.

Hartert TV, Peebles RS. Dietary antioxidants and adult asthma. Curr Opin Allergy Clin Immunol. 2001 Oct; 1(5): 421-9. PMID: 11964722, ISSN: 1528-4050.

Peebles RS, Sheller JR, Collins RD, Jarzecka AK, Mitchell DB, Parker RA, Graham BS. Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in mice. J. Med. Virol. 2001 Feb; 63(2): 178-88. PMID: 11170055, PII: 10.1002/1096-9071(20000201)63:2<178::AID-JMV1013>3.0.CO;2-O, ISSN: 0146-6615.

Peebles RS, Graham BS. Viruses, dendritic cells and the lung. Respir. Res [print-electronic]. 2001; 2(4): 245-9. PMID: 11686890, PMCID: PMC59582, ISSN: 1465-9921.

Graham BS, Johnson TR, Peebles RS, Fischer JE. Reply. J. Infect. Dis. 2000 Oct; 182(4): 1288-9. PMID: 10979939, PII: JID000665, DOI: 10.1086/315846, ISSN: 1537-6613.

Peebles RS, Sheller JR, Collins RD, Jarzecka K, Mitchell DB, Graham BS. Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV. J. Infect. Dis [print-electronic]. 2000 Sep; 182(3): 671-7. PMID: 10950758, PII: JID000415, DOI: 10.1086/315783, ISSN: 0022-1899.

Peebles RS, Dworski R, Collins RD, Jarzecka K, Mitchell DB, Graham BS, Sheller JR. Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am. J. Respir. Crit. Care Med. 2000 Aug; 162(2 Pt 1): 676-81. PMID: 10934105, DOI: 10.1164/ajrccm.162.2.9911063, ISSN: 1073-449X.

Graham BS, Johnson TR, Peebles RS. Immune-mediated disease pathogenesis in respiratory syncytial virus infection. Immunopharmacology. 2000 Jul 7/25/2000; 48(3): 237-47. PMID: 10960663, PII: S0162310900002332, ISSN: 0162-3109.

Peebles RS, Carpenter CT, Dupont WD, Loyd JE. Mediastinal fibrosis is associated with human leukocyte antigen-A2. Chest. 2000 Feb; 117(2): 482-5. PMID: 10669694, PII: S0012-3692(15)48641-6, ISSN: 0012-3692.

Peebles RS, Hartert TV. Respiratory viruses and asthma. Curr Opin Pulm Med. 2000 Jan; 6(1): 10-4. PMID: 10608419, ISSN: 1070-5287.

Hartert TV, Peebles RS. Epidemiology of asthma: the year in review. Curr Opin Pulm Med. 2000 Jan; 6(1): 4-9. PMID: 10608418, ISSN: 1070-5287.

Fischer JE, Johnson TR, Peebles RS, Graham BS. Vaccination with pertussis toxin alters the antibody response to simultaneous respiratory syncytial virus challenge. J. Infect. Dis. 1999 Sep; 180(3): 714-9. PMID: 10438359, PII: JID981582, DOI: 10.1086/314947, ISSN: 0022-1899.

Peebles RS, Sheller JR, Johnson JE, Mitchell DB, Graham BS. Respiratory syncytial virus infection prolongs methacholine-induced airway hyperresponsiveness in ovalbumin-sensitized mice. J. Med. Virol. 1999 Feb; 57(2): 186-92. PMID: 9892406, PII: 10.1002/(SICI)1096-9071(199902)57:2<186::AID-JMV17>3.0.CO;2-Q, ISSN: 0146-6615.

Peebles RS, Hartert TV, Sheller JR. Viral infections in asthma. Compr Ther. 1998 Oct; 24(10): 511-8. PMID: 9801850, ISSN: 0098-8243.

Peebles RS, Hartert TV. In vivo diagnostic procedures: skin testing, nasal provocation, and bronchial provocation. Methods. 1997 Sep; 13(1): 14-24. PMID: 9281464, PII: S1046-2023(97)90492-8, DOI: 10.1006/meth.1997.0492, ISSN: 1046-2023.

Available Postdoctoral Position Details
Posted: 3/5/2013
Post-doctoral research fellow position will be open in Sepetmber 2009. Funding will be provided by the Peebles lab; however, the expectation is that the candidate will be eligible for an NIH F32 or T32 grant. Our lab has a strong track record in obtaining these grants for post-doctoral fellows.