Faculty Appointments
Professor of Anesthesiology
Education
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., Medicine, University of South Dakota, Vermillion, South DakotaB.S., Biological Sciences, University of Nebraska, Lincoln, Nebraska
Publications
Gangopadhyay M, Smith H, Pao M, Silver G, Deepmala D, De Souza C, Garcia G, Giles L, Denton D, Jacobowski N, Pandharipande P, Fuchs C. Development of the Vanderbilt Assessment for Delirium in Infants and Children to Standardize Pediatric Delirium Assessment By Psychiatrists. Psychosomatics [print-electronic]. 2017 Jul; 58(4): 355-63. PMID: 28506544, PMCID: PMC5482775, PII: S0033-3182(17)30071-3, DOI: 10.1016/j.psym.2017.03.006, ISSN: 1545-7206.
Pandharipande PP, Ely EW, Arora RC, Balas MC, Boustani MA, La Calle GH, Cunningham C, Devlin JW, Elefante J, Han JH, MacLullich AM, Maldonado JR, Morandi A, Needham DM, Page VJ, Rose L, Salluh JIF, Sharshar T, Shehabi Y, Skrobik Y, Slooter AJC, Smith HAB. The intensive care delirium research agenda: a multinational, interprofessional perspective. Intensive Care Med [print-electronic]. 2017 Jun 6/13/2017; PMID: 28612089, PII: 10.1007/s00134-017-4860-7, DOI: 10.1007/s00134-017-4860-7, ISSN: 1432-1238.
Smith HAB, Gangopadhyay M, Goben CM, Jacobowski NL, Chestnut MH, Thompson JL, Chandrasekhar R, Williams SR, Griffith K, Ely EW, Fuchs DC, Pandharipande PP. Delirium and Benzodiazepines Associated With Prolonged ICU Stay in Critically Ill Infants and Young Children. Crit. Care Med [print-electronic]. 2017 Jun 6/7/2017; PMID: 28594681, DOI: 10.1097/CCM.0000000000002515, ISSN: 1530-0293.
Smith HA, Han JH, Ely EW. Meeting the Challenges of Delirium Assessment Across the Aging Spectrum. Crit. Care Med. 2016 Sep; 44(9): 1775-7. PMID: 27525996, PMCID: PMC4988335, PII: 00003246-201609000-00018, DOI: 10.1097/CCM.0000000000001966, ISSN: 1530-0293.
Smith HA, Gangopadhyay M, Goben CM, Jacobowski NL, Chestnut MH, Savage S, Rutherford MT, Denton D, Thompson JL, Chandrasekhar R, Acton M, Newman J, Noori HP, Terrell MK, Williams SR, Griffith K, Cooper TJ, Ely EW, Fuchs DC, Pandharipande PP. The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children. Crit. Care Med. 2016 Mar; 44(3): 592-600. PMID: 26565631, PMCID: PMC4764386, DOI: 10.1097/CCM.0000000000001428, ISSN: 1530-0293.
McGrane S, Smith HAB, Pandharipande PP. Acute Brain Dysfunction During Critical Illness. ICU. 2015; 15(4).
Smith HAB, Goben C, Pandharipande PP. Current Concepts in Pediatric Critical Care. Rigby MR, Graciano AL, editors. Mount Prospect (United States): Society of Critical Care Medicine; 2014.11 p.
Smith HA, Brink E, Fuchs DC, Ely EW, Pandharipande PP. Pediatric delirium: monitoring and management in the pediatric intensive care unit. Pediatr. Clin. North Am [print-electronic]. 2013 Jun; 60(3): 741-60. PMID: 23639666, PII: S0031-3955(13)00024-2, DOI: 10.1016/j.pcl.2013.02.010, ISSN: 1557-8240.
Smith HA, Berutti T, Brink E, Strohler B, Fuchs DC, Ely EW, Pandharipande PP. Pediatric critical care perceptions on analgesia, sedation, and delirium. Semin Respir Crit Care Med [print-electronic]. 2013 Apr; 34(2): 244-61. PMID: 23716315, DOI: 10.1055/s-0033-1342987, ISSN: 1098-9048.
Franco JG, Ricardo C, Muñoz JF, de Pablo J, W P, Ely EW, Smith HA. Diagnosing delirium in critically ill children: Spanish translation and cultural adaptation of the Pediatric Confusion Assessment Method for the Intensive Care Unit [letter]. Crit. Care Med. 2012 Mar; 40(3): 1034. PMID: 22343876, PMCID: PMC3826446, PII: 00003246-201203000-00075, DOI: 10.1097/CCM.0b013e31823c8b1c, ISSN: 1530-0293.
de Grahl C, Luetz A, Gratopp A, Gensel D, Mueller J, Smith H, Ely EW, Krude H, Spies C. The paediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU): translation and cognitive debriefing for the German-speaking area. Ger Med Sci [print-electronic]. 2012; 10: Doc07. PMID: 22557940, PMCID: PMC3334933, PII: 000158, DOI: 10.3205/000158, ISSN: 1612-3174.
Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Anesthesiol Clin. 2011 Dec; 29(4): 729-50. PMID: 22078920, PII: S1932-2275(11)00086-3, DOI: 10.1016/j.anclin.2011.09.011, ISSN: 1932-2275.
Smith HA, Boyd J, Fuchs DC, Melvin K, Berry P, Shintani A, Eden SK, Terrell MK, Boswell T, Wolfram K, Sopfe J, Barr FE, Pandharipande PP, Ely EW. Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit. Care Med. 2011 Jan; 39(1): 150-7. PMID: 20959783, PMCID: PMC3776416, DOI: 10.1097/CCM.0b013e3181feb489, ISSN: 1530-0293.
Ananthakrishnan M, Barr FE, Summar ML, Smith HA, Kaplowitz M, Cunningham G, Magarik J, Zhang Y, Fike CD. L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Sep; 297(3): L506-11. PMID: 19617312, PII: 00017.2009, DOI: 10.1152/ajplung.00017.2009, ISSN: 1522-1504.
Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin. 2009 Jul; 25(3): 593-614, x. PMID: 19576533, PMCID: PMC2793079, PII: S0749-0704(09)00041-4, DOI: 10.1016/j.ccc.2009.05.002, ISSN: 1557-8232.
Barr FE, Tirona RG, Taylor MB, Rice G, Arnold J, Cunningham G, Smith HA, Campbell A, Canter JA, Christian KG, Drinkwater DC, Scholl F, Kavanaugh-McHugh A, Summar ML. Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: potential therapy for postoperative pulmonary hypertension. J. Thorac. Cardiovasc. Surg. 2007 Aug; 134(2): 319-26. PMID: 17662768, PII: S0022-5223(07)00616-2, DOI: 10.1016/j.jtcvs.2007.02.043, ISSN: 1097-685X.
Canter JA, Summar ML, Smith HB, Rice GD, Hall LD, Ritchie MD, Motsinger AA, Christian KG, Drinkwater DC, Scholl FG, Dyer KL, Kavanaugh-McHugh AL, Barr FE. Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion [print-electronic]. 2007 May; 7(3): 204-10. PMID: 17188582, PMCID: PMC1929167, PII: S1567-7249(06)00218-2, DOI: 10.1016/j.mito.2006.11.001, ISSN: 1567-7249.
Smith HA, Canter JA, Christian KG, Drinkwater DC, Scholl FG, Christman BW, Rice GD, Barr FE, Summar ML. Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. J. Thorac. Cardiovasc. Surg. 2006 Jul; 132(1): 58-65. PMID: 16798303, PII: S0022-5223(06)00316-3, DOI: 10.1016/j.jtcvs.2006.02.012, ISSN: 1097-685X.
Summar ML, Hall L, Christman B, Barr F, Smith H, Kallianpur A, Brown N, Yadav M, Willis A, Eeds A, Cermak E, Summar S, Wilson A, Arvin M, Putnam A, Wills M, Cunningham G. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol. Genet. Metab. 2004 Apr; 81 Suppl 1: S12-9. PMID: 15050969, PII: S1096719204000083, DOI: 10.1016/j.ymgme.2003.11.014, ISSN: 1096-7192.
Barr FE, Beverley H, VanHook K, Cermak E, Christian K, Drinkwater D, Dyer K, Raggio NT, Moore JH, Christman B, Summar M. Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J. Pediatr. 2003 Jan; 142(1): 26-30. PMID: 12520250, PII: S0022-3476(02)40213-2, DOI: 10.1067/mpd.2003.mpd0311, ISSN: 0022-3476.
Pandharipande PP, Ely EW, Arora RC, Balas MC, Boustani MA, La Calle GH, Cunningham C, Devlin JW, Elefante J, Han JH, MacLullich AM, Maldonado JR, Morandi A, Needham DM, Page VJ, Rose L, Salluh JIF, Sharshar T, Shehabi Y, Skrobik Y, Slooter AJC, Smith HAB. The intensive care delirium research agenda: a multinational, interprofessional perspective. Intensive Care Med [print-electronic]. 2017 Jun 6/13/2017; PMID: 28612089, PII: 10.1007/s00134-017-4860-7, DOI: 10.1007/s00134-017-4860-7, ISSN: 1432-1238.
Smith HAB, Gangopadhyay M, Goben CM, Jacobowski NL, Chestnut MH, Thompson JL, Chandrasekhar R, Williams SR, Griffith K, Ely EW, Fuchs DC, Pandharipande PP. Delirium and Benzodiazepines Associated With Prolonged ICU Stay in Critically Ill Infants and Young Children. Crit. Care Med [print-electronic]. 2017 Jun 6/7/2017; PMID: 28594681, DOI: 10.1097/CCM.0000000000002515, ISSN: 1530-0293.
Smith HA, Han JH, Ely EW. Meeting the Challenges of Delirium Assessment Across the Aging Spectrum. Crit. Care Med. 2016 Sep; 44(9): 1775-7. PMID: 27525996, PMCID: PMC4988335, PII: 00003246-201609000-00018, DOI: 10.1097/CCM.0000000000001966, ISSN: 1530-0293.
Smith HA, Gangopadhyay M, Goben CM, Jacobowski NL, Chestnut MH, Savage S, Rutherford MT, Denton D, Thompson JL, Chandrasekhar R, Acton M, Newman J, Noori HP, Terrell MK, Williams SR, Griffith K, Cooper TJ, Ely EW, Fuchs DC, Pandharipande PP. The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children. Crit. Care Med. 2016 Mar; 44(3): 592-600. PMID: 26565631, PMCID: PMC4764386, DOI: 10.1097/CCM.0000000000001428, ISSN: 1530-0293.
McGrane S, Smith HAB, Pandharipande PP. Acute Brain Dysfunction During Critical Illness. ICU. 2015; 15(4).
Smith HAB, Goben C, Pandharipande PP. Current Concepts in Pediatric Critical Care. Rigby MR, Graciano AL, editors. Mount Prospect (United States): Society of Critical Care Medicine; 2014.11 p.
Smith HA, Brink E, Fuchs DC, Ely EW, Pandharipande PP. Pediatric delirium: monitoring and management in the pediatric intensive care unit. Pediatr. Clin. North Am [print-electronic]. 2013 Jun; 60(3): 741-60. PMID: 23639666, PII: S0031-3955(13)00024-2, DOI: 10.1016/j.pcl.2013.02.010, ISSN: 1557-8240.
Smith HA, Berutti T, Brink E, Strohler B, Fuchs DC, Ely EW, Pandharipande PP. Pediatric critical care perceptions on analgesia, sedation, and delirium. Semin Respir Crit Care Med [print-electronic]. 2013 Apr; 34(2): 244-61. PMID: 23716315, DOI: 10.1055/s-0033-1342987, ISSN: 1098-9048.
Franco JG, Ricardo C, Muñoz JF, de Pablo J, W P, Ely EW, Smith HA. Diagnosing delirium in critically ill children: Spanish translation and cultural adaptation of the Pediatric Confusion Assessment Method for the Intensive Care Unit [letter]. Crit. Care Med. 2012 Mar; 40(3): 1034. PMID: 22343876, PMCID: PMC3826446, PII: 00003246-201203000-00075, DOI: 10.1097/CCM.0b013e31823c8b1c, ISSN: 1530-0293.
de Grahl C, Luetz A, Gratopp A, Gensel D, Mueller J, Smith H, Ely EW, Krude H, Spies C. The paediatric Confusion Assessment Method for the Intensive Care Unit (pCAM-ICU): translation and cognitive debriefing for the German-speaking area. Ger Med Sci [print-electronic]. 2012; 10: Doc07. PMID: 22557940, PMCID: PMC3334933, PII: 000158, DOI: 10.3205/000158, ISSN: 1612-3174.
Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Anesthesiol Clin. 2011 Dec; 29(4): 729-50. PMID: 22078920, PII: S1932-2275(11)00086-3, DOI: 10.1016/j.anclin.2011.09.011, ISSN: 1932-2275.
Smith HA, Boyd J, Fuchs DC, Melvin K, Berry P, Shintani A, Eden SK, Terrell MK, Boswell T, Wolfram K, Sopfe J, Barr FE, Pandharipande PP, Ely EW. Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit. Care Med. 2011 Jan; 39(1): 150-7. PMID: 20959783, PMCID: PMC3776416, DOI: 10.1097/CCM.0b013e3181feb489, ISSN: 1530-0293.
Ananthakrishnan M, Barr FE, Summar ML, Smith HA, Kaplowitz M, Cunningham G, Magarik J, Zhang Y, Fike CD. L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Sep; 297(3): L506-11. PMID: 19617312, PII: 00017.2009, DOI: 10.1152/ajplung.00017.2009, ISSN: 1522-1504.
Smith HA, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin. 2009 Jul; 25(3): 593-614, x. PMID: 19576533, PMCID: PMC2793079, PII: S0749-0704(09)00041-4, DOI: 10.1016/j.ccc.2009.05.002, ISSN: 1557-8232.
Barr FE, Tirona RG, Taylor MB, Rice G, Arnold J, Cunningham G, Smith HA, Campbell A, Canter JA, Christian KG, Drinkwater DC, Scholl F, Kavanaugh-McHugh A, Summar ML. Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: potential therapy for postoperative pulmonary hypertension. J. Thorac. Cardiovasc. Surg. 2007 Aug; 134(2): 319-26. PMID: 17662768, PII: S0022-5223(07)00616-2, DOI: 10.1016/j.jtcvs.2007.02.043, ISSN: 1097-685X.
Canter JA, Summar ML, Smith HB, Rice GD, Hall LD, Ritchie MD, Motsinger AA, Christian KG, Drinkwater DC, Scholl FG, Dyer KL, Kavanaugh-McHugh AL, Barr FE. Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion [print-electronic]. 2007 May; 7(3): 204-10. PMID: 17188582, PMCID: PMC1929167, PII: S1567-7249(06)00218-2, DOI: 10.1016/j.mito.2006.11.001, ISSN: 1567-7249.
Smith HA, Canter JA, Christian KG, Drinkwater DC, Scholl FG, Christman BW, Rice GD, Barr FE, Summar ML. Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. J. Thorac. Cardiovasc. Surg. 2006 Jul; 132(1): 58-65. PMID: 16798303, PII: S0022-5223(06)00316-3, DOI: 10.1016/j.jtcvs.2006.02.012, ISSN: 1097-685X.
Summar ML, Hall L, Christman B, Barr F, Smith H, Kallianpur A, Brown N, Yadav M, Willis A, Eeds A, Cermak E, Summar S, Wilson A, Arvin M, Putnam A, Wills M, Cunningham G. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol. Genet. Metab. 2004 Apr; 81 Suppl 1: S12-9. PMID: 15050969, PII: S1096719204000083, DOI: 10.1016/j.ymgme.2003.11.014, ISSN: 1096-7192.
Barr FE, Beverley H, VanHook K, Cermak E, Christian K, Drinkwater D, Dyer K, Raggio NT, Moore JH, Christman B, Summar M. Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J. Pediatr. 2003 Jan; 142(1): 26-30. PMID: 12520250, PII: S0022-3476(02)40213-2, DOI: 10.1067/mpd.2003.mpd0311, ISSN: 0022-3476.