Faculty Appointments
Professor of Obstetrics and Gynecology
Education
M.D., Medicine, University of Alabama, Birmingham, AlabamaB.S., Biology, Emory University, Atlanta, Georgia
Office Address
1161 21st Ave South
B-1100 MCN
Nashville, TN 37232
B-1100 MCN
Nashville, TN 37232
Research Description
Collaborating with Dr. Kevin Osteen on an in vivo mouse model of adhesion formation. Focus is on adhesions formed in response to surgical injury and endometriosis. Goal is to develop preventive strategies.
Research Keywords
Cellular and molecular mechanisms of adhesion formation in an in vivo model.
Clinical Research Keywords
chemotherapy, ovarian cancer, endometrial cancer, cervical cancer
Publications
Herington JL, Crispens MA, Carvalho-Macedo AC, Camargos AF, Lebovic DI, Bruner-Tran KL, Osteen KG. Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Fertil. Steril [print-electronic]. 2011 Mar 3/15/2011; 95(4): 1295-301.e1. PMID: 20934690, PMCID: PMC3038191, PII: S0015-0282(10)02547-1, DOI: 10.1016/j.fertnstert.2010.09.017, ISSN: 1556-5653.
Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil. Steril [print-electronic]. 2010 May 5/15/2010; 93(8): 2519-24. PMID: 19608172, PMCID: PMC2873129, PII: S0015-0282(09)01231-X, DOI: 10.1016/j.fertnstert.2009.05.076, ISSN: 1556-5653.
Fleischer AC, Lyshchik A, Jones HW, Crispens MA, Andreotti RF, Williams PK, Fishman DA. Diagnostic parameters to differentiate benign from malignant ovarian masses with contrast-enhanced transvaginal sonography. J Ultrasound Med. 2009 Oct; 28(10): 1273-80. PMID: 19778872, PII: 28/10/1273, ISSN: 1550-9613.
Fleischer AC, Lyshchik A, Jones HW, Crispens M, Loveless M, Andreotti RF, Williams PK, Fishman DA. Contrast-enhanced transvaginal sonography of benign versus malignant ovarian masses: preliminary findings. J Ultrasound Med. 2008 Jul; 27(7): 1011-8; quiz 1019. PMID: 18577664, PII: 27/7/1011, ISSN: 0278-4297.
Bruner-Tran KL, Yeaman GR, Crispens MA, Igarashi TM, Osteen KG. Dioxin may promote inflammation-related development of endometriosis. Fertil. Steril [print-electronic]. 2008 May; 89(5 Suppl): 1287-98. PMID: 18394613, PMCID: PMC2430157, PII: S0015-0282(08)00367-1, DOI: 10.1016/j.fertnstert.2008.02.102, ISSN: 1556-5653.
Rao G, Crispens M, Rothenberg ML. Intraperitoneal chemotherapy for ovarian cancer: overview and perspective. J. Clin. Oncol. 2007 Jul 7/10/2007; 25(20): 2867-72. PMID: 17617517, PII: 25/20/2867, DOI: 10.1200/JCO.2007.10.8167, ISSN: 1527-7755.
Shvartsman HS, Sun CC, Bodurka DC, Mahajan V, Crispens M, Lu KH, Deavers MT, Malpica A, Silva EG, Gershenson DM. Comparison of the clinical behavior of newly diagnosed stages II-IV low-grade serous carcinoma of the ovary with that of serous ovarian tumors of low malignant potential that recur as low-grade serous carcinoma. Gynecol. Oncol [print-electronic]. 2007 Jun; 105(3): 625-9. PMID: 17320156, PII: S0090-8258(07)00055-8, DOI: 10.1016/j.ygyno.2007.01.030, ISSN: 0090-8258.
Fleischer AC, Milam MR, Crispens MA, Shappell HW. Sonographic depiction of intratumoral vascularity with 2- and 3-dimensional color Doppler techniques. J Ultrasound Med. 2005 Apr; 24(4): 533-7. PMID: 15784771, PII: 24/4/533, ISSN: 0278-4297.
Milam MR, Schultenover SJ, Crispens M, Parker L. Retroperitoneal fibrosis secondary to actinomycosis with no intrauterine device. Obstet Gynecol. 2004 Nov; 104(5 Pt 2): 1134-6. PMID: 15516426, PII: 104/5/1134, DOI: 10.1097/01.AOG.0000144118.90772.a1, ISSN: 0029-7844.
Storck K, Crispens M, Brader K. Squamous cell carcinoma of the cervix presenting as lymphangitic carcinomatosis: a case report and review of the literature. Gynecol. Oncol. 2004 Sep; 94(3): 825-8. PMID: 15350381, PII: S0090825804004135, DOI: 10.1016/j.ygyno.2004.06.002, ISSN: 0090-8258.
Crispens MA. Borderline ovarian tumours: a review of the recent literature. Curr. Opin. Obstet. Gynecol. 2003 Feb; 15(1): 39-43. PMID: 12544500, DOI: 10.1097/01.gco.0000051559.77832.b6, ISSN: 1040-872X.
Crispens MA, Bodurka D, Deavers M, Lu K, Silva EG, Gershenson DM. Response and survival in patients with progressive or recurrent serous ovarian tumors of low malignant potential. Obstet Gynecol. 2002 Jan; 99(1): 3-10. PMID: 11777502, PII: S0029784401016490, ISSN: 0029-7844.
Yoneda J, Kuniyasu H, Crispens MA, Price JE, Bucana CD, Fidler IJ. Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J. Natl. Cancer Inst. 1998 Mar 3/18/1998; 90(6): 447-54. PMID: 9521169, ISSN: 0027-8874.
Brader KR, Wolf JK, Hung MC, Yu D, Crispens MA, van Golen KL, Price JE. Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism. Clin. Cancer Res. 1997 Nov; 3(11): 2017-24. PMID: 9815592, ISSN: 1078-0432.
Chapman SJ, Crispens M, Owen J, Savage K. Complications of midtrimester pregnancy termination: the effect of prior cesarean delivery. Am. J. Obstet. Gynecol. 1996 Oct; 175(4 Pt 1): 889-92. PMID: 8885742, PII: S0002937896800196, ISSN: 0002-9378.
Naumann RW, Crispens MA, Alvarez RD, Partridge EE, Shingleton HM, Kilgore LC. Treatment of cervical dysplasia with large loop excision of the transformation zone: is endocervical curettage necessary?. South. Med. J. 1996 Oct; 89(10): 961-5. PMID: 8865787, ISSN: 0038-4348.
Watts RG, Crispens MA, Howard TH. A quantitative study of the role of F-actin in producing neutrophil shape. Cell Motil. Cytoskeleton. 1991; 19(3): 159-68. PMID: 1878986, DOI: 10.1002/cm.970190304, ISSN: 0886-1544.
Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Fertil. Steril [print-electronic]. 2010 May 5/15/2010; 93(8): 2519-24. PMID: 19608172, PMCID: PMC2873129, PII: S0015-0282(09)01231-X, DOI: 10.1016/j.fertnstert.2009.05.076, ISSN: 1556-5653.
Fleischer AC, Lyshchik A, Jones HW, Crispens MA, Andreotti RF, Williams PK, Fishman DA. Diagnostic parameters to differentiate benign from malignant ovarian masses with contrast-enhanced transvaginal sonography. J Ultrasound Med. 2009 Oct; 28(10): 1273-80. PMID: 19778872, PII: 28/10/1273, ISSN: 1550-9613.
Fleischer AC, Lyshchik A, Jones HW, Crispens M, Loveless M, Andreotti RF, Williams PK, Fishman DA. Contrast-enhanced transvaginal sonography of benign versus malignant ovarian masses: preliminary findings. J Ultrasound Med. 2008 Jul; 27(7): 1011-8; quiz 1019. PMID: 18577664, PII: 27/7/1011, ISSN: 0278-4297.
Bruner-Tran KL, Yeaman GR, Crispens MA, Igarashi TM, Osteen KG. Dioxin may promote inflammation-related development of endometriosis. Fertil. Steril [print-electronic]. 2008 May; 89(5 Suppl): 1287-98. PMID: 18394613, PMCID: PMC2430157, PII: S0015-0282(08)00367-1, DOI: 10.1016/j.fertnstert.2008.02.102, ISSN: 1556-5653.
Rao G, Crispens M, Rothenberg ML. Intraperitoneal chemotherapy for ovarian cancer: overview and perspective. J. Clin. Oncol. 2007 Jul 7/10/2007; 25(20): 2867-72. PMID: 17617517, PII: 25/20/2867, DOI: 10.1200/JCO.2007.10.8167, ISSN: 1527-7755.
Shvartsman HS, Sun CC, Bodurka DC, Mahajan V, Crispens M, Lu KH, Deavers MT, Malpica A, Silva EG, Gershenson DM. Comparison of the clinical behavior of newly diagnosed stages II-IV low-grade serous carcinoma of the ovary with that of serous ovarian tumors of low malignant potential that recur as low-grade serous carcinoma. Gynecol. Oncol [print-electronic]. 2007 Jun; 105(3): 625-9. PMID: 17320156, PII: S0090-8258(07)00055-8, DOI: 10.1016/j.ygyno.2007.01.030, ISSN: 0090-8258.
Fleischer AC, Milam MR, Crispens MA, Shappell HW. Sonographic depiction of intratumoral vascularity with 2- and 3-dimensional color Doppler techniques. J Ultrasound Med. 2005 Apr; 24(4): 533-7. PMID: 15784771, PII: 24/4/533, ISSN: 0278-4297.
Milam MR, Schultenover SJ, Crispens M, Parker L. Retroperitoneal fibrosis secondary to actinomycosis with no intrauterine device. Obstet Gynecol. 2004 Nov; 104(5 Pt 2): 1134-6. PMID: 15516426, PII: 104/5/1134, DOI: 10.1097/01.AOG.0000144118.90772.a1, ISSN: 0029-7844.
Storck K, Crispens M, Brader K. Squamous cell carcinoma of the cervix presenting as lymphangitic carcinomatosis: a case report and review of the literature. Gynecol. Oncol. 2004 Sep; 94(3): 825-8. PMID: 15350381, PII: S0090825804004135, DOI: 10.1016/j.ygyno.2004.06.002, ISSN: 0090-8258.
Crispens MA. Borderline ovarian tumours: a review of the recent literature. Curr. Opin. Obstet. Gynecol. 2003 Feb; 15(1): 39-43. PMID: 12544500, DOI: 10.1097/01.gco.0000051559.77832.b6, ISSN: 1040-872X.
Crispens MA, Bodurka D, Deavers M, Lu K, Silva EG, Gershenson DM. Response and survival in patients with progressive or recurrent serous ovarian tumors of low malignant potential. Obstet Gynecol. 2002 Jan; 99(1): 3-10. PMID: 11777502, PII: S0029784401016490, ISSN: 0029-7844.
Yoneda J, Kuniyasu H, Crispens MA, Price JE, Bucana CD, Fidler IJ. Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J. Natl. Cancer Inst. 1998 Mar 3/18/1998; 90(6): 447-54. PMID: 9521169, ISSN: 0027-8874.
Brader KR, Wolf JK, Hung MC, Yu D, Crispens MA, van Golen KL, Price JE. Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism. Clin. Cancer Res. 1997 Nov; 3(11): 2017-24. PMID: 9815592, ISSN: 1078-0432.
Chapman SJ, Crispens M, Owen J, Savage K. Complications of midtrimester pregnancy termination: the effect of prior cesarean delivery. Am. J. Obstet. Gynecol. 1996 Oct; 175(4 Pt 1): 889-92. PMID: 8885742, PII: S0002937896800196, ISSN: 0002-9378.
Naumann RW, Crispens MA, Alvarez RD, Partridge EE, Shingleton HM, Kilgore LC. Treatment of cervical dysplasia with large loop excision of the transformation zone: is endocervical curettage necessary?. South. Med. J. 1996 Oct; 89(10): 961-5. PMID: 8865787, ISSN: 0038-4348.
Watts RG, Crispens MA, Howard TH. A quantitative study of the role of F-actin in producing neutrophil shape. Cell Motil. Cytoskeleton. 1991; 19(3): 159-68. PMID: 1878986, DOI: 10.1002/cm.970190304, ISSN: 0886-1544.